Supplementary Appendix
`
`This appendix has been provided by the authors to give readers additional information about their work.
`
`Supplement to: Marso SP, Bain SC, Consoli A, et al. Semaglutide and cardiovascular outcomes in patients with
`type 2 diabetes. N Engl J Med 2016;375:1834-44. DOI: 10.1056/NEJMoa1607141
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`SUSTAIN 6 – Summary of figures / tables included in the supplement
`
`Table of Contents
`
`Supplementary Appendix
`
`SUSTAIN 6 Committee Members and Investigators
`
`Additional statistical details
`
`Figure S1A.
`
`Patient disposition
`
`Figure S1B.
`
`Reasons for patients being excluded or leaving trial before
`randomization
`
`Figure S2.
`
`Forest plot showing sensitivity analyses for the primary
`outcome
`
`Figure S3.
`
`Forest plot showing subgroup analyses for the primary outcome
`
`Figure S4.
`
`Cardiovascular outcomes by individual treatment group
`
`
`Figure S5.
`
`Microvascular outcomes
`
`Figure S6.
`
`Figure S7.
`
`Figure S8.
`(cid:3)Table S1.
`
`(cid:3)Table S2.
`(cid:3)Table S3.
`
`(cid:3)Table S4.
`(cid:3)Table S5.
`(cid:3)Table S6.
`(cid:3)Table S7A.
`
`(cid:3)Table S7B.
`(cid:3)Table S8A.
`(cid:3)Table S8B.
`
`(cid:3)
`
`Mean change in systolic (Panel A) and diastolic (Panel B) blood
`pressure over time
`
`Mean change in lipase (Panel A) and amylase (Panel B) over
`time
`
`Neoplasms: Total and malignant by organ of origin
`
`Eligible patients: Criteria for clinical and subclinical
`cardiovascular disease
`
`List of inclusion and exclusion criteria
`
`Glycemic control in SUSTAIN 6
`(cid:120)(cid:3) Actions taken to ensure optimal glycemic control in
`SUSTAIN 6
`
`Clinical event definitions for all adjudicated outcomes
`
`Premature treatment discontinuation
`
`Baseline characteristics (expanded)
`
`Antihyperglycemic medication at baseline
`
`Introduction of antihyperglycemic medication during the trial
`
`Cardiovascular medication at baseline
`
`Introduction of cardiovascular medication during the trial
`
`1(cid:3)
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`
`3
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`26
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`35
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`36
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`39
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`41
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`43
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`47
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`49
`
`51
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`54
`
`55
`
`57
`
`60
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`62
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`78
`
`80
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`85
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`87
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`89
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`92
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`(cid:3)Table S9.
`
`(cid:3)Table S10.
`
`Primary and secondary cardiovascular and microvascular
`outcomes (expanded)
`
`Change from baseline at Week 104 for glycated hemoglobin,
`body weight, blood pressure and pulse, and ratio to baseline at
`Week 104 for lipids
`
`(cid:3)Table S11.
`
`Serious adverse events by system organ class
`
`96
`
`101
`
`105
`
`(cid:3)
`
`2(cid:3)
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`(cid:3) (cid:3)
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`SUSTAIN 6 Committee Members and Investigators
`
`(cid:3) D
`
`ata Monitoring Committee:
`
`Chair: David Fitchett, St Michael’s Hospital, Toronto, Canada
`
`Judith D. Bebchuk, Kaiser Permanente, Pasadena, CA, USA; Nicholas Boon, Royal Infirmary
`of Edinburgh, Edinburgh, UK; David Fitchett, St Michael’s Hospital, Toronto, Canada;
`Timothy Gardner, Dartmouth-Hitchcock Medical Center, Lebanon, PA, USA; Silvio Inzucchi,
`Yale University School of Medicine, USA, New Haven, CT, USA
`
`Event Adjudication Committees
`
`Chair: Bernard R. Chaitman, Saint Louis University Core ECG Laboratory, St. Louis, USA
`
`Cardiology: Richard Bach, Washington University School of Medicine, St. Louis, MO, USA;
`Bernard R. Chaitman, Saint Louis University Core ECG Laboratory, St. Louis, MO, USA;
`Gilbert Gosselin, Montreal Heart Institute, Montreal, Canada; Abhay A. Laddu, Saint Louis
`University School of Medicine, St. Louis, USA
`
`Endocrinology: Stewart G. Albert, Saint Louis University School of Medicine, St. Louis, MO,
`USA
`
`Gastroenterology: C. Prakash Gyawali Washington University School of Medicine, St.
`Louis, MO, USA; Daniel Kast Mullady, Washington University School of Medicine, St. Louis,
`MO, USA
`
`Nephrology: Geoffrey Block, University of Colorado Health Sciences Center, Denver, CO,
`USA; David Bushinsky, University of Rochester Medical Center, Rochester, NY, USA; Kevin
`Martin, Saint Louis University School of Medicine, St. Louis, MO, USA
`
`Neurology: Amer Alsheklhee, Saint Louis University School of Medicine, St. Louis, MO,
`USA; Salvador Cruz-Flores, Texas Tech University Health Sciences Center at El Paso, El
`Paso, TX, USA; Eli S. Feen, Saint Louis University School of Medicine, St. Louis, MO, USA
`
`Oncology: Meagan A. Jacoby, Washington University School of Medicine, St. Louis, MO,
`USA; Joel Picus, Washington University School of Medicine, St. Louis, MO, USA; Mark A.
`Schroeder, Washington University School of Medicine, St. Louis, MO, USA
`
`Ophthalmology: Levent Akduman, Saint Louis University, St. Louis, MO, USA; B. Wayne
`Dudney, Retina Associates of St. Louis, Florissant, MO, USA
`
`
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`Study Investigators
`
`
`
`Algeria: Kahina Aberkane, Salah Mansour, Tizi Ouzou; Malika Bachaoui, 1st November 1954
`Hospital, Oran; Leila Nadia Benali, 1st November 1954 Hospital, Oran; Abdelaziz Berra,
`CHU de Setif, Setif; Yachar Bouacha, Ibn Sina Hospital, Annaba; Nadia Bouziani, 1st
`November 1954 Hospital, Oran; Takait Essalem Charef, CHU de Setif, Setif; Saadia Dahliz,
`Salah Mansour, Tizi Ouzou; Malika Far, Ibn Siba Hospital, Annaba; Samia Griene, Ibn Siba
`Hospital, Annaba; Mahdi Guessas, CHU de Setif, Setif; Nour El Houda Guettaf, CHU de Setif,
`Setif; Fatma Zohra Hachelaf, Ibn Sina Hospital, Annaba; Souad Ibtissam Hannane, 1st
`November 1954 Hospital, Oran; Zohra Lakabi, Salah Mansour, Tizi Ouzou; Abdellah Salah
`Mansour, Salah Mansour, Tizi Ouzou; Hayet Merabet, Salah Mansour, Tizi Ouzou; Amel
`Moussaoui, Ibn Sina Hospital, Annaba; Abdelmalek Nechadi, CHU de Setif, Setif; Said
`Ouardane, Salah Mansour, Tizi Ouzou; Amine Rahou, 1st November 1954 Hospital, Oran.
`
`
`
`Argentina: Guillermo Bianchi, Hospital Sirio Libanes, Ciudad Autonoma de Buenos Aires;
`Gabriela Caeiro, Centro Diabetologico Cordoba Dr. Waitman, Cordoba; Martha Calveyra,
`Medical Center of Diabetes and Nutrition, Ciudad Autonoma de Buenos Aires; Horacio
`Cestari, Sanatorio Güemes, Ciudad Autonoma de Buenos Aires; Natalia Cluigt, Instituto de
`Investigaciones Clinicas, Mar del Plata; Elisa Diaz, Sanatorio Güemes, Ciudad Autonoma de
`Buenos Aires; Débora Ferrari, Hospital Sirio Libanes, Ciudad Autonoma de Buenos Aires;
`Hernan Finkelstein, Sanatorio Güemes, Ciudad Autonoma de Buenos Aires; Gustavo
`Frechtel, Hospital Sirio Libanes, Ciudad Autonoma de Buenos Aires; Graciela Galeano,
`Consultorio Integral de Atención al Diabético, Morón; Laura Garate, Fundacion Favaloro,
`Ciudad Autonoma de Buenos Aires; Veronica Geronazzo, Medical Center of Diabetes and
`Nutrition, Ciudad Autonoma de Buenos Aires; G Gili, Consultorio Integral de Atención al
`Diabético, Morón; Cecilia Heredia, Consultorio Integral de Atención al Diabético, Morón;
`Sonia Hermida, Consultorio Integral de Atención al Diabético, Morón; Claudia Issa,
`Sanatorio Güemes, Ciudad Autonoma de Buenos Aires; Stella Lapolla, Medical Center of
`Diabetes and Nutrition, Ciudad Autonoma de Buenos Aires; Silvia Lovecchio, Hospital Sirio
`Libanes, Ciudad Autonoma de Buenos Aires; María Lozano, Centro Diabetologico Cordoba
`Dr. Waitman, Cordoba; Alfredo Marianacci, Consultorio Integral de Atención al Diabético,
`Morón; Pablo Martinez, Instituto de Investigaciones Clinicas, Mar del Plata; Juan Moukarzel,
`Fundacion Favaloro, Ciudad Autonoma de Buenos Aires; Clara Muller, Hospital Sirio Libanes,
`Ciudad Autonoma de Buenos Aires; Constanza Olivera, Hospital Sirio Libanes, Ciudad
`Autonoma de Buenos Aires; Alejandra Oviedo, Medical Center of Diabetes and Nutrition,
`Ciudad Autonoma de Buenos Aires; Eduardo Parysow, Sanatorio Güemes, Ciudad Autonoma
`de Buenos Aires; F Ponce, Sanatorio Güemes, Ciudad Autonoma de Buenos Aires; Jose
`Pozzi, Centro Diabetologico Cordoba Dr. Waitman, Cordoba; Edgardo Ridner, Hospital Sirio
`Libanes, Ciudad Autonoma de Buenos Aires; Hugo Sanabria, Fundacion Favaloro, Ciudad
`Autonoma de Buenos Aires; Virginia Sernia, Instituto de Investigaciones Clinicas, Mar del
`Plata; Silvana Solis, Centro Diabetologico Cordoba Dr. Waitman, Cordoba; Georgina
`Sposetti, Instituto de Investigaciones Clinicas, Mar del Plata; Patricia Varela, Instituto de
`Investigaciones Clinicas, Mar del Plata; Virginia Visco, Consultorio Integral de Atención al
`
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`Diabético, Morón; Virginia Visco, Medical Center of Diabetes and Nutrition, Ciudad
`Autonoma de Buenos Aires; Jorge Waitman, Centro Diabetologico Cordoba Dr. Waitman,
`Cordoba; Silvana Yohena, Hospital Sirio Libanes, Ciudad Autonoma de Buenos Aires.
`
`
`
`Australia: Jenny Bennett, Box Hill Specialist Consulting rooms, Box Hill, VIC; Tim Davis,
`Fremantle Hospital, Fremantle, WA; Su Ann Ding, Blacktown Hospital, Blacktown, NSW;
`Gregory Fulcher, Royal North Shore Hospital, St Leonards, NSW; Christopher Gilfillan, Box
`Hill Specialist Consulting rooms, Box Hill, VIC; Jui Ho, SAn Endocrine Research, Keswick,
`SA; Samantha Hocking, Royal North Shore Hospital, St Leonards, NSW; Sue-Lynn Lau,
`Blacktown Hospital, Blacktown, NSW; Melissa Lee, St Vincent's Hospital, Fitzroy, VIC; Jaime
`Lin, Blacktown Hospital, Blacktown, NSW; Katherine Lynch, Ipswich Hospital, Ipswich, QLD;
`Richard MacIsaac, St Vincent's Hospital, Fitzroy, VIC; Ashley Makepeace, Fremantle
`Hospital, Fremantle, WA; Mark McLean, Blacktown Hospital, Blacktown, NSW; Negar
`Naderpoor, Repatriation General Hospital, Daw Park, SA; Thomas Nathow, Ipswich Hospital,
`Ipswich, QLD; Anjana Radhakutty, Repatriation General Hospital, Daw Park, SA; Evelyn
`Rank, Ipswich Hospital, Ipswich, QLD; Kannan Reddy, Blacktown Hospital, Blacktown, NSW;
`Anthony Roberts, SAn Endocrine Research, Keswick, SA; Nirupa Sachithanandan, St
`Vincent's Hospital, Fitzroy, VIC; Richard Simpson, Box Hill Specialist Consulting rooms, Box
`Hill, VIC; Stephen Stranks, Repatriation General Hospital, Daw Park, SA; Jessie Teng, St
`Vincent's Hospital, Fitzroy, VIC; Glenn Ward, St Vincent's Hospital, Fitzroy, VIC; Jane
`Zhang, Blacktown Hospital, Blacktown, NSW.
`
`
`
`Brazil: Gustavo Akerman, CPQuali Pesquisa Clínica Ltda, São Paulo, SP; Erica Alves, Centro
`de Pesquisas Clínicas, São Paulo, SP; Breno Alves, Disciplina de Endocrinologia, Hospital das
`Clínicas de São Paulo, São Paulo, SP; Jacy Alves, Hospital de Clínicas da Universidade
`Federal do Paraná, Curitiba, PR; Pierro Berlinger, Pontifical Catholic University of Campinas,
`Hospital e Maternidade Ceiso, Campinas, SP; Anke de Bem, Hospital de Clínicas da
`Universidade Federal do Paraná, Curitiba PR; Renata Bona, Centro de Pesquisas Clínicas,
`São Paulo, SP, Luis Canani, Centro de Pesquisas em Diabetes Ltda, Porto Alegre, RS; Ana
`Carolina, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará,
`Belém, PR; Denise Castro, Centro de Pesquisas Clínicas, São Paulo, SP; Cintia Cercato,
`Disciplina de Endocrinologia, Hospital das Clínicas de São Paulo, São Paulo, SP; Cintia
`Cercato, Disciplina de Endocrinologia, Hospital das Clínicas de São Paulo,São Paulo, SP;
`Midiã Costa, Pontifical Catholic University of Campinas, Hospital e Maternidade Ceiso,
`Campinas, SP; Freddy Eliaschewitz, Centro de Pesquisas Clínicas, São Paulo, SP; João
`Felício, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém,
`PR; Denise Franco, Centro de Pesquisas Clínicas, São Paulo, SP; Paulo Genestreti, Centro de
`Pesquisas Clínicas, São Paulo, SP; Rodrigo Gonçalves, Centro de Pesquisas Clínicas, São
`Paulo, SP; Michele Grossman, Centro de Pesquisas Clínicas, São Paulo, SP; Jorge Gross,
`Centro de Pesquisas em Diabetes Ltda., Porto Alegre, RS; Cláudia Guimarães, CPQuali
`Pesquisa Clínica Ltda, São Paulo, SP; Thaisa Jonasson, Hospital de Clínicas da Universidade
`Federal do Paraná, Curitiba, PR; Fernanda Justus, Hospital de Clínicas da Universidade
`Federal do Paraná, Curitiba, PR; Suzanny Ladeira, Hospital Universitário João de Barros
`Barreto, Universidade Federal do Pará, Belém, PR; Franciane Melo, Hospital Universitário
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`João de Barros Barreto, Universidade Federal do Pará, Belém, PR; Karem Miléo, Hospital
`Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PR; Margareth
`Miyahara, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará,
`Belém, PR; Lidiane Perlamagna, Centro de Pesquisas Clínicas, São Paulo, SP; Rosangela
`Rea, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR; Celia Regina,
`Centro de Pesquisas Clínicas, São Paulo, SP; Sylka Rodovalho, Pontifical Catholic University
`of Campinas, Hospital e Maternidade Ceiso, Campinas, SP; Augusto Santomauro, CPQuali
`Pesquisa Clínica Ltda, São Paulo, SP; José Saraiva, Pontifical Catholic University of
`Campinas, Hospital e Maternidade Ceiso, Campinas, SP; Carla Sartori, Centro de Pesquisas
`em Diabetes Ltda, Porto Alegre, RS; Flávia Silvia, Pontifical Catholic University of Campinas,
`Hospital e Maternidade Ceiso, Campinas, SP; Kátia Siqueira, Centro de Pesquisas Clínicas,
`São Paulo, SP; Luiz Turatti, CPQuali Pesquisa Clínica Ltda, São Paulo, SP; Marcelo Uehara,
`Centro de Diabetes e Obesidade, Hospital do Rim e Hipertensão, São Paulo, SP; Adriana
`Valenti, Centro de Pesquisas em Diabetes Ltda, Porto Alegre, RS; Guilherme Visconti,
`Centro de Pesquisas Clínicas, São Paulo, SP; Leila Zanatta, Hospital de Clínicas da
`Universidade Federal do Paraná, Curitiba, PR; Maria Teresa Zanella, Centro de Diabetes e
`Obesidade, Hospital do Rim e Hipertensão, São Paulo, SP.
`
`
`
`Bulgaria: Zhivka Asyova, Medical Institute of Ministry of interior, Sofia; Mila Boyadzhieva,
`MHAT Sveta Marina, Varna; Ivona Daskalova, MMA-MHAT Sofia, Clinic of Endocrinology and
`Metabolic Diseases, Sofia; Silviya Ganeva-Todorova, UMHAT Dr. Georgi Stranski, Pleven;
`Kiril Hristozov, MHAT Sveta Marina, Varna; Galina Kibarova, Medical Institute of Ministry of
`interior, Sofia; Veselin Kokareshkov, UMHAT Dr. Georgi Stranski, Pleven; Galina Kolcheva,
`Medical Institute of Ministry of interior, Sofia; Ivaylo Lefterov, DCC XII-Sofia EOOD,
`Endocrinology Consulting Room, Sofia; Nadezhda Popova, Medical Institute of Ministry of
`interior, Sofia; Katya Todorova, UMHAT Dr. Georgi Stranski, Pleven; Antoaneta Toneva,
`UMHAT Dr. Georgi Stranski, Pleven; Tzvetelina Totomirova, MMA-MHAT Sofia, Clinic of
`Endocrinology and Metabolic Diseases, Sofia; Boyana Trifonova, MHAT Sveta Marina, Varna;
`Natalia Veleva, DCC XII-Sofia EOOD, Endocrinology Consulting Room, Sofia.
`
`
`
`Canada: Andrew Advani, St. Michael's Hospital, Toronto, Ontario; Simona Burs, C-endo
`Diabetes and Endocrinology Clinic, Calgary, Ontario; Sylvain Chouinard, Institut
`Universitaire de Cardiologie et de Pneum. de Quebec, Quebec, Ontario; Mei Chu, C-endo
`Diabetes and Endocrinology Clinic, Calgary, Ontario; James Conway, Canadian Centre for
`Research on Diabetes, Smiths Falls, Quebec; Francois Dube, Institut Universitaire de
`Cardiologie et de Pneum. de Quebec, Quebec, Quebec; Fadia El Boreky, Sameh Fikry
`Medicine Professional Corporation, Waterloo, Manitoba; Sameh Fikry, Sameh Fikry Medicine
`Professional Corporation, Waterloo, Manitoba; Claude Garceau, Institut Universitaire de
`Cardiologie et de Pneum. de Quebec, Quebec, Ontario; Benoit Gervais, Rhodin Recherche
`Clinique, Drummondville, Ontario; Mahua Ghosh, University of Alberta, Edmonton, Alberta;
`Jean-Marc Girard, Medexa Recherche, Victoriaville, Alberta; Amir Hanna, St. Michael's
`Hospital, Toronto, Alberta; Thomasz Hruczkowski, University of Alberta, Edmonton,Alberta;
`Carmen Hurd, Winnipeg Regional Health Authority, Winnipeg, Alberta; Robert Josse, St.
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`Michael's Hospital, Toronto, Alberta; Tisha Joy, St. Joseph's Health Care, London, Ontario;
`Marcel Jutras, Rhodin Recherche Clinique, Drummondville, Ontario; Munish Khosla, C-endo
`Diabetes and Endocrinology Clinic, Calgary, Quebec; Isabelle Kirouac, Institut Universitaire
`de Cardiologie et de Pneum. de Quebec, Quebec, Quebec; Isabelle Labonte, Institut
`Universitaire de Cardiologie et de Pneum. de Quebec, Quebec, Quebec; Lawrence A. Leiter,
`St. Michael's Hospital, Toronto, Quebec; Stephanie Li, University of Alberta, Edmonton,
`Quebec; Joanne Liutkus, Cambridge, Ontario; Irene M. Hramiak, St. Joseph's Health Care,
`London, Ontario; Charlotte McDonald, St. Joseph's Health Care, London, Ontario; Alykhan
`Nanji, C-endo Diabetes and Endocrinology Clinic, Calgary, Ontario; Raj Padwal, University of
`Alberta, Edmonton, Ontario; Beata Patasi, Canadian Centre for Research on Diabetes Smiths
`Falls, Quebec; Terri Paul, St. Joseph's Health Care, London, Quebec; Sue Pedersen, C-endo
`Diabetes and Endocrinology Clinic, Calgary, Alberta; Kathleen Raby, Institut Universitaire de
`Cardiologie et de Pneum. de Quebec, Quebec, Alberta; Alan Rosenbloom, Scisco Clinical
`Research, Cornwall, Alberta; Lorne Scharf, Scisco Clinical Research, Cornwall, Alberta; Peter
`Senior, University of Alberta, Edmonton, Alberta; Roya Shaikholeslami, Cambridge, Ontario;
`Chandrasekaran Sivakumar, C-endo Diabetes and Endocrinology Clinic, Calgary, Ontario;
`Anca Tapardel, University of Alberta, Edmonton, Ontario; Guy Theriault, Medexa Recherche,
`Victoriaville, Quebec; George Tsoukas, Applied Medical Informatics Research, Westmount,
`Quebec; Michael Tsoukas, Applied Medical Informatics Research, Westmount, Ontario;
`Vincent Woo , Winnipeg Regional Health Authority, Winnipeg, Ontario.
`
`
`
`Denmark: Lise Tarnow, Trine Boesgaard, Martin Ridderstråle, Sidsel Christensen, Thomas
`Dejgaard, Steno Diabetes Center, Gentofte; Søren Gregersen, Aarhus Sygehus THG, Aarhus
`C; Anne Grethe, Schioldan, Aarhus Sygehus THG, Aarhus C; Kjeld Hermansen, Aarhus
`Sygehus THG, Aarhus C; Mette Larsen, Aarhus Sygehus THG, Aarhus C; Filip K. Knop,
`Kristian Mikkelsen, Morten Hansen, Medicinsk afdeling F., Hellerup; Thomas Olesen, Jan Erik
`Henriksen, Lena Snogdal, Endokrinologisk afdeling M, Odense; Sten Madsbad, Ole
`Snorgaard, Dorte Hansen, Endokrinologisk afdeling, Hvidovre Hospital; Tina Vilsbøll,
`Medicinsk afdeling F., Hellerup.
`
`
`
`Germany: Dominik Dahl, Wendisch/Dahl Hamburg, Hamburg; Ulrich Deuse, Esser, Essen;
`Michael Esser, Esser, Essen, Essen; Katharina Gaede, Wendisch/Dahl Hamburg, Hamburg;
`Andreas Hagenow, Zentrum für Klinische Studien Südbrandenburg GmbH, Elsterwerda;
`Adam Kilimnik, Lüdemann, Falkensee; Dirk Lammers, Rose, Münster; Katharina Laubner,
`Universitätsklinikum Freiburg, Freiburg; Hans-Peter Lüdemann, Lüdemann, Falkensee; Jörg
`Lüdemann, Lüdemann, Falkensee, Falkensee; Dirk Mittag, Zentrum für Klinische Studien
`Südbrandenburg GmbH, Elsterwerda; Harald Pohlmeier, Rose, Münster; Ludger Rose, Rose,
`Münster, Münster; Thomas Schaum, RED-Institut für medizinische Studien und Fortbildung
`GmbH, Oldenburg; Jochen Seufert, Universitätsklinikum Freiburg, Freiburg; Julia Thaler,
`RED-Institut für Medizinische Studien und Fortbildung GmbH, Oldenburg; Ulrich Wendisch,
`Wendisch/Dahl Hamburg, Hamburg.
`
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`Israel: Mahmud Abo-Salook, Rabin MC Beilinson Campus Endo, Petah-Tikva; Ibrahim
`Azzam, Institute of Endocrinology, metabolism and hypertension, Tel-Aviv; Yosefa Bar-
`Dayan, Diabetes Clinic Wolfson MC, Holon; Issac Bar-or, Diabetes Clinic Wolfson MC, Holon;
`Amir Bashkin, Institute of Diabetes, Western Galilee MC Nahariya, Nahariya; Amir Bashkin,
`Institute of Diabetes, Western Galilee MC Nahariya, Nahariya; Carlos Benbassat, Rabin MC
`Beilinson Campus Endo, Petah-Tikva; Avivit Cahn, Diabetes Unit Hadasa Ein Karem MC,
`Jerusalem; Lea Chananashvili, Diabetes Clinic Wolfson MC, Holon; Yoav Eizenberg, Rabin
`MC; Beilinson Campus Endo, Petah-Tikva; Dimitry Feldman, Diabetes Clinic Wolfson MC,
`Holon; Svetlana Gershkov, Institute of Diabetes, Western Galilee MC Nahariya, Nahariya;
`Alex Gorshtein, Rabin MC Beilinson Campus Endo, Petah-Tikva; Aaron Halabe, Diabetes
`Clinic Wolfson MC, Holon; Dania Hirsch, Rabin MC Beilinson Campus Endo, Petah-Tikva;
`Israel Hochman, Diabetes Clinic Wolfson MC, Holon; Jacob Ilany, Endrocrinolgy Clinic -
`Sheba Medical Center, Tel Hashomer; Uri Inbal, Endrocrinolgy Clinic - Sheba Medical Center,
`Tel Hashomer; Elena Izkhakov, Institute of Endocrinology, metabolism and hypertension,
`Tel-Aviv; Avraham Karasik, Endrocrinolgy Clinic - Sheba Medical Center, Tel Hashomer;
`Elena Kuyantseva, Institute of Diabetes, Western Galilee MC Nahariya, Nahariya; Irena
`Leibovitch, Diabetes Clinic Wolfson MC, Holon; Gabriella Segal Lieberman, Endrocrinolgy
`Clinic - Sheba Medical Center, Tel Hashomer; Hiba Masri-Iraqi, Rabin MC Beilinson Campus
`Endo, Petah-Tikva; Leonid Michael, Endrocrinolgy Clinic - Sheba Medical Center, Tel
`Hashomer; Ofri Mosenzon, Diabetes Unit Hadasa Ein Karem MC, Jerusalem; Marina
`Nodelman, Institute of Diabetes, Western Galilee MC Nahariya, Nahariya; Ruth Percik,
`Endrocrinolgy Clinic - Sheba Medical Center, Tel Hashomer; Marina Potekhin, Diabetes Unit
`Hadasa Ein Karem MC, Jerusalem; Itamar Raz, Diabetes Unit Hadasa Ein Karem MC,
`Jerusalem; Etal Robenshtok, Rabin MC Beilinson Campus Endo, Petah-Tikva; Merav Serebro,
`Institute of Endocrinology, metabolism and hypertension, Tel-Aviv; Sigal Shaklai, Institute
`of Endocrinology, metabolism and hypertension, Tel-Aviv; Ilan Shimon, Rabin MC Beilinson
`Campus Endo, Petah-Tikva; Daniel Shpitz, Diabetes Clinic Wolfson MC, Holon; Joelle Singer,
`Rabin MC Beilinson Campus Endo, Petah-Tikva; Ilana Slutzky, Rabin MC Beilinson Campus
`Endo, Petah-Tikva; Naftali Stern, Institute of Endocrinology, metabolism and hypertension,
`Tel-Aviv; Yulian Tilis, Diabetes Clinic Wolfson MC, Holon; Amit Tirosh, Rabin MC Beilinson
`Campus Endo, Petah-Tikva; Gloria Tsvetov, Rabin MC Beilinson Campus Endo, Petah-Tikva;
`Ira Vollach, Endrocrinolgy Clinic - Sheba Medical Center, Tel Hashomer; Julio Wainstein,
`Diabetes Clinic Wolfson MC, Holon; Marianna Yaron, Institute of Endocrinology, metabolism
`and hypertension, Tel-Aviv; Elena Zvulunov, Diabetes Clinic Wolfson MC, Holon.
`
`
`
`Italy: Maria Pompea Antonia Baldassarre, Università degli Studi G. D'Annunzio, Chieti Scalo;
`Anna Belligoli, Azienda Ospedaliera di Padova, Padova; Vera Bettini, Azienda Ospedaliera di
`Padova, Padova; Rosamaria Di Biagio, Università degli Studi G. D'Annunzio, Chieti Scalo;
`Silvia Bianchini, Centro Antidiabetico, Bologna; Ilario Carta, ASL no2 Olbia, OLBIA; Elena
`Ceccarelli, Azienda Ospedaliera Universitaria Senese, Siena; Scilla Conci, Azienda
`Ospedaliera di Padova, Padova; Agostino Consoli, Università degli Studi G. D'Annunzio,
`Chieti Scalo; Giovanni Corona, Centro Antidiabetico, Bologna; Alessandro Roberto Dodesini,
`Azienda Ospedaliera Papa Giovanni XXIII, Bergamo; Francesco Dotta, Azienda Ospedaliera
`Universitaria Senese, Siena; Roberto Fabris, Azienda Ospedaliera di Padova, Padova;
`Fabrizio Febo, Università degli Studi G. D'Annunzio, Chieti Scalo; Patrizia Di Fulvio,
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`Università degli Studi G. D'Annunzio, Chieti Scalo; Serena Isoni, ASL no2 Olbia, OLBIA;
`Laura Nigi, Azienda Ospedaliera Universitaria Senese, Siena; Lorenzo Di Pizio, Università
`degli Studi G. D'Annunzio, Chieti Scalo; Chiara Dal Prà, Azienda Ospedaliera di Padova,
`Padova; Cristiana Scaranna, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo; Roberto
`Serra, Azienda Ospedaliera di Padova, Padova; Alessandra Sforza, Centro Antidiabetico,
`Bologna; Camilla Tinari, Università degli Studi G. D'Annunzio, Chieti Scalo; Giancarlo
`Tonolo, ASL no2 Olbia, Olbia; Vania Torricelli, Azienda Ospedaliera Universitaria Senese,
`Siena; Roberto Trevisan, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo; Roberto
`Vettor, Azienda Ospedaliera di Padova, Padova; Stela Vujosevic, Azienda Ospedaliera di
`Padova, Padova; Eva Zabeo, Azienda Ospedaliera di Padova, Padova; Veronica Zanato,
`Azienda Ospedaliera di Padova, Padova.
`
`
`
`Malaysia: Wan Azman Wan Ahmad, University Malaya Medical Centre, Kuala Lumpur; Nor
`Hanim Amin, Sarawak General Hospital Heart Centre, Kota Samarahan; Yee Ling Cham,
`Sarawak General Hospital Heart Centre, Kota Samarahan; Seng Chua, Sarawak General
`Hospital Heart Centre, Kota Samarahan; Thurston Erng, Hospital Melaka, Melaka; Alan Yean
`Yi Fong, Sarawak General Hospital Heart Centre, Kota Samarahan; Abd Kahar Abd Ghapar,
`Hospital Serdang, Serdang; Ning Zan Khiew, Sarawak General Hospital Heart Centre, Kota
`Samarahan; Yueh Chien Kuan, Sarawak General Hospital, Kuching; Bik Kiu Lau, Sarawak
`General Hospital, Kuching; Gary Lee, Hospital Melaka, Melaka; Kien Chien Lim, Hospital
`Melaka, Melaka; Kauthaman A. Mahendran, Hospital Melaka, Melaka; Abdul Muizz Abd
`Malek, Hospital Serdang, Serdang; Tiong Kiam Ong, Sarawak General Hospital Heart
`Centre, Kota Samarahan; Frederick Rozario, Sarawak General Hospital, Kuching; Asri Said,
`Sarawak General Hospital Heart Centre, Kota Samarahan; Nor Ashikin Sari, University
`Malaya Medical Centre, Kuala Lumpur; Radhakrishna Sothiratnam, Columbia Asia Medical
`Center, Seremban; Ganiga Sridhar, University Malaya Medical Centre, Kuala Lumpur;
`Florence Tan, Sarawak General Hospital, Kuching; Sian Kong Tan, Sarawak General Hospital
`Heart Centre, Kota Samarahan; Lip Kai Tay, Hospital Serdang, Serdang; Julian Tey, Hospital
`Melaka, Melaka; Shalini Vijayasingham, Hospital Melaka, Melaka; Chi Yen Voon, Sarawak
`General Hospital Heart Centre, Kota Samarahan; Kuan Leong Yew, Sarawak General
`Hospital Heart Centre, Kota Samarahan; Chan, Sarawak General Hospital, Kuching.
`
`
`
`Mexico: Aurelia Baez-Campos, Instituto de Diabetes Obesidad y Nutricion S.C., Cuernavaca;
`Bertha Martinez-Nolasco, Centro de Investigacion Clinica Endocrinologica de Jalisco,
`Guadalajara; Carlos González-Valencia, Centro de Investigacion Clinica Endocrinologica de
`Jalisco, Guadalajara; Carlos Villasana-Galeana, Ultimate Medica S.A. de C.V., México D.F.;
`Carlos Olvera, Centro de Investigación Médico Biológica y Terapia, Guadalajara; Denisse
`Castillo Reveles, Centro de Estudios de Investigación Metabólicos y Cardiovasc, Tampico;
`Diana Larios-Mora, Centro de Investigacion Clinica Endocrinologica de Jalisco, Guadalajara;
`Efrain Montaño-Gonzalez, Centro de Investigación Médico Biológica y Terapia, Guadalajara;
`Elizabeth Pacheco Aranda, Fundacion Cardiovascular de Aguascalientes A.C.,
`Aguascalientes; Elvia Hernandez Lopez, Centro de Estudios de Investigación Metabólicos y
`Cardiovasc, Tampico; Emma Chavez Manzanera, Instituto Nacional de Ciencias Médicas y
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`Nutrición, Mexico City; Fabián Luna-Martínez, Ultimate Medica S.A. de C.V., México D.F.;
`Fernando Lopez-Hernandez, Centro de Investigacion Clinica Endocrinologica de Jalisco,
`Guadalajara;
`
`Francister Medina Alemán, Centro de Estudios de Investigación Metabólicos y Cardiovasc,
`Tampico; Ignacio Rodriguez Briones, Carioarritmias e Investigación S.C., San Luis Potosi;
`Irving Peralta-Cantu, Instituto de Diabetes Obesidad y Nutricion S.C., Cuernavaca; Israel
`Olvera-Alvarez, Clínicos Asociados BOCM, S.C., Mexico City; Jose Alfredo Haro Ortiz,
`Carioarritmias e Investigación S.C., San Luis Potosi; Jose de Jesus Marin-Lopez, Fundacion
`Cardiovascular de Aguascalientes A.C., Aguascalientes; Juan Garcia Garcia, Instituto
`Nacional de Ciencias Médicas y Nutrición, Mexico City; Juana Chávez Torres, Centro de
`Estudios de Investigación Metabólicos y Cardiovasc, Tampico; Leobardo Sauque-Reyna,
`Instituto de Diabetes Obesidad y Nutricion S.C., Cuernavaca; Lilia Aguilar-Parra, Centro de
`Investigacion Clinica Endocrinologica de Jalisco, Guadalajara; Luis Virgen-Carrillo, Centro de
`Investigacion Clinica Endocrinologica de Jalisco, Guadalajara; Luis Angel Amaya Morante,
`Centro de Estudios de Investigación Metabólicos y Cardiovasc, Tampico; Luis Carmona
`Furusho, Clínicos Asociados BOCM, S.C., Mexico City; Luz Reynaga, Centro de Estudios de
`Investigación Metabólicos y Cardiovasc, Tampico; Maria Montaño-Gonzalez, Centro de
`Investigación Médico Biológica y Terapia, Guadalajara; Maria del Carmen Juarez Cervantes,
`Fundacion Cardiovascular de Aguascalientes A.C., Aguascalientes; Norma Martinez-Trejo,
`Clínicos Asociados BOCM, S.C., Mexico City; Paola Gomez, Instituto Nacional de Ciencias
`Médicas y Nutrición, Mexico City; Patricia Diaz De Leon-Reyes, Centro de Investigación
`Médico Biológica y Terapia, Guadalajara; Paul-Baron Frenk, Ultimate Medica S.A. de C.V.,
`México D.F.; Pedro Sanchez Vargas, Instituto de Diabetes Obesidad y Nutricion S.C.,
`Cuernavaca; Rafael Margarito Violante Ortiz, Centro de Estudios de Investigación
`Metabólicos y Cardiovasc, Tampico; Raul Estrada Garcia, Carioarritmias e Investigación
`S.C., San Luis Potosi; Rocio Rodriguez Briones, Carioarritmias e Investigación S.C., San Luis
`Potosi;
`
`Rosa Gonzalez-Perez, Centro de Investigacion Clinica Endocrinologica de Jalisco,
`Guadalajara; Rosa Lopez Covarrubias, Fundacion Cardiovascular de Aguascalientes A.C.,
`Aguascalientes; Rosalinda Guerrero-Reyes, Fundacion Cardiovascular de Aguascalientes
`A.C., Aguascalientes; Sara Chong-Garcia Torres, Centro de Estudios de Investigación
`Metabólicos y Cardiovasc, Tampico; Silvia Jimenez-Ramos, Centro de Investigacion Clinica
`Endocrinologica de Jalisco, Guadalajara.
`
`
`
`Poland: Edyta Cichocka, Kat. i Klin. Chorob Wewnetrznych, Diabetologii i Nefrologii, Zabrze;
`Ewa Czernecka, Synexus Polska Sp. z o.o. Oddzial w Warszawie, Warszawa; Magda
`Dabrowska, Synexus Polska Sp. z o.o. Oddzial w Warszawie, Warszawa; Izabella Gladysz,
`Synexus Polska Sp. z o.o. Oddzial w Warszawie, Warszawa; Janusz Gumprecht, Kat. i Klin.
`Chorob Wewnetrznych, Diabetologii i Nefrologii, Zabrze; Katarzyna Jusiak, Synexus Polska
`Sp. z o.o. Oddzial w Warszawie, Warszawa; Dorota Knychas, Synexus Polska Sp. z o.o.
`Oddzial w Warszawie, Warszawa; Grazyna Laszewska, NSZOZ Osrodek Diabetologiczny
`POPULA S.C., Bialystok; Maria Mazerska, NSZOZ Osrodek Diabetologiczny POPULA S.C.,
`Bialystok; Katarzyna Nabrdalik, Kat. i Klin. Chorob Wewnetrznych, Diabetologii i Nefrologii,
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`Zabrze; Elzbieta Poplawska, NSZOZ Osrodek Diabetologiczny POPULA S.C., Bialystok;
`Andrzej Poplawski, NSZOZ Osrodek Diabetologiczny POPULA S.C., Bialystok; Urszula Puch,
`NSZOZ Osrodek Diabetologiczny POPULA S.C., Bialystok; Piotr Romanczuk, NZOZ Gdanska
`Poradnia Cukrzycowa, Gdansk; Wojciech Szydlowski, NZOZ CenterMed Lublin Sp. z o.o.,
`Lublin; Ewa Szyprowska, NZOZ CenterMed Lublin Sp. z o.o., Lublin; Alina Walczak, Synexus
`Polska Sp. z o.o. Oddzial w Warszawie, Warszawa; Bogumil Wolnik, NZOZ Gdanska Poradnia
`Cukrzycowa, Gdansk.
`
`
`
`Russian Federation: Yulia Arushanova (Matveeva), Academic out-patient clinic No1RAS,
`Saint-Petersburg; Kh. Astamirova, Academic out-patient clinic No1 RAS, Saint-Petersburg;
`Ekaterina Bukhalova, Clinical Hospital No1 NSMU, Novosibirsk; Veronika Dubova, Yaroslavl
`Regional Hospital, Yaroslavl; Irina Dvoryashina, First City Clinical Hospital of the Emergency
`Medical Care, Arkhangelsk; Elvira Edemskaya, Clinical Hospital No1 NSMU, Novosibirsk;
`Leylya Gaysina, KNMU, RH No1, Kazan; Svetlana Gromova, Saratov regional clinical
`hospital, Saratov; Irina Iskhakova (Tyutyunnikova), Clinical Hospital No1 NSMU,
`Novosibirsk; Marina Kalashnikova, Setchenov Moscow State Medical University, Moscow;
`Olga Kargapoltseva, Clinical Hospital No1NSMU, Novosibirsk; Lubov Kargina, SHI Saratov
`City Clinical Hospital No9, Saratov; Kamila Kholmatova, First City Clinical Hospital of the
`Emergency Medical Care, Arkhangelsk; Tatiana Kiseleva, KNMU, RH No1, Kazan; Ekaterina
`Komissarova, Penza Regional Clinical Hospital named after N.N. Burdenko, Penza; Svetlana
`Kovaleva, Penza Regional Clinical Hospital named after N.N. Burdenko, Penza; Elena
`Kovalevskaia, Academic out-patient clinic No1 RAS, Saint-Petersburg; Inga Krivosheeva,
`Clinical Hospital No1 NSMU, Novosibirsk; Tatiana Kufelkina, KNMU, RH No1, Kazan; Marina
`Kunitsyna, Saratov regional clinical hospit