`
`James F. Brennan III
`
`
`617-301-0490 (C)
` 512-634-2952 (O)
`
`Cambridge, MA
`
`Studied cardiovascular pathophysiology.
`
`1250 S Capital of Texas Highway
`Austin, TX 78746
`jbrennan@exponent.com
`
`Education:
`Massachusetts Institute of Technology
`Ph.D. Physics & Electrical Engineering, September 1995. Specialized in biomedical optics.
`Electrical Engineer degree, January 1991. Concentrated in continuum electromechanics.
`S.M. Electrical Engineering, June 1989. Concentrated in electromagnetic field and wave theory.
`S.B. Electrical Engineering and Computer Science, June 1987.
`
`Harvard Medical School, Cambridge, MA
`
`
`Experience:
`
`Menlo Park, CA
`Exponent, Inc
`January 12 – present
`Principal
`Serve as a science and engineering technical consultant for hundreds of companies throughout the world that range
`from pre-revenue organizations to multi-national corporations. Provide guidance on proactive technical challenges
`involving development and compliance issues, as well as reactive concerns, such as regulatory recalls and litigation.
`Have supported, written reports, and given testimony as a technical expert in several litigation and intellectual property
`cases.
`
`Assist various companies with mergers and acquisitions from a technology assessment standpoint. Typical projects
`have involved scouting a given technology space for potential acquisition targets, evaluating the intellectual property,
`and assisting in placing a monetary value on certain key targets. Often alternative product and technology development
`plans are established with costs and timelines, which are used to assist engagement discussions. Have also served as an
`intermediary to form a firewall between separate organizations engaged in technology licensing, and have been utilized
`to assist companies in making products in regulated arenas through activities such as establishing development
`programs, quality systems, and regulatory strategies. Regularly conduct technology scoping exercises by reaching into
`Exponent’s technical expertise to help companies address multi-disciplinary challenges.
`
`Projects included complex medical devices, which often involve hardware, software, optics, and control systems, some
`of which have been implantable or communicate wirelessly. Led projects involving radiation sources in medical
`devices, e.g. x-ray, ultrasound, lasers, and LEDs, for diagnostic, cosmetic, and surgical applications, assisted
`organizations with radiation sources in consumer devices, such as LIDAR, laser machining, and scanning remote
`sensors, and checked for compliance with various regulatory standards. Have also been involved in evaluating
`electrical shock incidents, fire investigations, monopolar and bipolar electrosurgical equipment (RF ablation), wearable
`technology, and smart & IR radiative clothing. Regularly assist companies to ensure product compatibility with MRI,
`electronic article surveillance (EAS) systems, and other possible electromagnetic environments.
`
`Doylestown, PA
`Prescient Medical, Inc
`July 06 – December 11
`Chief Science Officer
`Member of executive team that managed $64M to develop products to prevent heart attacks, primarily by identifying
`and treating atherosclerotic plaques that are prone to rupture. Developed a transcutaneous coronary diagnostic system,
`worked to prioritize the company’s next products, and built a development plan for the product platform. Created and
`maintained awareness and excitement for both the company and its technologies in the scientific & medical community
`and for potential partners through presentations, white papers, and publications. Collaborated in the design, monitoring
`and output of pre-clinical and clinical trials.
`
`Specific accomplishments include the development of an optical catheter system that diagnosed coronary artery disease
`by utilizing Raman spectroscopy to identify and to quantify chemicals within artery walls. Chemical information was
`obtained in real-time to identify thin-capped fibroatheromas (TCFA - vulnerable atherosclerotic plaques) and other
`
`US Conec EX1006
`IPR2024-00115
`U.S. Patent No. 11,307,369
`
`

`

`histopathology in situ. Marketing and product specifications were established by working closely with key opinion
`leaders, and then a development plan was implemented that entailed dividing the project into several major subunits,
`including a console with an optical engine, a fiber optic catheter, and software. The project plan was implemented by
`an extended team of >100 members, which consisted of a combination of internal staff, academic laboratories,
`consultants, and subcontractors, that were located throughout North America and Europe. Identified and acquired
`complementary technologies to the Raman catheter through licensing and technology transfer agreements to bolster
`product acceptance and designed a combination technology product. An IP strategy was established, which included
`protecting several 2nd-generation catheter designs that combined Raman spectroscopy technology with other
`cardiovascular diagnostic modalities, such as optical coherence tomography.
`
`
`Orlando, FL
`Raydiance, Inc
`V.P. of Research and Development
`October 04 – June 06
`Built, led, and managed the entire product development team in a pre-revenue environment to build high-power fiber
`laser systems that addressed the medical and military laser micromachining markets, reporting directly to the CEO and
`COO.
`
`Accomplishments played a large role in increasing the company valuation from $40M at Round B to $90M at Round C.
`Hired by investors at Round B financing to realize the company vision, i.e. to build compact ultrashort pulse lasers at
`ablation-level energies with flexible user interfaces that are ready for OEM incorporation. Assessed initial company
`technology, built technical capabilities and technical team, created and implemented a product roadmap, and
`established scalable business practices. Steered company away from flawed initial technical paths towards an approach
`involving optical fiber amplifier systems and implemented this new approach by hiring specialist to train and work with
`the internal team. Acquired expertise in high-power chirped-pulse fiber amplifier systems, solid-state optical
`amplifiers, and specialized fiber delivery systems. Was the technical lead for existing government programs and
`crafted new government proposals where the work mapped directly onto the company technical roadmap. Identified
`Bragg fiber technology as a potentially disruptive technology, implemented IP strategy to protect technology, and
`obtained funding for feasibility work at a university and for internalizing the technology. Established requirements
`needed to address certain markets for ultrashort pulse laser requirements for non-thermal ablation and thus drove
`guidelines for initial product and subsequent releases, and steered product development to completion, resulting in
`several recognitions and awards for the product and corporation, including the “Red Herring 100 North America”
`award and a finalist in the “Most Innovative Company” category in the 2008 American Business Awards.
`
`Developed and implemented an IP strategy by working closely with a prominent San Jose legal firm that specializes in
`startup companies. Evaluated and organized prior patent filings, implemented a record-of-invention filing and
`evaluation process, trained a new patent liaison, educated technical team on IP and the patenting process, and aided the
`transition of the patent portfolio to a new legal firm. 50+ inventions filed internally by technical team in year 2005,
`which were triaged and converted to ~2 patents applications filed per month.
`
`
`Austin, TX
`3M Company
`Sr. Research Specialist
`August 96 – September 04
`Built and established a laboratory to develop passive optical components that addressed the telecommunications and
`sensor industries, which became the cornerstone of the Optical Components business unit.
`
`Began in a staff laboratory and studied several issues related to fiber Bragg grating fabrication to improve their quality
`and to increase production yields, such as hydrogen diffusion in silica, fiber fixturing, fiber photosensitivity,
`ultraviolet-induced optical loss, and optical and mechanical lifetime issues. Invented a direct-write technology for
`producing fiber gratings of arbitrary reflectivity profiles and lengths and utilized the method to make chromatic
`dispersion compensators for use in long-haul communications systems. Devised and executed an intellectual property
`strategy for protecting the technology, which became a platform technology, including process, device, and application
`patent filings. Brought the technology into a business unit and developed products around it. Led technical team of
`>50 scientist and engineers on a multimillion dollar development effort to bring product into manufacturing and
`through Telcordia testing. Interacted with hundreds of customers throughout N. America, Europe, and SE Asia (Japan,
`China, & Singapore) to discern their needs and directed internal laboratory efforts to address technical gaps. One
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`product won the 2002 Photonics Circle of Excellence award from Photonics Spectra for one of the 25 most technically
`innovative products of the year and was also nominated by Fiberoptic Product News for the 2001 technology award.
`
`Specific technical accomplishments include designing and building systems to make multimeter length fiber gratings,
`which involved custom low rotational-velocity rotary induction motors and control systems, ultra-precision machined
`components (10 microinch), exacting air-bearing translation stages and controls, interferometers, and software control.
`Construction of these manufacturing systems spawned several other inventions, such as function generators capable of
`an unlimited number of <10 Hz steps, fabrication methods of co-propagating mode fiber couplers, and fiber handling
`devices. Other technical accomplishments included building hydrogenation system capable of 30,000 p.s.i. pressures,
`understanding the optical properties of fibers exposed to extreme environments, and establishing a 10 Gbit/s optical
`telecommunication test system.
`
`Principal investigator on a DARPA subcontract that employed chirped pulse amplification and semiconductor optical
`amplifiers to produce high-peak-power femtosecond-duration light pulses for laser micromachining and concurrently
`led efforts within 3M to make products utilizing this technology, including market and IP assessment. Other general
`responsibilities included identifying and evaluating new technology, serving as a laser safety officer, assessing the
`capabilities of potential acquisitions, and acting as a university liaison and initiating collaborations.
`
`Leiden, The Netherlands
`Academisch Ziekenhuis
`Rotterdam, The Netherlands
`Erasmus Universiteit
`Independent consultant
`March 96 – August 96
`Provided technical consulting for development of Raman spectroscopy systems for human tissue studies. Conceived
`and started a research plan for Leiden University that led to several articles and a Ph.D. thesis for one student.
`
`Cambridge, MA
`G. R. Harrison Spectroscopy Laboratory, M.I.T.
`August 95 – March 96
`Postdoctoral scientist
`Research assistant
`January 91 – August 95
`Conceived and developed signal processing algorithms to extract quantitative biochemical information about human
`tissue with near infrared Raman spectroscopy. Invented an optical fiber probe that uses a compound parabolic
`concentrator to increase significantly light collection. Designed and built electro-optical instrumentation for Raman
`and laser-induced fluorescence spectroscopy, including photodiode arrays, CCD systems and PdSi focal plane arrays.
`Used Raman scattering and laser-induced fluorescence to diagnose various pathologies, including various cancers and
`atherosclerosis. Conducted research independently and gained general experience with optics, nonimaging optics, laser
`systems, turbid media, probabilistic systems, light-matter interactions, and biomedical engineering.
`
`Cambridge, MA
`M.I.T. Continuum Electromechanics Laboratory
`Teaching assistant
`September 90 - December 90
`Research assistant
`January 90 - September 90
`Investigated momentum transfer mechanisms in electro-rheological fluids. Conceived, designed, and implemented
`unique couette viscometer to simultaneously measure normal and tangential stresses within ER fluids.
`
`Head teaching assistant
`September 89 - December 89
`Assisted Prof. Hermann A. Haus in teaching class entitled “Electromagnetic Fields and Energy”. Managed teaching
`assistants and conducted interactive mini-lectures weekly. Acted as substitute lecturer.
`
`Lexington, MA
`Lincoln Laboratory
`Radar analyst
`May 89 - September 89
`Proposed and implemented various methods for determining material makeup of exo-atmospheric objects through
`analysis of microwave radar returns.
`
`Cambridge, MA
`M.I.T. High Voltage Research Laboratory
`Research assistant
`May 87 - May89
`Discovered unusual optical phenomena associated with molten polymers. Investigated charge migration in
`polyethylene under high voltage stressed situations by utilizing Kerr elecro-optical measurement techniques.
`
`Undergraduate Research Assistant
`
`May 86 - May 87
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`Cambridge , MA
`May 85 - August 85
`
`Cambridge, MA
`December 84 - February 85
`
`Automated Kerr electro-optical field mapping measurements with an image digitizer installed in an IBM PC.
`Contributed to the understanding of electric charge movement in polymethylmethacrylate.
`
`Lexicon, Inc.
`Junior engineer
`
`Softbridge Microsystems, Inc.
`Software engineer
`
`Professional:
`Have held memberships in various professional organizations, such as OSA, SPIE, & IEEE. Committee member for
`OSA’s 2007 conference on Optical Fiber Communications. Committee member for OSA’s Bragg Gratings,
`Photosensitivity, and Poling topical conference for 1999, 2001, & 2003. Regular reviewer for IEEE Photonics
`Technology Letters, as well as several other journals. Research work highlighted in various trade journals, such as The
`Economist (10 August 1996, p. 64), Analytical Chemistry News and Features (1 June 1997, pp. 336-7 A), FiberSystems
`International (Apr/May 2000, p. 15), Lightwave (July 2000, p.140-1), Laser Focus World (April 2000, p. 109),
`Photonics Spectra (May 2001, p. 34), Photonics Spectra (January 2003, p. 83) and Photonics Spectra (March 2003,
`p.100). Invited speaker to several universities, such as M.I.T., U of Texas at Austin, Texas A & M, and University of
`Rochester, NY.
`
`Member of ANSI Z136.3 Standard Subcommittee (SSC-3), “Safe Use of Lasers in Health Care.”
`
`Member of ANSI Z136.9 Standard Subcommittee (SSC-9), “Safe Use of Lasers in Manufacturing Environments.”
`
`Member of ANSI Z136 Technical Subcommittee 1 (TSC1), “Biological Effects and Medical Surveillance.”
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`Patents:
`
`US #8,189,971 - Vaissié L & Brennan JF, “Dispersion Compensation in a chirped pulse amplification system,” May
`29, 2012.
`
`US #8,150,271 – Brennan JF, Vaissié L, & Mielke M, “Active tuning of temporal dispersion in an ultrashort pulse laser
`system,” April 3, 2012.
`
`US #7,952,719 – Brennan JF, “Optical catheter configurations combining Raman spectroscopy with optical fiber-based
`low coherence reflectometry,” May 31, 2011.
`
`US #7,952,706 – Ling J, Mitchell JN, Sullivan ME, Brennan JF, Heistand MR, Nazemi J, & Fraker W, “Multi-channel
`fiber optic spectroscopy systems employing integrated optics modules,” May 31, 2011.
`
`US #7,835,646 – Vaissié L & Brennan JF, “High-order Bragg fiber dispersion correction,” November 16, 2010.
`
`US #7,822,347 – Brennan JF, Vaissié L, & Mielke M, “Active tuning of temporal dispersion in an ultrashort pulse laser
`system,” October 26, 2010.
`
`US #7,787,175 – Brennan JF, Vaissié L, Mielke M, & Yilmaz T “Pulse selecting in a chirped pulse amplification
`system,” August 31, 2010.
`
`US #7,593,441 – Brennan JF, Vaissié L, & Mielke M, “Bragg fibers in systems for the generation of high peak power
`light,” September 22, 2009.
`
`US #7,496,255 – Cronk BJ, MacDougall TW, David MM, Gates BJ, & Brennan JF, “Radiation-transmissive films on
`glass articles,” February 24, 2009.
`
`US #7,466,892 – LaBrake DL, Gates BJ, Cronk BJ, David MM, Nelson BK, Miller MN, & Brennan JF, “Optical and
`optoelectronic articles,” December 16, 2008.
`
`US #7,436,866 – Vaissié L & Brennan JF, “Combination optical isolator and pulse compressor,” October 14, 2008.
`
`US #7,433,558 – Booth TJ, Yilmaz IT, Brennan JF, “Methods for optical isolation in high power fiber-optic systems,”
`October 7, 2008.
`
`US #7,349,452 – Brennan JF, Vaissié L, Mielke M, “Bragg fibers in systems for the generation of high peak power
`light,” March 25, 2008.
`
`US #7,308,171 – Booth TJ, Yilmaz IT, & Brennan JF, “Method and apparatus for optical isolation in high power fiber-
`optic systems,” December 11, 2007.
`
`US #7,245,419 – Brennan JF & Booth TJ, “Wavelength-stabilized pump diodes for pumping gain media in an
`ultrashort pulsed laser system,” July 17, 2007.
`
`US # 7,139,116 – Vaissié L & Brennan JF, “Post amplification optical isolator,” November 21, 2006.
`
`US # 7,106,939 – LaBrake DL, Gates BJ, Cronk BJ, David MM, Nelson BK, Miller MN, & Brennan JF, “Optical and
`optoelectronic articles,” September 12, 2006.
`
`US # 6,901,188 – Brennan JF, “Dispersion compensation modules with fiber Bragg gratings,” May 31, 2005.
`
`US # 6,857,293 – Carpenter JB, Stedman JP, Bylander JR, Wiegand G, Stacey NA, Gatica AW, Elder DE, & Brennan
`JF, “Apparatus for selective photosensitization of optical fiber,” February 22, 2005.
`
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`US # 6,834,134 – Brennan JF, Chou PC, Lee HLT, Ram RJ, Haus HA, Ippen EP, “Method and apparatus for
`generating frequency modulated pulses,” December 21, 2004.
`
`US # 6,823,110 – Battiato JM & Brennan JF, “Method to stabilize and adjust the optical path length of waveguide
`devices,” November 23, 2004.
`
`US # 6,795,636 – Cronk BJ, MacDougall TW, David MM, Gates BJ, Nelson BK, & Brennan JF, “Radiation-
`transmissive films on glass articles,” September 21, 2004.
`
`US # 6,781,698 – Fan X, Brennan JF, Matthews MR, Sinha PG, & Porque JC, “Quality review method for optical
`components using a fast system performance characterization,” August 24, 2004.
`
`US # 6,763,686 – Carpenter J, Stedman J, Bylander J, Wiegand G, Stacy N, Gatica T, Elder D, Brennan JF, & Cronk B,
`“Method for selective photosensitization of optical fiber,” July 20, 2004.
`
`US # 6,741,773 – Brennan JF, Hernandez E, Valenti J, Sinha P, Matthews M, Elder D, Beauchesne G, & Byrd C,
`“Wide- bandwidth chirped fiber Bragg gratings with low delay ripple amplitude,” May 25, 2004.
`
`US # 6,728,444 – Brennan JF & LaBrake DL, “Fabrication of chirped fiber Bragg gratings of any desired bandwidth
`using frequency modulation,” April 27, 2004.
`
`US # 6,668,126 – Brennan JF & Knox GJ, “Temperature stabilized optical fiber package.” December 23, 2003.
`
`US # 6,577,792 – Brennan JF, Hernandez E, Valenti J, Sinha P, Matthews M, Elder D, Beauchesne G, & Byrd C,
`“Wide- bandwidth chirped fiber Bragg gratings with low delay ripple amplitude,” June 10, 2003.
`
`US # 6,404,956 – Brennan JF & LaBrake DL, “Long-length continuous phase Bragg reflectors in optical media,” June
`11, 2002.
`
`US # 6,311,524 – Brennan JF, Sloan DA, Fahey MT, & Novack JC, “Accelerated method for increasing the
`photosensitivity of a glassy material,” November 6, 2001.
`
`US # 6,195,484 – Brennan JF, LaBrake DL, Chou PC, Haus HA, “Method and apparatus for arbitrary spectral shaping
`of an optical pulse,” February 27, 2001.
`
`US # 6,035,083 – Brennan JF & LaBrake DL, “Method for writing arbitrary index perturbations in a waveguiding
`structure,” March 7, 2000.
`
`US # 5,912,999 – Brennan JF, LaBrake DL, Beauchesne GA, & Pepin RP, “Method for fabrication of in-line optical
`waveguide index grating of any length”, June 15, 1999.
`
`US # 5,615,673 - Berger A, Brennan JF, Dasari RR, Feld MS, Itzkan I, Tanaka K, and Wang Y, “Apparatus and
`methods of Raman spectroscopy for analysis of blood gases and analytes”, April 1, 1997.
`
`Several additional patents filed and pending.
`
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`Book Chapters:
`
`Nazemi JH, Marple E, Sangiorgi G, and Brennan JF, “Evaluation of plaque composition with intracoronary Raman
`spectroscopy,” in Coronary Artery Stenosis – Imaging, structure and physiology, eds. Escaned J and Serruys PW, (PCR
`Publishing) ISBN: 978-2-913628-56-4 (2010), Chapter 19, pp. 263-272.
`
`Brennan JF, “Broadband fiber Bragg gratings for dispersion management,” Chapt. 9 in Fiber-based dispersion
`compensation, ed. S Ramachandran (Springer Verlag) ISBN: 978-0-387-40347-2 (2007).
`
`Römer TJ, Brennan JF, and Buschman HPJ, “Raman spectroscopy of atherosclerosis: towards real-time in vivo
`histochemistry and pathology,” Chapt. 3 in Advanced Imaging in Coronary Artery Disease – PET, SPECT, MRI, IVUS,
`EBCT, eds. Van der Wall EE, Blanksma PK, Niemeyer MG, Vaalburg W, and Crijns HJGM (Kluwer Academic
`Publishers, Dordrecht, 1998), pp. 29-53, ISBN 0-7923-5083-9.
`
`Römer TJ, Brennan JF, Tuinenburg J, van Duinen SG, van der Laarse A, Bruschke AVG, and Puppels GJ, in
`Spectroscopy of Biological Molecules: Modern Trends, eds. Carmona P, et al. HJGM (Kluwer Academic Publishers,
`Dordrecht, 1997).
`
`Römer TJ and Brennan JF, “Raman-spectroscopy during catheterization: a means of viewing plaque composition,”
`Chapt. 11 in Vascular Medicine – from Endothelium to Myocardium, eds. Van der Wall EE, Cats VM & Baan J
`(Kluwer Academic Publishers, Dordrecht, 1997), pp. 175-196, ISBN 0-7923-4740-4.
`
`
`Journal articles:
`
`Anderson DM, Fessler JR, Pooley MA, Seidel S, Hamblin MR, Beckham HW, & Brennan JF, “Infrared radiative
`properties and thermal modeling of ceramic-embedded textile fabrics,” Biomedical Optics Express, in press.
`
`Pooley MA, Anderson DM, Beckham HW, & Brennan JF, “Engineered emissivity of textile fabrics by the inclusion of
`ceramic particles,” Optics Express, 24(10), 5 May 2016, pp. 10556-10564.
`
`Nazemi JH & Brennan JF, “Lipid concentrations in human coronary artery determined with high wavenumber Raman
`shifted light,” Virtual Journal of Biological Physics Research, May 15, 2009.
`
`Nazemi JH & Brennan JF, “Lipid concentrations in human coronary artery determined with high wavenumber Raman
`shifted light,” Journal of Biomedical Optics, Vol. 14(3), May/June 2009, 034009.
`
`Brennan JF, Nazemi J, Motz J, & Ramcharitar S, “The vPredict Optical Catheter System: Intravascular Raman
`spectroscopy,” Eurointervention, 2008; 3:635-638.
`
`Brennan JF, “Broadband fiber Bragg gratings for dispersion management,” Journal of Optical Fiber Commun. Rep., 2
`(5), 397-434 (December 2005) DOI: 10.1007/s10297-005-0055-z.
`
`Wang D, Matthews M, & Brennan JF, “Polarization mode dispersion in chirped fiber Bragg gratings”, Optics Express,
`12 (23), 15 November 2004, pp. 5741-5753.
`
`Fan X & Brennan JF, “Performance effect in optical-communication systems caused by phase ripples of dispersive
`components,” Applied Optics, 43 (26), pp. 5033-5036 (September 2004).
`
`Brennan JF, Bungarden PM, Fisher CE, & Jennings RM, “Packaging to reduce thermal gradients along the length of
`long fiber gratings,” Photonics Technology Letters, 16 (1), January 2004, 156-8.
`
`Brennan JF, Matthews MR, Dower WV, Treadwell DJ, Wang W, Porque J, & Fan X, “Dispersion correction with a
`robust fiber grating over the full C-band at 10 Gb/s rates with <0.3 dB power penalties,” Photonics Technology Letters,
`15 (12), December 2003, pp. 1722-1724.
`
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`Koch BJ & Brennan JF, “Dispersion compensation in an optical communications system with an electro-absorption
`modulated laser and a fiber grating,” Photonics Technology Letters, 15 (11), November 2003, pp. 1633-1635.
`
`Chou PC, Haus HA, & Brennan JF, “Reconfigurable time-domain spectral shaping of an optical pulse stretched by a
`fiber Bragg grating,” Optics Letters 25 (8) (15 April 2000), pp. 524-6.
`
`Brennan JF, Sloan DA & LaBrake DL, “The behavior of silica optical fibers exposed to very high-pressure hydrogen
`environments,” OSA Trends in Optics and Photonics series, “WDM components”, ed. DA Nolan, XXIX, pp. 286-91.
`
`Römer TJ, Brennan JF, Puppels GJ, Zwinderman AH, van Duinen SG, van der Laarse A, van der Steen AFW, Bom
`NA, , & Bruschke AVG, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify
`cholesterol and calcium salts in atherosclerotic coronary arteries”, Atheriosclerosis, Thrombosis and Vascular Biology
`(2000), 20, pp.478-483.
`
`Römer TJ, Brennan JF, Puppels GJ, van der Laarse A, Princen H, Buschman R, Jukema JW, Havekes LM & Bruschke
`AVG, “Raman spectroscopy provides chemical mappings of athersoclerotic plaques in APOE*3 Leiden transgenic
`mice”, submitted.
`
`Römer TJ, Brennan JF, Bakker-Schut TC, Wolthuis R, van den Hoogen RCM, Jemeis JJ, van der Laarse A, Bruschke
`AVG, & Puppels G, “Raman spectroscopy for quantifying cholesterol in intact coronary artery wall,” Atherosclerosis
`(November 1998), 141 (1), pp. 117-124.
`
`Salenius JP, Brennan JF, Miller A, Wang Y, Aretz T, Sacks B, Dasari RR & Feld MS, “Biochemical composition of
`human peripheral arteries examined with near infrared Raman spectroscopy”, J. Vascular Surgery, (April 1998), 27 (4),
`pp. 710-19.
`
`Römer TJ, Brennan JF, Fitzmaurice M, Feldstein ML, Deinum G, Myles JL, Kramer JR, Lees RS & Feld MS,
`“Histopathology of human coronary artery atherosclerosis by quantifying its chemical composition with Raman
`spectroscopy”, Circulation, 97 (9) (March 1998), pp. 878-885.
`
`Brennan JF, Römer TJ, Lees RS, Tercyak AM, Kramer JR & Feld MS, “Determination of human coronary artery
`composition by Raman spectroscopy”, Circulation, 96 (1) (1997), pp. 99-105.
`
`Brennan JF, Wang Y, Dasari RR & Feld MS, “Near infrared Raman spectrometer systems for human tissue studies”,
`Appl. Spectros., 51 (2) (1997), pp. 201-08.
`
`Brennan JF, Beattie ME, Wang Y, Cantella MJ, Tsaur BY, Dasari RR & Feld MS, “PdSi focal plane array detectors for
`short-wave infrared Raman spectroscopy of biological tissue: a feasibility study”, Appl. Optics, 35 (28), 1 Oct. 1996,
`pp. 5736-5739.
`
`Tanaka K, Pacheco MTT, Brennan JF, Itzkan I, Berger AJ, Dasari RR & Feld MS, “Compound parabolic concentrator
`probe for efficient light collection in spectroscopy of biological tissue”, Appl. Optics, 35 (4), 1 February 1996, pp. 758-
`763.
`
`Cothren RM, Sivak MV, van Dam J, Petras RE, Fitzmaurice M, Crawford JM, Wu J, Brennan JF, Rava RP, Manoharan
`R, & Feld MS, “Detection of dysplasia at colonoscopy using laser-induced fluorescence: a blinded study”,
`Gastrointestinal Endoscopy, 44 (2), August 1996, pp. 168-176.
`
`Brennan JF, Zonios GI, Wang TD, Rava RR, Hayes GB, Dasari RR & Feld MS. “Portable laser spectrofluorimeter for
`in vivo human tissue fluorescence studies”, Appl. Spectros., 47 (12), (1993), pp. 2081-2086.
`
`Hikita, Zahn, Wright, Cooke, & Brennan, “Kerr Electro-optic Field Mapping Measurements in Electron-beam
`Irradiated Polymethylmethacrylate”, IEEE Elect. Insul., 23 (5), (1988) p. 861-880.
`
`Zahn, Hikita, Wright, Cooke, & Brennan, “Kerr Electro-optic Field Mapping Measurements in Electron-beam
`Irradiated Polymethylmethacrylate”, IEEE Elect. Insul., 22 (2), (1987) p.181-185.
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`Conferences:
`
`Fei E, Piper J, Lau E, & Brennan JF, “Optical hazards posed by high-intensity LED flashlights,” International Laser
`Safety Conference, Atlanta, GA (2017), in press.
`
`Nazemi J, Marple E, Brennan JF, Sangiorgi G, and Mauriello A, "Contour mappings of the chemical composition
`within human coronary artery measured with an intravascular Raman spectroscopy system," in SPIE symposium on
`Biomedical Optics (BiOS) 2010, San Fransisco, CA (2010), Paper #7548D-104.
`
`Nazemi J, Brennan JF, Sangiorgi G, and Mauriello A, "Chemical Maps of Human Coronary Artery Measured with a
`Raman Spectroscopy Catheter System Designed for Percutaneous Clinical Use," in Transcatheter Cardiovascular
`Theraputics 2009, San Francisco, CA (2009) Paper #09-A-1416-CRF.
`
`Brennan JF (invited), “Raman Spectroscopy,” 7th International Vulnerable Plaque Meeting, Vouliagmeni, Greece, 21-
`23 June 2009.
`
`Nazemi J, Brennan JF, Sangiorgi G, Mauriello A, and Kutys R, "A label-free optical biosensor for in vivo disease
`classification of coronary artery wall," in CRT 2009 (Cardiovascular Research Technologies), Washington, DC (2009).
`
`Nazemi J and Brennan JF, "A Robust Chemometric Model for Determining the Chemical Composition of Human
`Coronary Artery with Raman Spectroscopy," in Fall Meeting of the Materials Research Society, Symposium AA:
`Materials for Optical Sensors in Biomedical Applications, Boston, MA (2008), Paper #517487.
`
`Nazemi J & Brennan JF, “Discrimination between cholesterol and cholesterol esters in coronary artery tissue with
`Raman spectroscopy,” Transcatheter Cardiovascular Therapeutics 2008, Washington, D.C., 12-17 October 2008, Paper
`TCT-640.
`
`Brennan JF (invited), “Raman Spectroscopy,” 6th International Vulnerable Plaque Meeting, Vouliagmeni, Greece, 22-
`24 June 2008.
`
`Nazemi J and Brennan JF, "Rapid Lipid Identification and Quantification in Coronary Artery Tissue via an Optical
`Fiber Probe with Raman Spectroscopy," in Cardiovascular Revascularization Therapies, Washington, DC (2008), Paper
`#08-A-186-CRT.
`
`Nazemi J & Brennan JF, “Biochemical assay of human artery tissue via a single optical fiber with high waveneumber
`Raman shifted light,” SPIE symposium on Biomedical Optics (BiOS) 2008, San Jose, CA, 19-24 January 2008, Paper
`6842D-80.
`
`Motz JT, Nazemi J, Waxman S, Houser SL, Gardecki JA, Chau AH, Bouma BE, Brennan JF, & Tearney GJ,
`“Intracoronary Raman diagnostics in a human-to-porcine xenograft model,” Transcatheter Cardiovascular Therapeutics
`2007, Washington, D.C., 20-25 October 2007, Paper TCT-334.
`
`Brennan JF (invited), “Intravascular spectroscopy,” 4th Symposium on the Burden of Atherothrombotic Disease:
`Diagnosis and Therapy, New York, NY, 9-10 June 2007.
`
`Motz JT, Puppels GJ, Waxman S, Bakker Schut TC, Marple E, Green N, Nazemi J, Chau AH, Gardecki JA, Brennan
`III JF, and Tearney GJ. Percutaneous Intracoronary Raman Spectroscopy. Cardiovascular Revascularization
`Therapies, Washington, D.C., Paper 813, 7-9 March 2007.
`
`Vaissié L, Kim K, Brennan JF, Mielke MM, Stadler A, Yilmaz T, Saunders T, Goldman D, and Cumbo MJ,
`“Autonomous, flexible and reliable ultra-short pulse laser at 1552.5 nm,” SPIE Photonics West (2007).
`
`Brennan JF (presider), “Grating Properies III”, OSA, Bragg Gratings, Photosensitivity, and Poling ’03 (September
`2003), Monterey, CA, TuD.
`
`
`JF Brennan III
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`4/4/2019
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`Page 9 of 12
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`Fan X, LaBrake, & Brennan JF, “Chirped fiber grating characterization with phase ripples,” OSA, Optical Fiber
`Communication 2003 (March 2003), Atlanta, GA, FC2, pp 638-40
`
`Brennan JF, (invited) “Dispersion management with long-length fiber Bragg gratings,” OSA, Optical Fiber
`Communication 2003 (March 2003), Atlanta, GA, FC1, pp 637-8.
`
`Wang D, Matthews M, & Brennan JF, “PMD measurement of dispersion compensation gratings and its effect on
`system penalty estimation,” OSA, Optical Fiber Communication 2003 (March 2003), Atlanta, GA, WC3, pp 313-4.
`
`Viswanathan NK & Brennan JF, “Indication of re-circulating catalyst in photosensitive reactions with H2-saturated
`silica fibers,” OSA, Optical Fiber Communication 2002 (March 2002), Anaheim, CA, TuQ1, pp. 107-8.
`
`Brennan JF, Matthews MR, and Sinha PG, “The modulation transfer- function of chirped fiber Bragg gratings,” OSA,
`Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides (July 2001), Stressa, Italy, BThC21.
`
`Brennan JF, Hernandez E, Valenti JA, Sinha PG, Matthews MR, Elder DE, Beauchesne GA, & Byrd CH, “Dispersion
`and dispersion-slope correction with a fiber Bragg grating over the full C-band,” OSA, Optical Fiber Communication
`2001 (March 2001), Anaheim, CA, PD12.
`
`David MM, Brennan JF, Cronk B, Gates B, Nelson B, Jorgenson C, LaBrake DL, Paolucci D, Byrd C & Valenti J,
`“Diamond-like film encapsulated fibers for long-length fiber grating production,” IEEE-LEOS Workshop on Fibres and
`Optical Passive Compo