ÿ ÿ
`
`
`
`
`
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`#$ÿ!ÿ $ ÿ,ÿ$%&!' $ ' (&! ) ))* *$%&&&'+ '+**$+&$,+
`
`-./012ÿ4ÿ-560ÿ0//071-
`89:;<ÿ:>?@AÿAB9ÿC?DDE>F9ÿ;EDGDÿ?HÿIJKLMN8JOP
`
` ÿ
`
`ÿÿ
`
`ÿÿ
`
`QB9ÿD:H9ARÿC;?SF9ÿ?HÿIJKLMN8JOÿB:Dÿ>99<ÿ9TA9<DEU9FR
`9U:F@:A9V
`
`WXYZÿ\]ÿ^_`Yaÿ]_ÿ^X__a\ZbÿcÿdYecfa\Zbÿ`ge]\feYÿa^eYd_a\aÿhijkÿ]dYc]`YZ]lÿacmY]nÿ\aÿcÿoYnÿmc^]_dpÿqe\Z\^ceÿ]d\ce
`Yrcegc]\_Zalÿm_ee_stgfalÿcZuÿdYcets_deuÿYvfYd\YZ^Yÿagff_d]ÿ]XYÿacmY]nÿfd_weYÿ_mÿixyz{q|x}p
`
`ÿ x
`
`aÿfcd]ÿ_mÿ]XYÿÿ ÿfd_bdc`ÿm_dÿixyz{q|x}lÿc_g]ÿÿ_mÿ^ecud\\ZYt]dYc]Yuÿfc]\YZ]aÿ\Zÿ]XY
`fd_bdc`ÿsYdYÿm_ee_sYuÿm_dÿgfÿ]_ÿÿnYcdapÿXYÿcrYdcbYÿ]\`Yÿ_mÿ]XYÿa]gunÿm_ee_stgfÿscaÿc_g]ÿpÿnYcdap
`Merck 2070
`X\aÿXYefYuÿ]_ÿfd_r\uYÿcÿ^eYcdYdÿf\^]gdYÿ_mÿ]XYÿe_Zbt]Yd`ÿacmY]nÿfd_weYÿ_mÿixyz{q|x}p
`Hopewell v Merck
`IPR2023-00480
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
`#$ÿ!ÿ $ ÿ,ÿ$%&!' $ ' (&! ) ))* *$%&&&'+ '+**$+&$,+
`
`-./012ÿ4ÿ-560ÿ0//071-
`89:;<ÿ:>?@AÿAB9ÿC?DDE>F9ÿ;EDGDÿ?HÿIJKLMN8JOP
`
` ÿ
`
`ÿÿ
`
`ÿÿ
`
`QB9ÿD:H9ARÿC;?SF9ÿ?HÿIJKLMN8JOÿB:Dÿ>99<ÿ9TA9<DEU9FR
`9U:F@:A9V
`
`WXYZÿ\]ÿ^_`Yaÿ]_ÿ^X__a\ZbÿcÿdYecfa\Zbÿ`ge]\feYÿa^eYd_a\aÿhijkÿ]dYc]`YZ]lÿacmY]nÿ\aÿcÿoYnÿmc^]_dpÿqe\Z\^ceÿ]d\ce
`Yrcegc]\_Zalÿm_ee_stgfalÿcZuÿdYcets_deuÿYvfYd\YZ^Yÿagff_d]ÿ]XYÿacmY]nÿfd_weYÿ_mÿixyz{q|x}p
`
`ÿ x
`
`aÿfcd]ÿ_mÿ]XYÿÿ ÿfd_bdc`ÿm_dÿixyz{q|x}lÿc_g]ÿÿ_mÿ^ecud\\ZYt]dYc]Yuÿfc]\YZ]aÿ\Zÿ]XY
`fd_bdc`ÿsYdYÿm_ee_sYuÿm_dÿgfÿ]_ÿÿnYcdapÿXYÿcrYdcbYÿ]\`Yÿ_mÿ]XYÿa]gunÿm_ee_stgfÿscaÿc_g]ÿpÿnYcdap
`Merck 2070
`X\aÿXYefYuÿ]_ÿfd_r\uYÿcÿ^eYcdYdÿf\^]gdYÿ_mÿ]XYÿe_Zbt]Yd`ÿacmY]nÿfd_weYÿ_mÿixyz{q|x}p
`Hopewell v Merck
`IPR2023-00480
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`-.ÿ01ÿ23.ÿ42352ÿ06ÿ789:;<=8>ÿ01ÿ1?6@ÿ?2Aÿ@66@B.0C@ÿ63DÿE@3EF@ÿ.3ÿD@1.?D.ÿ789:;<=8>ÿ.D@?.G@2.ÿHÿI@?D1
`?6.@DÿB3GEF@.02Jÿ.K@0DÿHÿI@?DFIÿ.D@?.G@2.ÿB3LD1@1M
`
`ÿ
`
`ÿPQRSSSTÿUVWUXVÿYZ[Vÿ\VV]ÿ^_VZ^V`ÿaXW\ZXXbÿcd^YÿeZ[V]fXZ`ÿd]ÿ^YVÿ_VZXgcW_X`
`hV^^d]ai
`
`jklmnopkqÿstuvÿvwwvxys
`
`zK@1@ÿBF020B?Fÿ.D0?F1ÿ?F13ÿ@C?FL?.@Aÿ.K@ÿD014ÿ36ÿ10A@ÿ@66@B.1ÿ6D3Gÿ789:;<=8>MÿzK@ÿ.IE@1ÿ?2Aÿ1@D03L12@11ÿ36
`10A@ÿ@66@B.1ÿC?DIÿ6D3GÿE?.0@2.ÿ.3ÿE?.0@2.Mÿ{3Dÿ?ÿF01.ÿ36ÿE3110|F@ÿ10A@ÿ@66@B.1ÿ?2Aÿ.K@0Dÿ1IGE.3G1}ÿEF@?1@ÿ1@@
`.K@ÿ~ ÿM
`
`zK01ÿ01ÿ23.ÿ02.@2A@Aÿ.3ÿD@EF?B@ÿA01BL110321ÿ50.KÿI3LDÿK@?F.KB?D@ÿED3C0A@DMÿ-6ÿI3Lÿ.K024ÿI3Lÿ?D@ÿ@E@D0@2B02J
`?2Iÿ36ÿ.K@1@ÿ10A@ÿ@66@B.1ÿ3Dÿ1IGE.3G1}ÿEF@?1@ÿ.?F4ÿ.3ÿI3LDÿK@?F.KB?D@ÿED3C0A@Dÿ0GG@A0?.@FIM
`
` ÿÿ ÿ ÿÿ ÿ ÿÿÿÿ~
`
`ÿ~ ¡¢
`
`zD@?.G@2.ÿ50.Kÿ789:;<=8>ÿG?Iÿ02BD@?1@ÿI3LDÿD014ÿ36ÿA@C@F3E02JÿB?2B@DMÿ-2ÿBF020B?Fÿ1.LA0@1£
`
`¤3D4ÿ50.KÿI3LDÿK@?F.KB?D@ÿ.@?Gÿ.3ÿA@.@DG02@ÿ5K0BKÿB?2B@Dÿ1BD@@202J1ÿ?D@ÿ2@B@11?DIM
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
`-.ÿ01ÿ23.ÿ42352ÿ06ÿ789:;<=8>ÿ01ÿ1?6@ÿ?2Aÿ@66@B.0C@ÿ63DÿE@3EF@ÿ.3ÿD@1.?D.ÿ789:;<=8>ÿ.D@?.G@2.ÿHÿI@?D1
`?6.@DÿB3GEF@.02Jÿ.K@0DÿHÿI@?DFIÿ.D@?.G@2.ÿB3LD1@1M
`
`ÿ
`
`ÿPQRSSSTÿUVWUXVÿYZ[Vÿ\VV]ÿ^_VZ^V`ÿaXW\ZXXbÿcd^YÿeZ[V]fXZ`ÿd]ÿ^YVÿ_VZXgcW_X`
`hV^^d]ai
`
`jklmnopkqÿstuvÿvwwvxys
`
`zK@1@ÿBF020B?Fÿ.D0?F1ÿ?F13ÿ@C?FL?.@Aÿ.K@ÿD014ÿ36ÿ10A@ÿ@66@B.1ÿ6D3Gÿ789:;<=8>MÿzK@ÿ.IE@1ÿ?2Aÿ1@D03L12@11ÿ36
`10A@ÿ@66@B.1ÿC?DIÿ6D3GÿE?.0@2.ÿ.3ÿE?.0@2.Mÿ{3Dÿ?ÿF01.ÿ36ÿE3110|F@ÿ10A@ÿ@66@B.1ÿ?2Aÿ.K@0Dÿ1IGE.3G1}ÿEF@?1@ÿ1@@
`.K@ÿ~ ÿM
`
`zK01ÿ01ÿ23.ÿ02.@2A@Aÿ.3ÿD@EF?B@ÿA01BL110321ÿ50.KÿI3LDÿK@?F.KB?D@ÿED3C0A@DMÿ-6ÿI3Lÿ.K024ÿI3Lÿ?D@ÿ@E@D0@2B02J
`?2Iÿ36ÿ.K@1@ÿ10A@ÿ@66@B.1ÿ3Dÿ1IGE.3G1}ÿEF@?1@ÿ.?F4ÿ.3ÿI3LDÿK@?F.KB?D@ÿED3C0A@Dÿ0GG@A0?.@FIM
`
` ÿÿ ÿ ÿÿ ÿ ÿÿÿÿ~
`
`ÿ~ ¡¢
`
`zD@?.G@2.ÿ50.Kÿ789:;<=8>ÿG?Iÿ02BD@?1@ÿI3LDÿD014ÿ36ÿA@C@F3E02JÿB?2B@DMÿ-2ÿBF020B?Fÿ1.LA0@1£
`
`¤3D4ÿ50.KÿI3LDÿK@?F.KB?D@ÿ.@?Gÿ.3ÿA@.@DG02@ÿ5K0BKÿB?2B@Dÿ1BD@@202J1ÿ?D@ÿ2@B@11?DIM
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`-./01ÿ3454607
`
`89:;<=9ÿ?@ÿAB9ÿCD=Eÿ?@ÿFDCABÿG9@9:A=HÿG?ÿI?AÿA;E9ÿJKLMNOPKQÿD@ÿR?<ÿ;C9ÿSC9TI;IAÿ?Cÿ?@ÿ:BDUGF9;CDIT
`S?A9IAD;Uÿ;IGÿI?Aÿ<=DITÿ9@@9:ADV9ÿFDCABÿ:?IAC?UWÿX;AD9IA=ÿ=B?<UGÿ<=9ÿ9@@9:ADV9ÿFDCABÿ:?IAC?U
`Y:?IAC;:9SAD?IZÿ[BDU9ÿ?IÿAC9;A\9IAÿ[DABÿJKLMNOPKQÿ;IGÿ@?Cÿ;AÿU9;=Aÿ]ÿ\?IAB=ÿ;@A9CÿAB9ÿU;=AÿG?=9
`?@ÿ9;:BÿR9;CURÿAC9;A\9IAÿ:?<C=9W
`
`^_`ÿ-^__3ÿ64^^ÿ6_ab07
`
`P?[ÿFU??Gÿ:9UUÿ:?<IA=ÿB;V9ÿB;SS9I9Gÿ;IGÿ\;RÿDI:C9;=9ÿAB9ÿCD=Eÿ?@ÿDI@9:AD?I=ÿG<CDITÿAC9;A\9IA
`[DABÿJKLMNOPKQWÿc?<CÿB9;UAB:;C9ÿSC?VDG9Cÿ[DUUÿG?ÿFU??GÿA9=A=ÿF9@?C9HÿG<CDITHÿ;IGÿ;@A9CÿR?<C
`AC9;A\9IAÿ[DABÿJKLMNOPKQHÿ;=ÿI99G9GW
`
`74/._a7ÿ.b5460._b7
`
`X;AD9IA=ÿB;V9ÿ9dS9CD9I:9Gÿe8HÿB9S;ADAD=ÿ8ÿ?CÿOHÿ;IGÿ=BDITU9=ÿYB9CS9=ÿf?=A9CZWÿg;A;Uÿ:;=9=ÿ?@ÿe8ÿYh
`:;=9Zÿ;IGÿB9S;ADAD=ÿYhÿ:;=9ZÿB;V9ÿB;SS9I9Gÿ[DABÿ:U;GCDFDI9ÿG<CDITÿ:UDID:;Uÿ=A<GD9=WÿiIÿ:UDID:;U
`=A<GD9=j
`
`e;UEÿA?ÿR?<CÿB9;UAB:;C9ÿSC?VDG9CÿA?ÿ\;E9ÿ=<C9ÿR?<CÿV;::DI;AD?I=ÿ;C9ÿ<SÿA?ÿG;A9W
`
`k]lÿ?@ÿJKLMNOPKQmAC9;A9GÿS;AD9IA=ÿG9V9U?S9Gÿ;ÿB9CS9=ÿVDC;UÿDI@9:AD?IHÿ?@ÿ[BD:Bÿnlÿ[9C9ÿB9CS9=ÿf?=A9Cÿ;IGÿnW]lÿ[9C9
`
`?C;UÿB9CS9=W
`
`z
`
`nlÿ?@ÿSU;:9F?ÿS;AD9IA=ÿG9V9U?S9Gÿ;ÿB9CS9=ÿVDC;UÿDI@9:AD?IHÿ?@ÿ[BD:BÿoWnlÿ[9C9ÿB9CS9=ÿf?=A9Cÿ;IGÿhWnlÿ[9C9ÿ?C;UÿB9CS9=W
`
`p/_q/477.r4ÿsa^0.5_6t^ÿ^4au_4b64p1t^_pt01vÿwps^x
`
`XJPÿD=ÿ;ÿC;C9ÿFC;DIÿDI@9:AD?IÿAB;Aÿ<=<;UURÿU9;G=ÿA?ÿG9;ABÿ?Cÿ=9V9C9ÿGD=;FDUDARWÿN?ÿ:;=9=ÿ?@ÿXJPÿB;V9
`F99Iÿ=99IÿDIÿJyÿS;AD9IA=ÿA;EDITÿJKLMNOPKQHÿF<AÿDAÿ\;RÿB;SS9IÿDIÿS9?SU9ÿ[DABÿ[9;E9I9G
`D\\<I9ÿ=R=A9\=W
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
`-./01ÿ3454607
`
`89:;<=9ÿ?@ÿAB9ÿCD=Eÿ?@ÿFDCABÿG9@9:A=HÿG?ÿI?AÿA;E9ÿJKLMNOPKQÿD@ÿR?<ÿ;C9ÿSC9TI;IAÿ?Cÿ?@ÿ:BDUGF9;CDIT
`S?A9IAD;Uÿ;IGÿI?Aÿ<=DITÿ9@@9:ADV9ÿFDCABÿ:?IAC?UWÿX;AD9IA=ÿ=B?<UGÿ<=9ÿ9@@9:ADV9ÿFDCABÿ:?IAC?U
`Y:?IAC;:9SAD?IZÿ[BDU9ÿ?IÿAC9;A\9IAÿ[DABÿJKLMNOPKQÿ;IGÿ@?Cÿ;AÿU9;=Aÿ]ÿ\?IAB=ÿ;@A9CÿAB9ÿU;=AÿG?=9
`?@ÿ9;:BÿR9;CURÿAC9;A\9IAÿ:?<C=9W
`
`^_`ÿ-^__3ÿ64^^ÿ6_ab07
`
`P?[ÿFU??Gÿ:9UUÿ:?<IA=ÿB;V9ÿB;SS9I9Gÿ;IGÿ\;RÿDI:C9;=9ÿAB9ÿCD=Eÿ?@ÿDI@9:AD?I=ÿG<CDITÿAC9;A\9IA
`[DABÿJKLMNOPKQWÿc?<CÿB9;UAB:;C9ÿSC?VDG9Cÿ[DUUÿG?ÿFU??GÿA9=A=ÿF9@?C9HÿG<CDITHÿ;IGÿ;@A9CÿR?<C
`AC9;A\9IAÿ[DABÿJKLMNOPKQHÿ;=ÿI99G9GW
`
`74/._a7ÿ.b5460._b7
`
`X;AD9IA=ÿB;V9ÿ9dS9CD9I:9Gÿe8HÿB9S;ADAD=ÿ8ÿ?CÿOHÿ;IGÿ=BDITU9=ÿYB9CS9=ÿf?=A9CZWÿg;A;Uÿ:;=9=ÿ?@ÿe8ÿYh
`:;=9Zÿ;IGÿB9S;ADAD=ÿYhÿ:;=9ZÿB;V9ÿB;SS9I9Gÿ[DABÿ:U;GCDFDI9ÿG<CDITÿ:UDID:;Uÿ=A<GD9=WÿiIÿ:UDID:;U
`=A<GD9=j
`
`e;UEÿA?ÿR?<CÿB9;UAB:;C9ÿSC?VDG9CÿA?ÿ\;E9ÿ=<C9ÿR?<CÿV;::DI;AD?I=ÿ;C9ÿ<SÿA?ÿG;A9W
`
`k]lÿ?@ÿJKLMNOPKQmAC9;A9GÿS;AD9IA=ÿG9V9U?S9Gÿ;ÿB9CS9=ÿVDC;UÿDI@9:AD?IHÿ?@ÿ[BD:Bÿnlÿ[9C9ÿB9CS9=ÿf?=A9Cÿ;IGÿnW]lÿ[9C9
`
`?C;UÿB9CS9=W
`
`z
`
`nlÿ?@ÿSU;:9F?ÿS;AD9IA=ÿG9V9U?S9Gÿ;ÿB9CS9=ÿVDC;UÿDI@9:AD?IHÿ?@ÿ[BD:BÿoWnlÿ[9C9ÿB9CS9=ÿf?=A9Cÿ;IGÿhWnlÿ[9C9ÿ?C;UÿB9CS9=W
`
`p/_q/477.r4ÿsa^0.5_6t^ÿ^4au_4b64p1t^_pt01vÿwps^x
`
`XJPÿD=ÿ;ÿC;C9ÿFC;DIÿDI@9:AD?IÿAB;Aÿ<=<;UURÿU9;G=ÿA?ÿG9;ABÿ?Cÿ=9V9C9ÿGD=;FDUDARWÿN?ÿ:;=9=ÿ?@ÿXJPÿB;V9
`F99Iÿ=99IÿDIÿJyÿS;AD9IA=ÿA;EDITÿJKLMNOPKQHÿF<AÿDAÿ\;RÿB;SS9IÿDIÿS9?SU9ÿ[DABÿ[9;E9I9G
`D\\<I9ÿ=R=A9\=W
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
`12/19/23, 6:59 PM
` ÿ ÿ
`
`
`Side Effects & Safety Info | Mavenclad® (cladribine) Tablets
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`LIVER PROBLEMS
`-./01ÿ3145-067
`
`MAVENCLAD maycauseliver problems. Your healthcare provider should do bloodtests to check
`89:;<=>9?ÿABCÿDBEFGÿHIJGKÿLKMNHGAFOÿPMEKÿQGBHRQDBKGÿLKMJISGKÿFQMEHSÿSMÿNHMMSÿRGFRFÿRMÿDQGDT
`your liver before you start taking MAVENCLAD.In clinical studies:
`CMEKÿHIJGKÿNGUMKGÿCMEÿFRBKRÿRBTIVWÿ89:;<=>9?OÿXVÿDHIVIDBHÿFRESIGFY
`
`PATIENTS ON PLACEBO
`PATIENTS ON MAVENCLAD
`_—_—sng Vs
`oe
`HAD LIVER
`o
`HAD LIVER
`
`0.3% PROBLEMS
`(2 OUT OF 662 PATIENTS)
`
`O 7 PROBLEMS
`(0 OUT OF 641 PATIENTS)
`
`h ALLERGIC REACTIONS (HYPERSENSITIVITIES)
`Z--01[.\ÿ10Z\].4^7ÿ_`a30170^7.]./.].07b
`MAVENCLADcan cause serious allergic reactions such as skin rash, swelling or itching of the face,
`89:;<=>9?ÿDBVÿDBEFGÿFGKIMEFÿBHHGKWIDÿKGBDRIMVFÿFEDQÿBFÿFTIVÿKBFQcÿFdGHHIVWÿMKÿIRDQIVWÿMUÿRQGÿUBDGc
`lips, tongueor throat, or trouble breathing. Stop your treatment with MAVENCLADand goto the
`HILFcÿRMVWEGÿMKÿRQKMBRcÿMKÿRKMENHGÿNKGBRQIVWOÿeRMLÿCMEKÿRKGBRAGVRÿdIRQÿ89:;<=>9?ÿBVSÿWMÿRMÿRQG
`closest emergency room for help right away if you have anysigns or symptomsofallergic reactions.
`DHMFGFRÿGAGKWGVDCÿKMMAÿUMKÿQGHLÿKIWQRÿBdBCÿIUÿCMEÿQBJGÿBVCÿFIWVFÿMKÿFCALRMAFÿMUÿBHHGKWIDÿKGBDRIMVFO
`
`C2
`
`HEART FAILURE
``0Z1]ÿfZ.-g10
`
`MAVENCLAD maycause heart failure, which means your heart may not pump aswell asit should.
`89:;<=>9?ÿABCÿDBEFGÿQGBKRÿUBIHEKGcÿdQIDQÿAGBVFÿCMEKÿQGBKRÿABCÿVMRÿLEALÿBFÿdGHHÿBFÿIRÿFQMEHSO
`Call your healthcare provider or go to the closest emergency room for medical help right awayif
`=BHHÿCMEKÿQGBHRQDBKGÿLKMJISGKÿMKÿWMÿRMÿRQGÿDHMFGFRÿGAGKWGVDCÿKMMAÿUMKÿAGSIDBHÿQGHLÿKIWQRÿBdBCÿIU
`you haveanysigns or symptomsof heartfailure. In clinical studies:
`CMEÿQBJGÿBVCÿFIWVFÿMKÿFCALRMAFÿMUÿQGBKRÿUBIHEKGOÿXVÿDHIVIDBHÿFRESIGFY
`
`PATIENTS ON MAVENCLAD*
`
`PATIENTS ON PLACEBO
`
`VS
`
`@,
`
`HADHEART
`
`0.05 7e FAILURE
`(1 OUT OF 1,976 PATIENTS)
`
`Oy
`
`HAD HEART
`
`0% FAILURE
`(0 OUT OF 802 PATIENTS)
`
`“Includes patients treated with both oral and IV formsof cladribine.
`hXVDHESGFÿLBRIGVRFÿRKGBRGSÿdIRQÿNMRQÿMKBHÿBVSÿX:ÿUMKAFÿMUÿDHBSKINIVGO
`
`https://web.archive.orghweb/20231 004232146/https:/Avww.mavenclad.com/en/home/why-mavenclad/safety-and-side-effects.html
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`4/15
`*
`
`
`
`LIVER PROBLEMS
`-./01ÿ3145-067
`
`MAVENCLAD maycauseliver problems. Your healthcare provider should do bloodtests to check
`89:;<=>9?ÿABCÿDBEFGÿHIJGKÿLKMNHGAFOÿPMEKÿQGBHRQDBKGÿLKMJISGKÿFQMEHSÿSMÿNHMMSÿRGFRFÿRMÿDQGDT
`your liver before you start taking MAVENCLAD.In clinical studies:
`CMEKÿHIJGKÿNGUMKGÿCMEÿFRBKRÿRBTIVWÿ89:;<=>9?OÿXVÿDHIVIDBHÿFRESIGFY
`
`PATIENTS ON PLACEBO
`PATIENTS ON MAVENCLAD
`_—_—sng Vs
`oe
`HAD LIVER
`o
`HAD LIVER
`
`0.3% PROBLEMS
`(2 OUT OF 662 PATIENTS)
`
`O 7 PROBLEMS
`(0 OUT OF 641 PATIENTS)
`
`h ALLERGIC REACTIONS (HYPERSENSITIVITIES)
`Z--01[.\ÿ10Z\].4^7ÿ_`a30170^7.]./.].07b
`MAVENCLADcan cause serious allergic reactions such as skin rash, swelling or itching of the face,
`89:;<=>9?ÿDBVÿDBEFGÿFGKIMEFÿBHHGKWIDÿKGBDRIMVFÿFEDQÿBFÿFTIVÿKBFQcÿFdGHHIVWÿMKÿIRDQIVWÿMUÿRQGÿUBDGc
`lips, tongueor throat, or trouble breathing. Stop your treatment with MAVENCLADand goto the
`HILFcÿRMVWEGÿMKÿRQKMBRcÿMKÿRKMENHGÿNKGBRQIVWOÿeRMLÿCMEKÿRKGBRAGVRÿdIRQÿ89:;<=>9?ÿBVSÿWMÿRMÿRQG
`closest emergency room for help right away if you have anysigns or symptomsofallergic reactions.
`DHMFGFRÿGAGKWGVDCÿKMMAÿUMKÿQGHLÿKIWQRÿBdBCÿIUÿCMEÿQBJGÿBVCÿFIWVFÿMKÿFCALRMAFÿMUÿBHHGKWIDÿKGBDRIMVFO
`
`C2
`
`HEART FAILURE
``0Z1]ÿfZ.-g10
`
`MAVENCLAD maycause heart failure, which means your heart may not pump aswell asit should.
`89:;<=>9?ÿABCÿDBEFGÿQGBKRÿUBIHEKGcÿdQIDQÿAGBVFÿCMEKÿQGBKRÿABCÿVMRÿLEALÿBFÿdGHHÿBFÿIRÿFQMEHSO
`Call your healthcare provider or go to the closest emergency room for medical help right awayif
`=BHHÿCMEKÿQGBHRQDBKGÿLKMJISGKÿMKÿWMÿRMÿRQGÿDHMFGFRÿGAGKWGVDCÿKMMAÿUMKÿAGSIDBHÿQGHLÿKIWQRÿBdBCÿIU
`you haveanysigns or symptomsof heartfailure. In clinical studies:
`CMEÿQBJGÿBVCÿFIWVFÿMKÿFCALRMAFÿMUÿQGBKRÿUBIHEKGOÿXVÿDHIVIDBHÿFRESIGFY
`
`PATIENTS ON MAVENCLAD*
`
`PATIENTS ON PLACEBO
`
`VS
`
`@,
`
`HADHEART
`
`0.05 7e FAILURE
`(1 OUT OF 1,976 PATIENTS)
`
`Oy
`
`HAD HEART
`
`0% FAILURE
`(0 OUT OF 802 PATIENTS)
`
`“Includes patients treated with both oral and IV formsof cladribine.
`hXVDHESGFÿLBRIGVRFÿRKGBRGSÿdIRQÿNMRQÿMKBHÿBVSÿX:ÿUMKAFÿMUÿDHBSKINIVGO
`
`https://web.archive.orghweb/20231 004232146/https:/Avww.mavenclad.com/en/home/why-mavenclad/safety-and-side-effects.html
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`4/15
`*
`
`
`
`12/19/23, 6:59 PM
` ÿ ÿ
`
`
`Side Effects & Safety Info | Mavenclad® (cladribine) Tablets
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`Common side effects seen in clinical trials
`-.//.0ÿ2345ÿ5665782ÿ2550ÿ30ÿ793037:9ÿ8;3:92
`
`Someof the most commonside effects experienced by patients included:
`<=>?ÿ=AÿBC?ÿ>=DBÿE=>>=FÿDGH?ÿ?AA?EBDÿ?IJ?KG?FE?HÿLMÿJNBG?FBDÿGFEOPH?HQ
`
`UPPER RESPIRATORY INFECTION
`
`PATIENTS
`ON MAVENCLAD
`
`PATIENTS
`ON PLACEBO
`
`38%
`
`32%
`
`https://web.archive.orghweb/20231 004232146/https:/Avww.mavenclad.com/en/home/why-mavenclad/safety-and-side-effects.html
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`5/15
`
`
`
`
`
`Common side effects seen in clinical trials
`-.//.0ÿ2345ÿ5665782ÿ2550ÿ30ÿ793037:9ÿ8;3:92
`
`Someof the most commonside effects experienced by patients included:
`<=>?ÿ=AÿBC?ÿ>=DBÿE=>>=FÿDGH?ÿ?AA?EBDÿ?IJ?KG?FE?HÿLMÿJNBG?FBDÿGFEOPH?HQ
`
`UPPER RESPIRATORY INFECTION
`
`PATIENTS
`ON MAVENCLAD
`
`PATIENTS
`ON PLACEBO
`
`38%
`
`32%
`
`https://web.archive.orghweb/20231 004232146/https:/Avww.mavenclad.com/en/home/why-mavenclad/safety-and-side-effects.html
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`5/15
`
`
`
`
`
`12/19/23, 6:59 PM
` ÿ ÿ
`
`
`Side Effects & Safety Info | Mavenclad® (cladribine) Tablets
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`
`
`HEADACHE
`
`PATIENTS
`ON MAVENCLAD
`
`PATIENTS
`ON PLACEBO
`
`25%
`
`19%
`
`https://web.archive.orghweb/20231 004232146/https:/Avww.mavenclad.com/en/home/why-mavenclad/safety-and-side-effects.html
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`6/15
`
`
`
`
`
`
`HEADACHE
`
`PATIENTS
`ON MAVENCLAD
`
`PATIENTS
`ON PLACEBO
`
`25%
`
`19%
`
`https://web.archive.orghweb/20231 004232146/https:/Avww.mavenclad.com/en/home/why-mavenclad/safety-and-side-effects.html
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`6/15
`
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`ÿ /
`
`011ÿ3456ÿ748946ÿ:46ÿ;<7=801ÿ07>=8<ÿ0?459ÿ@=7<ÿ<::<89@AÿB45ÿ;03ÿ6<C469ÿ@=7<ÿ<::<89@ÿ94ÿDEFÿ09ÿGHIJJHKLMH
`
`GJIIA
`
`D46ÿ;46<ÿ=N:46;09=4NOÿC1<0@<ÿ@<<ÿ9P<ÿ077=9=4N01ÿRSTUVWXYWÿZX[\W]ÿRY[UVSXW^UYOÿ:511ÿ_M`abcdML
`
`eV\fgV^h^YiÿRY[UVSXW^UYjÿ0N7ÿ_\k^gXW^UYÿlm^k\n
`
`ÿ
`
`p ÿ+ÿ %%
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`-
`
`
`
`ÿ /
`
`011ÿ3456ÿ748946ÿ:46ÿ;<7=801ÿ07>=8<ÿ0?459ÿ@=7<ÿ<::<89@AÿB45ÿ;03ÿ6<C469ÿ@=7<ÿ<::<89@ÿ94ÿDEFÿ09ÿGHIJJHKLMH
`
`GJIIA
`
`D46ÿ;46<ÿ=N:46;09=4NOÿC1<0@<ÿ@<<ÿ9P<ÿ077=9=4N01ÿRSTUVWXYWÿZX[\W]ÿRY[UVSXW^UYOÿ:511ÿ_M`abcdML
`
`eV\fgV^h^YiÿRY[UVSXW^UYjÿ0N7ÿ_\k^gXW^UYÿlm^k\n
`
`ÿ
`
`p ÿ+ÿ %%
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`-
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`9A>7AÿADEÿFG.HE79>AIG.
`
`JKKLÿNKOPÿQROSTUVÿQWÿXWYZÿLW[QWZÿR\WYQÿ]QRZQTUVÿ^_`aJbc_deÿbNK[SÿWYQÿQNKÿdW[QWZÿdT][Y]]TWUÿfYTLKÿgWZ
`QROSTUVÿPWTUQ]ÿRULÿNKOPgYOÿQTP]h
`
`lGi.kG>lÿADEÿ3l{
`
`./01ÿ345/6ÿ7/48ÿ91:;</=ÿ>?:@1ÿA;/41B/C1
`
`iD>AÿI9ÿj>HE.Fk>lm
`
`^_`aJbc_dÿT]ÿRÿPZK][ZTPQTWUÿnKLT[TUKÿY]KLÿQWÿQZKRQÿZKORP]TUVÿgWZn]ÿWgÿnYOQTPOKÿ][OKZW]T]ÿo^pqrÿQWÿTU[OYLK
`ZKORP]TUVsZKnTQQTUVÿLT]KR]KÿRULÿR[QTtKÿ]K[WULRZXÿPZWVZK]]TtKÿLT]KR]KrÿTUÿRLYOQ]hÿuK[RY]KÿWgÿTQ]ÿ]RgKQX
`PZWvOKrÿ^_`aJbc_dÿT]ÿVKUKZROOXÿY]KLÿTUÿPKWPOKÿwNWÿNRtKÿQZTKLÿRUWQNKZÿ^pÿnKLT[TUKÿQNRQÿQNKXÿ[WYOLÿUWQ
`QWOKZRQKÿWZÿQNRQÿNR]ÿUWQÿwWZSKLÿwKOOÿKUWYVNh
`
`^_`aJbc_dÿT]ÿUWQÿZK[WnnKULKLÿgWZÿY]KÿTUÿPKWPOKÿwTQNÿ[OTUT[ROOXÿT]WORQKLÿ]XULZWnKÿobxpqh
`
`xQÿT]ÿUWQÿSUWwUÿTgÿ^_`aJbc_dÿT]ÿ]RgKÿRULÿKggK[QTtKÿTUÿ[NTOLZKUÿYULKZÿyzÿXKRZ]ÿWgÿRVKrÿRULÿT]ÿQNKZKgWZKÿUWQ
`ZK[WnnKULKLh
`
`Ij3G7A>.Aÿ9>{EA|ÿI.{G7j>AIG.
`
`j>HE.Fk>lÿB4}ÿ~4@=/ÿ=/;<:@=ÿ=</ÿ//~1=ÿ<C~8@<C56
`
`7<=ÿ:ÿ~4C~/;ÿB48<5C4C~</= ÿWYÿ]NWYOLÿgWOOWwÿNKROQN[RZKÿPZWtTLKZÿTU]QZY[QTWU]ÿR\WYQÿ][ZKKUTUVÿgWZ
`[RU[KZh
`
`j>HE.Fk>lÿB4}ÿ~4@=/ÿ?<;1ÿ//~1=ÿ<ÿ@=/ÿ@;<C5ÿ;/5C4C~} ÿ{/B48/=ÿB@=1ÿC:1ÿ?/ÿ;/5C4C1ÿ/C
`1/}ÿ=14;1ÿ1;/41B/C1ÿ<1ÿj>HE.Fk>lÿ:;ÿ?/~:B/ÿ;/5C4C1ÿ@;<C5ÿj>HE.Fk>lÿ:=<C5ÿ4Cÿ<1<Cÿ
`B:C1=ÿ41/;ÿ1/ÿ84=1ÿ:=/ÿ:ÿ/4~ÿ}/4;8}ÿ1;/41B/C1ÿ~:@;=/ ÿ|:@ÿ=:@8ÿ=1:ÿ1;/41B/C1ÿ<1
`j>HE.Fk>lÿ4Cÿ~:C14~1ÿ}:@;ÿ/481~4;/ÿ;:</;ÿ;<51ÿ44}ÿ<ÿ}:@ÿ?/~:B/ÿ;/5C4C1ÿ@;<C5
`1;/41B/C1ÿ<1ÿj>HE.Fk>l
`WZÿgKnROK]ÿwNWÿRZKÿR\OKÿQWÿ\K[WnKÿPZKVURUQ
`WYZÿNKROQN[RZKÿPZWtTLKZÿ]NWYOLÿWZLKZÿRÿPZKVURU[XÿQK]Qÿ\KgWZKÿXWYÿ\KVTUÿXWYZÿvZ]QÿRULÿ]K[WUL
`XKRZOXÿQZKRQnKUQÿ[WYZ]KÿWgÿ^_`aJbc_dÿQWÿnRSKÿ]YZKÿQNRQÿXWYÿRZKÿUWQÿPZKVURUQh
`
`]KÿKggK[QTtKÿ\TZQNÿ[WUQZWOÿo[WUQZR[KPQTWUqÿWUÿQNKÿLRX]ÿWUÿwNT[NÿXWYÿQRSKÿ^_`aJbc_dÿRULÿgWZ
`RQÿOKR]QÿÿnWUQN]ÿRgQKZÿQNKÿOR]QÿLW]KÿWgÿKR[NÿXKRZOXÿQZKRQnKUQÿ[WYZ]Kh
`ROSÿQWÿXWYZÿNKROQN[RZKÿPZWtTLKZÿTgÿXWYÿY]KÿWZROÿ[WUQZR[KPQTtK]ÿoQNKÿPTOOqh
`
`WYÿ]NWYOLÿY]KÿRÿ]K[WULÿnKQNWLÿWgÿ\TZQNÿ[WUQZWOÿWUÿQNKÿLRX]ÿWUÿwNT[NÿXWYÿQRSKÿ^_`aJbc_d
`RULÿgWZÿRQÿOKR]QÿÿwKKS]ÿRgQKZÿXWYZÿOR]QÿLW]KÿWgÿKR[NÿXKRZOXÿQZKRQnKUQÿ[WYZ]Kh
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`-
`
`
`
`9A>7AÿADEÿFG.HE79>AIG.
`
`JKKLÿNKOPÿQROSTUVÿQWÿXWYZÿLW[QWZÿR\WYQÿ]QRZQTUVÿ^_`aJbc_deÿbNK[SÿWYQÿQNKÿdW[QWZÿdT][Y]]TWUÿfYTLKÿgWZ
`QROSTUVÿPWTUQ]ÿRULÿNKOPgYOÿQTP]h
`
`lGi.kG>lÿADEÿ3l{
`
`./01ÿ345/6ÿ7/48ÿ91:;</=ÿ>?:@1ÿA;/41B/C1
`
`iD>AÿI9ÿj>HE.Fk>lm
`
`^_`aJbc_dÿT]ÿRÿPZK][ZTPQTWUÿnKLT[TUKÿY]KLÿQWÿQZKRQÿZKORP]TUVÿgWZn]ÿWgÿnYOQTPOKÿ][OKZW]T]ÿo^pqrÿQWÿTU[OYLK
`ZKORP]TUVsZKnTQQTUVÿLT]KR]KÿRULÿR[QTtKÿ]K[WULRZXÿPZWVZK]]TtKÿLT]KR]KrÿTUÿRLYOQ]hÿuK[RY]KÿWgÿTQ]ÿ]RgKQX
`PZWvOKrÿ^_`aJbc_dÿT]ÿVKUKZROOXÿY]KLÿTUÿPKWPOKÿwNWÿNRtKÿQZTKLÿRUWQNKZÿ^pÿnKLT[TUKÿQNRQÿQNKXÿ[WYOLÿUWQ
`QWOKZRQKÿWZÿQNRQÿNR]ÿUWQÿwWZSKLÿwKOOÿKUWYVNh
`
`^_`aJbc_dÿT]ÿUWQÿZK[WnnKULKLÿgWZÿY]KÿTUÿPKWPOKÿwTQNÿ[OTUT[ROOXÿT]WORQKLÿ]XULZWnKÿobxpqh
`
`xQÿT]ÿUWQÿSUWwUÿTgÿ^_`aJbc_dÿT]ÿ]RgKÿRULÿKggK[QTtKÿTUÿ[NTOLZKUÿYULKZÿyzÿXKRZ]ÿWgÿRVKrÿRULÿT]ÿQNKZKgWZKÿUWQ
`ZK[WnnKULKLh
`
`Ij3G7A>.Aÿ9>{EA|ÿI.{G7j>AIG.
`
`j>HE.Fk>lÿB4}ÿ~4@=/ÿ=/;<:@=ÿ=</ÿ//~1=ÿ<C~8@<C56
`
`7<=ÿ:ÿ~4C~/;ÿB48<5C4C~</= ÿWYÿ]NWYOLÿgWOOWwÿNKROQN[RZKÿPZWtTLKZÿTU]QZY[QTWU]ÿR\WYQÿ][ZKKUTUVÿgWZ
`[RU[KZh
`
`j>HE.Fk>lÿB4}ÿ~4@=/ÿ?<;1ÿ//~1=ÿ<ÿ@=/ÿ@;<C5ÿ;/5C4C~} ÿ{/B48/=ÿB@=1ÿC:1ÿ?/ÿ;/5C4C1ÿ/C
`1/}ÿ=14;1ÿ1;/41B/C1ÿ<1ÿj>HE.Fk>lÿ:;ÿ?/~:B/ÿ;/5C4C1ÿ@;<C5ÿj>HE.Fk>lÿ:=<C5ÿ4Cÿ<1<Cÿ
`B:C1=ÿ41/;ÿ1/ÿ84=1ÿ:=/ÿ:ÿ/4~ÿ}/4;8}ÿ1;/41B/C1ÿ~:@;=/ ÿ|:@ÿ=:@8ÿ=1:ÿ1;/41B/C1ÿ<1
`j>HE.Fk>lÿ4Cÿ~:C14~1ÿ}:@;ÿ/481~4;/ÿ;:</;ÿ;<51ÿ44}ÿ<ÿ}:@ÿ?/~:B/ÿ;/5C4C1ÿ@;<C5
`1;/41B/C1ÿ<1ÿj>HE.Fk>l
`WZÿgKnROK]ÿwNWÿRZKÿR\OKÿQWÿ\K[WnKÿPZKVURUQ
`WYZÿNKROQN[RZKÿPZWtTLKZÿ]NWYOLÿWZLKZÿRÿPZKVURU[XÿQK]Qÿ\KgWZKÿXWYÿ\KVTUÿXWYZÿvZ]QÿRULÿ]K[WUL
`XKRZOXÿQZKRQnKUQÿ[WYZ]KÿWgÿ^_`aJbc_dÿQWÿnRSKÿ]YZKÿQNRQÿXWYÿRZKÿUWQÿPZKVURUQh
`
`]KÿKggK[QTtKÿ\TZQNÿ[WUQZWOÿo[WUQZR[KPQTWUqÿWUÿQNKÿLRX]ÿWUÿwNT[NÿXWYÿQRSKÿ^_`aJbc_dÿRULÿgWZ
`RQÿOKR]QÿÿnWUQN]ÿRgQKZÿQNKÿOR]QÿLW]KÿWgÿKR[NÿXKRZOXÿQZKRQnKUQÿ[WYZ]Kh
`ROSÿQWÿXWYZÿNKROQN[RZKÿPZWtTLKZÿTgÿXWYÿY]KÿWZROÿ[WUQZR[KPQTtK]ÿoQNKÿPTOOqh
`
`WYÿ]NWYOLÿY]KÿRÿ]K[WULÿnKQNWLÿWgÿ\TZQNÿ[WUQZWOÿWUÿQNKÿLRX]ÿWUÿwNT[NÿXWYÿQRSKÿ^_`aJbc_d
`RULÿgWZÿRQÿOKR]QÿÿwKKS]ÿRgQKZÿXWYZÿOR]QÿLW]KÿWgÿKR[NÿXKRZOXÿQZKRQnKUQÿ[WYZ]Kh
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`-
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`-./ÿ12345ÿ6789ÿ:41234ÿ;2/8<4/5ÿ69.ÿ2/4ÿ2=34ÿ8.ÿ=4>.14ÿ;/4?<2<8@
`A54ÿ4::4>87B4ÿ=7/89ÿ>.<8/.3ÿC>.<8/2>4;87.<DÿEF/7<?ÿ894ÿE2G5ÿ.<ÿ697>9ÿG.Fÿ82H4ÿIJKLMNOJPÿ2<E
`:./ÿ28ÿ34258ÿQÿ1.<895ÿ2:84/ÿ894ÿ3258ÿE.54ÿ.:ÿ42>9ÿG42/3Gÿ8/42814<8ÿ>.F/54R
`STÿVTWÿ82H4ÿIJKLMNOJPÿ7:ÿG.F@
`
`92B4ÿ>2<>4/ÿC1237?<2<>GDR
`
`2/4ÿ;/4?<2<8Yÿ;32<ÿ8.ÿ=4>.14ÿ;/4?<2<8Yÿ./ÿ2/4ÿ2ÿ6.12<ÿ.:ÿ>973E=42/7<?ÿ2?4ÿ./ÿ2ÿ12<ÿ2=34ÿ8.ÿ:2894/ÿ2
`>973Eÿ2<EÿG.Fÿ2/4ÿ<.8ÿF57<?ÿ=7/89ÿ>.<8/.3R
`
`2/4ÿ=/4258:44E7<?R
`
`2/4ÿ9F12<ÿ711F<.E4Z>74<>GÿB7/F5ÿC[\KDÿ;.5787B4R
`
`92B4ÿ2>87B4ÿ7<:4>87.<5Yÿ7<>3FE7<?ÿ8F=4/>F3.575ÿC]^DYÿ94;287875ÿ^ÿ./ÿNR
`
`2/4ÿ2334/?7>ÿ8.ÿ>32E/7=7<4R
`
`_`aTb`ÿcTdÿWef`ÿghijklmhSnÿW`ooÿcTdbÿp`eoWpqeb`ÿrbTstu`bÿevTdWÿeooÿTaÿcTdbÿw`utqeoÿqTVutWtTVxnÿtVqodutVy
`taÿcTd@
`
`897<HÿG.Fÿ92B4ÿ2<ÿ7<:4>87.<R
`
`92B4ÿ82H4<Yÿ82H4Yÿ./ÿ;32<ÿ8.ÿ82H4ÿ14E7>7<45ÿ8928ÿ2::4>8ÿG.F/ÿ711F<4ÿ5G5841ÿ./ÿ=3..Eÿ>4335Yÿ./ÿ.894/
`8/42814<85ÿ:./ÿIzRÿN4/827<ÿ14E7>7<45ÿ>2<ÿ7<>/4254ÿG.F/ÿ/75Hÿ.:ÿ?4887<?ÿ2<ÿ7<:4>87.<R
`
`92B4ÿ92Eÿ2ÿ/4>4<8ÿB2>>7<287.<ÿ./ÿ2/4ÿ5>94EF34Eÿ8.ÿ/4>47B4ÿ2<GÿB2>>7<287.<5Rÿ{.Fÿ59.F3Eÿ<.8ÿ/4>47B4
`37B4ÿ./ÿ37B4|2884<F284EÿB2>>7<45ÿ67897<ÿ894ÿ}ÿ8.ÿQÿ644H5ÿ;/4>4E7<?ÿ8/42814<8ÿ6789ÿIJKLMNOJPÿ./
`/4>47B4ÿ89454ÿ8G;45ÿ.:ÿB2>>7<45ÿEF/7<?ÿG.F/ÿ8/42814<8ÿ6789ÿIJKLMNOJPÿ2<EÿF<3455ÿE7/4>84Eÿ=GÿG.F/
`942389>2/4ÿ;/.B7E4/R
`
`92B4ÿ942/8ÿ:273F/4R
`
`92B4ÿ./ÿ92B4ÿ92Eÿ>2<>4/R
`
`92B4ÿ37B4/ÿ./ÿH7E<4Gÿ;/.=3415R
`
`2/4ÿ=/4258:44E7<?ÿ./ÿ;32<ÿ8.ÿ=/4258:44ERÿ\8ÿ75ÿ<.8ÿH<.6<ÿ7:ÿIJKLMNOJPÿ;25545ÿ7<8.ÿG.F/ÿ=/4258ÿ173HRÿP.
`<.8ÿ=/4258:44Eÿ.<ÿ894ÿE2G5ÿ.<ÿ697>9ÿG.Fÿ82H4ÿIJKLMNOJPYÿ2<Eÿ:./ÿ~ÿE2G5ÿ2:84/ÿ894ÿ3258ÿE.54R
`
`TÿxpTdouÿÿWef`ÿghijklmhS
`
`IJKLMNOJPÿ75ÿ?7B4<ÿ25ÿ86.ÿG42/3Gÿ8/42814<8ÿ>.F/545R
`
`L2>9ÿG42/3Gÿ8/42814<8ÿ>.F/54ÿ>.<57585ÿ.:ÿÿ8/42814<8ÿ644H5ÿC235.ÿ>2334Eÿ>G>345Dÿ8928ÿ6733ÿ=4ÿ2=.F8ÿ2
`1.<89ÿ2;2/8R
`
`]2H4ÿIJKLMNOJPÿ6789ÿ6284/ÿ2<Eÿ56233.6ÿ69.34ÿ6789.F8ÿ>9467<?RÿIJKLMNOJPÿ>2<ÿ=4ÿ82H4<ÿ6789ÿ./
`6789.F8ÿ:..ER
`
`z6233.6ÿIJKLMNOJPÿ/7?98ÿ262Gÿ2:84/ÿ.;4<7<?ÿ894ÿ=37584/ÿ;2>HR
`
`{.F/ÿ92<E5ÿ1F58ÿ=4ÿE/Gÿ694<ÿ92<E37<?ÿIJKLMNOJPÿ2<Eÿ62594Eÿ6433ÿ6789ÿ6284/ÿ2:84/62/E5R
`
`O7178ÿ>.<82>8ÿ6789ÿG.F/ÿ5H7<RÿJB.7Eÿ8.F>97<?ÿG.F/ÿ<.54Yÿ4G45ÿ2<Eÿ.894/ÿ;2/85ÿ.:ÿ894ÿ=.EGRÿ\:ÿG.Fÿ?48
`IJKLMNOJPÿ.<ÿG.F/ÿ5H7<ÿ./ÿ.<ÿ2<Gÿ5F/:2>4Yÿ6259ÿ78ÿ/7?98ÿ262Gÿ6789ÿ6284/R
`
`]2H4ÿIJKLMNOJPÿ28ÿ34258ÿ ÿ9.F/5ÿ2;2/8ÿ:/.1ÿ.894/ÿ14E7>7<45ÿ82H4<ÿ=Gÿ1.F89ÿEF/7<?ÿ894ÿ}|ÿ8.ÿ|E2G
`IJKLMNOJPÿ8/42814<8ÿ644HR
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
`-./ÿ12345ÿ6789ÿ:41234ÿ;2/8<4/5ÿ69.ÿ2/4ÿ2=34ÿ8.ÿ=4>.14ÿ;/4?<2<8@
`A54ÿ4::4>87B4ÿ=7/89ÿ>.<8/.3ÿC>.<8/2>4;87.<DÿEF/7<?ÿ894ÿE2G5ÿ.<ÿ697>9ÿG.Fÿ82H4ÿIJKLMNOJPÿ2<E
`:./ÿ28ÿ34258ÿQÿ1.<895ÿ2:84/ÿ894ÿ3258ÿE.54ÿ.:ÿ42>9ÿG42/3Gÿ8/42814<8ÿ>.F/54R
`STÿVTWÿ82H4ÿIJKLMNOJPÿ7:ÿG.F@
`
`92B4ÿ>2<>4/ÿC1237?<2<>GDR
`
`2/4ÿ;/4?<2<8Yÿ;32<ÿ8.ÿ=4>.14ÿ;/4?<2<8Yÿ./ÿ2/4ÿ2ÿ6.12<ÿ.:ÿ>973E=42/7<?ÿ2?4ÿ./ÿ2ÿ12<ÿ2=34ÿ8.ÿ:2894/ÿ2
`>973Eÿ2<EÿG.Fÿ2/4ÿ<.8ÿF57<?ÿ=7/89ÿ>.<8/.3R
`
`2/4ÿ=/4258:44E7<?R
`
`2/4ÿ9F12<ÿ711F<.E4Z>74<>GÿB7/F5ÿC[\KDÿ;.5787B4R
`
`92B4ÿ2>87B4ÿ7<:4>87.<5Yÿ7<>3FE7<?ÿ8F=4/>F3.575ÿC]^DYÿ94;287875ÿ^ÿ./ÿNR
`
`2/4ÿ2334/?7>ÿ8.ÿ>32E/7=7<4R
`
`_`aTb`ÿcTdÿWef`ÿghijklmhSnÿW`ooÿcTdbÿp`eoWpqeb`ÿrbTstu`bÿevTdWÿeooÿTaÿcTdbÿw`utqeoÿqTVutWtTVxnÿtVqodutVy
`taÿcTd@
`
`897<HÿG.Fÿ92B4ÿ2<ÿ7<:4>87.<R
`
`92B4ÿ82H4<Yÿ82H4Yÿ./ÿ;32<ÿ8.ÿ82H4ÿ14E7>7<45ÿ8928ÿ2::4>8ÿG.F/ÿ711F<4ÿ5G5841ÿ./ÿ=3..Eÿ>4335Yÿ./ÿ.894/
`8/42814<85ÿ:./ÿIzRÿN4/827<ÿ14E7>7<45ÿ>2<ÿ7<>/4254ÿG.F/ÿ/75Hÿ.:ÿ?4887<?ÿ2<ÿ7<:4>87.<R
`
`92B4ÿ92Eÿ2ÿ/4>4<8ÿB2>>7<287.<ÿ./ÿ2/4ÿ5>94EF34Eÿ8.ÿ/4>47B4ÿ2<GÿB2>>7<287.<5Rÿ{.Fÿ59.F3Eÿ<.8ÿ/4>47B4
`37B4ÿ./ÿ37B4|2884<F284EÿB2>>7<45ÿ67897<ÿ894ÿ}ÿ8.ÿQÿ644H5ÿ;/4>4E7<?ÿ8/42814<8ÿ6789ÿIJKLMNOJPÿ./
`/4>47B4ÿ89454ÿ8G;45ÿ.:ÿB2>>7<45ÿEF/7<?ÿG.F/ÿ8/42814<8ÿ6789ÿIJKLMNOJPÿ2<EÿF<3455ÿE7/4>84Eÿ=GÿG.F/
`942389>2/4ÿ;/.B7E4/R
`
`92B4ÿ942/8ÿ:273F/4R
`
`92B4ÿ./ÿ92B4ÿ92Eÿ>2<>4/R
`
`92B4ÿ37B4/ÿ./ÿH7E<4Gÿ;/.=3415R
`
`2/4ÿ=/4258:44E7<?ÿ./ÿ;32<ÿ8.ÿ=/4258:44ERÿ\8ÿ75ÿ<.8ÿH<.6<ÿ7:ÿIJKLMNOJPÿ;25545ÿ7<8.ÿG.F/ÿ=/4258ÿ173HRÿP.
`<.8ÿ=/4258:44Eÿ.<ÿ894ÿE2G5ÿ.<ÿ697>9ÿG.Fÿ82H4ÿIJKLMNOJPYÿ2<Eÿ:./ÿ~ÿE2G5ÿ2:84/ÿ894ÿ3258ÿE.54R
`
`TÿxpTdouÿÿWef`ÿghijklmhS
`
`IJKLMNOJPÿ75ÿ?7B4<ÿ25ÿ86.ÿG42/3Gÿ8/42814<8ÿ>.F/545R
`
`L2>9ÿG42/3Gÿ8/42814<8ÿ>.F/54ÿ>.<57585ÿ.:ÿÿ8/42814<8ÿ644H5ÿC235.ÿ>2334Eÿ>G>345Dÿ8928ÿ6733ÿ=4ÿ2=.F8ÿ2
`1.<89ÿ2;2/8R
`
`]2H4ÿIJKLMNOJPÿ6789ÿ6284/ÿ2<Eÿ56233.6ÿ69.34ÿ6789.F8ÿ>9467<?RÿIJKLMNOJPÿ>2<ÿ=4ÿ82H4<ÿ6789ÿ./
`6789.F8ÿ:..ER
`
`z6233.6ÿIJKLMNOJPÿ/7?98ÿ262Gÿ2:84/ÿ.;4<7<?ÿ894ÿ=37584/ÿ;2>HR
`
`{.F/ÿ92<E5ÿ1F58ÿ=4ÿE/Gÿ694<ÿ92<E37<?ÿIJKLMNOJPÿ2<Eÿ62594Eÿ6433ÿ6789ÿ6284/ÿ2:84/62/E5R
`
`O7178ÿ>.<82>8ÿ6789ÿG.F/ÿ5H7<RÿJB.7Eÿ8.F>97<?ÿG.F/ÿ<.54Yÿ4G45ÿ2<Eÿ.894/ÿ;2/85ÿ.:ÿ894ÿ=.EGRÿ\:ÿG.Fÿ?48
`IJKLMNOJPÿ.<ÿG.F/ÿ5H7<ÿ./ÿ.<ÿ2<Gÿ5F/:2>4Yÿ6259ÿ78ÿ/7?98ÿ262Gÿ6789ÿ6284/R
`
`]2H4ÿIJKLMNOJPÿ28ÿ34258ÿ ÿ9.F/5ÿ2;2/8ÿ:/.1ÿ.894/ÿ14E7>7<45ÿ82H4<ÿ=Gÿ1.F89ÿEF/7<?ÿ894ÿ}|ÿ8.ÿ|E2G
`IJKLMNOJPÿ8/42814<8ÿ644HR
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`-.ÿ012ÿ3455ÿ6ÿ71589ÿ:6;8ÿ4:ÿ65ÿ511<ÿ65ÿ012ÿ=8383>8=ÿ1<ÿ:?8ÿ5638ÿ760@ÿ-.ÿ:?8ÿA?1B8ÿ760ÿC65585ÿ>8.1=8
`
`012ÿ=8383>8=9ÿ:6;8ÿ012=ÿ345587ÿ7158ÿ:?8ÿ<8D:ÿ760@ÿE1ÿ<1:ÿ:6;8ÿFÿ71585ÿ6:ÿ:?8ÿ5638ÿ:438@ÿ-<5:8679ÿ012
`
`A4BBÿ8D:8<7ÿ:?8ÿ<23>8=ÿ1.ÿ7605ÿ4<ÿ:?6:ÿ:=86:38<:ÿA88;@
`
`G12=ÿ?86B:?H6=8ÿC=1I478=ÿA4BBÿH1<:4<28ÿ:1ÿ31<4:1=ÿ012=ÿ?86B:?ÿ72=4<Jÿ:?8ÿFÿ086=B0ÿ:=86:38<:ÿH12=5859ÿ6<7ÿ.1=
`6:ÿB865:ÿ6<1:?8=ÿFÿ086=5ÿ72=4<JÿA?4H?ÿ012ÿ71ÿ<1:ÿ<887ÿ:1ÿ:6;8ÿKLMNOPQLE@ÿ-:ÿ45ÿ<1:ÿ;<1A<ÿ4.ÿKLMNOPQLE
`45ÿ56.8ÿ6<7ÿ8..8H:4I8ÿ4<ÿC81CB8ÿA?1ÿ=85:6=:ÿKLMNOPQLEÿ:=86:38<:ÿ31=8ÿ:?6<ÿFÿ086=5ÿ6.:8=ÿH13CB8:4<JÿF
`086=B0ÿ:=86:38<:ÿH12=585@
`
`RSTUVWXSYÿ[\]ÿ[\^_`ÿ_`abc^_ÿ_bd`ÿ`ee`[f_gÿheÿic^ÿj\k`ÿ\]iÿceÿfj`_`ÿ_ilmfcl_ÿnb_f`dÿo`ncpqÿ[\nnÿic^a
`j`\nfj[\a`ÿmackbd`aÿabrjfÿ\p\is
`
`ncpÿonccdÿ[`nnÿ[c^]f_ÿ?6I8ÿ?6CC8<87ÿ6<7ÿH6<ÿ4<H=8658ÿ012=ÿ=45;ÿ1.ÿ4<.8H:41<5ÿ72=4<Jÿ:=86:38<:ÿA4:?
`KLMNOPQLE@ÿtB117ÿ:85:5ÿ6=8ÿ<88787ÿ>8.1=8ÿ012ÿ5:6=:ÿ:=86:38<:ÿA4:?ÿKLMNOPQLE9ÿ72=4<Jÿ012=
`:=86:38<:ÿA4:?ÿKLMNOPQLE9ÿ6<7ÿ6.:8=A6=79ÿ65ÿ<88787@
`
`_`abc^_ÿb]e`[fbc]_ÿ_^[jÿ\_s
`uvqÿj`m\fbfb_ÿvÿcaÿWqÿ\]dÿ_jb]rn`_ÿwj`am`_ÿxc_f`aygÿz6:6BÿH6585ÿ1.ÿ{tÿ6<7ÿ?8C6:4:45ÿ?6I8ÿ?6CC8<87
`A4:?ÿHB67=4>4<8ÿ72=4<JÿHB4<4H6Bÿ5:27485@ÿ{8BBÿ012=ÿ?86B:?H6=8ÿC=1I478=ÿ=4J?:ÿ6A60ÿ4.ÿ012ÿJ8:ÿ6<0
`503C:135ÿ1.ÿ:?8ÿ.1BB1A4<Jÿ4<.8H:41<ÿ=8B6:87ÿC=1>B835ÿ1=ÿ4.ÿ6<0ÿ1.ÿ:?8ÿ503C:135ÿJ8:ÿA1=589ÿ4<HB274<J|
`.8I8=9ÿ6H?4<JÿC64<.2Bÿ325HB859ÿ?8676H?89ÿ.88B4<Jÿ1.ÿ>84<JÿJ8<8=6BB0ÿ2<A8BB9ÿB155ÿ1.ÿ6CC8:4:89ÿ>2=<4<J9
`:4<JB4<J9ÿ<23><855ÿ1=ÿ4:H?4<855ÿ1.ÿ:?8ÿ5;4<ÿ4<ÿ:?8ÿ6..8H:87ÿ6=869ÿ5;4<ÿ>B1:H?859ÿ>B45:8=87ÿ=65?9ÿ1=
`58I8=8ÿC64<@
`
`macra`__bk`ÿl^nfbec[\nÿn`^}c`][`mj\ncm\fjiÿw~RXygÿKQÿ45ÿ6ÿ=6=8ÿ>=64<ÿ4<.8H:41<ÿ:?6:ÿ2526BB0ÿB8675
`:1ÿ786:?ÿ1=ÿ58I8=8ÿ7456>4B4:0@ÿLB:?12J?ÿKQÿ?65ÿ<1:ÿ>88<ÿ588<ÿ4<ÿKÿC6:48<:5ÿ:6;4<JÿKLMNOPQLE9ÿ4:
`360ÿ?6CC8<ÿ4<ÿC81CB8ÿA4:?ÿA86;8<87ÿ4332<8ÿ505:835@ÿ{8BBÿ012=ÿ?86B:?H6=8ÿC=1I478=ÿ=4J?:ÿ6A60ÿ4.
`012ÿ?6I8ÿ6<0ÿ<8Aÿ1=ÿA1=58<4<Jÿ<82=1B1J4Hÿ54J<5ÿ1=ÿ503C:135@ÿ{?858ÿ360ÿ4<HB278|ÿA86;<855ÿ1<ÿ
`5478ÿ1.ÿ012=ÿ>1709ÿB155ÿ1.ÿH11=74<6:41<ÿ4<ÿ012=ÿ6=35ÿ6<7ÿB8J59ÿ78H=86587ÿ5:=8<J:?9ÿC=1>B835ÿA4:?
`>6B6<H89ÿH?6<J85ÿ4<ÿ012=ÿI4541<9ÿH?6<J85ÿ4<ÿ012=ÿ:?4<;4<Jÿ1=ÿ3831=09ÿH1<.2541<9ÿ1=ÿH?6<J85ÿ4<ÿ012=
`C8=51<6B4:0@
`
`nbk`aÿmacon`l_@ÿtB117ÿ:85:5ÿ5?12B7ÿ>8ÿC8=.1=387ÿ:1ÿH?8H;ÿ012=ÿB4I8=ÿ>8.1=8ÿ012ÿ5:6=:ÿ:6;4<J
`KLMNOPQLE@ÿ03C:135ÿ1.ÿB4I8=ÿC=1>B835ÿ360ÿ4<HB278|ÿ<625869ÿI134:4<J9ÿ5:136H?ÿC64<9ÿ:4=87<8559ÿB155
`1.ÿ6CC8:4:89ÿ76=;ÿ2=4<89ÿ1=ÿ012=ÿ5;4<ÿ1=ÿ:?8ÿA?4:85ÿ1.ÿ012=ÿ8085ÿ:2=<ÿ08BB1A@
`
`\nn`arb[ÿa`\[fbc]_ÿwjim`a_`]_bfbkbfb`_ygÿG12ÿ5?12B7ÿ5:1Cÿ:=86:38<:ÿ6<7ÿ588;ÿ4338746:8ÿ3874H6B
`6::8<:41<ÿ4.ÿ6<0ÿ54J<5ÿ1=ÿ503C:135ÿ1.ÿ6BB8=J4Hÿ=86H:41<5ÿ1HH2=@ÿ03C:135ÿ1.ÿ6<ÿ6BB8=J4Hÿ=86H:41<ÿ360
`4<HB278|ÿ5;4<ÿ=65?9ÿ5A8BB4<Jÿ1=ÿ4:H?4<Jÿ1.ÿ:?8ÿ.6H89ÿB4C59ÿ:1<J28ÿ1=ÿ:?=16:9ÿ1=ÿ:=12>B8ÿ>=86:?4<J@
`
`j`\afÿe\bn^a`gÿKLMNOPQLEÿ360ÿH6258ÿ?86=:ÿ.64B2=89ÿA?4H?ÿ386<5ÿ012=ÿ?86=:ÿ360ÿ<1:ÿC23Cÿ65ÿA8BBÿ65ÿ4:
`5?12B7@ÿP6BBÿ012=ÿ?86B:?H6=8ÿC=1I478=ÿ1=ÿJ1ÿ:1ÿ:?8ÿHB1585:ÿ838=J8<H0ÿ=113ÿ.1=ÿ3874H6Bÿ?8BCÿ=4J?:ÿ6A60
`4.ÿ012ÿ?6I8ÿ6<0ÿ54J<5ÿ1=ÿ503C:135ÿ52H?ÿ65ÿ5?1=:<855ÿ1.ÿ>=86:?9ÿ6ÿ.65:ÿ1=ÿ4==8J2B6=ÿ?86=:ÿ>86:9ÿ1=ÿ2<2526B
`5A8BB4<Jÿ4<ÿ012=ÿ>170@
`
`uj`ÿlc_fÿ[cllc]ÿ_bd`ÿ`ee`[f_ÿceÿRSTUVWXSYÿb][n^d`sÿ2CC8=ÿ=85C4=6:1=0ÿ4<.8H:41<9ÿ?8676H?89ÿ6<7ÿB1A
`A?4:8ÿ>B117ÿH8BBÿH12<:5@
`
`{?858ÿ6=8ÿ<1:ÿ6BBÿ:?8ÿC1554>B8ÿ5478ÿ8..8H:5ÿ1.ÿKLMNOPQLE@ÿP6BBÿ012=ÿ71H:1=ÿ.1=ÿ3874H6Bÿ67I4H8ÿ6>12:ÿ5478
`8..8H:5@ÿG12ÿ360ÿ=8C1=:ÿ5478ÿ8..8H:5ÿ:1ÿzELÿ6:ÿ YS g
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
` )
`
`
`
`-.ÿ012ÿ3455ÿ6ÿ71589ÿ:6;8ÿ4:ÿ65ÿ511<ÿ65ÿ012ÿ=8383>8=ÿ1<ÿ:?8ÿ5638ÿ760@ÿ-.ÿ:?8ÿA?1B8ÿ760ÿC65585ÿ>8.1=8
`
`012ÿ=8383>8=9ÿ:6;8ÿ012=ÿ345587ÿ7158ÿ:?8ÿ<8D:ÿ760@ÿE1ÿ<1:ÿ:6;8ÿFÿ71585ÿ6:ÿ:?8ÿ5638ÿ:438@ÿ-<5:8679ÿ012
`
`A4BBÿ8D:8<7ÿ:?8ÿ<23>8=ÿ1.ÿ7605ÿ4<ÿ:?6:ÿ:=86:38<:ÿA88;@
`
`G12=ÿ?86B:?H6=8ÿC=1I478=ÿA4BBÿH1<:4<28ÿ:1ÿ31<4:1=ÿ012=ÿ?86B:?ÿ72=4<Jÿ:?8ÿFÿ086=B0ÿ:=86:38<:ÿH12=5859ÿ6<7ÿ.1=
`6:ÿB865:ÿ6<1:?8=ÿFÿ086=5ÿ72=4<JÿA?4H?ÿ012ÿ71ÿ<1:ÿ<887ÿ:1ÿ:6;8ÿKLMNOPQLE@ÿ-:ÿ45ÿ<1:ÿ;<1A<ÿ4.ÿKLMNOPQLE
`45ÿ56.8ÿ6<7ÿ8..8H:4I8ÿ4<ÿC81CB8ÿA?1ÿ=85:6=:ÿKLMNOPQLEÿ:=86:38<:ÿ31=8ÿ:?6<ÿFÿ086=5ÿ6.:8=ÿH13CB8:4<JÿF
`086=B0ÿ:=86:38<:ÿH12=585@
`
`RSTUVWXSYÿ[\]ÿ[\^_`ÿ_`abc^_ÿ_bd`ÿ`ee`[f_gÿheÿic^ÿj\k`ÿ\]iÿceÿfj`_`ÿ_ilmfcl_ÿnb_f`dÿo`ncpqÿ[\nnÿic^a
`j`\nfj[\a`ÿmackbd`aÿabrjfÿ\p\is
`
`ncpÿonccdÿ[`nnÿ[c^]f_ÿ?6I8ÿ?6CC8<87ÿ6<7ÿH6<ÿ4<H=8658ÿ012=ÿ=45;ÿ1.ÿ4<.8H:41<5ÿ72=4<Jÿ:=86:38<:ÿA4:?
`KLMNOPQLE@ÿtB117ÿ:85:5ÿ6=8ÿ<88787ÿ>8.1=8ÿ012ÿ5:6=:ÿ:=86:38<:ÿA4:?ÿKLMNOPQLE9ÿ72=4<Jÿ012=
`:=86:38<:ÿA4:?ÿKLMNOPQLE9ÿ6<7ÿ6.:8=A6=79ÿ65ÿ<88787@
`
`_`abc^_ÿb]e`[fbc]_ÿ_^[jÿ\_s
`uvqÿj`m\fbfb_ÿvÿcaÿWqÿ\]dÿ_jb]rn`_ÿwj`am`_ÿxc_f`aygÿz6:6BÿH6585ÿ1.ÿ{tÿ6<7ÿ?8C6:4:45ÿ?6I8ÿ?6CC8<87
`A4:?ÿHB67=4>4<8ÿ72=4<JÿHB4<4H6Bÿ5:27485@ÿ{8BBÿ012=ÿ?86B:?H6=8ÿC=1I478=ÿ=4J?:ÿ6A60ÿ4.ÿ012ÿJ8:ÿ6<0
`503C:135ÿ1.ÿ:?8ÿ.1BB1A4<Jÿ4<.8H:41<ÿ=8B6:87ÿC=1>B835ÿ1=ÿ4.ÿ6<0ÿ1.ÿ:?8ÿ503C:135ÿJ8:ÿA1=589ÿ4<HB274<J|
`.8I8=9ÿ6H?4<JÿC64<.2Bÿ325HB859ÿ?8676H?89ÿ.88B4<Jÿ1.ÿ>84<JÿJ8<8=6BB0ÿ2<A8BB9ÿB155ÿ1.ÿ6CC8:4:89ÿ>2=<4<J9
`:4<JB4<J9ÿ<23><855ÿ1=ÿ4:H?4<855ÿ1.ÿ:?8ÿ5;4<ÿ4<ÿ:?8ÿ6..8H:87ÿ6=869ÿ5;4<ÿ>B1:H?859ÿ>B45:8=87ÿ=65?9ÿ1=
`58I8=8ÿC64<@
`
`macra`__bk`ÿl^nfbec[\nÿn`^}c`][`mj\ncm\fjiÿw~RXygÿKQÿ45ÿ6ÿ=6=8ÿ>=64<ÿ4<.8H:41<ÿ:?6:ÿ2526BB0ÿB8675
`:1ÿ786:?ÿ1=ÿ58I8=8ÿ7456>4B4:0@ÿLB:?12J?ÿKQÿ?65ÿ<1:ÿ>88<ÿ588<ÿ4<ÿKÿC6:48<:5ÿ:6;4<JÿKLMNOPQLE9ÿ4:
`360ÿ?6CC8<ÿ4<ÿC81CB8ÿA4:?ÿA86;8<87ÿ4332<8ÿ505:835@ÿ{8BBÿ012=ÿ?86B:?H6=8ÿC=1I478=ÿ=4J?:ÿ6A60ÿ4.
`012ÿ?6I8ÿ6<0ÿ<8Aÿ1=ÿA1=58<4<Jÿ<82=1B1J4Hÿ54J<5ÿ1=ÿ503C:135@ÿ{?858ÿ360ÿ4<HB278|ÿA86;<855ÿ1<ÿ
`5478ÿ1.ÿ012=ÿ>1709ÿB155ÿ1.ÿH11=74<6:41<ÿ4<ÿ012=ÿ6=35ÿ6<7ÿB8J59ÿ78H=86587ÿ5:=8<J:?9ÿC=1>B835ÿA4:?
`>6B6<H89ÿH?6<J85ÿ4<ÿ012=ÿI4541<9ÿH?6<J85ÿ4<ÿ012=ÿ:?4<;4<Jÿ1=ÿ3831=09ÿH1<.2541<9ÿ1=ÿH?6<J85ÿ4<ÿ012=
`C8=51<6B4:0@
`
`nbk`aÿmacon`l_@ÿtB117ÿ:85:5ÿ5?12B7ÿ>8ÿC8=.1=387ÿ:1ÿH?8H;ÿ012=ÿB4I8=ÿ>8.1=8ÿ012ÿ5:6=:ÿ:6;4<J
`KLMNOPQLE@ÿ03C:135ÿ1.ÿB4I8=ÿC=1>B835ÿ360ÿ4<HB278|ÿ<625869ÿI134:4<J9ÿ5:136H?ÿC64<9ÿ:4=87<8559ÿB155
`1.ÿ6CC8:4:89ÿ76=;ÿ2=4<89ÿ1=ÿ012=ÿ5;4<ÿ1=ÿ:?8ÿA?4:85ÿ1.ÿ012=ÿ8085ÿ:2=<ÿ08BB1A@
`
`\nn`arb[ÿa`\[fbc]_ÿwjim`a_`]_bfbkbfb`_ygÿG12ÿ5?12B7ÿ5:1Cÿ:=86:38<:ÿ6<7ÿ588;ÿ4338746:8ÿ3874H6B
`6::8<:41<ÿ4.ÿ6<0ÿ54J<5ÿ1=ÿ503C:135ÿ1.ÿ6BB8=J4Hÿ=86H:41<5ÿ1HH2=@ÿ03C:135ÿ1.ÿ6<ÿ6BB8=J4Hÿ=86H:41<ÿ360
`4<HB278|ÿ5;4<ÿ=65?9ÿ5A8BB4<Jÿ1=ÿ4:H?4<Jÿ1.ÿ:?8ÿ.6H89ÿB4C59ÿ:1<J28ÿ1=ÿ:?=16:9ÿ1=ÿ:=12>B8ÿ>=86:?4<J@
`
`j`\afÿe\bn^a`gÿKLMNOPQLEÿ360ÿH6258ÿ?86=:ÿ.64B2=89ÿA?4H?ÿ386<5ÿ012=ÿ?86=:ÿ360ÿ<1:ÿC23Cÿ65ÿA8BBÿ65ÿ4:
`5?12B7@ÿP6BBÿ012=ÿ?86B:?H6=8ÿC=1I478=ÿ1=ÿJ1ÿ:1ÿ:?8ÿHB1585:ÿ838=J8<H0ÿ=113ÿ.1=ÿ3874H6Bÿ?8BCÿ=4J?:ÿ6A60
`4.ÿ012ÿ?6I8ÿ6<0ÿ54J<5ÿ1=ÿ503C:135ÿ52H?ÿ65ÿ5?1=:<855ÿ1.ÿ>=86:?9ÿ6ÿ.65:ÿ1=ÿ4==8J2B6=ÿ?86=:ÿ>86:9ÿ1=ÿ2<2526B
`5A8BB4<Jÿ4<ÿ012=ÿ>170@
`
`uj`ÿlc_fÿ[cllc]ÿ_bd`ÿ`ee`[f_ÿceÿRSTUVWXSYÿb][n^d`sÿ2CC8=ÿ=85C4=6:1=0ÿ4<.8H:41<9ÿ?8676H?89ÿ6<7ÿB1A
`A?4:8ÿ>B117ÿH8BBÿH12<:5@
`
`{?858ÿ6=8ÿ<1:ÿ6BBÿ:?8ÿC1554>B8ÿ5478ÿ8..8H:5ÿ1.ÿKLMNOPQLE@ÿP6BBÿ012=ÿ71H:1=ÿ.1=ÿ3874H6Bÿ67I4H8ÿ6>12:ÿ5478
`8..8H:5@ÿG12ÿ360ÿ=8C1=:ÿ5478ÿ8..8H:5ÿ:1ÿzELÿ6:ÿ YS g
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
` )
`
`
`
`12/19/23, 6:59 PM
`Side Effects & Safety Info | Mavenclad® (cladribine) Tablets
` ÿ ÿ
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`Please seefull Prescribing Information/Medication Guide,including serious side effects, for additional
`-./01/ÿ1//ÿ34..ÿ567896:;:<=ÿ?<@A6BCD:A<EF7G:9CD:A<ÿHI:G7JÿKLM.4NKLOÿ876:AI8ÿ8:G7ÿ7@@79D8Jÿ3PQÿ0NNKRKPL0.
`Important Safety Information.
`STUPQR0LRÿV03/RWÿSL3PQT0RKPLX
`
`ÿ ÿ
`
`&
`
`WHATIS MAVENCLAD?
`Z[\]ÿ?^ÿF\_`abc\de
`
`MAVENCLADis a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include
`fghijklgmÿK1ÿ0ÿUQ/1MQKURKPLÿT/NKMKL/ÿ41/NÿRPÿRQ/0RÿQ/.0U1KLOÿ3PQT1ÿP3ÿT4.RKU./ÿ1M./QP1K1ÿnfVoJÿRPÿKLM.4N/
`relapsing-remitting disease and active secondaryprogressive disease,in adults. Becauseofits safety
`Q/.0U1KLOpQ/TKRRKLOÿNK1/01/ÿ0LNÿ0MRKq/ÿ1/MPLN0QWÿUQPOQ/11Kq/ÿNK1/01/JÿKLÿ0N4.R1Xÿr/M041/ÿP3ÿKR1ÿ103/RW
`profile, MAVENCLADis generally used in people who havetried another MS medicine that they could not
`UQPs./JÿfghijklgmÿK1ÿO/L/Q0..Wÿ41/NÿKLÿU/PU./ÿtuPÿu0q/ÿRQK/Nÿ0LPRu/QÿfVÿT/NKMKL/ÿRu0RÿRu/WÿMP4.NÿLPR
`tolerate or that has not worked well enough.
`RP./Q0R/ÿPQÿRu0Rÿu01ÿLPRÿtPQv/Nÿt/..ÿ/LP4OuX
`
`MAVENCLADis not recommendedforuse in people withclinically isolated syndrome(CIS).
`fghijklgmÿK1ÿLPRÿQ/MPTT/LN/Nÿ3PQÿ41/ÿKLÿU/PU./ÿtKRuÿM.KLKM0..WÿK1P.0R/Nÿ1WLNQPT/ÿnkSVoX
`
`It is not known if MAVENCLADis safe and effective in children under 18 years of age, and is therefore not
`SRÿK1ÿLPRÿvLPtLÿK3ÿfghijklgmÿK1ÿ103/ÿ0LNÿ/33/MRKq/ÿKLÿMuK.NQ/Lÿ4LN/QÿwxÿW/0Q1ÿP3ÿ0O/Jÿ0LNÿK1ÿRu/Q/3PQ/ÿLPR
`recommended.
`Q/MPTT/LN/NX
`
`https://web.archive.orghweb/20231 004232146/https:/Avww.mavenclad.com/en/home/why-mavenclad/safety-and-side-effects.html
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`11/15
`
`
`
`Please seefull Prescribing Information/Medication Guide,including serious side effects, for additional
`-./01/ÿ1//ÿ34..ÿ567896:;:<=ÿ?<@A6BCD:A<EF7G:9CD:A<ÿHI:G7JÿKLM.4NKLOÿ876:AI8ÿ8:G7ÿ7@@79D8Jÿ3PQÿ0NNKRKPL0.
`Important Safety Information.
`STUPQR0LRÿV03/RWÿSL3PQT0RKPLX
`
`ÿ ÿ
`
`&
`
`WHATIS MAVENCLAD?
`Z[\]ÿ?^ÿF\_`abc\de
`
`MAVENCLADis a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include
`fghijklgmÿK1ÿ0ÿUQ/1MQKURKPLÿT/NKMKL/ÿ41/NÿRPÿRQ/0RÿQ/.0U1KLOÿ3PQT1ÿP3ÿT4.RKU./ÿ1M./QP1K1ÿnfVoJÿRPÿKLM.4N/
`relapsing-remitting disease and active secondaryprogressive disease,in adults. Becauseofits safety
`Q/.0U1KLOpQ/TKRRKLOÿNK1/01/ÿ0LNÿ0MRKq/ÿ1/MPLN0QWÿUQPOQ/11Kq/ÿNK1/01/JÿKLÿ0N4.R1Xÿr/M041/ÿP3ÿKR1ÿ103/RW
`profile, MAVENCLADis generally used in people who havetried another MS medicine that they could not
`UQPs./JÿfghijklgmÿK1ÿO/L/Q0..Wÿ41/NÿKLÿU/PU./ÿtuPÿu0q/ÿRQK/Nÿ0LPRu/QÿfVÿT/NKMKL/ÿRu0RÿRu/WÿMP4.NÿLPR
`tolerate or that has not worked well enough.
`RP./Q0R/ÿPQÿRu0Rÿu01ÿLPRÿtPQv/Nÿt/..ÿ/LP4OuX
`
`MAVENCLADis not recommendedforuse in people withclinically isolated syndrome(CIS).
`fghijklgmÿK1ÿLPRÿQ/MPTT/LN/Nÿ3PQÿ41/ÿKLÿU/PU./ÿtKRuÿM.KLKM0..WÿK1P.0R/Nÿ1WLNQPT/ÿnkSVoX
`
`It is not known if MAVENCLADis safe and effective in children under 18 years of age, and is therefore not
`SRÿK1ÿLPRÿvLPtLÿK3ÿfghijklgmÿK1ÿ103/ÿ0LNÿ/33/MRKq/ÿKLÿMuK.NQ/Lÿ4LN/QÿwxÿW/0Q1ÿP3ÿ0O/Jÿ0LNÿK1ÿRu/Q/3PQ/ÿLPR
`recommended.
`Q/MPTT/LN/NX
`
`https://web.archive.orghweb/20231 004232146/https:/Avww.mavenclad.com/en/home/why-mavenclad/safety-and-side-effects.html
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`11/15
`
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`-./012342ÿ637829ÿ-4701.32-04
`
`.3:84;<3=ÿ>?@ÿA?BCDÿCDEFGBCÿCFHDÿDIIDAJCKÿFLAMBHFLNO
`
`1FCPÿGIÿA?LADEÿQ>?MFNL?LAFDCRSÿUVWÿYZVW[\ÿ]V[[V^ÿZ_`[aZb`c_ÿdcVef\_cÿfgYacWbafVgYÿ`hVWaÿYbc__gfgiÿ]Vc
`b`gb_cj
`
`.3:84;<3=ÿ>?@ÿA?BCDÿkFEJlÿHDIDAJCÿFIÿBCDHÿHBEFLNÿmEDNL?LA@Sÿ7D>?MDCÿ>BCJÿLGJÿkDÿmEDNL?LJÿolDL
`JlD@ÿCJ?EJÿJED?J>DLJÿoFJlÿ.3:84;<3=ÿGEÿkDAG>DÿmEDNL?LJÿHBEFLNÿ.3:84;<3=ÿHGCFLNÿ?LHÿoFJlFLÿp
`>GLJlCÿ?IJDEÿJlDÿM?CJÿHGCDÿGIÿD?Alÿ@D?EM@ÿJED?J>DLJÿAGBECDSÿ9GBÿClGBMHÿCJGmÿJED?J>DLJÿoFJl
`.3:84;<3=ÿ?LHÿAGLJ?AJÿ@GBEÿlD?MJlA?EDÿmEGqFHDEÿEFNlJÿ?o?@ÿFIÿ@GBÿkDAG>DÿmEDNL?LJÿHBEFLN
`JED?J>DLJÿoFJlÿ.3:84;<3=S
`
`rVcÿ]_s`[_Yÿ^ZVÿ`c_ÿ`h[_ÿaVÿh_bVs_ÿdc_ig`gat
`
`UVWcÿZ_`[aZb`c_ÿdcVef\_cÿYZVW[\ÿVc\_cÿ`ÿdc_ig`gbuÿa_Yaÿh_]Vc_ÿuVWÿh_ifgÿuVWcÿvcYaÿ`g\ÿY_bVg\
`u_`c[uÿac_`as_gaÿbVWcY_ÿV]ÿwxyz{|}x~ÿaVÿs`_ÿYWc_ÿaZ`aÿuVWÿ`c_ÿgVaÿdc_ig`gaj
`
`Y_ÿ_]]_bafe_ÿhfcaZÿbVgacV[ÿbVgac`b_dafVgÿVgÿaZ_ÿ\`uYÿVgÿ^ZfbZÿuVWÿa`_ÿwxyz{|}x~ÿ`g\ÿ]Vcÿ`a
`[_`YaÿÿsVgaZYÿ`]a_cÿaZ_ÿ[`Yaÿ\VY_ÿV]ÿ_`bZÿu_`c[uÿac_`as_gaÿbVWcY_j
`
``[ÿaVÿuVWcÿZ_`[aZb`c_ÿdcVef\_cÿf]ÿuVWÿWY_ÿVc`[ÿbVgac`b_dafe_YÿaZ_ÿ df[[j
`
`UVWÿYZVW[\ÿWY_ÿ`ÿY_bVg\ÿs_aZV\ÿV]ÿhfcaZÿbVgacV[ÿVgÿaZ_ÿ\`uYÿVgÿ^ZfbZÿuVWÿa`_ÿwxyz{|}x~
``g\ÿ]Vcÿ`aÿ[_`Yaÿÿ^__Yÿ`]a_cÿuVWcÿ[`Yaÿ\VY_ÿV]ÿ_`bZÿu_`c[uÿac_`as_gaÿbVWcY_j
`
`rVcÿs`[_Yÿ^faZÿ]_s`[_ÿd`cag_cYÿ^ZVÿ`c_ÿ`h[_ÿaVÿh_bVs_ÿdc_ig`gat
`
`Y_ÿ_]]_bafe_ÿhfcaZÿbVgacV[ÿbVgac`b_dafVgÿ\WcfgiÿaZ_ÿ\`uYÿVgÿ^ZfbZÿuVWÿa`_ÿwxyz{|}x~ÿ`g\ÿ]Vc
``aÿ[_`YaÿÿsVgaZYÿ`]a_cÿaZ_ÿ[`Yaÿ\VY_ÿV]ÿ_`bZÿu_`c[uÿac_`as_gaÿbVWcY_j
`
`=GÿLGJÿa`_ÿwxyz{|}x~ÿf]ÿuVWt
`
`Z`e_ÿb`gb_cÿs`[fig`gbuj
`
``c_ÿdc_ig`gaÿd[`gÿaVÿh_bVs_ÿdc_ig`gaÿVcÿ`c_ÿ`ÿ^Vs`gÿV]ÿbZf[\h_`cfgiÿ`i_ÿVcÿ`ÿs`gÿ`h[_ÿaVÿ]`aZ_cÿ`
`bZf[\ÿ`g\ÿuVWÿ`c_ÿgVaÿWYfgiÿhfcaZÿbVgacV[j
`
``c_ÿhc_`Ya]__\fgij
`
``c_ÿZWs`gÿfssWgV\_vbf_gbuÿefcWYÿyÿdVYfafe_j
`
`Z`e_ÿ`bafe_ÿfg]_bafVgYÿfgb[W\fgiÿaWh_cbW[VYfYÿÿZ_d`afafYÿÿVcÿ|j
`
``c_ÿ`[[_cifbÿaVÿb[`\cfhfg_j
`
`DIGEDÿ@GBÿJ?PDÿ.3:84;<3=KÿJDMMÿ@GBEÿlD?MJlA?EDÿmEGqFHDEÿ?kGBJÿ?MMÿGIÿ@GBEÿ>DHFA?MÿAGLHFJFGLCKÿFLAMBHFLN
`FIÿ@GBt
`
`aZfgÿuVWÿZ`e_ÿ`gÿfg]_bafVgj
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
`-./012342ÿ637829ÿ-4701.32-04
`
`.3:84;<3=ÿ>?@ÿA?BCDÿCDEFGBCÿCFHDÿDIIDAJCKÿFLAMBHFLNO
`
`1FCPÿGIÿA?LADEÿQ>?MFNL?LAFDCRSÿUVWÿYZVW[\ÿ]V[[V^ÿZ_`[aZb`c_ÿdcVef\_cÿfgYacWbafVgYÿ`hVWaÿYbc__gfgiÿ]Vc
`b`gb_cj
`
`.3:84;<3=ÿ>?@ÿA?BCDÿkFEJlÿHDIDAJCÿFIÿBCDHÿHBEFLNÿmEDNL?LA@Sÿ7D>?MDCÿ>BCJÿLGJÿkDÿmEDNL?LJÿolDL
`JlD@ÿCJ?EJÿJED?J>DLJÿoFJlÿ.3:84;<3=ÿGEÿkDAG>DÿmEDNL?LJÿHBEFLNÿ.3:84;<3=ÿHGCFLNÿ?LHÿoFJlFLÿp
`>GLJlCÿ?IJDEÿJlDÿM?CJÿHGCDÿGIÿD?Alÿ@D?EM@ÿJED?J>DLJÿAGBECDSÿ9GBÿClGBMHÿCJGmÿJED?J>DLJÿoFJl
`.3:84;<3=ÿ?LHÿAGLJ?AJÿ@GBEÿlD?MJlA?EDÿmEGqFHDEÿEFNlJÿ?o?@ÿFIÿ@GBÿkDAG>DÿmEDNL?LJÿHBEFLN
`JED?J>DLJÿoFJlÿ.3:84;<3=S
`
`rVcÿ]_s`[_Yÿ^ZVÿ`c_ÿ`h[_ÿaVÿh_bVs_ÿdc_ig`gat
`
`UVWcÿZ_`[aZb`c_ÿdcVef\_cÿYZVW[\ÿVc\_cÿ`ÿdc_ig`gbuÿa_Yaÿh_]Vc_ÿuVWÿh_ifgÿuVWcÿvcYaÿ`g\ÿY_bVg\
`u_`c[uÿac_`as_gaÿbVWcY_ÿV]ÿwxyz{|}x~ÿaVÿs`_ÿYWc_ÿaZ`aÿuVWÿ`c_ÿgVaÿdc_ig`gaj
`
`Y_ÿ_]]_bafe_ÿhfcaZÿbVgacV[ÿbVgac`b_dafVgÿVgÿaZ_ÿ\`uYÿVgÿ^ZfbZÿuVWÿa`_ÿwxyz{|}x~ÿ`g\ÿ]Vcÿ`a
`[_`YaÿÿsVgaZYÿ`]a_cÿaZ_ÿ[`Yaÿ\VY_ÿV]ÿ_`bZÿu_`c[uÿac_`as_gaÿbVWcY_j
`
``[ÿaVÿuVWcÿZ_`[aZb`c_ÿdcVef\_cÿf]ÿuVWÿWY_ÿVc`[ÿbVgac`b_dafe_YÿaZ_ÿ df[[j
`
`UVWÿYZVW[\ÿWY_ÿ`ÿY_bVg\ÿs_aZV\ÿV]ÿhfcaZÿbVgacV[ÿVgÿaZ_ÿ\`uYÿVgÿ^ZfbZÿuVWÿa`_ÿwxyz{|}x~
``g\ÿ]Vcÿ`aÿ[_`Yaÿÿ^__Yÿ`]a_cÿuVWcÿ[`Yaÿ\VY_ÿV]ÿ_`bZÿu_`c[uÿac_`as_gaÿbVWcY_j
`
`rVcÿs`[_Yÿ^faZÿ]_s`[_ÿd`cag_cYÿ^ZVÿ`c_ÿ`h[_ÿaVÿh_bVs_ÿdc_ig`gat
`
`Y_ÿ_]]_bafe_ÿhfcaZÿbVgacV[ÿbVgac`b_dafVgÿ\WcfgiÿaZ_ÿ\`uYÿVgÿ^ZfbZÿuVWÿa`_ÿwxyz{|}x~ÿ`g\ÿ]Vc
``aÿ[_`YaÿÿsVgaZYÿ`]a_cÿaZ_ÿ[`Yaÿ\VY_ÿV]ÿ_`bZÿu_`c[uÿac_`as_gaÿbVWcY_j
`
`=GÿLGJÿa`_ÿwxyz{|}x~ÿf]ÿuVWt
`
`Z`e_ÿb`gb_cÿs`[fig`gbuj
`
``c_ÿdc_ig`gaÿd[`gÿaVÿh_bVs_ÿdc_ig`gaÿVcÿ`c_ÿ`ÿ^Vs`gÿV]ÿbZf[\h_`cfgiÿ`i_ÿVcÿ`ÿs`gÿ`h[_ÿaVÿ]`aZ_cÿ`
`bZf[\ÿ`g\ÿuVWÿ`c_ÿgVaÿWYfgiÿhfcaZÿbVgacV[j
`
``c_ÿhc_`Ya]__\fgij
`
``c_ÿZWs`gÿfssWgV\_vbf_gbuÿefcWYÿyÿdVYfafe_j
`
`Z`e_ÿ`bafe_ÿfg]_bafVgYÿfgb[W\fgiÿaWh_cbW[VYfYÿÿZ_d`afafYÿÿVcÿ|j
`
``c_ÿ`[[_cifbÿaVÿb[`\cfhfg_j
`
`DIGEDÿ@GBÿJ?PDÿ.3:84;<3=KÿJDMMÿ@GBEÿlD?MJlA?EDÿmEGqFHDEÿ?kGBJÿ?MMÿGIÿ@GBEÿ>DHFA?MÿAGLHFJFGLCKÿFLAMBHFLN
`FIÿ@GBt
`
`aZfgÿuVWÿZ`e_ÿ`gÿfg]_bafVgj
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`-./0ÿ2.3045ÿ2.305ÿ67ÿ89.4ÿ26ÿ2.30ÿ:0;<=<40>ÿ2-.2ÿ.??0=2ÿ@6A7ÿ<::A40ÿ>@>20:ÿ67ÿB966;ÿ=099>5ÿ67ÿ62-07
`270.2:042>ÿ?67ÿCDEÿF072.<4ÿ:0;<=<40>ÿ=.4ÿ<4=70.>0ÿ@6A7ÿ7<>3ÿ6?ÿG022<4Gÿ.4ÿ<4?0=2<64E
`
`-./0ÿ-.;ÿ.ÿ70=042ÿ/.==<4.2<64ÿ67ÿ.70ÿ>=-0;A90;ÿ26ÿ70=0</0ÿ.4@ÿ/.==<4.2<64>EÿH6Aÿ>-6A9;ÿ462ÿ70=0</0ÿ9</0
`67ÿ9</0I.2204A.20;ÿ/.==<40>ÿJ<2-<4ÿ2-0ÿKÿ26ÿLÿJ003>ÿ870=0;<4Gÿ270.2:042ÿJ<2-ÿCMNOPFQMRÿ67ÿ70=0</0
`2-0>0ÿ2@80>ÿ6?ÿ/.==<40>ÿ;A7<4Gÿ@6A7ÿ270.2:042ÿJ<2-ÿCMNOPFQMRÿ.4;ÿA490>>ÿ;<70=20;ÿB@ÿ@6A7ÿ-0.92-=.70
`876/<;07E
`
`-./0ÿ-0.72ÿ?.<9A70E
`
`-./0ÿ67ÿ-./0ÿ-.;ÿ=.4=07E
`
`-./0ÿ9</07ÿ67ÿ3<;40@ÿ876B90:>E
`
`.70ÿB70.>2?00;<4Gÿ67ÿ89.4ÿ26ÿB70.>2?00;EÿS2ÿ<>ÿ462ÿ346J4ÿ<?ÿCMNOPFQMRÿ8.>>0>ÿ<426ÿ@6A7ÿB70.>2ÿ:<93EÿR6
`462ÿB70.>2?00;ÿ64ÿ2-0ÿ;.@>ÿ64ÿJ-<=-ÿ@6Aÿ2.30ÿCMNOPFQMR5ÿ.4;ÿ?67ÿTUÿ;.@>ÿ.?207ÿ2-0ÿ9.>2ÿ;6>0E
`
`VWXÿZ[W\]^ÿ_ÿ`abcÿdefghijekl
`
`CMNOPFQMRÿ<>ÿG</04ÿ.>ÿ2J6ÿ@0.79@ÿ270.2:042ÿ=6A7>0>E
`
`O.=-ÿ@0.79@ÿ270.2:042ÿ=6A7>0ÿ=64><>2>ÿ6?ÿmÿ270.2:042ÿJ003>ÿn.9>6ÿ=.990;ÿ=@=90>oÿ2-.2ÿJ<99ÿB0ÿ.B6A2ÿ.
`:642-ÿ.8.72E
`
`p.30ÿCMNOPFQMRÿJ<2-ÿJ.207ÿ.4;ÿ>J.996JÿJ-690ÿJ<2-6A2ÿ=-0J<4GEÿCMNOPFQMRÿ=.4ÿB0ÿ2.304ÿJ<2-ÿ67
`J<2-6A2ÿ?66;E
`
`DJ.996JÿCMNOPFQMRÿ7<G-2ÿ.J.@ÿ.?207ÿ6804<4Gÿ2-0ÿB9<>207ÿ8.=3E
`
`H6A7ÿ-.4;>ÿ:A>2ÿB0ÿ;7@ÿJ-04ÿ-.4;9<4GÿCMNOPFQMRÿ.4;ÿJ.>-0;ÿJ099ÿJ<2-ÿJ.207ÿ.?207J.7;>E
`
`Q<:<2ÿ=642.=2ÿJ<2-ÿ@6A7ÿ>3<4EÿM/6<;ÿ26A=-<4Gÿ@6A7ÿ46>05ÿ0@0>ÿ.4;ÿ62-07ÿ8.72>ÿ6?ÿ2-0ÿB6;@EÿS?ÿ@6AÿG02
`CMNOPFQMRÿ64ÿ@6A7ÿ>3<4ÿ67ÿ64ÿ.4@ÿ>A7?.=05ÿJ.>-ÿ<2ÿ7<G-2ÿ.J.@ÿJ<2-ÿJ.207E
`
`p.30ÿCMNOPFQMRÿ.2ÿ90.>2ÿqÿ-6A7>ÿ.8.72ÿ?76:ÿ62-07ÿ:0;<=<40>ÿ2.304ÿB@ÿ:6A2-ÿ;A7<4Gÿ2-0ÿKIÿ26ÿrI;.@
`CMNOPFQMRÿ270.2:042ÿJ003E
`
`S?ÿ@6Aÿ:<>>ÿ.ÿ;6>05ÿ2.30ÿ<2ÿ.>ÿ>664ÿ.>ÿ@6Aÿ70:0:B07ÿ64ÿ2-0ÿ>.:0ÿ;.@EÿS?ÿ2-0ÿJ-690ÿ;.@ÿ8.>>0>ÿB0?670
`@6Aÿ70:0:B075ÿ2.30ÿ@6A7ÿ:<>>0;ÿ;6>0ÿ2-0ÿ40s2ÿ;.@EÿR6ÿ462ÿ2.30ÿmÿ;6>0>ÿ.2ÿ2-0ÿ>.:0ÿ2<:0EÿS4>20.;5ÿ@6A
`J<99ÿ0s204;ÿ2-0ÿ4A:B07ÿ6?ÿ;.@>ÿ<4ÿ2-.2ÿ270.2:042ÿJ003E
`
`H6A7ÿ-0.92-=.70ÿ876/<;07ÿJ<99ÿ=642<4A0ÿ26ÿ:64<267ÿ@6A7ÿ-0.92-ÿ;A7<4Gÿ2-0ÿmÿ@0.79@ÿ270.2:042ÿ=6A7>0>5ÿ.4;ÿ?67
`.2ÿ90.>2ÿ.462-07ÿmÿ@0.7>ÿ;A7<4GÿJ-<=-ÿ@6Aÿ;6ÿ462ÿ400;ÿ26ÿ2.30ÿCMNOPFQMREÿS2ÿ<>ÿ462ÿ346J4ÿ<?ÿCMNOPFQMR
`<>ÿ>.?0ÿ.4;ÿ0??0=2</0ÿ<4ÿ806890ÿJ-6ÿ70>2.72ÿCMNOPFQMRÿ270.2:042ÿ:670ÿ2-.4ÿmÿ@0.7>ÿ.?207ÿ=6:8902<4Gÿm
`@0.79@ÿ270.2:042ÿ=6A7>0>E
`
`defghijekÿtauÿta\ZcÿZcvwW\ZÿZw^cÿcxxct`Zyÿ_xÿzW\ÿ[a{cÿauzÿWxÿ`[cZcÿZz|}`W|Zÿ]wZ`c^ÿ~c]WXÿta]]ÿzW\v
`[ca]`[tavcÿ}vW{w^cvÿvw[`ÿaXaz
`
`]WXÿ~]WW^ÿtc]]ÿtW\u`Zÿ-./0ÿ-.88040;ÿ.4;ÿ=.4ÿ<4=70.>0ÿ@6A7ÿ7<>3ÿ6?ÿ<4?0=2<64>ÿ;A7<4Gÿ270.2:042ÿJ<2-
`CMNOPFQMREÿ966;ÿ20>2>ÿ.70ÿ400;0;ÿB0?670ÿ@6Aÿ>2.72ÿ270.2:042ÿJ<2-ÿCMNOPFQMR5ÿ;A7<4Gÿ@6A7
`270.2:042ÿJ<2-ÿCMNOPFQMR5ÿ.4;ÿ.?207J.7;5ÿ.>ÿ400;0;E
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
`-./0ÿ2.3045ÿ2.305ÿ67ÿ89.4ÿ26ÿ2.30ÿ:0;<=<40>ÿ2-.2ÿ.??0=2ÿ@6A7ÿ<::A40ÿ>@>20:ÿ67ÿB966;ÿ=099>5ÿ67ÿ62-07
`270.2:042>ÿ?67ÿCDEÿF072.<4ÿ:0;<=<40>ÿ=.4ÿ<4=70.>0ÿ@6A7ÿ7<>3ÿ6?ÿG022<4Gÿ.4ÿ<4?0=2<64E
`
`-./0ÿ-.;ÿ.ÿ70=042ÿ/.==<4.2<64ÿ67ÿ.70ÿ>=-0;A90;ÿ26ÿ70=0</0ÿ.4@ÿ/.==<4.2<64>EÿH6Aÿ>-6A9;ÿ462ÿ70=0</0ÿ9</0
`67ÿ9</0I.2204A.20;ÿ/.==<40>ÿJ<2-<4ÿ2-0ÿKÿ26ÿLÿJ003>ÿ870=0;<4Gÿ270.2:042ÿJ<2-ÿCMNOPFQMRÿ67ÿ70=0</0
`2-0>0ÿ2@80>ÿ6?ÿ/.==<40>ÿ;A7<4Gÿ@6A7ÿ270.2:042ÿJ<2-ÿCMNOPFQMRÿ.4;ÿA490>>ÿ;<70=20;ÿB@ÿ@6A7ÿ-0.92-=.70
`876/<;07E
`
`-./0ÿ-0.72ÿ?.<9A70E
`
`-./0ÿ67ÿ-./0ÿ-.;ÿ=.4=07E
`
`-./0ÿ9</07ÿ67ÿ3<;40@ÿ876B90:>E
`
`.70ÿB70.>2?00;<4Gÿ67ÿ89.4ÿ26ÿB70.>2?00;EÿS2ÿ<>ÿ462ÿ346J4ÿ<?ÿCMNOPFQMRÿ8.>>0>ÿ<426ÿ@6A7ÿB70.>2ÿ:<93EÿR6
`462ÿB70.>2?00;ÿ64ÿ2-0ÿ;.@>ÿ64ÿJ-<=-ÿ@6Aÿ2.30ÿCMNOPFQMR5ÿ.4;ÿ?67ÿTUÿ;.@>ÿ.?207ÿ2-0ÿ9.>2ÿ;6>0E
`
`VWXÿZ[W\]^ÿ_ÿ`abcÿdefghijekl
`
`CMNOPFQMRÿ<>ÿG</04ÿ.>ÿ2J6ÿ@0.79@ÿ270.2:042ÿ=6A7>0>E
`
`O.=-ÿ@0.79@ÿ270.2:042ÿ=6A7>0ÿ=64><>2>ÿ6?ÿmÿ270.2:042ÿJ003>ÿn.9>6ÿ=.990;ÿ=@=90>oÿ2-.2ÿJ<99ÿB0ÿ.B6A2ÿ.
`:642-ÿ.8.72E
`
`p.30ÿCMNOPFQMRÿJ<2-ÿJ.207ÿ.4;ÿ>J.996JÿJ-690ÿJ<2-6A2ÿ=-0J<4GEÿCMNOPFQMRÿ=.4ÿB0ÿ2.304ÿJ<2-ÿ67
`J<2-6A2ÿ?66;E
`
`DJ.996JÿCMNOPFQMRÿ7<G-2ÿ.J.@ÿ.?207ÿ6804<4Gÿ2-0ÿB9<>207ÿ8.=3E
`
`H6A7ÿ-.4;>ÿ:A>2ÿB0ÿ;7@ÿJ-04ÿ-.4;9<4GÿCMNOPFQMRÿ.4;ÿJ.>-0;ÿJ099ÿJ<2-ÿJ.207ÿ.?207J.7;>E
`
`Q<:<2ÿ=642.=2ÿJ<2-ÿ@6A7ÿ>3<4EÿM/6<;ÿ26A=-<4Gÿ@6A7ÿ46>05ÿ0@0>ÿ.4;ÿ62-07ÿ8.72>ÿ6?ÿ2-0ÿB6;@EÿS?ÿ@6AÿG02
`CMNOPFQMRÿ64ÿ@6A7ÿ>3<4ÿ67ÿ64ÿ.4@ÿ>A7?.=05ÿJ.>-ÿ<2ÿ7<G-2ÿ.J.@ÿJ<2-ÿJ.207E
`
`p.30ÿCMNOPFQMRÿ.2ÿ90.>2ÿqÿ-6A7>ÿ.8.72ÿ?76:ÿ62-07ÿ:0;<=<40>ÿ2.304ÿB@ÿ:6A2-ÿ;A7<4Gÿ2-0ÿKIÿ26ÿrI;.@
`CMNOPFQMRÿ270.2:042ÿJ003E
`
`S?ÿ@6Aÿ:<>>ÿ.ÿ;6>05ÿ2.30ÿ<2ÿ.>ÿ>664ÿ.>ÿ@6Aÿ70:0:B07ÿ64ÿ2-0ÿ>.:0ÿ;.@EÿS?ÿ2-0ÿJ-690ÿ;.@ÿ8.>>0>ÿB0?670
`@6Aÿ70:0:B075ÿ2.30ÿ@6A7ÿ:<>>0;ÿ;6>0ÿ2-0ÿ40s2ÿ;.@EÿR6ÿ462ÿ2.30ÿmÿ;6>0>ÿ.2ÿ2-0ÿ>.:0ÿ2<:0EÿS4>20.;5ÿ@6A
`J<99ÿ0s204;ÿ2-0ÿ4A:B07ÿ6?ÿ;.@>ÿ<4ÿ2-.2ÿ270.2:042ÿJ003E
`
`H6A7ÿ-0.92-=.70ÿ876/<;07ÿJ<99ÿ=642<4A0ÿ26ÿ:64<267ÿ@6A7ÿ-0.92-ÿ;A7<4Gÿ2-0ÿmÿ@0.79@ÿ270.2:042ÿ=6A7>0>5ÿ.4;ÿ?67
`.2ÿ90.>2ÿ.462-07ÿmÿ@0.7>ÿ;A7<4GÿJ-<=-ÿ@6Aÿ;6ÿ462ÿ400;ÿ26ÿ2.30ÿCMNOPFQMREÿS2ÿ<>ÿ462ÿ346J4ÿ<?ÿCMNOPFQMR
`<>ÿ>.?0ÿ.4;ÿ0??0=2</0ÿ<4ÿ806890ÿJ-6ÿ70>2.72ÿCMNOPFQMRÿ270.2:042ÿ:670ÿ2-.4ÿmÿ@0.7>ÿ.?207ÿ=6:8902<4Gÿm
`@0.79@ÿ270.2:042ÿ=6A7>0>E
`
`defghijekÿtauÿta\ZcÿZcvwW\ZÿZw^cÿcxxct`Zyÿ_xÿzW\ÿ[a{cÿauzÿWxÿ`[cZcÿZz|}`W|Zÿ]wZ`c^ÿ~c]WXÿta]]ÿzW\v
`[ca]`[tavcÿ}vW{w^cvÿvw[`ÿaXaz
`
`]WXÿ~]WW^ÿtc]]ÿtW\u`Zÿ-./0ÿ-.88040;ÿ.4;ÿ=.4ÿ<4=70.>0ÿ@6A7ÿ7<>3ÿ6?ÿ<4?0=2<64>ÿ;A7<4Gÿ270.2:042ÿJ<2-
`CMNOPFQMREÿ966;ÿ20>2>ÿ.70ÿ400;0;ÿB0?670ÿ@6Aÿ>2.72ÿ270.2:042ÿJ<2-ÿCMNOPFQMR5ÿ;A7<4Gÿ@6A7
`270.2:042ÿJ<2-ÿCMNOPFQMR5ÿ.4;ÿ.?207J.7;5ÿ.>ÿ400;0;E
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`-./012-ÿ045.67014-ÿ-268ÿ9-:
`
`;<=ÿ8.>97070-ÿ<ÿ1/ÿ?=ÿ94@ÿ-804AB.-ÿC8./>.-ÿD1-7./EFÿHIJIKÿLIMNMÿOPÿQRÿISTÿUNVIJWJWMÿUIXNÿUIVVNSNT
`YWJUÿLKITZW[WSNÿT\ZWS]ÿLKWSWLIKÿMJ\TWNM^ÿQNKKÿ_O\ZÿUNIKJULIZNÿVZOXWTNZÿZW]UJÿIYI_ÿWPÿ_O\ÿ]NJÿIS_
`M_`VJO`MÿOPÿJUNÿPOKKOYWS]ÿWSPNLJWOSÿZNKIJNTÿVZO[KN`MÿOZÿWPÿIS_ÿOPÿJUNÿM_`VJO`Mÿ]NJÿYOZMNaÿWSLK\TWS]b
`PNXNZaÿILUWS]ÿVIWSP\Kÿ`\MLKNMaÿUNITILUNaÿPNNKWS]ÿOPÿ[NWS]ÿ]NSNZIKK_ÿ\SYNKKaÿKOMMÿOPÿIVVNJWJNaÿ[\ZSWS]a
`JWS]KWS]aÿS\`[SNMMÿOZÿWJLUWSNMMÿOPÿJUNÿMcWSÿWSÿJUNÿIPPNLJNTÿIZNIaÿMcWSÿ[KOJLUNMaÿ[KWMJNZNTÿZIMUaÿOZÿMNXNZN
`VIWS^
`
`>/1A/.--0d.ÿe2B705169BÿB.2f1.46.>89B1>978gÿChijEFÿklmÿWMÿIÿZIZNÿ[ZIWSÿWSPNLJWOSÿJUIJÿ\M\IKK_ÿKNITMÿJO
`TNIJUÿOZÿMNXNZNÿTWMI[WKWJ_^ÿnKJUO\]UÿklmÿUIMÿSOJÿ[NNSÿMNNSÿWSÿloÿVIJWNSJMÿJIcWS]ÿlnpqrsmntaÿWJ
``I_ÿUIVVNSÿWSÿVNOVKNÿYWJUÿYNIcNSNTÿW``\SNÿM_MJN`M^ÿQNKKÿ_O\ZÿUNIKJULIZNÿVZOXWTNZÿZW]UJÿIYI_ÿWP
`_O\ÿUIXNÿIS_ÿSNYÿOZÿYOZMNSWS]ÿSN\ZOKO]WLÿMW]SMÿOZÿM_`VJO`M^ÿQUNMNÿ`I_ÿWSLK\TNbÿYNIcSNMMÿOSÿu
`MWTNÿOPÿ_O\Zÿ[OT_aÿKOMMÿOPÿLOOZTWSIJWOSÿWSÿ_O\ZÿIZ`MÿISTÿKN]MaÿTNLZNIMNTÿMJZNS]JUaÿVZO[KN`MÿYWJU
`[IKISLNaÿLUIS]NMÿWSÿ_O\ZÿXWMWOSaÿLUIS]NMÿWSÿ_O\ZÿJUWScWS]ÿOZÿ`N`OZ_aÿLOSP\MWOSaÿOZÿLUIS]NMÿWSÿ_O\Z
`VNZMOSIKWJ_^
`
`B0d./ÿ>/1vB.e-^ÿRKOOTÿJNMJMÿMUO\KTÿ[NÿVNZPOZ`NTÿJOÿLUNLcÿ_O\ZÿKWXNZÿ[NPOZNÿ_O\ÿMJIZJÿJIcWS]ÿlnpqrsmnt^
`o_`VJO`MÿOPÿKWXNZÿVZO[KN`Mÿ`I_ÿWSLK\TNbÿSI\MNIaÿXO`WJWS]aÿMJO`ILUÿVIWSaÿJWZNTSNMMaÿKOMMÿOPÿIVVNJWJNa
`TIZcÿ\ZWSNaÿOZÿ_O\ZÿMcWSÿOZÿJUNÿYUWJNMÿOPÿ_O\ZÿN_NMÿJ\ZSÿ_NKKOY^
`
`9BB./A06ÿ/.967014-ÿC8g>./-.4-070d070.-EFÿwO\ÿMUO\KTÿMJOVÿJZNIJ`NSJÿISTÿMNNcÿW``NTWIJNÿ`NTWLIK
`IJJNSJWOSÿWPÿIS_ÿMW]SMÿOZÿM_`VJO`MÿOPÿIKKNZ]WLÿZNILJWOSMÿOLL\Z^ÿo_`VJO`MÿOPÿISÿIKKNZ]WLÿZNILJWOSÿ`I_
`WSLK\TNbÿMcWSÿZIMUaÿMYNKKWS]ÿOZÿWJLUWS]ÿOPÿJUNÿPILNaÿKWVMaÿJOS]\NÿOZÿJUZOIJaÿOZÿJZO\[KNÿ[ZNIJUWS]^
`
`8.9/7ÿ590B2/.Fÿlnpqrsmntÿ`I_ÿLI\MNÿUNIZJÿPIWK\ZNaÿYUWLUÿ`NISMÿ_O\ZÿUNIZJÿ`I_ÿSOJÿV\`VÿIMÿYNKKÿIMÿWJ
`MUO\KT^ÿsIKKÿ_O\ZÿUNIKJULIZNÿVZOXWTNZÿOZÿ]OÿJOÿJUNÿLKOMNMJÿN`NZ]NSL_ÿZOO`ÿPOZÿ`NTWLIKÿUNKVÿZW]UJÿIYI_
`WPÿ_O\ÿUIXNÿIS_ÿMW]SMÿOZÿM_`VJO`MÿM\LUÿIMÿMUOZJSNMMÿOPÿ[ZNIJUaÿIÿPIMJÿOZÿWZZN]\KIZÿUNIZJÿ[NIJaÿOZÿ\S\M\IK
`MYNKKWS]ÿWSÿ_O\Zÿ[OT_^
`
`;8.ÿe1-7ÿ61ee14ÿ-0@.ÿ.55.67-ÿ15ÿixyz{?jx|ÿ046B2@.:ÿ\VVNZÿZNMVWZIJOZ_ÿWSPNLJWOSaÿUNITILUNaÿISTÿKOY
`YUWJNÿ[KOOTÿLNKKÿLO\SJM^
`
`QUNMNÿIZNÿSOJÿIKKÿJUNÿVOMMW[KNÿMWTNÿNPPNLJMÿOPÿlnpqrsmnt^ÿsIKKÿ_O\ZÿTOLJOZÿPOZÿ`NTWLIKÿITXWLNÿI[O\JÿMWTN
`NPPNLJM^ÿwO\ÿ`I_ÿZNVOZJÿMWTNÿNPPNLJMÿJOÿHtnÿIJÿ}~~|x~}F
`
`kKNIMNÿMNNÿP\KKÿh/.-6/0v04Aÿ451/e97014i.@0697014ÿ20@.aÿWSLK\TWS]ÿ-./012-ÿ-0@.ÿ.55.67-aÿPOZÿITTWJWOSIK
` `VOZJISJÿoIPNJ_ÿ SPOZ`IJWOS^
`
`ÿ ÿ
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
` *
`
`
`
`-./012-ÿ045.67014-ÿ-268ÿ9-:
`
`;<=ÿ8.>97070-ÿ<ÿ1/ÿ?=ÿ94@ÿ-804AB.-ÿC8./>.-ÿD1-7./EFÿHIJIKÿLIMNMÿOPÿQRÿISTÿUNVIJWJWMÿUIXNÿUIVVNSNT
`YWJUÿLKITZW[WSNÿT\ZWS]ÿLKWSWLIKÿMJ\TWNM^ÿQNKKÿ_O\ZÿUNIKJULIZNÿVZOXWTNZÿZW]UJÿIYI_ÿWPÿ_O\ÿ]NJÿIS_
`M_`VJO`MÿOPÿJUNÿPOKKOYWS]ÿWSPNLJWOSÿZNKIJNTÿVZO[KN`MÿOZÿWPÿIS_ÿOPÿJUNÿM_`VJO`Mÿ]NJÿYOZMNaÿWSLK\TWS]b
`PNXNZaÿILUWS]ÿVIWSP\Kÿ`\MLKNMaÿUNITILUNaÿPNNKWS]ÿOPÿ[NWS]ÿ]NSNZIKK_ÿ\SYNKKaÿKOMMÿOPÿIVVNJWJNaÿ[\ZSWS]a
`JWS]KWS]aÿS\`[SNMMÿOZÿWJLUWSNMMÿOPÿJUNÿMcWSÿWSÿJUNÿIPPNLJNTÿIZNIaÿMcWSÿ[KOJLUNMaÿ[KWMJNZNTÿZIMUaÿOZÿMNXNZN
`VIWS^
`
`>/1A/.--0d.ÿe2B705169BÿB.2f1.46.>89B1>978gÿChijEFÿklmÿWMÿIÿZIZNÿ[ZIWSÿWSPNLJWOSÿJUIJÿ\M\IKK_ÿKNITMÿJO
`TNIJUÿOZÿMNXNZNÿTWMI[WKWJ_^ÿnKJUO\]UÿklmÿUIMÿSOJÿ[NNSÿMNNSÿWSÿloÿVIJWNSJMÿJIcWS]ÿlnpqrsmntaÿWJ
``I_ÿUIVVNSÿWSÿVNOVKNÿYWJUÿYNIcNSNTÿW``\SNÿM_MJN`M^ÿQNKKÿ_O\ZÿUNIKJULIZNÿVZOXWTNZÿZW]UJÿIYI_ÿWP
`_O\ÿUIXNÿIS_ÿSNYÿOZÿYOZMNSWS]ÿSN\ZOKO]WLÿMW]SMÿOZÿM_`VJO`M^ÿQUNMNÿ`I_ÿWSLK\TNbÿYNIcSNMMÿOSÿu
`MWTNÿOPÿ_O\Zÿ[OT_aÿKOMMÿOPÿLOOZTWSIJWOSÿWSÿ_O\ZÿIZ`MÿISTÿKN]MaÿTNLZNIMNTÿMJZNS]JUaÿVZO[KN`MÿYWJU
`[IKISLNaÿLUIS]NMÿWSÿ_O\ZÿXWMWOSaÿLUIS]NMÿWSÿ_O\ZÿJUWScWS]ÿOZÿ`N`OZ_aÿLOSP\MWOSaÿOZÿLUIS]NMÿWSÿ_O\Z
`VNZMOSIKWJ_^
`
`B0d./ÿ>/1vB.e-^ÿRKOOTÿJNMJMÿMUO\KTÿ[NÿVNZPOZ`NTÿJOÿLUNLcÿ_O\ZÿKWXNZÿ[NPOZNÿ_O\ÿMJIZJÿJIcWS]ÿlnpqrsmnt^
`o_`VJO`MÿOPÿKWXNZÿVZO[KN`Mÿ`I_ÿWSLK\TNbÿSI\MNIaÿXO`WJWS]aÿMJO`ILUÿVIWSaÿJWZNTSNMMaÿKOMMÿOPÿIVVNJWJNa
`TIZcÿ\ZWSNaÿOZÿ_O\ZÿMcWSÿOZÿJUNÿYUWJNMÿOPÿ_O\ZÿN_NMÿJ\ZSÿ_NKKOY^
`
`9BB./A06ÿ/.967014-ÿC8g>./-.4-070d070.-EFÿwO\ÿMUO\KTÿMJOVÿJZNIJ`NSJÿISTÿMNNcÿW``NTWIJNÿ`NTWLIK
`IJJNSJWOSÿWPÿIS_ÿMW]SMÿOZÿM_`VJO`MÿOPÿIKKNZ]WLÿZNILJWOSMÿOLL\Z^ÿo_`VJO`MÿOPÿISÿIKKNZ]WLÿZNILJWOSÿ`I_
`WSLK\TNbÿMcWSÿZIMUaÿMYNKKWS]ÿOZÿWJLUWS]ÿOPÿJUNÿPILNaÿKWVMaÿJOS]\NÿOZÿJUZOIJaÿOZÿJZO\[KNÿ[ZNIJUWS]^
`
`8.9/7ÿ590B2/.Fÿlnpqrsmntÿ`I_ÿLI\MNÿUNIZJÿPIWK\ZNaÿYUWLUÿ`NISMÿ_O\ZÿUNIZJÿ`I_ÿSOJÿV\`VÿIMÿYNKKÿIMÿWJ
`MUO\KT^ÿsIKKÿ_O\ZÿUNIKJULIZNÿVZOXWTNZÿOZÿ]OÿJOÿJUNÿLKOMNMJÿN`NZ]NSL_ÿZOO`ÿPOZÿ`NTWLIKÿUNKVÿZW]UJÿIYI_
`WPÿ_O\ÿUIXNÿIS_ÿMW]SMÿOZÿM_`VJO`MÿM\LUÿIMÿMUOZJSNMMÿOPÿ[ZNIJUaÿIÿPIMJÿOZÿWZZN]\KIZÿUNIZJÿ[NIJaÿOZÿ\S\M\IK
`MYNKKWS]ÿWSÿ_O\Zÿ[OT_^
`
`;8.ÿe1-7ÿ61ee14ÿ-0@.ÿ.55.67-ÿ15ÿixyz{?jx|ÿ046B2@.:ÿ\VVNZÿZNMVWZIJOZ_ÿWSPNLJWOSaÿUNITILUNaÿISTÿKOY
`YUWJNÿ[KOOTÿLNKKÿLO\SJM^
`
`QUNMNÿIZNÿSOJÿIKKÿJUNÿVOMMW[KNÿMWTNÿNPPNLJMÿOPÿlnpqrsmnt^ÿsIKKÿ_O\ZÿTOLJOZÿPOZÿ`NTWLIKÿITXWLNÿI[O\JÿMWTN
`NPPNLJM^ÿwO\ÿ`I_ÿZNVOZJÿMWTNÿNPPNLJMÿJOÿHtnÿIJÿ}~~|x~}F
`
`kKNIMNÿMNNÿP\KKÿh/.-6/0v04Aÿ451/e97014i.@0697014ÿ20@.aÿWSLK\TWS]ÿ-./012-ÿ-0@.ÿ.55.67-aÿPOZÿITTWJWOSIK
` `VOZJISJÿoIPNJ_ÿ SPOZ`IJWOS^
`
`ÿ ÿ
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
` *
`
`
`
` ÿ ÿ
`
`
`
`
`
ÿÿÿ
ÿÿÿ ÿ
!
"ÿ#!
`
`-./012345ÿ78988ÿ:;1<=ÿ>?@ABÿC@1DE5@F5Bÿ?;1D@G0ÿ.1ÿ25Eÿ@HIJ2@5;EKÿAJJÿ12345Eÿ1;E;1L;FK
`
`M:CÿN;1.G.ÿ2Eÿ54;ÿO;@J54<@1;ÿPQE2G;EEÿ.Hÿ:;1<=ÿ>?@ABÿC@1DE5@F5Bÿ?;1D@G0ÿ2Gÿ54;ÿRKNKÿ@GFÿ-@G@F@K
`
`:ASMT-UACÿ@GFÿ:NÿU2H;U2G;Eÿ@1;ÿ1;32E5;1;Fÿ51@F;D@1=Eÿ.Hÿ:;1<=ÿ>?@ABÿC@1DE5@F5Bÿ?;1D@G0ÿ.1ÿ25Eÿ@HIJ2@5;EK
`
`M:CÿN;1.G.BÿVG<KBÿWG;ÿX;<4G.J.30ÿYJ@<;BÿZ.<=J@GFBÿ:Aÿ98[\9
`
`X42Eÿ];PE25;ÿ2Eÿ2G5;GF;Fÿ.GJ0ÿH.1ÿ1;E2F;G5Eÿ.Hÿ54;ÿRG25;FÿN5@5;EK
`
`RE;ÿ@GFÿ@<<;EEÿ.Hÿ542EÿE25;ÿ@1;ÿEQP^;<5ÿ5.ÿ54;ÿ5;1DEÿ@GFÿ<.GF252.GEÿE;5ÿ.Q5ÿ2Gÿÿ.Q1ÿ`abcdÿfÿghijklkhidÿ@GFÿmbknopqÿmhrkpqK
`
`stuv`wxyvzÿ{|}~~|~|
`
`mwg ÿmxwg
`
``uvÿfÿgxyw`wxyv
`
`gxxwuÿvu``wyv
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
`
`-./012345ÿ78988ÿ:;1<=ÿ>?@ABÿC@1DE5@F5Bÿ?;1D@G0ÿ.1ÿ25Eÿ@HIJ2@5;EKÿAJJÿ12345Eÿ1;E;1L;FK
`
`M:CÿN;1.G.ÿ2Eÿ54;ÿO;@J54<@1;ÿPQE2G;EEÿ.Hÿ:;1<=ÿ>?@ABÿC@1DE5@F5Bÿ?;1D@G0ÿ2Gÿ54;ÿRKNKÿ@GFÿ-@G@F@K
`
`:ASMT-UACÿ@GFÿ:NÿU2H;U2G;Eÿ@1;ÿ1;32E5;1;Fÿ51@F;D@1=Eÿ.Hÿ:;1<=ÿ>?@ABÿC@1DE5@F5Bÿ?;1D@G0ÿ.1ÿ25Eÿ@HIJ2@5;EK
`
`M:CÿN;1.G.BÿVG<KBÿWG;ÿX;<4G.J.30ÿYJ@<;BÿZ.<=J@GFBÿ:Aÿ98[\9
`
`X42Eÿ];PE25;ÿ2Eÿ2G5;GF;Fÿ.GJ0ÿH.1ÿ1;E2F;G5Eÿ.Hÿ54;ÿRG25;FÿN5@5;EK
`
`RE;ÿ@GFÿ@<<;EEÿ.Hÿ542EÿE25;ÿ@1;ÿEQP^;<5ÿ5.ÿ54;ÿ5;1DEÿ@GFÿ<.GF252.GEÿE;5ÿ.Q5ÿ2Gÿÿ.Q1ÿ`abcdÿfÿghijklkhidÿ@GFÿmbknopqÿmhrkpqK
`
`stuv`wxyvzÿ{|}~~|~|
`
`mwg ÿmxwg
`
``uvÿfÿgxyw`wxyv
`
`gxxwuÿvu``wyv
`
`$%&!' $ ' (&! ) ))* *$%&&&'+ '+$+&$,+ ,, ,'$+
`
`
`
`
Accessing this document will incur an additional charge of $.
After purchase, you can access this document again without charge.
Accept $ Charge
Still Working On It
This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.
Give it another minute or two to complete, and then try the refresh button.
A few More Minutes ... Still Working
It can take up to 5 minutes for us to download a document if the court servers are running slowly.
Thank you for your continued patience.
This document could not be displayed.
We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.
Your account does not support viewing this document.
You need a Paid Account to view this document. Click here to change your account type.
Your account does not support viewing this document.
Set your membership
status to view this document.
With a Docket Alarm membership, you'll
get a whole lot more, including:
- Up-to-date information for this case.
- Email alerts whenever there is an update.
- Full text search for other cases.
- Get email alerts whenever a new case matches your search.
One Moment Please
The filing “” is large (MB) and is being downloaded.
Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.
Your document is on its way!
If you do not receive the document in five minutes, contact support at support@docketalarm.com.
Sealed Document
We are unable to display this document, it may be under a court ordered seal.
If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.
Access Government Site
