(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
`
`(19) World Intellectual Property Organization
`International Bureau
`
`
`
`
`
`1111111111110111111111110010 11111111111111111111111111111111111111111111111
`
`(43) International Publication Date
`18 September 2003 (18.09.2003)
`
`PCT
`
`(10) International Publication Number
`WO 03/075991 Al
`
`(51)
`
`International Patent Classification':
`
`A61M 16/00
`
`(21)
`
`International Application Number:
`
`PCT/IB03/01422
`
`(22)
`
`International Filing Date: 10 March 2003 (10.03.2003)
`
`(25)
`
`Filing Language:
`
`(26)
`
`Publication Language:
`
`English
`
`English
`
`(30)
`
`Priority Data:
`60/362,441
`
`8 March 2002 (08.03.2002) US
`
`(71) Applicant (for all designated States except US): KAERYS
`S.A. [FR/FR]; 50, Boulevard Stalingrad, F-06300 Nice
`(FR).
`
`(72) Inventors; and
`(75) Inventors/Applicants (for US only): DELACHE, Alain
`[FR/FR]; 15, avenue de la Roseraie, F-06300 Nice (FR).
`DELACHE, Veronique [FR/FR]; 15, avenue de la
`Roseraie, F-06300 Nice (FR).
`
`(74) Agent: BONNEAU, Gerard; Cabinet Bonneau, Les Tais-
`sounieres HB3, 1681, route des Dolines, F-06560 Sophia
`Antipolis (FR).
`
`(81) Designated States (national): AE, AG, AL, AM, AT, AU,
`AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU,
`CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH,
`GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC,
`LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW,
`MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE,
`SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ,
`VC, VN, YU, ZA, ZM, ZW.
`
`(84) Designated States (regional): ARIPO patent (GH, GM,
`KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW),
`Eurasian patent (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM),
`European patent (AT, BE, BG, CH, CY, CZ, DE, DK, EE,
`ES, H, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO,
`SE, SI, SK, TR), OAPI patent (BF, BJ, CF, CG, CI, CM,
`GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
`
`Published:
`
` with international search report
`
`[Continued on next page]
`
`=
`
`(54) Title: APPARATUS TO ASSIST A PATIENT'S BREATHING WITH A VARIABLE RAMP PERIOD TO RISE TO TREAT-
`MENT PRESSURE
`
`T
`
`Po
`
`S t
`
`t,
`
`E2
`
`-•E3
`
`e
`
`1
`t2 t3
`
`is
`
`N
`
`O
`
`(57) Abstract: The invention concerns an apparatus (1) to assist a patient respiration by delivering air to a patient trough a mask
`(20), comprising wherein a ramp module (10) connected to a control unit (2) in order to provide the control unit with the value of
`pressure PM to settle at said mask (20), so that when said apparatus (1) starts functioning, the pressure progressively rises until the
`pressure of treatment PTi the apparatus (1) further comprising a comparator connected to the ramp module (10), at least one means
`for detectin
`g the patient's breathing parameters and sending them to said comparator, so that the comparator is able to determine that
`an event (E1, E2 or E3) occurs in patient's breathing and to send the corresponding data to the ramp module (10) which provides the
`control unit (2) with a value of pressure PM that will speed up with respect of time, so that the rise of pressure at patient's mask (20)
`is accelerated.
`
`ResMed Inc. Exhibit 1034
`Page 1 of 16
`
`

`

`WO 03/075991 Al 1111IHROMININ 10 01 1 Mg 1 11 Ell II INIMMEINNIE
`
`For two-letter codes and other abbreviations, refer to the "Guid-
`ance Notes on Codes and Abbreviations" appearing at the begin-
`ning of each regular issue of the PCT Gazette.
`
`ResMed Inc. Exhibit 1034
`Page 2 of 16
`
`

`

`WO 03/075991
`
`PCT/IB03/01422
`
`1
`
`Apparatus to assist a patient's breathing with a variable
`
`ramp period to rise to treatment pressure
`
`5 Technical field
`
`This invention concerns the field of apparatus to assist
`
`a patient respiration and more specifically an apparatus
`
`bringing progressively to the pressure of treatment the air
`
`the patient is provided with.
`
`10
`
`Background art
`In many treatments apparatus are used to provide
`
`patients with air. More frequently they are used for
`patients with a breathing deficiency caused for example by
`15 the weakness of the breathing system or by obstructive
`apneas during the sleep. In those cases it is important to
`control the pressure of the air delivered to the patient.
`With respiratory insufficient patients, apparatus providing
`air at a higher pressure help to compensate the weakness of
`20 the patients lungs. In the case of patients suffering of
`sleep apneas, providing the air at a higher pressure
`removes the obstruction of the upper airways.
`The pressure of treatment is usually not strong enough
`to wake the patient up, but can prevent him from falling
`25 asleep. An implementation of treatments apparatus is to
`wait for the patient to fall asleep before providing air
`under the treatment pressure. The classical solution is to
`have a ramp period, which is a slow increase of the
`delivered pressure from a low level to the treatment
`
`30 pressure.
`Still to enhance the comfort of the patient, it is
`disclosed in patent US5,492,113 and US5,970,975 an
`apparatus wherein several cycles of ramp are provided on
`patient's conscious demand. The cycles actuated after the
`35 first cycle rise faster in pressure. All those ramps are
`
`ResMed Inc. Exhibit 1034
`Page 3 of 16
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`

`

`WO 03/075991
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`PCT/IB03/01422
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`2
`
`predetermined in shape and duration. The patient can also
`
`select a fastest shape of ramp or select one special shape
`
`in order to fall asleep more easily. This selection being
`
`made among different predetermined shapes of ramp. However,
`
`5 such devices require from the patient a minimum of
`
`consciousness to activate the ramp cycles. This is not
`
`really very efficient to fall asleep and it is not possible
`
`when the patient as fallen asleep.
`
`Moreover each ramp can not be modified during the time
`
`10 when the ramp is activated.
`
`Summary of the invention
`
`The first object of the invention is to provide a ramp
`
`that would be able to modulate automatically, especially when
`
`15 the patient falls asleep.
`
`A second object of the invention is to provide in any
`
`case a maximum of time in rise of pressure, in order to apply
`
`the treatment in any case.
`
`The invention thus concerns an apparatus to assist a
`
`20 patient respiration by delivering air to a patient trough a
`
`mask, comprising:
`
`- a blower to provide the patient with air under a treatment
`
`pressure,
`
`- a control unit to adjust the pressure delivered by the
`
`25 blower at the level of the patient's mask,
`
`- a ramp module connected to the control unit in order to
`
`provide the control unit with the value of pressure PM to
`
`settle at the mask, so that when the apparatus starts
`
`functioning, the pressure progressively rises until the
`
`30 pressure of treatment PT;
`the apparatus comprising a comparator connected to the ramp
`
`module, means for detecting the patient's breathing parameters
`
`and sending them to said comparator, in order that in response
`to breathing parameters, the comparator is able to determine
`
`35 that an event occurs in patient's breathing and to send the
`
`corresponding data to the ramp module which provides the
`
`ResMed Inc. Exhibit 1034
`Page 4 of 16
`
`

`

`WO 03/075991
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`PCT/IB03/01422
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`3
`
`control unit with a value of pressure PM that will speed up
`
`with respect of the time, so that the rise of pressure at
`
`patient's mask is accelerated.
`
`In an implementation of the invention, the value of
`
`5 pressure PM has always maximum and/or minimum limits so that
`
`the increase of pressure is also limited in minimum and/or
`
`maximum.
`
`Such an apparatus has the advantage to generate a ramp
`
`period which can be modulated in the same ramp, according to
`
`10 patient's breathing parameters.
`
`Brief description of figures
`
`The purposes, objects and characteristics of the
`
`invention will become more apparent from the following
`
`15 description when taken in conjunction with the accompanying
`
`drawings in which:
`
`Figure 1 represents the apparatus schema,
`
`Figure 2 represents the pressure delivered to the
`
`patient's mask according to special events occurring in
`
`20 patient's breathing,
`
`Figure 3 represents the domain of pressure increase, and
`
`Figure 4 represents the block diagram for the ramp
`
`period.
`
`25 Detailed description of the invention
`
`The apparatus according to the present invention is able
`to generate a ramp period which can be modulated in respect of
`the time required by the patient for falling asleep.
`The apparatus as represented in figure 1 comprises a
`30 blower 4 to provide the patient with air. This blower is
`connected to a tube 8 on a first extremity, the second
`extremity being connected to the mask 20 wherein the patient
`breathes. A control unit 2 provides the blower 10 with the
`electrical control required to enable the blower to function
`35 in order to set a given pressure at the patient's mask or
`blower's outlet. This pressure could be by a pressure
`
`ResMed Inc. Exhibit 1034
`Page 5 of 16
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`4
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`transducer 6 at the mask level or at the tube extremity, which
`
`is connected to the mask. A ramp module 10 is connected to the
`
`control unit 2 and to the pressure transducer 6. The ramp
`
`module provides the control unit 2 with the pressure at the
`
`5 patient's mask and with the pressure to settle at the
`
`patient's mask at the starting of the apparatus 1 functioning.
`
`During the treatment the control unit 2 is able to detect
`
`breathing events according to the pressure sensor 6 or any
`
`other way to evaluate or measure the patient's airflow. Such
`
`10 detection can be given by airflow sensors which provide the
`
`control unit with pressure parameters, the control units being
`
`thus able to detect that an event is occurring.
`
`The apparatus according to the present invention is able
`
`to modulate the rise in pressure during one single ramp
`
`15 period, which is impossible to perform for apparatus of prior
`
`art. The apparatus comprises a ramp module 10 connected to the
`
`control unit 2 in order to provide the control unit with the
`
`value of pressure PM to settle at the patient's mask, so that
`
`when said apparatus starts functioning, the pressure
`
`20 progressively rises until the pressure of treatment PT. The
`
`apparatus comprises a comparator which is not represented in
`
`figurel and that can be comprised in the control unit 2. This
`
`comparator is connected to the ramp module 10. The apparatus
`
`comprise also at least one means for detecting the patients
`
`25 breathing parameters and sending them to said comparator, in
`
`order that in response to said breathing parameters, the
`comparator is able according to determine that an event occurs
`
`in patient breathing and to send the corresponding data to the
`
`ramp module which provide the control unit 2 with a value of
`
`30 pressure PM that will speed up in respect of the time, so that
`
`the rise of pressure at patient's mask is accelerated.
`
`According to a preferred embodiment, the ramp module 10
`provides the value of pressure PM being a linear function of
`
`time wherein the increase coefficient KRP is constant, said
`35 ramp module increasing that coefficient of a constant value KE
`
`ResMed Inc. Exhibit 1034
`Page 6 of 16
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`

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`5
`
`when the control unit 2 send a data corresponding to the event
`which occurred.
`
`In the apparatus 1 according to the present invention, a
`minimum speed of rise in pressure until the treatment pressure
`5 is set, as represented by the curve C2 on figure 3. This
`minimum rise of pressure in respect of time is called in the
`
`present application a safety ramp C2. Before the ramps period
`starts at the instant ts, a minimum starting pressure Po is
`delivered. After the instant ts, even if the patient is not
`
`10 asleep, the pressure at the mask will start rising. In any
`
`case at the instant tT, the treatment pressure will be
`
`reached; this means that the curve C2 represents the minimum
`
`speed of rise in pressure. In a preferential implementation of
`
`the invention, the minimum speed of rise in pressure is
`
`15 proportional to time, the coefficient to rise in pressure
`
`according to time being Ksp. Also it can be set a maximum of
`
`rise in pressure as represented by the curve C1 on figure 3.
`
`The maximum of rise in pressure can also be given a linear
`
`function of time. Between these two limits the rising of the
`
`20 pressure can be modulated by the control unit 2 in respect of
`
`the patient's falling asleep. That is to say that whenever any
`
`events occurs or not, the pressure provided at the patient's
`
`mask PPM before the time of plain treatment tT will be
`
`comprised between these two limits, this domain of pressure
`
`25 variations being represented in figure 3 by the hachures.
`
`When a patient is asleep his respiration becomes stable,
`
`this is used to detect the instant when the patient falls
`
`asleep. Another way to detect when the patient falls asleep is
`
`to detect the drop of frequency between the awake rate
`30 breathing and the awake breathing. As represented in figure 4
`
`and according to a preferential implementation, the control
`
`unit 2 transmits the ramp module an output average pressure
`
`value PM which is the pressure value required to patient's
`
`mask. When the patient is about to fall asleep, his
`35 respiration becomes stable. In that case the PM value is
`increased, preferentially as a linear function of time, the
`
`ResMed Inc. Exhibit 1034
`Page 7 of 16
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`

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`6
`
`proportional coefficient being KRP. If the pressure value PM is
`inferior to the safety ramp pressure PSR, the pressure PM is
`set to the value of the safety ramp pressure PSR, which is in
`a preferential implementation calculated by the module ramp 10
`5 by multiplying the time spent from the beginning of the ramp
`routine to the present time by the coefficient Ksp. When the
`pressure value PM equals or is superior to the treatment
`pressure PT, the PM pressure is maintained equal to the
`treatment pressure value PT. On the contrary the control unit
`10 2 checks again if the respiration is stable. This shows that
`until the patient falls asleep the PM value will not be
`superior to the treatment pressure PT, and will only equals it
`when the patient falls asleep or when the safety ramp reaches
`the treatment pressure value. This also shows that during the
`15 ramp period, if the respiration is stable, the air provided
`can rise faster than the safety ramp.. In that case, the
`coefficient KRP will be higher than the coefficient Ksp. The
`ramp module will thus enable to the control unit to accelerate
`the rise in pressure when the patients fall asleep and when no
`20 events are detected.
`An other implementation of the apparatus according to the
`present invention is that when the control unit detects an an
`event in patients breathing that shows an asleep state , the
`control unit will provide the ramp module 10 with the
`25 information. The ramp module will thus increase again the rise
`in pressure.
`The following are examples of ramp periods generated by
`the apparatus according the present invention.
`
`30
`
`Example 1: Variations of value PM according to different
`
`events
`Figure 2 represents one example of the apparatus
`functioning wherein three systems of coordinates are
`represented : pressure value PM as a function of time,
`35 patient's breathing B as a function of time and snoring S as a
`function of time. At a time ts, the ramp module 10 activates
`
`ResMed Inc. Exhibit 1034
`Page 8 of 16
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`7
`
`the rise in pressure. At time t1 as a slowdown E1 in breathing
`
`is detected, the rise in pressure is accelerated by the ramp
`module 10. Then at time t2 snoring E2 is detected. Thus, the
`rise in pressure is accelerated again by the ramp module. As
`
`5 at time t3 a snoring E3 is still detected the ramp module
`
`still accelerates the rise in pressure. As represented on
`
`figure 2, the preferred embodiment is a linear rise in
`
`pressure. Thus at time ts, the coefficient KRP of rise in
`
`pressure is constant. Each time an event is detected the
`
`10 module ramp adds a given constant value KE to this
`
`coefficient, the slope of the linear function being thus
`
`accentuated at each event. This will last until the treatment
`
`pressure PT is raised. Then the ramp is completed and the
`
`control unit applies the treatment pressure to the patient's
`
`15 mask. The value KE can be set by the physician in a non
`
`volatile memory and can be different according to the event
`
`detected.
`
`Example 2 : Example of calculating the value PM
`
`20
`
`In this example the treatment pressure PT is of 10 hecto
`
`pascal (hPa). The initial pressure Po of the air provided at
`
`patient's mask is 4 hPa. A physician has set that the ramp
`
`will start at a time ts of 2 minutes and has set the initial
`
`coefficient KRP at 0.2 hPa per minute (hPa/mn). The physician
`
`25 also set that when a snoring is detected KE equals 1 hPa when
`
`the breath rate is below a set threshold.
`
`When the apparatus starts the control units supply the
`
`blower in order to set at the patient's mask a pressure of 4
`
`hPa. After 2 minutes, the ramp module starts increasing the
`
`30 value PM. As no events occurs, the coefficient KRP stays at 0.2
`
`hPa. After 10 minutes the value PM is of 5.6 hPa (8 minutes
`
`multiplied by 0.2 hPa/mn and added to the 4 hPa). After these
`
`ten minutes, the patient's breath is below threshold. The ramp
`
`module adds the corresponding KE value to the coefficient 'CRT,
`35 which thus equals 1.2 hPa/mn. The treatment pressure is thus
`
`raised in about 13 minutes and 40 seconds.
`
`ResMed Inc. Exhibit 1034
`Page 9 of 16
`
`

`

`WO 03/075991
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`PCT/IB03/01422
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`8
`
`CLAIMS
`
`1. An apparatus (1) to assist a patient respiration by
`delivering air to a patient trough a mask (20), comprising :
`5 - a blower (4) to provide the patient with air under a
`treatment pressure,
`- a control unit (2) to adjust the pressure delivered by said
`blower at the level of said mask,
`- a ramp module (10) connected to the control unit in order to
`10 provide the control unit with the value of pressure PM to
`settle at said mask, so that when said apparatus starts
`functioning, the pressure progressively rises until the
`pressure of treatment PT;
`characterized in that it comprises a comparator connected to
`15 the ramp module, at least one means for detecting the
`patient's breathing parameters and sending them to said
`comparator, in order in response to said breathing parameters,
`that the comparator is able to determine that an event (E1, E2
`or E3) occurs in patient's breathing and to send the
`20 corresponding data to the ramp module which provides the
`control unit with a value of pressure PM that will speed up
`with respect of time, so that the rise of pressure at
`patient's mask is accelerated.
`
`25
`
`2. The apparatus (1) according to claim 1, wherein said
`ramp module provides the value of pressure PM being a linear
`function of time wherein the increase coefficient KRP is
`constant, said ramp module increasing that coefficient of a
`constant value KE when the control unit (2) send a data
`30 corresponding to said event (E1, E2 or E3).
`
`3. The apparatus according claim 1 or 2, wherein the
`value of pressure PM has always maximum and/or minimum limits
`
`so that the increase of pressure is also limited in minimum
`35 and/or maximum.
`
`ResMed Inc. Exhibit 1034
`Page 10 of 16
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`

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`9
`
`4. The apparatus according claim 2 and 3, wherein said
`ramp module (10) comprises a memory (12) where a minimum
`coefficient KgRp is stored, said ramp module always maintaining
`the coefficient KRp equal or superior to said minimum
`5 coefficient Ksgp, so that the ramp module provides the control
`unit (2) with a value of pressure PM always superior to a
`minimum limit.
`
`5. The apparatus (1) according to claim 2 and 3, wherein
`10 said ramp module (10) comprises a memory (12) where a maximum
`coefficient Kmiu, is stored, said ramp module always maintaining
`the coefficient KRp equal or inferior to said maximum
`coefficient KMRP, so that the ramp module provides the control
`unit (2) with a value of pressure PM always inferior to a
`15 maximum limit.
`
`6. The apparatus according to any of the previous
`claims, wherein said means (6) for detecting the patient's
`breathing parameters enable the control unit (2) to compute
`20 the airflow at patient's mask (20), said comparator
`determining that an event (EI,
`E2 or E3) is occurring with the
`
`airflow parameters or shape.
`
`7. The apparatus according to any one of the previous
`25 claims, wherein the ramp module (10) increases the value of
`pressure PM when an anomaly, such as snoring or apnea, in
`patient's breathing is detected.
`
`8. The apparatus according to any one of the previous
`30 claims, wherein the ramp module (10) increases the value of
`pressure PM when the patient's breathing parameters correspond
`to a drop between awake breathing and asleep breathing or when
`they correspond to a stable frequency of breathing.
`
`ResMed Inc. Exhibit 1034
`Page 11 of 16
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`1 /2
`
`6
`
`41b
`
`8
`
`20
`
`4
`
`FIG. 1
`
`PM
`PT
`
`Po
`
`B
`
`S
`
`1
`
`E2
`
`is
`
`t2 t3
`
`FIG. 2
`
`10
`
`12
`
`2
`
`t
`
`t
`
`ResMed Inc. Exhibit 1034
`Page 12 of 16
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`2/2
`
`Pm
`
`P
`
`0
`
`02
`
`tT
`
`FIG. 3
`
`(START)
`
`Pm = Po
`
`YES
`
`Pm = Pm + KRp X dt
`
`RESPIRATION
`STABLE
`?
`
`NO
`
`PM < SRP
`
`NO
`
`YES
`
`PM = SRP
` I
`
`PM> PT
`
`NO
`
`PM = PT
`it
`( END
`
`FIG. 4
`
`ResMed Inc. Exhibit 1034
`Page 13 of 16
`
`

`

`INTERNATIONAL SEARCH REPORT
`
`Inte
`rnal Application No
`PCT/IB 03/01422
`
`A. CLA7SSIFIC
`ATION OF SUBJECT MATTER
`IPC
`A61M16/00
`
`According to International Patent Classification (IPC) or to both national classification and IPC
`B. FIELDS SEARCHED
`Minimum documentation searched (classification system followed by classification symbols)
`A61M
`IPC 7
`
`:
`
`Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched
`
`Electronic data base consulted during the International search (name of data base and, where practical, search terms used)
`EPO -Internal
`
`C. DOCUMENTS CONSIDERED TO BE RELEVANT
`Category ° Citation of document, with indication, where appropriate, of the relevant passages
`
`X
`
`A
`
`US 5 970 975 A (ESTES MARK C ET AL)
`26 October 1999 (1999-10-26)
`cited in the application
`column 1, line 13 - line 22
`column 6, line 62 - line 65
`column 18, line 57 -column 19, line 29
`column 21, line 53 -column 23, line 20
`column 23, line 54 -column 24, line 46
`column 24, line 62 -column 28, line 41
`claims 2-5; figures 1,2,5 -6,8A -8C,10 -13
`
`US 5 245 995 A (LYNCH CHRISTOPHER ET AL)
`21 September 1993 (1993-09-21)
`column 2, line 56 - line 61
`column 5, line 22 - line 34
`column 6, line 54 -column 7, line 61
`
`Relevant to claim No.
`
`1-8
`
`1-8
`
`documents are listed in the continuation of box C.
`Further
`X
`° Special categories of cited documents:
`A' document defining the general state of the art which is not
`considered to be of particular relevance
`'E' earlier document but published on or after the international
`filing date
`'L' document which may throw doubts on priority claim(s) or
`which is cited to establish the publication date of another
`citation or other special reason (as specified)
`'0' document referring to an oral disclosure, use, exhibition or
`other means
`'P' document published prior to the international filing date but
`later than the priority date claimed
`Date of the actual completion of the international search
`
`16 June 2003
`Name and mailing address of the ISA
`European Patent Office, P.B. 5818 Patentlaan 2
`NL - 2280 HV Rijswijk
`Tel. (+31-70) 340-2040, Tx. 31 651 epo ni,
`Fax: (+31-70) 340-3016
`
`Form POT/ISA/210 (second sheet) (July 1902)
`
`X
`
`
`
`members are listed in annex. Patent family
`
`'T' later document published after the international filing date
`or priority date and not in conflict with the application but
`cited to understand the principle or theory underlying the
`invention
`'X' document of particular relevance; the claimed invention
`cannot be considered novel or cannot be considered to
`involve an inventive step when the document Is taken alone
`'Y' document of particular relevance; the claimed invention
`cannot be considered to involve an Inventive step when the
`document is combined with one or more other such docu-
`ments, such combination being obvious to a person skilled
`in the art.
`8,' document member of the same patent family
`Date of mailing of the international search report
`
`03/07/2003
`Authorized officer
`
`Borowski A
`
`page 1 of 2
`
`ResMed Inc. Exhibit 1034
`Page 14 of 16
`
`

`

`INTERNATIONAL-SEARCH REPORT
`
`C.(Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT
`
`IntE
`al Application No
`PCT/IB 03/01422
`
`Category ° Citation of document, with indication,where appropriate, of the relevant passages
`
`Relevant to claim No.
`
`A
`
`US 5 503 146 A (FROEHLICH JAMES P ET AL)
`2 April 1996 (1996-04-02)
`column 1, line 6-10
`column 1, line 54 -column 2, line 14
`column 2, line 34 - line 65
`column 3, line 52 -column 5, line 40
`claims 1,2; figures 1,2
`
`1-8
`
`Form PCT/15A210 (continuation of second sheet) (July 1992)
`
`page 2 of 2
`
`ResMed Inc. Exhibit 1034
`Page 15 of 16
`
`

`

`INTERNATIONAL SEARCH REPORT
`
`Intel _ nal Application No
`PCT/IB 03/01422
`
`Patent document
`cited in search report
`
`Publication
`date
`
`Patent family
`member(s)
`
`US 5970975
`
`A
`
`26-10-1999
`
`US 5245995
`
`A
`
`21-09-1993
`
`US 5503146
`
`A
`
`02-04-1996
`
`US
`US
`US
`US
`US
`AT
`AU
`AU
`CA
`DE
`DE
`EP
`US
`WO
`US
`US
`
`US
`US
`US
`US
`US
`US
`
`AU
`AU
`BR
`CA
`El'
`
`5551418 A
`5239995 A
`5901704 A
`5904141 A
`,5823187 A
`188619 T
`660340 B2
`2926892 A
`2122590 Al
`69230564 D1
`69230564 T2
`0610405 Al
`6427689 B1
`9308857 Al
`5492113 A
`RE35295 E
`
`2002124848 Al
`2002100477 Al
`6398739 B1
`5522382 A
`5199424 A
`2002007127 Al
`
`689641 B2
`3435495 A
`9504560 A
`2160509 Al
`0709107 Al
`
`Publication
`date
`
`03-09-1996
`31-08-1993
`11-05-1999
`18-05-1999
`20-10-1998
`15-01-2000
`22-06-1995
`07-06-1993
`13-05-1993
`17-02-2000
`31-08-2000
`17-08-1994
`06-08-2002
`13-05-1993
`20-02-1996
`16-07-1996
`
`12-09-2002
`01-08-2002
`04-06-2002
`04-06-1996
`06-04-1993
`17-01-2002
`
`02-04-1998
`09-05-1996
`25-02-1997
`27-04-1996
`01-05-1996
`
`Form PCT/ISA/210 (patent family annex) (July 1502)
`
`ResMed Inc. Exhibit 1034
`Page 16 of 16
`
`