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`Case No.: IPR2023-00206
`U.S. Patent No. 9,943,096
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`UNITED STATES PATENT AND TRADEMARK OFFICE
`____________
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`____________
`
`MOTIF FOODWORKS, INC.,
`
`Petitioner,
`
`v.
`
`IMPOSSIBLE FOODS INC.,
`Patent Owner.
`____________
`
`____________
`
`Case No.: IPR2023-00206
`U.S. Patent No. 9,943,096
`____________
`
`
`
`DECLARATION OF DR. TARTÉ
`IN SUPPORT OF PETITION FOR INTER PARTES REVIEW
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`
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`TABLE OF CONTENTS
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`Case No.: IPR2023-00206
`U.S. Patent No. 9,943,096
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`Page
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`V.
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`INTRODUCTION ........................................................................................... 1
`I.
`QUALIFICATIONS ........................................................................................ 2
`II.
`SCOPE OF ASSIGNMENT ............................................................................ 5
`III.
`IV. LEGAL UNDERSTANDING ......................................................................... 7
`Person of Ordinary Skill in the Art ....................................................... 7
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`Claim Construction ............................................................................... 8
`Anticipation ........................................................................................... 9
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` Obviousness ......................................................................................... 10
`Product-by-process Claims ................................................................. 11
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` Written Description ............................................................................. 12
`THE ’096 PATENT ....................................................................................... 13
`Level of Ordinary Skill In The Art ..................................................... 13
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`Claims .................................................................................................. 13
`Specification ........................................................................................ 14
`Prosecution History for the ’096 Patent .............................................. 14
`Priority Date of the ’096 Claims ......................................................... 18
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`VI. CHALLENGED CLAIMS ............................................................................ 19
`VII. STATE OF THE ART ................................................................................... 24
`Benefits of Artificial Meat Flavor Additives and Meat
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`Substitutes ........................................................................................... 24
`1. Meat Consumption .................................................................... 24
`2.
`Health ........................................................................................ 25
`3.
`Environment .............................................................................. 26
`4.
`Animal Welfare ......................................................................... 27
`Attributes of Meat ............................................................................... 28
`1.
`Nutritional Content of Meat ...................................................... 28
`2.
`Color of Meat ............................................................................ 31
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`3.
`Non-animal Heme-Containing Proteins .................................... 33
`Recombinant Technology ................................................................... 35
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` Meat Flavor Chemistry ........................................................................ 37
`VIII. SUMMARY OF THE PRIOR ART .............................................................. 37
`“Brown” – EX1012 ............................................................................. 37
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`“MacLeod” – EX1024 ......................................................................... 40
`“Giacino” – EX1015 ........................................................................... 41
`“Conrad” – EX1013 ............................................................................ 42
`“Crane” – EX1014............................................................................... 42
`“Perret” – EX1020............................................................................... 43
`“Proulx” – EX1019 ............................................................................. 44
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`IX. SUMMARY OF OPINIONS ......................................................................... 45
`X.
`CLAIM CONSTRUCTION .......................................................................... 48
`“contains no animal products” ............................................................ 48
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`“food flavor additive composition” ..................................................... 49
`“a compound” ...................................................................................... 51
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`XI. GROUND 1: BROWN (ANTICIPATION) .................................................. 51
`Claim 1 ................................................................................................ 51
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`1.
`1[pre]: A food flavor additive composition comprising: .......... 52
`2.
`1[a]: a) an isolated heme-containing protein ............................ 54
`3.
`1[b]: b) a compound selected from glucose, ribose,
`fructose, lactose, xylose, arabinose, glucose-6-phosphate,
`maltose, maltodextrin, and galactose, and mixtures of two
`or more thereof; and .................................................................. 56
`1[c]: c) a compound selected from cysteine, cystine,
`thiamine, methionine, and mixtures of two or more
`thereof; ...................................................................................... 56
`1[d]: wherein the flavor additive composition contains no
`animal products; and ................................................................. 59
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`U.S. Patent No. 9,943,096
`food
`flavor additive
`the
`1[e]: wherein cooking
`composition results in the production of at least two
`volatile compounds which have a meat-associated aroma. ...... 60
`Claim 2 ................................................................................................ 61
`Claim 3 ................................................................................................ 62
`Claims 4 and 24 ................................................................................... 66
`Claim 5 ................................................................................................ 67
`Claim 7 ................................................................................................ 67
`Claim 8 ................................................................................................ 71
`Claim 9 ................................................................................................ 72
`Claim 23 .............................................................................................. 73
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`XII. GROUNDS 2A, 2B: GIACINO, BROWN, MACLEOD ............................. 74
` Giacino and Brown Are Analogous Art .............................................. 74
`A POSITA Would Have Been Motivated to Combine Giacino
`
`and Brown ........................................................................................... 75
`1.
`Lipid Oxidation ......................................................................... 77
`A POSITA Would Have Had a Reasonable Expectation of
`Success When Combining Giacino and Brown .................................. 79
`Claim 1 ................................................................................................ 80
`1.
`1[pre]: A food flavor additive composition comprising: .......... 80
`2.
`1[a]: a) an isolated heme-containing protein ............................ 81
`3.
`1[b]: b) a compound selected from glucose, ribose,
`fructose, lactose, xylose, arabinose, glucose-6-phosphate,
`maltose, maltodextrin, and galactose, and mixtures of two
`or more thereof; and .................................................................. 86
`1[c]: c) a compound selected from cysteine, cystine, thiamine,
`methionine, and mixtures of two or more thereof; ................... 86
`1[d]: wherein the flavor additive composition contains no
`animal products; and ................................................................. 87
`1[e]: wherein cooking
`the
`food
`flavor additive
`composition results in the production of at least two
`volatile compounds which have a meat-associated aroma. ...... 90
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`Claims 2 and 15 ................................................................................... 93
`Claims 3 and 16 ................................................................................... 94
`Claims 4 and 24 ................................................................................... 94
`Claim 5 ................................................................................................ 96
`Claims 6 and 22 ................................................................................... 96
`Claim 7 ................................................................................................ 97
`Claims 8 and 17 ................................................................................... 98
`Claims 9 and 22 ................................................................................... 99
` Claim 10 ............................................................................................ 101
`1.
`10[pre]: A food flavor additive composition prepared by a
`process of: ............................................................................... 101
`10[a]: a) combining an isolated heme-containing protein; ..... 101
`10[b]: a compound selected from glucose, ribose, fructose,
`lactose, xylose, arabinose, glucose-6-phosphate, maltose
`and galactose, and mixtures of two or more thereof; and ....... 102
`10[c]: a compound selected from cysteine, cystine, thiamine,
`methionine, and mixtures of two or more thereof, to form
`a heme flavor reaction mixture, and ....................................... 102
`10[d]: b) heating the heme flavor reaction mixture to at
`least 150° C. for at least 1 minute to result in the food
`flavor additive composition; ................................................... 102
`10[e]: wherein the food flavoring additive composition
`contains no animal products; and ............................................ 103
`10[f]: wherein the heme flavor reaction mixture has a
`meaty flavor and/or meaty aroma during the heating of
`step b) and the food flavoring additive composition has a
`meaty flavor and/or meaty aroma after the heating of step
`b). ............................................................................................ 103
`Claim 11 ............................................................................................ 104
`Claim 12 ............................................................................................ 106
`Claim 14 ............................................................................................ 106
`Claim 18 ............................................................................................ 108
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`2.
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`Claim 19 ............................................................................................ 111
`Claims 20, 21 ..................................................................................... 113
`Claim 23 ............................................................................................ 114
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`XIII. GROUNDS 3A, 3B, 3C, 3D: GIACINO, CONRAD, CRANE,
`PROULX, PERRET, MACLEOD .............................................................. 116
` Giacino, Conrad, and Crane Are Analogous Art .............................. 116
`A POSITA Would Have Been Motivated to Combine Giacino,
`
`Conrad, and Crane ............................................................................. 118
`1.
`Lipid Oxidation ....................................................................... 123
`A POSITA Would Have Had a Reasonable Expectation of
`Success When Combining Giacino, Conrad, and Crane ................... 123
`Claim 1 .............................................................................................. 125
`1.
`1[pre]: A food flavor additive composition comprising: ........ 125
`2.
`1[a]: a) an isolated heme-containing protein .......................... 125
`3.
`1[b]: b) a compound selected from glucose, ribose,
`fructose, lactose, xylose, arabinose, glucose-6-phosphate,
`maltose, maltodextrin, and galactose, and mixtures of two
`or more thereof; and ................................................................ 130
`1[c]: c) a compound selected from cysteine, cystine, thiamine,
`methionine, and mixtures of two or more thereof; ................. 131
`1[d]: wherein the flavor additive composition contains no
`animal products; and ............................................................... 131
`1[e]: wherein cooking
`the
`food
`flavor additive
`composition results in the production of at least two
`volatile compounds which have a meat-associated aroma. .... 132
`Claims 2 and 15 ................................................................................. 133
`Claims 3 and 16 ................................................................................. 133
`Claims 4 and 24 ................................................................................. 135
`Claim 5 .............................................................................................. 135
`Claims 6 and 22 ................................................................................. 136
`Claim 7 .............................................................................................. 136
`Claims 8 and 17 ................................................................................. 136
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`Claims 9 and 22 ................................................................................. 138
` Claim 10 ............................................................................................ 138
`1.
`10[pre]: A food flavor additive composition prepared by a
`process of: ............................................................................... 138
`10[a]: a) combining an isolated heme-containing protein; ..... 138
`10[b]: a compound selected from glucose, ribose, fructose,
`lactose, xylose, arabinose, glucose-6-phosphate, maltose
`and galactose, and mixtures of two or more thereof; and ....... 138
`10[c]: a compound selected from cysteine, cystine,
`thiamine, methionine, and mixtures of two or more
`thereof, to form a heme flavor reaction mixture, and ............. 138
`10[d]: b) heating the heme flavor reaction mixture to at
`least 150° C. for at least 1 minute to result in the food
`flavor additive composition; ................................................... 139
`10[e]: wherein the food flavoring additive composition
`contains no animal products; and ............................................ 139
`10[f]: wherein the heme flavor reaction mixture has a
`meaty flavor and/or meaty aroma during the heating of
`step b) and the food flavoring additive composition has a
`meaty flavor and/or meaty aroma after the heating of step
`b). ............................................................................................ 139
`Claim 11 ............................................................................................ 140
`Claim 12 ............................................................................................ 141
`Claim 14 ............................................................................................ 142
`Claim 18 ............................................................................................ 149
`Claim 19 ............................................................................................ 151
`Claims 20, 21 ..................................................................................... 153
`Claim 23 ............................................................................................ 153
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`XIV. GROUNDS 4A, 4B, 4C: GIACINO, PROULX, CONRAD, PERRET,
`MACLEOD .................................................................................................. 153
` Giacino, Proulx, and Conrad Are All Analogous Art ....................... 153
`A POSITA Would Have Been Motivated to Combine Giacino,
`
`Proulx, and Conrad to Achieve the Claimed Subject Matter ............ 155
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`1.
`Lipid Oxidation ....................................................................... 161
`A POSITA Would Have Had a Reasonable Expectation of
`Success When Combining Giacino, Proulx, and Conrad .................. 161
`Claim 1 .............................................................................................. 162
`1.
`1[pre]: A food flavor additive composition comprising: ........ 163
`2.
`1[a]: a) an isolated heme-containing protein .......................... 163
`3.
`1[b]: b) a compound selected from glucose, ribose,
`fructose, lactose, xylose, arabinose, glucose-6-phosphate,
`maltose, maltodextrin, and galactose, and mixtures of two
`or more thereof; and ................................................................ 167
`1[c]: c) a compound selected from cysteine, cystine, thiamine,
`methionine, and mixtures of two or more thereof; ................. 168
`1[d]: wherein the flavor additive composition contains no
`animal products; and ............................................................... 168
`1[e]: wherein cooking
`the
`food
`flavor additive
`composition results in the production of at least two
`volatile compounds which have a meat-associated aroma. .... 168
`Claims 2 and 15 ................................................................................. 169
`Claims 3 and 16 ................................................................................. 170
`Claims 4 and 24 ................................................................................. 170
`Claim 5 .............................................................................................. 170
`Claims 6 and 22 ................................................................................. 171
`Claim 7 .............................................................................................. 171
`Claims 8 and 17 ................................................................................. 171
`Claims 9 and 22 ................................................................................. 171
` Claim 10 ............................................................................................ 171
`1.
`10[pre]: A food flavor additive composition prepared by a
`process of: ............................................................................... 172
`10[a]: a) combining an isolated heme-containing protein; ..... 172
`10[b]: a compound selected from glucose, ribose, fructose,
`lactose, xylose, arabinose, glucose-6-phosphate, maltose
`and galactose, and mixtures of two or more thereof; and ....... 172
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`10[c]: a compound selected from cysteine, cystine, thiamine,
`methionine, and mixtures of two or more thereof, to form
`a heme flavor reaction mixture, and ....................................... 172
`10[d]: b) heating the heme flavor reaction mixture to at
`least 150° C. for at least 1 minute to result in the food
`flavor additive composition; ................................................... 173
`10[e]: wherein the food flavoring additive composition
`contains no animal products; and ............................................ 173
`10[f]: wherein the heme flavor reaction mixture has a
`meaty flavor and/or meaty aroma during the heating of
`step b) and the food flavoring additive composition has a
`meaty flavor and/or meaty aroma after the heating of step
`b). ............................................................................................ 173
`Claim 11 ............................................................................................ 174
`Claim 12 ............................................................................................ 175
`Claim 14 ............................................................................................ 176
`Claims 18 and 19 ............................................................................... 177
`Claims 20, 21, 23 ............................................................................... 177
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`XV. CONCLUSION ............................................................................................ 177
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`Case No.: IPR2023-00206
`U.S. Patent No. 9,943,096
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`I, Rodrigo Tarté, Ph.D., declare as follows:
`
`I.
`
`INTRODUCTION
`1.
`I have been retained by Quinn Emanuel Urquhart & Sullivan LLP on
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`behalf of Motif FoodWorks, Inc. (“Petitioner” or “Motif”) as an independent expert
`
`in this inter partes review (“IPR”) proceeding which is pending before the Patent
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`Trial and Appeal Board (“the Board”) of the United States Patent and Trademark
`
`Office (the “Proceeding”). I understand that, in this Proceeding, Motif is challenging
`
`the validity of claims 1-12 and 14-24 (the “Challenged Claims”) of U.S. Patent No.
`
`9,943,096 (the “’096 patent”). Based on the first page of the ’096 patent, I
`
`understand it to be assigned to Impossible Foods Inc. (“Patent Owner”).
`
`2.
`
`I have been asked by Motif to provide my opinions regarding the
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`validity of the ’096 patent claims in this declaration (“Declaration”).
`
`3.
`
`I am informed that the ’096 patent has been asserted by Patent Owner
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`against Motif in the co-pending litigation Impossible Foods Inc. v. Motif FoodWorks,
`
`Inc., Case No. 22-cv-311 (D. Del.) (“Litigation”). I understand that the Litigation is
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`proceeding in the District Court for the District of Delaware (“District Court”).
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`4.
`
`I understand that, in the Litigation, neither party has exchanged any
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`contentions relating to infringement (or non-infringement) or invalidity (or validity),
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`and that neither party has yet proposed any claim constructions. I further understand
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`that the District Court has not been yet asked to construe any claims of the ’096
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`patent and that no claim construction order has been issued. I also understand that
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`Patent Owner has not filed any motions seeking injunctive relief and the District
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`Court likely will not order claim construction briefing or a hearing until a later point
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`in the Litigation. Lastly, I understand that the ’096 patent has not been previously
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`asserted in any litigation nor subject to any prior post-grant proceeding to review its
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`validity against the prior art. I reserve the right to amend or supplement my opinions
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`in this Declaration in response to any positions that Patent Owner may take in the
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`Litigation, or in response to any order of the District Court.
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`II. QUALIFICATIONS
`5.
`Exhibit 1004 accompanying this Declaration is a true and correct copy
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`of my current CV. It describes in greater detail my education, publications,
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`employment and research history, and professional activities and awards.
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`6.
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`I received a Bachelor of Science degree in Food Science and
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`Technology in 1987, a Master of Science degree in Food Science and Technology
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`in 1990, and a Ph.D. in 1996 in Food Science & Technology and Meat Science, all
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`from Iowa State University.
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`7.
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`I am presently an Associate Professor of Meat Science and Technology,
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`in the Department of Animal Science at Iowa State University, USA. At Iowa State,
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`I teach courses in “Foods of Animal Origin,” “Science and Technology of Value-
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`Added Meat Products,” and “Advanced Meat Processing,” and serve as Director of
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`the Online Graduate Certificate in Meat Science program.
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`8.
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`I joined the Iowa State faculty in 2015 after nineteen years in the meat
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`processing industry, during which I held key research & development posts in major
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`meat and food processing companies, primarily Kraft Foods/Oscar Mayer and John
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`Morrell Food Group (a division of Smithfield Foods).
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`9.
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`I have contributed numerous research articles, and several book
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`chapters and trade articles relating to food science and meat processing, including
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`oil structuring for animal fat replacement and fatty acid profile modification. See,
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`e.g., Kibler et al., Novel biphasic gels can mimic and replace animal fat in fully-
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`cooked coarse-ground sausage, 194 Meat Sci. 108984 (2022); Tarté et al., High-
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`oleic and conventional soybean oil oleogels structured with rice bran wax as
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`alternatives to pork fat in mechanically separated chicken-based bologna sausage,
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`131 LWT – Food Sci. & Tech. 109659 (2020); Wolfer et al., Replacement of pork
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`fat in frankfurter-type sausages by soybean oil oleogels structured with rice bran
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`wax, 145 Meat Sci. 352-362 (2018); see also Tarté, Leveraging meat flavor
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`understanding for product success, 5(3):7 Meat Musc Biol. 1–6 (2022); Ruther et
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`al., Effects of processing method and non-meat binding ingredients on batter
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`stability, yield and texture of frankfurters, 44 J. Food Process Preserv. 14626 (2020);
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`Lee, Tarté, et al., Synergistic effects of starch nanoparticles and chitin nanofibers
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`on the stability of oil-in-water Pickering emulsions, 363 Food Chem. 130301 (2021).
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`10. Among my honors, I have served as President of Phi Tau Sigma, The
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`Honor Society of Food Science and Technology, past Chair of the Institute of Food
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`Technologists (IFT) Muscle Foods Division and Board Member of the American
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`Meat Science Association. In recognition of my longtime work and contributions in
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`this industry, I have been awarded the Meat Processing Award from the American
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`Meat Science Association.
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`11.
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`I am a regular invited speaker at national and international conferences,
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`symposia, workshops and webinars, and have presented my work at national and
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`international meetings and conferences, such as the Reciprocal Meat Conference,
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`the American Meat Science Association, the American Oil Chemists’ Society
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`Annual Meeting of the International Congress of Meat Science and Technology, and
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`the Institute of Food Technologists Annual Meeting.
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`12. My primary areas of expertise and research are meat further processing,
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`meat product formulation, non-meat ingredient technology and food safety
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`microbiology. During the course of my work at Kraft Foods and Oscar Mayer, I
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`worked on a variety of meat products in support of the Oscar Mayer, Louis Rich,
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`and Lunchables brands. I also led a team of researchers in developing new food
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`technologies to enable the development of new products, improve utilization of raw
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`materials, and cost, formula, and process improvements.
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`13.
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`In the course of my work at Kraft Foods, I also worked on the
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`development and improvement of meat substitute products. As an example of my
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`work on meat substitutes: in 2000, Kraft purchased Boca Burger, Inc., a
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`manufacturer and marketer of soy-based meat alternative products. I personally
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`worked on the development and improvement of the texture, appearance, flavor, and
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`meat-like characteristics of various Boca brand products. These products included
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`beef burger and chicken analog products (patties and nuggets).
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`III. SCOPE OF ASSIGNMENT
`14.
`In forming my opinions regarding the validity of the ’096 patent, I have
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`considered the ’096 patent’s specification, including the Abstract and the figures. I
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`have also considered the language of the patent’s claims, as those terms would have
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`been understood by a person having ordinary skill in the relevant field at least at the
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`time of the ’096 patent’s earliest possible priority date. I have also reviewed the
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`prosecution (the “file history”) of the ’096 patent.
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`15.
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`In forming my opinions, I have also considered the Exhibits that are
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`listed in the Petition and any additional materials and information cited in this
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`Declaration. I have also searched for and reviewed technical literature relevant to
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`the field of the ’096 patent.
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`I have also relied on my personal knowledge, education, training, and
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`16.
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`professional experience in order to form my opinions concerning the ’096 patent,
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`including my experience in researching, studying, developing, or using meat
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`substitutes and meat replica technology.
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`17. This Declaration explains, based on facts and information currently
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`available to me, the subject matter and opinions related to this Proceeding. As such,
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`I am prepared to provide expert testimony regarding opinions formed resulting from
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`my analysis of the issues and materials considered in this Declaration, if asked to do
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`so by the Board or by the parties’ attorneys.
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`18. Additionally, I may discuss my own work, teachings, and knowledge
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`of the state of the art in the relevant time period. I may rely on handbooks, textbooks,
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`technical literature, and the like to demonstrate the state of the art in the relevant
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`time period and the evolution of relevant technologies.
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`19. Furthermore, I reserve the right to consider and respond to any
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`arguments or technical literature that Patent Owner or its counsel may identify or
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`assert in this Proceeding. I reserve the right to amend or supplement the opinions
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`set forth in this Declaration as additional information becomes available to me and/or
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`in response to positions asserted by Patent Owner.
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`20. Throughout this Declaration, I refer to specific pages of the ’096 patent
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`and other documents. These citations are intended to be exemplary and are not
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`intended to convey that the citations are the only source of evidence to support the
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`propositions for which they are cited.
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`21.
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`I am being compensated for my time preparing this declaration for this
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`matter at a rate of $300 per hour. My compensation is in no way contingent upon
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`the outcome of this matter or on the opinions I offer. All of the opinions expressed
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`in this Declaration are my own.
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`IV. LEGAL UNDERSTANDING
`22.
`In this section I describe my understanding of certain legal principles
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`that I have relied upon in forming my opinions set forth in this Declaration.
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`23.
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`I have been informed of these legal standards by counsel for Motif. I
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`am not an attorney and I have not researched the law on patent invalidity. I am
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`relying only on Motif’s attorneys relating to these legal standards.
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`24.
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`Person of Ordinary Skill in the Art
`I am informed that patent validity is determined from the perspective
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`of a person of ordinary skill in the pertinent art at the time of the invention
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`(“POSITA”). I understand that a POSITA is a hypothetical person who is presumed
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`to be aware of all pertinent art, conventional wisdom in the art, and is a person of
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`ordinary creativity—not an automaton.
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`25.
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`In deciding the level of ordinary skill in the art, I am informed that the
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`following factors may be considered:
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`7
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`Case No.: IPR2023-00206
`U.S. Patent No. 9,943,096
` the levels of education and experience of persons working in the field;
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` the types of problems encountered in the field;
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` the sophistication of the technology.
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` Claim Construction
`26.
`I am informed that a patent may include two types of claims,
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`independent claims and dependent claims. An independent claim stands alone and
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`includes only the limitations it recites. A dependent claim can depend from an
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`independent claim or another dependent claim. I am informed that a dependent
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`claim includes all the limitations that it recites, in addition to the limitations recited
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`in the claim from which it depends.
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`27.
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`I understand that patent claim terms can be interpreted, or “construed.”
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`I understand that, in construing a claim, the words of a pate