www.archive.org
`415.561.6767
`415.840-0391 e-fax
`
`Internet Archive
`300 Funston Avenue
`San Francisco, CA 94118
`_____________________
`
`DECLARATION OF NATHANIEL E FRANK-WHITE
`
`1.
`
`I am a Records Request Processor at the Internet Archive. I make this declaration
`of my own personal knowledge.
`
`2. The Internet Archive is a website that provides access to a digital library of Internet
`sites and other cultural artifacts in digital form. Like a paper library, we provide
`free access to researchers, historians, scholars, and the general public. The Internet
`Archive has partnered with and receives support from various institutions,
`including the Library of Congress.
`
`3. The Internet Archive has created a service known as the Wayback Machine. The
`Wayback Machine makes it possible to browse more than 450 billion pages stored
`in the Internet Archive's web archive. Visitors to the Wayback Machine can search
`archives by URL (i.e., a website address). If archived records for a URL are
`available, the visitor will be presented with a display of available dates. The visitor
`may select one of those dates, and begin browsing an archived version of the Web.
`Links on archived files in the Wayback Machine point to other archived files
`(whether HTML pages or other file types), if any are found for the URL indicated
`by a given link. For instance, the Wayback Machine is designed such that when a
`visitor clicks on a hyperlink on an archived page that points to another URL, the
`visitor will be served the archived file found for the hyperlink’s URL with the
`closest available date to the initial file containing the hyperlink.
`
`4. The archived data made viewable and browseable by the Wayback Machine is
`obtained by use of web archiving software that automatically stores copies of files
`available via the Internet, each file preserved as it existed at a particular point in
`time.
`
`5. The Internet Archive assigns a URL on its site to the archived files in the format
`http://web.archive.org/web/[Year in yyyy][Month in mm][Day in dd][Time code in
`hh:mm:ss]/[Archived URL] aka an “extended URL”. Thus, the extended URL
`http://web.archive.org/web/19970126045828/http://www.archive.org/ would be the
`URL for the record of the Internet Archive home page HTML file
`(http://www.archive.org/) archived on January 26, 1997 at 4:58 a.m. and 28
`seconds (1997/01/26 at 04:58:28). The date indicated by an extended URL applies
`to a preserved instance of a file for a given URL, but not necessarily to any other
`files linked therein. Thus, in the case of a page constituted by a primary HTML file
`and other separate files (e.g., files with images, audio, multimedia, design
`elements, or other embedded content) linked within that primary HTML file, the
`primary HTML file and the other files will each have their own respective extended
`URLs and may not have been archived on the same dates.
`
`6. Attached hereto as Exhibit A are true and accurate copies of screenshots of the
`Internet Archive's records of the archived files for the URLs and the dates specified
`in the attached coversheet of each printout.
`
`Miltenyi Ex. 1024 Page 1
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`

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`7.
`
`I declare under penalty of perjury under the laws of the United States of America
`that the foregoing is true and correct.
`
`Feb 22, 2022
`DATE: ________________________
`
`________________________
`Nathaniel E Frank-White
`
`Miltenyi Ex. 1024 Page 2
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`
`
`
`
`
`EXHIBIT A
`EXHIBIT A
`
`Miltenyi Ex. 1024 Page 3
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`Miltenyi Ex. 1024 Page 3
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`

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`https://web.archive.org/web/20081118174453/http:/blocks.fhcrc.org/sift/SIFT.html
`
`Miltenyi Ex. 1024 Page 4
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`"" " " '" , •," Jhitp://bloeks.fhorc.org/sift/SIFT.html
`WIUU9ekffiOO~in~ 6 captures
`
`15N0.-2008 :U !111201'
`
`I
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`I 11 I
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`~ OCT
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`JAN
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`◄
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`2007
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`►
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`I I ! 2015
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`El (i) 0
`1] 0
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`Sorting I ntolerant From T olerant
`
`at the Fred Hutchinson Cancer Research Center.
`Brought to you by the Blocks WWW server.
`
`SIFT predicts wh.,ther ,m amino acid substitution atlects protein function based on sequence homology ,md the physical properli..s of amino acids. SITT can b" applied to naturally
`occurring 11011synonymous polymotphisms and laboratory-induced missense llltt1atio11s.
`
`Given a protein sequence. SITT will retum predictions for what amino acid substitutions will affect protein function.
`
`SIFT is a multistep procc-dure that:
`(I) searches for and chooses similar sequences
`(2) makes an alignment of these sequences
`(3) calculates scores based on the amino acids appearing at each position in the alignment.
`
`You can:
`submit a dbSNP id (SNPs from multiple proleins. 2 mi.nules)
`-or- submit a GI /± ('.' minutes)
`-or- s11bmi1 lLP-rotein sequence (10- 15 minutes)
`-or- submit a quen• sequence along with relntcd sequences (< I minute)
`-or- submit !iligiunent ofY.our ,iuerY. se,iuence with related se,iuenccs (< 1 minute)
`-or submit a block
`
`SIFT for in-house use (version 3.0, released March 2 1, 2008):
`Copyyi1!11l code & exe (Sun, Linuxl RepJlflbu2s
`
`Prediclion on humnn SNPs (Genome Research 12: 436-446 P.dl)
`I11i1ial training/test sets for SIFT: Lacl. 1,Y.son'.me, !IlV nrotease
`
`Oiher prediction tools for amino acid s11bstinitions: PolY.Phen , MAPP . SNPs,\12, P.Mut
`Many prediction 10o!s haw been dew,/oped since SIFT 11•as firs, published ii 2001. MAPP, SNPs3D. and P.Mut are tlu·ee me1hods !hat have been shown to petform better !ban SIFT
`in their published results.
`- SNPs3D is great for fast retrieval of predictions of nsSNPs from dbSNP
`- MAPP is great if you only have one or two proteins to predict on
`
`Our review "Predicting the Effects of Amino Acitl Subslilutions on Protein Function" in A111111nl Rel'iew o/Genomics and Human Genelics:
`Char.1er
`Supplemenlary Table I
`Citation
`
`Referencing SIFT
`version I (Rdfl. version 2 (Rdfl
`
`SIFThelr-.P-!!gl:
`Aboul 1he author
`
`Page last modified January 2007
`Q11esrio,1s or comments?
`Co111ac1 m.
`
`Miltenyi Ex. 1024 Page 5
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`