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Patent Owner

10x Genomics, Inc.

Petitioner

Parse Biosciences, Inc.

Assignee

POPULATION GENETICS TECHNOLOGIES LTD.

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Parse Biosciences, Inc. v. 10x Genomics, Inc.

IPR2023-00955 | Patent Trial and Appeal Board

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Filed May 25, 2023

Terminated Jan. 31, 2025

Judges Devon Zastrow Newman, Michael Fitzpatrick, and Sheridan Snedden

Case Type Inter Partes Review

Status Final Written Decision - Appealed

Challenged Patent 16/194,047

Patent No. 10,240,197 assignments

Tech Center 1600

Art Unit 1639

Inventors Sydney Brenner, Gi Mikawa, Robert Osborne, Andrew Slatter

Last Updated: 54 minutes ago

Filing Date	#	Filing and Exhibits
Entries matching. Show All.
4/3/2025	04-03-2025-Patent_Owner	Event: Notice of Appeal Patent Owner Notice: notice of appeal 47: Patent Owner's Notice of Appeal
1/31/2025	01-31-2025-Board	Event: Final Written Decision (All Claims Cancelled) Board Final Written Decision: original 46: Judgment Final Written Decision
12/9/2024	12-09-2024-Board	Board Other: Hearing transcript 45: Other: Hearing transcript
11/5/2024	11-05-2024-Patent_Owner	Patent Owner Other: other 44: Patent Owner's Submission of Unresolved Objections to Petitioner's Demonstratives
11/1/2024	11-01-2024-Petitioner	Petitioner Other: other 43: Petitioner's Oral Argument Demonstratives
11/1/2024	11-01-2024-Patent_Owner	Patent Owner Other: other 42: Patent Owner's Oral Hearing Demonstratives
10/25/2024	10-25-2024-Petitioner	Petitioner Reply to Opposition 41: Petitioner's Reply to Patent Owner's Opposition to Motion to Exclude
10/25/2024	10-25-2024-Patent_Owner	Patent Owner Reply to Opposition 40: Patent Owner's Reply in Support of its Motion to Exclude Patent Owner Exhibit 2041: EX2041 - Wayback Archive Records for https://link.springer.com/article/10.1007/s10528-007-9114-x Patent Owner Exhibit 2042: EX2042 - Wayback Archive Records for https://pubmed.ncbi.nlm.nih.gov/17955361/ Patent Owner Exhibit 2043: EX2043 - Wayback Archive Records for https://www.researchgate.net/publication/5891130_Encoding_PCR_Products_with _Batch-stamps_and_Barcodes
10/18/2024	10-18-2024-Patent_Owner	Patent Owner Opposition 39: Patent Owner's Opposition to Petitioner's Motion to Exclude
10/18/2024	10-18-2024-Petitioner	Petitioner Opposition 38: Petitioner's Opposition to Patent Owner's Motion to Exclude Petitioner Exhibit 1090: EX1090
10/11/2024	10-11-2024-Petitioner	Petitioner Motion: Other 37: Petitioner's Motion to Exclude
10/11/2024	10-11-2024-Patent_Owner	Patent Owner Motion: Other 36: Patent Owner's Motion to Exclude
9/24/2024	09-24-2024-Board	Board Order: Other 35: Order Setting Oral Argument
9/20/2024	09-20-2024-Patent_Owner	Patent Owner Other: other 34: Patent Owner's Request for Oral Hearing
9/20/2024	09-20-2024-Petitioner	Petitioner Other: other 33: Petitioner's Objections to Evidence
9/17/2024	09-17-2024-Petitioner	Petitioner Notice: Other 32: Petitioner's Request for Oral Argument
9/13/2024	09-13-2024-Patent_Owner	Patent Owner Other: other 31: Patent Owner's Sur-Reply Patent Owner Exhibit 2040: EX2040 - IPR2023-00955 September 3, 2024 Deposition Transcript of Gregory Cooper, Ph.D. Patent Owner Exhibit 2102: EX2102 - C. Wansgasnuwat et al, Efficient and cost-effective bacterial mRNA sequencing from low input samples through ribosomal RNA depletion, BMC Genomics (2020) 21:717 (marked as EX2102 in Dr. Cooper’s September 3, 2024 deposition (EX2040)) Patent Owner Exhibit 2103: V. Llorens-Rico et al, Single-cell approaches in human microbiome research, Cell (2022) 185:2725 (marked as EX2103 in Dr. Cooper’s September 3, 2024 deposition (EX2040))
8/23/2024	08-23-2024-Patent_Owner	Patent Owner Notice: Notice of deposition 30: Deposition Notice of Gregory Cooper, Ph.D.
8/22/2024	08-22-2024-Petitioner	Petitioner Notice: Other 29: Petitioner's Notice of Filing Stipulation Regarding Defenses in Co-Pending District Court Litigation Petitioner Exhibit 1088: EX1088 Petitioner Exhibit 1089: EX1089
8/21/2024	08-21-2024-Board	Board Order: on Motion 28: ORDER Granting Patent Owner’s Motion to Terminate Proceeding But Holding Termination in Abeyance Pending Action by Petitioner 37 C.F.R. § 42.5
8/9/2024	08-09-2024-Patent_Owner	Patent Owner Other: other 27: Patent Owner's Objections to Evidence
8/6/2024	08-06-2024-Patent_Owner	Patent Owner Reply to Opposition 26: Patent Owner's Reply in Support of its Motion to Terminate Proceedings
8/2/2024	08-02-2024-Petitioner	Petitioner Pet Reply to PO Resp 25: Petitioner's Reply to Patent Owner's Response Petitioner Exhibit 1069: EX1069 Petitioner Exhibit 1070: EX1070 Petitioner Exhibit 1071: EX1071 Petitioner Exhibit 1072: EX1072 Petitioner Exhibit 1073: EX1073 Petitioner Exhibit 1074: EX1074 Petitioner Exhibit 1075: EX1075 Petitioner Exhibit 1076: EX1076 Petitioner Exhibit 1079: EX1079 Petitioner Exhibit 1080: EX1080 Petitioner Exhibit 1081: EX1081 Petitioner Exhibit 1082: EX1082 Petitioner Exhibit 1083: EX1083 Petitioner Exhibit 1084: EX1084 Petitioner Exhibit 1085: EX1085 Petitioner Exhibit 1086: EX1086 Petitioner Exhibit 1087: EX1087
7/30/2024	07-30-2024-Petitioner	Petitioner Opposition 24: Petitioner's Response to Patent Owner's Motion to Terminate Proceedings
7/16/2024	07-16-2024-Patent_Owner	Patent Owner Motion: Other 23: Patent Owner's Motion to Terminate Proceedings Patent Owner Exhibit 2023: EX2023 - Excerpt of 10x Genomics, Inc. v. Parse Biosciences, Inc., No. 22-1117-JHS, D.I. 001 (D. Del. Aug. 24, 2022) (Complaint) Patent Owner Exhibit 2024: EX2024 - Excerpt of Parse Biosciences, Inc. v. 10x Genomics, Inc. IPR2023-00878, Pap.1 (Apr. 20, 2023) Patent Owner Exhibit 2025: EX2025 - Excerpt of Parse Biosciences, Inc. v. 10x Genomics, Inc. IPR2023-00958, Pap.1 (May 25, 2023) Patent Owner Exhibit 2026: EX2026 - Excerpt of Parse Biosciences, Inc. v. 10x Genomics, Inc. IPR2023-01030, Pap.1 (June 06, 2023) Patent Owner Exhibit 2027: EX2027 - Excerpt of Parse Biosciences, Inc. v. 10x Genomics, Inc. IPR2023-01033, Pap.1 (June 06, 2023) Patent Owner Exhibit 2030: EX2030 - 10x Genomics, Inc. et al. v. Parse Biosciences, Inc., No. 22-1117-JHS, D.I. 121 (D. Del. Dec. 21, 2023) (Order Denying Motion to Stay) Patent Owner Exhibit 2031: EX2031 - Excerpt of Parse Biosciences, Inc. v. 10x Genomics, Inc. IPR2023-00958, Pap.8 (Jan. 05, 2024) (Rehearing Request) Patent Owner Exhibit 2032: EX2032 - 10x Genomics, Inc. v. Parse Biosciences, Inc., No. 22-1117-JHS, D.I. 048 (D. Del. Mar. 07, 2023) (Scheduling Order) Patent Owner Exhibit 2034: EX2034 - 10x Genomics, Inc. v. Parse Biosciences, Inc., No. 22-1117-JHS, D.I. 164 (D. Del. Feb. 20, 2024) (Order Denying Parse Renewed Motion to Stay) Patent Owner Exhibit 2035: EX2035 - Excerpt of 10x Genomics, Inc. v. Parse Biosciences, Inc., No. 22-1117-JHS, D.I. 229 (D. Del. June 12, 2024) (Parse’s Op-position to 10x Ltr. re Motion to Strike Portions of Cooper Re-port; Ex. A: Sept. 19, 2023 Parse First Amended Invalidity Con-tention; Ex. B: Apr. 16, 2024 Parse Second Amended Invalidity Contention) Patent Owner Exhibit 2036: EX2036 - Excerpt of 10x Genomics, Inc. v. Parse Biosciences, Inc., No. 22-1117-JHS, D.I. 218 (D. Del. May 30) (10x Ltr. re Motion to Strike Portions of Cooper Report; Ex. A: May 17, 2024 Expert Report of Dr. Gregory Cooper Regarding Invalidity (Excerpted)) Patent Owner Exhibit 2037: EX2037 - 10x Genomics, Inc. v. Parse Biosciences, Inc., No. 22-1117-JHS, May 21, 2024 Email from J. Reich to D. Walter re Cooper Report Patent Owner Exhibit 2038: EX2038 - 10x Genomics, Inc. v. Parse Biosciences, Inc., No. 22-1117-JHS, May 28, 2024 Email from D. Walter to J. Reich re Cooper Report Patent Owner Exhibit 2039: EX2039 - 10x Genomics, Inc. v. Parse Biosciences, Inc., No. 22-1117-JHS, D.I. 224 (D. Del. June 06, 2024) (Parse Ltr. Requesting New Trial Date)
7/3/2024	07-03-2024-Board	Board Order: Other 22: Order Conduct of the Proceeding Board Exhibit 3001: Email
7/3/2024	07-03-2024-Petitioner	Petitioner Other: other 21: Record of Oral Teleconference Held on July 2, 2024
6/21/2024	06-21-2024-Petitioner	Petitioner Notice: Notice of deposition 20: Petitioner Parse Biosciences, Inc.'s Notice of John QuackenbushDeposition of
5/22/2024	05-22-2024-Petitioner	Petitioner Exhibit 1067: EX1067
5/3/2024	05-03-2024-Patent_Owner	Patent Owner PO Response to Pet 19: Patent Owner's Response Patent Owner Exhibit 2011: EX2011 - Declaration of Sayem Osman Patent Owner Exhibit 2012: EX2012 - Parse Biosciences, Inc. v. 10x Genomics, Inc. IPR2023-00876, EX1002 (Apr. 20, 2023) (Declaration of Gregory Cooper, Ph.D.) Patent Owner Exhibit 2013: EX2013 - Declaration of Dr. John Quackenbush Patent Owner Exhibit 2014: EX2014 - Bruce Alberts, et al., Molecular Biology of the Cell, Garland Science (4th ed. 2002) Patent Owner Exhibit 2015: EX2015 - S. Guan, A. Blanchard, P. Zhang, & Z. Zhu, Alteration of Sequence Specificity of the Type IIS Restriction Endonuclease BtsI, (July 26, 2010) Patent Owner Exhibit 2016: EX2016 - Piovesan et al., On the length, weight, and GT content of the human genome, BMC Res. Notes 12:106 (2019) Patent Owner Exhibit 2017: EX2017 - T. Chauhan, T4 DNA Ligase: Introduction, Functions, Applications, and Protocol Patent Owner Exhibit 2018: EX2018 - IPR2023-00876 Deposition Transcript of Gregory Cooper, Ph.D. Patent Owner Exhibit 2019: EX2019 - Li et al., Amplification and analysis of DNA sequences in single human sperm and diploid cells, Nature 335(6189):414-417 (1998) Patent Owner Exhibit 2020: EX2020 - IPR2023-00955 Deposition Transcript of Gregory Cooper, Ph.D.
4/17/2024	04-17-2024-Patent_Owner	Patent Owner Other: other 18: April 17, 2024 Joint Stipulation to Modify Due Dates 1, 2, and 3
4/1/2024	04-01-2024-Patent_Owner	Patent Owner Notice: Notice of deposition 17: Deposition Notice of Gregory Cooper, Ph.D.
2/23/2024	02-23-2024-Board	Board Order: on Motion 16: ORDER Granting Petitioner’s Motions for Pro Hac Vice Admission of Edward R. Reines 37 C.F.R. § 42.10
2/16/2024	02-16-2024-Petitioner	Petitioner Notice: Updated Mandatory Notice 12: Petitioner Parse Biosciences, Inc.'s Supplemental Mandatory Notice Adding Backup Counsel Under 37 C.F.R. Section 42.8(a)(3) Petitioner Notice: Power of Attorney 13: Petitioner Parse Biosciences, Inc.'s Supplemental Power of Attorney for Edward R. Reines Petitioner Motion: PHV 14: Petitioner Parse Biosciences, Inc.'s Motion for Admission Pro Hac Vice of Edward R. Reines Pursuant to 37 C.F.R. Section 42.10 Petitioner Notice: Exhibit list 15: Petitioner Parse Biosciences, Inc.'s Updated Exhibit List Petitioner Exhibit 1064: Exhibit 1064 - Declaration of Edward R. Reines in support of pro hac vice motion Petitioner Exhibit 1065: Exhibit 1065 - In re Reines Federal Circuit decision, 14-MA0004 Petitioner Exhibit 1066: Exhibit 1066 - Personal Statement of Edward R. Reines, Fed. Cir. 14-MA004
2/15/2024	02-15-2024-Patent_Owner	Patent Owner Other: other 11: Patent Owner's Objections to Evidence
2/5/2024	02-05-2024-Board	Event: Petition Institution (Granted) Board Institution Decision: granting institution on request for rehearing 9: Institution Decision: granting institution on request for rehearing Board Order: Other 10: SCHEDULING ORDER
1/2/2024	01-02-2024-Petitioner	Petitioner Rehearing request: Institution 8: Petitioner's Rehearing Request of the Board's Non-Institution Decision Petitioner Exhibit 1063: EX1063
12/18/2023	12-18-2023-Board	Event: Petition Institution (Denied) Board Institution Decision: Deny 7: Denying Institution of Inter Partes Review 35 U.S.C. § 314
9/21/2023	09-21-2023-Patent_Owner	Event: Preliminary Response Patent Owner POPR: filed 6: Patent Owner's Preliminary Response Patent Owner Exhibit 2001: EX2001 - File History of U.S. App. No. 15/677,957 Patent Owner Exhibit 2002: EX2002 - File History of U.S. App. No. 13/859,450 Patent Owner Exhibit 2003: EX2003 - Dictionary of Microbiology and Molecular Biology (2d ed. 1987) Patent Owner Exhibit 2004: EX2004 [PART 1] - File History of U.S. App. No. 14/792,094 Patent Owner Exhibit 2004: EX2004 [PART 2] - File History of U.S. App. No. 14/792,094 Patent Owner Exhibit 2005: EX2005 - File History of U.S. App. No. 13/387,343 Patent Owner Exhibit 2006: EX2006 - U.S. Patent Pub. No. 2007/0238113 Patent Owner Exhibit 2007: EX2007 - Laird et al., Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules, 101 PNAS 204-09 (Dec. 12, 2003) Patent Owner Exhibit 2008: EX2008 - Parse Biosciences, Inc. v. 10x, Genomics Inc., IPR2023-00876, Pap.1 (April 20, 2023) Patent Owner Exhibit 2009: EX2009 - File History of U.S. App. No. 14/172,694 Patent Owner Exhibit 2010: EX2010 - Declaration of Sayem Osman
6/21/2023	06-21-2023-Board	Board Notice: Notice filing date accorded 5: Notice: Notice filing date accorded
6/15/2023	06-15-2023-Patent_Owner	Patent Owner Notice: Power of Attorney 3: Patent Owner's Power of Attorney & Designation of Lead and Back-Up Counsel Patent Owner Notice: Mandatory Notice 4: Patent Owner's Mandatory Notices
5/25/2023	05-25-2023-Petitioner	Petitioner Petition: as filed 1: Petition for Inter Partes Review of U.S. Patent No. 10,240,197 Petitioner Notice: Power of Attorney 2: Notice : Parse Biosciences, Inc. Power of Attorney Petitioner Exhibit 1001: U.S. Patent No. 10,240,197 Petitioner Exhibit 1002: Declaration of Gregory Cooper, Ph.D. Petitioner Exhibit 1003: PCT Patent Publication No. WO 2010/117620 ("Linnarsson") Petitioner Exhibit 1004: Megan L McCloskey et al., Encoding PCR Products ("McCloskey") Petitioner Exhibit 1005: Prosecution File History of U.S. Patent No. 10,240,197 Petitioner Exhibit 1006: Leslie H. Brail et al., Gene expression in individual cells ("Brail") Petitioner Exhibit 1007: Hubert Hug et al., Measurement of Number of Molecules ("Hug") Petitioner Exhibit 1009: Gerald Schochetman et al., Polymerase Chain Reaction ("Schochetman") Petitioner Exhibit 1011: H.C. Yang et al., A genome-wide study of preferential ("Yang") Petitioner Exhibit 1012: Severine A Degrelle et al., Amplification biases ("Degrelle") Petitioner Exhibit 1013: Brooks E. Miner et al., Molecular barcodes ("Miner") Petitioner Exhibit 1015: U.S. Patent Provisional Application No. 61/164,759 ("Linnarsson Provisional Petitioner Exhibit 1016: Defendant 10X Genomic's Opening Br ISO Mtn to Dismiss Petitioner Exhibit 1017: Defendant 10X Genomic's Reply Br ISO Mtn to Dismiss Petitioner Exhibit 1018: Scheduling Order, C.A. No. 22-1117-JHS D.Del. Petitioner Exhibit 1019: Federal Judicial Caseload Statistics (2022) Petitioner Exhibit 1020: Curriculum Vitae of Gregory Cooper Petitioner Exhibit 1021: Jonas Binladen et al., The Use of Coded PCR Primers "Binladen" Petitioner Exhibit 1023: Motion Success for Stay Pending IPR In Delaware District Petitioner Exhibit 1024: Hiroto Okayama and Paul Berg, High-Efficiency Cloning ("Okayama") Petitioner Exhibit 1025: Bruce Alberts, et al., Chapter 6 How Cells read the Genome Petitioner Exhibit 1026: Assignment Record for U.S. Patent 8,298,767 Petitioner Exhibit 1027: 10x Genomics Legal Notice Petitioner Exhibit 1028: Declaration of Sylvia D. Hall-Ellis, Ph.D. Petitioner Exhibit 1029: US Patent No. 8,835,358 B2 Petitioner Exhibit 1030: S. Clancy et al., Translation: DNA to mRNA to Protein Petitioner Exhibit 1031: Cole Trapnell, Defining cell types ("Trapnell") Petitioner Exhibit 1032: Gerard Brady et al., Representative in Vitro ("Brady") Petitioner Exhibit 1033: James Eberwine et al., Analysis of gene expression ("Eberwine") Petitioner Exhibit 1034: Maria de Fatima Bonaldo et al., Normalization and Subtraction ("Bonaldo") Petitioner Exhibit 1035: Sydney Brenner et al., In vitro cloning of complex ("Brenner") Petitioner Exhibit 1036: David H. Persing, Polymerase Chain Reaction ("Persing") Petitioner Exhibit 1037: Kazuki Kurimoto et al., An improved single-cell cDNA ("Kurimoto") Petitioner Exhibit 1038: Shigeyuki Esumi et al., Method for single-cell microarray ("Esumi") Petitioner Exhibit 1039: Y. Shibata et al., Cloning Full-length ("Shibata") Petitioner Exhibit 1040: U.S. Patent Application 2004/0166499 Petitioner Exhibit 1041: Athina Gkazi, An Overview of Next-Generation Sequencing Petitioner Exhibit 1042: Rami Sukarieh, Relocalization of elF4E by its binding partners Petitioner Exhibit 1043: Clyde A. Hutchinson, DNA sequencing ("Hutchinson") Petitioner Exhibit 1044: Beata G Vertessy and Judit Toth, Keeping Uracil Out of DNA ("Vertessy") Petitioner Exhibit 1045: Elaine R. Mardis, Next-Generation DNA ("Mardis") Petitioner Exhibit 1046: Jay Shendure and Hanlee Ji, Next-Generation DNA Sequencing Petitioner Exhibit 1047: Elaine R. Mardis, The impact of next-generation sequencing ("Mardis 2") Petitioner Exhibit 1048: Robert A. Holt and Steven J.M. Jones, The new paradigm ("Holt") Petitioner Exhibit 1049: National Human Genome Research Institute, Nucleotide Petitioner Exhibit 1050: National Human Genome Research Institute, Polymerase Chain Reaction Petitioner Exhibit 1051: Becton, Dickinson & Co. & Cellular Research, Inc.'s First Am Complaint Petitioner Exhibit 1052: Exs 26 & 27 attached to Becton, Dickinson & Co. First Am Complaint Petitioner Exhibit 1053: US 9,708,659 B2 Petitioner Exhibit 1054: Georgi K. Marinov et. al, From single-cell ("Marinov") Petitioner Exhibit 1055: United States Patent Application Publication to McCloskey ("McCloskey II") Petitioner Exhibit 1056: Boris Hollas & Rainer Schuler, A Stochastic Approach ("Hollas") Petitioner Exhibit 1057: Thomas J Albert et al., Direct Selection of Human ("Albert") Petitioner Exhibit 1058: US 7,537,897 B2 Petitioner Exhibit 1060: Reinhard Stoger, Epigenetics and Obesity ("Stoger") Petitioner Exhibit 1061: Diane P. Genereux et. al, Errors in the Bisulfite ("Genereux") Petitioner Exhibit 1062: Pierre Nicolas et. al., The Stem Cell Population ("Nicolas")

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Parse Biosciences, Inc. v. 10x Genomics, Inc.

IPR2023-00955 | Patent Trial and Appeal Board

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