GastroPlus(TM) 5.2.0
`
`4/7/2022
`
`1:11:35 PM
`
`Azacitidine 200 mg
`
`Drug Name:
`
`Dose
`200
`
`IR: Tablet
`Dosage Form
`
`Subsequent Dose 0
`
`Subsequent Dose Interval
`
`
`
`0
`
`Calculated Particle Size Distribution
`
`Built‐in Solubility‐pH Model
`
`Peff: 
`
`
`
`0.51
`
`0.25 h
`Stomach transit time:
`
`3.2088 h
`Small intestine transit time:
`
`12.57225 h
`Colon transit time:
`
`
`Stomach volume: 50 mL
`
`Small intestine length: 306.14 cm
`
`Small intestine radius: 1 cm
`
`Colon volume:
`
`1200 mL
`
`Qh:
`
`
`
`1.5 mL/min
`
`Opt logD Model
`C1Alpha:
`
`C2Alpha:
`
`C3Alpha:
`
`C4Alpha:
`
`Stom
`ASF's:
`0.
`
`
`
`0.18148
`1.0944
`0.0734
`0.31836
`Duod
`
`1.304
`
`
`
`Permeabilities: Stom
`
`Colon
`
`0.
`
`0.51
`
`
`
`J1
`
`1.376
`
`
`
`J2
`
`1.545
`
`
`
`I1
`
`1.76
`
`
`
`I2
`
`2.035
`
`
`I3
`
`2.421
`
`
`I4
`
`0.016
`
`
`Colon
`0.023
`
`
`Duod
`
`J1
`
`J2
`
`I1
`
`I2
`
`I3
`
`I4
`
`0.51
`
`
`
`0.51
`
`
`
`0.51
`
`
`
`0.51
`
`
`
`0.51
`
`
`
`0.51
`
`
`0.51
`
`
`pH's:
`
`Stom
`1.3
`
`Solubilities:
`Colon
`
`2.30E+00
`
`2.81E+01
`
`
`Duod
`6.
`
`Stom
`
`J1
`
`6.2
`
`
`
`J2
`
`6.4
`
`
`
`Duod
`
`J1
`
`I1
`
`6.6
`
`
`
`J2
`
`I2
`
`6.9
`
`
`
`I1
`
`I3
`
`7.4
`
`
`
`I2
`
`I4
`
`6.4
`
`
`
`I3
`
`Colon
`6.8
`
`
`I4
`
`2.31E+00
`
`2.30E+00
`
`
`2.31E+00
`
`
`2.30E+00
`2.31E+00
`
`
`2.31E+00
`
`
`2.30E+00
`
`Pharmacokinetic parameters:
`FPE = 
`0
`
`
`Clearance = 
`
`
`
`
`183.7709
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0001
`
`

`

`0.0755
`Vc/Vd = 
`
`Subject weight = 
`
`K12 = 
`27.8514
`
`K21 = 
`3.2778
`
`Fp = 
`99
`
`Half life = 
`Pred CMax = 
`
`
`
`
`
`
`
`
` 
`Total simulation time:
` 
` 
`J1UnRel J2UnRel I1UnRel I2UnRel I3UnRel I4UnRel CUnRel
`Time(h) StUnRel DUnRel
`
`
`
`
`
`
`
`
`
`
`SUndiss DUndiss J1Undiss
`J2Undiss
`ExUnRel Total Unrel. (mg)
`
`
`
`
`
`
`I1Undiss
`I3Undiss
`I4Undiss
`CUndiss ExUndiss
`I2Undiss
`
`
`
`
`
`Total. Undiss. (mg)
`SDiss
`J1Diss
`I1Diss
`DDiss
`J2Diss
`I2Diss
`I3Diss
`
`
`
`
`
`
`
`
`ExDiss
`Total. Diss. (mg)
`SDegrad DDegrad J1Degrad
`I4Diss
`CDiss
`
`
`
`
`
`
`
`J2Degrad
`I3Degrad
`I4Degrad
`I1Degrad
`I2Degrad
`
`
`
`
`
`CDegrad TotalDegrad
`SAbs
`J1Abs
`I1Abs
`I3Abs
`DAbs
`J2Abs
`I2Abs
`
`
`
`
`
`
`
`
`
`Abs Rate
`Net Ka Total Absorbed
`I4Abs
`CAbs
`
`
`
`
`
`
`First Pass %
`Fa %
`TotalExcreted
`Central Periph
`Cp (mg/L)
`CLiver 
`Time (h)
`
`
`
`
`
`
`StomEnt (mg)
`DuodEnt (mg)
`Juj1Ent (mg)
`Juj2Ent (mg)
`(mg/L)
`
`
`
`
`
`
`Ile1Ent (mg)
`Ile2Ent (mg)
`Ile3Ent (mg)
`Ile4Ent (mg)
`ColnEnt (mg)
`
`
`
`
`GB Amount (mg)
`(ng‐h/mL)
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`2.00E+2 0.E+0
`0.E+0
`0.E+0
`2.00E+2 0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`2.00E+2 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.e+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.e+0
`0.e+0
`0.e+0
`0.e+0
`0.e+0
`0.e+0
`0.E+0
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`8.E‐2
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`1.419E‐1
`0.E+0
`0.E+0
`0.E+0
`9.777E‐8
`9.777E‐8
`0.E+0
`
`
`
`
`
`
`1.854E‐1
`1.385E+2
`1.419E‐1
`4.02E‐2 0.E+0
`4.02E‐2 1.638E‐3
`
`
`
`
`
`
`1.667E‐4
`5.429E‐6
`4.428E+1
`7.44E+0 2.197E‐1
`6.021E‐3
`
`
`
`
`
`2.215E‐7
`
`
`
`
`
`7.848E+0
`1.025E‐12
`2.091E+2
`1.162E‐9
`3.42E‐8 9.344E‐10
`9.08E‐2 1.887E‐3
`3.91E‐5 8.327E‐7
`8.862E‐1
`
`
`
`
`
`
`5.133E‐2
`1.265E‐3
`4.83E‐12
`8.827E+0
`0.E+0
`4.492E‐1
`
`
`
`
`
`‐6.238E‐10
`3.114E‐5
`‐1.737E‐7
`‐2.919E‐10
`5.641E‐7
`
`
`
`
`
`3.263E‐3
`5.878E‐2
`4.185E‐2
`5.019E‐1
`2.509E‐1
`0.E+0
`
`
`
`
`
`1.034E‐12
`1.97E‐2 1.066E‐2
`3.397E‐3
`8.E‐2
`2.835E‐2
`
`
`
`
`
`
`3.711e‐1
`4.583e‐2
`1.182e‐3
`4.535e‐5
`0.e+0
`
`
`
`
`
`
`1.49e‐5 1.232e‐5
`3.822e‐7
`5.677e‐7
`6.944E‐2
`0.E+0
`
`
`
`
`
`1.6E‐1 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`1.46E‐8 1.307E‐2
`0.E+0
`0.E+0
`1.46E‐8 0.E+0
`0.E+0
`1.307E‐2
`
`
`
`
`
`
`
`
`6.046E‐3
`6.046E‐3
`2.005E‐2
`9.583E+1
`0.E+0
`4.545E‐4
`
`
`
`
`
`6.155E+1
`2.245E+1
`1.37E+0 7.611E‐2
`4.214E‐3
`2.658E‐4
`
`
`
`
`
`2.228E‐5
`2.032E‐10
`2.187E+2
`1.348E+1
`1.283E‐7
`
`
`
`
`
`2.856E+0
`2.51E‐2 1.041E‐3
`4.406E‐5
`3.491E‐6
`5.984E‐1
`
`
`
`
`
`1.946E‐7
`9.577E‐10
`1.696E+1
`0.E+0
`1.393E+0
`3.281E‐1
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`F %
`
`AUC
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.e+0
`
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.e+0
`
`
`76.8
`
`
`
`
`0.41
`1.05E‐1 Pred TMax = 
`
`
`
`
`1.12E+0 Pred AUC = 
`
`
`
`2.65E+2
`
`
`
`24 h
`
`
`
`
`
`
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0002
`
`

`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`‐2.321E‐6
`1.739E+0
`
`1.199E‐1
`
`0.e+0
`9.367e‐1
`
`1.377e‐4
`
`
`3.688E‐5
`8.154E‐4
`1.644E‐2
`
`
`
`9.266E‐2
`5.147E‐3
`‐1.696E‐8
`
`
`
`9.792E‐2
`2.035E‐10
`0.E+0
`2.634E‐1
`
`
`
`1.089E‐1
`1.6E‐1
`1.689E‐2
`
`
`
`
`8.948e‐4
`1.927e‐4
`1.407e‐2
`
`
`
`8.321E‐1
`0.E+0
`6.756e‐6
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.4E‐1
`
`
`
`
`
`
`
`
`1.332E‐3
`‐2.553E‐9
`‐2.553E‐9
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`7.528E‐5
`7.592E‐4
`0.E+0
`7.592E‐4
`2.249E‐3
`1.332E‐3
`
`
`
`
`
`3.027E‐1
`3.593E+0
`6.403E+1
`3.808E+1
`6.628E+1
`
`
`
`
`
`2.508E‐2
`2.99E‐4 2.389E‐6
`5.549E‐9
`2.277E+2
`2.318E‐3
`
`
`
`
`
`1.649E+0
`1.044E‐1
`6.491E‐3
`5.153E+0
`1.738E+1
`
`
`
`
`
`2.429E+1
`4.727E‐5
`4.025E‐6
`2.615E‐8
`4.086E‐4
`
`
`
`
`
`8.799E‐1
`6.693E‐2
`5.009E‐3
`3.653E‐4
`2.436E+0
`0.E+0
`
`
`
`
`
`1.093E‐5
`‐1.7E‐8 ‐9.49E‐8
`6.204E‐3
`1.117E‐1
`3.388E+0
`
`
`
`
`
`1.694E+0
`6.958E‐1
`5.55E‐9 1.974E‐1
`3.853E‐1
`0.E+0
`
`
`
`
`
`
`3.405E‐2
`1.322e+0
`6.163e‐1
`2.4E‐1
`1.971E‐1
`0.e+0
`
`
`
`
`
`
`5.235e‐2
`4.686e‐3
`8.196e‐4
`4.574e‐4
`1.563e‐5
`
`
`
`
`
`2.308e‐5
`2.865E+0
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`3.2E‐1
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`2.25E‐8 0.E+0
`2.25E‐8 1.333E‐4
`0.E+0
`0.E+0
`0.E+0
`1.333E‐4
`
`
`
`
`
`
`
`9.016E‐5
`0.E+0
`9.016E‐5
`1.046E‐5
`2.458E‐4
`4.585E+1
`
`
`
`
`
`5.121E+1
`6.635E+0
`7.529E‐1
`5.923E+1
`8.297E‐2
`
`
`
`
`
`1.77E‐3 1.88E‐5 5.868E‐8
`1.003E‐2
`2.362E+2
`2.008E+1
`
`
`
`
`
`
`7.392E+0
`3.201E+0
`2.716E‐1
`2.249E‐2
`1.871E‐3
`
`
`
`
`
`2.82E‐4 3.262E‐5
`2.766E‐7
`3.097E+1
`0.E+0
`3.407E+0
`
`
`
`
`
`
`1.669E+0
`1.709E‐1
`1.712E‐2
`1.713E‐3
`1.463E‐4
`
`
`
`
`
`9.089E‐8
`‐2.914E‐7
`6.765E‐3
`1.218E‐1
`5.265E+0
`
`
`
`
`
`2.632E+0
`5.868E‐8
`2.922E‐1
`0.E+0
`1.307E+0
`7.822E‐1
`
`
`
`
`
`3.2E‐1
`5.04E‐2 2.718E‐1
`0.e+0
`1.481e+0
`1.031e+0
`
`
`
`
`
`
`1.221e‐1
`1.431e‐2
`2.415e‐3
`3.409e‐5
`1.032e‐3
`
`
`
`
`
`4.996e‐5
`6.256E+0
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`4.E‐1
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`0.E+0
`
`1.795E‐7
`
`0.E+0
`
`
`
`
`1.795E‐7
`0.E+0
`0.E+0
`1.241E‐5
`1.241E‐5
`1.02E‐5 0.E+0
`1.02E‐5 1.332E‐6
`3.171E+1
`2.565E‐5
`
`
`
`
`
`5.139E+1
`6.074E+1
`1.012E+1
`2.954E‐2
`1.45E+0 1.991E‐1
`
`
`
`
`
`6.695E‐3
`9.012E‐5
`3.573E‐7
`2.194E+1
`2.443E+2
`
`
`
`
`
`9.393E+0
`5.147E+0
`5.478E‐1
`5.828E‐3
`5.655E‐2
`
`
`
`
`
`1.075E‐3
`1.584E‐4
`1.684E‐6
`4.241E+0
`0.E+0
`3.709E+1
`
`
`
`
`
`2.627E+0
`4.25E‐2 5.375E‐3
`3.387E‐1
`6.82E‐4 8.055E‐7
`
`
`
`
`
`
`‐6.515E‐7
`7.02E‐3 1.264E‐1
`7.256E+0
`3.628E+0
`0.E+0
`
`
`
`
`
`
`2.05E+0 3.573E‐7
`3.733E‐1
`6.439E‐2
`1.26E+0
`4.E‐1
`
`
`
`
`
`
`3.285E‐1
`1.466e+0
`1.428e+0
`0.e+0
`2.208e‐1
`
`
`
`
`
`
`3.24e‐2 5.796e‐3
`2.02e‐3 5.954e‐5
`1.086E+1
`0.E+0
`8.6e‐5
`
`
`
`
`
`
`4.8E‐1 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`1.058E‐6
`0.E+0
`0.E+0
`1.509E‐7
`0.E+0
`1.509E‐7
`0.E+0
`
`
`
`
`
`
`
`1.058E‐6
`2.647E‐6
`1.091E‐6
`0.E+0
`1.091E‐6
`1.596E‐7
`
`
`
`
`
`2.193E+1
`4.281E+1
`6.665E+1
`1.37E+1 2.376E+0
`3.902E‐1
`
`
`
`
`
`3.14E‐4 1.523E‐6
`2.52E+2 2.323E+1
`6.828E‐2
`1.908E‐2
`
`
`
`
`
`
`1.109E+1
`7.359E+0
`9.416E‐1
`1.163E‐1
`1.424E‐2
`
`
`
`
`
`
`
`
`‐6.748E‐9
`8.693E‐1
`
`
`
`2.598e‐1
`
`4.559e‐6
`
`
`
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0003
`
`

`

`0.E+0
`4.927E+0
`
`2.122E‐3
`
`9.29E+0 4.645E+0
`
`
`
`1.76e+0
`
`
`1.293e‐4
`
`
`7.178E‐6
`
`8.631E‐2
`
`7.083E‐3
`
`4.393E‐1
`
`
`
`1.195e‐2
`
`
`
`
`
`
`
`
`4.276E+1
`
`1.314E‐2
`
`1.275E‐1
`
`1.771E+0
`
`0.e+0
`1.344e+0
`
`3.73e‐3 9.197e‐5
`
`
`5.566E‐4
`3.091E‐3
`
`
`5.732E‐1
`3.688E+0
`
`
`‐1.189E‐6
`3.351E‐6
`
`
`2.884E+0
`0.E+0
`1.523E‐6
`
`
`4.8E‐1
`7.576E‐2
`3.686E‐1
`
`
`6.055e‐2
`3.406e‐1
`
`
`1.649E+1
`0.E+0
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`5.6E‐1
`0.E+0
`
`
`
`
`
`
`
`
`0.E+0
`8.926E‐8
`‐4.377E‐9
`0.E+0
`0.E+0
`0.E+0
`‐4.377E‐9
`
`
`
`
`
`
`2.351E‐7
`1.811E‐8
`1.105E‐7
`0.E+0
`8.926E‐8
`1.105E‐7
`
`
`
`
`
`3.485E+0
`1.709E+1
`6.937E+1
`1.517E+1
`3.468E+1
`
`
`
`
`
`4.475E‐2
`8.771E‐4
`5.065E‐6
`6.653E‐1
`1.336E‐1
`
`
`
`
`
`2.594E+2
`2.412E+1
`1.249E+1
`9.718E+0
`1.451E+0
`
`
`
`
`
`7.312E‐3
`1.565E‐3
`2.387E‐5
`2.082E‐1
`2.946E‐2
`
`
`
`
`
`4.794E+0
`8.709E‐1
`1.528E‐1
`4.803E+1
`5.475E+0
`0.E+0
`
`
`
`
`
`2.707E‐2
`5.206E‐3
`1.011E‐5
`‐1.86E‐6
`7.028E‐3
`
`
`
`
`
`1.265E‐1
`1.132E+1
`5.662E+0
`3.774E+0
`5.065E‐6
`0.E+0
`
`
`
`
`
`4.913E‐1
`2.279E+0
`5.6E‐1
`8.473E‐2
`3.952E‐1
`
`
`
`
`
`
`1.171e+0
`2.005e+0
`9.906e‐2
`2.182e‐2
`0.e+0
`4.714e‐1
`
`
`
`
`
`6.595e‐3
`1.325e‐4
`1.781e‐4
`2.292E+1
`0.E+0
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`6.4E‐1
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`4.36E‐7 0.E+0
`4.36E‐7 1.236E‐8
`1.236E‐8
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`1.049E+1
`1.157E‐8
`4.643E‐7
`0.E+0
`1.157E‐8
`1.977E‐9
`
`
`
`
`
`2.753E+1
`6.954E+1
`2.009E+1
`4.717E+0
`1.025E+0
`
`
`
`
`
`2.312E‐1
`9.103E‐2
`2.083E‐3
`1.404E‐5
`
`
`
`
`
`2.663E+2
`2.474E+1
`1.361E+1
`1.213E+1
`2.067E+0
`3.372E‐1
`
`
`
`
`
`3.74E‐3 6.617E‐5
`5.295E+1
`0.E+0
`5.396E‐2
`1.501E‐2
`
`
`
`
`
`
`5.904E+0
`5.898E+0
`1.224E+0
`2.447E‐1
`4.932E‐2
`
`
`
`
`
`‐2.532E‐6
`1.087E‐2
`2.502E‐5
`6.899E‐3
`1.242E‐1
`
`
`
`
`
`1.333E+1
`6.666E+0
`1.404E‐5
`5.313E‐1
`0.E+0
`4.695E+0
`
`
`
`
`
`2.759E+0
`6.4E‐1
`9.163E‐2
`4.115E‐1
`0.e+0
`
`
`
`
`
`
`2.159e+0
`1.47e‐1 3.615e‐2
`1.112e‐2
`9.842e‐1
`6.031e‐1
`
`
`
`
`
`1.84e‐4 2.31e‐4 2.999E+1
`0.E+0
`
`
`
`0.E+0
`7.2E‐1
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`‐6.511E‐9
`1.56E‐26
`0.E+0
`0.E+0
`‐6.511E‐9
`‐1.607E‐8
`
`
`
`
`
`
`‐8.43E‐26
`‐1.607E‐8
`1.824E‐9
`2.215E‐27
`1.824E‐9
`
`
`
`
`
`2.662E‐10
`‐2.017E‐8
`7.259E+0
`2.151E+1
`6.779E+1
`
`
`
`
`
`1.461E+0
`2.258E+1
`6.005E+0
`3.648E‐1
`1.661E‐1
`
`
`
`
`
`2.729E+2
`4.373E‐3
`3.387E‐5
`2.517E+1
`1.449E+1
`
`
`
`
`
`1.45E+1 2.773E+0
`5.061E‐1
`9.011E‐2
`2.766E‐2
`7.898E‐3
`
`
`
`
`
`1.596E‐4
`5.756E+1
`0.E+0
`6.235E+0
`6.97E+0 1.624E+0
`
`
`
`
`
`
`2.018E‐2
`5.385E‐5
`‐2.943E‐6
`3.635E‐1
`8.185E‐2
`
`
`
`
`6.724E‐3
`1.21E‐1 1.529E+1
`7.647E+0
`0.E+0
`5.628E+0
`
`
`
`
`
`
`5.613E‐1
`3.196E+0
`7.2E‐1
`9.68E‐2 4.199E‐1
`3.387E‐5
`
`
`
`
`
`0.e+0
`2.229e+0
`7.274e‐1
`2.025e‐1
`8.047e‐1
`
`
`
`
`
`5.532e‐2
`1.779e‐2
`2.511e‐4
`2.869e‐4
`3.754E+1
`
`
`
`
`
`0.E+0
`0.E+0
`8.E‐1
`
`0.E+0
`0.E+0
`
`
`‐1.256E‐24
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`
`‐1.791E‐9
`
`
`‐8.33E‐10
`
`
`
`0.E+0
`0.E+0
`
`
`2.25E‐25
`
`5.052E‐10
`
`
`
`0.E+0
`0.E+0
`
`
`‐1.791E‐9
`
`‐2.092E‐26
`
`
`
`0.E+0
`0.E+0
`
`
`‐8.33E‐10
`
`5.052E‐10
`
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0004
`
`

`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`6.469E+1
`1.661E+1
`5.021E+0
`
`
`
`8.326E‐3
`1.96E+0 5.35E‐1 2.785E‐1
`
`
`
`
`1.68E+1 3.553E+0
`2.546E+1
`1.518E+1
`
`
`
`1.513E‐2
`3.45E‐4 6.19E+1 0.E+0
`
`
`
`
`
`2.058E+0
`5.09E‐1 1.263E‐1
`3.424E‐2
`
`
`
`1.174E‐1
`1.72E+1 8.601E+0
`6.521E‐3
`
`
`
`3.582E+0
`5.829E‐1
`8.E‐1
`
`
`
`
`0.e+0
`2.228e+0
`6.445e‐1
`
`
`
`
`3.406e‐4
`3.451e‐4
`2.702e‐2
`
`
`
`
`‐2.018E‐9
`4.625E‐11
`7.286E+0
`2.451E+1
`
`
`2.791E+2
`7.321E‐5
`
`
`4.683E‐2
`1.4E‐1
`7.156E‐1
`
`
`7.986E+0
`6.487E+0
`
`
`‐2.655E‐6
`1.043E‐4
`
`6.56E+0 7.321E‐5
`0.E+0
`
`
`
`1.005E‐1
`4.226E‐1
`
`
`8.377e‐1
`2.63e‐1 7.931e‐2
`
`
`4.544E+1
`0.E+0
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`8.8E‐1
`0.E+0
`
`
`
`
`
`
`
`
`9.176E‐10
`2.235E‐10
`6.244E‐26
`0.E+0
`0.E+0
`2.235E‐10
`
`
`
`
`
`‐2.947E‐25
`2.933E‐10
`‐9.98E‐27
`2.933E‐10
`
`
`
`
`
`9.176E‐10
`6.072E+1
`1.269E+1
`3.473E+0
`1.773E‐11
`1.473E‐9
`
`
`
`
`
`4.358E‐1
`7.397E‐1
`2.505E+0
`8.508E+0
`2.588E+1
`
`
`
`
`
`1.57E+1 1.897E+1
`2.85E+2 2.566E+1
`1.466E‐2
`1.449E‐4
`
`
`
`
`
`
`2.051E‐1
`7.404E‐2
`2.68E‐2 6.827E‐4
`4.387E+0
`9.647E‐1
`
`
`
`
`
`8.935E+0
`2.516E+0
`6.599E+1
`6.679E+0
`0.E+0
`6.799E‐1
`
`
`
`
`
`5.41E‐2 1.861E‐4
`‐1.012E‐6
`1.838E‐1
`6.302E‐3
`1.134E‐1
`
`
`
`
`1.905E+1
`9.524E+0
`0.E+0
`7.482E+0
`1.449E‐4
`5.976E‐1
`
`
`
`
`
`3.914E+0
`8.8E‐1
`1.031E‐1
`4.211E‐1
`0.e+0
`
`
`
`
`
`
`5.078e‐1
`2.174e+0
`1.077e‐1
`9.301e‐1
`3.258e‐1
`
`
`
`
`
`3.906e‐2
`5.359E+1
`4.611e‐4
`4.054e‐4
`0.E+0
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`9.6E‐1
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐1.691E‐9
`0.E+0
`0.E+0
`8.969E‐10
`
`8.488E‐27
`‐1.691E‐9
`
`
`
`
`‐3.677E‐24
`‐9.221E‐26
`8.969E‐10
`2.187E‐10
`2.187E‐10
`
`
`
`
`‐5.701E‐10
`1.774E‐12
`2.402E+0
`9.621E+0
`5.625E+1
`
`
`
`
`3.075E+0
`2.671E+1
`9.625E+0
`9.745E‐1
`6.445E‐1
`
`
`
`
`
`2.907E+2
`2.581E+1
`1.61E+1 2.099E+1
`2.418E‐2
`2.665E‐4
`
`
`
`
`
`5.257E+0
`1.251E+0
`4.449E‐2
`2.866E‐1
`1.107E‐1
`
`
`
`
`
`6.985E+1
`6.822E+0
`9.809E+0
`2.989E+0
`1.256E‐3
`0.E+0
`
`
`
`
`
`8.74E‐1 2.55E‐1 8.068E‐2
`3.103E‐4
`2.894E‐6
`6.074E‐3
`
`
`
`
`
`
`1.093E‐1
`2.083E+1
`1.042E+1
`8.386E+0
`2.665E‐4
`0.E+0
`
`
`
`
`
`6.065E‐1
`4.193E+0
`9.6E‐1
`1.046E‐1
`4.164E‐1
`
`
`
`
`
`3.95e‐1 2.079e+0
`1.003e+0
`0.e+0
`3.883e‐1
`1.399e‐1
`
`
`
`
`
`
`5.4e‐2
`6.228e‐4
`4.68e‐4 6.19E+1 0.E+0
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`1.04E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐1.341E‐8
`‐1.341E‐8
`1.341E‐24
`0.E+0
`0.E+0
`
`
`
`
`
`‐1.089E‐23
`‐7.285E‐22
`3.206E‐10
`2.943E‐9
`
`
`
`7.242E+0
`‐1.012E‐8
`9.127E‐12
`1.661E+0
`
`
`
`1.233E+0
`3.649E+0
`2.706E+1
`1.061E+1
`
`
`
`
`3.78E‐2 4.613E‐4
`2.96E+2 2.59E+1 1.64E+1 2.285E+1
`
`
`
`
`
`
`1.57E+0 3.849E‐1
`1.58E‐1 7.001E‐2
`2.174E‐3
`
`
`
`
`
`6.93E+0 1.061E+1
`3.467E+0
`1.088E+0
`0.E+0
`
`
`
`
`
`1.147E‐1
`4.896E‐4
`1.026E‐5
`5.841E‐3
`
`
`
`
`2.255E+1
`1.127E+1
`9.268E+0
`4.613E‐4
`0.E+0
`
`
`
`
`4.419E+0
`1.04E+0 1.053E‐1
`4.094E‐1
`
`
`
`
`
`3.04e‐1 1.957e+0
`1.054e+0
`4.482e‐1
`1.747e‐1
`
`
`
`
`8.37e‐4 5.333e‐4
`
`
`
`7.03E+1 0.E+0
`1.12E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`
`
`2.943E‐9
`
`3.206E‐10
`5.156E+1
`
`9.094E‐1
`
`6.147E+0
`
`7.349E+1
`
`3.401E‐1
`
`1.051E‐1
`
`6.105E‐1
`
`0.e+0
`
`
`7.172e‐2
`
`
`0.E+0
`
`
`0.E+0
`
`
`0.E+0
`
`
`0.E+0
`
`
`0.E+0
`
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0005
`
`

`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1.431E‐8
`‐3.697E‐8
`4.96E‐24
`‐3.697E‐8
`0.E+0
`0.E+0
`
`
`
`
`1.56E‐9 ‐4.267E‐23
`1.56E‐9 6.614E‐11
`1.431E‐8
`‐2.776E‐21
`
`
`
`
`
`
`5.42E+0 4.687E+1
`2.699E+1
`1.143E+1
`1.149E+0
`‐2.096E‐8
`
`
`
`
`
`1.233E+0
`4.21E+0 1.507E+0
`5.644E‐2
`7.582E‐4
`3.011E+2
`
`
`
`
`
`2.597E+1
`1.663E+1
`2.455E+1
`7.041E+0
`1.918E+0
`
`
`
`
`
`7.694E+1
`4.998E‐1
`2.167E‐1
`1.052E‐1
`3.573E‐3
`
`
`
`
`
`7.009E+0
`1.133E+1
`3.943E+0
`1.32E+0 4.387E‐1
`0.E+0
`
`
`
`
`
`
`1.566E‐1
`7.374E‐4
`2.258E‐5
`5.605E‐3
`1.009E‐1
`
`
`
`
`
`2.419E+1
`1.21E+1 0.E+0
`1.012E+1
`7.582E‐4
`6.105E‐1
`
`
`
`
`
`
`1.12E+0 1.053E‐1
`0.e+0
`4.597E+0
`4.006E‐1
`
`
`
`
`
`
`1.818e+0
`1.086e+0
`2.112e‐1
`2.319e‐1
`5.033e‐1
`
`
`
`
`
`9.194e‐2
`7.873E+1
`1.116e‐3
`6.023e‐4
`0.E+0
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.2E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`‐1.006E‐8
`‐1.939E‐25
`‐1.006E‐8
`0.E+0
`0.E+0
`1.894E‐8
`
`
`
`
`
`8.423E‐22
`1.894E‐8
`6.422E‐10
`2.593E‐23
`6.422E‐10
`
`
`
`
`9.837E‐12
`9.544E‐9
`7.949E‐1
`4.036E+0
`4.231E+1
`
`
`
`
`
`1.209E+1
`4.74E+0 1.789E+0
`1.615E+0
`8.103E‐2
`2.656E+1
`
`
`
`
`
`3.06E+2 2.602E+1
`1.68E+1 2.609E+1
`7.926E+0
`1.192E‐3
`
`
`
`
`
`
`2.289E+0
`6.307E‐1
`2.873E‐1
`1.521E‐1
`5.619E‐3
`
`
`
`
`
`8.02E+1 0.E+0
`7.068E+0
`1.197E+1
`4.41E+0 1.564E+0
`5.5E‐1
`
`
`
`
`
`2.067E‐1
`5.367E‐3
`9.661E‐2
`1.067E‐3
`4.164E‐5
`
`
`
`
`
`2.577E+1
`1.289E+1
`1.095E+1
`1.192E‐3
`6.071E‐1
`0.E+0
`
`
`
`
`
`1.047E‐1
`0.e+0
`4.73E+0
`1.2E+0
`3.906E‐1
`1.757e‐1
`
`
`
`
`
`1.672e+0
`1.1e+0
`1.142e‐1
`5.522e‐1
`2.483e‐1
`1.472e‐3
`
`
`
`
`
`6.763e‐4
`8.713E+1
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.28E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`6.431E‐10
`0.E+0
`0.E+0
`
`
`
`
`6.189E‐26
`
`
`‐3.489E‐9
`6.431E‐10
`5.948E‐9
`‐1.961E‐23
`‐6.928E‐22
`‐3.489E‐9
`5.948E‐9
`
`
`
`
`3.798E+1
`2.992E+0
`5.498E‐1
`1.086E‐10
`3.326E‐9
`
`
`
`
`
`1.124E‐1
`2.07E+0 2.054E+0
`1.258E+1
`5.226E+0
`2.585E+1
`
`
`
`
`
`1.693E+1
`2.748E+1
`3.106E+2
`2.605E+1
`1.804E‐3
`
`
`
`
`
`3.701E‐1
`2.126E‐1
`8.793E+0
`2.678E+0
`7.765E‐1
`
`
`
`
`
`1.255E+1
`4.863E+0
`8.33E+1 0.E+0
`7.112E+0
`8.502E‐3
`
`
`
`
`
`
`1.492E‐3
`6.955E‐5
`1.818E+0
`6.729E‐1
`2.649E‐1
`
`
`
`
`
`0.E+0
`1.176E+1
`5.13E‐3 9.234E‐2
`2.729E+1
`1.364E+1
`
`
`
`
`
`
`1.804E‐3
`6.008E‐1
`4.823E+0
`1.28E+0 1.036E‐1
`
`
`
`
`
`
`0.e+0
`1.525e+0
`1.098e+0
`3.795E‐1
`1.323e‐1
`
`
`
`
`
`5.938e‐1
`2.847e‐1
`1.38e‐1 1.916e‐3
`7.568e‐4
`9.547E+1
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.36E+0 0.E+0
`
`
`
`
`
`
`
`
`
`
`1.013E‐9
`0.E+0
`0.E+0
`
`
`
`
`
`
`3.296E‐9
`1.013E‐9
`7.057E‐27
`3.771E‐9
`2.595E‐23
`3.771E‐9
`3.296E‐9
`6.001E‐22
`
`
`
`
`
`2.491E+1
`2.21E+0 3.394E+1
`3.803E‐1
`8.509E‐9
`2.051E‐10
`
`
`
`
`
`2.639E‐3
`2.545E+0
`2.342E+0
`1.29E+1 5.656E+0
`1.514E‐1
`
`
`
`
`
`3.08E+0
`3.15E+2 2.607E+1
`1.702E+1
`2.872E+1
`9.632E+0
`
`
`
`
`
`
`9.356E‐1
`4.647E‐1
`2.884E‐1
`1.244E‐2
`8.623E+1
`
`
`
`
`
`7.143E+0
`1.307E+1
`5.299E+0
`2.079E+0
`8.06E‐1
`0.E+0
`
`
`
`
`
`
`3.31E‐1 2.025E‐3
`1.086E‐4
`4.893E‐3
`8.808E‐2
`2.873E+1
`
`
`
`
`
`1.436E+1
`0.E+0
`1.253E+1
`2.639E‐3
`5.919E‐1
`4.879E+0
`
`
`
`
`
`1.36E+0 1.021E‐1
`3.677E‐1
`9.909e‐2
`0.e+0
`
`
`
`
`
`
`
`
`
`
`
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0006
`
`

`

`
`
`
`
`
`
`
`
`1.31E+1
`
`1.096E+0
`
`5.682E‐1
`0.e+0
`
`
`0.E+0
`
`
`
`
`
`
`
`
`
`
`
`6.275e‐1
`
`3.194e‐1
`
`
`
`1.627e‐1
`
`
`
`2.46e‐3
`
`
`
`
`
`1.38e+0 1.082e+0
`
`
`
`0.E+0
`8.458e‐4
`1.037E+2
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.44E+0 0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐1.444E‐10
`3.45E‐10
`‐1.117E‐26
`3.45E‐10
`0.E+0
`0.E+0
`
`
`
`
`
`5.369E‐10
`‐2.701E‐23
`5.369E‐10
`‐5.327E‐22
`‐1.444E‐10
`
`
`3.021E+1
`1.626E+0
`2.631E‐1
`9.767E‐11
`9.595E‐10
`
`
`
`
`
`1.987E‐1
`3.082E+0
`2.599E+0
`2.38E+1 1.307E+1
`6.023E+0
`
`3.749E‐3
`3.191E+2
`2.609E+1
`1.709E+1
`2.983E+1
`
`
`
`
`
`1.044E+1
`3.49E+0 1.106E+0
`5.707E‐1
`3.812E‐1
`1.767E‐2
`
`
`8.901E+1
`0.E+0
`7.167E+0
`1.353E+1
`5.714E+0
`2.342E+0
`
`
`
`
`4.045E‐1
`2.677E‐3
`1.615E‐4
`4.658E‐3
`9.478E‐1
`
`
`
`
`
`3.01E+1 1.505E+1
`0.E+0
`1.327E+1
`3.749E‐3
`8.385E‐2
`
`
`
`4.903E+0
`1.44E+0 1.002E‐1
`5.809E‐1
`3.554E‐1
`
`
`
`0.e+0
`7.395e‐2
`1.055e+0
`
`1.243e+0
`6.531e‐1
`3.517e‐1
`0.E+0
`1.877e‐1
`1.118E+2
`3.113e‐3
`9.453e‐4
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.52E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐1.027E‐9
`4.028E‐11
`4.028E‐11
`0.E+0
`0.E+0
`‐1.289E‐27
`
`
`
`
`4.446E‐22
`1.54E‐9 3.577E‐23
`1.54E‐9 2.03E‐10
`‐1.027E‐9
`
`
`
`
`
`9.732E‐10
`1.82E‐1 1.193E+0
`2.258E+1
`2.681E+1
`
`
`2.834E+0
`3.659E+0
`6.323E+0
`5.186E‐3
`2.547E‐1
`
`
`2.61E+1 1.714E+1
`3.231E+2
`1.12E+1 3.903E+0
`3.081E+1
`
`
`
`
`
`6.873E‐1
`4.925E‐1
`1.287E+0
`9.165E+1
`2.444E‐2
`0.E+0
`1.393E+1
`2.605E+0
`7.184E+0
`6.107E+0
`
`3.458E‐3
`4.846E‐1
`2.309E‐4
`7.965E‐2
`4.425E‐3
`
`
`
`
`1.571E+1
`5.186E‐3
`3.141E+1
`0.E+0
`1.398E+1
`
`
`
`1.52E+0 9.799E‐2
`4.898E+0
`3.425E‐1
`
`5.502e‐2
`1.018e+0
`1.113e+0
`3.807e‐1
`6.706e‐1
`
`
`
`
`2.122e‐1
`
`
`
`3.882e‐3
`1.058e‐3
`
`0.E+0
`1.197E+2
`0.E+0
`0.E+0
`0.E+0
`1.6E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`‐3.617E‐10
`4.987E‐27
`0.E+0
`0.E+0
`1.345E‐9
`‐3.617E‐10
`
`
`
`
`‐2.472E‐21
`‐5.739E‐10
`1.345E‐9
`‐5.739E‐10
`‐1.992E‐22
`
`4.834E‐10
`2.937E‐11
`1.259E‐1
`8.73E‐1 2.373E+1
`2.128E+1
`
`
`
`3.043E+0
`1.299E+1
`6.553E+0
`4.266E+0
`3.198E‐1
`
`
`
`
`
`3.268E+2
`2.611E+1
`7.009E‐3
`1.718E+1
`3.169E+1
`
`
`
`
`
`1.193E+1
`4.314E+0
`1.475E+0
`8.134E‐1
`6.234E‐1
`
`
`
`
`
`9.416E+1
`7.196E+0
`3.303E‐2
`0.E+0
`1.429E+1
`6.476E+0
`
`2.866E+0
`1.25E+0 5.707E‐1
`4.375E‐3
`3.197E‐4
`4.194E‐3
`
`
`3.265E+1
`7.549E‐2
`1.633E+1
`0.E+0
`1.466E+1
`7.009E‐3
`
`
`
`
`
`4.867E+0
`1.6E+0
`5.539E‐1
`9.552E‐2
`3.294E‐1
`
`
`
`9.929e‐1
`4.084e‐2
`0.e+0
`9.746e‐1
`
`
`
`
`
`6.803e‐1
`4.059e‐1
`2.358e‐1
`4.774e‐3
`1.185e‐3
`1.275E+2
`0.E+0
`
`
`
`
`0.E+0
`1.68E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`2.589E‐11
`9.129E‐27
`2.589E‐11
`‐2.604E‐10
`0.E+0
`0.E+0
`
`‐5.404E‐21
`‐2.604E‐10
`5.084E‐10
`‐4.882E‐22
`5.084E‐10
`
`4.94E‐11
`3.807E‐10
`8.705E‐2
`6.373E‐1
`2.096E+1
`
`
`
`
`1.994E+1
`6.714E+0
`3.222E+0
`4.895E+0
`1.278E+1
`
`
`
`
`
`3.304E+2
`2.611E+1
`1.72E+1 3.246E+1
`3.941E‐1
`9.276E‐3
`
`1.261E+1
`4.72E+0 1.669E+0
`7.747E‐1
`4.372E‐2
`
`
`9.654E+1
`0.E+0
`7.205E+0
`6.821E+0
`3.122E+0
`
`
`
`6.618E‐1
`5.435E‐3
`3.966E‐3
`1.408E+0
`
`9.479E‐1
`1.461E+1
`
`4.309E‐4
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0007
`
`

`

`9.276E‐3
`
`3.16E‐1
`
`4.27e‐1
`
`
`
`
`
`
`
`
`
`
`
`
`1.531E+1
`0.E+0
`1.691E+1
`7.14E‐2 3.383E+1
`
`
`
`
`
`1.68E+0 9.283E‐2
`5.383E‐1
`4.814E+0
`
`
`
`
`
`9.262e‐1
`6.829e‐1
`3.028e‐2
`8.829e‐1
`0.e+0
`
`
`
`
`2.578e‐1
`5.792e‐3
`1.33e‐3 1.35E+2 0.E+0
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`1.76E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`4.054E‐10
`1.221E‐10
`3.014E‐27
`1.221E‐10
`0.E+0
`0.E+0
`
`
`
`
`
`
`‐6.894E‐11
`‐1.577E‐21
`‐6.894E‐11
`‐1.982E‐22
`4.054E‐10
`
`
`1.848E+1
`5.589E‐10
`4.54E‐11
`6.021E‐2
`4.642E‐1
`
`
`
`
`
`5.535E+0
`1.858E+1
`6.809E+0
`3.369E+0
`1.247E+1
`
`
`
`
`
`1.722E+1
`3.338E+2
`2.612E+1
`4.777E‐1
`1.204E‐2
`
`
`
`
`
`1.089E+0
`3.314E+1
`1.325E+1
`5.118E+0
`1.867E+0
`
`
`
`
`
`1.488E+1
`9.88E+1 0.E+0
`7.211E+0
`9.469E‐1
`5.677E‐2
`
`
`
`
`
`
`7.142E+0
`3.371E+0
`1.568E+0
`7.57E‐1 6.64E‐3 5.674E‐4
`
`
`
`
`
`
`3.743E‐3
`
`
`
`6.737E‐2
`
`
`1.747E+1
`1.593E+1
`3.494E+1
`0.E+0
`1.76E+0 8.996E‐2
`1.204E‐2
`5.216E‐1
`4.742E+0
`
`
`
`
`
`
`0.e+0
`7.829e‐1
`3.025E‐1
`2.244e‐2
`8.745e‐1
`
`
`
`
`
`
`6.79e‐1 4.437e‐1
`6.937e‐3
`1.496e‐3
`1.423E+2
`2.778e‐1
`
`
`
`
`
`0.E+0
`1.84E+0 0.E+0
`
`
`0.E+0
`0.E+0
`
`
`1.458E‐21
`
`5.221E‐11
`
`1.725E+1
`
`5.703E‐1
`
`1.384E+1
`
`1.01E+2 0.E+0
`
`
`1.728E+0
`
`
`6.344E‐2
`5.041E‐1
`
`1.664e‐2
`0.e+0
`
`2.955e‐1
`
`1.92E+0 0.E+0
`
`
`0.E+0
`0.E+0
`
`
`4.009E‐20
`
`‐4.202E‐12
`1.163E+1
`
`1.932E‐2
`
`5.879E+0
`
`1.03E+2 0.E+0
`
`
`1.887E+0
`
`3.697E+1
`
`4.549E+0
`
`1.236e‐2
`
`9.604e‐3
`
`0.E+0
`2.E+0
`
`0.E+0
`0.E+0
`
`1.858E‐19
`
`1.971E‐11
`
`1.467E+1
`
`7.811E‐1
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐4.855E‐10
`‐2.102E‐11
`‐4.697E‐27
`‐2.102E‐11
`
`
`
`
`5.137E‐10
`6.177E‐22
`5.137E‐10
`‐4.855E‐10
`
`
`
`
`1.627E+1
`3.374E‐1
`4.165E‐2
`1.15E‐10
`
`
`
`
`6.179E+0
`3.484E+0
`6.841E+0
`1.208E+1
`
`
`
`
`3.374E+1
`1.724E+1
`3.37E+2 2.612E+1
`1.537E‐2
`
`
`
`
`2.067E+0
`1.236E+0
`1.14E+0 7.246E‐2
`5.506E+0
`
`
`
`
`1.513E+1
`7.439E+0
`3.612E+0
`7.216E+0
`
`
`
`
`7.992E‐3
`7.322E‐4
`3.524E‐3
`8.553E‐1
`
`
`
`
`
`
`1.651E+1
`1.537E‐2
`1.799E+1
`0.E+0
`3.599E+1
`
`
`1.84E+0 8.694E‐2
`2.889E‐1
`4.653E+0
`
`
`
`
`
`8.209e‐1
`6.693e‐1
`4.56e‐1
`6.926e‐1
`
`
`
`
`1.683e‐3
`1.494E+2
`0.E+0
`8.209e‐3
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐8.532E‐26
`‐1.048E‐9
`3.395E‐11
`‐1.048E‐9
`
`
`
`
`‐9.916E‐11
`7.172E‐21
`‐9.916E‐11
`3.395E‐11
`
`
`
`
`2.881E‐2
`2.449E‐1
`1.43E+1 1.594E+1
`‐1.116E‐9
`
`
`
`
`3.565E+0
`6.816E+0
`6.716E‐1
`6.815E+0
`
`
`
`
`1.725E+1
`3.427E+1
`1.439E+1
`2.612E+1
`3.4E+2
`
`
`
`
`2.266E+0
`1.388E+0
`1.355E+0
`9.106E‐2
`
`
`
`
`7.219E+0
`1.534E+1
`7.713E+0
`3.844E+0
`
`
`
`
`9.49E‐3 9.281E‐4
`9.557E‐1
`
`
`
`
`
`3.311E‐3
`5.96E‐2
`1.848E+1
`0.E+0
`1.707E+1
`1.932E‐2
`4.859E‐1
`
`
`
`
`1.92E+0 8.379E‐2
`2.753E‐1
`0.e+0
`
`
`
`
`
`
`6.116e‐1
`4.64e‐1 3.106e‐1
`7.666e‐1
`6.547e‐1
`
`
`
`
`1.896e‐3
`1.562E+2
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`‐2.84E‐9
`‐3.973E‐25
`‐2.84E‐9
`
`
`
`5.552E‐10
`1.837E‐10
`3.606E‐20
`
`
`‐2.058E‐9
`1.993E‐2
`1.774E‐1
`
`
`
`6.736E+0
`3.615E+0
`1.113E+1
`
`
`
`3.429E+2
`2.612E+1
`2.394E‐2
`
`
`
`
`
`
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`
`
`5.552E‐10
`
`1.837E‐10
`
`1.256E+1
`
`7.438E+0
`
`1.725E+1
`
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0008
`
`

`

`
`
`
`
`
`
`
`
`1.542E+0
`2.465E+0
`
`
`1.553E+1
`7.222E+0
`0.E+0
`
`
`1.057E+0
`1.113E‐2
`
`
`3.789E+1
`1.895E+1
`
`
`4.433E+0
`2.E+0
`
`
`5.391e‐1
`9.209e‐3
`
`
`3.229e‐1
`1.112e‐2
`
`
`
`6.238E+0
`3.473E+1
`1.489E+1
`
`
`
`1.049E+2
`1.591E+0
`1.128E‐1
`
`
`
`2.043E+0
`7.965E+0
`4.065E+0
`
`
`
`5.586E‐2
`1.158E‐3
`3.104E‐3
`
`
`
`4.671E‐1
`0.E+0
`1.76E+1 2.394E‐2
`
`
`
`
`0.e+0
`8.056E‐2
`2.618E‐1
`
`
`
`4.678e‐1
`7.126e‐1
`6.359e‐1
`
`
`
`0.E+0
`2.135e‐3
`1.628E+2
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.08E+0 0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`2.54E‐9 1.058E‐18
`‐1.179E‐8
`‐2.212E‐24
`‐1.179E‐8
`0.E+0
`0.E+0
`
`
`
`
`
`
`1.049E‐11
`4.888E‐10
`2.54E‐9 4.888E‐10
`2.173E‐19
`‐8.734E‐9
`
`
`
`
`
`1.378E‐2
`1.283E‐1
`1.102E+1
`1.347E+1
`1.06E+1 6.612E+0
`
`
`
`
`
`3.633E+0
`8.037E+0
`3.456E+2
`8.981E‐1
`2.928E‐2
`
`
`
`
`
`2.612E+1
`1.726E+1
`3.514E+1
`1.536E+1
`6.581E+0
`
`
`
`
`
`2.66E+0 1.697E+0
`1.846E+0
`1.38E‐1 1.068E+2
`
`
`
`
`
`
`7.223E+0
`0.E+0
`1.569E+1
`8.195E+0
`4.275E+0
`1.159E+0
`2.197E+0
`
`
`
`
`
`3.876E+1
`1.291E‐2
`1.423E‐3
`2.903E‐3
`5.225E‐2
`
`
`
`
`
`1.938E+1
`1.809E+1
`2.928E‐2
`4.48E‐1 4.306E+0
`0.E+0
`
`
`
`
`
`
`2.08E+0 7.726E‐2
`0.e+0
`6.895e‐3
`4.747e‐1
`2.484E‐1
`
`
`
`
`
`
`6.596e‐1
`6.137e‐1
`4.678e‐1
`1.274e‐2
`3.324e‐1
`
`
`
`
`
`2.402e‐3
`1.691E+2
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.16E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`1.223E‐8
`‐3.593E‐8
`‐3.593E‐8
`‐8.796E‐24
`0.E+0
`0.E+0
`
`
`
`
`
`
`2.31E‐9 9.736E‐11
`4.237E‐18
`2.31E‐9 9.082E‐19
`1.223E‐8
`
`
`
`
`
`9.275E‐2
`9.669E+0
`‐2.12E‐8
`9.534E‐3
`1.232E+1
`
`
`
`
`
`1.004E+1
`6.449E+0
`3.623E+0
`8.607E+0
`1.022E+0
`
`
`
`
`
`3.482E+2
`2.612E+1
`1.726E+1
`3.55E+1 1.578E+1
`3.538E‐2
`
`
`
`
`
`6.906E+0
`2.851E+0
`1.853E+0
`2.121E+0
`1.668E‐1
`
`
`
`
`
`7.225E+0
`1.584E+1
`8.406E+0
`4.474E+0
`1.086E+2
`0.E+0
`
`
`
`
`
`1.261E+0
`1.482E‐2
`2.347E+0
`
`
`
`
`
`2.709E‐3
`1.728E‐3
`1.856E+1
`3.538E‐2
`4.877E‐2
`3.957E+1
`1.978E+1
`0.E+0
`
`
`
`
`
`4.286E‐1
`4.171E+0
`2.16E+0 7.392E‐2
`2.351E‐1
`
`
`
`
`
`
`5.197e‐3
`4.175e‐1
`6.083e‐1
`5.888e‐1
`4.642e‐1
`0.e+0
`
`
`
`
`
`3.39e‐1 1.447e‐2
`1.752E+2
`2.699e‐3
`0.E+0
`
`
`
`
`0.E+0
`0.E+0
`2.24E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`6.282E‐8
`‐5.511E‐8
`‐1.649E‐24
`‐5.511E‐8
`0.E+0
`0.E+0
`
`
`
`
`
`
`1.072E‐8
`4.472E‐19
`‐5.257E‐19
`6.282E‐8
`1.072E‐8
`
`
`
`
`8.476E+0
`3.355E‐10
`1.912E‐8
`6.594E‐3
`6.695E‐2
`
`
`
`
`
`9.141E+0
`9.474E+0
`6.252E+0
`3.588E+0
`1.124E+1
`
`
`
`
`
`3.581E+1
`4.23E‐2 3.506E+2
`2.612E+1
`1.727E+1
`1.151E+0
`
`
`
`
`
`7.214E+0
`3.036E+0
`2.008E+0
`2.415E+0
`1.617E+1
`
`
`
`
`
`1.102E+2
`7.225E+0
`1.596E+1
`8.598E+0
`1.993E‐1
`0.E+0
`
`
`
`
`
`4.661E+0
`2.491E+0
`1.361E+0
`1.685E‐2
`2.072E‐3
`
`
`
`
`
`2.523E‐3
`
`
`
`
`
`
`1.9E+1
`4.032E+1
`2.016E+1
`0.E+0
`4.542E‐2
`4.23E‐2 4.092E‐1
`4.029E+0
`2.24E+0 7.057E‐2
`2.222E‐1
`
`
`
`
`
`
`3.951e‐3
`3.669e‐1
`5.591e‐1
`5.619e‐1
`0.e+0
`
`
`
`
`
`
`4.573e‐1
`1.809E+2
`3.428e‐1
`1.629e‐2
`3.028e‐3
`
`
`
`
`
`0.E+0
`2.32E+0 0.E+0
`
`
`0.E+0
`0.E+0
`
`
`
`0.E+0
`0.E+0
`
`
`‐1.664E‐8
`
`
`0.E+0
`0.E+0
`
`
`‐1.193E‐23
`
`
`0.E+0
`0.E+0
`
`
`‐1.664E‐8
`
`
`0.E+0
`
`4.187E‐8
`
`0.E+0
`
`
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0009
`
`

`

`0.E+0
`0.E+0
`
`3.899E‐9
`
`1.587E‐9
`
`6.504E+0
`
`1.009E+1
`
`1.727E+1
`
`2.31E+0 3.051E+0
`
`8.931E+0
`2.176E‐3
`5.867E‐2
`
`4.356e‐1
`
`4.301E‐18
`1.204E‐8
`1.526E‐18
`1.204E‐8
`4.187E‐8
`
`
`
`1.454E‐9
`7.426E+0
`4.829E‐2
`4.561E‐3
`4.021E‐8
`
`
`
`
`
`1.023E+1
`1.286E+0
`9.636E+0
`3.528E+0
`6.028E+0
`8.9E+0
`
`
`
`
`5.005E‐2
`2.612E+1
`1.727E+1
`3.608E+1
`3.529E+2
`
`
`
`
`
`1.653E+1
`7.503E+0
`3.216E+0
`2.16E+0 2.725E+0
`2.359E‐1
`
`
`
`
`
`1.118E+2
`7.226E+0
`1.607E+1
`8.772E+0
`0.E+0
`4.836E+0
`
`
`
`
`
`2.631E+0
`1.459E+0
`1.9E‐2
`2.458E‐3
`2.345E‐3
`4.222E‐2
`
`
`4.102E+1
`1.942E+1
`2.051E+1
`0.E+0
`5.005E‐2
`3.897E‐1
`
`
`
`3.882E+0
`2.32E+0 6.722E‐2
`2.094E‐1
`0.e+0
`
`3.222e‐1
`3.036e‐3
`5.123e‐1
`5.337e‐1
`
`
`
`
`3.44e‐1 1.82e‐2 3.388e‐3
`1.864E+2
`0.E+0
`
`
`0.E+0
`0.E+0
`2.4E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`‐5.325E‐9
`1.82E‐26
`‐5.325E‐9
`0.E+0
`0.E+0
`
`
`
`
`1.429E‐21
`4.289E‐22
`3.899E‐9
`1.587E‐9
`
`
`
`
`
`5.652E‐10
`1.923E‐10
`3.155E‐3
`3.481E‐2
`
`
`5.782E+0
`3.449E+0
`9.293E+0
`8.329E+0
`
`
`
`
`2.612E+1
`1.425E+0
`5.867E‐2
`3.551E+2
`
`
`
`
`1.685E+1
`7.775E+0
`3.389E+0
`3.632E+1
`1.617E+1
`7.226E+0
`2.765E‐1
`1.134E+2
`0.E+0
`
`2.888E‐3
`2.125E‐2
`5.E+0
`1.555E+0
`2.764E+0
`
`
`
`
`
`1.981E+1
`0.E+0
`3.916E‐2
`4.167E+1
`2.084E+1
`
`
`
`
`
`1.971E‐1
`3.731E+0
`2.4E+0
`6.388E‐2
`3.704E‐1
`
`
`5.045e‐1
`2.827e‐1
`0.e+0
`4.681e‐1
`2.362e‐3
`
`
`
`
`
`0.E+0
`3.426e‐1
`2.018e‐2
`3.782e‐3
`1.917E+2
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`2.48E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐1.874E‐9
`5.878E‐27
`‐1.874E‐9
`1.157E‐9
`0.E+0
`0.E+0
`
`1.357E‐23
`1.157E‐9
`3.498E‐10
`1.245E‐23
`3.498E‐10
`
`‐2.945E‐10
`3.396E‐11
`5.694E+0
`2.182E‐3
`2.509E‐2
`8.421E+0
`7.768E+0
`5.521E+0
`3.352E+0
`1.049E+1
`
`
`
`
`
`2.612E+1
`1.727E+1
`1.566E+0
`6.819E‐2
`3.572E+2
`
`
`
`
`
`1.714E+1
`8.028E+0
`3.554E+0
`2.456E+0
`3.653E+1
`
`
`
`
`
`7.227E+0
`1.626E+1
`3.391E+0
`3.214E‐1
`1.148E+2
`0.E+0
`
`
`1.648E+0
`2.36E‐2 3.362E‐3
`9.074E+0
`5.152E+0
`2.891E+0
`
`2.014E‐3
`3.626E‐2
`4.227E+1
`2.114E+1
`0.E+0
`2.017E+1
`
`2.48E+0 6.059E‐2
`6.819E‐2
`3.513E‐1
`3.577E+0
`
`
`
`2.48e‐1 4.266e‐1
`1.85E‐1
`0.e+0
`4.75e‐1 4.215e‐1
`
`
`
`
`
`1.967E+2
`0.E+0
`3.39e‐1 2.221e‐2
`
`
`
`
`0.E+0
`0.E+0
`2.56E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`‐2.078E‐10
`1.647E‐8
`1.826E‐25
`1.647E‐8
`0.E+0
`0.E+0
`
`
`7.673E‐11
`‐6.567E‐22
`‐2.078E‐10
`7.673E‐11
`3.924E‐23
`
`4.984E+0
`2.756E‐11
`1.639E‐8
`1.509E‐3
`1.808E‐2
`
`
`
`
`1.71E+0
`7.221E+0
`5.248E+0
`3.24E+0 1.084E+1
`7.617E+0
`
`
`
`
`
`7.861E‐2
`1.727E+1
`3.672E+1
`3.591E+2
`2.612E+1
`3.711E+0
`2.597E+0
`3.744E+0
`1.741E+1
`8.265E+0
`
`
`
`
`
`7.227E+0
`1.633E+1
`9.203E+0
`3.705E‐1
`1.162E+2
`0.E+0
`
`1.737E+0
`5.294E+0
`3.011E+0
`3.881E‐3
`
`
`
`
`3.35E‐2 4.283E+1
`2.142E+1
`0.E+0
`2.051E+1
`1.861E‐3
`
`
`
`3.326E‐1
`3.421E+0
`2.56E+0 5.735E‐2
`7.861E‐2
`
`
`
`0.e+0
`1.734E‐1
`1.497e‐3
`3.879e‐1
`4.455e‐1
`3.334e‐1
`
`
`
`
`
`
`
`
`1.865e‐3
`4.208e‐3
`0.E+0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`4.477e‐1
`
`0.E+0
`
`2.602E‐2
`
`4.058e‐1
`
`
`
`
`
`2.175e‐1
`2.43e‐2 4.667e‐3
`
`
`2.014E+2
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0010
`
`

`

`
`
`
`
`
`
`0.E+0
`2.64E+0 0.E+0
`
`
`0.E+0
`0.E+0
`
`
`1.53E‐22
`
`5.555E‐12
`6.877E+0
`
`1.855E+0
`
`1.764E+1
`
`1.175E+2
`
`3.125E+0
`
`3.091E‐2
`
`3.142E‐1
`
`1.222e‐3
`0.e+0
`
`3.259e‐1
`
`2.72E+0 0.E+0
`
`
`0.E+0
`
`
`0.E+0
`4.461E‐22
`
`3.805E‐11
`
`6.185E+0
`
`3.627E+2
`
`8.687E+0
`
`7.227E+0
`0.E+0
`
`1.905E+0
`
`4.382E+1
`
`3.109E+0
`
`1.015e‐3
`
`2.856e‐2
`
`0.E+0
`2.8E+0
`
`0.E+0
`0.E+0
`
`‐4.178E‐22
`
`1.995E‐11
`
`5.579E+0
`
`2.143E+0
`
`3.714E+1
`
`5.438E‐1
`
`3.332E+0
`
`2.616E‐2
`
`2.788E‐1
`
`8.574e‐4
`0.e+0
`
`3.065e‐1
`
`2.88E+0 0.E+0
`
`
`0.E+0
`0.E+0
`
`
`‐5.167E‐23
`
`6.013E‐11
`
`5.015E+0
`
`2.285E+0
`
`3.725E+1
`
`5.246E+0
`
`9.604E+0
`
`1.334E‐3
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`4.658E‐9
`‐7.422E‐9
`‐2.542E‐26
`‐7.422E‐9
`
`
`
`
`2.832E‐10
`‐1.547E‐23
`2.832E‐10
`4.658E‐9
`
`
`4.362E+0
`1.303E‐2
`1.044E‐3
`‐2.467E‐9
`
`
`
`1.115E+1
`3.117E+0
`4.969E+0
`6.693E+0
`
`
`
`
`3.688E+1
`1.727E+1
`3.61E+2 2.612E+1
`8.995E‐2
`
`
`
`
`3.86E+0 2.734E+0
`4.107E+0
`4.239E‐1
`8.484E+0
`
`
`
`
`1.639E+1
`9.32E+0 5.425E+0
`7.227E+0
`0.E+0
`
`
`
`
`
`1.823E+0
`2.852E‐2
`4.445E‐3
`1.717E‐3
`
`
`
`
`4.335E+1
`2.167E+1
`2.082E+1
`8.995E‐2
`0.E+0
`
`
`
`
`3.265E+0
`2.64E+0 5.418E‐2
`1.622E‐1
`
`
`
`
`
`1.906e‐1
`3.52e‐1 4.163e‐1
`3.888e‐1
`
`
`
`
`
`2.642e‐2
`5.159e‐3
`2.058E+2
`0.E+0
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`
`
`3.936E‐9
`‐7.429E‐9
`‐9.366E‐26
`‐7.429E‐9
`‐5.023E‐24
`3.936E‐9
`9.951E‐10
`9.951E‐10
`
`
`
`
`‐2.418E‐9
`7.22E‐4 9.403E‐3
`3.816E+0
`6.199E+0
`
`
`
`2.985E+0
`1.14E+1 1.999E+0
`4.686E+0
`1.022E‐1
`
`
`
`
`2.612E+1
`1.727E+1
`3.702E+1
`1.786E+1
`
`
`
`
`4.002E+0
`2.865E+0
`4.48E+0 4.817E‐1
`1.188E+2
`
`
`
`
`1.645E+1
`9.425E+0
`5.546E+0
`3.232E+0
`
`
`
`
`3.107E‐2
`5.054E‐3
`1.581E‐3
`2.846E‐2
`
`
`
`
`2.191E+1
`2.111E+1
`1.022E‐1
`2.962E‐1
`0.E+0
`
`
`
`
`2.72E+0 5.108E‐2
`1.514E‐1
`0.e+0
`
`
`
`
`
`
`1.67e‐1 3.187e‐1
`3.878e‐1
`3.709e‐1
`3.169e‐1
`
`
`
`
`5.682e‐3
`2.101E+2
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`1.007E‐8
`1.046E‐25
`
`1.007E‐8
`
`
`
`3.048E‐9
`1.116E‐9
`3.048E‐9
`1.116E‐9
`1.557E‐23
`
`
`
`3.339E+0
`1.427E‐8
`4.993E‐4
`6.794E‐3
`
`
`
`
`1.161E+1
`5.702E+0
`4.404E+0
`2.846E+0
`
`
`
`
`1.727E+1
`2.612E+1
`1.154E‐1
`3.644E+2
`
`
`
`
`2.99E+0 4.86E+0
`1.805E+1
`8.874E+0
`4.134E+0
`
`
`
`
`
`5.657E+0
`0.E+0
`7.227E+0
`1.65E+1 9.519E+0
`1.2E+2
`
`
`
`
`
`1.983E+0
`5.708E‐3
`1.453E‐3
`3.367E‐2
`
`
`
`
`4.426E+1
`2.213E+1
`2.138E+1
`1.154E‐1
`0.E+0
`
`
`
`
`2.954E+0
`2.8E+0
`4.808E‐2
`1.411E‐1
`
`
`
`
`
`1.464e‐1
`2.881e‐1
`3.601e‐1
`3.523e‐1
`
`
`
`
`3.071e‐2
`6.237e‐3
`2.14E+2 0.E+0
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`3.501E‐9
`7.057E‐9
`9.954E‐26
`7.057E‐9
`
`
`
`
`3.501E‐9
`
`
`
`1.861E‐9
`2.163E‐23
`1.861E‐9
`2.921E+0
`1.255E‐8
`3.454E‐4
`4.919E‐3
`
`
`
`
`1.177E+1
`5.243E+0
`4.126E+0
`2.702E+0
`
`
`
`
`1.727E+1
`2.612E+1
`1.295E‐1
`3.659E+2
`
`
`
`
`3.109E+0
`1.823E+1
`9.046E+0
`4.259E+0
`
`
`
`
`1.654E+1
`7.227E+0
`6.102E‐1
`1.211E+2
`0.E+0
`
`
`
`
`5.759E+0
`3.426E+0
`2.057E+0
`3.63E‐2 6.406E‐3
`
`
`
`
`4.466E+1
`2.233E+1
`2.401E‐2
`0.E+0
`2.163E+1
`
`
`
`
`
`
`
`
`
`
`
`
`
`Azacitidine 200mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1056-0011
`
`

`

`2.802E+0
`
`7.36e‐4 1.282e‐1
`
`3.286e‐2
`
`
`
`
`6.821e‐3
`
`
`
`
`
`2.619E‐1
`
`2.951e‐1
`
`
`0.e+0
`
`
`
`
`
`
`2.88E+0 4.516E‐2
`
`
`2.6e‐1
`3.334e‐1
`
`
`2.178E+2
`
`
`
`1.295E‐1
`1.313E‐1
`3.333e‐1
`0.E+0
`2.96E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`5.497E‐9
`1.252E‐9
`9.886E‐26
`1.252E‐9
`
`
`
`
`
`
`‐8.459E‐22
`1.358E‐9
`‐2.342E‐23
`1.358E‐9
`5.497E‐9
`
`
`
`
`
`‐8.397E‐12
`4.501E+0
`3.573E‐3
`2.555E+0
`2.389E‐4
`8.1E‐9
`
`
`
`
`
`4.811E+0
`2.556E+0
`1.187E+1
`2.424E+0
`3.853E+0
`
`
`
`
`
`1.445E‐1
`2.612E+1
`1.727E+1
`3.735E+1
`3.674E+2
`
`
`
`
`
`1.839E+1
`4.376E+0
`3.221E+0
`5.637E+0
`9.205E+0
`
`
`
`
`
`6.809E‐1
`7.227E+0
`1.658E+1
`9.68E+0
`0.E+0
`1.222E+2
`
`
`
`
`
`
`5.853E+0
`2.127E+0
`3.896E‐2
`7.148E‐3
`3.514E+0
`
`
`
`
`
`1.222E‐3
`2.251E+1
`0.E+0
`2.187E+1
`4.503E+1
`2.2E‐2
`
`
`
`
`
`
`1.445E‐1
`2.652E+0
`2.96E+0 4.235E‐2
`2.456E‐1
`
`
`
`