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`CURRICULUM VITAE
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`Name
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`Henry Morrice Furneaux
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`Place of Birth Aberdeen, Scotland
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`Nationality
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`British
`U.S. Permanent Resident
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`Education
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`University of Aberdeen, Scotland, UK
`1970-75, B.Sc. (Honors in Biochemistry)
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`University of Aberdeen, Scotland, UK
`1975-78, Ph.D. Biochemistry
`Thesis: “An Examination of the Biological Role of ADP-Ribosylation”
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`Positions and Appointments
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`1979-1984
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`1984-1987
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`1987-1989
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`1989-1995
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`1989-1995
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`1996-2000
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`1996-2000
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`2000 -2009
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`Post Doctoral Fellow
`Dr. J. Hurwitz's Lab, Albert Einstein College of Medicine
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`Research Fellow
`Program in Molecular Biology, Sloan-Kettering Institute
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`Assistant Laboratory Member
`Program in Molecular Pharmacology and Therapeutics, Sloan-Kettering Institute
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`Assistant Member and Head of the Laboratory of Molecular Neuro-Oncology
`Sloan-Kettering Institute
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`Assistant Professor of Neuroscience
`Cornell University Graduate School of Medical Sciences
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`Associate Member and Head of the Laboratory of Molecular Neuro-Oncology
`Sloan-Kettering Institute
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`Associate Professor of Neuroscience
`Cornell University Graduate School of Medical Sciences
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`Associate Professor of Molecular, Microbial, and Structural Biology
`University of Connecticut School of Medicine
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`Personalis EX2010.001
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`2003-2009
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`2009-Present
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`Director of the Molecular Biology and Biochemistry Graduate Program,
`University of Connecticut School of Medicine
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`President and CEO of Clonegene LLC (http://www.clonegene.com/)
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`Clonegene designs, generates and distributes quality antibodies relevant to
`Virology and Oncology. These include high affinity monoclonal antibodies
`against Viral targets, Onco-Immune pathways, Gene expression regulators and
`Tumor neoantigens.
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`Patents
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`In collaboration with Cooper Dunham and White, involved in the application and successful award of
`the following patents:
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`• Posner JB and Furneaux HM. Antigen recognized by patients with antibody associated
`paraneoplastic sensory neuronopathy. February 1997, United States Patent No. 5,603,934.
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`• Posner JB, Darnell RB, and Furneaux HM. Ri fusion antigen recognized by antibodies
`associated with paraneoplastic opsoclonus and methods of use thereof. March 1997, United States
`Patent No. 5,614,371.
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`• Posner JB and Furneaux HM. Antigen recognized by patients with antibody associated
`paraneoplastic cerebellar degeneration, DNA encoding same and uses thereof. September 1997,
`United States Patent No. 5,668,013.
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`• Posner JB, Furneaux HM. Antigen recognized by patients with antibody associated
`paraneoplastic
`sensory neuronopathy, DNA encoding same and uses thereof. September 1998, United States
`Patent No. 5,807,705.
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`• Posner JB, Furneaux HM. Antigen recognized by patients with antibody associated cerebellar
`degeneration, DNA encoding same and uses thereof. July 1999, United States Patent No.
`5,925,526.
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`• Posner JB, Furneaux HM. Antigen recognized by patients with antibody associated
`paraneoplastic sensory neuropathy, DNA encoding same and uses thereof. February 2001, United
`States Patent No. 6,193,948.
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`Personalis EX2010.002
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` Membership of Scientific Societies and Honors
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`• Member of New York Academy of Science
`• The Harvey Society
`• The RNA Society
`• Holder of the Neil Levitan Chair in Neuro-Oncology (1998-2000).
`• Cited in “Who’s Who in America”
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`Teaching Experience
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`1990-2000
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`Designer and Director of the Molecular Basis of Neurological Disease – a course
`for MD/PhD students at Cornell University Graduate School of Medical Sciences
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`2001-2009
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`2001-2006
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`2002-2006
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`2003-2006
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`2003-2009
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`2006-2009
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`2007-2009
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`Designer and Director of the Molecular Basis of Disease, a graduate course for
`PhD and MD/PhD students at the University of Connecticut Medical School
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`Course Director of the Molecular Biology and Biochemistry Program Journal
`Club
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`Lecturer in Biochemistry I, a first-year biochemistry course for PhD students.
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`Lecturer in Organ Systems II, a first-year medical school course.
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`Outreach discovery lectures to encourage research careers for high school
`students.
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`Co-designed and taught in The Logic of Biology, a new discussion course for all
`incoming first year students to introduce them to experimental logic and
`contemporary problems in biology.
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`Lecturer in HB3, a first-year medical school course. Designed a new introductory
`module that combines the fields of vascular biology, hematology and
`immunology.
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`Major Academic Administrative Tasks
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`2003-2009
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`Director of the Graduate Program in Biochemistry and
`Molecular Biology
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`Personalis EX2010.003
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`2003-2009
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`The executive committee of the Dept of Molecular, Microbial
`and Structural Biology
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`2004
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`Graduate School Strategic Planning Committee
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`2004-2007
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`First year graduate student advisor
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`2005-2009
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`Scientific Advisory Committee – General Clinical Research Center
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`Federal Science Review Activities
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`Dept of Defense
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`2007
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`2009
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` Federal - NIH
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`Breast Cancer Research Program- Molecular Biology & Genetics Study
`Section
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`Breast Cancer Research Program - Molecular Biology & Genetics Study
`Section
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`KO8 - KO2 Awards –NHLBI Study Section
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`Oncological Sciences (F09) Study Section
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`October 2007
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`February 2008
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`June 2008
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`July 2008
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`June 2009 Oncological Sciences (F09) Study Section
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`Oncological Sciences (F09) Study Section
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`KO8 KO2 Awards –NHLBI Study Section
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`Editorial Work
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`• Editorial Advisor to editorial board of BMC Biochemistry
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`• Ad hoc reviewer for JBC, MCB, EMBO, Nucleic Acids Research, RNA, J Clinical Investigation
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`Funding
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`Past:
`ACS- EDT- 66404
`Paraneoplastic Neurological Syndromes
`1988-1992
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`Personalis EX2010.004
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`5
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`$485,000 total
`PI-Furneaux
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`NIH- R01-NS- 29682
`The structure and Function of Onco-Neural Antigens
`1991-1995
`$850,000 total
`PI-Furneaux
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`NSF- IBN- 9604175
`The Post-Transcriptional Regulation of GAP-43 expression
`1997-2000
`$280,380 total
`PI -Furneaux
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`Brain Tumor Society
`The regulation of VEGF expression in Brain Tumors
`1998-2000
`The Neil Levitan Chair in Neuro-Oncology
`$ 82,000 total
`PI-Furneaux
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`Burke Prostate Cancer Fund
`The expression of HuR in human tumors
`1998-2000
`$37,400 total
`PI- Furneaux
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`NIH RO1 HL58510
`Regulation of VEGF mRNA stability by hypoxia
`1999-2003
`$1,175,000
`PI- Furneaux
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`NIH P01 HL70694 -Program Project
`Sub project- Manipulation of Gene Expression
`The aim of this project is to investigate the structure and function of micro RNAs.
`2002-2007
`$375,000
`PI –Furneaux
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`Connecticut Department of Public Health
`DPH 2002
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`Personalis EX2010.005
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`6
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`The Development of Novel Cancer Therapeutics through the Application of siRNA Technology
`2002
`$25,000
`PI-Furneaux
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`Connecticut Department of Public Health - Tobacco Funds - Program Project Grant
`Project 3 examines potential mechanisms of smoking on fetal growth by examining placental
`pathology
`and HuR protein expression
`2006 - 2007
`$160,000
`PI –Furneaux
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`NIH R03 DA022226-01
`Cannabinoid Receptor (CNR1), microRNAs and addictive disease.
`Studies on variants in human mRNA that modulate microRNA regulation of behavioral genes.
`9/1/06 – 8/31/10
`$310,000 PI-Furneaux
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`Publications
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`1. Furneaux HM, Pearson CK: Properties of poly (ADP-ribose) polymerase from BHK cells.
`Biochem Soc. Trans, 5:743-745, 1977.
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`2. Furneaux HM, Pearson CK: The effects of NAD+ on RNA synthesis in isolated nuclei from BHK
`cells. Biochem Soc. Trans, 6:753-755, 1978.
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`3. Porteous JW, Furneaux HM, Lake CM: Poly (ADP-ribose) synthetase activity in nuclei of dividing
`and non-dividing but differentiating intestinal epithelial cells. Biochem J, 180: 455-463, 1979.
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`4. Furneaux HM, Pearson CK: Intracellular oxidized nicotinamide-adenine dinucleotide content and
`poly (adenosine diphosphate ribose) synthetase activity in serum-stimulated fibroblasts. Biochem Soc.
`Trans, 7: 697-699, 1979.
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`5. Furneaux HM, Pearson CK: Adenosine diphosphate ribose transferase from baby hamster kidney
`cells (CHK-21/C13). Biochem J, 187: 91-103, 1980.
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`6. Shuman S, Spencer E, Furneaux HM, Hurwitz J: The role of ATP in vitro vaccinia virus RNA
`synthesis. J Biol. Chem., 255: 5396-5403, 1980.
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`7. Furneaux HM, Pearson CK: Intracellular NAD content and ADP-ribose polymerase activity of
`serum stimulated BHK cells. J Cellular Physiology, 105: 401-408, 1980.
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`Personalis EX2010.006
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`8. Shuman S, Surks M, Furneaux HM, Hurwitz J: Purification and characterization of a GTP-
`pyrophosphate exchange activity from a vaccinia virus. J Biol. Chem. 255: 11588-11598,1980.
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`9. Furneaux HM, Pick L, Hurwitz J: Isolation and characterization of RNA ligase from wheat germ.
`Proc Natl. Acad. Sci, 80: 3933-3937, 1983.
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`10. Perkins KK, Furneaux HM, Hurwitz J: Isolation and characterization of RNA ligase from HeLa
`cells. Proc Natl. Acad. Sci, 82: 684-688, 1985.
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`11. Furneaux HM, Perkins KK, Freyer GA, Arenas J, Hurwitz J: Isolation and characterization of
`two fractions from HeLa cells required for mRNA splicing in vitro. Proc Natl. Acad. Sci, 82: 4351-
`4355, 1985.
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`12. Perkins KK, Furneaux HM, Hurwitz J: RNA splicing products formed with isolated fractions
`from HeLa cells are associated with fast-sedimenting complexes. Proc Natl. Acad. Sci, 83: 887-891,
`1986.
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`13. Pick L, Furneaux HM, Hurwitz J: Purification of wheat germ RNA ligase. J Biol. Chem., 261:
`6694-6704, 1986.
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`14. Perkins KK, Furneaux HM, Freyer GA, Arenas J, Pick L, Hurwitz J: Analysis of mRNA splicing
`using fractions isolated from HeLa cells and mutant adenovirus pre-mRNAs. In: Cancer Cells, Cold
`Spring Harbor Laboratory, 4: 247-258, 1986.
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`15. Freyer GA, Arenas J, Perkins KK, Furneaux HM, Pick L, Young B, Roberts R, Hurwitz J: In
`vitro formation of a lariat structure containing a G2-5G linkage. J Biol. Chem., 262: 4267-4273, 1987.
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`16. Furneaux HM, Dropcho EJ, Barbut D, Tseng-Chen Y, Rosenblum MK, Old LJ, Posner JB:
`Characterization of a cDNA encoding a 34 kD Purkinje neuron protein recognized by sera from
`patients with Paraneoplastic cerebellar degeneration. Proc Natl. Acad. Sci USA 86: 2873-2877, 1989.
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`17. Pruzan R, Furneaux HM, Lassota P, Hong GY, Hurwitz J: Assemblage of the pre-spliceosome
`complex with separated fractions isolated from HeLa cells. J Biol. Chem., 265: 2804-2813, 1990.
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`18. Kenny M, Schlegel U, Furneaux HM, Hurwitz J: The role of human single-stranded DNA
`binding protein and it's individual subunits in simian virus 40 DNA replication. J Biol. Chem., 265:
`7693-7700, 1990.
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`19. Furneaux HM, Reich L, Posner JB: Autoantibody synthesis in the central nervous system of
`patients with paraneoplastic syndromes. Neurology, 40: 1085-1091, 1990.
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`20. Dalmau J, Furneaux HM, Gralla RJ, Kris MG, Posner JB: Detection of the anti-Hu antibody in
`the serum of patients with small cell lung cancer, a quantitative Western blot analysis. Ann Neurol,
`27: 544-552, 1990.
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`Personalis EX2010.007
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`21. Furneaux HM, Rosenblum MK, Dalmau J, Wong E, Woodruff P, Posner JB: Selective
`expression of Purkinje cell antigens in tumor tissue from patients with paraneoplastic cerebellar
`degeneration. N Eng. J Med., 322: 1844-51, 1990.
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`22. Pick L, Furneaux HM, Hurwitz J: Purification and characterization of wheat germ ligase
`and associated activities. Methods in Enzymology, 181: 18-36, 1990.
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`23. Posner JB, Furneaux HM: Paraneoplastic neurological syndromes. Proc Ass Res. Nerv
`Men Dis, 68: 187-219, 1990.
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`24. Schlegel U, Moots PL, Rosenblum MK, Thaler HT, Furneaux HM: Expression of transforming
`growth factor alpha in human gliomas. Oncogene, 5: 1839-1842, 1990.
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`25. Luque FA, Furneaux HM, Wray SH, Schold SC, Glanz MJ, Jaeckle KA, Biran H, Lesser M,
`Paulson WA, River ME, Posner JB: Anti-Ri: An antibody associated with paraneoplastic opsoclonus
`and breast cancer. Annals Neurology, 29: 241-251, 1991.
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`26. Darnell RB, Furneaux HM, Posner JB: Antiserum from a patient with cerebellar degeneration
`identifies a novel protein in Purkinje cells, cortical neurons and neuroectodermal tumors. J
`Neuroscience, 11: 1224-1230, 1991.
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`27. Fathallah-Shaykh H, Wolf S, Wong E, Posner JB, Furneaux HM: Cloning of a leucine zipper
`protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar
`degeneration. Proc Nat Acad. Sci, 88: 3451-3454, 1991.
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`28. Siniscalco M, Obele I, Melis P, Alhadeff B, Murray J, Filippi G, Nationi T, Chen Y-T, Furneaux
`HM, Old LJ, Posner JB: Physical and genetic mapping of the CDR gene with particular reference to
`its position with respect to the FRAXA site. Am J Med. Genetics, 38: 357-362, 1991.
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`29. Dalmau J, Furneaux HM, Rosenblum M, Graus F, Posner JB: Detection of the anti-Hu antibody
`in specific regions of the nervous system and tumor from patients with paraneoplastic
`encephalomyelitis/sensory neuronopathy. Neurology 41: 1757-1764, 1991.
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`30. Szabo A, Dalmau J, Manley G, Rosenfeld M, Wong E, Henson J, Posner JB, Furneaux HM: HuD
`a paraneoplastic encephalomyelitis antigen contains RNA binding domains and is homologous to Elav
`and Sex-Lethal. Cell 67: 325-333, 1991.
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`31. Henson J, Rosenblum M, Armstrong D, Furneaux H: Amplification of JC virus DNA from brain
`and cerebrospinal fluid of patients with progressive multifocall eucoencephalopathy. Neurology 41:
`1967-1971, 1991.
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`32. Henson J, Saffer J, Furneaux H: The transcription factor Sp1 binds to the JC virus promotor and
`is selectively expressed in glial cells in human brain. Annals of Neurology 32: 72-77, 1992.
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`Personalis EX2010.008
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`33. Gress T, Baldini A, Rocchi M, Furneaux HM, Posner JB, Siniscalco M: In situ mapping of the
`gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1. Genomics 13:
`1340-1342, 1992.
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`34. Schlegel U, Rosenfeld M, Voldanandt M, Rosenblum M, Furneaux HM: p53 Mutations in
`primary lung tumors are conserved in brain metastasis. J Neuro-Oncology 14: 93-100, 1992.
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`35. DeAngelis LM, Wong E, Rosenblum M, Furneaux H: Epstein-Barr virus in AIDS and non-AIDS
`primary central nervous system lymphoma. Cancer 70: 1607-1611, 1992.
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`36. Dalmau J, Furneaux HM, Cordon-Cardo C and Posner JB. The expression of the Hu
`(paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues.
`Am J Path 141(4): 1-6, 1992.
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`37. Rosenfeld M, Wong E, Dalmau J, Manley G, Egan D, Posner JB, Sher E, Furneaux HM: Sera
`from patients with Lambert-Eaton myasthenic syndrome recognize the b subunit of Ca++ channel
`complexes. Ann NY Acad. Sci 681: 408-412, 1993.
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`38. Rosenfeld M, Wong, E, Dalmau, J, Manley, G, Posner JB, Sher E, Furneaux HM: The cloning
`and characterization of a Lambert-Eaton myasthenic syndrome antigen. Ann Neurol 33: 113-120,
`1993.
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`39. Marusich HM, Furneaux HM, Henion P, and Weston JA: Hu neuronal proteins are expressed in
`proliferating neurogenic cells. J Neurobiol 25: 143-155, 1994.
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`40. Manley G, Wong E, Dalmau J, Elkon K, Posner J and Furneaux H. Sera from some patients with
`antibody-associated paraneoplastic encephalomyelitis recognize the Ro-52K antigen. J Neuro Onc
`19:105-112, 1994.
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`41. Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM and Siniscalco M. Mapping of the gene
`coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34
`Cytogenetics and Cell Genetics 65:177-178, 1994.
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`42. Liu J, Dalmau J, Szabo A, Rosenfeld M, Huber J, and Furneaux HM*. Paraneoplastic
`encephalomyelitis antigens bind to the AU-rich elements of mRNA. Neurology 45:544-550, 1995.
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`43. Barami K, Iversen K, Furneaux HM, and Goldman SA. Hu protein as an early marker of
`neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain. J.
`Neurobiology 28:82-101, 1995.
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`44. Chung S, Jiang L, Cheng S, and Furneaux HM*. Purification and properties of HuD, a neuronal
`RNA binding protein. J. Biol. Chem. 271:11518-11524, 1996.
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`45. Furneaux HM . Neuronal nuclear auto antibodies, Type 1 (Hu), in Auto antibodies, J.B.
`Peter and Y. Shoenfeld, Editors.1996, Elsevier Science B.V.: Amsterdam. p. 551-554.
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`Personalis EX2010.009
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`46. Ma W-J, Cheng S, Wright A, Campbell C and Furneaux HM*. Cloning and characterization of
`HuR, a ubiquitously expressed Elav-like protein. J. Biol. Chem. 271:8144-8151, 1996.
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`47. Ma W-J, Furneaux HM*. Localization of the human HuR gene to chromosome 19p13.2. Hum
`Genet 99:32-33, 1997.
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`48. Ma W-J, Chung S and Furneaux HM*. The elav-like proteins bind to AU-rich elements and the
`poly (A) tail of mRNA. Nuc. Acid Res. 25: (18) 3564-3569, 1997.
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`49. Chung S, Eckrich, M, Perrone-Bizzozero N, Kohn DT, Furneaux HM*. The Elav-like proteins
`bind to a conserved regulatory element in the 3' UTR of GAP-43 mRNA. J. Biol. Chem. 272:6593-
`6598, 1997.
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`50. Levy NS, Chung S, Furneaux HM, and Levy AP. Hypoxic stabilization of VEGF mRNA by the
`RNA-binding protein HuR. J. Biol. Chem., 273:6417-6423, 1998.
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`51. Joseph B, Orlian M, and Furneaux HM*. p21waf1 mRNA contains a conserved element in its
`3{prime}-untranslated region that is bound by the Elav-like mRNA-stabilizing proteins. J. Biol.
`Chem., 273:20511-20517, 1998.
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`52. Joseph B. and Furneaux HM. cDNA Libraries and Neurological Disease. Arch.
`Neurol., 55(6): 785-788, 1998.
`53. Nabors LB, Furneaux HM, King PH. HuR, a novel target of anti-Hu antibodies, is expressed in
`non-neural tissues. J. Neuroimmunol. 92:152-159, 1998.
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`54. Sokolowski M, Furneaux HM, and Schwartz S. The inhibitory activity of the AU-rich element in
`the human papillomavirus type 1 late 3' untranslated region correlates with its affinity for the elav-like
`HuR protein. J. Virology, 73:1080-1091, 1999.
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`55. Aranda-Abreu GE, Behar L, Chung S, Furneaux H, and Ginzburg I. Embryonic Lethal Abnormal
`Vision-Like RNA-Binding Proteins Regulates Neurite Outgrowth and Tau Expression in PC12 Cells.
`J. Neuroscience 19:6907-6917, 1999.
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`56. Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N, and Gorospe M.
`HuR regulates p21 mRNA stabilization by UV light Mol. Cell. Biol. 20: 760-9, 2000.
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`57. Haeussler J, Haeusler J, Striebel AM, Assum G, Vogel W, Furneaux H, Krone W. Tumor
`Antigen HuR Binds Specifically to One of Five Protein-Binding Segments in the 3'-Untranslated
`Region of the Neurofibromin Messenger RNA. Biochem Biophys Res. Commun 267:726-732, 2000.
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`58. Wang W, Caldwell MC, Lin S, Furneaux H and Gorospe M. HuR regulates Cyclin
`and Cyclin B1 mRNA Stability during Cell Proliferation. EMBO 19:2340-50, 2000.
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`Personalis EX2010.010
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`59. Mobarak CD, Anderson KD, Beckel-Mitchener A, Furneaux H, and Perrone-Bizzozero NI. The
`RNA-binding protein HuD induces neurite outgrowth in PC12Cells. Mol Biol. Cell 11:3191-203,
`2000.
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`60. Zhao Z, and Furneaux H.M. The Identification of an mRNA endonuclease that cleaves within
`the HuR binding site of p27kip1 mRNA. Nucleic Acids Res 28:2695-701, 2000.
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`61. Anderson KD, Morin MA, Beckel-Mitchener A, Mobarak CD, Neve RL, Furneaux H, Burry R,
`Perrone-Bizzozero NI. Overexpression of HuD, but not of its truncated form HuD I+II, promotes
`GAP-43
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`62. Rodriguez-Pascual F, Hausding M, Ihrig-Biedert I, Furneaux H, Levy AP, Forstermann
`U, Kleinert H. Complex contribution of the 3'-untranslated region to the expressional
`regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-
`binding protein HuR. J Biol. Chem.275: 26040-9, 2000
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`63. Di Marco S, Hel Z, Lachance C, Furneaux H, Radzioch D. Polymorphism in the 3'
`untranslated region of TNFalpha mRNA impairs binding of the post-transcriptional
`regulatory protein HuR to TNFalpha mRNA. Nucleic Acids Res. 29:863-871, 2001.
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`64. Ana Cuadrado, Cristina Navarro-Yubero, Henry Furneaux, Jochen Kinter, Peter
`Sonderegger and Alberto Muñoz. HuD binds to three AU-rich sequences in the 3'-UTR of
`neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein Nuc
`Acid Res. 30: 2202-2211, 2002.
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`65. B. B. Yeap, Dominic Voon, Julian Vivian, Ross McCullock, Andrew M. Thomson, Maria
`F. Czyzyk-Krzeska, Henry Furneaux, Matthew C. Wilce, Jackie Wilce and Peter J.
`Leedman. Novel Cooperative Binding of HuR and Poly C Binding Protein to a Conserved
`UC-rich Motif within the 3' Untranslated Region of the Androgen Receptor messenger RNA,
`J. Biol. Chem., Vol. 277; 30, 27183-27192, 2002
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`66. Goldberg-Cohen I, Furneaux H, Levy AP. A 40-bp RNA element that mediates
`stabilization of vascular endothelial growth factor mRNA by HuR. J Biol Chem. 2002 Apr
`19;277(16):13635-40.
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`67. Giles, K.M., Daly, J.M., Beveridge, D.J., Voon, D.C., Thomson, A.M., Furneaux, H.M.,
`Jazayeri, J.A., and Leedman, P.J. The 3"-UTR of p21WAF1 mRNA is a complex cis-acting
`element bound by multiple RNA-binding proteins from breast cancer cells, including HuR,
`poly(C)-binding protein (CP1) and poly (A)-binding protein, J Biol Chem. 2003 Jan
`31;278(5):2937-46. Epub 2002 Nov 12.
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`68. Kloess, SW., Furneaux, H., and Mülsch, A. Posttranscriptional regulation of soluble
`guanylylcyclase expression in rat aorta. J. Biol. Chem. 2002
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`69. Sengupta, S., Jang B.C. Wu, M-T., Paik, J-H, Furneaux, H. and Hla T. “The RNA
`binding protein HuR regulates the expression of Cyclooxygenase-2” JBC (2003) Vol. 278
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`Personalis EX2010.011
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`70. Ana Cuadrado,* Cristina Navarro-Yubero,* Henry Furneaux, † and Alberto Muñoz
`“Neuronal HuD gene encoding an mRNA stability regulator is transcriptionally repressed by
`thyroid hormone” J. Neurochem (2003) 86(3):763-73.
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`12
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`71. Bogdan, C.A., Alexander, A.A., Gorny, M.K., Matute, R., Marjanovic, N.,Zolla-Pazner,
`S., Walden, P.D., Furneaux, H.M., Sidhu, G.S., and Jacobson, D.R. “Chronic Lymphocytic
`Leukemia with Prostate Infiltration Mediated by Specific Clonal Membrane-bound IgM1”
`Cancer Res. (2003) 63: 2067-2071
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`72. Erkinheimo TL, Lassus H, Sivula A, Sengupta S, Furneaux H, Hla T, Haglund C,
`Butzow R, Ristimaki A.Cytoplasmic HuR expression correlates with poor outcome and with
`cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res. 2003 Nov 15;
`63(22):7591-4.
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`73. Chae SS, Paik JH, Furneaux H, Hla T.,Requirement for sphingosine 1-phosphate
`receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin. Invest.
`2004 Oct; 114(8):1082-9.
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`74. Smith CL, Afroz R, Bassell GJ, Furneaux HM, Perrone-Bizzozero NI, Burry RW.GAP-
`43 mRNA in growth cones is associated with HuD and ribosomes. J. Neurobiol. 2004 Nov;
`61(2):222-35.
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`75. Sung-Suk Chae, Ji-Hye Paik, Jonathan Schubert-Coleman, Henry Furneaux, Timothy
`Hla: Application of the RNA Interference (RNAi) Technology to Angiogenesis Research.
`H. Augustin (Ed.), 2004, Methods in Endothelial Cell Biology - Springer Lab
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`76. Heinonen M, Bono P, Narko K, Chang SH, Lundin J, Joensuu H, Furneaux H, Hla T,
`Haglund C, Ristimaki A.Cytoplasmic HuR expression is a prognostic factor in invasive
`ductal breast carcinoma. Cancer Res. 2005 Mar 15; 65(6):2157-61
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`77. Erkinheimo TL, Sivula A, Lassus H, Heinonen M, Furneaux H, Haglund C, Butzow R,
`Ristimaki A. Related Articles, Links Cytoplasmic HuR expression correlates with epithelial
`cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian
`carcinoma. Gynecol Oncol. 2005 Oct; 99(1):14-9.
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`78. Abdelmohsen K., Pullmann R., Jr., Lal, A., Kim, HH. Galban,S., Yang, X., Blethrow,J,,
`Shubert J., Gillespie, DA, Furneaux H. and Gorospe, M., Regulation of SIRT1 Expression
`by RNA-Binding Protein HuR: Role of Checkpoint Kinase Chk2 Molecular Cell,
`;25(4):543-57, 2007
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`79. Adams, BD, Furneaux H, White, B. The micro-RNA miR-206 Targets the Human
`Estrogen Receptor-{alpha}, and Represses ER {alpha} mRNA and Protein Expression in
`Breast Cancer Cell Lines. Molecular Endocrinology May; 21(5):1132-47, 2007
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`80. Salzman DW, Shubert-Coleman J, Furneaux H. P68 RNA helicase unwinds the human
`let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene
`expression. J Biol Chem. 2007 Nov 9;282(45):32773-9
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`81. Chakrabarty A, Tranguch S, Daikoku T, Jensen K, Furneaux H., Dey SK. MicroRNA
`regulation of cyclooxygenase-2 during embryo implantation Proc Natl Acad Sci USA. 2007
`;104(38):15144-9
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`82. Jensen KP, Covault J, Conner TS, Tennen H, Kranzler HR, Furneaux HM. A common
`polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and
`associates with aggressive human behaviors. Molecular Psychiatry 2009 14(4):381-9
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`83. Felice KM, Salzman DW, Shubert-Coleman J, Jensen KP, Furneaux HM. The 5' terminal
`uracil of let-7a is critical for the recruitment of mRNA to Argonaute2. Biochem J. 2009 Aug
`13;422(2):329-41
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`84. Conner TS, Jensen KP, Tennen H, Furneaux HM, Kranzler HR, Covault J.Functional
`polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and
`hostility among young men. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan
`5;153B(1):67-78.
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`85. Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C,
`Furneaux H, Hla T.Essential role of the RNA-binding protein HuR in progenitor cell survival
`in mice. J Clin Invest. 2009 Dec;119(12):3530-43.
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`Personalis EX2010.013
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