CURRICULUM VITAE:
`
` WILLIAM J. JUSKO
` February 15, 2023
`
`Address:
`Department of Pharmaceutical Sciences, Pharmacy Building 404
`School of Pharmacy and Pharmaceutical Sciences
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`State University of NY at Buffalo, Buffalo, NY 14214-8033
`Phone (716) 645-2855; FAX (716) 829-6569
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`E-MAIL: wjjusko@buffalo.edu
`ORCID No. 0000-0003-4027-0550
`
`Weblinks:
`http://www.webofknowledge.com/ Jusko, W
`http://pharmacy.buffalo.edu/departments-offices/pharmaceutical-sciences.html
`http://www.researcherid.com/rid/G-4885-2015
`https://www.linkedin.com/pub/william-jusko/33/aa7/825
`https://www.facebook.com/william.jusko
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`Education:
`Salamanca High School, NY
`State University of New York at Buffalo
`State University of New York at Buffalo
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` 1956-1960 Secondary Education
` 1960-1965 B.S. Pharmacy
`1966-1969 Ph.D. 1970
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`Appointments:
`State University of New York at Buffalo, School of Pharmacy and Pharmaceutical Sciences,
` Department of Pharmaceutical Sciences
`SUNY Distinguished Professor
`UB Distinguished Professor
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`Professor
`Chair, Department of Pharmaceutical Sciences
`Director, Center of Excellence in Pharmacokinetics and Pharmacodynamics
`Vice-Chairman, Department of Pharmacy
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`Director, Doctor of Pharmacy Program
`Associate Professor of Pharmaceutics
`Assistant Professor of Pharmaceutics
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` Nov 2008 - present
` April 2007 - Nov 2008
` April 1977 - Apr 2007
` Jan 2001 – May 2016
` Dec 2005 -present
`April 1984 - Oct. 1986
` Sept. 1981 - Aug. 1986
` March 1974 - April 1977
` Aug.1972 - March 1974
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`Millard Fillmore Hospital, Buffalo, NY
`Director, Clinical Pharmacokinetics Laboratory
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`Mario Negri Institute for Pharmacological
`Research, Milan, Italy, Visiting Scientist
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`Veterans Administration Hospital, Boston, MA
`Clinical Pharmacology Section, Research Pharmacologist
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`Boston University School of Medicine
`Department of Pharmacology, Assistant Professor of Pharmacology
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`Boston Collaborative Drug Surveillance Program
`Boston University Medical Center, Research Associate
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`State University of New York at Buffalo
`Dept. of Pharmaceutics, Research Assistant
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` Aug. 1972 - Sept. 1981
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`Sept. 1978 - June 1979
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`Sept. 1969 - July 1972
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`June 1970 - July 1972
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`Sept. 1969 - July 1972
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` Sept. 1966 - Aug. 1969
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`MPI EXHIBIT 1006 PAGE 1
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` March 1966 - June 1968
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`Sept. 1962 - Feb. 1966
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`Children's Hospital of Buffalo, NY, Hospital Pharmacist
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`2
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`Soby's Pharmacy, Buffalo, NY, Pharmacist
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`Consultant:
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`Council for International Exchange of Scholars (Fulbright Scholar Program)
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`Medical Sciences Award Committee, 1980-84
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`National Institutes of Health, Pharmacology Study Section, 1980-84, 1997-01; Others: at present
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`Food and Drug Administration, CDER, Clinical Pharmacology Advisory Committee, 1999-2007
`Various pharmaceutical companies, 1978-present
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`Awards and Honors:
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`NIH Predoctoral Research Fellowship, 1966-1969.
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`Fulbright-Hays Award to Mario Negri Institute, Milan, Italy, 1978-1979.
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`Fellow, Academy of Pharmaceutical Sciences, 1980.
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`Rorer Award, Second Best paper in: Am. J. Gastroent., 1980, (Ref. 116).
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`Fellow, American Association for the Advancement of Science, 1985.
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`Fellow, American Association of Pharmaceutical Scientists, 1986.
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`Rawls-Palmer Award, Am. Soc. Clinical Pharmacology & Therapeutics, 1987.
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`Doctor Honoris Causae, Jagiellonian University, Krakow, Poland, 1987.
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`Russell R. Miller Award, Am. College of Clinical Pharmacy, 1988.
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`Citizen of the Year (Health/Medicine), Am-Pol Eagle, Buffalo, NY, 1987
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`Distinguished Service Award, Am. College Clinical Pharmacology, 1989.
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`Fellow, American College of Clinical Pharmacology, 1989.
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`Faculty Exchange Scholar, State University of New York, 1990
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`Kosciusko Award, General Pulaski Assn. of Niagara Frontier, 1996
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`Research Achievement Award in PPDM, AAPS, 1998
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`John G. Wagner Lectureship, University of Michigan, 1999
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`Sustained Achievement Award, University at Buffalo, 2002
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`Roland T Lakey Award Lecture, Wayne State University, 2003
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`Chancellor’s Award, University at Buffalo, 2003
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`ISI Most Highly Cited List in Pharmacology, 2003
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`MERIT Award, National Institutes of Health, 2005-2015
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`Volwiler Research Achievement Award, Am Assn Colleges of Pharmacy, 2005
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`Swintosky Distinguished Lecturer, University of Kentucky, 2006
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`Paul Ehrlich Magic Bullet Lifetime Achievement Award, Germany, Oct 2008
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`AAPS Meritorious Manuscript Award, 2008 (Ref. #469)
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`Leadership Award, American Society of Pharmacometrics, 2011
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`Distinguished Investigator Award, Am College of Clinical Pharmacology, Sept 2012
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`ASCPT Sheiner-Beal Pharmacometrics Award, March 2013
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`Collegium of Eminent Scientists, Kosciuszko Foundation, 2015
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`Doctor Honoris Causae, University of Paris Descartes, Sept. 2015
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`Fellow, International Society of Pharmacometrics, Oct. 2016
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`ASCPT/FDA William Abrams Lecture Award, May 2017
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`ASCPT Oscar B. Hunter Career Award in Therapeutics, March 2018
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`Lewis B. Sheiner Pharmacometrics Award, ISoP, Oct. 2019
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`AAPS Distinguished Pharmaceutical Scientist Award, Oct. 2020
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`Memberships:
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`American Association of Pharmaceutical Scientists (1986-present)
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`American Association of Colleges of Pharmacy (1972-present)
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`American Association for the Advancement of Science (1970-present)
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`American Society for Clinical Pharmacology and Therapeutics (1976-present)
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`American Pharmaceutical Association (1962-2012)
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`American Society for Microbiology (1975-1994)
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`American Society for Pharmacology and Experimental Therapeutics (1974-present)
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`Kappa Psi Pharmaceutical Fraternity (1962-1965)
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`Rho Chi Pharmaceutical Honor Society (1968)
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`American College of Clinical Pharmacy (1980-2009)
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`Federation Internationale Pharmaceutique (1980-2009)
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`American College of Clinical Pharmacology (1989-present)
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`European Federation for Pharmaceutical Sciences (1999-2009)
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`American Society of Pharmacometrics (2011-present)
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`Listings:
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`American Men and Women of Science, Who's Who (various venues)
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`Editorial Boards:
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`Journal of Pharmaceutical Sciences, 1976-81, 1992-2001
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`Antimicrobial Agents and Chemotherapy, 1978-1989
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`Biopharmaceutics and Drug Disposition, 1980-present
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`Journal of Pharmacokinetics and Pharmacodynamics, 1982-2005
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`Developmental Pharmacology and Therapeutics, 1980-1982
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`Drug Intelligence and Clinical Pharmacy, 1982-1987
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`Clinical Pharmacology and Therapeutics, 1986-2014
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`Journal of Clinical Pharmacology, 1993-present
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`American Journal of Therapeutics, 1994-present
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`Pharmaceutical Research, 1995-1997; Board of Consulting Editors, 2006-2014
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`Pharmacotherapy, 1995-2002
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`Journal of Pharmacology and Experimental Therapeutics, 1999-2015
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`Drug Metabolism and Pharmacokinetics (Japan), 2002-present
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`Open Access Bioinformatics, March 2009- present
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`Editor-in-Chief: Journal of Pharmacokinetics and Pharmacodynamics, 2005-2019
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`CPT: Pharmacometrics & Systems Pharmacology, 2012-2017
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`Current Pharmacology Reports, 2014-present
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`Other:
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`Registered Pharmacist in New York State (License No. 25534, March 1, 1966).
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`Laboratory Director in Toxicology, Certificate of Qualification No. 588, New York State Department of
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`Public Health (Issued August 13, 1973).
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`Patents:
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`1.
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`Benincosa L and Jusko WJ, Novel Method of Treatment, Patent No. WO 00/27341 (May 2000).
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`Publications:
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`1.
`2.
`3.
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`Levy G, and Jusko WJ, Effect of Viscosity on Drug Absorption, J. Pharm. Sci. 54: 219-225 (1965). PMID: 14293807
`Levy G., and Jusko WJ, Factors Affecting the Absorption of Riboflavin in Man, J. Pharm. Sci. 54: 285-289 (1966). PMID: 5960174
`Levy G and Jusko WJ, Apparent Renal Tubular Secretion of Riboflavin in Man, J. Pharm. Sci. 55: 1322 (1966). PMID: 5969798
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`Jusko WJ, and Levy G, Absorption, Metabolism, and Excretion of Riboflavin-5'-Phosphate in Man, J. Pharm. Sci. 56: 58-62 (1967). PMID:
`6030496
`Jusko WJ and Levy G, Effect of Probenecid on Riboflavin Absorption and Excretion in Man, J. Pharm. Sci. 56: 1145-1149 (1967). PMID:
`6049701
`Levy G and Jusko WJ, Case History of a Pharmaceutical Formulation Failure, Clin. Pharmacol. Ther. 8: 887-889 (1967). PMID: 6072698
`Jusko WJ and Levy G, Plasma Protein Binding of Riboflavin and Riboflavin-5'-Phosphate in Man, J. Pharm. Sci. 58: 58-62 (1969). PMID:
`5765837
`Levy G, Gibaldi M, and Jusko WJ, Multicompartment Pharmacokinetic Models and Pharmacologic Effects, J. Pharm. Sci. 58: 422-424 (1969).
`PMID: 5787438
`Jusko WJ, Ph.D. Thesis, The Absorption, Distribution, Metabolism, and Elimination of Riboflavin in Man. State University of New York at
`Buffalo (1970). Dissertation Abst. 31: 71-6083 (1971).
`Jusko WJ, Levy G, Yaffe SJ, and Gorodischer R, Effect of Probenecid on Renal Clearance of Riboflavin in Man, J. Pharm. Sci. 59: 473-477
`(1970). PMID: 5440673
`Jusko WJ, Rennick B, and Levy G, Renal Excretion Kinetics of Riboflavin in the Dog, Am. J. Physiol. 218: 1046-1053 (1970). PMID: 5435402
`Jusko WJ, Levy G, and Yaffe SJ, Effect of Age on lntestinal Absorption of Riboflavin in Humans, J. Pharm. Sci. 59: 487- 490 (1970). PMID:
`5440675
`Jusko WJ, Leonards JA, and Levy G., Riboflavin Distribution and Elimination in Two Functionally Anephric Human Patients, J. Pharm. Sci.
`59: 566-567 (1970). PMID: 5440692
`Jusko WJ and Levy G, Pharmacokinetic Evidence for Saturable Renal Tubular Reabsorption of Riboflavin, J. Pharm. Sci. 59: 765-772 (1970).
`PMID: 5463652
`Jusko WJ, Khanna N., Levy G, Stern L, and Yaffe SJ, Riboflavin Absorption and Excretion in the Neonate, Pediatrics 45: 945-949 (1970).
`PMID: 5422117
`Jusko WJ, Levy G., Yaffe SJ, and Allen J, Riboflavin Absorption in Children with Biliary Obstruction, Am. J. Dis. Child. 121: 48-52 (1971).
`PMID: 5539814
`Jusko WJ, Fluorometric Analysis of Ampicillin in Biological Fluids, J. Pharm. Sci. 60: 728-732 (1971). PMID: 5125772
`Jusko WJ, Pharmacodynamics of Chemotherapeutic Effects: Dose-TimeResponse Relationships for Phase-Nonspecific Agents, J. Pharm.
`Sci. 60: 892-895 (1971). PMID: 5166939
`Lewis GP, Jusko WJ, Burke CW, Graves L, and the Boston Collaborative Drug Surveillance Program, Prednisone Side-Effects and Serum-
`Protein Levels: A Collaborative Study, Lancet ii: 778-781 (1971). PMID: 4106604
`Jusko WJ, Lewis GP, and Dittert LW, Integral Coefficients of Multicompartment Pharmacokinetic Models: Application to Chemotherapy,
`Chemotherapy 17: 109-120 (1972). PMID: 5046835
`Jusko WJ, and Lewis GP, Precaution in Pharmacokinetic Evaluation of Ampicillin Precursors, Lancet i: 690-691 (1972). PMID: 4125194
`Jusko, W.J., and Lewis, G.P., Effect of Hepatic Disease on Liver Flavin and Protein Levels, Am J Clin Nutr 25: 265-268 (1972). PMID: 5011906
`Cohen JL, Jao JT, Jusko WJ, Pharmacokinetics of Cyclophosphamide in Man, Brit. J. Pharmacol. 43: 677-680 (1971). PMID: 5157730
`Lewis GP, Jusko WJ, Coughlin L, and Hartz S., The Contribution of Cigarette Smoking to Cadmium Accumulation in Man, Lancet i: 291-292
`(1972). PMID: 4109933
`Wizwer P, Lewis GP, Jusko WJ, and Slone D, A New System For Drug Ordering, Dispensing and Administration in Hospitals, Am. J. Hosp.
`Pharm. 29: 28-29 (1972). PMID: 5021507
`Jusko WJ and Gibaldi M, Effects of Change in Elimination on Various Parameters of the Two-Compartment Open Model, J. Pharm. Sci. 61:
`1270-1273 (1972). PMID: 5050376
`Wizwer P, Lewis GP, Jusko WJ, and Slone D, System Records Drug Orders, Drug Effects, J. Am. Hosp. Assn., 16: 86-94 (1972). PMID:
`5055143
`Jusko WJ, Pharmacodynamic Principles in Chemical Teratology: Dose-Response Relationships, J. Pharmacol. Exp. Ther. 183: 469-480 (1972).
`PMID: 4636387
`Jao JY, Jusko WJ, and Cohen JL, Phenobarbital Effects on Cyclophosphamide Pharmacokinetics in Man, Cancer Res. 32: 2761-2764 (1972).
`PMID: 4678592
`Jusko WJ, and Lewis GP, Comparison of Ampicillin and Hetacillin Pharmacokinetics in Man, J. Pharm. Sci. 62: 69-76 (1973). PMID: 4630199
`Jusko WJ, Lewis GP, and Schmitt G, Ampicillin and Hetacillin Pharmacokinetics in Normal and Anephric Subjects, Clin. Pharmacol. Ther. 14:
`90-99 (1973). PMID: 4345622
`Lewis GP, Jusko WJ, Coughlin LL, and Hartz S, Cadmium Accumulation in Man: lnfluence of Smoking, Occupation, Alcoholic Habit, and
`Disease, J. Chron. Dis. 26: 717-726 (1973). PMID: 4648516
`Jusko WJ, Pharmacokinetic Principles of Pediatric Pharmacology, Pediatr. Clin. North Am. 19: 81-100 (1972). PMID: 5049220
`Jusko WJ, Pharmacokinetic Principles in Chemical Teratology, Proc. Europ. Soc. Study Drug Toxicity 14: 9-19 (1973).
`Jusko WJ, The Bioavailability of Drug Products: Ampicillin APhA Pilot Project on Bioavailability, Am. Pharm. Assn., pp. 19-23 (1973).
`Jusko WJ, A Pharmacodynamic Model for Cell Cycle-Specific Chemotherapeutic Agents, J. Pharmacokin. Biopharm. 1: 175-200 (1973).
`Jusko WJ, Gretch M, and Gassett R, Precipitation of Diazepam from Intravenous Preparations, JAMA 225: 176 (1973). PMID: 4740282
`Jusko WJ, The Clinical Status of Predictive Pharmacokinetics, in: "Regulation and Control in Physiological Systems", A.S. Iberall and A.C.
`Guyton, editors, 1973, Instr. Soc. of America, Pittsburgh, pp. 57-60.
`Szefler SJ and Jusko WJ, Decreased Volume of Distribution of Digoxin in a Patient with Renal Failure, Res. Comm. Chem. Path. Pharmacol. 6:
`1095-1098 (1973). PMID: 4760884
`Jusko WJ, Rapporteur: in: "Pharmacology and Pharmacokinetics", T. Teorell, R.L. Dedrick, and P.G. Condliffe, editors, Plenum Press, New
`York (1974), pp. 312-313, 336-337, 348-349, 366-368.
`Jusko WJ, Szefler SJ, and Goldfarb AL, Pharmacokinetic Design of: Digoxin Dosage Regimens in Relation to Renal Function, J. Clin.
`Pharmacol. 14: 525-635 (1974). PMID: 4430731
`Jusko WJ and Weintraub M, Myocardial Distribution of Digoxin and Renal Function, Clin. Pharmacol. Ther. 16: 449-454 (1974). PMID:
`4414761
`Jusko WJ, Interpretation of Cell Proliferation Curves Using a Two-Compartment Cell Model, Math. Biosci. 21: 31-37 (1974).
`Gretch M, Jusko WJ, Interpretation of Drug Binding Changes in Relation to Protein Concentration, Br J Anesth 46: 545 (1974). PMID: 4458779
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`Jusko WJ, Clinical Pharmacokinetics of Digoxin, in: "Clinical Pharmacokinetics - A Symposium", G Levy, editor, APhA., Academy of
`Pharmaceutical Sciences, Washington, 1974, pp. 31-43.
`Jusko WJ, Pharmacokinetic Management of Antibiotic Therapy, in: "Clinical Pharmacokinetics - A Symposium", G.Levy, editor, A.Ph.A.
`Academy of Pharmaceutical Sciences, Washington, 1974, pp. 111-127.
`Jusko WJ, Conti DR, Molson A, Kuritzky P, Giller J, and Schultz R, Digoxin Absorption from Tablets and Elixir: The Effect of Radiation-
`Induced Malabsorption, JAMA 230: 1554-1555 (1974). PMID: 4479663
`Danish M, Schultz R, and Jusko WJ, Pharmacokinetics of Gentamicin and Kanamycin During Hemodialysis, Antimicrob. Ag. Chemother. 6:
`841-847 (1974). PMID: 4451356
`Jusko WJ, Slaunwhite WR, and Aceto T, Partial Pharmacodynamic Model for the Circadian-Episodic Secretion of Cortisol in Man, J. Clin.
`Endocrinol. Metab. 40: 278-289 (1975). PMID: 163972
`Garrettson LK and Jusko WJ, Diphenylhydantoin Elimination Kinetics in Overdosed Children, Clin. Pharmacol. Ther. 17: 481-491 (1975).
`PMID: 1122689
`Lalka D, Jusko WJ, and Bardos TJ, Reactions of 2,2-Dimethylaziridine-Type Alkylating Agents in Biological Systems. II. A Comparative
`Pharmacokinetic Study in Dogs, J. Pharm. Sci. 64: 230-235 (1975). PMID: 236372
`Jusko WJ, Factors Affecting the Pharmacokinetics of Some Psychoactive Drugs, Proc. of the Symposium: Clinical Pharmacology and
`Toxicology of Psychoactive Drugs, E.M. Sellers, ed, Addict Research Found, Toronto, pp.55-72 (1975).
`Jusko WJ and Levy G, Absorption, Protein Binding, and Elimination of Riboflavin, Chapter 4 in Riboflavin, Rivlin R.S., editor, Plenum Press,
`New York, 99-152 (1975).
`Jusko WJ, Gerbracht LM, Golden LH, and Koup J., Digoxin Concentrations in Serum and Saliva, Res. Comm. Chem. Path. Pharmacol. 10: 189-
`192 (1975). PMID: 1124317
`Jusko WJ, Mosovich LL, Gerbracht LM, Mattar ME, and Yaffe SJ, Enhanced Elimination of Dicloxacillin in Patients with Cystic Fibrosis,
`Pediatrics 56: 1038-1044 (1975). PMID: 1196754
`Koup JR, Jusko WJ, Elwood CM, and Kohli RK, Digoxin Pharmacokinetics: Role of Renal Failure in Dosage Regimen Design, Clin. Pharmacol.
`Ther. 18: 9-21 (1975). PMID: 1149366
`Koup JR, Jusko WJ, Goldfarb AL, pH-Dependent Secretion of Procainamide into Saliva, J. Pharm. Sci. 64; 2008-2010 (1975). PMID: 1514
`Koup JR, Greenblatt DJ, Jusko WJ, Smith TW, and Koch-Weser J, Pharmacokinetics of Digoxin in Normal Subjects After Intravenous Bolus
`and Infusion Doses, J. Pharmacokin. Biopharm. 3: 181-192 (1975). PMID: 1159622
`Lewis GP and Jusko WJ, Pharmacokinetics of Ampicillin in Cirrhosis, Clin. Pharmacol. Ther. l8: 475-484 (1975). PMID: 1164828
`Jusko WJ, Drug Dosage Adjustments in Diseased Patients, Rational Drug Therapy 10: 1-8 (1976). PMID: 951505
`Gorodischer R, Jusko WJ, and Yaffe SJ, Renal Clearance of Digoxin in Young Infants, Res. Comm. Chem. Path. Pharmacol. 16: 363-374 (1977).
`PMID: 847290
`Gorodischer R, Jusko WJ, and Yaffe SJ, Tissue and Erythrocyte Distribution of Digoxin in Infants, Clin. Pharmacol. Ther. 19: 256-263 (1976).
`PMID: 1261163
`Koup JR, DeLattre M, Jusko WJ, and Vance JW, Caution in the Use of Variable Heparin Strengths, Drug Intell. Clin. Pharm. 9: 387-388 (1975).
`Jusko WJ, Bioavailability Monograph on "Ampicillin", J. Am. Pharmaceut. Assn., NS 15: 591-594 (1975). PMID: 1184921
`Jusko WJ and Poliszczuk A, Analysis of Theophylline in Biological Fluids by HPLC, Dupont Liquid Chromatography Applications Report,
`DuPont Instruments, Wilmington, Del. (1975).
`Yurchak AM and Jusko WJ, Theophylline Secretion into Breast Milk, Pediatrics 57: 518-520 (1976). PMID: 1264548
`Jusko WJ, Baliah T, Kim KH, Gerbracht LM, and Yaffe SJ, Pharmacokinetics of Gentamicin During Peritoneal Dialysis in Children, Kidney
`International 9: 430-438 (1976). PMID: 940277
`Jusko WJ and Gretch M., Plasma and Tissue Protein Binding of Drugs in Pharmacokinetics, Drug Met. Rev. 5: 43-140 (1976). PMID: 829788
`& PMID: 780085
`Hunt SN, Jusko WJ, Yurchak AM, Effect of Smoking on Theophylline Disposition, Clin. Pharmacol. Ther. 19: 546-551 (1976). PMID: 1277710
`Thiessen JJ, Bernardo PD, Seitz J, and Jusko WJ, Prednisolone: Bioavailability Monograph, J. Am. Pharm. Assn. NS 16: 143-146 (1976).
`Jusko WJ, Bioavailability and Disposition Kinetics of Phenytoin in Man, In: "Quantitative Analytic Studies in Epilepsy", Kellaway P and
`Peterson I., editors, Raven Press, New York, 115-136 (1976).
`Jusko WJ, Koup JR, and Alvan G, Nonlinear Assessment of Phenytoin Bioavailability, J. Pharmacokin. Biopharm. 4: 327-336 (1976). PMID:
`978395
`Jusko WJ, Pharmacokinetics in Disease States Changing Protein Binding, Chapter 7, in: "The Effects of Disease States on Drug
`Pharmacokinetics," L Benet, editor, Acad. Pharmaceut. Sci., Washington, D.C., 99-123 (1976).
`Parsons RL, Jusko WJ, and Young JM, Pharmacokinetics of Antibiotic Absorption in Coeliac Disease, J. Antimicrob. Chemother. 2: 214-215
`(I976). PMID: 956085
`Koup JR, Schentag JJ, Vance JW, Kuritzky PM, Pyszczynski DR, and Jusko WJ, System for Clinical Pharmacokinetic Monitoring of
`Theophylline Therapy, Am. J. Hosp. Pharm. 33: 949-956 (1976). PMID: 790952
`Jusko WJ and Poliszczuk A, High Pressure Liquid Chromatographic and Spectrophotometric Assays for Theophylline in Biological Fluids, Am.
`J. Hosp. Pharm. 33: 1193-1196 (1976). PMID: 998637
`Giacoia G, Jusko WJ, Menke J, and Koup JR, Theophylline Pharmacokinetics in Premature Infants with Apnea, J. Ped. 89: 829-32 (1976). PMID:
`789845
`Yaffe SJ, Gerbracht LM, Mosovich LL, Mattar ME, and Jusko WJ, Methicillin Pharmacokinetics in Cystic Fibrosis, J. Inf. Dis. 135: 828-831
`(1977). PMID: 404369
`Jusko WJ, Koup JR, Vance JW, Kuritzky PM, and Schentag JJ, Intravenous Theophylline Therapy: Nomogram Guidelines, Ann. Int. Med., 86:
`400-404 (1977). PMID: 848801
`Schentag JJ and Jusko WJ, Gentamicin Persistence in the Body, The Lancet i: 486 (1977). PMID: 65590
`Rose JQ, Choi HK, Schentag JJ, Kinkel WR, and Jusko WJ, Intoxication Caused by Interaction of Chloramphenicol and Phenytoin, JAMA 237:
`2630-2631 (1977). PMID: 576989
`Resman BH, Blumenthal HP, and Jusko WJ, Breast-Milk Distribution of Theobromine from Chocolate, J. Ped. 91: 477-480 (1977). PMID:
`894424
`Schentag JJ, Jusko WJ, Plaut ME, Cumbo TJ, Vance JW, and Abrutyn E, Tissue Persistence of Gentamicin in Man, JAMA 238: 327-329 (1977).
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`6
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`PMID: 406431
`Schentag JJ, and Jusko WJ, Renal Clearance and Tissue Accumulation of Gentamicin in Man, Clin. Pharmacol. Ther. 22: 364-370 (1977). PMID:
`330081
`Schentag JJ, Jusko WJ, Vance JW, Cumbo TJ, Abrutyn E, DeLattre M, and Gerbracht LM, Gentamicin Disposition and Tissue Accumulation
`on Multiple Dosing, J. Pharmacokin. Biopharm. 5: 559-577 (1977). PMID: 599407
`Lima JJ, Kuritzky PM, Schentag JJ, and Jusko WJ, Fetal Uptake and Neonatal Disposition of Procainamide and NAPA: A Case Report, Pediatrics
`61: 491-493 (1978). PMID: 643424
`Lima JJ and Jusko WJ, Determination of Procainamide Acetylator Status, Clin. Pharmacol. Ther. 23: 25-29 (1978). PMID: 618707
`Jusko WJ, Role of Tobacco Smoking in Pharmacokinetics, J. Pharmacokin. Biopharm. 6: 7-39 (1978). PMID: 349132
`Lima JJ and Jusko WJ, Micromethod for Procainamide and Its Acetylated Metabolite by HPLC, In: GL Hawk, editor; Biological/Biochemical
`Application of Liquid Chromatography, Marcel Dekker,, New York, 10: 573-583 (1979).
`Gal P, Jusko WJ, Yurchak AM, and Franklin BA, Theophylline Disposition in Obesity, Clin Pharmacol.Ther 23: 438-444 (1978). PMID: 630791
`Mangione A, Imhoff TE, Lee RV, Shum LY, and Jusko WJ, Pharmacokinetics of Theophylline in Hepatic Disease, Chest 73: 616-622 (1978).
`PMID: 648214
`Jusko WJ, Schentag JJ, Clark JH, Gardner M, and Yurchak AM, Enhanced Biotransformation of Theophylline in Marihuana and Tobacco
`Smokers, Clin. Pharmacol. Ther. 24: 406-410 (1978). PMID: 688731
`Schentag JJ, Lasezkay G, Plaut ME, Jusko WJ, and Cumbo TJ, Tissue Accumulation and Prolonged Washout of Gentamicin and Tobramycin in
`Humans, Current Chemotherapy 2: 957-959 (1978).
`Colburn WA, Schentag JJ, Jusko WJ, and Gibaldi, M., A Model for the Prospective Identification of the Pre-Nephrotoxic State During
`Gentamicin Therapy, J. Pharmacokin. Biopharm. 6: 179-186 (1978). PMID: 671224
`MacKichan JJ, Pyszczynski DR, and Jusko WJ, Analysis and Disposition of Low Dose Oral Propranolol, Res. Commun. Chem. Pathol.
`Pharmacol. 20: 531-538 (1978). PMID: 674830
`Owerbach J, Johnson NF, Bates TR, Pieniaszek HJ, and Jusko WJ, High Performance Liquid Chromatograph Assay of Sulfapyridine and
`Acetylsulfapyridine in Biological Fluids, J. Pharm. Sci. 67: 1250-53 (1978). PMID: 690830
`Schentag JJ, Lasezkay G, Cumbo TJ, Plaut ME, and Jusko WJ, Accumulation Pharmacokinetics of Tobramycin, Antimicrob. Agents Chemother.
`13: 649-656 (1978). PMID: 666293
`Rose JQ. Barron SA, and Jusko WJ, Phenytoin Disposition in Smokers and Nonsmokers, Int. J. Clin. Pharmacol. Biopharm. 16: 547-550 (1978).
`PMID: 730422
`Jusko WJ, Therapeutic Implications of Digoxin Kinetics in Impaired Renal Function, Proc. Int. Symposium on Cardiac Glycosides, G Bodem
`and HJ Dengler, Eds., Bonn-1977, pp. 265-272 (1978).
`Rose JQ and Jusko WJ, Corticosteroid Analysis in Biological Fluids by High Performance Liquid Chromatography, J. Chromatogr. 162: 273-
`280 (1979). PMID: 528595
`Schentag JJ, Lasezkay G, Plaut ME, Jusko WJ, and Cumbo TJ, Comparative Tissue Accumulation of Gentamicin and Tobramycin in Patients,
`J. Antimicrob. Chemother. 4 (Suppl. A): 23-30 (1978). PMID: 659346
`Lima JJ, Conti DR, Goldfarb AL, Golden LH, and Jusko WJ, Pharmacokinetic Approach to Intravenous Procainamide Therapy, Europ. J. Clin.
`Pharmacol. 13: 303-308 (1978). PMID: 668789
`Schentag JJ, Cumbo TJ, Jusko WJ, Plaut ME, Gentamicin Tissue Accumulation and Nephrotoxic Reactions, JAMA 240: 2067-9 (1978). PMID:
`702701
`Lima JJ, Conti DR, Goldfarb AL, Tilstone WJ, Golden LH, and Jusko WJ, Clinical Pharmacokinetics of Procainamide lnfusions in Relation to
`Acetylator Phenotype, J. Pharmacokin. Biopharm. 7: 69-85 (1979). PMID: 458558
`Schentag JJ, Jusko WJ, Vance J, Cumbo TJ, Abrutyn E., and Plaut ME, Aminoglycoside Nephrotoxicity in Relation to Tissue Accumulation, In:
`Nephrotoxicity, J-P Fillastre, Ed., Masson Publ. Inc., New York (1978), pp. 63-82.
`Schentag JJ, Sutfin TA, Plaut ME, and Jusko WJ, Early Detection of Aminoglycoside Nephrotoxicity with Urinary Beta Microglobulin, J. Med.
`9: 201-210 (1978). PMID: 84037
`Lima JJ, Goldfarb AL, Conti DR, Golden LH, Bascomb BL, Benedetti GM, and Jusko WJ, Safety and Efficacy of Procainamide Infusions, Am.
`J. Cardiol. 43: 98-105 (1979). PMID: 758776
`Sutfin TA and Jusko WJ, High Performance Liquid Chromatographic Assay for Imipramine, Desipramine, and Their 2-Hydroxylated
`Metabolites, J. Pharm. Sci. 68: 703-705 (1979). PMID: 458567
`MacKichan JJ, Pyszczynski DR, and Jusko WJ, Dose-Dependent Disposition of Oral Propranolol in Normal Subjects, Biopharm. Drug Disp. 1:
`159-166 (1980). PMID: 7448344
`Jusko WJ, Influence of Cigarette Smoking on Drug Metabolism in Man, Drug Metab. Rev. 9: 221-236 (1979). PMID: 385272
`MacKichan JJ and Jusko WJ, Stability of Hydrocortisone in Human Feces, J. Pharm. Sci. 68: 623-625 (1979). PMID: 430502
`Hilligoss DM, Jusko WJ, Hart BA, Koup JR, and Giacoia G, Factors Affecting Theophylline Pharmacokinetics in Premature Infants with Apnea,
`Dev. Pharmacol. Ther. 1: 6-15 (1980). PMID: 7438966
`Plaut ME, Schentag JJ, and Jusko WJ, Aminoglycoside Nephrotoxicity: Comparative Assessment in Critically Patients, J. Med. 10: 257-266
`(1979). PMID: 294466
`Potter WZ, Calil HM, Zavadil AP, Jusko WJ, Sutfin T, Rapoport JL, and Goodwin FK. Steady-State Concentrations of Hydroxylated Metabolites
`of Tricyclic Antidepressants in Patients: Relationship to Clinical Effect, Psychopharmacol. Bull. 16: 32-34 (1980).
`Lima JJ, Giller J, MacKichan JJ, and Jusko WJ, Bioavailability of Hydrocortisone Retention Enemas in Normal Subjects, Am. J. Gastroenterol.
`73: 232-237 (1980). PMID: 7405924
`Jusko WJ, Concepts for Population Pharmacokinetics of Theophylline, In: 25 Jahre Pharmakokinetik (Symposium), E Gladke and G Hermin,
`Eds., Gustov Fisher Verlag, Stuttgart, pp. 181-189 (1980).
`Jusko WJ, Gardner M, Mangione A, Schentag JJ, Koup JR, and Vance JW, Factors Affecting Theophylline Clearances: Age, Tobacco,
`Marihuana, Cirrhosis, Congestive Heart Failure, Obesity, Oral Contraceptives, Benzodiazepines, Barbiturates, and Ethanol, J. Pharm. Sci. 68:
`1358-1366 (1979). PMID: 41932
`Schentag JJ, Gengo FM, Plaut ME, Danner D, Mangione A, and Jusko WJ., Urinary Casts as an Indicator of Renal Tubular Damage in Patients,
`Antimicrob. Ag. Chemother. 16: 468-474 (1979). PMID: 518076
`MacKichan JJ, Jusko WJ, Duffner PK, and Cohen ME, Liquid Chromatographic Assay of Diazepam and Its Major Metabolites in Plasma, Clin.
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`7
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`Chem. 25: 856-859 (1979). PMID: 448518
`Rose JQ, Yurchak AM, Jusko WJ, and Powell D, Bioavailability and Disposition of Prednisone and Prednisolone from Prednisone Tablets,
`Biopharm. Drug Disp. 1: 247-258 (1980).
`Rose JQ. Yurchak AM, Meikle AQ, and Jusko WJ, Effect of Smoking on Prednisone, Prednisolone, and Dexamethasone Pharmacokinetics, J.
`Pharmacokin. Biopharm. 9: 1-14 (1981). PMID: 7229914
`DeVane CL, Wolin RE, and Jusko WJ, Pharmacokinetic Basis for Predicting Steady-State Serum Drug Concentrations of Imipramine from
`Single Dose Data, Res. Commun. Psychopharm, 3: 353-357 (1979). PMID: 548214
`Lima JJ and Jusko WJ, The Bioavailability of Hydrocortisone Retention Enemas in Relation to Absorption Kinetics, Clin. Pharmacol. Ther. 28:
`262-269 (1980). PMID: 7398193
`Janssen FW, JuskoWJ, Chiang ST, Kirkman SK, Southgate PJ, Coleman AJ, and Ruelius HW, Metabolism and Pharmacokinetics of Oxaprozin
`in Normal Subjects, Clin. Pharmacol. Ther. 27: 352-362 (1980). PMID: 7357792
`Rocci ML, Johnson NF, and Jusko WJ, Serum Protein Binding of Prednisolone in Four Species, J. Pharm. Sci. 69: 977-978 (1980). PMID:
`7400951
`Jusko WJ, Therapeutic Drug Monitoring: Pharmacokinetic Aspects, In: Breimer, DD, Editor, Towards Better Safety of Drugs and
`Pharmaceutical Products, pp. 153-165, Elvesier/North-Holland Biomedical Press (1980).
`Assael BM, Cavanna G, Jusko WJ, Marini A, Parini R, Sereni F, and Vigano A., Multiexponential Elimination of Gentamicin. A Kinetic Study
`During Development, Dev. Pharmacol. Ther. 1: 171-181 (1980). PMID: 6927546
`Jusko WJ and Rose JQ, Monitoring Prednisone and Prednisolone, Ther. Drug Monit. 2: 169-176 (1980). PMID: 6762710
`Rose JQ, Nickelsen, JA, Middleton E, Yurchak AM, Park B, and Jusko WJ, Prednisolone Disposition in Steroid Dependent Asthmatics, J. Allerg.
`Clin. Immunol. 66: 366-373 (1980). PMID: 7440853
`Tognoni G., Latini R., and Jusko WJ, Editors, Frontiers in Therapeutic Drug Monitoring, Raven Press, NY (1980).
`Szefler SJ, Rose JQ, Ellis EF, Spector SL, Green AW, and Jusko WJ, The Effect of Troleandomycin on Methylprednisolone Disposition, J.
`Allerg. Clin. Immunol. 66: 447-451 (1980). PMID: 6968763
`Jusko WJ, Guidelines for Collection and Pharmacokinetic Analysis of Drug Disposition Data, In: Evans, WE., Schentag J.J, and Jusko WJ, Eds.,
`Applied Pharmacokinetics, Appl. Ther. Inc., San Francisco, pp. 639-680 (1980).
`Evans WE, Schentag JJ, and Jusko WJ, Eds, Applied Pharmacokinetics, Applied Therapeutics Inc., San Francisco (1980).
`Rocci ML, Szefler SJ, Acara M, and Jusko WJ, Prednisolone Metabolism and Excretion in the Isolated Perfused Rat Kidney, Drug Met. Disp.
`9: 177-182 (1981). PMID: 6113924
`DeVane CL, Wolin RE, Rovere RA, Panahon NC, Sutfin TA, and Jusko WJ, Excessive Plasma Concentrations of Tricyclic Antidepressants
`Resulting from Usual Doses: A Report of Six Cases, J. Clin. Psych. 42: 143-147 (1981). PMID: 7204359
`Rose JQ, Yurchak AM, and Jusko WJ, Dose-Dependent Pharmacokinetics of Prednisone and Prednisolone in Man, J. Pharmacokin. Biopharm.
`9: 389-417 (1981). PMID: 7310640
`Rose JQ. Nickelsen JA, Ellis EF, Middleton E, Park B, and Jusko WJ, Prednisolone Disposition in Steroid Dependent Asthmatic Children, J.
`Allerg. Clin. Immunol. 67: 188-193 (1981). PMID: 7462536
`DeVane CL, Savett M, and Jusko WJ, Desipramine and 2-HydroxyDesipramine Pharmacokinetics in Normal Volunteers, Eur. J. Clin.
`Pharmacol. 19: 61-64 (1981). PMID: 7461025
`DeVane CL and Jusko WJ, Pharmacokinetics of High Clearance Drugs and Their Metabolites, In: Usdin,E., Dahl SG., Gram L., Linghaerde 0.,
`Eds., Clinical Pharmacology in Psychiatry, MacMillan &Co., London, pp. 253-261 (1981).
`DeVane CL and Jusko WJ, Plasma Concentration Monitoring of Hydroxylated Metabolites of Imipramine and Desipramine, Drug Intell. Clin.
`Pharm. 15: 263-266 (1981). PMID: 7274042
`Janicke DM, Mangione A, Schultz R, and Jusko WJ, Mezlocillin Disposition in Chronic Hemodialysis Patients, Antimicrob. Agents Chemother.
`20: 590-594 (1981). PMID: 6459760
`Jusko WJ, Smoking and Drug Response, Pharmacy Int. 2: 10-13 (1981).
`Rocci ML and Jusko WJ, Analysis of Predniso