`
`Blake Robert Peterson
`
`Blake R. Peterson
`
`Business Address_The Ohio State University, College of Pharmacy
`Division of Medicinal Chemistry and Pharmacognosy
`500 W. 12th Ave, Columbus, OH 43210
`Email: peterson.1119@osu.edu; Office: (614) 247-7729
`https://www.linkedin.com/in/blake-r-peterson-3428b616/
`https://scholar.google.com/citations?user=dhiOh60AAAAJ&hi=en
`
`Educational Background
`
`Damon Runyon - Walter Winchell Cancer Research Foundation Postdoctoral Fellow
`Harvard University (1995 — 1998)
`
`Ph.D. in Chemistry, University of California, Los Angeles (1994)
`
`B.S. in Chemistry (with distinction), University of Nevada, Reno (1990)
`
`Professional Experience
`
`The Ohio State University, Division of Medicinal Chemistry and Pharmacognosy
`Professor of Medicinal Chemistry with Tenure (2019 — Present)
`Chair of the Division of Medicinal Chemistry and Pharmacognosy (2019 — Present)
`Co-Leader, Translational Therapeutics, OSU Comprehensive Cancer Center (2019 — Present)
`Co-Director, Medicinal Chemistry Shared Resource, OSUCCC (2019-Present)
`
`The University of Kansas, Department of Medicinal Chemistry
`Regents Distinguished Professor of Medicinal Chemistry with Tenure (2008 — 2019)
`Adjunct Professor of Medicinal Chemistry (2019 — Present)
`Co-Leader, Synthetic Chemical Biology Core Facility (2012-2019)
`
`Indigo BiosciencesInc., State College, PA
`Co-Founder (2005); Memberof the Board of Directors (2005 — 2014)
`
`The Pennsylvania State University, Department of Chemistry
`Assistant (1998 — 2004) and Associate (2004 — 2007, with Tenure) Professor of Chemistry
`
`Harvard University, Department of Chemistry and Chemical Biology
`Damon Runyon-Walter Winchell Cancer Research Postdoctoral Fellow (1995 — 1998)
`
`Swiss Federal Institute of Technology (ETH - Ziirich), Department of Chemistry
`Research Assistant (1992 — 1994)
`
`University of California, Los Angeles, Department of Chemistry and Biochemistry
`Research Assistant (1991 — 1992); Teaching Assistant (1990 — 1991)
`
`Research Interests
`My research group creates chemical tools for the study of cancer biology and other biological
`systems. By conducting interdisciplinary research in the fields of bioorganic / medicinal chemistry and
`chemical biology, we investigate anticancer agents, molecular probes, methods for therapeutic targeting,
`and tools for target identification. Our expertise includes the synthesis of steroids, lipids, nucleosides,
`peptides, heterocycles, fluorophores, and protein conjugates, and the evaluation of these compounds in
`biochemical assays, whole cell assays, and model organisms. Our goal is to identify new therapeutic
`approaches and mechanisms. Representative published compounds are shownonpage2.
`
`MSN Exhibit 1003 - Page 1 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page | of43
`
`Curriculum vitae, 3/5/22
`
`
`
`Our
`@ me Pennsylvania
`Green
`O7OR
`
`Blake R. Peterson
`
`@ - Assay Drug Dev. Techy 201199, 136-146
`O-
`Chem. Commun®201598T, 14624-14627
`
`Org. Lett. 2006, 8, 581-584
`Synthesis 2014,46, 158-164
`
`J. Med. Chem. 2011, 54, 1126-1139
`ACS Chem.Biol. 2015, 10, 570-576
`
`Oregon Green
`vancomycin oe
`
`HO OH
`J. Med. Chem. 2010,
`53, 7958-7966
`
`HO. OH
`J. Med. Chem. 2006,
`49, 6166-6169
`
`J. Med. Chem. 2004,
`47, 4985-4988
`
`Synthetic
`vancomycin
`receptor
`
`4
`
`Asp-242
`
`J. Biol. Chem. 2008, 283, 7705-7712
`
`J. Am. Chem. Soc. 2003, 125, 3692-3693
`
`Ons)
`
`Posterior acidity
`
`Et.N
`
`OLA,
`
`:
`NEte
`
`C. elegans
`v AO
`NEEeam t=4s
`
`J. Am. Chem. Soc.
`2007, 129, 268-269
`
`J. Am. Chem. Soc.
`2014, 136, 5241-5244
`
`rN
`ACS Chem.Biol.
`2013, 8, 636-642 GNglalelatetereliny
`
`Fluorescent ER
`targeting motif
`a———_7
`N
`i A>
`Membrane-lytic
`
`Op On NAShyNe HNO
`F Lk oI F
`A c
`PC4 peptide
`CO Me Angew. Chem.Int. Ed.
`Gao
`‘te'N-SSAWWSYWPPVA
`2015, 54, 9696-9699
`
`Fluorophore
`
`te.
`Me Me Me
`
`Cytotoxic
`warhead
`
`2017, 36, 6927-6931 Org: Lett. 2007, 9, 3741-3744
`
`Loading of
`H) endosomes
`
`Disruption of
`endosomes
`
`Mammalian cells
`
`am. Chem. Soc. 2008, 130, 10064-10065
`
`grey
`acire
`
`eeu
`
`SR
`
`hodol
`fluoro-
`phore
`
`profluorophore
`Phagocytosed
`tentagel bead
`ACS Chem. Biol. 2018, 13, 2595-2602
`
`oO
`
`0yt N NOAAOG
`H
`
`QO
`
`N
`
`oO
`
`Angew. Chem.Int. Ed.
`
`Int. J. Biochem. Cell Biol. 2010, 42, 337-345
`
`CF3
`NS
`AS
`
`CFs
`
`MSN Exhibit 1003 - Page 2 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page 2 of 43
`
`Curriculum vitae, 3/5/22
`
`
`
`Honors and Awards
`
`Blake R. Peterson
`
`Namedthe John W. Wolfe Chair in Cancer Research by the OSUCCC (2020)
`Elected Fellow of The American Association for the Advancement of Science (AAAS, 2013)
`Fordistinguished contributions to the field ofbioorganic chemistry, particularly the development
`ofsynthetic mimics ofcell surface receptors andfluorescent probesofbiological systems
`Leading Light Research Award, University of Kansas (2012)
`Named an Eminent Scholar by the Kansas Biosciences Authority (2008)
`Nameda Regents Distinguished Professor by the Regents of the University of Kansas (2008)
`Elected Co-Chair of the 2007 Gordon Conference on Bioorganic Chemistry (Andover, NH)
`Elected to the Faculty of 1000 Biology (2004): Chemical Biology, Macromolecular Chemistry
`Camille Dreyfus Teacher Scholar Award (2004)
`Department of Defense Breast Cancer Research Concept Award (2004)
`Department of Defense Prostate Cancer Research Idea Award (2004)
`Invited Speaker at the Chemistry and Biology of Peptides Gordon Conference (Ventura, CA, 2004)
`Invited Speaker at the Gordon Conference on Bioorganic Chemistry (Andover, NH, 2003)
`Named an American Cancer Society Research Scholar (2003)
`Department of Defense Breast Cancer Research Concept Award (2003)
`Department of Defense Breast Cancer Research Concept Award (2001)
`Department of Defense Breast Cancer Research Concept Award (2000)
`Damon Runyon - Walter Winchell Cancer Research Postdoctoral Fellow (1995-1997)
`Phi Kappa Phi HonorSociety (1990)
`American Institute of Chemists Outstanding Senior Student Award (1990)
`National Science Foundation Research Experience for Undergraduates Award (1990)
`Golden Key National Honor Society (1989)
`American Institute of Chemists Outstanding Senior Student Award (1989)
`Dean’s List (1989)
`University of Nevada, Reno Undergraduate Teaching Fellowship (1989)
`University of California, Santa Cruz Summer Undergraduate Research Fellowship (1988)
`Charles F. Cutts Scholarship (1988)
`Mr. and Mrs. Murdock McCleod Scholarship (1988)
`Chemistry Faculty Scholarship (1987)
`Chemistry Alumni Scholarship (1987)
`R. C. Fuson Scholarship (1986)
`
`Current Professional Memberships
`
`Member, American Chemical Society (ACS)
`Memberand Elected Fellow, American Association for the Advancement of Science (AAAS)
`Member, The Ohio State University Comprehensive Cancer Center (OSUCCC)
`Member, American Association for Cancer Research (AACR)
`Member, Pelotonia Institute for Immuno-oncology (PHO)
`Member, Center for Cancer Engineering (CCE-CURES)
`
`Graduate Students, Postdoctoral Fellows, and Undergraduates
`
`Current Graduate Students, Postdoctoral Fellows, and other Co-Workers
`
`Dr. Erick Carlson — Postdoctoral Fellow (8/19 — Present)
`Ms. Lillian Cool — Graduate Student in Medicinal Chemistry and Pharmacognosy(8/20 — Present)
`Mr. Xiaojun Hu — Graduate Student in Medicinal Chemistry and Pharmacognosy (8/19 — Present)
`Mr. Szu (Sean) Lee— Graduate Student in Medicinal Chemistry and Pharmacognosy (8/21 — Present)
`Dr. Digamber Rane — Senior Researcher (5/15 — Present)
`Dr. Anver Shaik — Postdoctoral Fellow (3/21 — Present)
`Dr. Serena Zhao —Research Specialist (10/20 — Present)
`
`MSN Exhibit 1003 - Page 3 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page 3 of43
`
`Curriculum vitae, 3/5/22
`
`
`
`Former Graduate Students and Postdoctoral Fellows (1998-Present)
`
`Blake R. Peterson
`
`Dr. Angelo Andres — HHMIGilliam Graduate Student in Medicinal Chemistry (1/17 — 2/22, Senior
`Scientist, AstraZeneca Pharmaceuticals)
`Dr. Sonalee Athavankar — Graduate Student in Chemistry (11/99-1/06, Principal Scientist, Advinus
`Therapeutics)
`Kyle Bailey — Graduate Student in Medicinal Chemistry (1/08-8/11, Research Assistant, The
`University of Pittsburgh)
`Dr. Aaron Bender — Research Associate & Director of Molecular Probes Core (11/09-3/15,
`Instructor of Biological and Physical Sciences, Central Wyoming College)
`Zach Biddle — Graduate Student in Chemistry (10/04-8/06, Senior Managerat Ernst & Young)
`Dr. Siwarutt Boonyarattanakalin — Graduate Student
`in Chemistry (11/00-12/05, Associate
`Professor at SIT,
`Thailand)
`Sutang Cai — Graduate Student in Chemistry (10/05-12/09, Scientist, Exide Tech., Atlanta, GA)
`Dr. Daniel D. Clark — Graduate Student in Chemistry (11/98-10/04, Associate Professor of
`Chemistry, Mathematics, and Physics at Clarion University, PA)
`Dr. Steffen P. Creaser — Postdoctoral Fellow (2/00—-10/02, Regulatory Affairs International
`Associate II, Genzyme, Cambridge, MA)
`Dr. Mike DeGrazia — Graduate Student in Chemistry (11/01-10/07, Patent Attorney at McCarter &
`English, LLP)
`Dr. Jocelyn Edathil — MD/PhD Graduate Student in Chemistry (8/03-8/08, Assistant Professor,
`Temple University)
`Robert Feltz — Graduate Student in Chemistry (6/04-6/06, Supervisor of Analytical R&D, Lannett
`Co.)
`Dr. Safiyyah Forbes — TRACDA Postdoctoral Fellow (8/11-7/13, Assistant Professor, Skyline
`College, CA)
`Dr. Ligiang Fu — Postdoctoral Fellow (7/10-6/13, Senior Scientist, Johnson and Johnson, China)
`Dr. Zhe (Gavin) Gao — Graduate Student in Medicinal Chemistry (10/12 — 6/19, Postdoctoral fellow
`at Texas A&M)
`Dr. Joseph Gargano — Postdoctoral Fellow (10/03—5/04, Technical Director at Vedeqsa Inc.)
`Dr. Daniel A. Harki— Graduate Student in Chemistry (11/99-6/05, Associate Professor ofMedicinal
`Chemistry, U. Minnesota)
`Dr. Enfei He — Postdoctoral Fellow (12/98-8/99, Global Strategic Purchasing Manager, Albemarle
`Corp.; Houston TX)
`Dr. Bart Heldreth — Postdoctoral Fellow (1/05 — 10/06, Chemist at Cosmetic Ingredient Review,
`Washington DC)
`Dr. Rebecca Henkhaus— Postdoctoral Fellow (5/08-8/09, Technical Supervisor, Clinical Reference
`Laboratory, Kansas City, KS)
`Dr. Abu Hossion — IRACDAPostdoctoral Fellow (2/14 — 8/16, Instructor in Chemistry, Cloud
`County Community College)
`Dr. Stephen L. Hussey — Graduate Student in Chemistry (1 1/98-4/03, Director at Anton Paar)
`Dr. David Hymel — Graduate Student in Medicinal Chemistry (1/09-10/14, subsequently a Postdoc
`at NCI with Terry Burke; currently a Research Scientist at Novo Nordisk, Seattle)
`Prof. Guafeng (Gordon) Jia — Visiting Associate Professor (5/15 — 9/15)
`Ms. Kelsey Knewtson — Graduate Student in Medicinal Chemistry (1/13 — 5/19, currently a
`postdoctoral fellow with Jenny Robinson at the University of Kansas)
`Ms. Molly M. Lee — Graduate Student
`in Medicinal Chemistry (1/12 — 12/16, subsequent
`postdoctoral fellow with Don Bottaro at NCI, currently a Chemist at CDER, FDA)
`Dr. Bailin Lei — Postdoctoral Fellow (7/17 — 5/19)
`Dr. Ze Li— Postdoctoral Fellow (5/09-7/10, Research Scientist at Covance, Indianapolis, IN)
`Dr. Megan M. MacBride — Graduate Student in Chemistry (11/99-12/05, Senior Scientist at
`Taconic)
`Dr. Scott E. Martin — Graduate Student in Chemistry (11/98-5/04, Group Leader at Genentech)
`Mr. Matt Meinig — Graduate Student in Medicinal Chemistry (10/09 — 9/15, Pharmacologist, US
`Army Medical Research Institute of Infectious Diseases)
`Dr. Laurie F. Mottram — Graduate Student in Chemistry (11/02-9/07, Senior Project Managerat
`Johnson Matthey)
`
`MSNExhibit 1003 - Page 4 of 43
`MSNv.Bausch - IPR2023-00016
`
`Page 4 of43
`
`PVE,A
`
`
`
`in Chemistry (11/98-5/01, Scientist at Novartis
`
`Blake R. Peterson
`Dr. Smita M. Muddana — Graduate Student in Chemistry (1 1/98-3/04, Research Scientist at Clorox)
`Cameron Ng — Graduate Student in Medicinal Chemistry (10/11-1/14, Senior Research Associate,
`Heron Therapeutics)
`Dr. Chamani Perera — Research Associate (1/10 — 3/15, Director of the Synthetic Chemical Biology
`Core Facility, the University of Kansas (3/15-Present)
`Ms. Sahishna Phaniraj — Graduate Student in Medicinal Chemistry (1/15 — 11/19, Regulatory
`Affairs Specialist III at Sanofi Pasteur)
`Aimee M. Price — Graduate Student
`Pharmaceuticals)
`Dr. Sheryl A. Rummel — Graduate Student in Chemistry (6/03-8/08, Director of Undergraduate
`Instrumentation at Penn State University)
`Dr. Kalai Selvi Shanmugam — Postdoctoral Fellow (3/09-8/10)
`Dr. Krishna Sharma — Postdoctoral Fellow (9/19 — 11/21, Researcher at Iowa State U.)
`Dr. Sangarappan Sivakumar — Postdoctoral Fellow (10/02—10/03, Director at Vector Bio)
`Dr. Qi Sun — Graduate Student (1/04-5/09, Professor, School of Chemistry and Chemical
`Engineering, Jiangxi Science and Technology Normal University, Nanchang, China)
`Mr. Tomas Smith — Graduate Student in Medicinal Chemistry (1/18 — 7/19, Research ScientistII at
`Novartis Institutes for Biomedical Research)
`Kathleen M. Veety — Graduate Student in IBIOS Chemical Biology (6/01-5/03, High school
`teacher in Baltimore, MD)
`Dr. Nicole Windmon — IRACDA Postdoctoral Fellow (8/15 — 6/16, Upper School Chemistry
`Professor, The Webb Schools, Claremont, CA)
`Dr. Robert Winefield — Postdoctoral Fellow (9/10-1/12, Field Service Engineer, ThermoFisher)
`Dr. Zachary Woydziak — IRACDAPostdoctoral Fellow (9/09-8/12, Associate Professor at Nevada
`State College)
`Dr. Runzhi Wu — Graduate Student in Chemistry (Penn State, 10/05-8/10, Technology Specialist in
`China)
`Dr. Jun Xu — Postdoctoral Fellow (7/10-12/11, Research Scientist at ABA Chemical)
`Ning Yang — Graduate Student in Medicinal Chemistry (1/11-9/13)
`Ms. Yuwen (Alicia) Yin — Graduate Student in Medicinal Chemistry (1/16 — 3/21, Postdoctoral
`Fellow with Jianzhu Chen at MIT)
`
`Thesesand Dissertations Supervised
`2017-2022 Ph.D. Dissertation, Medicinal Chemistry (KU) “New Approachesfor Quantification of
`Engagement and Modulation of Targets by Small Molecules in Living Cells” Angelo E. Andres
`
`2016-2021 Ph.D. Dissertation, Medicinal Chemistry (KU) “Novel Small Molecule Probes and
`Methods to Quantify Binding to C1 Domains of Protein Kinase C in Living Cells” Yuwen Yin
`
`2014-2019 Ph.D. Dissertation, Medicinal Chemistry (KU) “Studies of Interactions of Small
`Molecules with Membranesand Proteins” Sahishna M. Phaniraj
`
`2017-2019 Master’s Thesis, Medicinal Chemistry (KU) “Discovery of Novel Inhibitors of Cellular
`Efflux by High-Content Screening with a Fluorescent Mimic of Taxol” Tomas Smith
`
`2012-2019 Ph.D. Dissertation, Medicinal Chemistry (KU) “Synthesis and Evaluation of
`Fluorescent Tools for Studies of Cancer Biology” Zhe Gao
`
`2012-2019 Ph.D. Dissertation, Medicinal Chemistry (KU) “Studies of Novel Targeted Drug
`Delivery Systems and Molecular Probes of Cancer Biology” Kelsey E. Knewtson
`
`2012-2016 Ph.D. Dissertation, Medicinal Chemistry (KU) “An Improved Synthesis of the Pacific
`Blue Fluorophore and Fluorescence-Based Studies of Receptor-Ligand Interactions” Molly M. Lee
`
`MSN Exhibit 1003 - Page 5 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page 5 of43
`
`Curriculum vitae, 3/5/22
`
`
`
`Blake R. Peterson
`2009-2015 Ph.D. Dissertation, Medicinal Chemistry (KU) “Synthesis and Phenotypic Discovery
`of Molecular Probes of Biological Systems” James (Matt) Meinig
`
`2008-2014 Ph.D. Dissertation, Medicinal Chemistry (KU) “Synthetic Molecular Probes of
`Endocytosis, Escape from Endosomes,and Protein-Protein Interactions” David Hymel
`
`2011-2013 Master’s Thesis, Medicinal Chemistry (KU) — "Synthetic Delivery Systemsthat
`Control Release of Anticancer Agents from Early Endosomes" Ning Yang
`
`2008-2011 Master’s Thesis, Medicinal Chemistry (KU) — "Improving the Yeast Three Hybrid
`System for High-Throughput Target Discovery" Kyle Bailey
`
`2005-2010 Ph.D. Dissertation, Chemistry (Penn State) “Synthesis of Novel Antiviral Agents and
`Fluorescent Molecular Probes” Runzhi Wu
`
`2004-2008 Ph.D. Dissertation, Integrative Biosciences (Penn State) “Advances in Synthesis and
`Applications of Artificial Cell Surface Receptors and Methodology for Preparation of Novel
`Antiviral Agents” Qi Sun
`
`2005-2009 Master’s Thesis, Chemistry (Penn State) — “Novel Artificial Cell Surface Receptors and
`Related Molecular Probes” Sutang Cai
`
`2003-2008 Ph.D. Dissertation, Chemistry (Penn State) — “Design, Synthesis, and Evaluation of
`Synthetic Mimics of Cell Surface Receptors” Sheryl A. Rummel
`
`2003-2008 Ph.D. Dissertation, Chemistry (Penn State) — “Design, Synthesis, Antiviral Evaluation
`and Metabolism of Nucleoside Analogs” Jocelyn Edathil
`
`2001-2007 Ph.D. Dissertation, Chemistry (Penn State) — “Design, Synthesis, and Evaluation of
`Fluorescent Small Molecule Probes of Biological Systems” Michael J. DeGrazia
`
`2002-2007 Ph.D. Dissertation, Chemistry (Penn State) — “Design, Synthesis and Biological
`Evaluation of Cell-Permeable Fluorescent Molecular Probes” Laurie F. Mottram
`
`2005-2007 Undergraduate Honors Thesis (Penn State) — “Chlorinated Fluorophores” Rebecca E.
`Kovel
`
`2004-2006 Master’s Thesis, Chemistry (Penn State) — “Synthetic Cell Surface Receptors Designed
`for Internalization of Macromolecules” Zach Biddle
`
`2004-2006 Master’s Thesis, Chemistry (Penn State) — “Synthetic Ribonucleosides as Antiviral
`Agents and Improved Nucleoside Glycosylation Methodology” Robert Feliz
`
`1999-2005 Ph.D. Dissertation, Chemistry (Penn State) — “Modulating Protein Function Through
`Small Molecule-Mediated Covalent and Non-Covalent Modifications” Sonalee Athavankar
`
`2000-2005 Ph.D. Dissertation, Chemistry (Penn State) — “Synthetic Mimics of Mammalian Cell
`Surface Receptors” Siwarutt Boonyarattanakalin
`
`1999-2005 Ph.D. Dissertation, Chemistry (Penn State) — “Nuclear Receptors as Drug Targets:
`Design and Biological Evaluation of Small Molecule Modulators of Nuclear Receptor Action”
`Megan M. MacBride
`
`1999-2005 Ph.D. Dissertation, Chemistry (Penn State) — “Chemical Synthesis of Base-Modified
`Ribonucleosides as Novel Antiviral Agents” Daniel A. Harki
`
`MSN Exhibit 1003 - Page 6 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page 6 of 43
`
`Curriculum vitae, 3/5/22
`
`
`
`Blake R. Peterson
`1998-2004 Ph.D. Dissertation, Chemistry (Penn State) — “Synthesis and Evaluation of Synthetic
`Cell Surface Receptors and Related Biological Probes” Scott E. Martin
`
`1998-2004 Ph.D. Dissertation, Chemistry (Penn State) — “Evaluation and Identification of
`Oncogenic Protein Tyrosine Kinases with Yeast Genetic Systems” Daniel D. Clark
`
`2003-2004 Undergraduate Honors Thesis, Chemistry (Penn State)
`Metabolically Stable Estrogen Receptor Ligands" Ruth Bringman
`
`- "Estrone Oximes as
`
`2003-2004 Undergraduate Honors Thesis, Biochemistry and Molecular Biology (Penn State) -
`"Fluorescent Cellular Sensors of Antiestrogens" Jonathan Belman
`
`1998-2004 Ph.D. Dissertation, Chemistry (Penn State) — “Synthesis and Evaluation of Nuclear
`Hormone Receptor Ligands” Smita S. Muddana
`
`2001-2003 Master’s Thesis, IBIOS Chemical Biology (Penn State) — “Synthesis and Biological
`Evaluation of PeroxisomeProliferator-Activated Receptor Ligands” Kathleen M. Veety
`
`1998-2003 Ph.D. Dissertation, Chemistry (Penn State) — “Synthesis and Analysis of Artificial
`Cellular Receptors and Molecular Probes” Stephen L. Hussey
`
`1998-2001 Master’s Thesis, Chemistry (Penn State) — “Synthesis and Biological Evaluation of
`Novel 118-Substituted Steroidal Androgen Receptor Ligands” Aimee M.Price
`
`1998-2000 Undergraduate Honors Thesis, Premedicine (Penn State) - "Inhibition of Estrogen
`Receptor-Mediated Transcription Through Farnesylation and Palmitoylation" Joshua A. Englert
`
`Invited Seminars
`123. University of California Riverside, Department of Chemistry (5//9/2/) “Subcellular Targeting for
`Phenotypic Drug Discovery”
`
`122. Michigan Technological University, Department of Chemistry (4/9/21) “Subcellular Targeting for
`Phenotypic Drug Discovery”
`
`121. Ohio State University, Pharmacology Seminar Series (10/29/19) “Subcellular Targeting for Phenotypic
`Drug Discovery”
`
`120. Ohio State University, Dean’s Corporate Council (10/25/19) “New Strategies for Early-Stage Drug
`Discovery at Ohio State”
`
`119. Ohio State University, Comprehensive Cancer Center, Grand Rounds (9/6/19) “New Strategies for
`Early-Stage Drug Discovery at Ohio State”
`
`118. Gordon Research Conference on Bioorganic Chemistry — Andover, NH (6/13/19) “Fluorescent Tools
`for Studies of Biological Systems”. Invited to present a seminar in place of Rami Hannoush.
`
`117. ETH-Ziirich, Dept. of Organic Chemistry (6/4/19) “Chemical Tools for Studies of Biological
`Systems”. Frang¢ois Diederich International Farewell Symposium.
`
`116. Ohio State University, Dept. ofMedicinal Chemistry and Pharmacognosy (12/18/18) “Chemical Tools
`for Studies of Cancer Biology”
`
`115. University of Kansas Medical Center, Dept. of Biochemistry and Molecular Biology (11/2/18)
`“Chemical Tools for Studies of Biological Systems”
`
`MSNExhibit 1003 - Page 7 of 43
`MSNv.Bausch - IPR2023-00016
`
`Page 7 of43
`
`PIG, SNe
`
`
`
`Blake R. Peterson
`114. Kansas State University, Dept. ofBiochemistry and Molecular Biophysics (9/12/18) “Chemical Tools
`for Studies of Cancer Biology”
`
`113
`
`. University ofNew Mexico, Cancer Center (4/2/18) “Chemical Tools for Studies of Cancer Biology”
`
`112
`
`. Purdue University, Department ofMedicinal Chemistry and Molecular Pharmacology (2/21/18)
`“NewStrategies for Controlling Signaling and Trafficking Pathways”
`
`111
`
`. Purdue University, Department ofMedicinal Chemistry and Molecular Pharmacology (2/20/18)
`“Chemical Tools for Studies of Biological Systems”
`
`110
`
`. University ofMinnesota, Department ofMedicinal Chemistry (2/6/18) “Chemical Tools for Studies of
`Biological Systems”
`
`109.
`
`University ofNebraska, Lincoln, Department of Chemistry (1/19/18) “Chemical Tools for Studies of
`Biological Systems”
`
`108.
`
`University of Arizona, Tucson, Department of Pharmacology and Toxicology (9/26/17) “Academic
`Drug Discovery: A Chemical Biology Perspective”
`
`107.
`
`University of Arizona, Tucson, Department of Pharmacology and Toxicology (9/25/17) “Chemical
`Tools for Studies of Biological Systems”
`
`106.
`
`University of Nevada, Reno, Department of Chemistry (3/17/17) “Discovery of New Therapeutic
`Strategies Using Synthetic Molecular Probes”
`
`105.
`
`Wichita State University, Department of Biology (10/24/16) “Discovery of New Therapeutic
`Strategies Using Synthetic Molecular Probes”
`
`104.
`
`Nevada State College, Research Day Keynote Speaker (4/15/16) “Discovery of New Therapeutic
`Strategies Using Synthetic Molecular Probes”
`
`103.
`
`Washburn University, Chemistry Club (2/12/16) “Discovery of New Therapeutic Strategies Using
`Synthetic Molecular Probes”
`
`102.
`
`University of Kansas, Dept. of Medicinal Chemistry (10/8/15) “Discovery of New Therapeutic
`Strategies Using Synthetic Molecular Probes”
`
`101.
`
`University ofMissouri, Kansas City, School ofPharmacy (10/6/15) “Discovery of New Therapeutic
`Strategies Using Synthetic Molecular Probes”
`
`100.
`
`KansasArea Life Sciences Institute (KCALSI, 4/6/15) “How Synthetic Molecular Probes can be Used
`to Discover New Therapeutic Strategies”
`
`99.
`
`98.
`
`OF.
`
`96.
`
`University of Kansas, Dept of Pharmaceutical Chemistry (12/2/14) “Synthetic Lethal Targeting of
`Cell Surface Receptors”
`
`University ofKansas Cancer Center (6/17/14) “Synthetic Lethal Delivery Systems for Targeting of
`Cancer”
`
`University of Kansas Medical Center, Dept. of Molecular and Integrative Physiology (10/21/13)
`“Synthetic Cell Surface Receptors and Fluorescent Molecular Probes”
`
`University ofKansas Cancer Biology Group (7/1 1/13) “How Studies of Fluorescent Molecular Probes
`Led to a New Strategy for Targeting Cancer Cells”
`
`MSN Exhibit 1003 - Page 8 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page 8 of43
`
`Curriculum vitae, 3/5/22
`
`
`
`95.
`
`94.
`
`93.
`
`92.
`
`91.
`
`90.
`
`89.
`
`88.
`
`87.
`
`86.
`
`85.
`
`84.
`
`83.
`
`82.
`
`81.
`
`80.
`
`79.
`
`78.
`
`77.
`
`Blake R. Peterson
`Kansas State University, Dept. ofChemistry (2/28/13) “Synthetic Mimics of Mammalian Cell Surface
`Receptors and Related Molecular Probes”
`
`Tecom Inc., Nanchang, China (10/13/11) "Crafting Fluorescent Small Molecules to Probe Biological
`Systems"
`
`Jiangxi Science and Technology Normal University, Nanchang, China (10/12/11) “Crafting
`Fluorescent Small Molecules to Probe Biological Systems"
`
`Tsinghua University, Beijing, China (10/11/11) "Crafting Fluorescent Small Molecules to Probe
`Biological Systems"
`
`New Mexico State University, Dept. of Chemistry (2/24/11) “Synthesis of Fluorescent Probes of
`Biological Systems”
`
`KU Higuchi Biosciences Center Science Talks, (12/3/10) “Crafting Fluorescent Small Molecules to
`Probe Biological Systems”
`
`Merck Pharmaceuticals, Dept. of Medicinal Chemistry (6/2/10) “Synthetic Mimics of Mammalian
`Cell Surface Receptors”
`
`University ofArkansas, Dept. of Chemistry (3/1/10) “Synthetic Mimics of Mammalian Cell Surface
`Receptors”
`
`University ofArizona, Dept. of Chemistry (2/25/10) “Synthetic Mimics of Mammalian Cell Surface
`Receptors”
`
`University ofKansas Analytical Chemistry Seminar (12/7/09) “A New Strategy for Drug Delivery:
`Synthetic Molecules that Catch and Release a Specific Membrane Trafficking Pathway”
`
`University ofKansas Combinatorial Methodology and Library Development Center, Keynote Address
`(10/26/09) “Synthetic Mimics of Mammalian Cell Surface Receptors”
`
`University of Iowa, Division of Medicinal and Natural Products Chemistry (10/5/09) “Synthetic
`Mimics of Mammalian Cell Surface Receptors”
`
`St. Jude, Dept. of Chemical Biology and Therapeutics (9/30/09) “A New Strategy for Drug Delivery:
`Synthetic Molecules that Catch and Release a Specific Membrane Trafficking Pathway”
`
`University ofNevada, Reno, Lightner Conference (8/15/09) “Synthetic Mimics of Mammalian Cell
`Surface Receptors”
`
`University of Kansas Medical Center, Sullivan Conference (6/12/09) “A New Strategy for Drug
`Delivery: Synthetic Molecules that Catch and Release a Specific Membrane Trafficking Pathway”
`
`Calvert Research, Cary NC (6/9/09) “A New Strategy for Drug Delivery: Synthetic Molecules that
`Catch and Release a Specific MembraneTrafficking Pathway”
`
`University of Kansas, Inaugural Distinguished Professor Lecture (4/23/09) “Molecular Tools that
`Integrate Chemistry with Biology”
`
`University of Kansas, Cancer Center Round Table (2/18/09) “A New Strategy for Drug Delivery:
`Synthetic Molecules that Catch and Release a Specific Membrane Trafficking Pathway”
`
`University ofKansas, Dept. ofMolecular Biosciences (2/9/09) “Synthetic Mimics of Mammalian Cell
`Surface Receptors”
`
`MSN Exhibit 1003 - Page 9 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page 9 of 43
`
`Curriculum vitae, 3/5/22
`
`
`
`70.
`
`Blake R. Peterson
`Wichita State University, Department ofChemistry (11/19/08) “Synthetic Mimics of Mammalian Cell
`Surface Receptors”
`
`75.
`
`Alnylam Pharmaceuticals (11/13/08) “Synthetic Mimics of Mammalian Cell Surface Receptors”
`
`74.
`
`73.
`
`72.
`
`71.
`
`70.
`
`69.
`
`68.
`
`67.
`
`66.
`
`65.
`
`64.
`
`63.
`
`62.
`
`61.
`
`60.
`
`59.
`
`58.
`
`Rotary Club, Lawrence KS (11/10/08) “University Research: A Key Link for Commercialization of
`Bioscience Discoveries”
`
`Boston College, Department of Chemistry (4/22/08) “Synthetic Mimics of Mammalian Cell Surface
`Receptors”
`
`Tufts University, Department of Chemistry (2/5/08) “Synthetic Mimics of Mammalian Cell Surface
`Receptors”
`
`University of Kansas, Department of Pharmaceutical Chemistry (10/11/07) “Synthetic Mimics of
`Mammalian Cell Surface Receptors: New Tools for Drug Delivery and Probes of Cellular Biology”
`
`Novartis Institutesfor Biomedical Research (10/2/07) “Synthetic Mimics of Mammalian Cell Surface
`Receptors: New Tools for Drug Delivery”
`
`Syracuse University, Department of Chemistry (5/1/07) “Synthetic Mimics of Mammalian Cell
`Surface Receptors”
`
`Mount Sinai School ofMedicine, Department of Structural and Chemical Biology — New York, NY,
`(4/26/07) “Synthetic Mimics of Mammalian Cell Surface Receptors”
`
`Virginia Tech, Department of Chemistry (4/6/07) “Synthetic Mimics of Mammalian Cell Surface
`Receptors”
`
`Penn State University Hershey Medical School, Dept. of Pharmacology— Hershey, PA (3/12/07)
`“Synthetic Mimics of Mammalian Cell Surface Receptors: A New Strategy for Drug Delivery”
`
`University ofKansas, Dept. ofMedicinal Chemistry, Lawrence, KS (1/12/07) “Synthetic Mimics of
`Mammalian Cell Surface Receptors”
`
`University of West Florida, Department of Chemistry (12/1/06) “Synthetic Mimics of Mammalian
`Cell Surface Receptors”
`
`New York Academy ofSciences, Chemical Biology Discussion Group (11/9/06) “Synthetic Mimics of
`Mammalian Cell Surface Receptors”
`
`University of California, Santa Barbara, Department of Chemistry (11/3/06) “Synthetic Mimics of
`Mammalian Cell Surface Receptors”
`
`Brown University, Department ofChemistry (10/6/06) “Synthetic Mimics of Mammalian Cell Surface
`Receptors”
`
`Penn State University, Hershey Medical School Dept. of Microbiology and Immunology (3/30/06)
`“Synthetic Mimics of Mammalian Cell Surface Receptors: Prosthetic Molecules that AugmentLiving
`Cells”
`
`San Diego State University, Department of Chemistry (3/10/06) “Synthetic Mimics of Mammalian
`Cell Surface Receptors”
`
`San Diego State University, DepartmentofBiology (3/9/06) “Chemical Biology of Nuclear Hormone
`Receptors ”
`
`MSNExhibit 1003 - Page 10 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page 10 of 43
`
`Curriculum vitae, 3/5/22
`
`
`
`57.
`
`56.
`
`55.
`
`54.
`
`53.
`
`52.
`
`Blake R. Peterson
`University of Karlsruhe, Germany, Department of Chemistry (2/7/06) “Synthetic Mimics of
`Mammalian Cell Surface Receptors”
`
`Swiss Federal TechnicalInstitute (ETH-Ziirich) Department ofChemistry (2/6/06) “Synthetic Mimics
`of Mammalian Cell Surface Receptors”
`
`University of California, Riverside Department of Chemistry (1/25/06) “Synthetic Mimics of
`Mammalian Cell Surface Receptors: Prosthetic Molecules that Augment Living Cells”
`
`University ofDelaware, Department of Chemistry (11/11/05) “Synthetic Mimics of Mammalian Cell
`Surface Receptors”
`
`Penn State University, Cancer Center (10/22/05) “New Approaches to Small Molecule Anticancer
`Agents”
`
`Penn State University, Crossover 2005 Symposium (10/14/05) “Synthetic Modulators of Estrogen and
`Androgen Receptors”
`
`51. Colorado State University, Department ofChemistry (10/3/05) “Synthetic Mimics of Mammalian Cell
`Surface Receptors: Prosthetic Molecules that AugmentLiving Cells”
`
`50. University ofMinnesota, NIH Training Grant Symposium — Chemical Biology: Unlocking Nature’s
`Secrets (6/1/05) “Synthetic Mimics of Mammalian Cell Surface Receptors: Novel Tools for Targeting
`Cells and Ligands”
`
`49. University of Pittsburgh, Dept. of Chemistry —Pittsburgh, PA (3/31/05) “Synthetic Mimics of
`Mammalian Cell Surface Receptors: Novel Tools for Targeting Cells and Ligands”
`
`48. Penn State University Hershey Medical School, Dept. of Pharmacology— Hershey, PA (11/22/04)
`“Synthetic Mimics of Mammalian Cell Surface Receptors: Novel Tools for Targeting Cells and
`Ligands”
`
`47. Northeast Regional Discussion Group Annual Meeting ofthe American Association of
`Pharmaceutical Scientists — Rocky Hill, CT (4/26/04) “Synthetic Mimics of Mammalian Cell
`Surface Receptors: Novel Tools for Targeting Cells and Ligands”
`
`46. Wyeth Research, Dept. of Chemical and Screening Sciences — Cambridge, MA (4/21/04) “Synthetic
`Mimics of Mammalian Cell Surface Receptors: Novel Tools for Targeting Cells and Ligands”
`
`45. Purdue University, Dept. of Medicinal Chemistry & Molecular Pharmacology — West Lafayette, IN
`(4/8/04) “Synthetic Mimics of Mammalian Cell Surface Receptors and Related Synthetic Cellular
`Probes”
`
`44. University of North Carolina, Dept. of Chemistry — Chapel Hill, NC (3/26/04) “Synthetic Mimics of
`Mammalian Cell Surface Receptors and Related Molecular Probes”
`
`43.
`
`The Pennsylvania State University Hershey Medical School, Division of Endocrinology — Hershey,
`PA (3/4/04) “Synthetic Mimics and Probes of Cellular Receptors”
`
`42. Gordon Research Conference on Chemistry and Biology of Peptides — Ventura, CA (2/17/04)
`“Synthetic Mimics of Mammalian Cell Surface Receptors”
`
`41.
`
`The Pennsylvania State University, Dept. of Chemistry — University Park, PA (11/6/03) “Nonnatural
`Cellular Receptors and Related Synthetic Cellular Probes”
`
`40. University ofIllinois, Dept. of Chemistry — Urbana/Champaign, IL (10/30/03) “Nonnatural Cellular
`Receptors and Related Synthetic Cellular Probes”
`
`MSN Exhibit 1003 - Page 11 of 43
`MSNv. Bausch - IPR2023-00016
`
`Page 11 of 43
`
`Curriculum vitae, 3/5/22
`
`
`
`Blake R. Peterson
`
`39.
`
`38.
`
`37.
`
`36.
`
`35.
`
`34.
`
`33.
`
`32.
`
`31.
`
`30.
`
`29.
`
`28.
`
`27.
`
`26.
`
`25.
`
`24.
`
`23.
`
`22.
`
`Michigan State University, Dept. of Chemistry — East Lansing, MI (10/1/03) “Nonnatural Cellular
`Receptors and Related Synthetic Cellular Probes”
`
`Gordon Research Conference on Bioorganic Chemistry — Andover, NH (6/15/03) “Construction of
`Nonnatural Cellular Receptors from Synthetic Molecules”
`
`University ofMinnesota Dept. ofMedicinal Chemistry — Minneapolis, MN (4/1/03) “Construction of
`Nonnatural Cellular Receptors and Cellular Probes from Synthetic Small Molecules”
`
`State University of New York, Stony Brook Dept. of Chemistry — Stony Brook, NY (2/6/03)
`“Construction ofNonnatural Cellular Receptors and Cellular Probes from Synthetic Small Molecules”
`
`University of Chicago Dept. of Chemistry — Chicago, IL (11/21/02) “Construction of Non