throbber

`
`21ST EDITION
`
`Remington
`
`The Science and Practice
`of Pharmacy
`
`
`
`
`AN LIPPINCOTT WILLIAMS & WILKINS
`
`A Wolters Kluwer Company
`Philadelphia « Baltimore « New York « London
`Buenos Aires « Hong Kong « Sydney « Tokyo
`
`MYLAN - EXHIBIT 1006 - Part 1 of 2
`
`

`

`
`
`Editor: David Troy
`Managing Editor: Matthew J. Hauber
`
`Lippincott Williams & Wilkins
`
`351 West Camden Street
`Baltimore, Maryland 21201-2436 USA
`
`227 East Washington Square
`Philadelphia, PA 19106
`
`All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form or by any means,
`including photocopying, or utilized by any information storage and retrieval system without written permission from the copy-
`right owner.
`
`The publisher is not responsible (as a matter of product liability, negligence or otherwise) for any injury resulting from any
`material contained herein. This publication contains information relating to general principles of medical care which should not
`be construed as specific instructions for individual patients. Manufacturer’s product information and package inserts should be
`reviewed for current information, including contraindications, dosages and precautions.
`
`Printed in the United States of America
`
`Entered according to Act of Congress, in the year 1885 by Joseph P Remington, in the Office of the Librarian of Congress, at
`Washington DC
`
`Copyright 1889, 1894, 1905, 1907, 1917, by Joseph P Remington
`
`Copyright 1926, 1936, by the Joseph P Remington Estate
`
`Copyright 1948, 1951, by the Philadelphia College of Pharmacy and Science
`
`Copyright 1956, 1960, 1965, 1970, 1975, 1980, 1985, 1990, 1995, by the Philadelphia College of Pharmacy and Science
`
`Copyright 2000, 2005, by the University of the Sciences in Philadelphia
`
`All Rights Reserved
`Library of Congress Catalog Card Information is available
`ISBN 0-683-306472
`
`
`
`
`The publishers have made every effort to trace the copyright holders for borrowed material. If they have inadvertently overlooked
`any, they will be pleased to make the necessary arrangements at the first opportunity.
`
`The use of structural formulas from USAN and the USP Dictionary of Drug Names is by permission of The USP Convention. The
`Convention is not responsible for any inaccuracy contained herein.
`
`Notice—This text is not intended to represent, nor shall it be interpreted to be, the equivalent of or a substitute for the official
`United States Pharmacopeia (USP) and/or the National Formulary (NF). In the event of any difference or discrepancy between the
`current official USP or NF standards of strength, quality, purity, packaging and labeling for drugs and representations of them
`herein, the context and effect of the official compendia shall prevail.
`
`To purchase additional copies of this book call our customer service department at (800) 638-3030 or fax orders to (301)
`824-7390. International customers should call (301) 714-2324.
`
`02 03 04
`2345678910
`
`

`

`
`
`A treatise on the theory
`.
`.
`Remington: The Science and Practice of Pharmacy .
`and practice of the pharmaceutical sciences, with essential
`information about pharmaceutical and medicinal agents, also, a
`guide to the professional responsibilities of the pharmacist as the
`drug information specialist of the health team .
`.
`. A textbook and
`reference work for pharmacists, physicians, and other practitioners of
`the pharmaceutical and medical sciences.
`
`EDITORIAL BOARD
`
`Paul Beringer
`
`Pardeep K. Gupta
`
`Ara DerMarderosian
`
`John E. Hoover
`
`Linda Felton
`
`Steven Gelone
`
`Nicholas G. Popovick
`
`William J. Reilly, Jr
`
`Alfonso R. Gennaro
`
`Randy Hendrickson, Chair
`
`AUTHORS
`
`The 133 chapters of this edition of Remington were written by
`
`the editors, by members of the Editorial Board, and by the au-
`
`thors listed on pages xi to xv.
`
`Director
`
`Philip P Gerbino 1995-2005
`
`Twenty-first Edition—2005
`
`Published in the 185th year of the
`PHILADELPHIA COLLEGE OF PHARMACY AND SCIENCE
`
`
`
`
`
`
`
`

`

`
`
`
`
`Remington Historical/Biographical Data
`
`
`
`The following is a record of the editors and the dates of publi-
`cation of successive editions of this book, prior to the 13th
`Edition known as Remington’s Practice of Pharmacy and sub-
`sequently as Remington’s Pharmadeutical Sciences trhough
`the 20th edition.
`
`First Edition, 1886
`Second Edition, 1889
`Third Edition, 1897
`Fourth Edition, 1905
`Joseph P. Remington
`
`Fifth Edition, 1907
`Sixth Edition, 1917
`Joseph P. Remington
`
`Seventh Edition, 1926
`Editors
`E. Fullerton Cook
`Charles H. LaWall
`
`Eighth Edition, 1936
`Editors
`E. Fullerton Cook
`Charles H. LaWall
`
`Assisted by
`E. Fullerton Cook
`
`Associated Editors
`Ivor Griffith
`Adley B. Nichols
`Arthur Osol
`
`Ninth Edition, 1948
`Tenth Edition, 1951
`Editors
`E. Fullerton Cook
`Eric W. Martin
`
`Eleventh Edition, 1956
`Editors
`Eric W. Martin
`E. Fullerton Cook
`
`Twelfth Edition, 1961
`Editors
`Eric W. Martin
`E. Fullerton Cook
`E. Emerson Leuallen
`Arthur Osol
`Linwood F. Tice
`Clarence T. Van Meter
`
`Associated Editors
`E. Emerson Leuallen
`Arthur Osol
`Linwood F. Tice
`Clarence T. Van Meter
`
`Assistant to the Editors
`John E. Hoover
`
`
`
`
`Thirteenth Edition, 1965
`Editor-in-Chief
`Eric W. Martin
`Editors
`Grafton D. Chase
`Herald R. Cox
`Richard A. Deno
`Alfonso R. Gennaro
`Stewart C. Harvey
`
`Fourteenth Edition, 1970
`Chairman, Editorial Board
`Arthur Osol
`Editors
`Grafton D. Chase
`Richard A. Deno
`Alfonso R. Gennaro
`Melvin R. Gibson
`Stewart C. Harvey
`
`Managing Editor
`John E. Hoover
`
`Robert E. King
`E. Emerson Leuallen
`Author Osol
`Ewart A. Swinyard
`Clarence T. Van Meter
`
`Managing Editor
`John E. Hoover
`
`Robert E. King
`Alfred N. Martin
`Ewart A. Swinyard
`Clarence T. Van Meter
`
`Fifteenth Edition, 1975
`Chairman, Editorial Board
`Arthur Osol
`Editors
`John T. Anderson
`Cecil L. Bendush
`Grafton D. Chase
`Alfonso R. Gennaro
`Melvin R. Gibson
`
`Sixteenth Edition, 1980
`Chairman, Editorial Board
`Arthur Osol
`Editors
`Grafton D. Chase
`Alfonso R. Gennaro
`Melvin R. Gibson
`
`Seventeenth Edition, 1985
`Chairman, Editorial Board
`Alfonso R. Gennaro
`Editors
`Grafton D. Chase
`Ara H. DerMarderosian
`Stewart C. Harvey
`Daniel A. Hussar
`Thomas Medwick
`
`Eighteenth Edition, 1990
`Chairman, Editorial Board
`Alfonso R. Gennaro
`
`Editors
`Grafton D. Chase
`Ara H. DerMarderosian
`Stewart C. Harvey
`Daniel A. Hussar
`Thomas Medwick
`
`Managing Editor
`John E. Hoover
`
`C. Boyd Granberg
`Stewart C. Harvey
`Robert E. King
`Alfred N. Martin
`Ewart A. Swinyard
`
`C. Boyd Granberg
`Stewart C. Harvey
`Robert E. King
`Alfred N. Martin
`Ewart A. Swinyard
`Gilbert L. Zink
`
`Managing Editor
`John E. Hoover
`
`Edward G. Rippie
`Joseph B. Schwartz
`Ewart A. Swinyard
`Gilbert L. Zink
`
`Managing Editor
`John E. Hoover
`Editorial Assistant
`Bonnie Packer
`
`Edward G. Rippie
`Joseph B. Schwartz
`Ewart A. Swinyard
`Gilbert L. Zink
`
`vii
`
`

`

`
`
`viii
`
`REMINGTON HISTORICAL/BIOGRAPHICAL DATA
`
`Nineteenth Edition, 1995
`Chairman, Editorial Board Managing Editor
`Alfonso R. Gennaro
`John E. Hoover
`Editorial Assistant
`Bonnie Packer
`
`Editors
`Grafton D. Chase
`Ara H. DerMarderosian
`Glen R. Hanson
`Daniel A. Hussar
`Thomas Medwick
`
`Edward G. Rippie
`Joseph B. Schwartz
`H. Steve White
`Gilbert L. Zink
`
`Twentieth Edition, 2000
`Chairman, Editorial Board Managing Editor
`Alfonso R. Gennaro
`John E. Hoover
`Editorial Assistant
`Bonnie Packer
`
`Editors
`Ara DerMarderosian
`Glen R. Hanson
`Thomas Medwick
`Nicholas G. Popovich
`
`Roger L. Schnaare
`Joseph B. Schwartz
`H. Steve White
`
`
`
`
`

`

`
`
`
`
`Editorial Board
`
`
`
`Paul Beringer, PharmD, BCPS
`Associate Professor, Department of Pharmacy
`USC School of Pharmacy
`Los Angeles, CA
`Section Editor for Part 6
`
`Ara DerMarderosian, PhD
`Professor of Pharmacognosy
`Research Professor of Medicinal Chemistry
`University of the Sciences in Philadelphia
`Philadelphia, PA
`Section Editor for Part 1
`
`Linda Felton, PhD, BSPharm, RPh
`Associate Professor of Pharmaceutics
`University of
`New Mexico
`College of Pharmacy
`Albuquerque,
`NM
`Section Editor for Part 5
`
`Steven Gelone, PharmD
`Consultant
`AGE Consultants
`Wyndmoor, PA
`Section Editor for Part 7
`
`Pardeep K Gupta, PhD
`Associate Professor of Pharmaceutics
`Director of BS Program in Pharmaceutical Sciences
`University of the Sciences in Philadelphia
`Philadelphia, PA
`Section Editor for Parts 3 and 4
`
`John E Hoover, BSc (Pharm)
`Consultant, Biomedical Communications
`Swarthmore, PA
`Consulting Editor and Indexer
`
`Nicholas G Popovich, PhD
`Professor and Head
`Department of Pharmacy Administration
`University of Illinois at Chicago
`College of Pharmacy
`Chicago, IL
`Section Editor for Part 8
`
`William J Reilly, Jr, MBA
`K.W. Tunnell Consulting
`King of Prussia, PA
`Section Editor for Part 2
`
`Alfonso R Gennaro, PhD
`Professor Emeritus of Chemistry
`University of the Sciences in Philadelphia
`Philadelphia, PA
`Section Editor for Part 7
`
`Randy Hendrickson, MIPP
`Advanced Concepts Institute
`University of the Sciences in Philadelphia
`Philadelphia, PA
`Editor
`
`
`
`
`

`

`
`
`
`
`Authors
`
`
`
`Marie Abate, BS, PharmD / Professor of Clinical Pharmacy
`and Director, West Virginia Center for Drug and Health
`Information, School of Pharmacy, West Virginia University.
`Chapter 9, Clinical Drug Literature
`Steven R Abel, PharmD, FASHP / Professor and Head,
`Department of Pharmacy Practice, Purdue University
`School of Pharmacy and Pharmacal Sciences. Chapter 100,
`Professional Communications
`Bradley L Ackermann, PhD / Research Advisor, Lilly
`Research Laboratories, Eli Lilly & Co. Chapter 34, Instru-
`mental Methods of Analysis
`Mignon S Adams, MSLS / Associate Professor of Information
`Science; Chair of the Department of Information Science;
`Director of Library and Information Services, University of
`the Sciences in Philadelphia. Chapter 8, Information
`Resources in Pharmacy and the Pharmaceutical Sciences
`Michael J Akers, PhD / Director of Pharmaceutical Research
`and Development, Baxter Pharmaceutical Solutions, LLC.
`Chapter 41, Parenteral Solutions
`Adam W G Alani, MSc / Research Assistant, School of
`Pharmacy, University of Wisconsin-Madison. Chapter 47,
`Extended-Release and Targeted Drug Delivery Systems
`Loyd V Allen, Jr, PhD / Professor Emeritus, Department of
`Medicinal Chemistry and Pharmaceutics, College of Phar-
`macy, University of Oklahoma and Editor-In-Chief, Inter-
`national Journal of Pharmaceutical Compounding. Chapter
`105, Extemporaneous Prescription Compounding
`Heidi M Anderson, PhD / Professor and Assistant Dean,
`Education Innovation, College of Pharmacy, University of
`Kentucky. Chapter 97, Patient Communication
`Howard Y Ando, PhD / Director of Candidate Enabling
`and Development, Pfizer Global Research and Develop-
`ment. Chapter 38, Property-Based Drug Design and
`Preformulation
`R Jayachandra Babu, PhD / Research Associate, College
`of Pharmacy, Florida A&M University. Chapter 33,
`Chromatography
`Thomas A Barbolt, PhD, DABT / Senior Research Fellow,
`ETHICON, Somerville, NJ. Chapter 109, Surgical Supplies
`Kenneth N Barker, PhD / Distinguished Sterling Professor
`and Director, Center for Pharmacy Operations and Design,
`Harrison School of Pharmacy, Auburn University. Chapter
`95, Technology and Automation
`Sara J Beis, MS, RPh / Consultant, Akron, OH. Chapter 112,
`Re-Engineering Pharmacy Practice
`Robert W Bennett, MS, RPh / Associate Professor of Clinical
`Pharmacy; Director, Pharmacy Continuing Education, De-
`partment of Pharmacy Practice, Purdue University School of
`Pharmacy. Chapter 112, Re-Engineering Pharmacy Practice
`Paul M Beringer, PharmD / Associate Professor of Clinical
`Pharmacy, School of Pharmacy, University of Southern
`California. Chapter 59, Clinical Pharmacokinetics and
`Pharmacodynamics
`Richard J Bertin, PhD, RPh / Executive Director, Board of
`Pharmaceutical Specialties, Washington, DC. Chapter 120,
`Specialization in Pharmacy Practice
`Lawrence H Block, PhD / Professor of Pharmaceutics, Mylan
`School of Pharmacy, Duquesne University. Chapter 23,
`Rheology and Chapter 44, Medicated Topicals
`Allan D Bokser, PhD / Associate Director of Analytical
`Development, Neurocrine Biosciences, Inc. Chapter 52,
`Stability of Pharmaceutical Products
`Sanford Bolton, PhD / Visiting Professor, College of
`Pharmacy, University of Arizona. Chapter 12, Statistics
`
`Michael R Borenstein, RPh, PhD / Associate Professor and
`Chairman, Department of Pharmaceutical
`Sciences,
`Temple University School of Pharmacy. Chapter 78,
`General Anesthetics; Chapter 85, Central Nervous System
`Stimulants
`Joseph I Boullata, PharmD, BCNSP / Professor of
`Pharmacy Practice, Temple University School of Pharmacy.
`Chapter 92, Nutrients and Associated Substances
`Bill
`J Bowman, PhD, RPh / Assistant Professor of
`Pharmaceutical Sciences, College of Pharmacy—Glendale,
`Midwestern University. Chapter 21, Colloidal Dispersions;
`Chapter 26, Natural Products
`Leslie Ann Bowman, AMLS / Associate Professor of
`Information Science and Coordinator of Instructional
`Services, Joseph W England Library, University of the
`Sciences in Philadelphia. Chapter 8, Information Resources
`in Pharmacy and the Pharmaceutical Sciences
`Cynthia A Burman, BS, PharmD / Medical Information
`Scientist, GlaxoSmithKline, Philadelphia, PA. Chapter 75,
`Diuretic Drugs
`Paul M Bummer, PhD / Associate Professor of Pharmaceuti-
`cal Sciences, College of Pharmacy, University of Kentucky.
`Chapter 20, Interfacial Phenomena
`Daniel J Canney, PhD / Associate Professor of Medicinal
`Chemistry, Department of Pharmaceutical Sciences,
`Temple University School of Pharmacy. Chapter 71,
`Cholinomimetic Drugs and Chapter 73, Antimuscarinic and
`Antispasmodic Drugs
`Bradley C Cannon, PharmD / Clinical Assistant Professor,
`University of Illinois at Chicago, College of Pharmacy. Chap-
`ter 122, Development of a Pharmacy Care Plan and Patient
`Problem Solving
`F Lee Cantrell, PharmD / Assistant Clinical Professor of
`Pharmacy, School of Pharmacy, University of California,
`San Francisco, San Diego Program; Assistant Director, San
`Diego Division, California Poison Control System, Univer-
`sity of California San Diego Medical Center. Chapter 103,
`Poison Control
`Ajai Chaudhary, MPharm, PhD / Head, Drug Disposition,
`Lilly Research Laboratories, Eli Lilly & Co. Chapter 34,
`Instrumental Methods of Analysis
`Amy Christopher, MS / Assistant Professor of Information
`Science and Web Manager, University of the Sciences
`in Philadelphia. Chapter 8, Information Resources in
`Pharmacy and the Pharmaceutical Sciences
`Michael M Crowley, PhD / Vice President, Drug Delivery
`Technology and Manufacturing Services, PharmaForm,
`LLC. Chapter 39, Solutions, Emulsions, Suspensions, and
`Extracts
`Ara H DerMarderosian, PhD / Professor of Pharmacognosy;
`Research Professor of Medicinal Chemistry, University of
`the Sciences in Philadelphia. Chapter 7, Pharmacists and
`Public Health; Chapter 49, Biotechnology and Drugs;
`Chapter 93, Pesticides; Chapter 132, Complementary and
`Alternative Medical Health Care
`Xuan Ding, PhD / School of Pharmacy, University of Wiscon-
`sin-Madison. Chapter 47, Extended-Release and Targeted
`Drug Delivery Systems
`Clarence A Discher, PhD / Deceased. Chapter 24, Inorganic
`Pharmaceutical Chemistry
`William R Doucette, PhD / Associate Professor, Director for
`the Center to Improve Medication Use in the Community,
`College of Pharmacy, The University of Iowa. Chapter 116,
`Marketing Pharmaceutical Care Services
`
`
`
`
`

`

`
`
`xii
`
`AUTHORS
`
`Teresa Pete Dowling, PharmD / Director, Promotional
`Regulatory Affairs, AstraZeneca LP. Chapter 5, Pharmacists
`in Industry
`G L Drusano, MD / Co-Director, Ordway Research Institute.
`Chapter 63, Pharmacokinetics / Pharmacodynamics in Drug
`Development
`John E Enders, PhD, MBA / Director of Quality Assurance,
`Delmont Laboratories, Swarthmore, PA. Chapter 51,
`Quality Assurance and Control
`Sharon Murphy Enright, MBA, RPh / President, Envision
`Change, LLC, New Berlin, WI. Chapter 102, Providing a
`Framework for Ensuring Medication Use Safety
`Donald O Fedder, DrPH, FAPhA, BOCO / Professor,
`Pharmaceutical Health Services Research and Epidemiol-
`ogy and Preventive Medicine, University of Maryland
`Schools of Pharmacy and Medicine. Chapter 110, Health
`Accessories
`Bill G Felkey, MS / Professor, Pharmacy Care Systems,
`Harrison School of Pharmacy, Auburn University. Chapter
`95, Technology and Automation
`Linda A Felton, PhD / Associate Professor of Pharmaceutics,
`College of Pharmacy, University of New Mexico Health
`Sciences Center. Chapter 37, Powders; Chapter 48, The New
`Drug Approval Process and Clinical Trial Design
`Joseph L Fink III, BS Pharm, JD / Vice President for
`Corporate Relations and Economic Outreach; Professor of
`Pharmacy, College of Pharmacy, University of Kentucky.
`Chapter 1,
`Scope of Pharmacy; Chapter 111, Laws
`Governing Pharmacy
`Michael R Franklin, PhD / Professor, Department of
`Pharmacology and Toxicology, University of Utah. Chapter
`57, Drug Absorption, Action, and Disposition; Chapter 91,
`Enzymes
`Donald N Franz, PhD / Professor Emeritus, Department of
`Pharmacology and Toxicology, University of Utah. Chapter
`57, Drug Absorption, Action, and Disposition
`Raymond E Galinsky, PharmD / Professor of Pharmaceu-
`tics, School of Pharmacy and Pharmacal Sciences, Purdue
`University. Chapter 58, Basic Pharmacokinetics and
`Pharmacodynamics
`Daniele K Gelone, PharmD / Assistant Professor of Clinical
`Pharmacy, Department of Pharmacy Practice and Pharmacy
`Administration, Philadelphia College of Pharmacy, Univer-
`sity of the Sciences in Philadelphia. Chapter 87, Immunoac-
`tive Drugs
`Steven P Gelone, PharmD / Consultant, AGE Consultants,
`Wyndmoor, PA. Chapter 88, Parasiticides; Chapter 89,
`Immunizing Agents; Chapter 90, Anti-Infectives
`Alfonso R Gennaro, PhD / Emeritus Professor, Department
`of Chemistry and Biochemistry, University of the Sciences
`in Philadelphia. Chapter 25, Organic Pharmaceutical
`Chemistry
`Doug Geraets, PharmD, FCCP, BCPS / Clinical Pharmacy
`Specialist-Ambulatory Care, Iowa City VA Medical Center;
`Adjunct Associate Professor, Clinical and Administrative
`Pharmacy, College of Pharmacy, The University of Iowa.
`Chapter 121, Pharmacists and Disease State Management
`Steven J Gilbert, RPh, PharmD (ec) / excelleRx Inc., Philadel-
`phia, PA. Chapter 4, The Practice of Community Pharmacy
`Martin C Gregory, BM, BCh, DPhil / Professor of Medicine,
`Division of Nephrology, University of Utah School of
`Medicine. Chapter 56, Diseases: Manifestations and Patho-
`physiology
`Pardeep K Gupta, PhD / Associate Professor, Philadelphia
`College of Pharmacy, University of the Sciences
`in
`Philadelphia. Chapter 16, Solutions and Phase Equilibria;
`Chapter 27, Drug Nomenclature USAN
`Amy Marie Haddad, PhD / Professor, School of Pharmacy
`and Health Professions, Creighton University. Chapter 84,
`Application of Ethical Principles to Practice Dilemmas
`Dennis D Hager, RPh, PharmD(c) / excelleRx Inc., Philadel-
`phia, PA. Chapter 4, The Practice of Community Pharmacy
`
`Donald E Hagman PhD / Vice President, Scientific Affairs,
`CardinalHealth, Inc. Chapter 40, Sterilization
`William A Hess, BSc Pharm / Captain and Pharmacist
`Director, FDA Center Consultant, United States Public
`Health Service. Chapter 6, Pharmacists in Government
`Gregory J Higby, PhD / Director, American Institute of the
`History of Pharmacy, School of Pharmacy, University of
`Wisconsin-Madison. Chapter 2, Evolution of Pharmacy
`James R Hildebrand III, BS, PharmD / Director of Clinical
`Pharmacy, Alfred I du Pont Hospital for Children. Chapter
`9, Clinical Drug Literature
`William B Hladik III, MS, FASHP, FAPhA / Associate
`Professor of Pharmacy Practice, College of Pharmacy,
`University of New Mexico and Director, Australian Radio-
`pharmacy Network, Bristol-Myers Squibb Medical Imaging,
`Melbourne, Victoria, Australia. Chapter 29, Fundamentals
`of Medical Radionuclides
`Marlon Honeywell, PharmD / Associate Professor of
`Pharmacy Practice, College of Pharmacy, Florida A&M
`University. Chapter 125, Diagnostic Self-Care
`John E Hoover, BSc Pharm, RPh / Consultant, Biomedical
`Communications. Chapter 66, Gastrointestinal and Liver
`Drugs; Chapter 69, Respiratory Drugs; Chapter 74, Skeletal
`Muscle Relaxants; Chapter 76, Uterine and Antimigraine
`Drugs; Chapter 81, Antiepileptic Drugs; Chapter 84,
`Histamine and Antihistaminic Drugs
`Daniel A Hussar, PhD / Remington Professor of Pharmacy,
`Philadelphia College of Pharmacy, University of the
`Sciences in Philadelphia. Chapter 98, Patient Compliance
`and Chapter 104, Drug Interactions
`Michael F Imperato, PharmD / excelleRx Inc., Philadelphia,
`PA. Chapter 4, The Practice of Community Pharmacy
`Matthew K Ito, PharmD, FCCP, BCPS / Professor and Vice
`Chair of Pharmacy Practice, TJ Long School of Pharmacy
`and Health Sciences, University of the Pacific; Director,
`Cardiac Rehabilitation Cholesterol Clinic, San Diego VA
`Healthcare System. Chapter 121, Pharmacists and Disease
`State Management
`Timothy J Ives, PharmD, MPH, BCPS, FCCP / Associate
`Professor of Pharmacy and Medicine, School of Pharmacy,
`University of North Carolina at Chapel Hill. Chapter 7,
`Pharmacists and Public Health
`Rajni Jani, PhD / Senior Director, Department of Pharma-
`ceutics, Alcon Research, Ltd. Chapter 43, Ophthalmic
`Preparations
`Tara M Jenkins, MS, PharmD / Assistant Professor of
`Pharmacy Practice,
`School
`of Pharmacy, Hampton
`University. Chapter 125, Diagnostic Self-Care
`Steven B Johnson, PharmD / Division of Pharmaceutical
`Evaluation II, Food and Drug Administration, Rockville,
`MD. Chapter 53, Bioavailability and Bioequivalency Testing
`Robert
`Jordan, PharmD Candidate /
`College
`of
`Pharmacy—Glendale, Midwestern University. Chapter 26,
`Natural Products
`Calvin H Knowlton, RPh, MDiv, PhD, FACA / excelleRx
`Inc., Philadelphia, PA. Chapter 4, The Practice of Commu-
`nity Pharmacy
`David J Kroll, PhD / Senior Research Pharmacologist, Natu-
`ral Products Laboratory, Research Triangle Institute (RTI).
`Chapter 49, Biotechnology and Drugs
`Vijay Kumar, MS, MBA / Chief Operating Officer, Acura
`Pharmaceuticals. Chapter 35, Dissolution
`John C Lang, PhD / Director of Emerging Technologies, Alcon
`Research, Ltd. Chapter 43, Ophthalmic Preparations
`Arthur J Lawrence, PhD, RPh / Rear Admiral and Assistant
`Surgeon General, Deputy Assistant Secretary for Health
`Operations, United States Public Health Service. Chapter 6,
`Pharmacists in Government
`Eric J Lien, PhD / Professor of Pharmacy/Pharmaceutics and
`Biomedicinal Chemistry, School of Pharmacy, University of
`Southern California. Chapter 13, Molecular Structure, Prop-
`erties, and States of Matter
`
`
`
`
`

`

`
`
`AUTHORS
`
`xiii
`
`Hetty A Lima, RPh, FASHP / Vice President, Marketing,
`Caremark, Inc. Chapter 130, Aseptic Processing for Home
`Infusion Pharmaceuticals
`Sylvia H Liu, BVM, DACVP / Vice President, Research and
`Development, ETHICON, Somerville, NJ. Chapter 109,
`Surgical Supplies
`Stan G Louie, PharmD / Associate Professor of Pharmacy,
`University of Southern California. Chapter 60, Principles of
`Immunology
`Eva Lydick, PhD / Chief Research Officer, Lovelace Clinic
`Foundation. Chapter 118, Pharmaceutical Risk Management
`Elaine Mackowiak, PhD, RPh / Professor of Pharmaceutical
`Chemistry (School of Pharmacy) and Clinical Associate Pro-
`fessor of Diagnostic Imaging (School of Medicine), Temple
`University. Chapter 64, Diagnostic Drugs and Reagents
`Henry J Malinowski, PhD / Division of Pharmaceutical Eval-
`uation II, Food and Drug Administration, Rockville, MD.
`Chapter 53, Bioavailability and Bioequivalency Testing
`Michael A Mancano, PharmD / Associate Professor of Clini-
`cal Pharmacy, Temple University School of Pharmacy.
`Chapter 77,
`Hormones and Hormone Antagonists
`Laura A Mandos, BS, PharmD / Associate Professor of
`Clinical Pharmacy, Philadelphia College of Pharmacy,
`University of the Sciences in Philadelphia. Chapter 80,
`Antianxiety Agents and Hypnotic Drugs
`Anthony S Manoguerra, PharmD / Professor of Clinical
`Pharmacy, School of Pharmacy, University of California, San
`Francisco, San Diego Program; Director, San Diego Division,
`California Poison Control System, University of California
`San Diego Medical Center. Chapter 103, Poison Control
`Robert W Martin III, MD / Chairman, Department of
`Dermatology; Chief, Division of Dermatopathology, Arnett
`Clinic, Lafayette, Indiana; Clinical Assistant Professor,
`Department of Dermatology, Indiana University School of
`Medicine. Chapter 133, Chronic Wound Care
`Robert L. McCarthy, PhD / Dean and Professor, School of
`Pharmacy, University of Connecticut. Chapter 3, Ethics and
`Professionalism
`Michael R McConnell, RPh / Founder and Consultant,
`National Notification Center. Chapter 115, Product Recalls
`and Withdrawals
`Randal P McDonough, PharmD, MS / Associate Professor
`(Clinical), Director of Practice Development and Educa-
`tional Programs, College of Pharmacy, The University of
`Iowa. Chapter 116, Marketing Pharmaceutical Care Services
`William F McGhan, PharmD, PhD / Professor of Pharmacy
`and Health Policy, Department of Pharmacy Practice and
`Pharmacy Administration, Philadelphia College of Phar-
`macy, University of the Sciences in Philadelphia. Chapter
`113, Pharmacoeconomics
`Howard L McLeod, PharmD / Associate Professor, Depart-
`ment of Medicine, Washington University School of
`Medicine. Chapter 62, Pharmacogenomics
`Mary Lynn McPherson, PharmD / Associate Professor,
`Pharmacy Practice and Science Department, School of
`Pharmacy, University of Maryland. Chapter 110, Health
`Accessories
`Thomas Medwick, PhD / Emeritus Professor of Pharmaceu-
`tical Chemistry, School of Pharmacy, Rutgers University.
`Chapter 24, Inorganic Pharmaceutical Chemistry
`Robert Middleton, PharmD / Department of Pharmacy,
`Beebe Medical Center, Lewes, DE. Chapter 61, Adverse
`Drug Reactions Clinical Toxicology
`Michael Montagne, PhD / Professor of Social Pharmacy,
`Massachusetts College of Pharmacy—Boston. Chapter 3,
`Ethics and Professionalism and Chapter 99, Drug Education
`Louis A Morris, PhD / President, Louis A Morris and Associ-
`ates, Inc. Chapter 118, Pharmaceutical Risk Management
`Michael D Murray, PharmD, MPH / Professor and Chair,
`Pharmaceutical Policy and Evaluative Sciences, School of
`Pharmacy, The University of North Carolina at Chapel Hill.
`Chapter 108, Pharmacoepidemiology
`
`Gail D Newton, PhD, RPh / Associate Professor of Pharmacy
`Practice, School of Pharmacy and Pharmacal Sciences,
`Purdue University. Chapter 123, Ambulatory Patient Care
`Jeffrey P Norenberg, MS, PharmD, BCNP, FASHP,
`FAPhA / Associate Professor and Director, Radiopharma-
`ceutical Sciences, College of Pharmacy, University of New
`Mexico Health Sciences Center. Chapter 29,
`Fundamentals of
`Medical Radionuclides
`Robert E O’Connor, PhD / Senior Director, European Techni-
`cal Operations, Janssen Pharmaceutica. Chapter 37, Powders
`Judith A O'Donnell, MD / Associate Professor of Medicine
`and Public Health, Drexel University Schools of Medicine
`and Public Health. Chapter 90, Anti-Infectives
`Patrick B O’Donnell, PhD / Associate Director of Product
`Development, Neurocrine Biosciences, Inc. Chapter 52,
`Stability of Pharmaceutical Products
`Clyde M Ofner III, PhD / Associate Professor and Director,
`Graduate Program in Pharmaceutics, Philadelphia College
`of Pharmacy, University of the Sciences in Philadelphia.
`Chapter 21, Colloidal Dispersions
`Carol Ott, PharmD, BCPP / Affiliate Assistant Professor of
`Pharmacy Practice, School of Pharmacy, Purdue University.
`Chapter 129, Long-Term Care
`James A Palmieri, PharmD / Assistant Professor of
`Pharmacy Practice, TJ Long School of Pharmacy and Health
`Sciences, University of the Pacific; Clinical Pharmacy
`Specialist, Cardiovascular Disease Management, The Mercy
`Heart Institute, Sacramento, CA. Chapter 121, Pharmacists
`and Disease State Management
`Susie H Park, PharmD / Assistant Professor of Clinical
`Pharmacy, University of Southern California. Chapter 60,
`Principles of Immunology
`John H Parker, PhD / President, Tech Manage Associates,
`Clarks Summit, PA. Chapter 51, Quality Assurance and
`Control
`Payal Patel, BSc (Pharm), PharmD / Evidence-Based
`Pharmacy Consultant, London Health Sciences Centre,
`London, Ontario, Canada. Chapter 128, Emergency Medicine
`Pharmacy Practice
`Garnet E Peck, PhD / Professor Emeritus of Industrial and
`Physical Pharmacy, School of Pharmacy and Pharmacal
`Sciences, Purdue University. Chapter 36, Separation
`Thomas G Pettinger, BSP, BOCO / Staff Orthotist, Great
`Plains Health Company, Fargo, North Dakota. Chapter 110,
`Health Accessories
`Peggy Piascik, PhD / Associate Professor of Pharmacy -
`Practice, University of Kentucky. Chapter 97, Patient
`Communication
`James A Ponto, MS, BCNP / Chief Nuclear Pharmacist and
`Professor (Clinical), University of Iowa Hospitals & Clinics
`and College of Pharmacy University of Iowa. Chapter 106,
`Nuclear Pharmacy Practice
`Cathy Y Poon, PharmD / Associate Professor of Clinical Phar-
`macy Philadelphia College of Pharmacy, University of the
`Sciences in Philadelphia. Chapter 18, Tonicity, Osmoticity,
`Osmolality, and Osmolarity; Chapter 32, Clinical Analysis
`Stuart C Porter, PhD / President, PPT, Hatfield, PA. Chapter
`46, Coating of Pharmaceutical Dosage Forms
`W Steven Pray, BS (Pharm), MPH, PhD / Bernhardt
`Professor of Nonprescription Drugs and Devices, College of
`Pharmacy, Southwestern Oklahoma State University.
`Chapter 124, Self-Care
`Shelly J Prince, PhD / Associate Professor of Pharmaceutics,
`College
`of Pharmacy, Southwestern Oklahoma State
`University. Chapter 11, Metrology and Pharmaceutical
`Calculations
`Barrett E Rabinow, PhD / Senior Director, Strategic Techni-
`cal Development, Baxter Healthcare Corporation, Round
`Lake, IL. Chapter 54, Plastic Packaging Materials
`Galen W Radebaugh, PhD / Vice President of Analytical
`Development, Schering-Plough Research Institute. Chapter
`38, Property-Based Drug Design and Preformulation
`
`
`
`
`

`

`
`
`xiv
`
`AUTHORS
`
`Robert B Raffa, PhD / Professor of Pharmacology, Temple
`University School of Pharmacy. Chapter 83, Analgesic,
`Antipyretic, and Anti-Inflammatory Drugs
`Dennis W Raisch, RPh, PhD / Associate Center Director,
`Scientific Affairs, VA Cooperative Studies Program Clinical
`Research Pharmacy Coordinating Center, Albuquerque.
`Chapter 48, The New Drug Approval Process and Clinical
`Trial Design
`William J Reilly, Jr, RPh, MBA / Managing Consultant,
`Tunnell Consulting, King of Prussia, PA. Chapter 55,
`Pharmaceutical Necessities
`June E Riedlinger, RPh, PharmD / Adjunct Associate
`Professor, Southwest College of Naturopathic Medicine and
`Adjunct Associate Professor of Pharmacy Practice, School of
`Pharmacy—Boston, Massachusetts College of Pharmacy
`and Health Sciences. Chapter 132, Complementary and
`Alternative Medical Health Care
`Joseph R Robinson, PhD / Professor of Pharmacy and
`Ophthalmology, School of Pharmacy, University of Wiscon-
`sin-Madison. Chapter 47, Extended-Release and Targeted
`Drug Delivery Systems
`Mark G Robson, PhD, MPH / Chairman, Environmental and
`Occupational Health, UMDNJ School of Public Health.
`Chapter 93, Pesticides
`Robert E Roehrs, PhD / Vice President (Retired), Depart-
`ment of Drug Regulatory Affairs, Alcon Research, Ltd.
`Chapter 43, Ophthalmic Preparations
`Lisa Cencia Rohan, PhD / Assistant Professor of Pharma-
`ceutical Sciences,
`School of Pharmacy, University of
`Pittsburgh. Chapter 23, Rheology
`Theodore J Roseman, PhD / Vice President, Scientific
`Affairs, Baxter Healthcare Corporation, Round Lake, IL.
`Chapter 54, Plastic Packaging Material
`Joseph T Rubino, PhD / Principal Research Scientist,
`Chemical
`and
`Pharmaceutical
`Development,
`Wyeth
`Research. Chapter 22, Coarse Dispersions
`Orapin P Rubino, PhD / Group Leader, Formulation
`Development, Glatt Air Techniques, Inc. Chapter 22, Coarse
`Dispersions
`Charles Ruchalski, PharmD / Assistant Professor of Clinical
`Pharmacy, School of Pharmacy, Temple University. Chapter
`77, Hormones and Hormone Antagonists
`Maria I Rudis, PharmD / Director, Emergency Medicine/
`Critical Care Pharmacy Residency Program; Assistant
`Professor of Clinical Pharmacy and Emergency Medicine,
`University of Southern California. Chapter 128, Emergency
`Medicine Pharmacy Practice
`Edward M Rudnic, PhD / President and Chief Executive
`Officer, Advancis Pharmaceutical Corp. Chapter 45, Oral
`Solid Dosage Forms
`Michael T Rupp, PhD, RPh / Professor of Pharmacy
`Administration, College of Pharmacy, Midwestern Univer-
`sity—Glendale. Chapter 117, Documenting, Billing, and
`Reimbursement for

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket