January 25, 1993
`
`VOLUME 268
`
`NUMBER 3
`
`ISSN 0021-9258
`JBCHA3 268(3) 1501-2268 (1993)
`
`THE
`ourna o
`
`•
`
`•
`
`•
`
`IO 0
`
`ICO
`em1s r
`
`Published by the American Society for Biochemistry
`and Molecular Biology
`
`FOUNDED BY CHRISTIAN A HERlER
`
`ANO SUSTAINED IN PART BY THE CHR I STIAN A HERTER MEMORIAL FUND
`
`Miltenyi Ex. 1036 Page 1
`
`

`

`THE JOURNAL OF BIOLOGICAL CHEMISTRY
`
`FOUNDED BY CHRISTIAN A. HERTER AND SUSTAINED IN PART BY THE CHRISTIAN A. HERTER MEMORIAL FUND
`
`PUBLISHED BY THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC.
`
`EDITORIAL BOARD/1993
`
`Herbert Tabor, Editor
`Ralph A. Bradshaw, Associafrl ijdiWG R /CU LTU
`I. Robert Lehman, Associate Editor
`RA L
`John H. Exton, Associate Editor
`Jerry B Lingrel, Associate Editor
`I
`Quentin H. Gibson, Associate Editor I BR ARY
`Alton Meister, Associate Editor
`Alan G. Goodridge, Associate Editor
`Stephen M. Prescott, Associate Editor
`Richard W. Hanson, Associate fE,Sr f
`1991l
`Robert T. Schimke, Associate Editor
`.J
`Robert L. Hill, Associate Editor
`Robert D. Simoni, Associate Editor
`C. H. W. Hirs, Associatf!~/';rJ,it;,gr_
`Kensal E. van Holde, Associate Editor
`Edward D. Korn, Asso't'it'itWit:dlit&-/ TY OF r AL I FO
`Edwin G. Krebs, Associate Edito'R I VER S /0 E R /\JI A
`Martha Vaughan, Associate Editor
`
`Jules A. Shafer
`Thomas L. lnnerarity
`Robert Deschenes
`Angus C. Nairn
`William S. Allison
`Joel H. Shaper
`Neil M. Nathanson
`Paul A. lnsel
`Murray P. Deutscher
`Paul M. Anderson
`Ravi Iyengar
`Stephen B. Shears
`Michael E. Nesheim
`J. Fred Dice
`Mario Ascoli
`Susan ,Jaken
`Thomas J. Silhavy
`Richard R. Neubig
`Jack E. Dixon
`Joseph Avruch
`S. Stoney Simons
`Christopher B. Newgard
`Leonard S. Jefferson
`Michael G. Douglas
`Bernard M. Babior
`Eric F. Johnson
`William Dowhan
`Randal A. Skidgel
`J. Wylie Nichols
`Jacques U. Baenziger
`Suresh K. Joseph
`Carolyn W. Slayman
`Timothy W. Nilsen
`George R. Dubyak
`Robert A. Bambara
`Donald M. Small
`John H. Nilson
`Laurie S. Kaguni
`Peter A. Edwards
`Heinz Baumann
`Jerrold M. Olefsky
`Joseph A. Beavo
`William L. Smith
`Joseph Katz
`Duane C. Eichler
`Alan D. Elbein
`Martin D. Snider
`Eric N. Olson
`Randal Kaufman
`William T. Beck
`Arthur A. Spector
`Merle S. Olson
`Y oshito Kaziro
`Marshall Elzinga
`Vann Bennett
`Thomas J. Kelly, Jr.
`Allen M. Spiegel
`Jeffrey D. Esko
`Steven T. Olson
`Dale J. Be nos
`Robert G. Kemp
`Charles T. Esmon
`Linda L. Spremulli
`Charles P. Ordahl
`Merton Bernfield
`Byron Kemper
`E. Richard Stanley
`Mulchand S. Patel
`Alexandre Fabiato
`Kenneth I. Berns
`Peter H. Fishman
`Stephen M. Beverley
`James V. Staros
`Michael S. Kilberg
`John T. Penniston
`Donald F. Steiner
`Roger M. Perlmutter
`Randall L. Kincaid
`Frank A. Fitzpatrick
`Michael Blackburn
`Howard M. Steinman
`David G. Klapper
`Suzanne R. Pfeffer
`Michael Forgac
`Perry J. Blackshear
`Michael D. Pierschbacher Paul C. Sternweis
`Joseph S. Krakow
`Kenneth M. Blumenthal Minoru Fukuda
`Richard L. Stevens
`Linda J. Pike
`Thomas A. Kunkel
`David L. Garbers
`Stephen Bocckino
`James W. Bodley
`Gary L. Stiles
`Paul F. Pilch
`Michael M. C. Lai
`Robert L. Geahlen
`Gary M. Bokoch
`Jeffry B. Stock
`Simon J. Pilkis
`J. David Lambeth
`Marvin C. Gershengorn
`Bryce V. Plapp
`Daniel R. Storm
`Y. C. Lee
`Donald L. Gill
`Mark Bothwell
`JoAnne Stubbe
`Jonathan Leis
`Reid Gilmore
`Susan Powers-Lee
`Barry J. Bowman
`Mark H. Ginsberg
`Richard L. Proia
`James T. Stull
`Warren J. Leonard
`Alan R. Brash
`Kathleen J. Sweadner
`John D. Lipscomb
`Alexander N. Glazer
`Christian R. H. Raetz
`David L. Brautigan
`Howard S. Tager
`Martin C. Rechsteiner
`Claiborne V. C. Glover III Darrell T. Liu
`Joan Heller Brown
`John P. Reeves
`Alan R. Tall
`Mark 0. Lively
`Irwin J. Goldstein
`George J. Broze
`Marvin L. Tanzer
`Timothy M. Lohman
`Myron F. Goodman
`Sue Goo Rhee
`Joseph Bryan
`Jeffrey I. Gordon
`John M. Taylor
`Robert E. Rhoads
`Peter M. J. Burgers
`Martin G. Low
`Daryl K. Granner
`John B. Lowe
`Palmer Taylor
`John P. Richardson
`Kevin P. Campbell
`Jeffrey Robbins
`Kenneth A. Thomas
`Donald J. Graves
`Kenneth L. Luskey
`John R. Cann
`Owen W. Griffith
`Larry S. Tobacman
`Philip W. Majerus
`Anita B. Roberts
`Roderick A. Capaldi
`Douglas M. Tollefsen
`Janet D. Robishaw
`Richard W. Gross
`Gerald M. Carlson
`Craig C. Malbon
`George M. Carman
`Howard C. Towle
`Thomas E. Roche
`Lawrence Grossman
`James L. Maller
`Paul R. Rosevear
`James Travis
`Lorraine J. Gudas
`Peter C. Maloney
`John E. Casnellie
`F. Peter Guengerich
`James M. Manning
`Richard A. Roth
`Robert B. Trimble
`Kevin Catt
`Lucia B. Rothman-Denes
`Frederic A. Troy II
`Thomas F. J. Martin
`Gordon Hager
`William A. Catterall
`Harry T. Haigler
`Roger Y. Tsien
`Marino Martinez-Carrion Harry Roy
`Richard A. Cerione
`Sen-itiroh Hakomori
`Joan Massague
`Salvatore J. Turco
`Lawrence Chan
`Peter Rubenstein
`Yusuf A. Hannun
`Kathleen S. Matthews
`David W. Russell
`Axel Ullrich
`Moses V. Chao
`Robert A. Harris
`Richard A. Maurer
`Richard B. Vallee
`John C. Saari
`William W. Chin
`Gerald W. Hart
`J. Denis McGarry
`Dennis E. Vance
`J. Evan Sadler
`P. Boon Chock
`Frederick C. Hartman
`Thomas M. McIntyre
`,Joseph J. Villafranca
`Lawrence E. Samelson
`Frank C. Church
`G. Wesley Hatfield
`G. Stanley McKnight
`David Samols
`Dennis R. Voelker
`Mary Sue Coleman
`Gerhard Meissner
`Charles E. Samuel
`B. Moseley Waite
`Gary B. Henderson
`J. D. Corbin
`John L. Wang
`Susan A. Henry
`John P. Merlie
`Carl Schildkraut
`Michael M. Cox
`Alfred H. Merrill, Jr.
`Michael R. Waterman
`Mark A. Hermodson
`Verne Schirch
`Richard L. Cross
`Harvey R. Herschman
`Paul H. Weigel
`Dennis D. Cunningham
`Richard J. Miller
`Keith K. Schlender
`John W. B. Hershey
`Keith Moffat
`Robert D. Schreiber
`William W. Wells
`Norman P. Curthoys
`Ronald W. Holz
`William T. Morgan
`Nancy B. Schwartz
`Morris F. White
`Michael E. Dahmus
`M. Marlene Hosey
`Dale W. Mosbaugh
`Larry W. Daniel
`James P. Whitlock, Jr.
`James R. Sellers
`Billy G. Hudson
`Savio L. C. Woo
`Deane F. Mosher
`Ganes C. Sen
`Roger J. Davis
`James B. Hurley
`Joel Moss
`Henry C. Wu
`Alan E. Senior
`Glyn Dawson
`Tadashi lnagami
`Marc Mumby
`David Ray Setzer
`Howard Zalkin
`Edward A. Dennis
`
`John T. Edsall, Advisor to the Board
`Charles C. Hancock, Manager, 9650 Rockville Pike, Bethesda, Maryland 20814
`
`Miltenyi Ex. 1036 Page 2
`
`

`

`Vol. 268, No. 3
`
`The Journal of
`Biological Chemistry
`
`Copyright © 1993 by the American Society for Biochemistry and Molecular Biology, Inc.
`428 East Preston St., Baltimore, MD 21202 U.S.A.
`
`CONTENTS*
`
`January 25, 1993
`
`MINIREVIEW
`1501 The MARCKS family of cellular protein kinase C sub(cid:173)
`strates. Perry J. Blackshear
`
`COMMUNICATIONS
`1505 Promoter activity of human renin 5'-flanking DNA
`sequences is activated by the pituitary-specific tran(cid:173)
`scription factor Pit-_l. Jidong Sun, Carole Oddoux, Amy
`Lazarus, Matthew T. Gilbert, and Daniel F. Catanzaro
`
`1509 Cloning and expression of a mammalian Na+ /amino acid
`cotransporter with sequence similarity to Na+/glucose
`cotransporters. Cheng-Te Kong, Shaw-Fang Yet, and Julia
`E. Lever
`
`1513 Disruption of potential sites for N-linked glycosylation
`does not impair hormone binding to the lutropin/cho(cid:173)
`riogonadotropin receptor if Asn-173 is left intact.
`Xuebo Liu, David Davis, and Deborah L. Segala//
`
`1517 Small heat shock proteins are molecular chaperones.
`Ursula Jakob, Matthias Gaestel, Katrin Engel, and Johannes
`Buchner
`
`1521 The biological relevance of the binding of calcium ions
`by inositol phosphates. Brian M. Luttrell
`
`1580 Growth factors that repress myoblast differentiation
`sustain phosphorylation of a specific site on histone H 1.
`Francesca Cole, Thomas M. Fasy, Sunkara S. Rao, Mary Anne
`de Peralta, and D. Stave Kohtz
`1586 Histamine induces a gene-specific synthesis regulation
`of secretogranin II but not of chromogranin A and B in
`chromaffin cells in a calcium-dependent manner. Jo(cid:173)
`hann W. Bauer, Rudolf Kirchmair, Claudia Egger and Reiner
`Fischer-Colbrie
`'
`1590 Mutations of the molecular chaperone protein SecB
`which alter the interaction between SecB and maltose(cid:173)
`binding protein. Pamela M. Gannon and Carol A. Kumamoto
`1596 The number of amphipathic a-helical segments of apo(cid:173)
`lipoproteins A-1, E, and A-IV determines the size and
`functional properties of their reconstituted lipoprotein
`particles. Ana Jonas, Armin Steinmetz, and Lisa Churgay
`1603 Chemical modification of bacteriophage T4 deoxynu(cid:173)
`cleotide kinase. Evidence of a single catalytic region.
`George S. Brush and Maurice J. Bessman
`1610 Effects of intracellular amino acid concentrations
`cyclic AMP, and dexamethasone on lysosomal proteol~
`ysis in primary cultures of perinatal rat hepatocytes.
`Pietjan J. E. Blommaart, Duca Zonneveld, Alfred J. Meijer,
`and Wouter H. Lamers
`1618 a- and ~-xylosides alter glycolipid synthesis in human
`melanoma and Chinese hamster ovary cells. Hudson H.
`Freeze, Deepak Sampath, and Ajit Varki
`1628 Identification of vicinal thiols of phosphoenolpyruvate
`carboxykinase (GTP). Cristina T. Lewis, Jerome M. Seyer,
`Robert G. Cassell, and Gerald M. Carlson
`Horseradish peroxidase-catalyzed two-electron oxida(cid:173)
`tions. Oxidation of iodide, thioanisoles, and phenols at
`distinct sites. Robert Z. Harris, Sherri L. Newmyer and Paul
`R. Ortiz de Montellano
`'
`The Streptococcus sanguis platelet aggregation-asso(cid:173)
`ciated protein. Identification and characterization of
`the minimal platelet-interactive domain. Pamela R. Er(cid:173)
`ickson and Mark C. Herzberg
`Repair of individual DNA strands in the hamster di(cid:173)
`hydrofolate reductase gene after treatment with ultra(cid:173)
`violet light, alkylating agents, and cisplatin. Alfred May
`Rodney S. Nairn, Diane S. Okumoto, Karsten Wassermann'
`Tinna Stevnsner, Jennifer C. Jones, and Vilhelm A. Bohr
`'
`1658 Phycobilins of cryptophycean algae. Novel linkage of
`dihydrobiliverdin in a phycoerythrin 555 and a phy(cid:173)
`cocyanin 645. David E. Wemmer, Gary J. Wedemayer, and
`Alexander N. Glazer
`1670 Uptake of high density lipoprotein cholesterol ester by
`HepG2 cells involves apolipoprotein E localized on the
`cell surface. Lorraine Leblond and Yves L. Marcel
`Isozyme-specific modules on human aldolase A mole(cid:173)
`cule. Isozyme group-specific sequences 1 and 4 are
`required for showing characteristics as aldolase A. Ki(cid:173)
`yohisa Motoki, Yoshihiko Kitajima, and Katsuji Hori
`1575 Genetic and immunological analyses of the cyanobac(cid:173)
`1684 Precise location of the Cu(II)-inhibitory binding site in
`terium Synechocystis sp. PCC 6803 show that the pro(cid:173)
`tein encoded by the psbJ gene regulates the number of
`higher plant and bacterial photosynthetic reaction cen(cid:173)
`photosystem II centers in thylakoid membranes. Lisbet
`ters as probed by light-induced absorption changes.
`K. Lind, Vipula K. Shukla, Karin J. Nyhus, and Himadri B.
`Im1:aculada Yruela, Miguel Alfonso, Iiiaki Ortiz de Zarate,
`Pakrasi
`Guillermo Montoya, and Rafael Picorel
`* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS.
`Full Instructions to Authors will be found in (1993) J. Biol. Chem. 268, 745-753, and reprints may be obtained from the editorial office.
`iii
`
`ARTICLES
`1525 Conformational, thermodynamic, and stability prop(cid:173)
`erties of Manduca sexta apolipophorin III. Robert 0.
`Ryan, Kim Oikawa, and Cyr~l M. Kay
`
`1531 Evidence that energization of the chloroplast ATP syn(cid:173)
`thase favors ATP formation at the tight binding cata(cid:173)
`lytic site and increases the affinity for ADP at another
`catalytic site. Jun-Mei Zhou and Paul D. Boyer
`
`1539 Studies on the mechanism of oxidative phosphoryla(cid:173)
`tion. Different effects of F o inhibitors on unisite and
`multisite ATP hydrolysis by bovine submitochondrial
`particles. Akemi Matsuno-Yagi and Youssef Hatefi
`
`1546 Evidence for specific base catalysis in N-dealkylation
`reactions catalyzed by cytochrome P450 and chloro(cid:173)
`peroxidase. Differences in rates of deprotonation of
`aminium radicals as an explanation for high kinetic
`hydrogen isotope effects observed with peroxidases.
`Osamu Okazaki and F. Peter Guengerich
`
`1553 pH-dependent stability and membrane interaction of
`the pore-forming domain of colicin A. Arturo Muga, Juan
`M. Gonzalez-Manas, Jeremy H. Lakey, Franc Pattus and
`Witold K. Surewicz
`'
`
`1558 Slow binding of ATP to noncatalytic nucleotide binding
`sites which accelerates catalysis is responsible for ap(cid:173)
`parent negative cooperativity exhibited by the bovine
`mitochondrial F 1-ATPase. Jean-Michel Jault and William
`S. Allison
`
`1567 Cell penetration of diphtheria toxin. Reduction of the
`interchain disulfide bridge is the rate-limiting step of
`tra~slocation in ~he cytosol. Emanuele Papini, Rina Rap(cid:173)
`puoh, Marta Murgia, and Cesare Montecucco
`
`1637
`
`1646
`
`1650
`
`1677
`
`Miltenyi Ex. 1036 Page 3
`
`

`

`1690 Cooperative phenomena in binding and activation of
`Bordetella pertussis adenylate cyclase by calmodulin.
`Ahmed Bouhss, Evelyne Krin, Helene Munier, Anne-Marie
`Gilles, Antoine Danchin, Philippe Glaser, and Octavian Barzu
`
`1695 Characterization of a synthetic calmodulin-binding
`peptide derived from Bacillus anthracis adenylate cy(cid:173)
`clase. Helene Munier, Francisco J. Blanco, Benedicte Pre(cid:173)
`cheur, Eric Diesis, Jose L. Nieto, Constantin T. Craescu, and
`Octavian Barzu
`
`1702 Purification and characterization of membrane-bound
`chitin synthase. Sachiko Machida and Michihiko Saito
`
`1708 Mechanism of reaction of fatty acid hydroperoxides
`with soybean peroxygenase. Elizabeth Blee, Allan L. Wil(cid:173)
`cox, Lawrence J. Marnett, and Francis Schuber
`
`1716 Influenza hemagglutinin-mediated membrane fusion
`does not involve inverted phase lipid intermediates.
`Toon Stegmann
`
`1723 A luteinizing hormone receptor with a severely trun(cid:173)
`cated cytoplasmic tail (LHR-ct628) desensitizes to the
`same degree as the full-length receptor. Xi Zhu, Thomas
`Gudermann, Mariel Birnbaumer, and Lutz Birnbaumer
`
`1729 Physiological role of NhaB, a specific Na+;H+ anti(cid:173)
`porter in Escherichia coli. Elhanan Pinner, Yaniv Kotler,
`Etana Padan, and Shimon Schuldiner
`
`1735 Hydrolysis of short acyl chain inositol lipids by phos(cid:173)
`pholipase C-o1 • Mario J. Rebecchi, Robert Eberhardt, Tracy
`Delaney, Shaukat Ali, and Robert Bittman
`
`1742 Cumulative effect of double-site mutations of human
`epidermal growth factor on receptor binding. Stephen
`R. Campion, Mary K. Geck, and Salil K. Niyogi
`
`1749 Ca2+-dependent and Ca2+-independent isozymes of pro(cid:173)
`tein kinase C mediate exocytosis in antigen-stimulated
`rat basophilic RBL-2H3 cells. Reconstitution of secre(cid:173)
`tory responses with Ca2+ and purified isozymes in
`washed permeabilized cells. Koichiro Ozawa, Zoltan Szal(cid:173)
`lasi, Marcelo G. Kazanietz, Peter M. Blumberg, Harald Mis(cid:173)
`chak, J. Frederic Mushinski, and Michael A. Beaven
`
`1757 An N-terminal glycosylation signal on cytochrome
`P450 is restricted to the endoplasmic reticulum in a
`luminal orientation. Elzbieta Szczesna-Skorupa and Byron
`Kemper
`
`1763 The prohormone convertases PC 1 and PC2 mediate
`distinct endoproteolytic cleavages in a strict temporal
`order during proopiomelanocortin biosynthetic proc(cid:173)
`essing. An Zhou, Brian T. Bloomquist, and Richard E. Mains
`
`1770 Insulinomimetic effect on glucose transport by epider(cid:173)
`mal growth factor when combined with a major histo(cid:173)
`compatibility complex class I-derived peptide. Jan
`Stagsted, S0ren Ziebe, Shinobu Satoh, Geoffrey D. Holman,
`Samuel W. Cushman, and Lennart Olsson
`
`1775 Direct analysis of the binding of the abl Src homology
`2 domain to the activated epidermal growth factor
`receptor. Guochang Zhu, Stuart J. Decker, Bruce J. Mayer,
`and Alan R. Saltiel
`
`1780
`
`Isolation and properties of adenovirus type 2 protein(cid:173)
`ase. Karoly Tihanyi, Martin Bourbonniere, Alain Houde, Clau(cid:173)
`dine Rancourt, and Joseph M. Weber
`
`1786 Differential regulation of adenylylcyclases in vegeta(cid:173)
`tive and gametic flagella of chlamydomonas. Yuhua
`Zhang and William J. Snell
`
`1792 Topology of P-glycoprotein as determined by epitope
`mapping ofMRK-16 monoclonal antibody. Elias Georges,
`Takashi Tsuruo, and Victor Ling
`
`1799 A second groEL-like gene, organized in a groESL op(cid:173)
`eron is present in the genome of Synechocystis sp. PCC
`6803. Csaba Lehel, Dmitry Los, Hajime Wada, Janos Gyor(cid:173)
`gyei, Ibolya Horvath, Eszter Kovacs, Norio Murata, and Laszlo
`Vigh
`
`V
`
`1805 Binding of DNA quenches tyrosine fluorescence of
`RecA without energy transfer to DNA bases. Svante
`Eriksson, Bengt Norden, and Masayuki Takahashi
`
`1811 Role of tyrosine residue 264 of RecA for the binding of
`cofactor and DNA. Svante Eriksson, Bengt Norden, Katsumi
`Morimatsu, Toshihiro Horii, and Masayuki Takahashi
`1817 Removal of stable tyrosine radical D+ affects the struc(cid:173)
`ture or redox properties of tyrosine Z in manganese(cid:173)
`depleted photosystem II particles from Synechocystis
`6803. Renee J. Boerner, Kathryn A. Bixby, Anh P. Nguyen,
`George H. Noren, Richard J. Debus, and Bridgette A. Barry
`1824 Cloning and sequencing of a cDN A encoding Saccha(cid:173)
`romyces cerevisiae carnitine acetyltransferase. Use of
`the cDN A in gene disruption studies. Gyula Kispal, Balazs
`Sumegi, Klaus Dietmeier, Ildiko Bock, Gabriella Gajdos, Ti(cid:173)
`hamer Tomcsanyi, and Attila Sandor
`1830 Cold adaptations in Drosophila. Qualitative changes of
`triacylglycerols with relation to overwintering. Takashi
`Ohtsu, Chihiro Katagiri, Masahito T. Kimura, and Samuel H.
`Hori
`
`1835 Cloning and functional expression in yeast of two hu(cid:173)
`man isoforms of the outer mitochondrial membrane
`channel, the voltage-dependent anion channel. Elizabeth
`Blachly-Dyson, E. Brygida Zambronicz, Wei Hong Yu, Volker
`Adams, Edward R. B. McCabe, John Adelman, Marco Colom(cid:173)
`bini, and Michael Forte
`
`1842 Pteridine biosynthesis in human endothelial cells. Im(cid:173)
`pact on nitric oxide-mediated formation of cyclic GMP.
`Gabriele Werner-Felmayer, Ernst R. Werner, Dietmar Fuchs,
`Arno Hausen, Gilbert Reibnegger, Kurt Schmidt, Gunter Weiss,
`and Helmut Wachter
`
`"
`
`1847 The structural motif glycine 190-valine 202 of the
`fibrinogen 'Y chain interacts with CD1 lb/CD18 integrin
`(o:Mf32 , Mac-1) and promotes leukocyte adhesion. Dario
`C. Altieri, Janet Plescia, and Edward F. Plow
`
`1854 The glucocorticoid receptor and a putative repressor
`protein coordinately modulate glucocorticoid respon(cid:173)
`siveness of the mouse mammary tumor virus promoter
`in the rat hepatoma cell line Ml.19. Hirotoshi Tanaka,
`Yu Dong, Jacqueline M,,cGuire, Sam Okret, Lorenz Poellinger,
`Isao Makino, and Jan-Ake Gustafsson
`1860 Polypeptide composition of the a-latrotoxin receptor.
`High affinity binding protein consists of a family of
`related high molecular weight polypeptides complexed
`to a low molecular weight protein. Alexander G. Petrenko,
`Victoria D. Lazaryeva, Martin Geppert, Tatyana A. Tarasyuk,
`Carolyn Moomaw, Andrei V. Khokhlatchev, Yuri A. Ushkar(cid:173)
`yov, Clive Slaughter, Igor V. Nasimov, and Thomas C. Sudhof
`
`1868 Translational regulation of mitochondrial differentia(cid:173)
`tion in neonatal rat liver. Specific increase in the trans(cid:173)
`lational efficiency of the nuclear-encoded mitochon(cid:173)
`drial p'-F 1-ATPase mRNA. Ana M. Luis, Jose M. Izquierdo,
`Luciana K. Ostronoff, Matilde Salinas, Juan F. Santaren, and
`Jose M. Cuezva
`
`1876 Control of protein traffic between distinct plasma mem(cid:173)
`brane domains. Requirement for a novel 108,000 pro(cid:173)
`tein in the fusion of transcytotic vesicles with the apical
`plasma membrane. Elizabeth Sztul, Maria Colombo, Philip
`Stahl, and Reba Samanta
`1886 Cross-competition for binding of 0:1 -anti trypsin (o: 1
`AT)-elastase complexes to the serpin-enzyme complex
`receptor by other serpin-enzyme complexes and by pro(cid:173)
`teolytically modified o:1 AT. Gregg Joslin, Art Wittwer,
`Steve Adams, Douglas M. Tollefsen, Anna August, and David
`H. Perlmutter
`
`1894 Cloning of a novel surface antigen from the insect
`stages of Trypanosoma brucei by expression in COS
`cells. David G. Jackson, Dean K. Smith, Colin Luo, and John
`F. Elliott
`
`1901 ATP induces a conformational change of the 90-kDa
`heat shock protein (hsp90). Peter Csermely, Judit Kajtar,
`Miklos Hollosi, George Jalsovszky, Sandor Holly, C. Ronald
`Kahn, Peter Gergely, Jr., Csaba Soti, Katalin Mihaly, and Janos
`Somogyi
`
`The Journal of Biological Chemistry (ISSN 0021-9258) is published three times per month by the American Society for Biochemistry and Molecular Biology, Inc., 428 East Preston Street,
`Baltimore, MD 21202, U.S.A. Volume 268 for 1993: United States, $710; other countries, $860. Single copy: United States, $24.00; other countries, $28.00. Special subscription rates are
`available to members, graduate students, and postdoctoral fellows for personal use only. Qualifying forms are available from the ASBMB Office, 9650 Rockville Pike, Bethesda, MD 20814.
`Second class postage paid at Baltimore, MD 21202, U.S.A. and at additional mailing offices. Send address changes to The Journal of Biological Chemistry at 428 East Preston Street,
`Baltimore, MD 21202, U.S.A.
`
`Miltenyi Ex. 1036 Page 4
`
`

`

`vi
`
`1931
`
`1921
`
`1908 Expression of the nitric oxide synthase gene in mouse
`macrophages activated for tumor cell killing. Molecu(cid:173)
`lar basis for the synergy between interferon--y and
`lipopolysaccharide. Robert B. Lorsbach, William J. Murphy,
`Charles J. Lowenstein, Solomon H. Snyder, and Stephen W.
`Russell
`1914 Coupling of cytosolic protein synthesis and mitochon(cid:173)
`drial protein import in yeast. Evidence for cotransla(cid:173)
`tional import in vivo. Masaaki Fujiki and Keith Verner
`Activating and inhibitory mutations in the regulatory
`domain of CheB, the methylesterase in bacterial chemo(cid:173)
`taxis. Richard C. Stewart
`DNA repair by eukaryotic nucleotide excision nuclease.
`Removal of thymine dimer and psoralen monoadduct
`by HeLa cell-free extract and of thymine dimer by
`Xenopus laevis oocytes. Daniel L. Svoboda, John-Stephen
`Taylor, John E. Hearst, and Aziz Sancar
`/ 1937 Sequence analysis of lens ,8-crystallins suggests in(cid:173)
`volvement of calpain in cataract formation. Larry L.
`David, Thomas R. Shearer, and Marjorie Shih
`1941 The motif Tyr-X-X-hydrophobic residue mediates ly(cid:173)
`sosomal membrane targeting of lysosome-associated
`membrane protein 1. Frank G. Guarnieri, Linda M. Arter(cid:173)
`burn, Margaret B. Penno, Ying Cha, and J. Thomas August
`194 7 Binding of the RN A polymerase I transcription com(cid:173)
`plex to its promoter can modify positioning of down(cid:173)
`stream nucleosomes assembled in vitro. Philippe Georgel,
`Borries Demeter, Chris Terpening, Marvin R. Paule, and Ken(cid:173)
`sal E. van H olde
`1955 Point mutagenesis of carboxyl-terminal amino acids of
`cholesteryl ester transfer protein. Opposite faces of an
`amphipathic helix important for cholesteryl ester
`transfer or for binding neutralizing antibody. Suke
`Wang, Xingbo Wang, Liping Deng, Eric Rassart, Ross W.
`Milne, and Alan R. Tall
`1960 Phosphorylation and activation of a high molecular
`weight form of phospholipase A2 by p42 microtubule(cid:173)
`associated protein 2 kinase and protein kinase C. Ra(cid:173)
`phael A. Nemenoff, Sim Winitz, Nan-Xin Qian, Vicki Van
`Putten, Gary L. Johnson, and Lynn E. Heasley
`1965 Characterization of a DNA polymerase from the hy(cid:173)
`perthermophile archaea Thermococcus litoralis. Vent
`DNA polymerase, steady state kinetics, thermal stab!l(cid:173)
`ity, processivity, strand displacement, and exonuclease
`activities. Huimin Kong, Rebecca B. Kucera, and William E.
`Jack
`factor/transforming
`1976 A 40-kDa epidermal growth
`growth factor a-binding domain produced by limited
`proteolysis of the extracellular domain of the epidermal
`growth factor receptor. Daisuke Kohda, Masafumi Odaka,
`Irit Lax, Hiroshi Kawasaki, Koichi Suzuki, Axel Ullrich, Joseph
`Schlessinger, and Fuyuhiko Inagaki
`1982 A myristoylated pseudosubstrate peptide, a novel pro(cid:173)
`tein kinase C inhibitor. Thomas Eichholtz, Dries B. A. de
`Bont, John de Widt, Rob M. J. Liskamp, and Hidde L. Ploegh
`1987 Angiotensin II regulates parathyroid hormone-related
`protein expression in cultured rat aortic smooth muscle
`cells through transcriptional and post-transcriptional
`mechanisms. Carlos J. Pirola, Hai-mei Wang, Amin Kamyar,
`Siaoxing Wu, Hiro Enomoto, Behrooz Sharifi, James S. Forres(cid:173)
`ter, Thomas L. Clemens, and James A. Fagin
`1995 Enhancement by protein kinase C of prostacyclin
`receptor-mediated activation of adenylate cyclase
`through a calmodulin/myristoylated alanine-rich C ki(cid:173)
`nase substrate (MARCKS) system in IC2 mast cells.
`Tohru Sawai, Manabu Negishi, Nobuhiro Nishigaki, Tadao
`Ohno, and Atsushi Ichikawa
`2001 Role of endoplasmic reticular calcium in oligosaccha(cid:173)
`ride processing of ai-antitrypsin. Galina Kuznetsov, Mar(cid:173)
`garet A. Brostrom, and Charles 0. Brostrom
`2009 Proteolytic processing of human amyloid ,8 protein pre(cid:173)
`cursor in insect cells. Major carboxyl-terminal frag(cid:173)
`ment is identical to its human counterpart. Triprayar V.
`Ramabhadran, Samuel E. Gandy, Jorge Ghiso, Andrew J. Czer(cid:173)
`nik, David Ferris, Ramaninder Bhasin, Dmitry Goldgaber, Blas
`Frangione, and Paul Greengard
`
`2048
`
`2013 Evidence for an extended structure of the T-cell co(cid:173)
`receptor CDBa as deduced from the hydrodynamic
`properties of soluble forms of the extracellular region.
`Jean Philippe Boursier, Andres Alcover, Frederique Herve,
`Isabelle Laisney, and Oreste Acuto
`2021 The D domain of the thyroid hormone receptor a 1
`specifies positive and negative transcriptional regula(cid:173)
`tion functions. Youngsook Lee and Vijak Mahdavi
`2029 Changes in the structure and catalytic activities of the
`bovine pituitary multicatalytic proteinase complex fol(cid:173)
`lowing dialysis. Bo Yu, Maria E. Pereira, and Sherwin Wilk
`2037 Regulation of the cystic fibrosis transmembrane con(cid:173)
`ductance regulator c1- channel by specific protein
`kinases and protein phosphatases. Herbert A. Berger, Sue
`M. Travis, and Michael J. Welsh
`Identification of the herpes simplex virus-1 protease
`cleavage sites by direct sequence analysis of autopro(cid:173)
`teolytic cleavage products. Carolyn L. Dilanni, Diana A.
`Drier, Ingrid C. Deckman, Patrick J. McCann III, Fenyong
`Liu, Bernard Roizman, Richard J. Colonna, and Michael G.
`Cordingley
`2052 Molecular characterization and expression of the Dro(cid:173)
`sophila Ca2+/calmodulin-dependent protein kinase II
`gene. Identification of four forms of the enzyme
`generated from a single gene by alternative splicing.
`Shunji Ohsako, Yasuyoshi Nishida, Haruko Ryo, and Takashi
`Yamauchi
`2063 Aspartyl residue 10 is essential for ATPase activity of
`rat hsc70. Shiao-ping Huang, Ming- Ying Tsai, Ywh-Min
`Tzou, Wen-guey Wu, and Chung Wang
`2069 Degradation of entactin by matrix metalloproteinases.
`Susceptibility to matrilysin and identification of cleav(cid:173)
`age sites. Ulrike I. Sires, Gail L. Griffin, Thomas J. Broekel(cid:173)
`mann, Robert P. Mecham, Gillian Murphy, Albert E. Chung,
`Howard G. Welgus, and Robert M. Senior
`2075 Expression of Drosophila Rrpl protein in Escherichia
`coli. Enzymatic and physical characterization of the
`intact protein and a carboxyl-terminally deleted exo(cid:173)
`nuclease-deficient mutant. Miriam Sander, Meryl Carter,
`and Shu-Mei Huang
`2083 The rat liver ecto-ATPase is also a canalicular bile acid
`transport protein. C. Jeffrey Sippel, Frederick J. Suchy, M.
`Ananthanarayanan, and David H. Perlmutter
`2092 Novel 8-base pair sequence (Drosophila DNA replica(cid:173)
`tion-related element) and specific binding factor in(cid:173)
`volved in the expression of Drosophila genes for DNA
`polymerase a and proliferating cell nuclear antigen.
`Fumiko Hirose, Masamitsu Yamaguchi, Hiroshi Handa, Yukio
`Inomata, and Akio Matsukage
`2100 Accumulation of 1,2-sn-diradylglycerol with increased
`membrane-associated protein kinase C may be the
`mechanism for spontaneous hepatocarcinogenesis in
`choline-deficient rats. Kerry-Ann da Costa, Elizabeth F.
`Cochary, Jan K. Blusztajn, Sanford C. Garner, and Steven H.
`Zeise[
`2106 Molecular characterization of four pharmacologically
`distinct a-aminobutyric acid transporters in mouse
`brain. Qing-Rong Liu, Beatriz Lopez-Corcuera, Sreekala Man(cid:173)
`diyan, Hannah Nelson, and Nathan Nelson
`2113 Site-directed mutagenesis of HIV-1 integrase demon(cid:173)
`strates differential effects on integrase functions in
`vitro. Andrew D. Leavitt, Lily Shiue, and Harold E. Varmus
`2120 Structure, organization, and chromosomal mapping of
`the human macrophage scavenger receptor gene. Mit(cid:173)
`suru Emi, Hitoshi Asaoka, Akiyo Matsumoto, Hiroshige Itak(cid:173)
`ura, Yukiko Kurihara, Yoichiro Wada, Hiroshi Kanamori,
`Yoshio Yazaki, Ei-ichi Takahashi, Mark Lepert, Jean-Marc
`Lalouel, Tatsuhiko Kodama, and Tsunehiro Mukai
`2126 Charged collagen structure mediates the recognition of
`negatively charged macromolecules by macrophage
`scavenger receptors. Takefumi Doi, Ken-ichi Higashino,
`Yukiko Kurihara, Yoichiro Wada, Tohru Miyazaki, Haruki
`Nakamura, Seiichi Uesugi, Takeshi Imanishi, Yoshiki Kawabe,
`Hiroshige Itakura, Yoshio Yazaki, Akiyo Matsumoto, and Tat(cid:173)
`suhiko Kodama
`2134 Recombinant human tumor necrosis factor a induces
`calcium oscillation and calcium-activated chloride cur(cid:173)
`rent in human neutrophils. The role of calcium/calmod(cid:173)
`ulin-dependent protein kinase. Muhammad A. Schumann,
`Phyllis Gardner, and Thomas A. Ra/fin
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`2141
`
`Inactivation of a redox-sensitive protein phosphatase
`during the early events of tumor necrosis factor/inter(cid:173)
`leukin-I signal transduction. Graeme R. Guy, Jennifer
`Cairns, Siew Bee Ng, and Y. H. Tan
`2149 Direct association of interleukin-6 with a 130-kDa
`component of the interleukin-6 receptor system. Fran(cid:173)
`cesco D'Alessandro, Oscar R. Colamonici, and Richard P.
`Nordan
`2154 Regulation of human tissue factor expression by mRNA
`turnover. Shawn M. Ahern, Toshiyuki Miyata, and J. Evan
`Sadler
`2160 Molecular cloning and identification of a point muta(cid:173)
`tion in the topoisomerase II cDNA from an etoposide(cid:173)
`resistant Chinese hamster ovary cell line. Victor T. W.
`Chan, Shu-wing Ng, J. Paul Eder, and Lowell E. Schnipper
`2166 Nascent RNA cleavage by purified ternary complexes
`of vaccinia RN A polymerase. Jeremiah Hagler and Stewart
`Shuman
`2174 Guanylyl cyclase C is an N-linked glycoprotein recep(cid:173)
`tor that accounts for multiple heat-stable enterotoxin(cid:173)
`binding proteins in the intestine. Arie B. Vaandrager,
`Stephanie Schulz, Hugo R. De Jonge, and David L. Garbers
`2180 Activation of the human vimentin gene by the Tax
`human T-cell leukemia virus I. Mechanisms of regula(cid:173)
`tion by the NF -KB transcription factor. Alain Lilienbaum
`and Denise Paulin
`2189 A pathogen-responsive gene of parsley encodes tyro(cid:173)
`sine decarboxylase. Petra Kawalleck, Harald Keller, Klaus
`Hahlbrock, Dierk Scheel, and Imre E. Somssich
`2195 Dominant lethal mutations near the 5' substrate bind(cid:173)
`ing site affect RNA polymerase propagation. Valery Sag(cid:173)
`itov, Vadim Nikiforov, and Alex Goldfarb
`2203 Stimulation of poly(A) tail elongation by the VP39
`subunit of the vaccinia virus-encoded poly(A) polym(cid:173)
`erase. Paul David Gershon and Bernard Moss
`2211 Selection of a mutant cell line based on differential
`expression of glycosphingolipid, utilizing anti-lactosyl(cid:173)
`ceramide antibody and complement. Tsutomu Tsuruoka,
`Tsutomu Tsuji, Hisao Nojiri, Eric H. Holmes, and Sen-itiroh
`Hakomori
`
`vii
`
`2217 Regulatory role of GM3 ganglioside in cx5.Bl integrin
`receptor for fibronectin-mediated adhesion of FUA169
`cells. Mingzhe Zheng, Hang Fang, Tsutomu Tsuruoka, Tsu(cid:173)
`tomu Tsuji, Tomikazu Sasaki, and Sen-itiroh Hakomori
`2223 Structural and functional changes of lysosomal acid cx(cid:173)
`glucosidase during intracellular transport and matu(cid:173)
`ration. Heleen A. Wisselaar, Marian A. Kroos, Monique M.
`P. Hermans, Jos van Beeumen, and Arnold J. J. Reuser
`2232 Dissection of the biotinyl subunit of transcarboxylase
`into regions essential for activity and assembly. B. C.
`Shenoy, Ganesh K. Kumar, and David Samols
`2239 Hydrodynamic properties and immunological identifi(cid:173)
`cation of the sodium- and chloride-coupled glycine
`transporter. Beatriz Lopez-Corcuera, Rafael Alcantara, Jesus
`Vazqu