From:
`To:
`Cc:
`
`Subject:
`Date:
`
`John West
`Richard Chen
`Russ B. Altman; Gemma Chandratillake; Russ Altman; Mark Pratt; Christian Haudenschild; Carol Tillis; Sarah
`Garcia
`Re: Name instead of "Exome+"
`Friday, January 11, 2013 6:00:01 PM
`
`This is good. While you all are on a roll, the new name for VariMed would be ___ ?
`
`John
`
`On Fri, Jan 11, 2013 at 5:10 PM, Richard Chen <richard.chen@personalis.com> wrote:
`We could use MINTdb as our new name for MendelDB, in that case MINT =
`Mendelian INheriTance DB
`
`On Fri, Jan 11, 2013 at 4:14 PM, Russ B. Altman
`<russ.altman@stanford.edu> wrote:
`> I won't push this hard because it's just an idea:
`
` Medically INTerpretable Genome = MINT Genome
`
`>>
`
`>>
`
` Medical = is what we do at 30K feet, e.g. we are not consumer. Research and care both
`are medical.
`
`>>
`
` Interpretable = we imply that we decide what is interpretable and we use genome because
`I think Exome is too limiting, and predict that MINT Genome will grow significantly
`(exclusively) over the years in the area of non-Exomic sequences.
`
` MINT = connotes new, fresh, accurate (coinage), green like our logo (minty fresh).
`
`>>
`
`>>
`
` MINT Genome v1.0 can be what we are doing now, and then we can have MINT Genome
`v2.0. I think we should move away from exome, because in light of ENCODE papers, and
`science movement in general (e.g. where variants are being found that matter) the exome is
`not as exciting. It is certainly included in the MINT Genome v1.0 but I don't think we
`should stress it.
`
`>>
`
` Of course, people will then read the details to understand exactly what we mean, but I like
`that this telegraphs our serious, accurate, fresh approach to medical genomics.
`
` That's it from me!
`
` Russ
`
`On Jan 11, 2013, at 1:41 PM, Gemma Chandratillake <gemmac@personalis.com> wrote:
`
`> Russ,
`>>
`>> Just a thought about names incorporating "medically interpretable"
`
`>>
`
`>>
`
`>>>
`
`>>
`
`Personalis EX2117.1
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`

`

`exome/genome.........I've heard people make reference to this sort of thing in conferences
`and they usually use it in the context of a subset of the exome/genome e.g. HGMD genes
`(since not all of it is currently considered medically interpretable) so I'm not sure whether it
`conveys greater coverage/content than standard exomes/genomes......it could sound like less
`coverage/content given the current common use of these terms.......
`>>
`>> Just a thought,
`>>
`>> Gemma
`>>
`>> On Fri, Jan 11, 2013 at 12:57 PM, Richard Chen <richard.chen@personalis.com> wrote:
`>> Ok, cc'ing Russ on this thread since he may have some fresh ideas :)
`>>
`>> On Fri, Jan 11, 2013 at 12:23 PM, John West <john.west@personalis.com> wrote:
`>> > I really like the ACE acronym. Can we fold in the "Accuracy" theme here in
`>> > addition to content / coverage ?
`>> > "Accuracy & Content Enhanced" exome / genome ?
`>> >
`>> > John
`>> >
`>> >
`>> > On Fri, Jan 11, 2013 at 11:53 AM, Gemma Chandratillake
`>> > <gemmac@personalis.com> wrote:
`>> >>
`>> >> In the context of exome, it's nice that the E in ACE can stand for exome
`>> >> but I agree with Mark that, taking a longer term view, if we go for ACE, it
`>> >> would be great to be able to use ACE in front of products generally and
`>> >> therefore E would need to stand for something other than exome.
`>> >>
`>> >> I'd also like to stay away from any "seq" references that everybody else
`>> >> is ripping of from Illumina.....
`>> >>
`>> >> Gemma
`>> >>
`>> >>
`>> >> On Fri, Jan 11, 2013 at 11:36 AM, Mark Pratt <mark.pratt@personalis.com>
`>> >> wrote:
`>> >>>
`>> >>> Great idea Rich. We need to make ACE work for the marketing value alone.
`>> >>> Further, we should define it in the prefix sense, eg ACE genome, ACE exome,
`>> >>> ACE panel, etc
`>> >>>
`>> >>>
`>> >>> Sent from my iPhone
`>> >>>
`>> >>> On Jan 11, 2013, at 11:10 AM, Richard Chen <richard.chen@personalis.com>
`>> >>> wrote:
`>> >>>
`>> >>> > Hi John, do you think that "medically supplemented exome" is too
`>> >>> > limiting in the sense that it more than just medical content (includes
`
`Personalis EX2117.2
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`

`

`>> >>> > regulatory regions, also increased coverage for existing exome)
`>> >>> >
`>> >>> > Other ideas are:
`>> >>> >
`>> >>> > Personalis Extended Exome
`>> >>> > Personalis Extended Clinical Exome
`>> >>> > Personalis Exome ACE (Personalis Exome with Augmented Coverage and
`>> >>> > Content Extensions)
`>> >>> > Personalis ACE Technology (ACE = Augmented Content and Coverage Exome)
`>> >>> >
`>> >>> >
`>> >>> > On Fri, Jan 11, 2013 at 10:35 AM, John West <john.west@personalis.com>
`>> >>> > wrote:
`>> >>> >>
`>> >>> >> All,
`>> >>> >>
`>> >>> >> We can't use "Exome+" as the name for our product as others already
`>> >>> >> use
`>> >>> >> this. Since we are now working to complete the content for our new
`>> >>> >> web
`>> >>> >> site, we need to address this. I tend to think of our product as a
`>> >>> >> "Medically Supplemented Exome". This is a bit of a mouthful, but it
`>> >>> >> does
`>> >>> >> get at the fact that our additions are focused on the two main
`>> >>> >> improvements
`>> >>> >> needed for medical use of an exome: Accuracy and Content (including
`>> >>> >> both
`>> >>> >> finished genes and content outside the exons). This would also set us
`>> >>> >> up to
`>> >>> >> later offer a "Medically Supplemented Genome". I did a quick Google
`>> >>> >> search
`>> >>> >> on these and did not find any hits.
`>> >>> >>
`>> >>> >> Any thoughts on this as a name, or alternatives you prefer ? I would
`>> >>> >> be
`>> >>> >> completely happy to have something more succinct, if any of us can
`>> >>> >> come up
`>> >>> >> with it.
`>> >>> >>
`>> >>> >> Thanks,
`>> >>> >>
`>> >>> >> John
`>> >>> >>
`>> >>> >>
`>> >>> >>
`>> >>> >>
`>> >>> >>
`>> >>
`>> >>
`>> >>
`
`Personalis EX2117.3
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`

`

`>> >>
`>> >> --
`>> >> Gemma Chandratillake, MPhil, PhD, MS, CGC
`>> >> Genomic Counselor, LGC
`>> >> Personalis, Inc.
`>> >
`>> >
`>>
`>>
`>>
`>> --
`>> Gemma Chandratillake, MPhil, PhD, MS, CGC
`>> Genomic Counselor, LGC
`>> Personalis, Inc.
`>
`
`Personalis EX2117.4
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`