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`-1402702452.1590003945)
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`
`By Shawn Bishop
`
`Losing Weight Can Have Big Impact on Those with Diabetes
`
`December 14, 2012
` (https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-weight-
`
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`Diabetes - Mayo Clinic News Network&body=Article: https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-weight-can-
`have-big-impact-on-those-with-diabetes%2F)
`
`Losing Weight Can Have Big Impact on Those with Diabetes
`December 14, 2012
`Dear Mayo Clinic:
`Can type 2 diabetes be cured just by losing weight?
`Answer:
`Losing weight can have a big impact on diabetes. Although it might not cure type 2 diabetes in every case, getting to a healthy body weight
`does have that potential for many people. Even if it doesn't completely cure the disease, losing weight may make it possible for people with
`diabetes to take less medication. It often helps manage or prevent some of the health problems that can come with diabetes, too.
`People who have diabetes have too much sugar in their blood. This happens because of a problem with the hormone called insulin. Insulin is
`made in the pancreas — a gland located just behind the stomach. When you eat, the pancreas releases insulin into your bloodstream. The
`insulin allows sugar to enter your cells, lowering the amount of sugar in your blood.
`If you have type 2 diabetes, the pancreas does not make enough insulin or your body cannot use insulin as well as it should. So sugar cannot
`move into your cells. Instead, it builds up in your blood.
`The reason why type 2 diabetes develops is not completely clear. But being overweight plays a role. In people who are overweight, the body
`sometimes needs as much as two to three times more insulin than it would if it was at a healthy weight. In those who develop diabetes, that
`is more insulin than the pancreas is able to produce.
`When the pancreas tries to make that much insulin, it is pushed beyond its capacity and insulin-producing cells start to die. That makes the
`situation worse because the pancreas then has even fewer cells with which to make insulin. Compounding the problem, research also has
`shown that fat cells of people who are obese and who have more abdominal fat actually release molecules that can be harmful to the
`pancreas. So the more abdominal fat you have, the higher the risk of damage to your pancreas.
`Getting to a lower weight reduces many of these problems. When you weigh less, your pancreas is better able to keep up with your body's
`need for insulin. In some cases, weight loss is enough to restore blood sugar to a normal level, which eliminates diabetes. Even if it doesn't
`get your blood sugar completely back to normal, it may lower your need for insulin therapy or other medications to control diabetes. It also
`lessens your risk for other serious complications of diabetes, including heart problems, kidney disease and nerve damage.
`The benefits of healthy weight as it relates to diabetes continue over time, too. Many people mistakenly believe that a person's risk for
`diabetes automatically goes up with age. In fact, your diabetes risk rises over time only if you gain weight and are less active as you age. For
`those who stay fit, the risk of developing diabetes remains the same or increases only slightly.
`For those with a family history of diabetes, weight control is critical. Research has shown that people who have a family history of type 2
`diabetes are more vulnerable to developing type 2 diabetes themselves. Staying at a healthy weight lowers their chances of getting the
`disease by about 70 to 90 percent.
`In general, healthy weight is defined as a body mass index, or BMI, of 25 or lower. To get there, you don't need to run marathons or do hours
`of workouts each day. But you do need to be active on a regular basis. If you are interested in losing weight, talk to your doctor about an
`exercise and diet program that best fits your needs.
`
`Feedback
`
`Novo Nordisk Exhibit 2383
`Mylan Pharms. Inc. v. Novo Nordisk A/S
`IPR2023-00724
`Page 00001
`
`
`mc_id=us&utm_source=newsnetwork&utm_medium=l&utm_content=appointmentbutton&utm_campaign=mayoclinic&geo=national&placementsite=enterprise&cauid=100722&_ga=2.191197162.1980770420.1605558659
`-1402702452.1590003945)
`
`(https://newsnetwork.mayoclinic.org/)
`
`News Network (/)
`
`By Shawn Bishop
`
`Losing Weight Can Have Big Impact on Those with Diabetes
`
`December 14, 2012
` (https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-weight-
`
`can-have-big-impact-on-those-with-diabetes%2F)
` (https://twitter.com/intent/tweet?
`url=https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-weight-can-have-big-impact-on-those-with-diabetes%2F)
` (https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-
`
`weight-can-have-big-impact-on-those-with-diabetes%2F)
` (mailto:?subject=Losing Weight Can Have Big Impact on Those with
`Diabetes - Mayo Clinic News Network&body=Article: https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-weight-can-
`have-big-impact-on-those-with-diabetes%2F)
`
`Losing Weight Can Have Big Impact on Those with Diabetes
`December 14, 2012
`Dear Mayo Clinic:
`Can type 2 diabetes be cured just by losing weight?
`Answer:
`Losing weight can have a big impact on diabetes. Although it might not cure type 2 diabetes in every case, getting to a healthy body weight
`does have that potential for many people. Even if it doesn't completely cure the disease, losing weight may make it possible for people with
`diabetes to take less medication. It often helps manage or prevent some of the health problems that can come with diabetes, too.
`People who have diabetes have too much sugar in their blood. This happens because of a problem with the hormone called insulin. Insulin is
`made in the pancreas — a gland located just behind the stomach. When you eat, the pancreas releases insulin into your bloodstream. The
`insulin allows sugar to enter your cells, lowering the amount of sugar in your blood.
`If you have type 2 diabetes, the pancreas does not make enough insulin or your body cannot use insulin as well as it should. So sugar cannot
`move into your cells. Instead, it builds up in your blood.
`The reason why type 2 diabetes develops is not completely clear. But being overweight plays a role. In people who are overweight, the body
`sometimes needs as much as two to three times more insulin than it would if it was at a healthy weight. In those who develop diabetes, that
`is more insulin than the pancreas is able to produce.
`When the pancreas tries to make that much insulin, it is pushed beyond its capacity and insulin-producing cells start to die. That makes the
`situation worse because the pancreas then has even fewer cells with which to make insulin. Compounding the problem, research also has
`shown that fat cells of people who are obese and who have more abdominal fat actually release molecules that can be harmful to the
`pancreas. So the more abdominal fat you have, the higher the risk of damage to your pancreas.
`Getting to a lower weight reduces many of these problems. When you weigh less, your pancreas is better able to keep up with your body's
`need for insulin. In some cases, weight loss is enough to restore blood sugar to a normal level, which eliminates diabetes. Even if it doesn't
`get your blood sugar completely back to normal, it may lower your need for insulin therapy or other medications to control diabetes. It also
`lessens your risk for other serious complications of diabetes, including heart problems, kidney disease and nerve damage.
`The benefits of healthy weight as it relates to diabetes continue over time, too. Many people mistakenly believe that a person's risk for
`diabetes automatically goes up with age. In fact, your diabetes risk rises over time only if you gain weight and are less active as you age. For
`those who stay fit, the risk of developing diabetes remains the same or increases only slightly.
`For those with a family history of diabetes, weight control is critical. Research has shown that people who have a family history of type 2
`diabetes are more vulnerable to developing type 2 diabetes themselves. Staying at a healthy weight lowers their chances of getting the
`disease by about 70 to 90 percent.
`In general, healthy weight is defined as a body mass index, or BMI, of 25 or lower. To get there, you don't need to run marathons or do hours
`of workouts each day. But you do need to be active on a regular basis. If you are interested in losing weight, talk to your doctor about an
`exercise and diet program that best fits your needs.
`
`Feedback
`
`Novo Nordisk Exhibit 2383
`Mylan Pharms. Inc. v. Novo Nordisk A/S
`IPR2023-00724
`Page 00001
`
`
`
`— Robert Rizza, M.D., and Michael Jensen, M.D., Endocrinology, Mayo Clinic, Rochester, Minn.
`
` (https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-weight-
`
` (https://twitter.com/intent/tweet?
`can-have-big-impact-on-those-with-diabetes%2F)
`url=https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-weight-can-have-big-impact-on-those-with-diabetes%2F)
` (https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-
`
` (mailto:?subject=Losing Weight Can Have Big Impact on Those with
`weight-can-have-big-impact-on-those-with-diabetes%2F)
`Diabetes - Mayo Clinic News Network&body=Article: https%3A%2F%2Fnewsnetwork.mayoclinic.org%2Fdiscussion%2Flosing-weight-can-
`have-big-impact-on-those-with-diabetes%2F)
`
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`
`(htt
`ps:/
`/ne
`wsn
`etw
`ork.
`may
`ocli
`nic.
`org/
`disc
`ussi
`on/
`sch
`ool-
`sho
`otin
`g-
`trag
`edy
`-
`grip
`s-
`the-
`cou
`ntry
`/)
`
`Feedback
`
`Novo Nordisk Exhibit 2383
`Mylan Pharms. Inc. v. Novo Nordisk A/S
`IPR2023-00724
`Page 00002
`
`
`
`Unlocking the mechanisms of HIV in preclinical research
`(https://newsnetwork.mayoclinic.org/discussion/unlocking-the-mechanisms-of-hiv-in-preclinical-research/)
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`Novo Nordisk Exhibit 2383
`Mylan Pharms. Inc. v. Novo Nordisk A/S
`IPR2023-00724
`Page 00003
`
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