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`Journal of Medicinal Chemistry | Vol 47, No 17
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`August 12, 2004
`Volume 47, Issue 17
`Pages 4111-4338
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`Ribbon rendered illustration of the nuclear receptor heterodimer RXRα(cyan):PPARRγ (red) ligand binding domains
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`In this issue:
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`Miniperspectives:Advances in Type 2 Diabetes
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`MINIPERSPECTIVES:ADVANCES IN TYPE 2 DIABETES
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`Novel “Second-Generation” Approaches for the Control of Type 2 Diabetes
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`David P. Rotella
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`Journal of Medicinal Chemistry 2004, 47, 17, 4111-4112 (Perspective)
`Publication Date (Web): July 20, 2004
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Diabetes Mellitus: Pathogenesis and Treatment Strategies
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`Jay S. Skyler
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`Journal of Medicinal Chemistry 2004, 47, 17, 4113-4117 (Perspective)
`Publication Date (Web): July 20, 2004
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`Journal of Medicinal Chemistry | Vol 47, No 17
`Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists for the
`Treatment of Type 2 Diabetes
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`
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`Brad R. Henke
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`Journal of Medicinal Chemistry 2004, 47, 17, 4118-4127 (Perspective)
`Publication Date (Web): July 20, 2004
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`Glucagon-like Peptide-1: The Basis of a New Class of Treatment for Type 2
`Diabetes
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`Lotte Bjerre Knudsen
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`Journal of Medicinal Chemistry 2004, 47, 17, 4128-4134 (Perspective)
`Publication Date (Web): July 20, 2004
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`Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes
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`3/13/23, 9:13 AM
`Ann E. Weber
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Journal of Medicinal Chemistry 2004, 47, 17, 4135-4141 (Perspective)
`Publication Date (Web): July 20, 2004
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`Prospects for Inhibitors of Protein Tyrosine Phosphatase 1B as Antidiabetic
`Drugs
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`Rob Hooft van Huijsduijnen, Wolfgang H. B. Sauer, Agnes Bombrun, and Dominique Swinnen
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`Journal of Medicinal Chemistry 2004, 47, 17, 4142-4146 (Perspective)
`Publication Date (Web): July 20, 2004
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`LETTERS
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`
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`Structure-Based Design, Synthesis, and Evaluation of Conformationally
`Constrained Mimetics of the Second Mitochondria-Derived Activator of
`Caspase That Target the X-Linked Inhibitor of Apoptosis Protein/Caspase-9
`Interaction Site
`
`Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu, York Tomita, Krzysztof Krajewski, Peter P. Roller
`, and Shaomeng Wang
`
`Journal of Medicinal Chemistry 2004, 47, 17, 4147-4150 (Letter)
`Publication Date (Web): July 16, 2004
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` Abstract
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`Rational Approaches to Discovery of Orally Active and Brain-Penetrable
`Quinazolinone Inhibitors of Poly(ADP-ribose)polymerase
`
`Kouji Hattori, Yoshiyuki Kido, Hirofumi Yamamoto, Junya Ishida, Kazunori Kamijo, Kenji Murano, Mitsuru Ohkubo,
`Takayoshi Kinoshita, Akinori Iwashita, Kayoko Mihara, Syunji Yamazaki, Nobuya Matsuoka, Yoshinori Teramura
`, and Hiroshi Miyake
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`Journal of Medicinal Chemistry 2004, 47, 17, 4151-4154 (Letter)
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`Journal of Medicinal Chemistry | Vol 47, No 17
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` Abstract
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`1
`Dopamine/Serotonin Receptor Ligands. 9. Oxygen-Containing Midsized
`Heterocyclic Ring Systems and Nonrigidized Analogues. A Step toward
`Dopamine D Receptor Selectivity
`5
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`Thomas W. Wittig, Michael Decker, and Jochen Lehmann
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`Journal of Medicinal Chemistry 2004, 47, 17, 4155-4158 (Letter)
`Publication Date (Web): July 16, 2004
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Bulky Nonproteinogenic Amino Acids Permit the Design of Very Small and
`Effective Cationic Antibacterial Peptides
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`Bengt Erik Haug, Wenche Stensen, Trine Stiberg, and John S. Svendsen
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`Journal of Medicinal Chemistry 2004, 47, 17, 4159-4162 (Letter)
`Publication Date (Web): July 16, 2004
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` Abstract
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`A Nonpeptidic Sulfonamide Inhibits the p53−mdm2 Interaction and Activates
`p53-Dependent Transcription in mdm2-Overexpressing Cells
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`Peter S. Galatin and Donald J. Abraham
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`Journal of Medicinal Chemistry 2004, 47, 17, 4163-4165 (Letter)
`Publication Date (Web): July 21, 2004
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`ARTICLES
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Human Integrin αvβ5: Homology Modeling and Ligand Binding
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`Luciana Marinelli, Kay-E. Gottschalk, Axel Meyer, Ettore Novellino, and Horst Kessler
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`Journal of Medicinal Chemistry 2004, 47, 17, 4166-4177 (Article)
`Publication Date (Web): July 10, 2004
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Combining Pharmacophore Search, Automated Docking, and Molecular
`Dynamics Simulations as a Novel Strategy for Flexible Docking. Proof of
`Concept: Docking of Arginine−Glycine−Aspartic Acid-like Compounds into the
`α β Binding Site
`v 3
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`Nicolas Moitessier, Christophe Henry, Bernard Maigret, and Yves Chapleur
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`Journal of Medicinal Chemistry 2004, 47, 17, 4178-4187 (Article)
`Publication Date (Web): July 20, 2004
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`Validation of Automated Docking Programs for Docking and Database
`Screening against RNA Drug Targets
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Journal of Medicinal Chemistry 2004, 47, 17, 4188-4201 (Article)
`Publication Date (Web): July 13, 2004
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`Tricyclic Alkylamides as Melatonin Receptor Ligands with Antagonist or Inverse
`Agonist Activity
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`Valeria Lucini, Marilou Pannacci, Francesco Scaglione, Franco Fraschini, Sivia Rivara, Marco Mor, Fabrizio Bordi,
`Pier Vincenzo Plazzi, Gilberto Spadoni, Annalida Bedini, Giovanni Piersanti, Giuseppe Diamantini, and Giorgio
`Tarzia
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`Journal of Medicinal Chemistry 2004, 47, 17, 4202-4212 (Article)
`Publication Date (Web): July 17, 2004
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2
`Diabetes
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`Thomas W. von Geldern, Noah Tu, Philip R. Kym, James T. Link, Hwan-Soo Jae, Chunqiu Lai, Theresa Apelqvist,
`Patrik Rhonnstad, Lars Hagberg, Konrad Koehler, Marlena Grynfarb, Annika Goos-Nilsson, Johnny Sandberg, Marie
`Österlund, Tomas Barkhem, Marie Höglund, Jiahong Wang, Steven Fung, Denise Wilcox, Phong Nguyen, Clarissa
`Jakob, Charles Hutchins, Mathias Färnegårdh, Björn Kauppi, Lars Öhman, and Peer B. Jacobson
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`Journal of Medicinal Chemistry 2004, 47, 17, 4213-4230 (Article)
`Publication Date (Web): July 13, 2004
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`Solution Structure of Amyloid β-Peptide (25−35) in Different Media
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`Anna M. D'Ursi, Maria R. Armenante, Remo Guerrini, Severo Salvadori, Giuseppe Sorrentino, and Delia Picone
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`Journal of Medicinal Chemistry 2004, 47, 17, 4231-4238 (Article)
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Design, Synthesis, and Biological Evaluation of New Cyclic Disul de
`Decapeptides That Inhibit the Binding of AP-1 to DNA
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`Keiichi Tsuchida, Hisaaki Chaki, Tadakazu Takakura, Junichi Yokotani, Yukihiko Aikawa, Shunichi Shiozawa, Hiroaki
`Gouda, and Shuichi Hirono
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`Journal of Medicinal Chemistry 2004, 47, 17, 4239-4246 (Article)
`Publication Date (Web): July 21, 2004
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`Concise Synthesis and Structure−Activity Relationships of Combretastatin A-4
`Analogues, 1-Aroylindoles and 3-Aroylindoles, as Novel Classes of Potent
`Antitubulin Agents
`
`Jing-Ping Liou, Yi-Ling Chang, Fu-Ming Kuo, Chun-Wei Chang, Huan-Yi Tseng, Chiung-Chiu Wang, Yung-Ning Yang,
`Jang-Yang Chang, Shiow-Ju Lee, and Hsing-Pang Hsieh
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`Journal of Medicinal Chemistry 2004, 47, 17, 4247-4257 (Article)
`Publication Date (Web): July 17, 2004
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` Abstract
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`Three-Dimensional Quantitative Structure−Activity Relationship Analysis of a
`Set of Plasmodium falciparum Dihydrofolate Reductase Inhibitors Using a
`Pharmacophore Generation Approach
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`Marco Daniele Parenti, Sara Pacchioni, Anna Maria Ferrari, and Giulio Rastelli
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`Journal of Medicinal Chemistry 2004, 47, 17, 4258-4267 (Article)
`Publication Date (Web): July 16, 2004
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` Abstract
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`2-(1-Adamantyl)-4-(thio)chromenone-6-carboxylic Acids: Potent Reversible
`Inhibitors of Human Steroid Sulfatase
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`Amarylla Horvath, Peter Nussbaumer, Barbara Wolff, and Andreas Billich
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`Journal of Medicinal Chemistry 2004, 47, 17, 4268-4276 (Article)
`Publication Date (Web): July 9, 2004
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` Abstract
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`Phenoxyphenyl Pyridines as Novel State-Dependent, High-Potency Sodium
`Channel Inhibitors
`
`Bin Shao, Sam Victory, Victor I. Ilyin, R. Richard Goehring, Qun Sun, Derk Hogenkamp, Diane D. Hodges, Khondaker
`Islam, Deyou Sha, Chongwu Zhang, Phong Nguyen, Silvia Robledo, George Sakellaropoulos, and Richard B. Carter
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`Journal of Medicinal Chemistry 2004, 47, 17, 4277-4285 (Article)
`Publication Date (Web): July 16, 2004
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`
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`Identi cation of Structurally Diverse Growth Hormone Secretagogue Agonists
`by Virtual Screening and Structure−Activity Relationship Analysis of 2-
`Formylaminoacetamide Derivatives
`
`Miyuki Shoda, Takeo Harada, Yuji Kogami, Ryuichi Tsujita, Hirotada Akashi, Hiroyuki Kouji, Florence L. Stahura, Ling
`Xue, and Jürgen Bajorath
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`Journal of Medicinal Chemistry 2004, 47, 17, 4286-4290 (Article)
`Publication Date (Web): July 13, 2004
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` Abstract
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`Piperazine Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and
`Selective Adenosine A Receptor Antagonists
`2a
`
`Chi B. Vu, Bo Peng, Gnanasambandam Kumaravel, Glenn Smits, Xiaowei Jin, Deepali Phadke, Thomas Engber,
`Carol Huang, Jennifer Reilly, Stacy Tam, Donna Grant, Gregg Hetu, Liqing Chen, Jianbo Zhang, and Russell C. Petter
`
`Journal of Medicinal Chemistry 2004, 47, 17, 4291-4299 (Article)
`Publication Date (Web): July 13, 2004
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` Abstract
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`Journal of Medicinal Chemistry | Vol 47, No 17
`Fluorescent Pirenzepine Derivatives as Potential Bitopic Ligands of the Human
`M1 Muscarinic Receptor
`
`
`Chouaib Tahtaoui, Isabelle Parrot, Philippe Klotz, Fabrice Guillier, Jean-Luc Galzi, Marcel Hibert, and Brigitte Ilien
`
`Journal of Medicinal Chemistry 2004, 47, 17, 4300-4315 (Article)
`Publication Date (Web): July 16, 2004
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` Abstract
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` Full text
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` ABSTRACT
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`Tetramethylcyclopropyl Analogue of a Leading Antiepileptic Drug, Valproic
`Acid. Synthesis and Evaluation of Anticonvulsant Activity of Its Amide
`Derivatives
`
`Eyal Sobol, Meir Bialer, and Boris Yagen
`
`Journal of Medicinal Chemistry 2004, 47, 17, 4316-4326 (Article)
`Publication Date (Web): July 20, 2004
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` Abstract
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` Full text
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` ABSTRACT
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`Zinc Ion Dependent B-Cell Epitope, Associated with Primary Sjogren's
`Syndrome, Resides within the Putative Zinc Finger Domain of Ro60kD
`Autoantigen: Physical and Immunologic Properties
`
`John G. Routsias, Aggeliki Kosmopoulou, Athina Makri, Eugenia Panou-Pomonis, Constantinos Sakarellos, Maria
`Sakarellos-Daitsiotis, Haralampos M. Moutsopoulos, and Athanasios G. Tzioufas
`
`Journal of Medicinal Chemistry 2004, 47, 17, 4327-4334 (Article)
`Publication Date (Web): July 17, 2004
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`Journal of Medicinal Chemistry | Vol 47, No 17
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`BRIEF ARTICLES
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`O-Alkoxyamidine Prodrugs of Furamidine: In Vitro Transport and Microsomal
`Metabolism as Indicators of in Vivo E cacy in a Mouse Model of Trypanosoma
`brucei rhodesiense Infection
`
`John H. Ansede, Mariappan Anbazhagan, Reto Brun, Judy D. Easterbrook, James Edwin Hall, and David W. Boykin
`
`Journal of Medicinal Chemistry 2004, 47, 17, 4335-4338 (Brief Article)
`Publication Date (Web): July 16, 2004
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`Glucagon-like Peptide-1: The Basis of a New Class of Treatment
`for Type 2 Diabetes
`Lotte Bjerre Knudsen
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` Cite this: J. Med. Chem. 2004, 47, 17, 4128–4134
`Publication Date: July 20, 2004
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`https://doi.org/10.1021/jm030630m
`Copyright © 2004 American Chemical Society
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`Glucagon-like Peptide-1: The Basis of a New Class of Treatment for Type 2 Diabetes | Journal of Medicinal Chemistry
`SUBJECTS:
`Anatomy, Carbohydrates,
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`Note: In lieu of an abstract, this is the article's first page.
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`Glucagon-like Peptide-1: The Basis of a New Class of Treatment for Type 2 Diabetes | Journal of Medicinal Chemistry
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`
`5. Michaela Prothiwa, Ismail Syed, Mark O. Huising, Talitha van der Meulen, Cynthia J. Donaldson, Sunia A.
`Trauger, Barbara B. Kahn, and Alan Saghatelian . Data-Driven Synthesis of Proteolysis-Resistant Peptide
`Hormones. Journal of the American Chemical Society 2014, 136 (51) , 17710-17713.
`https://doi.org/10.1021/ja5065735
`
`6. Alessandro Angelini, Julia Morales-Sanfrutos, Philippe Diderich, Shiyu Chen, and Christian Heinis . Bicyclization
`and Tethering to Albumin Yields Long-Acting Peptide Antagonists. Journal of Medicinal Chemistry 2012, 55 (22) ,
`
`https://pubs.acs.org/doi/10.1021/jm030630m
`
`4/15
`
`SUN EXHIBIT 1085, IPR2024-00107, PAGE 23
`
`
`
`Glucagon-like Peptide-1: The Basis of a New Class of Treatment for Type 2 Diabetes | Journal of Medicinal Chemistry
`3/13/23, 9:12 AM
`10187-10197. https://doi.org/10.1021/jm301276e
`
`
`7. He Meng, Subrahmanian Tarakkad Krishnaji, Martin Beinborn and Krishna Kumar . In uence of Selective
`Fluorination on the Biological Activity and Proteolytic Stability of Glucagon-like Peptide-1. Journal of Medicinal
`Chemistry 2008, 51 (22) , 7303-7307. https://doi.org/10.1021/jm8008579
`
`8. Bong Chan Kim, Kyu-Young Kim, Hee Bong Lee and Hyunik Shin. Development of a Kilogram-Scale Synthesis of
`cis-LC15-0133 Tartrate, a Potent Dipeptidyl Peptidase IV Inhibitor. Organic Process Research & Development 2008,
`12 (4) , 626-631. https://doi.org/10.1021/op800076r
`
`9. Les P. Miranda, Katherine A. Winters, Colin V. Gegg, Ankita Patel, Jennifer Aral, Jason Long, Jingwen Zhang,
`Stephanie Diamond, Mark Guido, Shanaka Stanislaus, Mark Ma, Hongyan Li, Mark J. Rose, Leszek Poppe and
`Murielle M. Véniant. Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives
`with Increased Plasma Stability and Prolonged in Vivo Activity. Journal of Medicinal Chemistry 2008, 51 (9) , 2758-
`2765. https://doi.org/10.1021/jm701522b
`
`10. Dooseop Kim, Jennifer E. Kowalchick, Linda L. Brockunier, Emma R. Parmee, George J. Eiermann, Michael H.
`Fisher, Huaibing He, Barbara Leiting, Kathryn Lyons, Giovanna Scapin, Sangita B. Patel, Aleksandr Petrov, KellyAnn
`D. Pryor, Ranabir Sinha Roy, Joseph K. Wu, Xiaoping Zhang, Matthew J. Wyvratt, Bei B. Zhang, Lan Zhu, Nancy A.
`Thornberry and Ann E. Weber. Discovery of Potent and Selective Dipeptidyl Peptidase IV Inhibitors Derived from β-
`Aminoamides Bearing Subsituted Triazolopiperazines. Journal of Medicinal Chemistry 2008, 51 (3) , 589-602.
`https://doi.org/10.1021/jm070330v
`
`11. Santanu Mukherjee,, Jung Woon Yang,, Sebastian Hoffmann, and, Benjamin List. Asymmetric Enamine
`Catalysis. Chemical Reviews 2007, 107 (12) , 5471-5569. https://doi.org/10.1021/cr0684016
`
`12. Yaseen A. M. M. Elshaier, Ashraf A. Aly, Mohamed Abd El-Aziz, Hazem M. Fathy, Alan B. Brown, Mohamed
`Ramadan. A review on the synthesis of heteroannulated quinolones and their biological activities. Molecular
`Diversity 2022, 26 (4) , 2341-2370. https://doi.org/10.1007/s11030-021-10332-1
`
`13. Tanvi A. Deshpande, Jimena Martínez-Málaga, Ronny Priefer. Dithiocarbamates as potential PTP1B inhibitors
`for diabetes management. Results in Chemistry 2022, 4 , 100372. https://doi.org/10.1016/j.rechem.2022.100372
`
`14. Divya J. Jethava, Mayuri A. Borad, Manoj N. Bhoi, Prachi T. Acharya, Zeel A. Bhavsar, Hitesh D. Patel. New
`dimensions in triazolo[4,3-a]pyrazine derivatives: The land of opportunity in organic and medicinal chemistry.
`Arabian Journal of Chemistry 2020, 13 (12) , 8532-8591. https://doi.org/10.1016/j.arabjc.2020.09.038
`
`15. Yoshio Hayashi, Kyohei Muguruma. Basic Research in Antibody-dependent Drug Delivery Technology Based
`on IgG-binding Peptide. Drug Delivery System 2020, 35 (3) , 191-199. https://doi.org/10.2745/dds.35.191
`
`16. Julia Moellmann, Barbara Mara Klinkhammer, Julia Onstein, Robert Stöhr, Vera Jankowski, Joachim
`Jankowski, Corinna Lebherz, Frank Tacke, Nikolaus Marx, Peter Boor, Michael Lehrke. Glucagon-Like Peptide 1 and
`Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy. Diabetes 2018, 67 (11) , 2410-2419.
`https://doi.org/10.2337/db17-1212
`
`https://pubs.acs.org/doi/10.1021/jm030630m
`
`5/15
`
`SUN EXHIBIT 1085, IPR2024-00107, PAGE 24
`
`
`
`3/13/23, 9:12 AM
`Glucagon-like Peptide-1: The Basis of a New Class of Treatment for Type 2 Diabetes | Journal of Medicinal Chemistry
`17. Marya, Haroon Khan, Seyed Mohammad Nabavi, Solomon Habtemariam. Anti-diabetic potential of peptides:
`Future prospects as therapeutic agents. Life Sciences 2018, 193 , 153-158.
`https://doi.org/10.1016/j.lfs.2017.10.025
`
`
`
`18. H. Chilukuri, M. J. Kulkarni, M. Fernandes. Revisiting amino acids and peptides as anti-glycation agents.
`MedChemComm 2018, 9 (4) , 614-624. https://doi.org/10.1039/C7MD00514H
`
`19. Jian Wang, Tailang Yin, Xuwen Xiao, Dan He, Zhidong Xue, Xinnong Jiang, Yan Wang. StraPep: a structure
`database of bioactive peptides. Database 2018, 2018 https://doi.org/10.1093/database/bay038
`
`20. Woo Young Kwak, Hui Yeon Mok, Sung-Hwa Yoon. Improved Synthesis of ( R )-3-( t -Butoxycarbonylamino)-4-
`(2,4,5-tri uorophenyl)butanoic Acid as a Key Intermediate for the Synthesis of Sitagliptin. Bulletin of the Korean
`Chemical Society 2017, 38 (8) , 976-979. https://doi.org/10.1002/bkcs.11202
`
`21. Noé Quittot, Phuong Trang Nguyen, Armelle Tchoumi Nerée, Marc P. Lussier, Steve Bourgault. Identi cation of
`a conformational heparin-recognition motif on the peptide hormone secretin: key role for cell surface binding.
`Biochemical Journal 2017, 474 (13) , 2249-2260. https://doi.org/10.1042/BCJ20170035
`
`22. Louise Vedtofte, Filip K. Knop, Tina Vilsbøll. E cacy and safety of xed-ratio combination of insulin degludec
`and liraglutide (IDegLira) for the treatment of type 2 diabetes. Expert Opinion on Drug Safety 2017, 16 (3) , 387-
`396. https://doi.org/10.1080/14740338.2017.1288715
`
`23. Enkhjargal Tsend-Ayush, Chuan He, Mark A. Myers, Sof Andrikopoulos, Nicole Wong, Patrick M. Sexton,
`Denise Wootten, Briony E. Forbes, Frank Grutzner. Monotreme glucagon-like peptide-1 in venom and gut: one gene
`– two very different functions. Scienti c Reports 2016, 6 (1) https://doi.org/10.1038/srep37744
`
`24. F. P. M. O'Harte, M. T. Ng, A. M. Lynch, J. M. Conlon, P. R. Flatt. Dog sh glucagon analogues counter
`hyperglycaemia and enhance both insulin secretion and action in diet-induced obese diabetic mice. Diabetes,
`Obesity and Metabolism 2016, 18 (10) , 1013-1024. https://doi.org/10.1111/dom.12713
`
`25. Chris de Graaf, Dan Donnelly, Denise Wootten, Jesper Lau, Patrick M. Sexton, Laurence J. Miller, Jung-Mo Ahn,
`Jiayu Liao, Madeleine M. Fletcher, Dehua Yang, Alastair J. H. Brown, Caihong Zhou, Jiejie Deng, Ming-Wei Wang, .
`Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes.
`Pharmacological Reviews 2016, 68 (4) , 954-1013. https://doi.org/10.1124/pr.115.011395
`
`26. F.P.M. O'Harte, M.T. Ng, A.M. Lynch, J.M. Conlon, P.R. Flatt. Novel dual agonist peptide analogues derived from
`dog sh glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice.
`Molecular and Cellular Endocrinology 2016, 431 , 133-144. https://doi.org/10.1016/j.mce.2016.05.012
`
`27. Yutaka Seino, Shizuka Kaneko, Shuichi Fukuda, Takeshi Osonoi, Toshihiko Shiraiwa, Keiji Nishijima, Heidrun
`Bosch‐Traberg, Kohei Kaku. Combination therapy with liraglutide and insulin in Japanese patients with type 2
`diabetes: A 36‐week, randomized, double‐blind, parallel‐group trial. Journal of Diabetes Investigation 2016, 7 (4) ,
`565-573. https://doi.org/10.1111/jdi.12457
`
`28. Jonathan E. Wilson, Ravi Kurukulasuriya, Christopher Sinz, Matthew Lombardo, Kate Bender, Dann Parker,
`Edward C. Sherer, Melissa Costa, Karen Dingley, Xiaofang Li, Stanley Mitelman, Sharon Tong, Randal Bugianesi,
`
`https://pubs.acs.org/doi/10.1021/jm030630m
`
`6/15
`
`SUN EXHIBIT 1085, IPR2024-00107, PAGE 25
`
`
`
`Glucagon-like Peptide-1: The Basis of a New Class of Treatment for Type 2 Diabetes | Journal of Medicinal Chemistry
`3/13/23, 9:12 AM
`Anka Ehrhardt, Birgit Priest, Kevin Ratliff, Feroze Ujjainwalla, Ravi Nargund, William K. Hagmann, Scott
`Edmondson. Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the
`
`treatment of diabetes. Bioorganic & Medicinal Chemistry Letters 2016, 26 (12) , 2947-2951.
`https://doi.org/10.1016/j.bmcl.2016.04.018
`
`29. Stephen CL Gough, Rajeev Jain, Vincent C Woo. Insulin degludec/liraglutide (IDegLira) for the treatment of
`type 2 diabetes. Expert Review of Endocrinology & Metabolism 2016, 11 (1) , 7-19.
`https://doi.org/10.1586/17446651.2016.1113129
`
`30. Louise S. Dalbøge, Philip J. Pedersen, Gitte Hansen, Katrine Fabricius, Henrik B. Hansen, Jacob Jelsing, Niels
`Vrang, . A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid
`Modulating Agents. PLOS ONE 2015, 10 (8) , e0135634. https://doi.org/10.1371/journal.pone.0135634
`
`31. Tomoya Shiro, Takayuki Fukaya, Masanori Tobe. The chemistry and biological activity of heterocycle-fused
`quinolinone derivatives: A review. European Journal of Medicinal Chemistry 2015, 97 , 397-408.
`https://doi.org/10.1016/j.ejmech.2014.12.004
`
`32. Ram N. Kushwaha, Rohit Srivastava, Akansha Mishra, Arun K. Rawat, Arvind K. Srivastava, Wahajul Haq,
`Seturam B. Katti. Design, Synthesis, Biological Screening, and Molecular Docking Studies of Piperazine-Derived
`Constrained Inhibitors of DPP-IV for the Treatment of Type 2 Diabetes. Chemical Biology & Drug Design 2015, 85
`(4) , 439-446. https://doi.org/10.1111/cbdd.12426
`
`33. Michiko Amao, Yoshiro Kitahara, Ayaka Tokunaga, Kazutaka Shimbo, Yuzuru Eto, Naoyuki Yamada.
`Simultaneous quanti cation of intracellular and secreted active and inactive glucagon-like peptide-1 from cultured
`cells. Analytical Biochemistry 2015, 472 , 45-51. https://doi.org/10.1016/j.ab.2014.11.009
`
`34. Jeffrey-Tri Nguyen, Yoshiaki Kiso. Discovery of Peptide Drugs as Enzyme Inhibitors and Activators. 2015, 157-
`201. https://doi.org/10.1002/9781118995303.ch5
`
`35. Jeffrey-Tri Nguyen, Yoshiaki Kiso. Delivery of Peptide Drugs. 2015, 271-310.
`https://doi.org/10.1002/9781118995303.ch8
`
`36. Yohei Ikuma, Hitoshi Hochigai, Hidenori Kimura, Noriko Nunami, Tomonori Kobayashi, Katsuya Uchiyama,
`Takashi Umezome, Yasumitsu Sakurai, Naoyuki Sawada, Jun Tadano, Eiji Sugaru, Michiko Ono, Yuko Hirose,
`Hiroyuki Nakahira. Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase
`IV (DPP-4) inhibitors: Use of a carboxylate prodrug to improve bioavailability. Bioorganic & Medicinal Chemistry
`2015, 23 (4) , 779-790. https://doi.org/10.1016/j.bmc.2014.12.051
`
`37. Sinan Wang, Mingbo Su, Jiang Wang, Zeng Li, Lei Zhang, Xun Ji, Jingya Li, Jia Li, Hong Liu. ( R )-3-Amino-1-
`((3a S ,7a S )-octahydro-1 H -indol-1-yl)-4-(2,4,5-tri uorophenyl)butan-1-one derivatives as potent inhibitors of
`dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modeling. Bioorganic & Medicinal
`Chemistry 2014, 22 (23) , 6684-6693. https://doi.org/10.1016/j.bmc.2014.09.051
`
`38. Louise S. Dalbøge, Dorthe L. C. Almholt, Trine S. R. Neerup, Niels Vrang, Jacob Jelsing, Keld Fosgerau. The
`Novel GLP-1–Gastrin Dual Agonist ZP3022 Improves Glucose Homeostasis and Increases β -Cell Mass without
`
`https://pubs.acs.org/doi/10.1021/jm030630m
`
`7/15
`
`SUN EXHIBIT 1085, IPR2024-00107, PAGE 26
`
`
`
`Glucagon-like Peptide-1: The Basis of a New Class of Treatment for Type 2 Diabetes | Journal of Medicinal Chemistry
`3/13/23, 9:12 AM
`Affecting Islet Number in db/db Mice. Journal of Pharmacology and Experimental Therapeutics 2014, 350 (2) ,
`353-360. https://doi.org/10.1124/jpet.114.215293
`
`
`39. Steven M. Sparks, Grace Chen, Jon L. Collins, Dana Danger, Steven T. Dock, Channa Jayawickreme, Stephen
`Jenkinson, Christopher Laudeman, M. Anthony Leesnitzer, Xi Liang, Patrick Maloney, David C. McCoy, David
`Moncol, Vincent Rash, Thomas Rimele, Padmaja Vulimiri, James M. Way, Sean Ross. Identi cation of
`diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorganic & Medicinal Chemistry
`Letters 2014, 24 (14) , 3100-3103. https://doi.org/10.1016/j.bmcl.2014.05.012
`
`40. Chennam Setty Subbaiah, Wahajul Haq. E cient stereocontrolled synthesis of sitagliptin phosphate.
`Tetrahedron: Asymmetry 2014, 25 (13-14) , 1026-1030. https://doi.org/10.1016/j.tetasy.2014.06.001
`
`41. Anthony Heymann, Yasmin Maor, Inbal Goldstein, Lora Todorova, Perlit Schertz-Sternberg, Avraham Karasik.
`E cacy of Liraglutide in a Real-Life Cohort. Diabetes Therapy 2014, 5 (1) , 193-206.
`https://doi.org/10.1007/s13300-014-0062-2
`
`42. Omprakash Tanwar, Girdhar Singh Deora, Lalima Tanwar, Gautam Kumar, Sridhara Janardhan, Md. Mumtaz
`Alam, Md. Shaquiquzzaman, Mymoona Akhter. Novel hydrazine derivatives as selective DPP-IV inhibitors: ndings
`from virtual screening and validation through molecular dynamics simulations. Journal of Molecular Modeling
`2014, 20 (4) https://doi.org/10.1007/s00894-014-2118-7
`
`43. Odile E. Levy, Carolyn M. Jodka, Shijun Steven Ren, Lala Mamedova, Abhinandini Sharma, Manoj Samant,
`Lawrence J. D’Souza, Christopher J. Soares, Diane R. Yuskin, Li Jenny Jin, David G. Parkes, Krystyna Tatarkiewicz,
`Soumitra S. Ghosh, . Novel Exenatide Analogs with Peptidic Albumin Binding Domains: Potent Anti-Diabetic Agents
`with Extended Duration of Action. PLoS ONE 2014, 9 (2) , e87704. https://doi.org/10.1371/journal.pone.0087704
`
`44. Giuseppe Derosa, Pamela Ma oli. Pharmacotherapy for Obesity. 2014, 261-277. https://doi.org/10.1007/978-
`1-4939-0548-5_18
`
`45. M. Amiram, K.M. Luginbuhl, X. Li, M.N. Feinglos, A. Chilkoti. A depot-forming glucagon-like peptide-1 fusion
`protein reduces blood glucose for ve days with a single injection. Journal of Controlled Release 2013, 172 (1) ,
`144-151. https://doi.org/10.1016/j.jconrel.2013.07.021
`
`46. Mukesh C. Sharma. WITHDRAWN: Molecular modeling and pharmacophore approach substituted
`benzimidazole derivatives as dipeptidyl peptidase IV inhibitors. Journal of Saudi Chemical Society 2013,
`https://doi.org/10.1016/j.jscs.2013.10.008
`
`47. Yang Liu, Yizhe Wu, Haoshu Wu, Li Tang, Peng Wu, Tao Liu, Yongzhou Hu. Design, Synthesis, Biological
`Evaluation, and Docking Studies of ( S )-Phenylalanine Derivatives with a 2-Cyanopyrrolidine Moiety as Potent
`Dipeptidyl Peptidase 4 Inhibitors. Chemical Biology & Drug Design 2013, 82 (2) , 140-146.
`https://doi.org/10.1111/cbdd.12139
`
`48. Linrong Zhu, Yuanyuan Li, Ling Qiu, Mingbo Su, Xin Wang, Chunmei Xia, Yi Qu, Jingya Li, Jia Li, Bing Xiong,
`Jingkang Shen. Design and Synthesis of 4-(2,4,5-Tri uorophenyl)butane-1,3-diamines as Dipeptidyl Peptidase IV