WO 2007/101158
`
`PCT/US2007/062815
`
`
`
`
`
`
`
`
`
`
`}}}}}}}3
`
`
`
`
`
`{SEOHD NG M87
`Sas’ Saal chy Gu Lie cys Ala fyy Ala Ale Oye ‘The Gly Maa! Seat Cya
`ty
`(SEOIO NC 2489:
`fe Ras’ Xas’ Sly Mn Pe Cys Ala Fyy Ala ala Cys ‘Thr Gly das! Oys Xaar
`rhe
`{SROIO Ren Ah ees
`ys Kat Rae? Bry BP Re yw AIR Bye Ale Ala Cys Thr Gly Cys Kast
`Ly
`{SEQAO Baga
`Bly. Tar Cys Ras! Kear Gly Glu We Dye Ala Tyr Ala Aly Cys TRE Gly Gye Kae! Yan?
`{BEOHD NOE 2484
`Qhy Yhe Cys Asar Gly Kaw? Glir tle ye Ala lhyy Ala Ala tye The Gly cys
`
`(SEQ NO: 2492
`eas Gy Xow! Sait Qu Tae Cys Ala dyx Ale Als Cyn tay sly cys
`hy
`Sas! Gly Taal xaat Rage Qiu Ge Cyr Ala tyr ale Ale Cys Thr Shy cys SHONe 2403
`Shy
`
`“yt Naw? hye
`ky
`“Hig Ras? Tle Oye Ala Tye Abi ALA Cee he Gy nye
`(SBE NO wat”
`}
`98
`: Ove
`525
`Ghy Mas
`Glu fle Sea’ Cye Ale Tye Ale Ale Oye Thr Gly ove
`{SEGHD NO;
`3
`. Tye Baa’ aly
`Siu tle Cya Xeat Sia Tyr Ala dla Cys TRY Gly Ove GEA AO: 2406 }
`HUY AGKT Gy Baa! Raa’ Glu Cle Cys Bia Naa? Byer Ala Ale Lys The Gly tye fataht, ed4er7 }
`‘hy Dyn Bxer Why Ras! Xaat Glu dle Cye Ada ‘tye Kaas Ala Rin Oye The iy cys GSEONG MO Seea}
`Raw’ Oy ABA’ Yaat Sia Kid oye Ala Tyr Ala Xaat RlA CYR "the Gly dye GGEOU NO:saap }
`faa’ oly Xaa? Jaa Glu Tle Cys Ala Tye Ala Ala Kaa’ Qyee Thr @y tys (ORD NG SSEN j
`
`
`Raa’ Bly Ava’ fant Siu Mn Cys Ala Tye Bis Abs Cye Naat Thy Gly oye ASEGHD Nee Vsth }
`Raa Biy Saat Yaut da rin Sys Aka Tyr Sis Ala Cys thr Xaa’ Gly cys
`gakQio NO 2bae }
`Rea? Gly Kaa’ Xaat Gly Ye Sys ala Tyo Ala Ala Cys The why Neat Cys
`(REQNTE DAR}
`Raa’ Wy Haat Yes! Glu Vie cys Ale Tee Ale ala Qes Une Gly cys Rea? EOIONO: BW |
`‘daa’ OYy Raa’ Glu Kael Fle dye Ala Tyr Ala Ala Gye Thy Sly Gye
`(SECHO NGL ZSOS: }
`‘Raat Ghy Maa? Wha Xéat Ras’ Tle Oys Ala Tyr Ma Ale Oye Thr Gly tye (SEGRE NO; 2808 )
`6
`Kaa’ Yly Maal Wie Kao’ Te kgat oys Ala Dr Kis Ala Cys TRe Glyoye (GEQID NO: 2507 }
`}:
`Raal Shy Nas! Gie Xaai die Cys Xus' Ala Tyr Bla Ala Gye Thy Gly Oys
`(SEONG NO: 2508
`Baa! Gly Nas! Gi Xs’ Lie Qye Ale Xaat Pyx Ala Ais Oyx The Oly ays
`(SHONO ARG
`(SERID Noh 2O10 )
`Mas! @ly- 29s? Gky Naat Yas Sys Ala Dye Raa’ Ala Bis Cya Thr Sly Gye
`Maat @hy tual @hi kaa? Tle Cys Ala Tye Ale Kaa’ Ble Cyw Thr OTy Gye
`IMEOIDNO: 2tt )
`
`Gy Yan! Gly Xan’ Tle Cys Ala Qe Ala Ala Naat Gye The Gly cya GRAIN NG 2512}
`Kaa! @ly Naa’ Gin Xaat Be, Cys Ala Tyr Ala Ala Cys Sas’ Thy Gly cys
`(SECRD ROCEES »
`Raai aly Naat Gu Xeat die Ok Ala Tyr Ala Ala Cys. Thr xaat Sly Oya
`(GEGNO: RBIs)
`Raa’ Gly Maat Gu kee! dle Cyt Ale DaMa Ale Gye The Gly Yas! cya
`{SSQND NO 2815
`- Naat @lp Xaat Gla kant Gle Cys Ala Tyr Ala Ala Cys The Gy dys Kaa
`(SRQUERO 2818.)
`Raa’ @ly Naat Gly Vie Seat cys Abe Tye BlaAig Cys Thy Gly Cys
`{SEQ NA 25}
`ys Sea@ly Ras! Plu Tie Sea Nast Spe hia rye Ala Waa Uys Thr Gly oye
`(GEQUENG: 2518 }
`Kaat Gy Xas! Sly The Kus" Cys Kaw ala Tye Ala Ale. Cys Thr Sly cya
`(GEOQNINO: 2549 3
`Kaa’ Gly faa! Glu fla Baa! Oya APS kaet Nyr Ale Ale Cys the Sly Gye
`(HRGHD NO: 2820 }
`FIG.
`isheet 48 uf itd)
`
`MYLAN - EXHIBIT 1022 Part 5 of 16
`1394
`
`1394
`
`MYLAN - EXHIBIT 1022 Part 5 of 16
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`

`

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`WO 2007/101158
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`PCT/US82007/062815
`
`66/226
`
`
`Cys Sins! Gly Naw’ Glu le Xaat Sys Ala Vy Raa! nla Ala cya The Gly oye (SGNosed }
`y Cya Nag? Gly Ned? Glu Tig wad’ Cye Ale Dyz Ala Raa’ Ala Oye The Gy Dyes
`(SEORO 2822 }
`Pea d
`Oye Ssal Shy Sant Slo Me Naat Gp Ala ‘yx Ala Als Mast Gye The Gly Oye {SEQHO:
`2529
`
`Bre
`
`Ye Sye Kent Gly Xeat Gia Tle Max! Cya Ble Tyx Ala Ala Cys-Naa! Thr Gly cys MeOIO NCBead
`feof
` Be ub
`y cya
`by
`x
`2 Ile Xea? Cys Ala Tye Ale Ala Cys ‘Te Raa! Olly Cye.
`GEOG Ato8es }
`if
`
`{SROQH3 NOL 2828
`he Oya Kant Gly Kaa! Gia Tle Xaat Cre Ala Tyr Ale Ala Cys Thr Sly xas' Gye
`8
`Bree
`pealys Kaa Gdy xaal Stu cle Xpat Gye Aka yr Als Ale Oye The Oty Cye Eaae
`ere
`:
`{SERID NOL2ear
`Peo Gh
`ONO AOL 232
`% )
`
`Cys Nas? Gly Naa! Qa Tie Cya Kaa’ Ala‘tyr Ale Ala Oys ‘The Ghy° Oye
`(st
`20}
`
`{Se
`3? G3 TNs Gye Kast daat Ala dyr ala Ble Cpe Thr Oly Cys {SEOM ND: 2829
`cys
`Bro ¢
`30)
`1 Gi The Cya Ksat Ada Raa? Tye Ala Als dye the Sly ye (SEOIo NO: 25S
`Nan?
`of
`Bro ¢
`y Oye
`Gye EGO NO RH
`¢ fys Ses® Uly Now! Gu (ie Gye Xaet Albu Tyr Kaa’ Als Ala Oye Thr oly
`p tye asa! Gly. Sag! chs die Gye Raat Ala Vyr Ada liad! Ala Oye Thr Ghy fac (SESHNO: 3622
`(SEQR NO: 2833
`P OYS Kee' Biv Kea’ Gia Die Cys Baa? ala Tye Als Ala Zea! Cex ‘Ne Gly Cys
`
`(SEQNEY a5
`tye Kast hy kat Glu Da tye Rast Aka Gyr Als Ala fys Qos? ‘the Gly oys
`fae Gly Cys GSEENE NO: 2585 }
`ye Kae Sly Kaa’ Glu Tie Oye Saat Ala Tyr Al« Ala Oys
`‘hr
`Be
`xy 4aa! Glu The Gys Kant Ala Tyr ale Mla tye *
`B Why Kea? Oya SECOKO:2826
`She Cys Raat &
`iySys Yaa?
`y Cys Raat &
`[SEQUYHO: 2bU7
`Ly Haat Qh Vin Gye as Als Tyr Ale Ala Cye
`&
`tye fas! Gly Nas! Gu Ike Gye Als Sus! Tye Ala Ada Gye
`Sly cys
`(SHOW: NO: ae
`8Sf
`
`
`y Cys Bad Gly Yas! Glu Tle ye Bla Sea! Xaal Tyr Ala Ala Cys
`The Giy Cya’
`(SRGINOL 2598
`tye Yau? Gty Nea’ Gig we cys sla: Kaa’ Tye Xwa! Ria Ala Cys Thr Gly Oye
`(GEcHD Ney eese
`Y Oye Raa’ Bly Neal Wy Tie Cys Ala Xaa’ Dyr Als Kaas Ala Oye She Gly Qye
`(QEQID Nth 254) }
`Dye San! Sly Raat Gldle Cys Ala Kee! Tyr Ala Ala maa? Oys Thr Ghy Oye
`(GEGID Ni2842}
`Ness Real dye Keath ola yie Gee Ale Kaat Tyr Ala Bla Gys Real thr tly fys
`(SEQIE NOs 2843 ,
`foe Ses Baa Sy Tan’ Gli Ile Gye ala Moa! Tyr Ala Ala Cys Thr kas? Gly cys
`(SEONow asad }
`Dye Raat Sly Aeal Gin Tie Cya Ala Naat Tyr Ale. Bln Cys he Ghy Jaal Uye SEONO: ges
`Bye Naa’ Bly aaal G1U Te Cys Ala Nas! Tyr Ale Als Cys Thr @ly fyn Kaw’
`(SECO NO: B48 |
`iy Raa’ Bly Kaa’ Glo Tle Cys Ale: tyr Raat Ala Alu Cys Tix GLY cya.
`iSECKO NCe 2eet
` fye kaa sty Kad? Ola We flys Ola yx Bae? Kaa’ hla Ala Cye “Far. Oy dys “(SENDNO:
`8us
`
`eyo Jan! Gly Raat Glu fe cys Ala Tyr Yaa! ala Maa! Ala Cys The Glycys {seoNoss
`Oye Bar’ Oly Raa’ Gly Tle Cys Ale Tyx Naat Als Bla Maa’ Cys Thy ¢aly cys
`{SEQNG aS
`x
`Ry. Cyn Mew’ Sly Raat Qiw Tle dye Ala Tyr Maal ala Als Qyew Naa! The Gig Cye
`(SRO NOxEES
`Cys Rawk
`Xie cya ala Tye Kaa’ Ala Ala Cys ‘thr aa’ Sly Gye
`{SRCHO NCH2602
`ip
`
`{SRQID RO. 285
`Gly Phe Oy Saat
`de cys Ala tye Kaa’ Ala Ale tys the Gly daa? Cy
`SEENDNOY asi
`Zhe Cys Ala Tye Naa! Ale Sia Gye Thr Oly cya gaat
`fue Gly thr Oyo Ava? Giy Real
`FYG. 2
`(stead49. of 114)
`
`iRioSaoFiataAPeedaeontoa
`
`x Y
`
`)} )i
`
`i)}} } }} }e
`
`1395
`
`
`
`1395
`
`

`

`WO 2007/101158
`
`PCT/US2007/062815
`
`67!
`
`220
`
`
`
`
`
`Kae’
`‘Kae’
`Bly
`Wye
`RaatRaat
`By
`ABR?
`Gy
`Rea
`aly
`maa
`Sly
`San‘
`aby
`Kast
`ay
`Xaat
`aly
`Yass?
`wy
`Sea?
`whys
`Rae?
`say
`Raw?
`thy
`Raat
`tty
`Xeat
`3 Qhy
`¥aat
`‘aly
`Xaat
`gry
`Krat
`Gly
`Kaa’
`Siv
`Aaa
`Sly
`Gly: Bas
`Ghy
`uy
`oy.
`Oty
`iy
`ay
`
`Kaa’
`ms Kaa!
`aast
`S Ray?
`Aga’
`Ra?
`Xaat
`Mast
`Sas!
`3S Kaa’
`Maa?
`. age?
`Raa?
`Rar?
`
`We Raat Shy
`
`“BirayAyn
`wetete
`GYbepeetey
`
`ra]
`
`1396
`
`ISEQIO NOL 2885
`OEQIY Nex. 2530
`?
`(SEQNT NO: 285
`
`(SHOE MO: 2558
`(BEQIG NO: 2853
`(SEQ NO: 250
`{SSOI0 NO: 258+
`{SERNNob gsed
`
`{SENNO NER Heee
`(SEOIG NO: 2564
`(SEO) NO: 2885,
`{SEOIO NO: 2888
`{SEND Nesey
`
`{SENN N
`266)
`(BBQ WO: 2568 )
`(SEQNO: 2570 }
`(Sau NOrgers
`|
`(SEGNG:
`2872 }
`(SED Nee 2873 }y
`
`“{(SEQND Nk Z
`{SEQ MOCASTS |
`CORONOS R678
`(SSONO: gare
`(SERDNG:2578
`{SEQRDNY: 2578
`(GHD Nok 2580
`{SEONk 2884 }
`(SEHQRY WA2582. }
`(SEQHO NE2888 )
`{SEQNe BBs }
`{SEQ NO: BERG }
`{SERN NIK. 2586}
`{SEQNE 2687 }
`(SEGRE Nise 2588 7
`
`j}}}}j}}
`
`: 5}}} }}
`
`iss
`' Ale Oys ‘The Gly cys
`ye Ala yx 3
`Rla Tye
`Baa
`' keal Bi a Cys Thar Gig oye
`Als.
`Rad
`) dda Rest Cys The Giy oye
`Kaa
`5 he
`Alda Tyr
`Sys Nes’ The Ghy Uys
`Fe Kaa’ Gly Cys
`Kaa
`‘* Sha Oye
`Ala tyr
`Raa
`Bho Tp.
`{ Ale Sys Uhe Gly Bae!
`tye
`Xaa
`Als
`Sis Ver
`Giy Sys Kass
`Als Cys he
`- Baa
`BAS
`iys
`Ale tyr
`“Bla
`the Gy tys
`Ka
`Alix
`Asa!
`Ada
`* Dyas Thr Sky Ove
`a Ala Tyx
`Kaa?
`Ala
`Bia
`Oye
`e Ale ye,
`eat The Gly Cys
`Kan‘
`Ala
`hha
`yew
`Ala tyr
`Thr Keats Gly Cys
`Ala
`Ble
`kaa!
`oye
`Thr Gly Bae? Cys
`Ala Ry
`oye
`Rat
`Ba
`Ala
`Ss Sie Tyr
`Thr Gly Cye tas’
`Bla Fox
`Sia
`Ala
`Cys Mae’?
`fhe Gy Ove
`28
`Ala
`Sys Kaa’
`ALR Tye
`yeat Yar Gy ope
`Ala
`hia
`Cys Aaa’
`B Bla Tyr
`Thr Xaat Gly Cys
`Bis
`Ala
`Cys faa!
`es Ale Tye
`The GlyNaat cys.
`ALS
`Rls
`Cya Nos!
`Yar Gly Gye Xeat
`cys Aka Tyr
`Ala
`Bia
`Cys Ala Tye
`Cys) thr
`Raa’ Gly: tye
`Raa?
`Ala
`Big
`Cys ‘thr.
`Kant Gy ogy
`oye Abe Tys
`Xaa‘
`Ala
`Aha
`Oye ‘ein
`Shy Xaa’ oye
`oye Ala TYs
`y Ale
`Raat Gly Oye Kagt
`Sys The
`Ala
`ays Ala
`Ty
`Ada
`TAS
`Cys Thr
`dys Blea 4
`Biy Kaa oys
`Sly Xaat Kan! Coe
`Sys the
`As
`Ada
`tye B28
`Ala
`Als
`Oye. The
`Gye Ala
`Giy Kast Cys Maat
`Akt
`aia
`Qys ‘Thr
`Gyn Ala Tyr
`Gly Oye Raa?
`Aka
`Aa
`Gly Cys Raa? Zant
`vys Thr
`Cyn Bla yz.
`Rha
`Aha
`Qly Oys.
`Cys tux
`Cyt Bla tyr
`Dis tye ALa tyr Ala Abel oye The Gly! cys
`& Cys ix Gly Ove:
`Maa! TLe-Cys Ads tyr sia Al
`& Cy Thy ly Ce
`Ele Xaa? Cys Ade Tyr Sia Al
`fhe
`Cyn Kea’ Ala Tyr Bla Al
`a Cye Shy. ly pys:
`she
`oye Ale Xaal Tyr ale
`a Cye Thr Gly Cys
`a Sys The Gy Oye
`Hho Oya Als Vyt Asat Ale Al
`FIG.2
`iebeet 60-0f U4)
`
`
`
`phe
`
`Rhu
`Bhu
`as 3
`ao. Mes
`gis |
`sic |
`She ft
`Shawy
`Sha XI
`
`
`
`Te
`Ble
`Re
`Xs
`Aw
`tle
`he
`te
`fie
`he
`tie
`Be
`Sea?
`
`Saa ‘
`Xaat
`Beat
`Nas!
`
`
`
`eas
`Ra
`Ghhis
`cytSPAY.
`IQ Kea‘
`‘Ble Zral
`haa‘
`Bu
`SEY
`Raa!
`aa’
`Shu
`Bin
`Raat
`te Kaa?
`
`1396
`
`

`

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`PCT/US2007/062815
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`68/226
`
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`
`: Cya Nes! Gly Glu Kaa! Nast Ue Cye Rls vyt Ala-Sav! Ala Cys THY @ly cvs
`f Cyn Rae? Gy Wa Kaa! Seat Wer Ove AL& ye Ada Ala Xue? tye Tee Uly tye
`B Cys Kaa OLY
`Gy hia? Kaa’ Eke Gps Ala DyrAla Ala Oya Nas! The Shy cve
`y Cyn Zaal
`Xan’ Kdat Pie Cys
`aha Ter AlR Ala Cy Thy Rue? Sly Ove
`x
`Dy Kar’
`Naa’ Xan’ te Cve Aja Tyr Ale Ala flys ‘Shr Gly Naa! aya
`oys Kaa Bly
`ant Baa? Ya Oya Ala ‘tyr dle Ala cys ‘thy ely les Kast
`hy
`Ue Cys Raat aby
`1eaas The Zant Oya Bla ys ale Ata oys Thy ayy OSs
`Bye
`dla
`The Gyy Naat
`GRy
`Sew? Se kaa Bayt Cys Ala Tyr Ala Ala dys Thy Shy oye
`Sky
`Cys Host Ghy Glu Naa’ Le Yas! Cys kag’ Bla tye Als Ala Cys Tur GlyCys
`Gly
`Gye Naa! Gly Gla Kea! Ta Xawt dye Ala Nast Tyr Ale Sle Oye thr Gly oye
`Thy
`SLy
`Phe Cys Xa? Gly Blu Kaa’ Pie Kea’ Uye Aka Tyr. Nas!’ Ale Aly dye The Ghy ops
`Bly
`Bt yoThs ays Kaw hy Slo Kaa’ Lis Raa? Oye Sls Tyr Ale Aas’ Aba ya Thr Sty. dys
`Bly The Oys Kaa aly Gia Xas* The Kees Oye Ale Dvr Ala Als Kaa? Oys Tar Gly tye
`Siy The Oye Kaa’ Bly Glu fast The Kaa’ Pye Ala dyer ala Ale Cys Xaal
`the Gly tye
`Giy Rig Cys Raat Gly Gly Mast Fhe kaee cys Ala. Tye Als Ale Oye Thy kaa! Gly cys
`Shy The Cys
`Raat
`hy
`Haat The kaat cys Aka Syr Ala Rha Cys Thr Gly vasa’ cys
`Sty ther:
`ys
`Mast Le Kant Cys Aka Sve Ala Ala Oya ‘She Shy(ye Nea!
`Shy vhe ¢
`i
`gf. Naa’ Tle Gye Naa! Mia TyeAla Ala Oye The diy oes
`Sky The ¢
`Ly
`Mas’ Yle Cya Kaw’ Naat Ala tyr Ale Ala Cys The G1} cya
`Shy Phe ¢
`ly Gig
`Kae’ Pla Cys Kaa! Als Kaa’ Tyh Als Ala Cys The Gly tye
`Giy Tae
`iy
`Kan’ 226 Sye Kage Ala Nyy Maa’ Ala Ake Oye The Sly oye
`Bem Gly ye Cys Naa! aly Gia Keat Tle Gya-Kaa’ Aba Tye Ale Mast Ala Sys Thr oly cys
`Bre Gy The Cys Nea! Gly Gia Kael Pie Cya Kaa’ Ala Tyr Ale Abs Aaa’ Oye The ely Cys
`Bea Gly THe Cys. Neat Ghy Gia Kaat tle Cys Zaat Ale DykAle Ale. cyy Naa! TheBLY Gye
`Pre UWly The Cys. Asa’ Gly Gla. Kaal Lie Cys Aas’ Ale Tyr Ale Ala Oyx ‘Pir kaal Gly cys
`
`dea ty Por Oye Nas? Gly Blu kas’ dle cya xed’ Ala Tyr Ale Ala Gye Thr Gly Kaa’ oye
`
`Seo Uy Thr Oya saa? dy Wha Kast Tla-cyw waa! Ala ye Als Aka Cys The
`Gly dye Kaa!
`
`£18 Cya Ala Ade! fyx Ala Ala Gye Thr Gly dye.
`Ben Gly THE Oye Aaa’ Gly Sle Kee!
`ROO Gly The Gye Naat Gly Glu daa die
`dyad als Saat Naa! Tyr Ale Ala Cye The Gly oye
`Heo. Gly The Oye Nsw? Gly Siu Kaa Cle Cys Ala Kaa’ Tyr Kaa’ Ala Ala Cys The Gly oys
`Bro dily hy Oye Ska! Gly Gla Naa? Tle dys Ala daa‘ ‘tyr Ale Aas? Ala cys The Gly ove
`pud- Gly Yhu Cys Nee’ Gly Gh Nea! ke Cys Ala Kaa!
`‘tyeAka Ala Kaat Cys Throuky Gye
`fro Gly Thy Cys Nae! Gly @iw Naat Tle Cys Ale Raa! Tyr Mla Kla Gye xaaé Phe Gly Cys
`Rea (hy The
`y Blu Kaa? Lie Cys Als Kaat Tyr, Ala Ake Cys The Rast Ghy Ove
`
`FIG. 2.
`_{stwet Af af 114y
`
`(SEOIR NO: 28
`{SERKDNO £94
`{SENG Nex E84
`SEGAO NO: 2882
`
`
`
`{SEONO: 2808
`(SEOID NO: 2897
`{SECO NOr AKA |
`{SRQID NC25u0. }
`SMe Nek 2800 }
`USHCHEY NCeA804 4
`(SEGRO NO; 2602. }
`{SEQNG: ZH}
`(SEQNO: 2804 }
`{ROD NO asos}
`SEO NO: ge08 }
`PREONO NO; Bea}
`{SECRD NCe 2508 }
`(GENO NG 2800}
`{SHAIR ROC BB1B }
`SEQ NO: 2814 }
`{SEQNO: 8842 }
`(SEG NO: 2614 }
`SEOIO NG 2814}
`(SEGID NG: 2815 )
`(SEQR ANG, 2816 )
`(SECO NG 2817 }
`{SELND NOL 2618 }
`(SEONG NO: 2618 }
`{SEQNOc RRO }
`(SEQW) NO: FHE7 }
`(BRaD worseer}
`
`
`
`1397
`
`1397
`
`

`

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`PCT/US2007/062815
`
`69/22
`
`6
`
`ISEQHNO, wHe9}
`{ERO NO: tas }
`{SEQW RG: 28285
`{SEQHY NO: 2526 }
`(SEQNO: Baz?
`(SEC8G. NO: 2838
`(SEND NO e209 fF
`{SRM NCh ZEIGE
`(SEQUD AEH Gea}
`28a
`(SEQID NB:
`(SROID NOx
`£3833 }
`{SEOIn NO:
`2534 }
`{SEED NOs 2638 |
`{SECKD NOM ese }
`{SEQID NO 26a? }
`{SEI KO. 2eaR }
`(SEONO: 2888 }
`(SEQNOs 2640 }
`(SEGNO: 2847 }
`(SESHO NOh Wide
`SRONok 2043
`{SEQHMO; 244
`(SRON0 NO: 2845
`(SEQIO NO: 2646
`(SEQID NO: 2647
`(SEGA NO: 2648 }
`(SEGID NO: £648 }
`
`{SEERNek 2886 }
`{SEcuD Neh 2687 }
`(SEED NO: 266d )
`SECU Nth 2603 }
`(SEQIO NCh2684 }
`{SEQIO NG: 2885 }
`SEEMD NOs 2458 }
`
`}}} e
`
`tetNeSeeNetttoe
`
`}}
`
`Ala Als
`oye Tee Sly
`tye
`Rar’
`ALG Aaa’ tyr
`aha
`Ala abe
`Cyn faa
`Kaa’ fer
`dye The Shy
`els
`Raa?
`Ala ala
`tye
`oye Thy
`hy Cys
`ala
`Tyr Kaa
`Gly Cys
`Kaa’ sla yds the Thy
`ALR
`Bla
`Iyy Zaa
`Mant ala Cyd ‘thy
`Sly Uys
`Ale
`Ris
`Ahi
`fyr Naa
`Xae’ ys Tie Gly Oya
`Nyxys Baal
`Ahe
`Ala
`Ala
`“NQye Raw? Thy Gby oes
`XRa*
`Klis
`aia:
`Aha
`Tyr. x
`Re Thy Kaat Gly Gye
`Sis
`Ada
`dia
`Ter. Xeat
`Cys Thy Gly Zaa‘ Gys
`sla
`aka
`Ala
`“Tyee kaa
`‘Sys Thr Gly Oya xdae
`ALS
`Kan’
`Sle F
`tys Thr @ly cys
`Bye. AIM
`Xa«
`Vyy Ala
`Ala
`Rae? Ala Ow ser
`ALa
`Maa?
`Ala
`Xaay Oye FRY Gly tye
`Tye Ada
`Ala
`maa?
`ale
`ays Ria
`eye Maat Yar Gly Ors
`Baas
`ala
`Ala
`tyr Als
`Dyn Thy Kea? Gly cps
`2a
`aka
`Kes?
`ys Thy Gly Naa’
`Cys
`Tyr Als
`Ala
`Ala
`Rag?
`tyr Ala
`Sys Yer Gly Cys Kee!
`tye.
`Cys
`eo hye oy
`ALB
`Maa’
`
`Als
`ala
`is
`Ag
`dat”
`Yaat
`tye
`Sash Cys The Gly Oya
`Ala
`Xsa*
`aka
`tyr Ala
`ya Xaas The Gly oyx
`Ras!
`58
`als
`Tye Rka
`Cys The Basar Shy Cys
`sae
`als
`ALS
`Tyr Ala
`Gya thr Gly: Kael Cys
`Kant
`Aya
`A RPA
`its Ter Gly Oya Kea?
`aye®
`‘ast
`Rls
`Ala
`tye Aaa
`“The Gly. don
`Naas!
`Ale
`ays
`BAYS
`Raa’? The Sky Cys.
`AYA
`Ala
`XAas The Keat Gly Cys
`Ws
`Ala.
`aye
`Kant Thr Gly faa) ors
`axa
`Rls
`aye Bla
`Mas? Thy Gly cys Kees
`ALR
`ALR
`Syt Ala
`he Raa? Gly oye
`Als
`Als
`ro
`Tye Ala
`‘Thy Saad Kaat Shy
`ALS
`Ala
`THE. Aaa! Ghy waa Oye
`Sy S54
`Ria
`He
`| Ala
`Thr Xda! Gly Ove Zaa
`Als
`Ria
`ayn &
`The hy Xaat ‘Oye
`Bia
`Ala
`tyx ale
`TheGly Kaa’ Nasa tye
`
`Sys:
`cys
`cys
`Gye
`Cyn
`cya
`oye
`cya
`Gy<1
`cya
`
`>.q
`
`¥IG.2
`(sheet 82 af 114)
`
`1398
`
`Elbobeterov
`
`crane
`Tis oye
`HAR’
`Raat
`oye
`Kaa’
`Tia Gye
`Aaa!
`Ile Cya
`Beat
`2 Os
`Xeat
`tis Sys
`Kant
`Cys
`wea?
`die Cys
`i Mast
`Cpa
`deat
`|
`ya
`Duss?
`Gys
`8 Cy
`yay?
`ci est
`2 yes
`Xan?
`y Ove
`i Fast
`Rye
`e YB
`Kar’ x
`Kast
`She Oya
`tL Kaa’ X
`Cee
`Kar’
`SPR
`Kan‘
`the Gye
`mane!
`cya
`“ant
`2 Cys
`y Rast
`Ty
` n OYE
`£
`s Dye
`SOB
`The tye
`8 ys
`S OYS
`Cys
`oe
`he Cys
`e Ws
`Fle. cys
`
`Baa!Raat
`xt
`vie Nas!
`SS!
`saw!
`iy Naa!
`2 Yaa’ 2
`. fae
`Xant
`Raa’
`
`ae
`ye
`
`
`Xaas MS, Baa!
`
`Raat
`
`¢
`
`thy Oye Kea
`Uys. Zant
`ve Raw?
`x Cyn Naa?
`Raa’ |
`y tye
`Kant
`x cya
`xaat
`ey
`PoUys dacs!
`x Uys Aaa’
`HY Cys Nas!
`in Cys Hag?
`tit, Oye Saat
`RU Cyh a?
`Ar. Oye Naat
`hy Oys Aas?
`Oye: Basa?
`§ Bsa?
`co oM Saas
`xea?
`Mass
`y Kaas
`% Keet
`Xee'
`He Raat
`
`y The Oye Rea’
`
`x 3
`
`eis
`
`3.
`
`
`
`
`Kar’
`RAR’?
`e
`YS Kaa?
`ve Oye: Kaa?
`rete Kae?
`
`*y
`
`1398
`
`

`

`WO 2007/101158
`
`PCT/US2007/062815
`
`70228
`
`z2
`
`y
`
`ISROIN NOeesT $
`veo Gly The Oye Kee' Oy Glu Nos! Tle Cys Ala tye Ble Ala Cyea Thr Oly Saal Cys Kaa’
`ISEDID NO? 2458 }
`Peo Oly Thy yg Sag! @hy Gi saat Mle ys Aha TySin Ala Gye The Oy Cye. Xa!
`(SERIO NONgeda }
`PNG Uy Thy Gye Maa! Gy qh Ree’ Re Uys Ala Tyr Ala Ala Oya ‘the @ly. Cys Ase’ Kees
`(SECO. NUE 7980 }
`$ro Gly Yhy oye Yar? Gly iu Ye laa’ cys ala Tye alg Ala cya Thr Gly cys
`(SEONO: 264 }
`by
`% Kaa! Bly Glu Lie Rea? Kaa Cys Ala Tyr Ma ale cys Bhe oly Cys
`z
`(GEQONO: 2662 }
`Kaa! Sly Giw Ele Raa’ Kaw! Raa? Cya Ale Tyr ala Mla Cys The Gly cys
`uaa’ Wy Glu tle’ Aaa? Raat Cys Kaa’ Rls Tyr bla Ala. Oye vhe ah
`{SEOID Ros 2882 }
`y Sys
`We.
`Ban’ Gly
`Siu fhe Naat Kaa’ Cys Ala Nag! gyn ada Ala Cys Phy ol
`y Sye (SEQINNO: 2004}
`ae
`¥
`}
`dye
`(SRONO: 2885
`RRR? ky GIR -Lle. Nad! Seat tyes Sada tyr Raat Ale Ala cya The Ot
`oe
`¥
`Raat Gly Bh
`Mont Rear Qyw Ala Ty Ala Maa! Als Cys ‘the Gly tye (SiO NO: 2868 }
`Raa’ Bly
`Tig Xag! Aaa’ Cys Aly tyr Ake Ala Kaa’ Gye Ter Ghy Cha
`(SEQID NCH a6e7 }
`Ren Oly The Cea Raat Sty
`Kags’ Yaa? Cvs Bla Tyr Abd Ala Ops Ras! Thy Gly Cpe
`(SEORE NO! 2960 3
`™bet x
`ne hoz
`Bree Gly the Gye Xa Ghy
`Kaw? Naat Cys
`Tye Ala Ake Cys The Xaat Gly oye GHOINO: 2860.)
`ot suet wt
`Kaal hy
`Kaw’ Sent Cys Ala Tyr Ala Ala Oya The Gky Baa’
`tye (SEONG: 2670}
`
`
`‘
`Kae!’ Gly
`Giv “(le Kaa’ Saat Cye Ada Tyr Ada Ala Cys The (iy
`dys daat
`¢
`Pro
`s kant”
`{SE
`}
`Ata Tyr Als Ala Cye The Siy cys
` Yaa’ Sys Xda
`
`Bra ah
`(GEONO: 2879 }
`Kast @ly Gly Tle Xaa! Cys Aan’ Bax! Aka tye Ala Ala Cys The hy Cpe
`Pra hy
`Maa’ Oly Bla Lla ast Cys New Ala Aaa’
`‘tyr Ala Ale CysThe Giy cya OEONING: 2674 }
`Pye
`Yxar, Gly Bia Tle Awa’ Cys Neat Ala Tye Kaa’ Aka ALA Cye The hy Oye
`(SEHD NO: 2678}
`Xan’ Gly Gin Tle Mea! Gya Nawt Ala Tyr Ala Raat Ala Cys The Gly oye (SEQHD Ack 267e }
`Beret
`
`< Kay’ Sly Ge Tle Xeat Sys Kea’ Ala Tyr Bla Bis Raat Q's ther Gy cys
`(SEQNO: 2877 ?
`sro s
`ro SU) The Cys Kart Gly why fle Kaa’ ya Sea’ Bin Tye dle Bis Gye xad? “The Gly Cys
`(EOI NOL sara }
`
`ISEQHO Noy wave}
`dle Nea! Cys kaa Ala dyr Als Als Gyo Tht Gly Nad? Gye GECHO NEE 2Had)
`Kaa
`fhe Raat Cys Xeat Ala tyr Sis Ala Gye Tue Gly Sys Kas’
`(SECNO Nob dédt }
`“¥a0°
`tle Joat Cys Bla Was? Tye ala ala Oye Tir diy dye
`EMO NO BHR
`&y
`kaat
`e Mag? ye Sin Naa’ Raat
`Tyr Ale Sia Cys Tar-Sly Oye
`(ECHO NOK 8683 ;
`Kaa® &
`e.kaet Gly Giw Le Yas! Mya Bla Saal Tye Naa? Ala ‘Ala Opa THE Gly Dye {SEQ Nik gaa }
`Sse’ By Gla Tle Naw! Cy Ala Nae? Tyr ale Seat Ala cya The Gly Cys
`(SEO N28|
`‘Kaaé aly Gle tle Naat Cys Sie Nsw! Dye Hla Ala Nast cys The Shyoye (GEQW) WO: 2086 }
`st Aaa’ Gy @lu Tle Maa? Cya ‘ale Naa’ tye Ale Aka Cys Raa’ She Wy tye (EQ NO: 2037 }
`3s kaa? Bly Biv De kaw! Cys ala Nag’ ye Bla ale cys var Raa’ Oly Cys BQW.NO: ga88 |
`y Vie Ops Aaa! Gly Glu The yas! Cy Ala Kea’ tyr Ale Ala Sys Fhe Gly Naa’ Cys
`(GRONOC 6R8 3.
`yids Dys Kaa’ @ly GlTle Kea’ dye Ale Saat TY Kia Ala Dys Thy Gly Cys Xaat
`{EQIONO: gaan |
`HIG. 2
`isheet 53 af 14945
`
`me aym Be%wywoweo Mm+ %
`D2es
`eeortbea&
`
` fen Sly The cys Maat Gly Gig Tie Eka Cyw Xaal Als fyr Ala kla Gye thy Kaa’ Gly Uys
`
`a o3em
`
`
`
`
`
`
`
`
`
`
`3
`3
`ae
`8
`3B
`
`3
`
`1399
`
`1399
`
`

`

`WO 2007/101158
`
`PCT/U82007/062815
`
`
`(SEGIONO: 2719} y Yhr Cys Naat Gly Ghy ie Kaa’ Cys Ala Tyr Ale Ala Cyd The Mast Shy use! Cya
`
`{SEQHNO: 2504.)
`Meat Ghy Shu che Naa! Cys AiR Fyk Maal Ala Aka Oya hr aly. tye
`‘Aue’ Gip Bla Pky Kee’ Cys Ald Tye Naat Raw Ale da Cys Che Sly Cys GEOR NO QBa2J
`saat Glp Gly tle Kaa’ nyse Ale tys Jaa! Ala Kea Aba Gye She Gly cys GEOIN NO: 2583.
`}
`Xas’ Gy Glu Lid Xaal Cys Ala Tyr Fas’ Ala Ale Agal- Cys Thy -@ly ty EGO ce ope }
`Naat Gly ha Ye kaa’ Sys Ala Tuy Kaa’ Bla Ala Cys Kaa’ fae Shy tye
`(SEGNO: S8O5 }
`a Kae’ STY Gy Lie Kaa! Oya Ala Tye Yaa! Kia Abe
`tye The Bea Ghy cys SEAN NOs Broa }
`5 ER
`s Kee Bly @hy Lie Kaw’? Oya Ala Tyr Kaa’ Ala Ala ‘Cys Thr Gly aac cys
`(SEN NG; zo }
`s daat Bly Gly tle kaa‘ Qye Ala ‘ye want Als Ala Cys thr Gly Cys Kast
`(SEQID Wor 26e8 }
`ty Kaa’ By Gle Tie Raa’ Cys Als Tye S14 48a) Ala Cys Thr Glyove
`PSEQIG NEY ee j
`2
`ys Raat Gly Glu rhe Kaa’ Sya Ala Tyr Alu Kaw! Kaa‘ Ala Uys Phe Gly oye SHONO ara y
`Coe Nast Gly ia Ke Xeae’ Cye ala “tye Aly Kaa’ Bis Ran? Cys The Gly ty SCID NO; aro J
`2 Maat Gly Siu Yle Raat Uya Ala Tyr Ala Aaat Aja Cys Xaas Thy Ghy Cys
`(SEONO Vtg )
`o' Saal Gly Glu Tle Raa? Gye Aly Tpr ala Just Ala Cyr thr <aat Giy dye BOS NOS 2703 }
`fe Naat Bly Ga We Raa? Cys Ala Tyr Sie des? Ala Oye The Gly Mex? Cye EONO a7ad |
`Seat Shy Ghn tis Kaa’ Cys Ala Tye ala faa! Aka Cys Thy Gly Oye Rar’ GEONO: 70K }
`Sag’ iy Givi fie Kaat ys Ala Vy Bia Ale Zaat See Yhr Sly ays
`{SRLKO NOD:32768 }
`Seat Aly dha tie Kae’ Oye Ala dyx als Ala Kaa’ kas! cys The Oly cys &JROMO NO B707 )
`Mya Kea Giy Ghy Cle Kaa’ Cys Ale dyr Ala Ala Aha! Gee Keat Tre Gly Cys SEQNC 278 5
`wa Kaa® Bly Gi tle Maal Cys ale Tyr Ale Ale Naw? Cyn The Naa’ Gly Gea
`{SEGINO! 2709 }
`ya Kaa’ Oy Gip tLe Maal Cys Ale tye Ale Bia Mas! Cys The Gly kaat cya
`(ROI MO.246 }
`s Kas? GRY la The Baa! Cys Bla Tyr Alg@ Ala Kea? Cys The Qty Cys Kaa’
`(SEM NO 27 Tt)
`eq Gly She cys Maa? hy Ala We Naat Cya Sla Yyy ata Ala tye Raat Ter Gty cys
`(SEERID NEE BPI}
`Pa Gly hy tys Xa? Uy Sha
`Nea! ya Ala Tys Mla Ala Cys Bau! Raat Thy Gly Ops {SEQ 1X a3 $
`Bee Biy Far Cys Maw? Gly Gla Tis Kaat cys Alayr Als Ala Oye Nea" Phe Kea’ Oly Cys
`{BEOID NOO2744. }
`Ere Oy The Cys Raat why Gla
`2 Sad’ Cys Ala tyr His Ada Oya Kaw’ The Gly. Neat Cys @ERID HO: R218y
`fya iy thr Cys Beat Gip Glu Tle kat cys Ala Pye Ald Ala
`Cys: Sax’ fhe Gly Cys Kaa? EOD NQr 2378
`
`73
`ExOGly ‘Har Oye Rew’? Gly Glu tia Mae" Cys Aha dye Aly Ala Cys Thy Raat Sly Oye
`{BEQID NO: 2777
`b
`weaey Vhr Gye xaa’
`Gly Ghy
`Tie Kaa’ cys Ala TysAla Ale Gye The xa! Kaas Shy Gye
`(SEO NE 2E99 7
`(SOR NOrar7o }
`3 ? ERY. Cys. Nes! Qiy Glu the Kaa’ ove Ata Tye Alea Ala Gye ‘Yhy Mant Gly Cve Kant
`(SEHD NOv gt1 }
`y thr Ga Seg’ Gly. Glu fie kaa Sys Ala tyr Ale ala cys the Gly'RaaY Oye
`(SECHO NO: 2822 }
`thy fia Neat GIG Gis
`Tie Kaa’ Oye Ala TY Ada Bla Cys Thr Gly Raa? Naat Gye
`Phy
`Sea’ Gly Gy
`Kan’ Oye Ala Tyr Ale Ala Cys The Gly Kaa’ Oye Raat (SSI NOL 2723 }
`vie
`“Mag? Gly Glu
`Plea Kaat Ove Ala tye Bla.Ala Qya The Gly Cys Xaat
`{BREND NO: W724 }
`RIG.2
`(sheet$4 of 114}
`
`1400
`
`1400
`
`

`

`WO 2007/101158
`
`PCT/082007/062815
`
`F2f226
`
` iy Th
`
`Rid
`
`awPtGS.FABAGOBAEb &RA4FH444 Shy Cys
`
`Pro Gly ‘fix Cys Xaat oly Glu Mie Kaw? tye Ala Sys ala sla Cys ThE Oly Oye Nat! Aaa GECHONO TZ}
`iy
`Prd Aig hy Qys Seat @ly ha Vie Cyk Kant ala dyn Ale fla Cya Tar Gly oye
`(SBRD ROL eTeS Y
`{ROSHID IME O72?2
`wy Thx Cys deat Why Glu Le. Que Sse’ Xaal Alw Tyr Ma Mix Cys Thr Gly oye
`:
`Yh:
`tye Raa? Oy Gla Xv Cys Kaa’ Rast Kaa’ Sis Yyr Ale Mia Cys Shy Shy Cys
`(SEQ MEK 2788
`;
`i
`:
`2
`y Tae Cys Raat Shy Gky Lic cya Xeat Aaa? Ala Jaat Tyr ale Bla Cys The Gly Ore
`(SFO NO RTS
`CThr Uys Zant Shysik Tle Cyt Kaa’ Rag! Ala tyr Rak? Bla Ate Cye The Gly oes
`(SEOWENG: 273R
`cya Xan! Gay Gla Te OyNew’ Rgav Sis tyr Ala Xeat Ale Gys he Gly cys GEGHINO: 2734
`Pyoyke Dye dasa? Gehy Gla Xda dyes Kaa? Mea! Ala tyro hla Ala Kaa’
`fye. thy Gly fea (SECO NO gide
`Ly Tes Cys
`Raa’ BY Gla Tle Cys kaa’ See Aba Tyr Als. Ala Gye Nast The Gly Ove
`(GID kts 279s
`Ly The nyu
`Raat ity Gin Cie cys Xaa’ Xast Ala tyr Ala Ala Cyw ‘thy daar Gly dey (BEQID he srt}
`}Sae
`ly. Why Oys Kaay Gly Uly dle ya Naa? Raat aka Tyr Ala Ala Qye The Gly Eee’ ya GEO) NO: 2235
`Bre Gly Thr Gys faa’ @ly Glu Die Gye Aaa’ Kaa’ Ala Tyr AlaoAls. Cys Thr Gly Gye Kaas
`(GEGNo.grag}
`Pio Chy ‘hy ye Saxe Ghy Gia Ty Gye Kaw’
`Ae AAW) Tye Bla Ala Sys the Gy oye
`TSEQID HO. TAT
`Fro ohThy ‘lies Cyn Bee? Gy Gu Vie Cys Kaat Ais Kaa’ Kaal Tyr Ala Ala dys The Siy Cye
`(GOW NO Ras
`
`Pro Wy Mar Cya Maw? Shy QIMe cis Mae! Bis Kaa? Dye Bea! Ada Ala Oys Thr Sly Gya
`(EOI No: 2728
`Pro Gly ‘Thy Cy Waa Ody Gia Te Cys dant Ale Raat Tyr Ala Raa’ Ala Cys Thr Gly Gye
`(GemNG 2id0
`pro Ghy Thr Gye East ly Glu Pe Cye Kagel Bis Raa’ Tye Ale ala Asal tye Mir Gly oye (SEQHD NO: Bras
`Bre Shy Var Gye Naw! Gly Gly is cys xaat Ala Xaat Tyr Ala Ale Cys Xnat Thr Ghy Sys
`(GROW NO, 278s |
`
`‘Po SLY The Cyr Kaa’ Sly Slide Cyo Asw Wid. Mes! Tye ala Ala Cya Thr Kast Gly cya (BEQIO NO: 2783 }
`ero iy the ge Kaa’ Oly Glu tle. cya xsal Ala Nes! Dye-Aba Ale Sys The
`Gly tas’ Cys
`(EID Ro. e744 }
`ly Tar Oy
`Sly Gia Tle oye Ras? Ale Naa! Gyr Ala Ala Cys Var Gly cys Kaac (SHOHO: 2745.)
`the
`Sly Gh. Tle Sys Maa’ Ala Tyr Raat Ala Ale Oye Thr Gly tye
`{SRONO: 2748 }
`She
`Gly Gia Tle oye Xaa’ Ala Tyr Neot Raw? ala Ala Gye Dor Gly Oye
`(SRI NORMT
`y othe
`Sly Gin The Cys Kaa’ Bia Tyr Nous ‘Ala Kaa! Ala oye thy Gly Gye
`(SEQ NO. 2748 }
`hx
`Gly Clu. tle dys Kat Ale Tyr Jaa! Ala bis Xee' Cys Tar Gly cye
`(SEOID NOUZ743 }
`“iy
`ey Xaat Ala tyr Maa? Ala Ala Cys Nas! The Bly Cox GSGIO NG ZIG }
`wiy Se
`“hy
`tye Xaat Ala Tyr Baa Ala Ala Cys The faa’ Bly dyy
`(SEGQID NG: 270 3
`eky Gia
`cys Xaat Ala Tyx Bea? Mla Als Cys Thr Gly Yeah cye
`(SROIG NG, 2782 )
`thr Oye .
`7 ty Gia
`Cys Xaat Ala Tyr Had’ Ala Ale cya thr Gly Oya Saw (SEGIDNG: BT?
`‘ey She
`Mr Cys Xe
`yo Thx Gye
`Gye Xaat Ala Tye Ais xaal bla Uys the Gy Cys
`{SEGNK BPG ).
`ety Ge.
`Sly Gu Tle Uys Raa! Ale Tye Ale gaa’ Nav’ Ale Cys The Gy ye ECONO 2755 )
`Ly TRy Uye Mwy Gly Gla Tie Cys Maat Ale Tye Ala Yea! Ale Naot Gye the Sky cya (SRONOCaTSS }.
`Mar Oyo
`aly Win tie Oye Naw? Ala yx Ala Naa’ Ale Cys Baa” ThE Sly Cys
`(SEQHS ROv arr 3
`hr Ups Xd! Gyr Mat Tha apa xag? Ala Dyer Ala Xaa’ Ble Cys Thr xae Sly tye GROWENO:2758}
`FG.
`sheet 88 of 145
`
`}5} }} } }}
`
`)}iéy$\3>
`
`1401
`
`
`
`:
`
`1401
`
`

`

`WO 2007/101158
`
`PCT/US2007/062815
`
`“J LottaihoN
`
`(OEBCHNEE SEfeeMeeeMeaenetenCheOeeeee
`
`$e ¥ aXe%
`¢ ¥eat GlyGla
`
`23g
`we Kad! Ala Tyy Ale faat Ala cys Thr Gly Kaa’ ee (Gtomnoig7sg }
`
`me
`ad
`tza%
`Kaa’ Ala Ty: Ale Naat Aba Oye The oly Cpe Maa! SEN NO: §
`}
`eet Sie hu
`ewpetdeoernd fo.& 2
`“fs aa Bly Giy
`
`Cyan Maat Ala Typ Ale Aba Kae’ (Oys THE @)y Cys
`{SEQ NO: 27a }
`weCoad
`Rar! Gly Gla
`1 Kae? Ala Tyr Ales Ala Kaa’ Mast Gve Phy dig Cyan GROW RO oyae}
`Raad ly aha
`yx Ran! Ala Tyr Ale Ale Kaa! Cys Kaa? he Bly Cys GECID NO: o7e3 }
`ssaea&& 2 %
`Raat Sly Gla
`
`S Kaa’ ALA Tyy Ala Ala Maat Cye Thr Maat Oly Cye PHONeBed
`44
`2 NSA!’ Ghy Ole
`Tle Uys Xaat Ala Yyr
`ala Ala Raa’ Cye The Oty kaa? Gyo’ CREONO: 2768
`
`Nea? Gly Big ile Cys kes! Ala Tyr Ale Ale Raa’ Gyd Thr Gly cya Kae
`(SECHD NOIZE
`Nant Gly Oly Te Cyn Yaa! Ala tyr Ala Ala Cys Maa!
`‘Mir Gly tys
`(SEONO: 28F
`y
`
`Maa’ Ghy Glu Tle Cys Anat Ala Tyr-Als Ale Cys Maa! New! Pe Gly Cye
`BROW WO. 27GB )
`RRR’ Thy @y Xs cow Kaat Abs tyr AIR Ala Oya Mas! Thy Naat Shy cys
`{SEQG NO: PBB
`
`aa’ Oy Giu The cya Raat Ala Tyr-Als Ala Qyw Neal
`the Gly war? cys &SEQUYNO:2P7
`
`Xaa? Oly Gu The tye Kae? Ale cTyr Ala &la Cys Sea’ Thr Sly Gye Xaet
`(SECHO NO: ZTTt
`s Kea? Gly Gla Ile Sys Kaa’ Aka Tyr Ala ala Cys Tor Raat Gly Cys
`PRBOND WCOPPS
`: Raat Gly. Glu Win ys. kaa’ Ala Tyr ala Sia Cys. The Rast Kaa’ oky Gee
`
`(SERIG Nh 22rd
`Raat Gly ih Tle Cys Xast Ala Tye Ada Ale Cys The Ree? Gly okaw’ Gye
`PSECRD NOv 2775
`Maat GIy Gls fig Gye Maat Aka Tye Ba Ale ‘Gye See Ran’? Gly ya feat
`{SEGIO SER2arr
`Nad’ @iy Gia Lhe Gye xual Ala fvy Ale ala Oye Thr Gly xHao cys
`
`(SPQ Ne any
`ly G1y De Cyn daa! ala Spy Als Ale Cys Tay Gly Nast Raat Oye
`(REONO2778
`ve
`wey Gla Yle Gye Neat Mia Tyr ale Ale Cye The Gly Rag? ys Ren?
`
`SRENOE BPTS )
`Pee Oh
`Oly Gin Mle cya Real Ala tye ala Ale Gye The Sly Oye Xan!
`(SEONGNO: SHG }
`Bre Gy
`‘
`‘Gly Gin Tks Cys Xaat Ria Tyr Ala Ala cys Thy Gly Cys Naa’ Kaas
`{SRCRD NOs 2B ED
`Fre ky ‘thr Oye Nast Gly Gla Pin dys Ala Nast Tys Ada Als Gye Der Shy Cys
`“$SRQU NG 2782 4
`geo diy thr Cys Nua Gly Gia Fle Cys
`ala Nas’ Xaat Tyr Ala Ala Cys the Oty Cys
`(SIERQHING: 2783 k
`Pro Cy She Cy Neat Gly Oh Tis Cy Ala Meg! Aga Bax’ Tyr Ada Abs Oye Thr Ghy Gyo
`(SEOIG NORR)
`dro Oly Tur cya Mua My Gly Sle Cys Ale Kaa’ Yoo! Tyr Kaas Gn Ale Oye Thr Gly dys
`Pyro Gky The cys Kee? Gly Glu ele. cys ALA Naw! Neat Tyr Ala Yeah Ale Oya Yar Gly tys. {SEONO: 2788}
`vo Oly Shy Cya kaa! Oly Gia ie Cys Ala Xsat Jeat Tyr Ala Nin Baa’ Oye War Gy oye
`(SEONO: 2786 }
`$9 esa8
`Ala daa! Maat Tye Ala’ Ala Gye Xaat thr Gly Oye
`(SEQIN NO! 2787}
`Deo Gly the Gya Raat aly Shi
`tt 2
`eG
`Pro Gly fhe Cye Keat Gly Gy
`Ala Kad? Raa’ Tyr Ala Ala Cys The Maat Gly oes (SEQIN NO: 2788 }
`Ho
`Aeor)«
`et
`Ala Kas’ deat Tyr Ala Aln Gye The Gly Zaa! cys.
`(SEONO: £760}
`Pre Gly Bee Dys Kea! Gly Gia
`fre. Gly Fix Oye Raw? oly Gn We dys Ala kaa’ Jaa vyy Ald Als Cys Thur Gly Gye Age’
`(BEOID NO: £780 }
`“eo Oy ‘Yhr Cys Bax’ Oty Gu Phe oye Ala Ran’ Tyres! Ala Aly Gyo Thr Glycys
`SEGIG NO! 2784 }
`fre Wy Thy Lys Kast Gy. Glu Tle. cys Ala waa’ Tyr Naa! Kae? Mia Ala Cys Thr Gly Oye (SEQNO2782 3
`FIG.Z
`isheet 36 of114)
`
`
`
`alBA.fetPett4be CY
`
`
`
`
`
`1402
`
`1402
`
`

`

`WO 2007/101158
`
`PCT/US2007/062815
`
`
`
`ya fount
`san?
`wR Raat
`Xaat
`Basa t
`3 Ras?
`FB, See?
`Kaa*
`Zan’
`s Kaa"
`CYS. Lad”
`Mas?
`Swat
`i aA!
`Se MRR?
`& Kea?
`“Raa?
`is ARR?Raa*
`Me:
`ARES
`
`“Aga 3 Kart
`
`Kae‘
`3 Xeat
`mays?
`pa. Saat
`8 xaa?
`Kad
`Kas!
`‘RaaéBass ¢
`Rast
`Nivsgt
`Xeat
`
`
`
`
`
`
`
`Gy ha:
`Bly GLK
`Rly dle
`Oy Gh
`Say asl
`hy 32a
`iy Gia
`BYp Ghar
`F GRR
`Bly Gly
`oS
`y Oy x
`@y Bie
`Gly lu
`aig Ble
`Gly Gly
`oy Gln 22
`Bly Gla
`Riy ha
`hy ech
`oC
`fi
`Big Gla
`aly dhs
`Sly Bis
`Ry ota
`Ry ols
`By Ey
`Ry Coe
`Sy Gls
`
`By vis
`Cy Blu
`My Gla Fr
`aly gin 2
`
` teeoneobPeweenedae
`PEbEBtbetpetbeeferarpewoow
`
`ays
`tys
`Uys
`oye
`ays
`oye
`DY®
`Cys
`cys
`cye
`Cye
`e dye 4
`Re Ovi
`a tys
`vs
`oye
`cys
`& CPS
`ty
`tys:,
`Cys”
`oye
`2 Uy
`2
`thus
`2 OYS
`: tys
`cys
`gyro
`tye
`ys.
`eye
`Sys
`a cys
`tye
`
`aha
`Ala
`RL
`Aba
`
`Naat
`Tye Mae ALA Kaa? Ata Cys The Gly cys
`Kaas
`Mae! -Cye The iy Cys
`Tyr Neat Ria ale
`TAH
`Tek Baal Noy Aka
`cys,
`Raat Thr Gly tye
`tass
`Sys
`Tyr kaa" Ala &la
`The Kaa! Sly cys
`Ruat
`Css
`yt Kae Ala Ada
`TRE Gly aw’ Cys
`Rua’
`Uyr Xas! Ala Als
`Cys
`Tar Qliy Oys. Kaa?
`Xa?
`aya Ada Asx? Als
`eye
`Rhe Sky Cya
`Byex ALE Kaas
`kaa’
`aa’ Als ans Tay Shy cys
`Ala
`Raa!
`‘ter Alu Kaa’
`Seat Oya Lan 1
`sly Uys
`Raa f
`“Cys Ada Kaa’ Dla
`Oye.
`Xga? Yar Gly Oye
`asa!
`
`Spa
`Yr Ble Xaal Als
`The Asal Bly Sys
`Cys
`Baa ,
`Yyy aka Nast Ala
`Tar Sty Keat cyn
`oye
`Kast
`Yykr Ata Saat are
`the Gly Cys xa!
`Kae’
`ove
`yx Als Ala xaat
`Thy Ghy Cys
`Rae?
`Xaat
`Yvr Ala Ala Baa‘
`tya the Gly oye
`Naat
`Evy Bis Ala Nant
`Cys
`Kaa The Gly oye
`taat
`sys
`tys Bla Ala Hast
`She Mest Gy
`Yer Ala Aa Kar’
`2 Naa!
`nye
`whr Ghy Kaa‘ 0ys
`Sag?
`Yyn Ala Ala Kase
`‘thy Ghy lye Raa?
`theaXeav
`f MRE!
`Tyy ala Sls Cye
`the Ghy cya
`Xay?
`tyy ala Als Spa Kaa!
`Age? Par sip Cys
`Saat
`Dye Ala Ala Cys Xa!
`Thy Kaa’ Sly Qa
`Xad!
`Thy ky Neal yx
`tyr Ais ala Cy Rs’
`A Kea‘
`tye
`The Gly Cys Nas!
`Ale ala Nys Raa’
`The
`“ae!
`Kaa’ Sip Cys
`tyr Ale Ale Cys
`ae 6
`Kaa’ haa? Ghy Cys
`Tyx Ala Ala Oye Thr
`Kae’
`Tyr Ale Ale oye The Kse’ Gly Kaa’ Cys
`Kaa!
`Tye Alx ale Ops Mik Kea! Gly Cys Yaa!
`:
`ini
`eat
`Oya
`Tyr-Aly ala Oya The
`Kar?
`Kaal Cys
`Cy Naat
`tyxy Ala Ala Sys The
`G
`Kaa’
`Gly Nast
`Tye Als aka tgs ‘Thr
`Sys Awa!
`Kaa!
`Tyr ARS Aka Ove Phy
`Gly cps Kaa’
`; Kael
`tyr ale Bla Cys Yar
`Gly Cys Raat Neat
`‘yr Rant Bla Aba Cye Thr
`Shy cya
`_ FIG.
`{sheet 57 of 1148)
`
`{SEQNK 27BS }
`(BRU RO: BPM)
`{SEQUINO: 2798 }
`(EQN EO. 2706 }
`SHOW NOX 27ST )
`ISEQIG NO: 278s )
`IhEOHO NO: BGO }
`{SEH NO: Bean |.
`{SEIN Nee SHG}
`(SEQRG: 2s)
`(SOK NO: 2505 }
`ISI NO: aRas |}
`{SENGs 2805 }
`EOI HO: 2800 }
`ISEQHS MO: A807 }
`{SEGRE NO: SOS }
`FAD NO sed}
`{SRQUD Nth 2BIG Y
`{SEQNOs 2817}
`SEONOL ABR }
`{SECNO MO: 2813 }-
`}
`(SEO NO2818
`{SEONOs e848 }
`(SEQ. NG BBB
`(SEQUIN WO BRET
`(GERND 0c 2818
`{EQID NOC 2819
`(SEQID NO; 2826
`{SEOID NO: eet
`{SEQ NO: 2822
`{SEQNO: 2823 |
`(SHON NO: 2B24
`POEQHI NO: 2625
`
`
`
`ISECHD Non 2626TeeeerecitNetcapeneeteeee
`
`1403
`
`1403
`
`

`

`WO 2007/101158
`
`PCT/US2007/062815
`
`*%
`
`Res
`
` bebe
`omeiowedegaee
`aGmSs
`o4 29asseod
`
`one
`ao s
`
`fineat&
`
`i Raa’Xaal
`yO. Ba €
`tee XR
`Ryn
`Kan
`2 Oye
`& Maat
`&. Oye
`
`Ova
`
`Cys
`oye
`ays
`e-tys
`Ove
`ye,
`eys
`Uys
`: tys
`Lays
`oys.
`L Sy"
`aya 2
`2 Dye
`B fyo
`
`Ala
`ala
`AlaYAR
`aha
`ALR
`Als
`Aa
`ala
`ALR
`Ala
`Ala
`ala
`Ala
`‘Ala
`Axa
`
`Xena t
`
`Raa f
`Zant
`Sea €
`Baa
`Raat
`‘Zag?
`Raa?
`Naa!
`Xara’
`xaa’
`waa
`Zant
`Saat
`Raat
`Raat
`Y Raat
`taal
`saat
`Baas
`i Kast
`Ateeys Rear
`xan?
`Y Raat
`Raa’
`Maat
`Kae’
`Kaa!
`Xas'
`Ras!
`xna!
`Yaa?
`Maa!
`Raa’
`xan!
`
`Tyr
`aye
`tye
`Nyx
`tyr
`‘tyr
`tyr
`tyr:
`tyr
`tye
`ayer
`wer
`aye
`tyr
`
`aye
`tyr
`tyre
`tye
`ye
`
`¥
`Als Sa ye Thr Gly oye
`Maat Naa! Ale Adu Gye Tax Sly Cys
`Rea? Als Kaw’ Ala Oye the ely oye
`ABRT ARG Al Kaat Cya Thy Sly Oye
`ABR? R1S Ala Oye kaa The Sly Cys
`%ea’ Ale Ale Cye Te Ban’ ahy ys
`“Xaat ale Bia Oya War Gly Kaa cyvn
`Kaa’ Bla Bis Cys Thr My fyn Kaas
`Abe
`Seat Ala Cye
`Ror Cy bys
`Ala
`Han! Raat Ala Creve Boy
`Als
`ya
`Raa ALR KN Oye The ely
`Ka
`Rea! RIB Coe
`Kae’ The Shy cee
`Ais
`Xes! Aba tye
`TRE Beal Bly ¢
`KTR
`Xaal pla Cys
`The Gly Krat cys
`Xax’ pla oye
`Thx Gly Cys. Xeat
`Ala Kea’ Cyn
`Mr gly tye
`|
`Ala Keat
`Raa nyse The Gly oye
`Ale Saat oys
`Mast Yar Gy oy
`3s Kaa’ Cys
`The Baal Gy ove
`Ale Yaat
`tyes
`Yhe Gly Xaal ys
`Ala Yas’ Cpr
`the Gly tye Ses:
`Ala Sys Saw?
`thr Gly cys
`Ala Ove Xea?
`Kaa’ Thr Sly dye
`Ala Cys Xaa!
`Thr Naat Gly oye
`Bla Cys Kar’
`thr Gly Kaa’ Sys
`Thy Sly Gya Yast
`Als Uys fae!
`ATs: Cys
`Thy Xaat hv cys
`Sha Cyn The X
`kRa Ras! Gy Sys
`‘Bla Dys
`Tay Sea’ Gly deal Oye
`Thr Xaa! Civ Ove Xa’
`ala Dyn
`The Gly Maal oys
`Ala Cyd
`Ala Oya
`The Gly Kaa’ Rast cue
`Ala Cyk
`‘Thy Giy Xaet Ova an?
`Ala ys
`“Whe Gly. ten, Kaa?
`‘FIG. 2
`‘(Shoot 58of 214)
`
`is
`Ras
`Als
`Ale
`le
`‘Ala
`Aza
`Ale
`bia.
`ala
`Ala
`Ada,
`Ala
`Aka
`Ale.
`Ale
`Ala
`Ale
`Ala
`Ala
`
`
`
`TeeleteanMaalSepttnetetStMOedSottneeetet
`
`{SECID- NOs ART
`ISEGID RO: ge2R
`(SEQINRO: ez9
`ISEQIDNor BEAD
`(SHQID NO: S834
`{SEQNO: £892
`(SEQNOE Rese
`(REQIO NO: 264.
`{SEQ NO: 2888
`(SEOID NO: vase
`(SRGID Ney BB9T
`SEQ NO: NER8
`PSEQHI NC2825
`iSECND NOs BedO
`AShOIG NG geal
`(SEONO: Bade.
`RSEQIE NO: BBS|
`
`TREOHO NO! 2844.)
`{SECHO Noe 2845 }
`(GECKO NO: Sasg 3
`(SHONO: Baay }
`(BEQUS NG 2888}
`SEG NO: 2848 }
`(SROIG NOE 2880 4
`TEROQUE NO: gad |
`ISEQID NO: 2a}
`
`(SEOID NO: 2853.3
`(SER NO: 3884}
`{SEQUE NO: 2B55 }
`{SEQNO: 2858}
`(SEQIS NO.28873
`{BBQNO? 2B88 }
`(SEQ NG: 2899 }
`{SEQID NO: 2e80 }
`
`oye
`e oye
`Le Gye
`cys 3
`Cyn
`cya
`Cys
`oye
`oye
`tye
`aya
`
`Keat
`
`Raat
`H Xag?
`Sry Cys Naat
`
`
`
`
`
`
`
`
`
`
`
`1404
`
`

`

`WO 2007/101158
`
`PCT/US2007/062815
`
`76/226
`
` Eye
`
`Tey
`Epes
`
`ia
`Cys
`Ogee
`oyr
`ys”
`ys. :
`cys
`ayn
`Se
`dys
`Ses
`Cys
`Cyra
`oye
`2 Uys
`eye
`5 Cys
`
`
`
`1 Raa? aly 6
`
`Rast
`s Hwa
`“ge SRa'
`Rae!
`Yi Bag?
`ye. Kaat
`Raat
`S. Kaas
`2 Kaa?
`Kaa’
`S Kae?
`Ra 6
`Syn. Baa!
`we Xai?
`t Naw?