`from URL: https://ascopost.com/issues/january-25-2020/oral-cc-486-maintenance-
`therapy-extends-survival-in-older-patients-with-aml/
`
`Use of CC-486—an investigational oral form of azacitidine—as maintenance therapy
`significantly improved overall survival and relapse-free survival in older patients with newly
`diagnosed acute myeloid leukemia (AML) who were in remission following induction
`chemotherapy with or without consolidation therapy, according to results of the phase III
`QUAZAR AML-001 study. Results of the trial were reported at a late-breaking session of the
`2019 American Society of Hematology (ASH) Annual Meeting & Exposition.1
`
`CC-486 improved survival by 31% and improved relapse-free survival by 35% compared with
`placebo. These findings represent statistically significant and clinically significant -
`improvements.
`
`“This pivotal maintenance study demonstrates significant improvement in overall survival and
`relapse-free survival in a broad range of patients with AML in remission following induction
`chemotherapy with or without consolidation,” stated lead author Andrew H. Wei, MBBS, PhD,
`of Alfred Hospital and Monash University, Melbourne.
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`1
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`CELGENE 2103
`APOTEX v. CELGENE
`IPR2023-00512
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`Screen Capture completed by J L Mullins from “The ASCO Post” on October 10, 2023,
`from URL: https://ascopost.com/issues/january-25-2020/oral-cc-486-maintenance-
`therapy-extends-survival-in-older-patients-with-aml/
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`Screen Capture completed by J L Mullins from “The ASCO Post” on October 10, 2023,
`from URL: https://ascopost.com/issues/january-25-2020/oral-cc-486-maintenance-
`therapy-extends-survival-in-older-patients-with-aml/
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`Screen Capture completed by J L Mullins from “The ASCO Post” on October 10, 2023,
`from URL: https://ascopost.com/issues/january-25-2020/oral-cc-486-maintenance-
`therapy-extends-survival-in-older-patients-with-aml/
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`Screen Capture completed by J L Mullins from “The ASCO Post” on October 10, 2023,
`from URL: https://ascopost.com/issues/january-25-2020/oral-cc-486-maintenance-
`therapy-extends-survival-in-older-patients-with-aml/
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`Screen Capture completed by J L Mullins from “The ASCO Post” on October 10, 2023,
`from URL: https://ascopost.com/issues/january-25-2020/oral-cc-486-maintenance-
`therapy-extends-survival-in-older-patients-with-aml/
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