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`This is an Open Access article under the CC BY license.
`
`MYLAN EXHIBIT - 1015
`Mylan Pharmaceuticals, Inc. v. Bausch Health Ireland, Ltd. - IPR2022-00722
`
`

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`pd]p ^ej` uap `k jkp ]_per]pa ]`ajuhuh _u_h]oa*
`Pdeo opq`u kb pda aha_pnkop]pe_ ejpan]_pekj kb pda ^]oe_ naoe)
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``qao Huo ( =nc ( ]j` =nc
`kb chq_]ckj sepd ]_e`e_ naoe`qao kb
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`kn ]hh kb pdaoa cnkqlo i]u lnkre`a ] _kqjpanekj pk ] ola_ebe_
`]ol]npe_ ]_e` naoe`qa kj pda atpn]_ahhqh]n `ki]ej kb pda na_al)
`pkn pd]p d]o ^aaj odksj ej na_ajp iqp]cajaoeo opq`eao pk ^a
`_nepe_]h bkn hec]j` na_kcjepekj $-1( -4%* Pda eilknp]j_a kb deope)
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`^aaj benihu aop]^heoda` $5 ®-.%* Naikr]h kb pda deope`eja cnkql
`]bbkn`a` ]j ]j]hkc pd]p nap]eja` ]bbejepu bkn pda na_alpkn ^qp(
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`qh]pa` ]`ajuhuh _u_h]oa $5%* =hpdkqcd pda J)paniej]h deope`eja
`eo opne_phu _kjoanra` sepdej pda chq_]ckj b]iehu kb lalpe`a
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`18
`dknikjao( Huo ( =nc ( ]j` =nc
`]na nah]perahu qjemqa ]p
`pdaoa lkoepekjo ej chq_]ckj ]j` iecdp ]hok oanra ]o `apanie)
`j]jpo kb na_alpkn ola_ebe_epu*
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`q]pa` na_alpkn ^ej`ejc( ikop kb pda naoqhpejc ]j]hkco sana
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`pdaoa l]npe_qh]n lkoepekjo s]o jkp ]^okhqpahu _nepe_]h bkn ]_per)
`epu* Pd]p jk lkoeperahu _d]nca` ]iejk ]_e`o kb chq_]ckj( sepd
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`glpl HIAEG T F T SDV SSY L EGG A A KEF I AW LV KG R
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`Consensus HSDG T F T SD SR
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`pk `]pa s]o ,*41 $/2%*
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`pkhan]pa` ]p pdaoa lkoepekjo ]j` eil]ena` na_alpkn ^ej`ejc ^u ]
`dqj`na`)bkh` kn ikna* Opnkjchu na`q_a` ^ej`ejc ]bbejepeao sana
`_kqlha` sepd ]`ajuhuh _u_h]oa naolkjoao sepd iq_d sa]gaja`
`lkpaj_eao* Pdqo( ] lkoepera _d]nca ]p pdaoa lkoepekjo eo ja_ao)
`o]nu bkn klpei]h dknikj]h bqj_pekj*
`Kqn lnarekqo bej`ejco aop]^heoda` pda nkhao kb pda ]ol]npe_
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`_nepe_]h bkn pn]jo`q_pekj ^qp jkp bkn ^ej`ejc $3%( sdana]o pda
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`]hpan]pekj ej pda _d]nca `eopne^qpekj ]hkjc pda ikha_qha _ha]nhu
`naoqhpo ej `a_na]oa` ^ej`ejc kb pda `aner]perao* Qjhega lkoe)
`pekjo 5 ]j` -1 sdana pda lna_eoa hk_]pekj kb ]j ]ol]npe_ ]_e`
`naoe`qa eo _nepe_]h pk dknikja)na_alpkn ejpan]_pekj( ep ]lla]no
`pd]p chq_]ckj ^ej`ejc ]bbejepu eo jkp nacqh]pa` ^u pda pklk)
`cn]lde_ hk_]pekj kb ] ola_ebe_ lkoepera _d]nca ^qp ^u ] jap lko)
`epera _d]nca* =j kran]hh lkoeperahu _d]nca` ikha_qha `abejepahu
`ajd]j_ao pda ]bbejepu bkn epo iai^n]ja)^kqj` na_alpkn lnkpaej*
`= oejcha nalh]_aiajp ej chq_]ckj ]ie`a sepd ]j qj_d]nca`
`naoe`qa `e` jkp ]`amq]pahu ]hpan pda kran]hh _d]nca pk na`q_a
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`_d]nca` naoe`qa naoqhpa` ej ] jaqpn]h ikha_qha*
`Oa_napej( CHL)-( ]j` r]ok]_pera ejpaopej]h lalpe`a( chq_])
`ckj#o _hkoaop nah]perao sepdej pda b]iehu kb lalpe`a dknikjao(
`od]na 1,! oamqaj_a dkikhkcu ikophu ]p pda J)paniej]h d]hb kb
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`kb ^]oe_ naoe`qao o_]ppana` lnei]nehu ]hkjc pda ?)paniej]h l]np
`kb pdaoa oamqaj_ao ]na jkp sahh _kjoanra`* Ej ]j a]nhean nalknp(
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``qao kb chq_]ckj sana _ki^eja` sepd pda h]op -2 naoe`qao kb
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`jkni]h lalpe`ao kjhu ^ej` sa]ghu pk a]_d kpdan#o na_alpkn*
`Ejpanaopejchu( sd]p ]lla]no pk ^a lnaoanra` eo ]j kran]hh lkoe)
`pera _d]nca( oqccaopejc pd]p ] lkoeperahu _d]nca` hec]j` i]u ^a
`kja namqeoepa ba]pqna _kiikj pk iai^ano kb pdeo C lnkpaej)
`_kqlha` na_alpkn oq^)cnkql ]j` pdanabkna jkp ] opne_p `apanie)
`j]jp kb ola_ebe_epu*
`Pda opq`u ]hok nara]ho ] du`nkldk^e_epu _kilkjajp kb pda
`^ej`ejc ejpan]_pekj* Pda ^]oe_ ]iejk ]_e`o ]ncejeja ]j` huoeja
`_]j _kjpne^qpa jkp kjhu ] _d]nca` cnkql ^qp ]hok ]j ]held]pe_
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`^ej`ejc lk_gap* Pda lnklkoa` hec]j` ^ej`ejc oepa odkqh` hea
`sepdej ] du`nkldk^e_ _kna kb pda na_alpkn sdana jkjola_ebe_
`du`nkldk^e_ ejpan]_pekjo ^apsaaj pda dknikja ]j` epo na_alpkn
`ai^a``a` ej pda iai^n]ja ^eh]uan ]qciajp ^ej`ejc ]bbejepu*
`Pdeo atlh]ejo sdu oq^opepqpekj sepd ] jaqpn]h uap du`nkldk^e_
`ikha_qha hega ]h]jeja kn haq_eja s]o sahh pkhan]pa` `aolepa pda
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`]bbejepu bkn pda na_alpkn* = narano]h kb _d]nca kj pda kpdan d]j`
`]`ranoahu ]hpana` pda lkh]n _d]n]_pan kb pda lalpe`a ]j` ha` pk
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`]__kqjpa` bkn pda napajpekj kb oq^op]jpe]h ^ej`ejc ]bbejepu ]j`
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`oqlan]ckjeop sde_d ^kqj` 1)bkh` ^appan pd]j pda j]pqn]h dkn)
`ikja ]j` d]` ] decdan lkpaj_u $-5( .,%* = na_ajp t)n]u _nuop]h
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`araj sdaj du`nkldk^e_ naoe`qao ]na oq^opepqpa` bkn aepdan
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`^kpd pda lkh]n ]j` jkj)lkh]n ]ola_po kb pda lalpe`a ]j` lnkpaej
`ejpan]_pekjo pd]p k__qn sepdej pda na_alpkn ^ej`ejc oepa ]j`
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`]ncejeja ]j` huoeja naoe`qao klpeieva hec]j` §beppejc· sepdej ]
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`]p pdaoa lkoepekjo ej chq_]ckj( jkjola_ebe_ du`nkldk^e_ ejpan)
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`na_alpkn d]ra kqpheja` pda laneiapan kb ] lqp]pera ^ej`ejc oepa
`^kn`ana` ^u jac]perahu _d]nca` naoe`qao* Pdqo( ]j kran]hh lko)
`eperahu _d]nca` chq_]ckj ikha_qha _kjpne^qpao pk pda op]^ehev])
`pekj kb pda dknikja)na_alpkn _kilhat ]j` oa_qnao pda ^ej`ejc
`_kjbkni]pekj pd]p oq^oamqajphu ha]`o pk ]_per]pekj*
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`NABANAJ?AO
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