US 7,761,127 B2
`(10) Patent No.:
`a2) United States Patent
`AI-Aliet al.
`(45) Date of Patent:
`Jul. 20, 2010
`
`
`US007761127B2
`
`(54) MULTIPLE WAVELENGTH SENSOR
`SUBSTRATE
`
`(75)
`
`Inventors: Ammar AI-Ali, Tustin, CA (US);
`MohamedDiab, Mission Viejo, CA
`(US); Marcelo Lamego, Rancho Santa
`Margarita, CA (US); JamesP. Coffin,
`Mission Viejo, CA (US); Yassir
`Abdul-Hafiz, Irvine, CA (US)
`(73) Assignee: Masimo Laboratories, Inc., Irvine, CA
`(US)
`
`(*) Notice:
`
`Subject to any disclaimer, the term ofthis
`patent is extended or adjusted under 35
`U.S.C. 154(b) by 1154 days.
`
`(21) Appl. No.: 11/366,209
`:
`1,
`Filed:
`Mar. 1. 2006
`
`(22)
`
`(65)
`
`Prior Publication Data
`US 2006/0211922 Al
`Sep. 21, 2006
`Related U.S. Application Data
`(60) Provisional application No. 60/657,596,filed on Mar.
`1, 2005, provisional application No. 60/657,281, filed
`on Mar. 1, 2005, provisional application No. 60/657,
`268, filed on Mar. 1, 2005, provisional application No.
`60/657,759, filed on Mar. 1, 2005.
`Int. Cl.
`(51)
`(2006.01)
`AGIB 5/145
`(52) U.S.C.
`(58) Field of ClassificationSsearcha
`
`600/310: 362/84
`600/310
`600/331, 333, 336
`See application file for complete search history.
`References Cited
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`Primary Examiner—Eric F Winakur
`Assistant Examiner—Etsub D Berhanu
`(74) Attorney, Agent, or Firm—Knobbe Martens Olson &
`Bear LLP
`
`(57)
`
`ABSTRACT
`
`A physiological sensor has emitters configured to transmit
`optical radiation having multiple wavelengths in response to
`corresponding drive currents. A thermal mass is disposed
`proximatethe emitters so as to stabilize a bulktemperature for
`the emitters. A temperature sensor is thermally coupled to the
`thermal mass. The temperature sensor provides a temperature
`sensor output responsive to the bulk temperature so that the
`wavelengths are determinable as a function of the drive cur-
`rents and the bulk temperature.
`
`3,998,550 A
`
`12/1976 Konishi et al.
`
`30 Claims, 48 Drawing Sheets
`
`yo
`
`\
`
`teaeete122°
`THERMAL MASS
`
`
`
`
`‘201 710
`tw
`4 Be oJ, |EMITTERS
`
`4230
`
`"202
`(T=T)} SENSOR
`
`THERMAL
`ENERGY
`
`|
`
`SUBSTRATE
`
`1
`
`APPLE 1001
`
`APPLE 1001
`
`1
`
`

`

`
`
`PPPrrMNESNNSSPSPEPPPANSSSPEPEEPEPEEEEPPSPEEEPEMPPSPSeereeeeeeeeeeeeeePE
`
`4,694,833
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`5,392,777
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`5,429,128
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`D361,840
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`5,452,717
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`5,490,523
`5,494,032
`5,494,043
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`5,833,618PPPPPPrrrEEErrrrereeeeEeeEESSPEPASSESPEPEEEEeerPeeEeeeeeeeeeeeemeeeeeee
`
`US 7,761,127 B2
`
`Page 2
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`2
`
`

`

`US 7,761,127 B2
`
`Page 3
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`
`3
`
`

`

`US 7,761,127 B2
`
`Page 4
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`6,657,717 B2
`2/2005 Al-Ali
`6,850,788 B2
`12/2003 Diab etal.
`6,658,276 B2
`2/2005 Caro etal.
`6,852,083 B2
`12/2003 Wasserman
`6,658,277 B2
`
`6,661,161 Bl=12/2003 Lanzoet al. 6,861,639 B2 3/2005 Al-Ali
`
`6,662,033 B2
`12/2003 Casciani etal.
`6,869,402 B2
`3/2005 Arnold
`
`6,665,551 Bl=12/2003 Suzuki 6,882,874 B2 4/2005 Huiku
`
`6,668,183 B2
`12/2003 Hicksetal.
`6,898,452 B2
`5/2005 Al-Ali et al.
`6,671,526 Bl
`12/2003 Aoyagiet al.
`6,912,049 B2
`6/2005 Pawluczyk etal.
`6,671,531 B2
`12/2003 Al-Alietal.
`6,917,422 B2
`7/2005 Samsoondar et al.
`6,675,031 Bl
`1/2004 Porgesetal.
`6,919,566 Bl
`7/2005 Cadell
`6,675,106 Bl
`1/2004 Keenan etal.
`6,920,345 B2
`7/2005 Al-Alietal.
`6,678,543 B2
`1/2004 Diab etal.
`6,921,367 B2
`7/2005 Mills
`6,681,126 B2
`1/2004 Solenberger
`6,922,645 B2
`7/2005 Haalandetal.
`6,684,090 B2
`1/2004 Ali etal.
`6,928,311 Bl
`8/2005 Pawluczyket al.
`6,684,091 B2
`1/2004 Parker
`6,931,268 Bl
`8/2005 Kiani-Azarbayjanyet al.
`6,687,620 Bl
`2/2004 Haalandetal.
`6,931,269 B2
`8/2005 Terry
`6,694,157 Bl
`2/2004 Stoneetal.
`6,934,570 B2
`8/2005 Kianietal.
`6,697,655 B2
`2/2004 Sueppelet al.
`6,939,305 B2
`9/2005 Flaherty etal.
`6,697,656 Bl
`2/2004 Al-Ali
`6,943,348 Bl
`9/2005 Coffin, IV
`6,697,658 B2
`2/2004 Al-Ali
`6,944,487 B2
`9/2005 Maynardet al.
`RE38,476 E
`3/2004 Diab etal.
`6,950,687 B2
`9/2005 Al-Ali
`6,699,194 Bl
`3/2004 Diab etal.
`6,961,598 B2
`11/2005 Diab
`6,701,170 B2
`3/2004 Stetson
`6,970,792 Bl
`11/2005 Diab
`6,708,049 Bl
`3/2004 Berson etal.
`6,975,891 B2
`12/2005 Pawluczyk
`6,711,503 B2
`3/2004 Haaland
`6,979,812 B2
`12/2005 Al-Ali
`6,714,803 Bl
`3/2004 Mortz
`6,985,764 B2
`1/2006 Masonetal.
`6,714,804 B2
`3/2004 Al-Alietal.
`6,987,994 Bl
`1/2006 Mortz
`6,714,805 B2
`3/2004 Jeon et al.
`6,993,371 B2
`1/2006 Kianiet al.
`RE38,492 E
`4/2004 Diabet al.
`6,996,427 B2
`2/2006 Ali et al.
`6,719,705 B2
`4/2004 Mills
`6,999,904 B2
`2/2006 Weberetal.
`6,720,734 B2
`4/2004 Norris
`7,001,337 B2
`2/2006 Dekker
`6,721,584 B2
`4/2004 Baker,Jr. et al.
`7,003,338 B2
`2/2006 Weberetal.
`6,721,585 Bl
`4/2004 Parker
`7,003,339 B2
`2/2006 Diab etal.
`6,725,074 Bl
`4/2004 Kastle
`7,006,856 B2
`2/2006 Baker,Jr. et al.
`6,725,075 B2
`4/2004 AlI-Ali
`7,015,451 B2
`3/2006 Dalke et al.
`6,726,634 B2
`4/2004 Freeman
`7,024,233 B2
`4/2006 Ali etal.
`6,735,459 B2
`5/2004 Parker
`7,027,849 B2
`4/2006 AlI-Ali
`6,741,875 Bl
`5/2004 Pawluczyket al.
`7,030,749 B2
`4/2006 AlI-Ali
`6,741,876 Bl
`5/2004 Scecina etal.
`7,039,449 B2
`5/2006 Al-Ali
`6,743,172 Bl
`6/2004 Blike
`7,041,060 B2
`5/2006 Flaherty etal.
`6,745,060 B2
`6/2004 Diab etal.
`7,044,918 B2
`5/2006 Diab
`6,745,061 Bl
`6/2004 Hickset al.
`2001/0044700 Al
`11/2001 Kobayashietal.
`6,748,253 B2
`6/2004 Norriset al.
`2001/0045532 Al
`11/2001 Schulz etal.
`6,748,254 B2
`6/2004 O’Neil etal.
`2002/0021269 Al
`2/2002 Rast
`6,754,515 Bl
`6/2004 Pologe
`2002/0038078 Al
`3/2002 Ito
`6,754,516 B2
`6/2004 Mannheimer
`2002/0038081 Al
`3/2002 Feinet al.
`6,760,607 B2
`7/2004 Al-All
`2002/0059047 Al
`5/2002 Haaland
`6,760,609 B2
`7/2004 Jacques
`2002/0111748 Al
`8/2002 Kobayashietal.
`6,770,028 Bl
`8/2004 Ali etal.
`2002/0154665 Al*
`10/2002 Funabashietal. ............. 372/45
`6,771,994 B2
`8/2004 Kianietal.
`2002/0156353 Al
`10/2002 Larson
`6,773,397 B2
`8/2004 Kelly
`2002/0161291 Al
`10/2002 Kianietal.
`6,778,923 B2
`8/2004 Norris et al.
`2002/0183819 Al
`12/2002 Struble
`6,780,158 B2
`8/2004 Yarita
`2003/0109775 Al
`6/2003 O’Neil et al.
`6,788,849 Bl
`9/2004 Pawluczyk
`2003/0120160 Al
`6/2003 Yarita
`6,792,300 Bl
`9/2004 Diab etal.
`2003/0139657 Al
`7/2003 Solenberger
`6,801,797 B2
`10/2004 Mannheimeretal.
`2003/0195402 Al
`10/2003 Fein etal.
`6,801,799 B2
`10/2004 Mendelson
`2004/0006261 Al
`1/2004 Swedlowetal.
`6,810,277 B2
`10/2004 Edgar, Jr. et al.
`2004/0033618 Al
`2/2004 Haasset al.
`
`4
`
`

`

`US 7,761,127 B2
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`Page 5
`
`2004/0034898 Al
`2004/0059209 Al
`2004/0064259 Al
`2004/0081621 Al
`2004/0092805 Al
`2004/0133087 Al
`2004/0138538 Al
`2004/0138540 Al
`2004/0147823 Al
`2004/0158134 Al
`2004/0158135 Al
`2004/0162472 Al
`2004/0167382 Al
`2004/0176670 Al
`2004/0181134 Al
`2004/0199063 Al
`2004/0204639 Al
`2004/0204868 Al
`2004/0262046 Al
`2004/0267103 Al
`2004/0267140 Al
`2005/0011488 Al
`2005/0043902 Al
`2005/0049469 Al
`2005/0070773 Al
`
`2/2004 Bruegl
`3/2004 Al Ali et al.
`4/2004 Haalandetal.
`4/2004 Arndt et al.
`5/2004 Yarita
`7/2004 Ali et al.
`7/2004 Stetson
`7/2004 Baker, Jr. et al.
`7/2004 Kianiet al.
`8/2004 Diabetal.
`8/2004 Baker,Jr. et al.
`8/2004 Bersonetal.
`8/2004 Gardneretal.
`9/2004 Takamuraet al.
`9/2004 Baker, Jr. et al.
`10/2004 O’Neil et al.
`10/2004 Cascianiet al.
`10/2004 Maynard etal.
`12/2004 Simonetal.
`12/2004 Lietal.
`12/2004 Ito et al.
`2/2005 AL Ali et al.
`2/2005 Haaland et al.
`3/2005 Aoyagiet al.
`3/2005 Chinetal.
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`2005/0075546 Al
`2005/0085735 Al
`2005/0124871 Al
`2005/0143634 Al
`2005/0143943 Al
`2005/0148834 Al
`2005/0184895 Al
`2005/0187447 Al
`2005/0187448 Al
`2005/0187449 Al
`2005/0187450 Al
`2005/0187452 Al
`2005/0187453 Al
`2005/0197549 Al
`2005/0197579 Al
`2005/0197793 Al
`2005/0203357 Al
`2005/0228253 Al
`2005/0250997 Al
`2006/0030764 Al
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`4/2005 Baker,Jr. et al.
`6/2005 Baker,Jr. et al.
`6/2005 Baker,Jr. et al.
`6/2005 Brown
`7/2005 Hull et al.
`8/2005 Petersenet al.
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`8/2005 Petersenet al.
`8/2005 Chew etal.
`8/2005 Chew etal.
`8/2005 Petersenet al.
`8/2005 Petersenet al.
`9/2005 Baker,Jr.
`9/2005 Baker,Jr.
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`2/2006 Porgesetal.
`
`wo
`wo
`
`FOREIGN PATENT DOCUMENTS
`WO 00/59374
`10/2000
`WO 03/068060
`8/2003
`
`2005/0070775 Al
`
`3/2005 Chinet al.
`
`* cited by examiner
`
`5
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 1 of 48
`
`US 7,761,127 B2
`
`FIG.1
`
`6
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 2 of 48
`
`US 7,761,127 B2
`
`ft
`
`FIG.2A
`
`7
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 3 of 48
`
`US 7,761,127 B2
`
`FIG.2C
`
`FIG.2B
`
`8
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 4 of 48
`
`US 7,761,127 B2
`
`100
`
`MONITOR
`
`400
`
`(FIG. 40)
`MULTIPLE WAVELENGTH SENSOR
` 500
`
` EMITTER
`ASSEMBLY
`
`
`DETECTOR
`ASSEMBLY
`(FIG. 24)
`
`
`
`
`
`
`
`
`
`
`SENSOR
`INTERCONNECT
`
`CONTROLLER
`
`ASSEMBLY
`(FIG. 45)
`
`
`(FIG. 19)
`
`
`
`
`
`
`ATTACHMENT
`ASSEMBLY
`(FIG. 27)
`
`FIG. 3
`
`9
`
`

`

`Jul. 20, 2010
`
`Sheet 5 of 48
`
`US 7,761,127 B2
`
`U.S. Patent
`
`FIG. 4
`
`10
`
`10
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet6 of 48
`
`US 7,761,127 B2
`
`500
`
`EMITTER ASSEMBLY
`
`1200
`
`
`SUBSTRATE
`(FIG. 12)
`
`
`
`
`
`DRIVE
`
`4530
`4560
`
`
`EMITTER
`ARRAY
`(FIG. 7)
`
`EQUALIZATION
`(FIGS. 9A-B)
`
`FIG. 5
`
`11
`
`11
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 7 of 48
`
`US 7,761,127 B2
`
`{ 500
`
`
`
`FIG. 6
`
`12
`
`12
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 8 of 48
`
`US 7,761,127 B2
`
`COLUMN
`ADDRESS
`
`4560 COLUMN DRIVERS
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`4530
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`FIG. 7
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`13
`
`13
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 9 of 48
`
`US 7,761,127 B2
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`t700
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 10 of 48
`
`US 7,761,127 B2
`
`MONITOR
`SENSOR
`
`
`MONITOR
`SENSOR
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` 500
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`50
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`Wavelength (nm)
`
`FIG. 9
`
`15
`
`15
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 11 of 48
`
`US 7,761,127 B2
`
`700
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`1100 |
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`1
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`

`

`US 7,761,127 B2
`
`Sheet 12 of 48
`
`Jul. 20, 2010
`
`U.S. Patent
`
`FIG. 110
`
`17
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`17
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 13 of 48
`
`US 7,761,127 B2
`
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 14 of 48
`
`US 7,761,127 B2
`
`
`SOLDERMASK
`
`1200
`reg
`
`4301
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`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 15 of 48
`
`US 7,761,127 B2
`
`1200
`
`1532
` 1310
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`FIG. 15
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`FIG. 16
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`20
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 16 of 48
`
`US 7,761,127 B2
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`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 17 of 48
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`US 7,761,127 B2
`
`{ 1402
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`FIG. 18
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`22
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 18 of 48
`
`US 7,761,127 B2
`
`
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`
`

`

`US 7,761,127 B2
`
`
`
`ALVYELSENSLINDYID
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`U.S. Patent
`
`Jul. 20, 2010
`
`0061
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`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 20 of 48
`
`US 7,761,127 B2
`
`FIG.21
`
`4470
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`
`t1900
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`25
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 21 of 48
`
`US 7,761,127 B2
`
`2200 (7202
`
`2220
`
`FIG. 22
`
`26
`
`26
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 22 of 48
`
`US 7,761,127 B2
`
`
`
`FIG. 23
`
`27
`
`27
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 23 of 48
`
`US 7,761,127 B2
`
`2440
`
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`
`2442
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`2450
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`
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`
`2430
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`2210
`
`28
`
`28
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 24 of 48
`
`US 7,761,127 B2
`
`ft 2400
`
`TISSUE
`
`SECOND
`DETECTOR
`
`EMITTERS
`
`2510
`
`2520
`
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`
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`
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`
`700
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`FIG. 26
`
`29
`
`29
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 25 of 48
`
`US 7,761,127 B2
`
`i 2700
`
`EMITTER
`PAD
`FIGS. 30, 33
`
`2800
`
`3500
` 3000
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`
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`FIGS. 28-29
`
`FLEX CIRCUIT (FIGS. 20-24}
`
`
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`
`FIG. 27
`
`30
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 26 of 48
`
`US 7,761,127 B2
`
`ft
`
`2810
`
`
`2830
` FINGERTIP
`
`2820
`
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`
`2801
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`
`2840
`
`2802
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`2810
`
`FIG. 28
`
`31
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`31
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 27 of 48
`
`US 7,761,127 B2
`
`FIG. 29B
`
`32
`
`32
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 28 of 48
`
`US 7,761,127 B2
`
`i3000
`
`
`
`3080
`
`FIG. 30A
`
`{ 3000
`
`
`
`FIG. 30B
`
`33
`
`33
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 29 of 48
`
`US 7,761,127 B2
`
`
`
`FIG. 30C
`fo
`
`3080
`
`3070
`
`
`
`SECTION A-A
`
`FIG. 30F
`fC
`
`3010
`
`FIG. 30D
`ft
`
`FIG. 30G
`fC
`
`SECTION B-B
`
`
`FIG. 30E
`
`FIG. 30H
`
`34
`
`34
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 30 of 48
`
`US 7,761,127 B2
`
`FIG. 31A
`
`FIG. 31B
`
`35
`
`35
`
`
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 31 of 48
`
`US 7,761,127 B2
`
`
`
`FIG. 310
`
`3100
`
`a
`
`FIG. 31D
`yo
`
`
`
`FIG. 31E
`
`36
`
`
`
`SECTION A-A
`
`FIG. 31F
`
`3100
`
`“h
`
`FIG. 31G
`
`3100
`
`3160
`
`3160
`
`3150
`
`3110
`
`SECTION B-B
`
`FIG. 31H
`
`36
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 32 of 48
`
`US 7,761,127 B2
`
`t3200
`
`3220
`
`FIG. 32A
`
`3210
`
`FIG. 32B
`
`37
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 33 of 48
`
`US 7,761,127 B2
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`
`
`FIG. 32D
`fo
`
`3220
`
`FIG. 32E
`
`38
`
`t3200
`
`SECTION A-A
`
`FIG. 32F
`fo
`a
`
`FIG. 32G
`to
`
`
`
`SECTION B-B
`
`FIG. 32H
`
`38
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 34 of 48
`
`US 7,761,127 B2
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`FIG. 383A
`
`
`
`FIG. 33B
`
`39
`
`39
`
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 35 of 48
`
`US 7,761,127 B2
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`
`
`FIG. 33C
`ft
`
`
`
`SECTION A-A
`
`FIG. 33F
`tC
`
`ef
`
`FIG. 33D
`fo
`
`FIG. 33G
`tC
`
` SECTION B-B
`fal
`
`FIG. 33E
`
`FIG. 33H
`
`40
`
`40
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 36 of 48
`
`US 7,761,127 B2
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`FIG. 384A
`
`FIG. 34B
`
`41
`
`
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 37 of 48
`
`US 7,761,127 B2
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`
`
`
`
`SECTION A-A
`
`FIG. 34C
`FIG. 34F
`fo
`to
`FI ei
`
`FIG. 34D
`fo
`
`
`
`FIG. 34E
`
`42
`
`FIG. 34G
`ft
`p=
`
`SECTION B-B
`
`FIG. 34H
`
`42
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 38 of 48
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`US 7,761,127 B2
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`
`
`FIG. 35A
`
`FIG. 35B
`
`43
`
`43
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 39 of 48
`
`US 7,761,127 B2
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`t3600
`
`t3600 3630
`
`3620 ~|}3610
`
`FIG. 386A
`
`FIG. 36B
`
`a 3600
`
`3620
`
`3630
`
`3610
`
`FIG. 36C
`
`44
`
`44
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 40 of 48
`
`US 7,761,127 B2
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`
`
`FIG. 37A
`
`{ 3700
`
`t3700
`
`3730
`3720
`
`3730
`3720
`
`3730
`3720
`
`FIG. 37D
`
`FIG. 37B
`
`C 3700
`
`
`
`FIG. 37C
`
`45
`
`45
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 41 of 48
`
`US 7,761,127 B2
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`t3800
`
`FIG. 38D
`
`
`SECTION A-A
`
`t3800
`
`
`
`46
`
`46
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 42 of 48
`
`US 7,761,127 B2
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`fo
`
` 3912
`
`3910
`
`FIG.39B
`
`3900
`
`3910
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`3910
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`am
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`3920
`
`SECTION A-A
`FIG. 39D
`
`FIG. 39C
`
`47
`
`47
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 43 of 48
`
`US 7,761,127 B2
`
`O01D>oor
`
`00z
`
` MAWNASSV
`
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`QNa-LNOUS
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`YOLOALAG
`
`48
`
`48
`
`
`
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 44 of 48
`
`US 7,761,127 B2
`
`100 YY
`
`i“e4130
`
`tv4100
`
`
`ROW1
`p
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`MONITOR | CABLE |Y_4,3. SENSOR
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`SENSOR ROW'1
`COL2
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`4154
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`100 YY
`FIG. 41A
`4400 fo
`MONITOR
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`100 + FIG. 41B yo“ ye
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`MONITOR
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`COL
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`ROW2
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`COL2
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`COL1
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`COL2
`
`ROW’
`
`COL1
`
`ROW2
`
`FIG. 41C
`
`49
`
`49
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 45 of 48
`
`US 7,761,127 B2
`
`VEVDla
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`50
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 46 of 48
`
`US 7,761,127 B2
`
` N 4AsON 4470
`
`FIG. 44A
`
`FIG. 44B
`
`51
`
`51
`
`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 47 of 48
`
`US 7,761,127 B2
`
`?SGOHLVO
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`52
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`

`

`U.S. Patent
`
`Jul. 20, 2010
`
`Sheet 48 of 48
`
`US 7,761,127 B2
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`oO©oO
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`53
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`
`
`

`

`US 7,761,127 B2
`
`1
`MULTIPLE WAVELENGTH SENSOR
`SUBSTRATE
`
`PRIORITY CLAIM TO RELATED PROVISIONAL
`APPLICATIONS
`
`The present application claims priority benefit under 35
`USS.C. §119(e) to U.S. Provisional Patent Application Ser.
`No. 60/657,596, filed Mar. 1, 2005, entitled “Multiple Wave-
`length Sensor,” No. 60/657,281, filed Mar. 1, 2005, entitled
`“Physiological Parameter Confidence Measure,” No. 60/657,
`268,filed Mar. 1, 2005, entitled “Configurable Physiological
`Measurement System,” and No. 60/657,759, filed Mar. 1,
`2005, entitled “Noninvasive Multi-Parameter Patient Moni-
`tor’ The present application incorporates the foregoing dis-
`closures herein by reference.
`
`INCORPORATION BY REFERENCE OF
`COPENDING RELATED APPLICATIONS
`
`10
`
`15
`
`20
`
`The presentapplicationis related to the following copend-
`ing U.S. utility applications:
`
`25
`
`ho =eBHaa
`
`n
`Har = » Ena Ci
`i=l
`
`)
`
`2)
`
`where i,,, is the bulk absorption coefficient and represents
`the probability of absorption per unit length. The minimum
`numberof discrete wavelengths that are required to solve
`EQS. 1-2 are the numberof significant absorbers that are
`present in the solution.
`A practical application of this technique is pulse oximetry,
`which utilizes a noninvasive sensor to measure oxygen satu-
`ration (SpO,) and pulse rate. In general, the sensor has light
`emitting diodes (LEDs) that transmit optical radiation of red
`and infrared wavelengths into a tissue site and a detector that
`respondsto theintensity ofthe optical radiation after absorp-
`tion (e.g., by transmission or transreflectance) by pulsatile
`arterial blood flowing within the tissue site. Based on this
`response, a processor determines measurements for SpO,,
`pulse rate, and can output representative plethysmographic
`waveforms. Thus, “pulse oximetry” as used herein encom-
`passesits broad ordinary meaning knownto oneof skill in the
`art, which includes at least those noninvasive procedures for
`measuring parameters of circulating blood through spectros-
`copy. Moreover, “plethysmograph” as used herein (com-
`monly referred to as “photoplethysmograph’’), encompasses
`its broad ordinary meaning knownto one ofskill in theart,
`whichincludesat least data representative of a change in the
`absorption of particular wavelengthsoflight as a function of
`the changesin bodytissue resulting from pulsing blood. Pulse
`oximeters capable of reading through motion induced noise
`are available from Masimo Corporation (“Masimo”) of Irv-
`ine, Calif. Moreover, portable and other oximeters capable of
`reading through motion induced noise are disclosed in at least
`USS. Pat. Nos. 6,770,028, 6,658,276, 6,157,850, 6,002,952
`5,769,785, and 5,758,644, which are owned by Masimo and
`are incorporated by reference herein. Such reading through
`motion oximeters have gained rapid acceptance in a wide
`variety of medical applications, including surgical wards,
`intensive care and neonatal units, general wards, homecare,
`physical training, and virtually all types of monitoring sce-
`narios.
`
`SUMMARY OF THE INVENTION
`
`There is a need to noninvasively measure multiple physi-
`ological parameters, other than, or in addition to, oxygen
`saturation and pulse rate. For example, hemoglobin species
`that are also significant under certain circumstancesare car-
`boxyhemoglobin and methemoglobin. Other blood param-
`eters that may be measured to provide important clinical
`information are fractional oxygen saturation, total hema-
`globin (Hbt), bilirubin and blood glucose, to name a few.
`Oneaspect of a physiological sensoris emitters configured
`to transmit optical radiation having multiple wavelengths in
`response to corresponding drive currents. A thermal mass is
`disposed proximate the emitters so as to stabilize a bulk
`temperature for the emitters. A temperature sensor is ther-
`mally coupled to the thermal mass. The temperature sensor
`provides a temperature sensor output responsive to the bulk
`temperature so that the wavelengths are determinable as a
`function of the drive currents and the bulk temperature.
`Anotheraspect of a physiological sensor capable of emit-
`ting light into tissue and producing an output signal usable to
`
`30
`
`35
`
`40
`
`45
`
`50
`
`55
`
`54
`
`
`
`
`
`1
`
`2
`
`3
`
`4
`
`5
`
`6
`
`7
`
`8
`
`9
`
`10
`
`App. Sr.No.
`
`Filing Date
`
`11/367,013 Mar.
`
`11/366,833
`
`11/367,034 Mar.
`
`11/367,014 Mar.
`
`11/366,208
`
`Title
`
`
`
`
`
`
`
`1,2006 Multiple Wavelength
`Sensor Emitters
`11/366,995 Mar.1,2006 Multiple Wavelength
`Sensor Equalization
`11/366,210 Mar.1,2006 Multiple Wavelength
`Sensor Substrate
` Mar.1,2006 Multiple Wavelength
`Sensor Interconnect
`11/366,997 Mar.1,2006 Multiple Wavelength
`Sensor Attachment
`1,2006 Multiple Wavelength
`Sensor Drivers
`11/367,036 Mar.1,2006 Physiological Parameter MLR.O10A
`Confidence Measure
`11/367,033 Mar.1,2006 Configurable
`Physiological
`Measurement System
`1, 2006 Noninvasive Multi-
`Parameter Patient
`Monitor
` Mar.1,2006 Noninvasive Multi-
`Parameter Patient
`Monitor
`
`
`
`Atty Dock.
`
`MLR.002A
`
`MLR.003A
`
`MLR.004A
`
`MLR.O05A
`
`MLR.006A
`
`MLR.009A
`
`MLR.011A
`
`MLR.012A
`
`MLR.013A
`
`
`
`The present application incorporates the foregoing disclo-
`sures herein by reference.
`
`BACKGROUND OF THE INVENTION
`
`Spectroscopy is a common technique for measuring the
`concentration of organic and someinorganic constituents of a
`solution. The theoretical basis of this technique is the Beer-
`Lambert law, which states that the concentration c, of an
`absorbent in solution can be determined by the intensity of
`light transmitted through the solution, knowing the path-
`length d,, the intensity of the incident light I, and the
`extinction coefficient €,,
`at a particular wavelength A. In
`generalized form, the Beer-Lambert law is expressedas:
`
`54
`
`

`

`US 7,761,127 B2
`
`3
`determine one or more physiological parameters of a patient
`is a thermal mass. Light emitting sources are thermally
`coupled to the thermal mass. The sources have corresponding
`multiple operating wavelengths. A temperature sensoris ther-
`mally coupled to the thermal mass and is capable of deter-
`mining a bulk temperature for the thermal mass, where the
`operating wavelengths are dependent on the bulk tempera-
`ture. A detector is capable of detecting light emitted by the
`light emitting sources after tissue attenuation and is capable
`of outputting a signal usable to determine one or m