Uwe Christians, MD, PhD
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`Professor, Anesthesiology
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`ungwg1s: EngllUI
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`aep.rtmeot M lhf'SiololY
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`Publications
`• Hunt« SI(, Freedman R. Law�. Chnstiaos u. HOizman JBW, ,ohnson z. HOffman MC. Mlt«n.al conteO!.tffOfds and
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`heart rate, vanabl1,ty. Neurortport 2021 Oct 6:32{14):1170-1174. PubMed
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`dtpression duringges1a1ion a,'\d deuused fe-tAl
`PMIO: 3428444S
`• Mayne G. De EUoois E, Dabelea
`o, ChristiaM, U. �1 Mid valid.1tion of ari LC-MS/MS
`assa)' for rht quantific.\tion of
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`alloprtgnanolotll! and JtS progMt«one-denved 1S01Mrs, prK1JrSO($. ar.cl cort1sollcorusone
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`1n prtgn,ncy. An.a l Btoan.11
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`Chtm. 2021 �:413(21 );5427-5438. PubMed PMIO: 34279681
`SH, uw Mpungu E, Zl"IS� wyrwaA. NOONl1 I(, Chm.uansu. Nalamuh MC. M<Carthy L D'Nessandl"OA,
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`• Huntff SK. HOffman
`:886-887. PubMed PMICt
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`BoU. 2021 Jut 8;47(4)�-frtedmao R. Target,ng Trearments to HeMth DispantiH . Schizophr
`3""°629
`• Ch.want A. ,lourdil Jf. Jouw T, Christians U, Fonrose X. Stankt-tabesque F . A $1mplt and easy-to-perform liq uid
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`and its metaboll1M 1n human v.hOlt blood.
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`chfomatogr.aphymass spKtrOmeuy method for the quanuficanon oftacrobmus
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`Appl1Car.on to the de1eminc\1 ion of metmolic ratios
`in k � rran�plaru: p,31lenl$.
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`J ChrQmclrc:,gr B Anal'yt Te<hnol Biomtd
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`Life sc,. 2021 Apr 8;1173: 122698. (Epub ahe.td ol pnnt) PuNM-d PM!O: 338 78532
`of 14 Kl.awltttr J. Anatysis J.Ja(ksoo M. Fren i F, Shilllfllbutl R. HulCtmon K. Bictwe!! LC. (hnS.!IMIS u,
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`• Sffllp,oC. Klawitter
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`endoc>nMblnoeds .:1nd endocann>blnoid congeners in hUmMI plasm.a USJng colUIM S'Mtchlng hlgl\-perfonnance
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`armospheric preuure chemic,1, I ionizarion
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`liquid chromatography.mas•; spe,:rromerry. Anal Bioanal Chem. 2021
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`May:413(12):3381,3392. PubMed PMIO: 33817753
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`• B.li6p MM. Klawiner J, Chnsrians u. Hopp K. Choodlol M, Girome,-av , Cadnap,aph:)rn(hal
`MA. Klawitter J . MetabolK profiling
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`in children and young adults With autosomal dOIT'INl nt potycyl;uc kidney diseas.e. sc, Rep. 2021 Mar 23: 1 1 ( I itJ629. P\JbMtd
`PMID: 33758231
`• 5empioC , Almar.u-Quinones N,Ja<kson M, znaow. wangGS. LJu Y. LethtyM, Knupp K. Klawitte<J. Chnsuans
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`u. KJ.awme< J .
`Simultaneous Quant,f1Carion
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`of 17 C.tnoabinOids bY LC·MS-MS in Human Plasma.J Anal Tollkol. 2021 Mar 23 jEpub Mlead
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`Of pnn!J PubMed PM!O; 33754154
`• Sempio C. 8al'.Mltll LC. Hutchison K. Ht.1tst1\ MA. Klawitter 1 Chrisrians U. Henthorn TIC Using Population Pharm,.JcOl<:i � K
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`MOdelmg to Estimate (Jq)osure to ?'9 Tw.JhydrocanMbmol 1n .an �rv.anooal 5tucfy of Cannabis 5moken. m Colof�.
`�Drug�'-2021 Aug 1;43(4);536-545.
`Pub Med PMIO: 3)656464
`• HuntN" 51(, HOftman MC. McC.:lrthy L 0-AlessandroA. Wyrwa A. Noonan K. Chmtia!M u. Nalamuli,Mpungu E, Zttsel
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`SH, LaW
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`� �ntol (;.e\tational Age at Birth.,&J. fretdman ll Black American Mat�nal Prenar� Cholint'. Offspring
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`Pr�sposmon 10 Mffilal
`IHnMs. SChlrophr Bun. 2021 Jul 8;47(4):896-905. PubMed PMID: 33184653
`LC, BK.JclnikOj,Jameson CJ. Vogel SA, S.Cott (. Kaizer A.Christians u, Burger E. Patel V, IOe<k
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`AM, Dingmann
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`• CL;lvljo CF, Oliva
`GtndeM TOlltcok>gy screening "Testmg 1n Pa11ents UndergOlng
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`Sp1M S.JrgftY-"' Prospe«M' �auoo.11 Ptlol S1udy. The-r
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`Drug Mor-Mt . 2021 F� 1;43(1t,36-138. PubMed PMIO: 33181620
`Oeprewon m • Freedman R. Hunter SK. NooNn K. Wyrwa A. CtmstJMtS U. Uw ,&J. Hoffman MC. Maternal Prenatal
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`Priegnanc
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`aod Cortisol Biol With C•reactrve Prorelfl 1es With Ftrnale and Malt FerustS and �eloptnen1at Assoc�uions
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`Psythlatry Cogn Neurosc1 Nwroimaging. 2021 Mar,6(3�10-320. Pub Med PMIO: 33060035
`• Ye H, Mlnhajuc:klin M, Krug A. Pei s. Chw CH. Cutp.H�I R. Ponder J. Ort DIOOis r. 5chniedewind 8
`. �,l ML ln&tN,t �
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`Uniquely M1m,ern�r�t U, Gnme-s HL.. O'Aleswrwro A.Jordan CT. The Hepatic
`Si evens 8M, P� 0A. Chnsnans
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`Prote-cts Leukem.t Cell$ thr'()l.lgt\ ln(lu(tion ot Growth and Survlv.tl Partiwm � I.lied by llPG. Oncer 0,S(OV.
`2021
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`Feb;l 1{2):500-Sl9 . PubMed PMID: 33028621
`u. Kl,w.iitter j Delt<tlOl'I or cannab11·101<1S by LC-MS-MS
`(, w,rno<e E, P.t!mer C. 81)n1k M, Heflthom
`• Sempio
`Tl<. (hn$.!1¥\S
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`Milk.JANI TolOCol 2021 Aug 14;45(7):686-692. Put•Med PMIO: 33002141
`and WSA1n Breast
`Response • MuunoT. McPtia,I BT, Kamatk.lr5. Wexelblatt s. Ward LC"'1stians u. Nonbi HT, \/inksM. PhySIOlog.( lndt<tct
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`fOf Neonatal Opioid W 1thdf.l� �rome.
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`1n Newborns Treated
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`Modeling to DHcnbe 81JP("tnorphme f>Mrmacodynamics
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`Cltn Phar�()l(ll'lf!t. 2021 FW:60(2):249-259. Pl)bMed PMID; 32939690
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`• Van Hoogdaltm MW,}Ohnson TN, M(Phal l 8T, Kamatkar s. WeKe!blan i>L.. WMd
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`LP. Chnstians u, Akmbl HT, \finks M MtZUno
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`T. Ph)'SIOIOgieally-baSed ph�Oklf'lt(I( modeling 10 ,nvest�re the errtct ot � turation on buprenorph1ne
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`pilarmacoklnetKS in newborns With neonatal optOtd v.ithdrawal syndrc,me. Clin Phannacol Ther.
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`• Peters r. Ma(Nair L Mostsova t ChrisMns U. � c, toav.,ner J. Land: MH. wart MA Turcont C. Sonn-M1lttr MO.
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`Pharmacokmeuc.s ol cannab1Chromene 1n a medKal cannabis product also conta1rnng ca�dlol and ?'9
`. Eur J Chn Phatm.JCOI
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`rerr-,hy(lf"oc.annal>lnot" j)IIOf sructy
`• Ca-wthon CV. Cooper I(, Huen c. UOl'e< A. Villar-Matamoros E. Stokts L Chnst1,1ns u. 5chultr M, Yaz<larn SK. �Chr11aJ
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`'Xel fQf Local Or\Jg Delivery: A Pilot 51\Kty. l;>t\a rlN(aitKals (8,tstl). 2020 Nov 28;13(12}. P\lbMed
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`�wganon ot L1qUIC:I P;,cllti
`PMID: 33260517
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`• Humtr Sk.. Hotfm-,n MC. McCarrhy L O'A/ttsanclw"OA. W'jfwaA. Noot\,ll IC. Christian su. Nakimuh•Mpun,u E, Zeisel SH. WW
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`�, Frff<lmao ll Black AlrM"rK.itl Mater!Wl Prenatal Choltr.e, Offspong (;.estatJOn.al "1,e al Barlh. and �tal
`10 Merilal lHness. Schz(lphr Bi.Ill. 2020 NQY
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`13 (Ep!.11) aho�ild OI pnn1J Put)Mt(I PMIO: 33184653
`Prtd1sposrti0n
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`C. Kaizer A.Christi.ans U, Burger
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`E , Patti V, Kle<k Q, Vogtl SA, SCott 81<.,J,anik Oj,Jarnnon LC.
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`• Cl.tv!JOCF, Oliva A M , Dingmann
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`Gin.:leM TO�IC(lk)gy SCrttn11"1g Tes11ng In PAflt'flts Undtfgoing
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`Spine SJfgtry. A ProsptCIIYt Obstrvauonai Pl!OI'. Study. Thtr
`Drug Mol�t. 2020 Nov9.{£pub ahead ofprintJ PubMed PM10; 33181620
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`• Frffdman R. Hunter SK. Noon¥! K. Wyrwa A. Chnsrians u. Law ,&J. HOflman
`M C . Wtefnal Prenatal DeprttSIOl'l In
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`Prfgl'\llnC!d With Fef'Yl4141 and M41t Fetuses and Devt-lopmtntoliAUOC.�)llOl'IS With C ft.X.l!Ve Protffl"I and Coni:IOI. 8IOt
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`Psy(hlatry Cogn Neurosc1 Ntlll'Oll'na&lfll. 2020 Aug 13. (Epub ahe.td ot print) PubMed PMlO: 33060035
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`• Ye H, M1nhaiudd.n M. Kfu8A. Pei s , OIOU CH, Culp-Hill II:, POf)der
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`J , DeUIOOIS £. Schniedewind B , Amlly.s ML.. lnguv.11 A.
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`Stew<is BM.� DA. CMsrians u. Gonme-s HL O'A1essan0ro A..IOf"dan CT. The htpatK nvcroe�ronmen, uniquely
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`Olscov. 2020 OCI 7. medl.llled by UPG. Cancer protecu ltuk�n,,1 ctlls thlough induction of growth and SUMY.111 p,attr,.,.ays
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`(Epub ahe.t<101 pr,ntJ PubMed PMIO: 33026621
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`TK. Chr!Sl.l--.s U , Kl,)Witter • 5emp,o C. W'J'!flOr� E , Pa!mt" r C. Bunrk M. Henthorn
`J . Oetect,on of C«'ll"l.llb.noM:k by LC MS-MS
`and ELISA 1n Bteast
`Milk..) Anal TOlllCol.
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`2020 Qcr 2. [[pub ahead or pnrlt) Pul)� PMlO: 33002141
`HT, V1nb AA Physiologic: l!'drtcl 11:esporist
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`• Mll:uoo T, McPh.a1I BT, Kam.!ltkar s. Wtx�bl-alt s , Ward L Chr1St1.ms u, llloob!
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`Tr t,1ted !Of Neonatal � ling ro �• be Buprenorphtne Ph.iirm.)(odynanvcs in NewbOfns OpiolCI W 1tl'ldt.:1w."11 Synclromt
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`Cl,n Ph.irn\M:obnet. 2020 Stp 1 7 . (Epub ahead of prrnt) PubMed PMID: 32939690
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`dOSlnj :md ptl,lrmacoklrltll(S for • F� A.. VMI Meurs KP, Drowr OR. KL'.IIYltt� J. Chr'kti.ms u. ChO(k VY TnfOptiylllne
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`rfflal l)l'Ol:tcllon ,n nf:Onatn Wllh hypollK 1$(.htl'nl( el'K� IOJ).ll thy uodergomg lheraptull( hypo<henriia. Pedt..!il r 11:ts. 2020
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`Dtc88(6J 871-877. Pub\1ecl PMIO: 31919393
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`• Chr1�l1.ansU. 11:oge.-J�hffe MD. F<:P, FMPSObitu.ary. Ther DNg MOnit. ,l020Aug 10. \Epubahebdofprrnt) PIWMed PMIO:
`.ll7'l6388
`• Sd'lrue<lew!t'd B. � EJ, Chn�uans U. Long T «fl'I Per forlYla!'ICe of Lab<H" a!OfY·Oeveloped L,qU!d Chfom.Jtogr •phy 1 andem
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`MaSs Spe<:tromerry Tesrs ancl a Food .1nd orua Adrninis1rat
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`100-Appr0Vi'd lf1'lll"IUf"IO.l fOf the lhtf.lpeutlC
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`On.I&
`MOn1t0rrngofEVffl'.11 111l!J$. Th« Or'4MMIL 2020JV0:42(3);421-426. PubMed PMIO: 32427781
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`• jtllifre It ChtiSl1¥1S u. The� Dire-ct-Aet1nj Or.'11 Anl1CO,)JUl,:mt$ Nttd to be MOfUIO(edl_ TTlef Drug Monlt 2020
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`Jun;42(3):3S7,359. PubMed PMIO: 32427780
`Folke SfOCl','ISI. Ther Drug Mon1t.
`• Christians u. �fho(O TK. W.)lson PD. OOlerieh M, Eliasson f . In Men'lll0.1m: Proressor
`2020Apt 15. (Epub ahud of pnnlJ PubMed PMIO: 32304489
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`• � E. Erwin M, C.:l'Mhon Col. SChattC. Fedol" N. R.l)'I T, WitsonO . ChnS'tldns U, Rt>g1$.!e<TC. Gea,yRLSolulJ.
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`Y,UdMli SJ( Pre­
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`Co.Jted Balloo ns. Mgie<.uln. 2020 M.sr 31 ;'25(7). Pub� PMlO:
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`Clmiul lnw,strgalKlo of K� aloi.e ,n an ExC1p1ftll of Drug
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`Faculty Profile | School of Medicine | University of Colorado Denver
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`https://som.ucdenver.edu/Profiles/Faculty/Profile/4832
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`1/5
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`Bausch Health Ireland Exhibit 2005, Page 1 of 5
`Mylan v. Bausch Health Ireland - IPR2022-01105
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`• Wang GS.. h.lrn, UW"-'°'1wltt!fJ. �C. Ctk4pm4n K. Knupp K. Wffl'!pe: Mt-. BOfg�t L cr,nstiaos u. � rdJ H,ard K.
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`BajaJ L. 0.�lion of Or.11 C.x"ln.lbtdtOI-Aich Cilflf'k\l'.Ms EX1r¥ts WI Children wnh Epdt'f>SY. Cho Ph.Vm.1Co
`kinet. 2020
`Aug:S9(8):100S·101i. Pu� PMID: 32048179
`• Sempto C. H�ll$ MA. M1kUlkh- G1lbertson SK, KLwoitter J. Chrisrldf"IS u, Henthorn TK. Population pharmacok11'W'!l1( modeling
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`ol plasma '9 1,1,ahydrocann.,bmol Mid an ac:tN, .tnd 11'\aCIM' �abolil" foMowing conv� !>ITIOl<.N'.I c.Jnnabts
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`�mIn,str.111on. Br J Chn Pharm.l<OI. 2020 Mar':86(3).:611-619. PubMf!(I PMIO: 31747464
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`• Stdv,11 T. H.wtmann M. O..W.,, 1 8. Kl<'!witttt J. Klawitte'f J. ChnstJans U. TNTIS1rol1mus �abolic pathways revi5"1t�
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`Xtnot:Mo{l(,1. 2020 JIJI\S0(6);640-6S3. PubM('(I PMIO:-31596164
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`• Davar, B, KotKha N. ClaviJO CF-. Thom.ts]. Rzasa Lyon R. Gabnbn JL Christians U, Sttnpio C. A Sttlsit� LC MS/MS Assay (Of
`rht Qu.lntifK.1111:,n 01 �,� .wld ,rs Mc1->bol,1es in Drie-d Blood Spots; Com� With Plasma. Tl'!ff Drug Mol'llt. l020
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`ftob;42(1rl 18· 128. PubMt!d PMID: 31318842
`• W.ing GS. BoorM OWA. KI.Wlitter J. semp.o c. c� K. Knupp K. Wernpf' MF. Borg� L Chnstians
`U. HNr(I K. ea,.:ii L.
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`Ot�11on or Oral °"lta 9 ,�rahydroca!'W'lhbmol {THQ m chlldrttl rK,IVlng cann.ati.s ,Ktracts fof t1)ft�y. Chn TOKICol
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`(Phil,\). 2020 Feb; 58(.2): 1.24-1 .28. Pul)Mtd PMlD: 3111 1749
`• NI appro.,c;h to btomark"'° dtSC� or ctir'lnabrs uSt-utJl1t1ng prot,011.c, metabolomic. Mid hpidomc ,tnalysn.. C,,rin
`C;Nlf'lJbR�2020
`drug: mo1111or1ng of
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`• AA>t-w- 0!1 S.. Bugg-; V 5d�nd 8. Sobha111 K. Chnst1ans U. Kdty KA. Tl1"fdj)Nl1C
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`mmunosuppressams. In: fOXl(ology C.lStS lor The Clln!Gal <ll'ld ForensK l..lbofJtOfy Kctha H, Garg u le<IS) Elsevier AC.l(k-m.c
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`Pr� San (Mgot2020). pp. 317 332
`• Hinckley JO, 5.)1).1 L. R.lymond K. B.wtels K. J(� tter J. ChrtSll,l(IS u, Hopi er C. An ApprOach to B+omi)rke r 0tsc0'v(>,Y 01
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`Cann.sbrs � Ut1l1Zlllg Prot�. � bolomlC. llf){j LIJ)l(k:>ft'Mc Analysg Cann.tbis CanMbino!d RIM. 2020Jun 19. [Epob
`Jht.-W:S or pr'int] Pul)Me,d PMID; 3.3998853
`A \lillar-M.J t.mlOl"OS E, Siok� L Chn">baOS u. SchulN M. Yd2d.tll! SK. Pr� Chnic,1!
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`• C<Mthon rY, c� K. HUNt (. Uor"
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`lnYestig,ltlOll ol l)quid P�lit.:lJCel ror local Onig OelM?,y: A Pilot $1:IJCti. Pharm.lCMIC� (S.ls.?I) . .2020 Nc;:,.i 28;13(12) �
`PMIO 33260517
`• fryrl"'M)yer A. v.vi Mwr-s KP, Drowr DR. 1(1,lWlttef J. ChnStl¥1S U, ChO(k w Theophyllt� d0$ttlg .wld J)Nrm.lCObllf!ftCS lor
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`Wllh hypoKIC·tSChfflllc: tne,phalopathy u1,d,@, 1go.ng therdp@ullC hypotherrn,,a_ � ,ittr R� 2020
`rffl<JI prOlKUOO 11'1 neonat�
`Dec;88(6)·SJ1-8n. PubMe<I PMtO: 32919393
`LC MS/MS T�s ancl an FDA
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`• SC�ncl S. Mt-YN EJ, Chns1.ans U. Long term Petformanc� of L.tboratory
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`Jppfov«I lmmuno.JS-5.)y lor lht
`Thef,)peu!I( Dl"ug Mon1t0flng or Everot1mus. Ttier Ol\lg MOrl,I. 2019 OC:t 7. {Epul) ,)ht.)CI OI'
`pnrttJ PubM� PMID: 315-96754
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`X�Ka. 20190ct 9;:1-30. (Epubh.Jd orpnnlj PubMt-<:I PMID: 31596164
`• Weinberg A. Htl()Y, K.l(.;aflci( 0, P.lfCI K. WslttS DH, W.va 0, Holt(llJn RM. K� rter I, ChnStkll'IS u. Bn cl Report ; MJf'kersol
`Pr"1'rm De-lrmy If! womt-n Liviog With HIV: RriatlOf'"ISNp With PrOlf!aSt" lnhlbm:irs and Vitamin 0. J Acqu,r
`Sponk\neous
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`lmml.lfle: Oell(Syndr 2019()(.T 1;82(2):181-1 87. PubMe<I PMID: 31513074
`• 0dvar1 8, Kol Kha N. aaviJO CF. Thom.ts". Rzasa Lyon R. Gahnk,nJL Ch11S11ans u. � C . A SENSITIVE LC MS/MS ASSAY
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`FOR THE QUANTIFICATION OF METHADONE ANO ITS META80LITES IN DRIED BLOOD SPOTS.: COMPARISON WITH Pl.ASMA.
`Tht-r Drug Mor'l1L 2019Jul 1S. jEpubn.adof P,IOI] PubMt"d f:>MID: 31318842
`J. PtMJOgtOOA K1r1<p.11ndi: 8, Roda G, l(Ole<fl.l NC
`, Thurm.:inJM, ChfiSO.lns U Cy(loptnhn D knockout
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`• Klawin:e, J. KlaWl!lef
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`PfOlN:l5 ti"� k� ag<11MI cyd05'lOl"IO A-mduCN'.I OKldal� Slr'5s. Arnj Ph)'51()1 Rffl.J I Ph')"IK)I. 2019 5'p
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`1;317(3):F6U-f694. Pl)l)Med PMIO: 31188033
`U. �rd K. 8.tjltj L. • W<1ng GS. Bourn, DWA Klawitt!H J, Sttnpo C . Chapman K. Knupp K. WtfflPI! MF. &:,r�t L Chnstaans
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`Dtsposmoo or oroll Clclt.l-9 u:rrahy(lroc..)M.lbi� {THC) in chil<Sren rt-cei\llng C,ll'll\,lblS elO'r.lCls lo, epilepsy. Chn TOJCICol
`(PMa) 2019May- 21;:l 5 (Epub� adofpr1ntJPubMN'.I PMIO: 31111749
`• Brunt!! M. van Gel(le( T , k:oorgA. HaulroidV, Hessehnk DA. t..mgm,m l. Lcm.lrtreF, M.:irqvet P, sege, C, Sh1pk0Vd M. Vinks
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`A. wallm.acq P. W"1and E. WOIMa«:IJB. Bar"n MJ. Budde, K. Cobn H. Dt"!f� MT. Elt-ns LjOhnson-D&ils KL Kunitki PK.
`M.xPhee I, � s. M.:ithtW 8S. M�l'I 0, Mizuno
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`R, T, Moes OAR. Mon(t'l,)u(I c. Noceu o. PJW1nsk1 T, Pturd N, V,ln Scf'l.111,;
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`'5om!-t1'rtt (. V"ht> NT.� WintN" 8, Chn'Stl<ll'\S U, BNg.in S . Th"'"�U tlC One Mon1tor.r« ofTacrohmus-PNSOn"h™
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`Thtr.::apy. 5e(Ofl(I Con�sus Rep011. The, DrugMOn1t 2019jun;41(3):.261 -J07. ?ubMed PMIO 31045868
`J. S..oilh D. R"f)lm-JE ()epr'5.S('d
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`• Golomb 8A, � 1kHJ. ChriSllanS u. R1tchi"J. WIison P, E""-111$N. Kl..twt tt,r j. Klawit1'1"
`
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`Faculty Profile | School of Medicine | University of Colorado Denver
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`https://som.ucdenver.edu/Profiles/Faculty/Profile/4832
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`Bausch Health Ireland Exhibit 2005, Page 2 of 5
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`3/5
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`Bausch Health Ireland Exhibit 2005, Page 3 of 5
`Mylan v. Bausch Health Ireland - IPR2022-01105
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