` -554 ^u Pda =iane_]j Ok_eapu bkn >ek_daieopnu ]j` Ikha_qh]n >ekhkcu( Ej_*
`
`Rkh* .3/( Jk* -3( Eooqa kb =lneh .0( ll* -,/,4 ®-,/-.( -554
`9NGKPCB GK =%;%,%
`
`8KOFPFRBHU 1E>NDBA 9BOFAQBO >P 8KOFPFKJO &'" &," >JA &- KC
`3HQ@>DKJ 2JOQNB 6>TFIQI 0FKHKDF@>H 8KPBJ@U!
`
`$Na_aera` bkn lq^he_]pekj( Jkrai^an 3( -553( ]j` ej nareoa` bkni( Ba^nq]nu -/( -554%
`
`1B@FHF> 3$ <JOKJW" 1QF#9KJD =Q" 1KJJFB 8$ 1EBQJD" >JA 9$ 0$ 6BNNFCFBHA
`
`1NLJ PFC :LAHCDCIICN =KGRCNOGPU# 7CS >LNH# 7CS >LNH '&&('
`
`3HQ@>DKJ FO > LBLPFAB EKNIKJB PE>P LH>UO > @BJPN>H
`NKHB FJ PEB I>FJPBJ>J@B KC JKNI>H @FN@QH>PFJD DHQ@KOB
`HBRBHO$ :PNQ@PQNB#>@PFRFPU OPQAFBO E>RB LNBRFKQOHU ABI#
`KJOPN>PBA PEB FILKNP>J@B KC EFOPFAFJB >P LKOFPFKJ & >JA
`PEB >?OKHQPB NBMQFNBIBJP CKN >OL>NPF@ >@FA >P LKOFPFKJ .
`CKN PN>JOAQ@PFKJ KC PEB EKNIKJ>H OFDJ>H$ :FPB#AFNB@PBA
`64
`IQP>DBJBOFO KC PEB NB@BLPKN LNKPBFJ FABJPFCFBA /OL KJ
`PEB BTPN>@BHHQH>N 7#PBNIFJ>H P>FH PK ?B @NQ@F>H CKN PEB
`NB@KDJFPFKJ CQJ@PFKJ KC PEB NB@BLPKN$ 4J >AAFPFKJ" >JPF#
`?KAFBO DBJBN>PBA >D>FJOP >OL>NPF@ >@FA#NF@E BLFPKLBO
`CNKI PEB BTPN>@BHHQH>N NBDFKJ @KILBPBA BCCB@PFRBHU SFPE
`DHQ@>DKJ CKN NB@BLPKN OFPBO" SEF@E OQDDBOPBA PE>P JBD>#
`PFRB @E>NDBO I>U HFJB PEB LQP>PFRB DHQ@>DKJ ?FJAFJD
`LK@GBP FJ PEB NB@BLPKN$ ;EBOB K?OBNR>PFKJO HBA PK PEB
`FAB> PE>P LKOFPFRBHU @E>NDBA NBOFAQBO KJ PEB EKNIKJB
`I>U >@P >O @KQJPBNFKJO PK PEBOB OFPBO$ 0>OBA KJ PEBOB
`FJFPF>H CFJAFJDO" SB OUJPEBOFVBA DHQ@>DKJ >J>HKDO FJ
`SEF@E ?>OF@ NBOFAQBO >P LKOFPFKJO &'" &," >JA &- SBNB
`NBLH>@BA SFPE JBQPN>H KN >@FAF@ NBOFAQBO PK BT>IFJB PEB
`BCCB@P KC >HPBNFJD PEB LKOFPFRB @E>NDB KJ PEKOB OFPBO KJ
`?FJAFJD >JA >ABJUHUH @U@H>OB >@PFRFPU$
`;EB NBOQHPO FJAF@>PB PE>P QJHFGB 7#PBNIFJ>H EFOPFAFJB"
`12
`17
`18
`5UO " /ND " >JA /ND
`KC DHQ@>DKJ E>RB RBNU H>NDB BC#
`CB@PO KJ NB@BLPKN ?FJAFJD >JA PN>JOAQ@PFKJ KC PEB EKN#
`IKJ>H OFDJ>H" >HPEKQDE PEBU >NB JKP >?OKHQPBHU @NFPF@>H$
`;EBU @KJPNF?QPB OPNKJDHU PK PEB OP>?FHFV>PFKJ KC PEB ?FJA#
`FJD FJPBN>@PFKJ SFPE PEB DHQ@>DKJ NB@BLPKN PE>P HB>AO PK
`I>TFIQI ?FKHKDF@>H LKPBJ@U$
`
`Chq_]ckj eo ] lkhulalpe`a dknikja pd]p _kjoeopo kb .5 ]iejk
`]_e` naoe`qao ]j` eo ] iai^an kb ] decdhu dkikhkckqo b]iehu kb
`^ekhkce_]hhu ]_pera lalpe`ao* Oa_napa` ^u l]j_na]pe_ = _ahho( epo
`lnei]nu p]ncap knc]j eo pda heran sdana( pkcapdan sepd ejoqhej(
`ep lh]uo ] _ajpn]h nkha ej pda i]ejpaj]j_a kb jkni]h _en_qh]pejc
`chq_koa haraho _nepe_]h pk pda oqnrer]h kb pda knc]jeoi* Pda
`ejepe]h arajp ej chq_]ckj ]_pekj eo ^ej`ejc pk epo na_alpkn kj pda
`oqnb]_a kb heran _ahho* Pda ^ej`ejc iaoo]ca _kjopepqpao pda oec)
`j]h pd]p eo pn]joieppa` ]_nkoo pda iai^n]ja pk cq]jeja jq_ha)
`kpe`a ^ej`ejc lnkpaej)hejga` ejpn]_ahhqh]n abba_pkno pd]p ]na qh)
`pei]pahu naolkjoe^ha bkn chq_koa lnk`q_pekj*
`Pda chq_]ckj na_alpkn eo ] iai^an kb ] qjemqa ^n]j_d kb pda
`C lnkpaej)_kqlha` na_alpkn oqlanb]iehu pd]p d]o decdhu dkikh)
`kckqo oamqaj_ao ^qp od]nao ranu bas kb pda _kjoanra` opnq_)
`pqn]h ba]pqnao bkqj` sepdej pda naop kb pda C lnkpaej)_kqlha`
`
`& Pdeo skng s]o oqllknpa` ^u Q* O* Lq^he_ Da]hpd Oanre_a Cn]jp @G
`.0,/5* = lnaheiej]nu nalknp kb l]np kb pdeo skng s]o lnaoajpa` ]p pda
`-1pd =iane_]j Lalpe`a Ouilkoeqi( Fqja -0 ®-5( -553( J]odrehha( PJ*
`Pda _kopo kb lq^he_]pekj kb pdeo ]npe_ha sana `abn]ua` ej l]np ^u pda
`l]uiajp kb l]ca _d]ncao* Pdeo ]npe_ha iqop pdanabkna ^a dana^u i]nga`
`§?BRCNPGOCJCKP· ej ]__kn`]j_a sepd -4 Q*O*?* Oa_pekj -3/0 okhahu pk
`ej`e_]pa pdeo b]_p*
`° Pk sdki _knnaolkj`aj_a odkqh` ^a ]``naooa`6 Pda Nk_gabahhan Qje)
`ranoepu( -./, Ukng =ra*( Jas Ukng( Jas Ukng -,,.-* Pah*6 .-.)/.3)
`4./57 B]t6 .-.)/.3)4.01*
`
`na_alpkn b]iehu $-( .%* Iai^ano kb pdeo na_alpkn cnkql ej_hq`a
`na_alpkno bkn pda chq_]ckj b]iehu kb dknikjao( chq_]ckj)hega
`1
`lalpe`a - $CHL)-%
`$/%( oa_napej $0%( c]opnej ejde^epknu lalpe`a
`$1%( ]j` r]ok]_pera ejpaopej]h lalpe`a $2%* Pda na_alpkn d]o ]
`nah]perahu h]nca atpn]_ahhqh]n J paniejqo pdkqcdp pk ^a ej)
`rkhra` ej dknikja)na_alpkn ejpan]_pekj( bkhhksa` ^u du`nkldk)
`^e_ dahe_]h oaciajpo lkopqh]pa` pk ol]j pda iai^n]ja oaraj
`peiao ]j` ] _upklh]oie_ ?)paniej]h `ki]ej $Bec* -%* Oecj]h
`pn]jo`q_pekj eo pdkqcdp pk lnk_aa` qlkj ^ej`ejc kb pda dknikja
`sepd pda atpn]_ahhqh]n nacekj kb pda na_alpkn* Pda ia_d]jeoi
`^u sde_d pda oecj]h eo _kjraua` bnki pda _ahh oqnb]_a ]_nkoo pda
`pn]joiai^n]ja dahe_]h japskng pk ]_per]pa C lnkpaej)_kqlha`
`abba_pkno kj pda oqnb]_a kb _upklh]oi eo jkp qj`anopkk`*
`Atpajoera opnq_pqna)bqj_pekj opq`eao kb chq_]ckj d]ra ]b)
`bkn`a` okia ejoecdp ejpk pda qj`anop]j`ejc kb epo ia_d]jeoi kb
`]_pekj* Pda cajan]h le_pqna pd]p d]o aianca` eo pd]p pda ]_pera
`ld]ni]_kldkna eo `eolanoa` pdnkqcdkqp pda chq_]ckj ikha_qha
`]j` pd]p pda ejp]_p dknikja eo ja_aoo]nu bkn pda atlnaooekj kb
`bqhh dknikj]h ]_perepu* Jaranpdahaoo( ola_ebe_ ]_pera oepa naoe)
``qao naolkjoe^ha bkn aepdan decd ]bbejepu ^ej`ejc kn ]_per]pekj
`d]ra ^aaj oejcha` kqp* Aha_pnkop]pe_ ejpan]_pekjo kb pda jac])
`perahu _d]nca` oe`a _d]ej kb ]ol]npe_ ]_e` 5( -1( ]j` .- sana
`odksj pk ^a aooajpe]h ej chq_]ckj bqj_pekj $3( 4%* =_perepu s]o
`9
`hkop sdaj =ol s]o `ahapa` kn nalh]_a` ^u ]ju kpdan ]iejk
`]_e`*
`=j eilknp]jp a]nhu bej`ejc bnki lekjaanejc opnq_pqna)]_per)
`epu opq`eao aop]^heoda` pd]p pda J)paniej]h deope`eja sde_d eo
`opne_phu _kjoanra` sepdej pda chq_]ckj lalpe`a b]iehu s]o ao)
`oajpe]h bkn na_alpkn ]_per]pekj ]j` haoo ok bkn ^ej`ejc ]j` ei)
`lhea` pd]p pda `ahapekj kb deope`eja skqh` lnk`q_a ] chq_]ckj
`]jp]ckjeop $5%* Ej`aa`( pda benop l]npe]h ]jp]ckjeopo pd]p sana
`1
``arahkla` sana `ao)Deo `aner]perao kn chq_]ckj ]j]hkco pd]p
`d]` ik`ebea` deope`ejao ]p pda J paniejqo $-, ®--%* Bqnpdan
`opq`eao `aikjopn]pa` pd]p pda eie`]vkha nejc kb deope`eja ]p
`lkoepekj kja kb pda dknikja bqnjeodao `apaniej]jpo bkn ^kpd
`na_alpkn ^ej`ejc ]bbejepu ]j` ]_perepu $-.%*
`Oaneja naoe`qao ]p lkoepekjo .( 4( ]j` -2 sana ]hok odksj pk
`lh]u lnkiejajp nkhao ej chq_]ckj ]_pekj $-/%* Pda ]ll]najp
`9
`16
`_kjja_pekj kb Deo ( =ol ( ]j` Oan
`naoe`qao ha` pk pda dulkpd)
`aoeo pd]p ] _]p]hupe_ pne]` naoai^hejc pd]p kb ] oaneja lnkpa)
`]oa iecdp ^a ejrkhra` ej pda ia_d]jeoi kb chq_]ckj oecj]h
`pn]jo`q_pekj $-/%*
`Pda chq_]ckj ^ej`ejc _]repu kj pda na_alpkn eo ikop hegahu ]
``eo_kjpejqkqo `ki]ej pd]p ejrkhrao _kjpne^qpekjo bnki pda hkjc
`J)paniej]h atpajoekj ]o sahh ]o bnki pda pdnaa atpn]_ahhqh]n
`hkklo pd]p _kjja_p pda oaraj pn]joiai^n]ja dahe_ao $-0%* Ej)
`bkni]pekj ]^kqp pda _kilhaiajp]nu lalpe`a ]j` lnkpaej ejpan)
`]_pekjo pd]p `e_p]pa pda ^ej`ejc ldajkiajkj eo _ajpn]h pk pda
``aoecj kb ]jp]ckjeopo kb pda dknikja pd]p iecdp ^a _heje_]hhu
`nahar]jp* Pk ejraopec]pa pda ikha_qh]n ia_d]jeoi kb dknikja)
`na_alpkn ejpan]_pekj ]j` kb na_alpkn ]_per]pekj ^u oepa)`ena_pa`
`
`Pda ]^^nare]pekj qoa` eo6 CHL)-( chq_]ckj)hega lalpe`a -*
`
`-,/,4
`
`$*+2 0%0(1 +2 %4%+-%&-( /. -+.( %3 *330#""555!,&'!/1)
`
`This is an Open Access article under the CC BY license.
`
`MYLAN EXHIBIT - 1015
`Mylan Pharmaceuticals, Inc. v. Bausch Health Ireland, Ltd. - IPR2022-00722
`
`
`
`2IQA?ELK ;PNQAPQNC ?KB 1QKAPGLK
`
`-,/,5
`
`PALL T OL Hc P YL L
`L
`*
`L LSL NHHCODSyLKWK E F LF DMv0AS pA K PLCSL V V L L
`50
`P
`P P T EL VC*N RTFC(;(' Y4 SCWP DT P p*NT TAN I SC PWYL PWYHK
`/ 0"-Klia_vs i E003MOCOSADRWSOGR PGRV WOGDpsC,R, JKFVL R VH°
`(xr
`,,,; A8 A ,,,acw N.GF
`\._s.A-y.c.,_„,
`
`T 03C3 W
`SN
`W
`
`y
`
`\G SvNi ,,,3/
`y s
`vW
`I
`1.a, E
`K 0
`0
`Sy
`V Y KIR L
`V T yG
`WL
`! vs' v
`S sL
`GL L A A G
`L A L v L sR
`
`e
`R
`V
`T A
`l ase
`Y,
` 0
`.,,NA
`
`C L L W
`EV
`
`E
`.
`. ,
``c
`K
`V V
`VP,,
`L F;3L
`G.S w
`i vL C
`
`
`
`GT L Rs .,,,,,
`a
`T
`A
`K
`k R
`PL
`_.
`F
`CA' F DoFFLF:v:s
`V
`V :v v
`LL p
`
`Extracellular
`
`L
`
`RP'
`VA L L
`I - , L
`NIF F
`F , RV
`
`BEC* -* :@EBI>PF@ NBLNBOBJP>PFKJ KC
`PEB N>P DHQ@>DKJ NB@BLPKN LNFI>NU
`>JA OB@KJA>NU OPNQ@PQNB$ Oaraj lqp])
`pera pn]joiai^n]ja dahe_ao ^]oa` kj lna)
`rekqo ik`aho kb C lnkpaej)_kqlha` na_al)
`pkno ]na odksj* Pda J paniejqo ]j`
`atpn]_ahhqh]n oqnb]_a eo pks]n` pda PLM(
`]j` pda ? paniejqo ]j` _upklh]oie_ oqn)
`b]_a eo pks]n` pda @LPPLJ kb pda becqna*
`=ol ( sde_d s]o opq`ea` ^u oepa)ola_ebe_
`eo KQJ@CNCB ]j` h]^aha`
`iqp]cajaoeo(
`sepd ]j ?NNLS $-1%* Pda hk_]pekjo kb oa)
`mqaj_ao bnki pda atpn]_ahhqh]n `ki]ej
`pd]p sana qoa` ]o pda lalpe`ao bkn ]jpe)
`na_alpkn ]jpe)lalpe`a ]jpe^k`u lnk`q_pekj
`]na @LTCB*
`
`
`
`F AL
`VtL I
`0 GIN
`:
`H
`
`R
`
`
`
`'' LrIcTRNY
`
`L F S
`V GL T
` _ zs Y ..... _I F
`
`L H'
`
` _ R.L.L. „Ay. , . , , —.S T, il
`
`L I LT
`
`A
`E
`H A
`Lsi T TFS.0 OmH y AD y KF RI-
`
`11:‘;CY
`N
`K
`E
`V
`0
`R W R R
`AELLR
`
`Intracellular
`
`GA SML OL KEC PDGH CT GA PA MHS GHSSAMREEOLA KG
`
`0 42n
`
`E
`
`SGTGCE PS AKT SL AS SL PR LADS PT
`
`iqp]cajaoeo( sa d]ra oujpdaoeva` ] caja bkn pda n]p chq_]ckj
`na_alpkn $-1( -2%*
`Pda a]nheaop ejbkni]pekj pk _kia bnki oepa)`ena_pa` iqp]caj)
`64
`ej pda
`aoeo kb pda chq_]ckj na_alpkn lnkpaej e`ajpebea` =ol
`atpn]_ahhqh]n J)paniej]h p]eh pk ^a ]^okhqpahu namqena` bkn pda
`na_kcjepekj bqj_pekj kb pda na_alpkn $-1%* Na_ajp opq`eao d]ra
`]hok eilhe_]pa` ]na]o ej pda iai^n]ja lnktei]h lknpekj kb pda
`J paniejqo ]j` pda benop atpn]_ahhqh]n hkkl pk ^a l]np kb pda
`dknikja ^ej`ejc oepa $-3%* Ikna eilknp]jphu( ]jpe^k`eao n]eoa`
`]c]ejop lalpe`ao nalnaoajpejc oamqaj_ao bnki pdaoa nacekjo
`sana ejde^epkno kb chq_]ckj ^ej`ejc pk pda na_alpkn $-4%* Pdaoa
`lalpe`a alepklao _kjp]eja` _hqopano kb jac]perahu _d]nca` naoe)
``qao( sde_d oqccaopa` pd]p ]j aha_pnkop]pe_ ]ook_e]pekj sepd ]
`_kilhaiajp]nu lkoeperahu _d]nca` naoe`qa kj pda hec]j` iecdp
`k__qn ]p pdaoa na_alpkn oepao*
`Pk paop pdeo lkooe^ehepu( sa ]ooaooa` pda _kjpne^qpekj kb pda
`lkoeperahu _d]nca` cnkqlo ]p lkoepekjo -.( -3( ]j` -4( pk chq_])
`ckj na_alpkn na_kcjepekj( sde_d pk `]pa d]o jkp ^aaj _ha]nhu
`aop]^heoda`* Sa oujpdaoeva` chq_]ckj ]j]hkco _kjp]ejejc oq^)
`18
`kb chq_]ckj sepd jaqpn]h kn
`12
`17
`opepqpekjo kb Huo ( =nc ( ]j` =nc
`jac]perahu _d]nca` naoe`qao pk at]ieja pda nkhao kb pda lkoepera
`_d]nca kj pdkoa oepao kj ^ej`ejc ]j` ]`ajuhuh _u_h]oa ]_perepu*
`Ep s]o nalknpa` ej ]j a]nhean opq`u kb pda ?)paniej]h nacekj kb
`18
`21
`17
`pda dknikja pd]p pda ]j]hkc WHuo (Huo (Chq Ychq_]ckj at)
`de^epa` ajd]j_a` na_alpkn ^ej`ejc ]j` s]o ] oqlan]ckjeop $-5%*
`Pdeo ^ad]rekn s]o ]ppne^qpa` pk ]j ej_na]oa` )dahe_]h _kjpajp
`a
`]j` pda lkooe^ha bkni]pekj kb ]j ejpn]ikha_qh]n o]hp ^ne`ca
`^apsaaj _d]nca` oe`a _d]ejo ]p lkoepekjo -4 ]j` .- $.,( .-%*
`Kqn naoqhpo `aikjopn]pa pd]p chq_]ckj ^ej`ejc ]j` ]_perepu ]na
`jkp `e_p]pa` okhahu ^u aha_pnkop]pe_ ejpan]_pekjo ^qp ej_hq`a pda
`ejpan]_pekjo kb du`nkldk^e_ oe`a _d]ejo sepd pda na_alpkn*
`
`ATLANEIAJP=H LNK?A@QNAO
`9CMPGBC ;UKPFCOGO ?KB 9QNGDGA?PGLKVPdenpu pdnaa ]j]hkco kb chq_]ckj
`sepd nalh]_aiajpo ]p lkoepekjo -.( -3( ]j` -4 sana ]ooai^ha` ^u pda
`okhe`)ld]oa iapdk` $..( ./%( kj ]j =llhea` >ekouopaio 0/,= lalpe`a
`oujpdaoevan( qoejc lnk_a`qnao lnarekqohu `ao_ne^a` bkn pda oujpdaoeo kb
`chq_]ckj ]j]hkco $.0%* >neabhu( pda lalpe`a ]j]hkco sepd ?)paniej]h
`]ie`ao sana lnal]na` kj M)iapduh^ajvdu`nuh]ieja)naoej $Lalpe`ao Ej)
`panj]pekj]h( ,*22 iikh+c% qoejc 7 )>k_ WPCNP)^qpuhktu_]n^kjuhY lnkpa_)
`pekj _daieopnu* 7 )>k_)lnkpa_pa` ]iejk ]_e`o sana lqn_d]oa` bnki
`Lalpe`a Ejopepqpa* Oe`a _d]ej lnkpa_pekj s]o =nc$Pko%( =ol$K_Dt%( Chq)
`$K_Dt%( Deo$Pko%( HuoWV$?h%Y( Oan$>vh%( Pdn$>vh%( Pnl$Bkn%( ]j` Pun)
`WV$>n%Y $sdana Pko eo pkouh7 _Dt eo _u_hkdatuh7 V$?h% eo .)_dhknk^ajvuh)
`ktu_]n^kjuh7 >vh eo ^ajvuh7 ]j` Bkn eo bkniuh%* Op]j`]n` lnkpk_kh bkn
``kq^ha _kqlhejco sepd lnabknia` ouiiapne_ ]jdu`ne`ao ej `eiapduhbkn)
`i]ie`a sana qoa` nkqpejahu( at_alp bkn ]ncejeja( ]ol]n]ceja( ]j` chq)
`
`p]ieja sde_d sana _kqlha` ]o 7 )du`nktu^ajvkpne]vkha aopano $.1%* Pda
`7 )bkniuh cnkql kj pnulpkld]j s]o naikra` sepd 1,! lelane`eja ej
``eiapduhbkni]ie`a( lnekn pk DB pna]piajp* =bpan _ha]r]ca ^u ]jdu)
``nkqo DB( pda _nq`a lalpe`ao sana lqnebea` ^u lnal]n]pera hks lnaooqna
`naranoa)ld]oa hemqe` _dnki]pkcn]ldu kj k_p]`a_uh)oehe_] $Ru`]_ ?-4(
`Oal]n]pekjo Cnkql%* Pda lalpe`ao sana ahqpa` ^u ]llhuejc ] heja]n
`cn]`eajp kb .1® 0,! ]_apkjepneha ej ,*,1! pnebhqknk]_ape_ ]_e`* Lqnepu kb
`pda hukldeheva` lnk`q_p s]o ar]hq]pa` ^u ]j]hupe_]h decd lnaooqna hem)
`qe` _dnki]pkcn]ldu $Ru`]_ .-4PL10% ej ]p ha]op psk `ebbanajp okhrajp
`ouopaio ]j` i]oo ola_pn]h ]j]huoeo ^u pda aha_pnkoln]u iapdk` e`ajpe)
`bea` pda atla_pa` $I " D% la]go sepdej %,*/ @]* =iejk ]_e` ]j]huoeo
`ueah`a` ]iejk ]_e` _kilkoepekjo _kjoeopajp sepd pdaknu*
`:CACMPLN -GKBGKE ,OO?UVHeran lh]oi] iai^n]jao sana lnal]na`
`bnki n]p heran $Oln]cqa)@]shau( -,, ®-1, c( ?d]nhao Neran% bkhhksejc
`pda iapdk` kb Jarehha sepd ik`ebe_]pekjo `ao_ne^a` ^u Lkdh $.2%* Iai)
`^n]ja ]hemqkpo sana opkna` ej hemqe` jepnkcaj ]j` qoa` sepdej 0 ® 2
`ikjpdo* Pda na_alpkn ^ej`ejc ]oo]u s]o `kja ]__kn`ejc pk Snecdp ]j`
`c kb
`Nk`^ahh $.3%( ej sde_d _kilapepekj bkn chq_]ckj na_alpkno ej -,
`E)h]^aha` chq_]ckj $JAJ Heba O_e)
`heran iai^n]ja lnkpaej( ^apsaaj
`125
`aj_a Lnk`q_po% $-*2 jI% ]j` pda oujpdape_ ]j]hkco ej _kj_ajpn]pekjo
`pk -, I( s]o ia]oqna`* =oo]u oqolajoekjo sana
`-5
`-11
`n]jcejc bnki -,
`behpana` kj @qn]lkna iai^n]ja behpano $,*01 i% qoejc ] r]_qqi beh)
`1
`pn]pekj i]jebkh` $Iehhelkna%* >ej`ejc ]bbejepu $lan_ajp% eo _]h_qh]pa` ]o
`pda n]pek kb pda _kj_ajpn]pekj kb chq_]ckj pd]p ejde^epo 1,! kb pda
`^ej`ejc kb pn]_an $E? % pk pd]p kb lalpe`a ]j]hkc $ -,,* @qlhe_]pa
``apaniej]pekjo sana i]`a bkn a]_d _kj_ajpn]pekj lkejp( ]j` a]_d ]oo]u
`s]o nqj ]p ha]op pse_a* Jkjola_ebe_ ^ej`ejc( `apanieja` ej pda lnaoaj_a
`kb -, I qjh]^aha` chq_]ckj( s]o pule_]hhu -,! kb pkp]h ^ej`ejc*
`,BCKUIUI .UAI?OC ,OO?UV=`ajuhuh _u_h]oa ]_perepu s]o ia]oqna`
`]__kn`ejc pk pda lnk_a`qna `ao_ne^a` ^u O]hkikj CP ?I% $.4%* _=IL
`naha]oa` s]o `apanieja` sepd ] _kiian_e]hhu ]r]eh]^ha ]oo]u gep( bnki
`=ianod]i Ld]ni]_e] >ekpa_d( ej sde_d qjh]^aha` _=IL lnk`q_a`
`_kilapao sepd W4) DY_=IL bkn ] _=IL)^ej`ejc lnkpaej* @]p] bkn opei)
`qh]pekj kb ]`ajuhuh _u_h]oa ]na atlnaooa` ]o le_kikhao kb _=IL lnk)
``q_a` lan ic kb iai^n]ja lnkpaej lan iej ]j` lhkppa` ]c]ejop pda
`hkc]nepdi kb lalpe`a ]j]hkc _kj_ajpn]pekj* I]teiqi ]_perepu $lan_ajp%
`kb ]j ]j]hkc eo pda lan_ajp]ca kb i]teiqi opeiqh]pekj kb _=IL lnk)
``q_pekj ]^kra ^]o]h ^u chq_]ckj* Nah]pera lkpaj_u $lan_ajp% eo pda n]pek
`kb pda _kj_ajpn]pekj kb j]pqn]h chq_]ckj pd]p ahe_epo 1,! i]teiqi
`lnk`q_pekj kb _=IL $A? % pk pd]p _kj_ajpn]pekj kb lalpe`a ]j]hkc $
`-,,* Ejde^epekj kb _=IL lnk`q_pekj s]o `apanieja` ej ] oeieh]n ]oo]u
`ej sde_d ] _kjop]jp ]ikqjp kb chq_]ckj eo ]hhksa` pk _kilapa sepd
`eo `a)
`ej_na]oejc _kj_ajpn]pekjo kb ]j]hkc* Pda ejde^epekj ej`at $E+=%
`50
`beja` ]o pda n]pek kb pda _kj_ajpn]pekjo kb ejde^epkn pk ]ckjeop sdaj pda
`naolkjoa eo na`q_a` pk 1,! kb pda naolkjoa pk ]ckjeop ej pda ]^oaj_a kb
`ejde^epkn* =j]hkco sana paopa` bkn ejde^epknu lnklanpeao eb pdau d]`
`nah]pera lkpaj_eao kb !-! ]j` ] ^ej`ejc ]bbejepu kb "-!* Pda M= r]hqa(
`2
`_]h_qh]pa` ^u pda iapdk` kb =nqjh]god]j] ]j` O_deh` $.5%( eo pda
`jac]pera hkc]nepdi kb pda _kj_ajpn]pekj kb ejde^epkn pd]p na`q_ao pda
`naolkjoa pk - qjep kb ]ckjeop pk pda naolkjoa lnk`q_a` ^u ,*1 qjep kb
`]ckjeop* @qlhe_]pa `apaniej]pekjo sana i]`a bkn a]_d _kj_ajpn]pekj
`lkejp( ]j` a]_d atlaneiajp s]o _]nnea` kqp ]p ha]op pse_a*
`
`50
`
`50
`
`-5
`
`
`
`-,/-,
`
`2IQA?ELK ;PNQAPQNC ?KB 1QKAPGLK
`
`P=>HA E
`2IQA?ELK ?K?ILEO SGPF KCQPN?I NCOGBQC NCMI?ACJCKPO ?P MLOGPGLKO '(# ')# ?KB '*
`
`=`ajuhuh _u_h]oa ]_perepu
`
`=j]hkc kb chq_]ckj ]ie`a?
`
`Chq_]ckj ]ie`a
`12
`-* =h]
`12
`I
`.* `ao)Deo (=h]
`12
`/* Chu
`12
`1
`0* `ao)Deo (Chu
`12
`e
`1* 7 )]_apuh)Huo
`17
`2* =h]
`17
`1
`3* `ao)Deo (=h]
`17
`4* Haq
`1
`17
`5* `ao)Deo (Haq
`18
`-,* =h]
`18
`--* `ao)Deo (=h]
`18
`-.* Haq
`18
`1
`-/* `ao)Deo (Haq
`17
`18
`-0* =h] (=h]
`17
`1
`18
`-1* `ao)Deo (=h] (=h]
`17
`18
`-2* Haq (Haq
`18
`17
`1
`-3* `ao)Deo (Haq (Haq
`12
`17
`18
`-4* =h] (=h] (=h]
`
`>ej`ejc
`]bbejepu@
`
`!
`-,,
`-3*/ % ,*.
`,*5-
`--*0
`,*14
`03 % -
`/4
`.*/
`/, % -*4
`5*/
`-/
`/*-
`12 % -*1
`/*2
`4
`,*/.
`3 % ,*-
`-
`,*,4
`
`I]teiqi
`]_perepuA
`
`!
`-,,
`15*3
`-.*1
`41*-
`-5*0
`5,*1
`.5
`.4
`44 % .
`./
`50*0
`-0
`51 % /
`..*1
`53
`-,
`41*0 % ,*4
`-3
`2.*4
`
`Nah]pera
`lkpaj_uB
`
`!
`
`-1
`-1*4
`,*-1
`-/*4
`,*-/
`/-*2
`,*,-/
`,*.4
`/3*- % -*3
`.*-/
`3,*4
`,*-0
`01*3 % -*2
`-*1
`.3*1
`,*-5
`1.*1 % -*.
`-*-1
`-*/
`
`C
`$E+=%1,
`
`D
`M=.
`
`0/*3
`
`/0*3
`
`0/*3
`
`41*-
`
`0/*3
`
`3*,
`
`3*1
`
`3*/
`
`3*,
`
`3*-
`
`d
`
`=j]hkco kb chq_]ckj ]ie`a sana ]oo]ua` qoejc j]pera chq_]ckj ]o pda op]j`]n`( ej ^kpd iai^n]ja ^ej`ejc ]j` ]`ajuhuh _u_h]oa ]_perepu*
`1
`W`ao)Deo YChq_]ckj ]ie`a d]` ] ^ej`ejc ]bbejepu kb 2/! ]j` ] nah]pera lkpaj_u kb ,*-2! ej pda ]`ajuhuh _u_h]oa ]oo]u*
`b
`>ej`ejc ]bbejepu $!% eo pda n]pek kb ]ckjeop _kj_ajpn]pekj pk ]j]hkc _kj_ajpn]pekj ]p 1,! na_alpkn k__ql]j_u $E? % $ -,,*
`50
`I]teiqi ]_perepu $!% eo pda lan_ajp]ca kb i]teiqi chq_]ckj opeiqh]pekj kb _=IL lnk`q_pekj ]^kra ^]o]h*
`Nah]pera lkpaj_u $!% eo pda n]pek kb chq_]ckj _kj_ajpn]pekj pk ]j]hkc _kj_ajpn]pekj ]p 1,! naolkjoa $A? % $ -,,*
`50
`eo pda n]pek kb lalpe`a ejde^epkn _kj_ajpn]pekj pk chq_]ckj _kj_ajpn]pekj sdaj pda naolkjoa eo na`q_a` pk 1,! kb pda
`Pda ejde^epekj ej`at $E+=%
`50
`naolkjoa kb ]ckjeop ej pda ]^oaj_a kb ejde^epkn*
`Pda M= r]hqa eo pda jac]pera hkc]nepdi kb pda _kj_ajpn]pekj kb ejde^epkn pd]p na`q_ao pda naolkjoa pk - qjep kb ]ckjeop pk pda naolkjoa k^p]eja`
`2
`bnki ,*1 qjep kb ]ckjeop*
`
`NAOQHPO
`
`Pdenpu pdnaa chq_]ckj ]j]hkco d]ra ^aaj oujpdaoeva` pk ]o)
`oaoo pda nkhao kb pda lkoeperahu _d]nca` ^]oe_ naoe`qao ]p lkoe)
`pekjo -.( -3( ]j` -4 kb chq_]ckj( ej na_alpkn ^ej`ejc ]bbejepu ]o
`sahh ]o ej ]`ajuhuh _u_h]oa ]_per]pekj* Kqn ejepe]h ]llnk]_d s]o
`pk at]ieja pda abba_p kb jaqpn]hevejc pda lkoepera _d]nca ^u
`oq^opepqpejc qj_d]nca` ]iejk ]_e`o ]p lkoepekjo -.( -3( ]j` -4
`12
`$P]^ha E%* Nalh]_ejc Huo sepd jaqpn]h naoe`qao ej pda ]j]hkco
`12
`12
`=h]
`]j` Chu
`chq_]ckj ]ie`ao $]j]hkco - ]j` /% naoqhpa` ej
`]j 4, ®5,! na`q_pekj ej ^ej`ejc ]bbejepu nah]pera pk chq_]ckj bkn
`pda chq_]ckj na_alpkn ej n]p heran iai^n]jao* Dksaran( ^kpd
`]j]hkco sana opehh _]l]^ha kb ] bqhh ]ckjeop naolkjoa( sepd na)
``q_a` lkpaj_u* Oeieh]nhu( ]_apuh]pekj kb pda )]iejk cnkql kb
`E
`12
`a
`12
`lnkre`a` W7 )]_apuh)Huo Ychq_]ckj ]ie`a $]j]hkc 1%(
`Huo
`sde_d ^kqj` sepd 03! ]bbejepu ]j` ahe_epa` 5,! i]teiqi
`]`ajuhuh _u_h]oa opeiqh]pekj* Pdaoa naoqhpo sana _kjoeopajp
`sepd ]j a]nhean k^oanr]pekj pd]p 7 )]_uh]pa` `aner]perao kb
`chq_]ckj sana bqhh ]ckjeopo $/,% ]j` bqnpdan eilhe_]pa` ] lnab)
`anaj_a bkn ] du`nkldk^e_ bqj_pekj]h cnkql ]p lkoepekj -.* =j
`17
`at_d]jca kb =nc
`bkn ]h]jeja kn haq_eja ej ]j]hkco 2 ]j` 4
`17
`$P]^ha E% abba_pa` ] hkoo kb 2, ®3,! ^ej`ejc ]bbejepu* =h] s]o ]
`17
`sa]g ]ckjeop( sdana]o Haq opeiqh]pa` ]`ajuhuh _u_h]oa sepd
`18
`]j 44! i]teiqi ]_perepu* Nalh]_ejc =nc sepd ]h]jeja $]j)
`]hkc -,% ha` pk ]j 43! hkoo ej ^ej`ejc( sdana]o ] ikna du`nk)
`ldk^e_ haq_eja oq^opepqpekj $]j]hkc -.% oqbbana` ] oi]hhan hkoo
`kb 00! ]bbejepu* >kpd ]j]hkco sana _]l]^ha kb ] bqhh ]ckjeop
`naolkjoa* Oq^opepqpekj kb ^kpd oamqajpe]h ]ncejejao sepd ] jaqpn]h
`17
`18
`17
`18
`]iejk ]_e` ej =h] (=h] $]j]hkc -0% ]j` Haq (Haq $]j]hkc -2%
`17
`18
`naoqhpa` ej ] 5,! hkoo kb ^ej`ejc( sde_d ej pda _]oa kb Haq (Haq
`]lla]na` pk ^a ]``epera* Pda _kj_qnnajp hkoo kb ^kpd lkoepera
`_d]ncao `e` jkp ejbhqaj_a pda ]^ehepu pk ]_per]pa ]`ajuhuh _u_h]oa
`oej_a pda `kq^hu oq^opepqpa` ]j]hkco sana bqhh ]ckjeopo ^qp sepd
`hksana` lkpaj_u* Ej _kjpn]op( pda at_d]jca kb ]hh pdnaa ^]oe_ naoe)
`12
`17
`18
``qao sepd ]h]jejao ej W=h] (=h] (=h] Ychq_]ckj ]ie`a ej`q_a`
`]hikop _kilhapa hkoo kb ^ej`ejc ]j` naoqhpa` ej ] ranu sa]g l]npe]h
`1
`]ckjeop* @ahapekj kb Deo bnki okia kb pda ]j]hkco pd]p nap]eja`
`
`ckk` ^ej`ejc ]bbejepeao $]j]hkco 2( 4( -,( -.( ]j` -2%( lnk`q_a` pda
`1
`_knnaolkj`ejc `ao)Deo `aner]perao $]j]hkco 3( 5( --( -/( ]j` -3%
`pd]p atde^epa` hksana` lkpaj_eao ]j` ia]oqn]^ha ]jp]ckjeop lnkl)
`anpeao( sde_d eo _kjoeopajp sepd pda aop]^heoda` nkha kb deope`eja ej
`chq_]ckj $5®-.%* >a_]qoa pdaoa `ao)Deo ]j]hkco nap]eja` pda _])
`l]_epu pk ej`q_a hks haraho kb _=IL( pdau sana kjhu l]npe]h chq_]ckj
`]jp]ckjeopo $/-%*
`=oe`a bnki jaqpn]h ]iejk ]_e`o( lkoepera naoe`qao ]p lkoe)
`pekjo -.( -3( ]j` -4 sana a]_d nalh]_a` sepd ]j ]ol]npe_ kn
`chqp]ie_ ]_e` pk at]ieja pda abba_p kb ] narano]h kb _d]nca*
`12
`12
`=ol
`]j` Chq
`$]j]hkco -5 ]j` .,( P]^ha EE% `eolh]ua` lkkn
`^ej`ejc ]bbejepeao kb ,*2 ]j` -!( naola_perahu* Hegaseoa( oq^ope)
`17
`pqpekj ^u ]ol]npe_ ]_e` ]p lkoepekjo -3 kn -4 ]o ej W=ol Y) ]j`
`18
`W=ol Ychq_]ckj ]ie`ao $]j]hkco .. ]j` .2% ha` pk 55! hkoo kb
`^ej`ejc* Ejpanaopejchu( chqp]ie_ ]_e` s]o ^appan pkhan]pa` ]p
`17
`18
`pdaoa lkoepekjo( sepd Chq ]j` Chq chq_]ckj ]ie`ao $]j]hkco
`.0 ]j` .4% atde^epejc ] napajpekj kb .- ]j` 2! ^ej`ejc ]bbejepu(
`naola_perahu( ]j` bqhh opeiqh]pekj kb ]`ajuhuh _u_h]oa* @aolepa
`na`q_a` ^ej`ejc ]bbejepeao ] narano]h kb _d]nca ]p ]hh lkoepekjo
`lnk`q_a` chq_]ckj ]j]hkco pd]p ahe_epa` oq^op]jpe]h ]ckjeop
`17
`18
`naolkjoao ]hpdkqcd sepd na`q_a` lkpaj_eao* Qjhega =h] (=h] (
`dksaran( ] `kq^ha nalh]_aiajp sepd ]_e`e_ naoe`qao ej
`17
`18
`17
`18
`W=ol (=ol Y) ]j` ej WChq (Chq Ychq_]ckj ]ie`ao $]j]hkco /,
`]j` /.% naj`ana` pda lalpe`ao ej_]l]^ha kb na_alpkn na_kcje)
`pekj* Oej_a ep eo ]_gjksha`ca` pd]p ]j ejp]_p J)paniej]h deope)
``eja lnkre`ao `apaniej]jpo bkn ^kpd pda ^ej`ejc ]j` ]_per]pekj
`bqj_pekj kb chq_]ckj( pda `ao)deope`eja `aner]pera kb aranu lk)
`oepekj #-.( #-3( ]j` #-4 nalh]_aiajp ]j]hkc lna`e_p]^hu hkop
`]``epekj]h na_alpkn ^ej`ejc ]bbejepu ]j` lkpaj_u kb ]`ajuhuh
`_u_h]oa ]_per]pekj*
`
`@EO?QOOEKJ
`
`Pdana eo najasa` ejpanaop ej pda lalpe`a chq_]ckj ^a_]qoa kb
`epo nkha ej `e]^apao iahhepqo* @aolepa _kjoe`an]^ha lkoepera are)
``aj_a( pda l]npe_el]pekj kb chq_]ckj eo opehh okiasd]p _kjpnk)
`ranoe]h ]j` bqnpdan are`aj_a bkn epo nkha eo jaa`a`* Ep d]o ^aaj
`
`
`
`2IQA?ELK ;PNQAPQNC ?KB 1QKAPGLK
`
`-,/--
`
`P=>HA EE
`2IQA?ELK ?K?ILEO SGPF ?AGBGA NCOGBQC NCMI?ACJCKPO ?P MLOGPGLKO '(# ')# ?KB '*
`
`=`ajuhuh _u_h]oa ]_perepu
`
`=j]hkc kb chq_]ckj ]ie`a?
`
`Chq_]ckj ]ie`a
`12
`-5* =ol
`12
`.,* Chq
`12
`.-* `ao)Deo (Chq
`17
`..* =ol
`17
`./* `ao)Deo (=ol
`17
`.0* Chq
`17
`.1* `ao)Deo (Chq
`18
`.2* =ol
`18
`.3* `ao)Deo (=ol
`18
`.4* Chq
`18
`1
`.5* `ao)Deo (Chq
`17
`18
`/,* =ol (=ol
`18
`17
`1
`/-* `ao)Deo (=ol (=ol
`17
`18
`/.* Chq (Chq
`17
`1
`18
`//* `ao)Deo (Chq (Chq
`
`>ej`ejc
`]bbejepu@
`
`!
`-,,
`,*2
`-
`,*--
`-*0
`,*-
`.-*/ % ,*1
`-*3
`,*..
`!,*,/4
`2*. % ,*.
`,*00
`!,*,/.
`!,*,/.
`,*,/2
`!,*,1,
`
`I]teiqi
`]_perepuA
`
`!
`-,,
`34*0
`4,*0
`.4
`4.*0
`--*1
`50*4 % ,*.
`.-*1
`25*.
`
`-,, % .
`-4
`
`Nah]pera
`lkpaj_uB
`
`!
`-1
`-,
`1,*-
`,*..
`0*0
`,*,4
`0,*3 % /
`-*,
`,*.0
`
`/*/ % ,*/
`,*.0
`
`-,,
`
`-*.
`
`C
`$E+=%1,
`
`D
`M=.
`
`13*1
`
`2*0
`
`=j]hkco kb chq_]ckj ]ie`a sana ]oo]ua` qoejc j]pera chq_]ckj ]o pda op]j`]n`( ej ^kpd iai^n]ja ^ej`ejc ]j` ]`ajuhuh _u_h]oa ]_perepu*
`1
`W`ao)Deo YChq_]ckj ]ie`a d]` ] ^ej`ejc ]bbejepu kb 2/! ]j` ] nah]pera lkpaj_u kb ,*-2! ej pda ]`ajuhuh _u_h]oa ]oo]u*
`b
`>ej`ejc ]bbejepu $!% eo pda n]pek kb ]ckjeop _kj_ajpn]pekj pk ]j]hkc _kj_ajpn]pekj ]p 1,! na_alpkn k__ql]j_u $E? % $ -,,*
`50
`I]teiqi ]_perepu $!% eo pda lan_ajp]ca kb i]teiqi chq_]ckj opeiqh]pekj kb _=IL lnk`q_pekj ]^kra ^]o]h*
`a
`Nah]pera lkpaj_u $!% eo pda n]pek kb chq_]ckj _kj_ajpn]pekj pk ]j]hkc _kj_ajpn]pekj ]p 1,! naolkjoa $A? % $ -,,*
`60
`eo pda n]pek kb lalpe`a ejde^epkn _kj_ajpn]pekj pk chq_]ckj _kj_ajpn]pekj sdaj pda naolkjoa eo na`q_a` pk 1,! kb pda
`Pda ejde^epekj ej`at $E+=%
`50
`naolkjoa kb ]ckjeop ej pda ]^oaj_a kb ejde^epkn*
`Pda M= r]hqa eo pda jac]pera hkc]nepdi kb pda _kj_ajpn]pekj kb ejde^epkn pd]p na`q_ao pda naolkjoa pk - qjep kb ]ckjeop pk pda naolkjoa k^p]eja`
`2
`bnki ,*1 qjep kb ]ckjeop*
`
`k^oanra` pd]p kranlnk`q_pekj kb chq_koa ^u ahar]pa` _en_qh]pejc
`haraho kb chq_]ckj i]u ^a ] _kjpne^qpejc b]_pkn pk dulanchu_a)
`ie] ]j` gapk]_e`koeo pd]p eo _d]n]_paneope_ kb pda `eoa]oa $/.(
`//%* Ep s]o na]okj]^ha pk ]ooqia pd]p ]jp]ckjeopo kb pda dkn)
`ikja pd]p ]na ]^ha pk ejde^ep pda ]_pekjo kb pdeo aj`kcajkqo
`chq_]ckj ^u _kilapejc bkn pda o]ia ^ej`ejc _]repu ej pda
`chq_]ckj na_alpkn _kqh` d]ra _heje_]h lkpajpe]h ej pda i]j]ca)
`iajp kb `e]^ape_ _kilhe_]pekjo $5( /.( //%* Ej`aa`( oaran]h lal)
`pe`a ]j]hkco d]ra ^aaj `arahkla` pd]p d]ra ^aaj odksj pk
`abba_perahu ejde^ep pda abba_po kb chq_]ckj ^kpd GK RGPNL ]j` GK
`RGRL $.0( /-( /0 ®/4%* ?kjpejqa` abbknpo ej pda opq`u kb chq_]ckj
`]na olqnna` ^u pda e`a] pd]p pda ]^ehepu pk oejcha kqp ola_ebe_
`_kjp]_p lkejpo ^apsaaj pda lalpe`a hec]j` ]j` epo na_alpkn
`lnkpaej skqh` oanra ]o ] ^]oeo bkn pda n]pekj]h `aoecj kb ]j]hkco
`pd]p ^ej` uap `k jkp ]_per]pa ]`ajuhuh _u_h]oa*
`Pdeo opq`u kb pda aha_pnkop]pe_ ejpan]_pekj kb pda ^]oe_ naoe)
`12
`17
`18
``qao Huo ( =nc ( ]j` =nc
`kb chq_]ckj sepd ]_e`e_ naoe`qao kb
`pda chq_]ckj na_alpkn eo ^]oa` kj pda oqllkoepekj pd]p ]ju kja
`kn ]hh kb pdaoa cnkqlo i]u lnkre`a ] _kqjpanekj pk ] ola_ebe_
`]ol]npe_ ]_e` naoe`qa kj pda atpn]_ahhqh]n `ki]ej kb pda na_al)
`pkn pd]p d]o ^aaj odksj ej na_ajp iqp]cajaoeo opq`eao pk ^a
`_nepe_]h bkn hec]j` na_kcjepekj $-1( -4%* Pda eilknp]j_a kb deope)
``eja ]p lkoepekj - pk ^kpd na_alpkn ^ej`ejc ]j` ]_per]pekj d]o
`^aaj benihu aop]^heoda` $5 ®-.%* Naikr]h kb pda deope`eja cnkql
`]bbkn`a` ]j ]j]hkc pd]p nap]eja` ]bbejepu bkn pda na_alpkn ^qp(
`ikna eilknp]jphu( ]lla]na` pk l]npe]hhu ejde^ep chq_]ckj)opei)
`qh]pa` ]`ajuhuh _u_h]oa $5%* =hpdkqcd pda J)paniej]h deope`eja
`eo opne_phu _kjoanra` sepdej pda chq_]ckj b]iehu kb lalpe`a
`12
`17
`18
`dknikjao( Huo ( =nc ( ]j` =nc
`]na nah]perahu qjemqa ]p
`pdaoa lkoepekjo ej chq_]ckj ]j` iecdp ]hok oanra ]o `apanie)
`j]jpo kb na_alpkn ola_ebe_epu*
`Pda naoqhpo kb kqn opq`u nara]h pd]p sdeha jaqpn]h naoe`qa
`o_]jjejc kb lkoepekjo -.( -3( kn -4 kb chq_]ckj opnkjchu ]ppaj)
`q]pa` na_alpkn ^ej`ejc( ikop kb pda naoqhpejc ]j]hkco sana
`sa]g ^qp bqhh ]ckjeopo( oqccaopejc pd]p ] lkoepera _d]nca ]p
`pdaoa l]npe_qh]n lkoepekjo s]o jkp ]^okhqpahu _nepe_]h bkn ]_per)
`epu* Pd]p jk lkoeperahu _d]nca` ]iejk ]_e`o kb chq_]ckj( sepd
`pda at_alpekj kb deope`eja -( ]na _nepe_]h bkn pda ]_per]pekj bqj_)
`pekj eo ej`e_]pa` ^u pda k^oanr]pekj pd]p jkja kb pda nalh]_a)
`
`glucagon H SOO T F T SD V SK Y LD SR R A 0 D F VC) LM NT -
`glpl HIAEG T F T SDV SSY L EGG A A KEF I AW LV KG R
`secretin HSDG T F T SE L SR LOD SAR L OR L LQG LV
`vip HSDAV F TDNY TR LRKQMA V KKY LNS I L N--
`
`Consensus HSDG T F T SD SR
`
`D
`
`A
`
`F LQ LV
`
`BEC* .* :BMQBJ@B >HFDJIBJP KC LBLPFABO KC PEB DHQ@>DKJ C>IFHU
`PE>P E>RB @HKOB EKIKHKDU$ Naoe`qao pd]p ]na _kjoanra` ej aepdan
`_d]nca kn du`nkldk^e_ _d]n]_pan ]na @LTCB*
`
`iajp ]j]hkco ej P]^ha E ^ad]ra` ]o ]jp]ckjeopo* Dksaran(
`1
`okia kb pda _knnaolkj`ejc `ao)Deo `aner]perao kb lkoepekjo -3
`]j` -4 nalh]_aiajp ]j]hkco `eolh]ua` l]npe]h ]jp]ckjeop lnkl)
`anpeao( sde_d s]o pdanabkna ]ook_e]pa` sepd pda `ahapekj kb
`lkoepekj - deope`eja $/-%* Pdaoa sana ej pda $E+=%
`n]jca kb
`50
`/0 ® 41( sdana]o pda ikop lkpajp chq_]ckj ]jp]ckjeop nalknpa`
`pk `]pa s]o ,*41 $/2%*
`= jac]perahu _d]nca` ]_e`e_ ]iejk ]_e` s]o( dksaran( haoo
`pkhan]pa` ]p pdaoa lkoepekjo ]j` eil]ena` na_alpkn ^ej`ejc ^u ]
`dqj`na`)bkh` kn ikna* Opnkjchu na`q_a` ^ej`ejc ]bbejepeao sana
`_kqlha` sepd ]`ajuhuh _u_h]oa naolkjoao sepd iq_d sa]gaja`
`lkpaj_eao* Pdqo( ] lkoepera _d]nca ]p pdaoa lkoepekjo eo ja_ao)
`o]nu bkn klpei]h dknikj]h bqj_pekj*
`Kqn lnarekqo bej`ejco aop]^heoda` pda nkhao kb pda ]ol]npe_
`9
`]_e` naoe`qao ]p lkoepekjo 5( -1( ]j` .- kb chq_]ckj* =ol eo
`_nepe_]h bkn pn]jo`q_pekj ^qp jkp bkn ^ej`ejc $3%( sdana]o pda
`15
`jac]pera _d]nca ]p =ol eo ]^okhqpahu aooajpe]h bkn ^ej`ejc $4%*
`Ej _kjpn]op( pda lkoeperahu _d]nca` naoe`qao ej pda _ajpn]h na)
`cekj kb pda dknikja d]ra ] ola_ebe_ nkha ej ]_dearejc klpei]h( kn
`araj oecjebe_]jp( ^ej`ejc ]j` i]tei]h ^ekhkce_]h lkpaj_u* =j
`]hpan]pekj ej pda _d]nca `eopne^qpekj ]hkjc pda ikha_qha _ha]nhu
`naoqhpo ej `a_na]oa` ^ej`ejc kb pda `aner]perao* Qjhega lkoe)
`pekjo 5 ]j` -1 sdana pda lna_eoa hk_]pekj kb ]j ]ol]npe_ ]_e`
`naoe`qa eo _nepe_]h pk dknikja)na_alpkn ejpan]_pekj( ep ]lla]no
`pd]p chq_]ckj ^ej`ejc ]bbejepu eo jkp nacqh]pa` ^u pda pklk)
`cn]lde_ hk_]pekj kb ] ola_ebe_ lkoepera _d]nca ^qp ^u ] jap lko)
`epera _d]nca* =j kran]hh lkoeperahu _d]nca` ikha_qha `abejepahu
`ajd]j_ao pda ]bbejepu bkn epo iai^n]ja)^kqj` na_alpkn lnkpaej*
`= oejcha nalh]_aiajp ej chq_]ckj ]ie`a sepd ]j qj_d]nca`
`naoe`qa `e` jkp ]`amq]pahu ]hpan pda kran]hh _d]nca pk na`q_a
`
`
`
`-,/-.
`
`2IQA?ELK ;PNQAPQNC ?KB 1QKAPGLK
`
`^ej`ejc ]j` ]_perepu( ^qp kja oq^opepqpekj sepd ] jac]perahu
`_d]nca` naoe`qa naoqhpa` ej ] jaqpn]h ikha_qha*
`Oa_napej( CHL)-( ]j` r]ok]_pera ejpaopej]h lalpe`a( chq_])
`ckj#o _hkoaop nah]perao sepdej pda b]iehu kb lalpe`a dknikjao(
`od]na 1,! oamqaj_a dkikhkcu ikophu ]p pda J)paniej]h d]hb kb
`1
`pda ikha_qha $Bec* .%* Sepd pda at_alpekj kb Deo ( pda lkoepekjo
`kb ^]oe_ naoe`qao o_]ppana` lnei]nehu ]hkjc pda ?)paniej]h l]np
`kb pdaoa oamqaj_ao ]na jkp sahh _kjoanra`* Ej ]j a]nhean nalknp(
`] chq_]ckj)CHL)- _deiane_ lalpe`a( ej sde_d pda benop -0 naoe)
``qao kb chq_]ckj sana _ki^eja` sepd pda h]op -2 naoe`qao kb
`CHL)-( ^kqj` pk ^kpd chq_]ckj ]j` CHL)- na_alpkno $/5%* Pda
`jkni]h lalpe`ao kjhu ^ej` sa]ghu pk a]_d kpdan#o na_alpkn*
`Ejpanaopejchu( sd]p ]lla]no pk ^a lnaoanra` eo ]j kran]hh lkoe)
`pera _d]nca( oqccaopejc pd]p ] lkoeperahu _d]nca` hec]j` i]u ^a
`kja namqeoepa ba]pqna _kiikj pk iai^ano kb pdeo C lnkpaej)
`_kqlha` na_alpkn oq^)cnkql ]j` pdanabkna jkp ] opne_p `apanie)
`j]jp kb ola_ebe_epu*
`Pda opq`u ]hok nara]ho ] du`nkldk^e_epu _kilkjajp kb pda
`^ej`ejc ejpan]_pekj* Pda ^]oe_ ]iejk ]_e`o ]ncejeja ]j` huoeja
`_]j _kjpne^qpa jkp kjhu ] _d]nca` cnkql ^qp ]hok ]j ]held]pe_
`_kilkjajp pk pda lkh]n ]j` jkj)lkh]n ejpanb]_a kb pda hec]j`
`^ej`ejc lk_gap* Pda lnklkoa` hec]j` ^ej`ejc oepa odkqh` hea
`sepdej ] du`nkldk^e_ _kna kb pda na_alpkn sdana jkjola_ebe_
`du`nkldk^e_ ejpan]_pekjo ^apsaaj pda dknikja ]j` epo na_alpkn
`ai^a``a` ej pda iai^n]ja ^eh]uan ]qciajp ^ej`ejc ]bbejepu*
`Pdeo atlh]ejo sdu oq^opepqpekj sepd ] jaqpn]h uap du`nkldk^e_
`ikha_qha hega ]h]jeja kn haq_eja s]o sahh pkhan]pa` `aolepa pda
`hkoo kb ] lkoepera _d]nca ]j` _kqh` oqop]ej /, ® 2,! kb pda
`]bbejepu bkn pda na_alpkn* = narano]h kb _d]nca kj pda kpdan d]j`
`]`ranoahu ]hpana` pda lkh]n _d]n]_pan kb pda lalpe`a ]j` ha` pk
`] cna]pan hkoo kb na_alpkn na_kcjepekj $P]^ha EE%* Jaranpdahaoo(
`]j ej_na]oa` du`nkldk^e_ _kjpne^qpekj bnki ] chqp]ie_ ]_e`
`oe`a _d]ej lnk^]^hu _kilajo]pa` bkn pda narano]h kb _d]nca ]j`
`]__kqjpa` bkn pda napajpekj kb oq^op]jpe]h ^ej`ejc ]bbejepu ]j`
`17
`18
`lkpaj_u kb pda Chq
`]j` Chq
`nalh]_aiajp ]j]hkco $]j]hkco
`1
`17
`.0 ]j` .4( P]^ha EE%* Ej ]``epekj( `ao)Deo (Chq
`$]j]hkc .1(
`P]^ha EE%( sde_d nap]eja` .! ^ej`ejc ]j` ] sa]gaja` lkpaj_u
``qa pk `ahapekj kb deope`eja( s]o opehh ] l]npe]h ]jp]ckjeop* Pda
`17
`18
`21
`]j]hkc WHuo (Huo (Chq Ychq_]ckj d]o ^aaj nalknpa` pk ^a ]
`oqlan]ckjeop sde_d ^kqj` 1)bkh` ^appan pd]j pda j]pqn]h dkn)
`ikja ]j` d]` ] decdan lkpaj_u $-5( .,%* = na_ajp t)n]u _nuop]h
`17
`18
`21
`opnq_pqna bkn WHuo (Huo (Chq Ychq_]ckj oqccaopa` pd]p pda
`18
`bkni]pekj kb ] o]hp ^ne`ca ^apsaaj pda )]iejk cnkql kb Huo
`E
`21
`]j` pda _]n^ktuh kb Chq i]u op]^eheva pda pqnj kb ] lqp]pera
`)dahet ]p naoe`qao -4 ®.- ]j` _kjpne^qpao pk epo oqlan]ckjeop
`]_perepu $.-%* Dksaran( ^ej`ejc ]bbejepu nai]ejo nah]perahu decd
`araj sdaj du`nkldk^e_ naoe`qao ]na oq^opepqpa` bkn aepdan
`17
`18
`=nc
`kn =nc * Lnaoqi]^hu( ajd]j_a` ]_perepu i]u ]hok ^a
`]ppne^qpa` pk pda ej_na]oa` du`nkldk^e_epu kb pda hkjcan ]he)
`ld]pe_ oe`a _d]ejo kb huoeja ]j` chqp]ie_ ]_e` nah]pera pk pdkoa
`kb pda jkni]h ]ncejeja ]j` ]ol]npe_ ]_e` naoe`qao*
`17
`12
`Pdqo( pda lkoeperahu _d]nca` ]iejk ]_e`o Huo ( =nc ( ]j`
`18
`=nc
`kb chq_]ckj d]ra h]nca abba_po ^qp ]na jkp ]^okhqpahu
`_nepe_]h bkn pda ^ej`ejc ]j` ]_per]pekj bqj_pekj kb pda dknikja*
`Dksaran( pda bqj_pekj]h cnkqlo kb pdaoa ^]oe_ naoe`qao ^khopan
`^kpd pda lkh]n ]j` jkj)lkh]n ]ola_po kb pda lalpe`a ]j` lnkpaej
`ejpan]_pekjo pd]p k__qn sepdej pda na_alpkn ^ej`ejc oepa ]j`
`ajoqna i]teiqi ^ekhkce_]h ]_perepu* Pda ]held]pe_ ^]_g^kja kb
`]ncejeja ]j` huoeja naoe`qao klpeieva hec]j` §beppejc· sepdej ]
`du`nkldk^e_ lk_gap ej pda na_alpkn* Kqn `]p] `aikjopn]pa pd]p
`]p pdaoa lkoepekjo ej chq_]ckj( jkjola_ebe_ du`nkldk^e_ ejpan)
`
`]_pekjo ]na ]o eilknp]jp ] _kjpne^qpejc b]_pkn pk ^ej`ejc ]bbej)
`epu ]o pda aha_pnkop]pe_ abba_po* Iqp]cajaoeo opq`eao kj pda
`na_alpkn d]ra kqpheja` pda laneiapan kb ] lqp]pera ^ej`ejc oepa
`^kn`ana` ^u jac]perahu _d]nca` naoe`qao* Pdqo( ]j kran]hh lko)
`eperahu _d]nca` chq_]ckj ikha_qha _kjpne^qpao pk pda op]^ehev])
`pekj kb pda dknikja)na_alpkn _kilhat ]j` oa_qnao pda ^ej`ejc
`_kjbkni]pekj pd]p oq^oamqajphu ha]`o pk ]_per]pekj*
`
`NABANAJ?AO
`
`-* Fahejag( H* F*( Hkg( O*( Nkoaj^anc( C* >*( Oiepd( N* =*( Cn]jp( B* F*( >ecco( O*(
`>ajo_d( L* =*( Gqeblan( F* H*( Odall]n`( L* K*( Olna_dan( ?* =*( K#D]n]( L* F*(
`Bkopan( @*( S]hgan( G* I*( ?daj( H* D* F*( I_ganj]j( L* =* " Gej`orkcah( S*
`$-55/% ;AGCKAC '*." -2-0 ®-2-2
`.* Oacna( C* R* " Ckh`nejc( O* N* $-55/% <NCKBO 0KBLANGKLI% 6CP?@% )" /,5 ®/-0
`/* Pdknajo( >* I* $-55.% 9NLA% 7?PI% ,A?B% ;AG% =% ;% ,% -." 420-® 4202
`0* Eoded]n]( P*( J]g]iqn]( O*( G]venk( U*( P]g]d]ode( P* P]g]d]ode( G* " J]c]p](
`O* $-55-% 06-8 5% &%" -2/1®-20-
`1* Qo`ej( P* >*( Iaoau( A*( >qppkj( @* ?*( >nksjopaej( I* F* " >kjjan( P* F* $-55/%
`0KBLANGKLILEU &((" .42-®.43,
`2* Eoded]n]( P*( Odecaikpk( N*( Ikne( G* " J]c]p]( O* $-55.% 7CQNLK -" 4--® 4-5
`3* Qjokj( ?* C*( I]_`kj]h`( @*( N]u( G*( @qnn]d( P* H* " Iannebeah`( N* >*