p Thu Sep 1 11:25:17 2005
`
`us-10-107-814-20.p2n.rge
`
`Page 1
`
`Copyright (c) 1993 - 2005 Compugen Ltd.
`
`GenCore version 5.1.6
`
`OM protein - nucleic search, using frame_plus_p2n model
`
`Run on:
`
`August 28, 2005, 09:48:36 ; Search time 2602 Seconds
`
`(without alignments)
`297.957 Million cell updates/sec
`
`Title:
`Perfect score: 95
`Sequence:
`
`US-10-107-814-20
`
`1 NDECELCVNVACTGCL 16
`
`Scoring table: BLOSUM62
`
`Xgapop 10.0 , Xgapext 0.5
`Ygapop 10.0 , Ygapext 0.5
`Fgapop 6.0 , Fgapext 7.0
`Delop 6.0 , Delext 7.0
`
`Searched:
`
`4708233 seqs, 24227607955 residues
`
`Total number of hits satisfying chosen parameters:
`
`9416466
`
`Minimum DB seq length: 0
`Maximum DB seq length: 2000000000
`
`Post-processing: Minimum Match 0%
`
`Maximum Match 100%
`Listing first 45 summaries
`
`Command line parameters:
`-MODEL=frame+_p2n.model -DEV=xlh
`-Q=/cgn2 1/USPTO spool/US10107814/runat 26082005 122651 15706/app_query.fasta 1.199
`-DB=GenEmbl -QFMT=fastap -SUFFIX=p2n.rg -MINMATC-B=0.1 -LOOPCL=0 -LOOPEXT=0
`-UNITS=bits -START=1 -END=-1 -MATRIX=blosum62 -TRANS=human40.cdi -LIST=45
`-DOCALIGN=200 -THR SCORE=pct -THR MAX=100 -THR MIN=0 -ALIGN=15 -MODE=LOCAL
`-OUTFMT=pto -NORM=ext -HEAPSIZE=500 -MINLEN=0 -MAXLEN=2000000000
`-USER=US10107814 @CGNl 1_4200 @runat 26082005 122651 15706 -NCPU=6 -ICPU=3
`-NO MMAP -LARGEQUERY -NEGSCORES=0 -WAIT -DSPBLOCK=100 -LONGLOG
`-DEV TIMEOUT=120 -WARNTIMEOUT=30 -THREADS=1 -XGAPOP=10 -XGAPEXT=0.5 -FGAPOP=6
`-FGAVEXT=7 -YGAPOP=10 -YGAPEXT=0.5 -DELOP=6 -DELEXT=7
`
`Database
`
`GenEmbl:*
`1: gb_ba:*
`2: gb_htg:*
`3: gb_in:*
`4: gb_om:*
`5: gb_ov:*
`6: gb_pat:*
`7: gb_ph:
`8: gb_pl:*
`9: gb_pr:*
`10: gb_ro:*
`11: gb_sts:*
`12: gb_sy:.,
`13: gb_un:"
`14: gb_vi:*
`
`Pred. No. is the number of results predicted by chance to have a
`score greater than or equal to the score of the result being printed,
`and is derived by analysis of the total score distribution.
`
`SUMMARIES
`
`Result
`
`No. Score
`
`Query
`Match Length DB ID
`
`1
`2
`3
`4
`
`92 96.8
`92 96.8
`92 96.8
`92 96.8
`
`72 6 A79703
`336 6 A79702
`414 9 BC069301
`583 6 A60251
`
`Description
`
`A79703 Sequence 37
`A79702 Sequence 36
`BC069301 Homo sapi
`A60251 Sequence 3
`
`RESULT 1
`A79703
`LOCUS
`DEFINITION Sequence 37 from Patent W09720049.
`ACCESSION A79703
`VERSION
`KEYWORDS
`SOURCE
`
`A79703.1 GI:6092631
`
`unidentified
`ORGANISM unidentified
`
`5
`6
`7
`8
`9
`10
`11
`12
`13
`14
`15
`16
`17
`18
`19
`20
`21
`22
`23
`c 24
`c 25
`c 26
`27
`28
`29
`30
`31
`32
`33
`34
`35
`36
`37
`c 38
`c 39
`40
`c 41
`42
`c 43
`44
`c 45
`
`92 96.8
`583 6 A79701
`583 9 HSGCAPII
`92 96.8
`92 96.8
`596 9 HSU34279
`92 96.8
`597 6 CQ720645
`92 96.8 3371 9 HSU55058
`92 96.8 3600 9 HSGCAP2
`92 96.8 141677 9 AC114492
`522 10 CPUGUMRNA
`90 94.7
`358 10 AF469496
`84 88.4
`526 10 RNU41322
`84 88.4
`548 10 RNU73898
`84 88.4
`84 88.4
`554 10 MMU67800
`590 10 MMU90727
`84 88.4
`605 10 BC024373
`84 88.4
`651 6 AX402024
`84 88.4
`651 10 RNU75186
`84 88.4
`84 88.4 3703 10 AF006668
`84 88.4 7274 10 MMU95182
`84 88.4 214456 10 AL645563
`84 88.4 217927 2 AL606911
`84 88.4 232814 2 BX324150
`84 88.4 243164 2 AC132173
`84 88.4 253902 2 AC095908
`472 4 SDGCAPII
`82 86.3
`77 81.1 1003 4 DVU49353
`920 5 AB080642
`73 76.8
`941 5 AAN301672
`73 76.8
`73 76.8 1037 5 AAN301673
`73 76.8 194209 5 BX248318
`67 70.5 1009 5 AB080640
`433 1 AF302048
`64 67.4
`62 6 AX252197
`63 66.3
`65 6 AX252193
`63 66.3
`63 66.3
`66 6 AX252196
`68 6 AX252192
`63 66.3
`69 6 AX252185
`63 66.3
`69 6 AX252188
`63 66.3
`69 6 AX252189
`63 66.3
`63 66.3
`72 6 AX252182
`72 6 AX252183
`63 66.3
`73 6 AX252184
`63 66.3
`
`ALIGNMENTS
`
`A79703
`
`72 bp
`
`DNA
`
`A79701 Sequence 35
`250753 H.sapiens m
`U34279 Human urogu
`C0720645 Sequence
`U55058 Human urogu
`270295 H.sapiens G
`AC114492 Homo sapi
`
`Z74738 C.porcellus
`AF469496 Notomys a
`U41322 Rattus nory
`U73898 Rattus nory
`U67800 Mus musculu
`U90727 Mus musculu
`BC024373 Mus muscu
`
`AX402024 Sequence
`
`U75186 Rattus nory
`AF006668 Mus muscu
`U95182 Mus musculu
`AL645563 Mouse DNA
`
`AL606911 Mus muscu
`BX324150 Mus muscu
`AC132173 Rattus no
`AC095908 Rattus no
`Z83746 S.domestica
`U49353 Didelphis v
`AB080642 Anguilla
`AJ301672 Anguilla
`AJ301673 Anguilla
`BX248318 Zebrafish
`AB080640 Anguilla
`AF302048 Vibrio mi
`AX252197 Sequence
`AX252193 Sequence
`AX252196 Sequence
`AX252192 Sequence
`AX252185 Sequence
`AX252188 Sequence
`AX252189 Sequence
`AX252182 Sequence
`AX252183 Sequence
`AX252184 Sequence
`
`linear PAT 20-OCT-1999
`
`REFERENCE 1 (bases 1 to 72)
`
`unclassified.
`
`AUTHORS Forssmann,W. and Kist,A.
`TITLE
`
`HUMAN PEPTIDE CIRCULATING IN THE BLOOD AND POSSESSING
`INSULINOTROPIC PROPERTIES
`
`JOURNAL Patent: WO 9720049-A 37 05-JUN-1997;
`
`FORSSMANN WOLF GEORG (DE); KIST ANDREAS (DE)
`
`FEATURES
`
`source
`
`ORIGIN
`
`Location/Qualifiers
`1. .72
`/organism="unidentified"
`/mol_type="unassigned DNA"
`/dbxref="taxon:32644"
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity: 93.75%
`
`1.05e-06
`92.00
`100.00%
`
`Length:
`Matches:
`Conservative: 1
`0
`Mismatches:
`
`72
`15
`
`L 4
`
`5
`
`Thu Sep
`
`1 11:25:17 2005
`
`Copyright (c)
`
`1993 - 2005
`
`Compugen Ltd.
`
`GenCore version 5.1.6
`
`OM protein - nucleic search, using frame_plus_p2n model
`
`Run on:
`
`August 28,
`
`2005, 09:48:36 ; Search time 2602 Seconds
`
`{without alignments)
`297.957 Million cell updates/sec
`
`Title:
`Perfect score:
`Sequence:
`
`US-10-107-814-20
`95
`1 NDECELCVNVACTGCL 16
`
`Scoring table:
`
`BLOSUM62
`Xgapop 10.0 , Xgapext
`Ygapop 10.0 , Ygapext
`Fgapop
`, Fgapext
`Delop
`, Delext
`
`6.0
`6.0
`
`0.5
`0.5
`7.0
`7.0
`
`Searched:
`
`4708233 segs, 24227607955 residues
`
`Total number of hits satisfying chosen parameters:
`
`9416466
`
`.
`
`Minimum DB seq length: 0
`Maximum DB seq length: 2000000000
`
`Post-processing: Minimum Match 0%
`
`Maximum Match 100%
`Listing first 45 summaries
`
`Command line parameters:
`-MODEL=frame+_p2n.model -DEV=xlh
`-Q=/cgn2_1/USPTO_spool/US10107814/runat_26082005_122651_15706/app_query.fasta_1.199
`-DB=GenEmbl -QFMT= fastap -SUFFIX=p2n.rge -MINMATCH=0.1 -~LOOPCL=0 -LOOPEXT=0
`-UNITS=bits -START=1 -END=-1 -MATRIX=blosumé2 -TRANS=human40.cdi -LIST=45
`-DOCALIGN=200 -THR_SCORE=pct -THR_MAX=100 -THR_MIN=0 -ALIGN=15 -MODE=LOCAL
`-OUTFMT=pto -NORM= ext -HEAPSIZE=500 -MINLEN=0 -MAXLEN=2000000000
`-USER=US10107814_@CGN_1_1 4200_@runat_26082005_122651_15706 -NCPU=6 -ICPU=3
`-NO_MMAP -LARGEQUERY “NEG_! SCORES=0 -WAIT -DSPBLOCK=100 -LONGLOG
`-DEV '_TIMEOUT=120 -WARN _TIMEOUT=30 -THREADS=1 -XGAPOP=10 -XGAPEXT=0.5 -FGAPOP=6
`-PGAPEXT=7 -YGAPOP=10 -YGAPEXT=0.S5 -DELOP=6 -DELEXT=7
`
`.
`
`Database :
`
`GenEmbl: *
`1:
`:
`:
`:
`:
`:
`:
`
`gb_ba:*
`gb_htg:*
`gb_ in:*
`gb_om:*
`gb_ov:*
`gb_pat: *
`gb_ph:+*
`
`Pred. No.
`score greater than or equal to the score of the result being printed,
`and is derived by analysis of the total score distribution.
`
`is the number of results predicted by chance to have a
`
`%
`
`SUMMARIES
`
`Score
`hh hE EE tal EE nt
`
`Description
`
`A79703 Sequence 37
`A79702 Sequence 36
`BC069301 Homo sapi
`A60251 Sequence 3
`
`
`
`Result
`No.
`
`EE
`
`Query
`Match Length DB
`
`ID
`
`92
`
`96.8
`
`72
`
`92
`
`96.8
`
`414
`
`6
`6
`9
`6
`
`A79703
`A79702
`BC069301
`A60251
`
`us-10-107-814-20.p2n.rge
`
`Page 1
`
`voo
`
`c
`c
`
`Cc
`
`c
`
`Cc
`
`5
`6
`7
`
`8
`9
`10
`11
`12
`13
`14
`is
`16
`17
`18
`19
`20
`21
`22
`23
`24
`
`92
`92
`92
`92
`92
`92
`92
`90
`84
`84
`84
`84
`84
`84
`84
`84
`84
`84
`84
`84
`
`~
`n
`
`©
`<
`
`26
`27
`28
`29
`30
`31
`32
`33
`34
`3s
`36
`37
`38
`39
`40
`41
`42
`43
`44
`45
`
`84
`84
`82
`77
`73
`73
`73
`73
`67
`64
`63
`63
`63
`63
`63
`63
`63
`63
`63
`63
`
`96.8
`583
`96.8
`583
`96.8
`596
`96.8
`597
`96.8
`371
`96.8
`600
`96.8 14
`677
`94.7
`S22
`88.4
`358
`526
`88.4
`88.4
`548
`88.4
`554
`88.4
`590
`88.4
`605
`651
`88.4
`88.4
`651
`3703
`88.4
`88.4
`7274
`88.4 214456
`88.4 217927
`88.4 232814
`88.4 243164
`88.4 253902
`86.3
`472
`1003
`81.1
`76.8
`920
`76.8
`941
`1037
`76.8
`76.8 194
`209
`1
`70.5
`009
`67.4
`4
`66.3
`66.3
`66.3
`66.3
`66.3
`66.3
`66.3
`66.3
`66.3
`66.3
`
`Vr ~
`WWW WW
`NN
`MmMANNWVWOOGN
`
`9
`
`Mme
`
`6
`9
`9
`6
`9
`9
`9
`10
`10
`10
`10
`10
`10
`10
`6
`10
`10
`10
`10
`
`
`
` NANI TNNNNWN DOW WIOW OY
`
`A79701
`HSGCAPII
`HSU34279
`C€Q720645
`HSUS5058
`HSGCAP2
`ACl114492
`
`CPUGUMRNA
`AF469496
`RNU41322
`RNU73898
`MMU67800
`MMU90727
`BC024373
`
`AX402024
`
`RNU75186
`AF006668
`MMU95182
`AL645563
`
`AL606911
`BX324150
`AC132173
`AC095908
`SDGCAPII
`DVU49353
`AB080642
`AAN301672
`AAN301673
`BX248318
`AB080640
`AF302048
`AX252197
`AX252193
`AX252196
`AX252192
`AX252185
`AX252188
`AX252189
`AX252182
`AX252183
`AX252184
`
`ALIGNMENTS
`
`A79701 Sequence 35
`250753 H.sapiens m
`U34279 Human urogu
`CQ720645 Sequence
`US5058 Human urogu
`270295 H.sapiens G
`AC114492 Homo sapi
`
`274738 C.porcellus
`AF469496 Notomys a
`U41322 Rattus norv
`U73898 Rattus norv
`U67800 Mus musculu
`U90727 Mus musculu
`BC024373 Mus muscu
`
`AX402024 Sequence
`
`U75186 Rattus norv
`AF006668 Mus muscu
`U95182 Mus musculu
`AL645563 Mouse DNA
`
`AL606911 Mus muscu
`BX324150 Mus muscu
`AC132173 Rattus no
`AC095908 Rattus no
`283746 S.domestica
`U49353 Didelphis v
`AB080642 Anguilla
`AJ301672 Anguilla
`AJ301673 Anguilla
`BX248318 Zebrafish
`AB080640 Anguilla
`AF302048 Vibrio mi
`AX252197 Sequence
`AX252193 Sequence
`AX252196 Sequence
`AX252192 Sequence
`AX252185 Sequence
`AX252188 Sequence
`AX252189 Sequence
`AX252182 Sequence
`AX252183 Sequence
`AX252184 Sequence
`
`RESULT 1
`A79703
`LOCUS
`DEFINITION
`ACCESSION
`VERSION
`KEYWORDS
`SOURCE
`
`ORGANISM
`
`REFERENCE
`AUTHORS
`TITLE
`
`JOURNAL
`
`FEATURES
`
`source
`
`ORIGIN
`
`Location/Qualifiers
`1.
`/organism="unidentified"
`/mol_type="unassigned DNA"
`/db_xref="taxon:32644"
`
`.72
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity:
`
`1.05e-06
`92.00
`100.00%
`93.75%
`
`Length:
`Matches:
`Conservative:
`Mismatches:
`
`72
`15
`1
`0
`
`A738703
`Sequence 37 from Patent W097200489.
`A79703
`A79703.1
`.
`unidentified
`unidentified
`unclassified.
`1
`Forssmann,W. and Kist,A.
`HUMAN PEPTIDE CIRCULATING IN THE BLOOD AND POSSESSING
`INSULINOTROPIC PROPERTIES
`Patent: WO 972004%-A 37 05-JUN-1997;
`FORSSMANN WOLF GEORG (DE); KIST ANDREAS (DE)
`
`72 bp
`
`DNA
`
`linear
`
`PAT 20-OCT-1999
`
`GI:6092631
`
`(bases 1 to 72)
`
`Pg.233
`
`MYLAN EXHIBIT - 1004 (Part 2)
`Mylan Pharmaceuticals, Inc. v. Bausch Health Ireland, Ltd. - IPR2022-00722
`
`

`

`Qy
`
`Db
`
`1 AsnAspGluCysGluLeuCysValAsnValAlaCysThrGlyCysLeu
`
`16
`
`25 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC
`
`I I I I I]:.: 11 I I I I I I I I1 I I I I I I I I I I I I I I I I I I I I I I I I I I I I
`
`72
`
`RESULT 2
`A79702
`LOCUS
`DEFINITION Sequence 36 from Patent WO9720049.
`ACCESSION A79702
`VERSION
`KEYWORDS
`SOURCE
`
`A79702
`
`A79702.1 GI:6092630
`
`unidentified
`ORGANISM unidentified
`
`336 bp
`
`DNA
`
`linear PAT 20-OCT-1999
`
`REFERENCE 1 (bases 1 to 336)
`
`unclassified.
`
`AUTHORS Forssmann,W. and Kist,A.
`TITLE
`
`HUMAN PEPTIDE CIRCULATING IN THE BLOOD AND POSSESSING
`INSULINOTROPIC PROPERTIES
`
`JOURNAL Patent: WO 9720049-A 36 05-JUN-1997;
`
`FORSSMANN WOLF GEORG (DE); KIST ANDREAS (DE)
`
`FEATURES
`
`source
`
`ORIGIN
`
`Location/Qualifiers
`1. .336
`/organism="unidentified"
`/mol_type="unassigned DNA"
`/dbxref="taxon:32644"
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity: 93.75%
`96.84%
`Query Match:
`DB:
`6
`
`4.71e-06
`92.00
`100.00%
`
`Length:
`Matches:
`Conservative: 1
`Mismatches:
`Indels:
`Gaps:
`
`0
`
`336
`15
`
`US-10-107-814-20 (1-16)
`
`x A79702 (1-336)
`
`Qy
`
`Db
`
`1 AsnAspGluCysGluLeu svalAsnvalAlaCysThrGl
`
`sLeu 16
`
`289 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC 336
`
`I I I I I I ::: I I I I I I I I I I ICy I I I I I I I I I I I I I I I I I I I I I I IyCyI I I I I
`
`RESULT 3
`BC069301
`LOCUS
`DEFINITION
`
`ACCESSION
`VERSION
`KEYWORDS
`SOURCE
`
`ORGANISM
`
`REFERENCE
`AUTHORS
`
`BC069301
`Homo sapiens guanylate cyclase activator 2B (uroguanylin), mRNA
`(cDNA clone MGC:97480 IMAGE:7262756), complete cds.
`BC069301
`BC069301.1 GI:47481402
`MGC.
`Homo sapiens (human)
`Homo sapiens
`Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
`Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
`1 (bases 1 to 414)
`Strausberg,R.L., Feingold,E.A., Grouse, L.H., Derge,J.G.,
`Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
`Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
`Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
`Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
`Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
`Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
`Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
`Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
`McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
`Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
`Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
`Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
`Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
`
`414 bp
`
`mRNA
`
`linear PRI 30-JUN-2004
`
`REMARK
`
`COMMENT
`
`Gene Collection (MGC), Cancer Genomics Office, National Cancer
`Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
`USA
`NIH-MGC Project URL: http://mgc.nci.nih.gov
`Contact: MGC help desk
`Email: cgapbs-r@mail.nih.gov
`Tissue Procurement: Baylor Human Genome Sequencing Center
`cDNA Library Preparation: Baylor Human Genome Sequencing Center
`cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
`DNA Sequencing by: Baylor College of Medicine Human Genome
`Sequencing Center
`Center code: BCM-HGSC
`Web site: http://www.hgsc.bcm.tmc.edu/cdna/
`Contact: amg@bcm.tmc.edu
`Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Louleeged, H.,
`Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
`A.N., Gibbs, R.A.
`
`PUBMED 12477932
`
`REFERENCE 2 (bases 1 to 414)
`
`AUTHORS Strausberg,R.
`TITLE
`JOURNAL Submitted (29-APR-2004) National Institutes of Health, Mammalian
`
`Direct Submission
`
`Clone distribution: MGC clone distribution information can be found
`through the I.M.A.G.E. Consortium/LLNL at: http://image.11nl.gov
`Series: IRBR Plate: 7 Row: h Column: 6.
`
`FEATURES
`
`source
`
`gene
`
`CDS
`
`Location/Qualifiers
`1. .414
`/organism="Homo sapiens"
`/mol_type="mRNA"
`/db_xref="taxon:9606"
`/clone="MGC:97480 IMAGE:7262756"
`/tissue_type="PCR rescued clones"
`/clone lib="NIH MGC_244"
`/note=7 Vector: pPCR-Script Amp SK(+)"
`1. .414
`/gene="GUCA2B"
`/note="synonyms: GCAP-II, UGN"
`/db_xref="LocusID:2981"
`/db_xref="MIM:601271"
`29. .367
`/gene="GUCA2B"
`/codon_start=1
`/product="guanylate cyclase activator 2B (uroguanylin)"
`/protein_id="AAH69301.1"
`/db xref="GI:47481403"
`/db:xref="LocusID:2981"
`/dbxref="MIM:601271"
`/translation="MGCRAASGLLPGVAVVLLLLLOSTQSVYIQYOGFRVQLESMKKL
`SDLEAQWAPSPRLQAQSLLPAVCHHPALPQDLQPVCASQFASSIFKTLRTIANDDCEL
`CVNVACTGCL"
`
`ORIGIN
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity: 93.75%
`96.84%
`Query Match:
`DB:
`9
`
`5.77e-06
`92.00
`100.00%
`
`Length:
`Matches:
`Conservative: 1
`Mismatches:
`Indels:
`Gaps:
`
`0
`
`414
`15
`
`US-10-107-814-20 (1-16)
`
`x BC069301 (1-414)
`
`Qy
`
`Db
`
`317 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC
`
`364
`
`1 AsnAspGluCysGluLeuCysValAsnValAlaCysThrGlyCysLeu
`I I I I I I :.' I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I1 I I I I I I
`
`16
`
`Thu Sep 1 11:25:17 2005
`
`us-10-107-814-20.p2n.rge
`
`Page 2
`
`Query Match:
`DB:
`
`96.84%
`6
`
`Indels:
`Gaps:
`
`0
`0
`
`US-10-107-814-20 (1-16) x A79703 (1-72)
`
`TITLE
`
`JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
`
`Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green, E.D.,
`Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
`Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
`Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
`Generation and initial analysis of more than 15,000 full-length
`human and mouse cDNA sequences
`
`Query Match:
`DB:
`
`96.84%
`6
`
`Indels:
`Gaps:
`
`[Xe
`
`UsS-10-107-8
`
`14-20 (1-16) x A79703 (1-72)
`
`1 AsnAs st rR Rn 16
`
`Db
`
`25 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC 72
`
`RESULT 2
`A79702
`LOCUS
`DEFINITION
`ACCESSION
`VERSION
`KEYWORDS
`SOURCE
`
`ORGANISM
`
`REFERENCE
`AUTHORS
`TITLE
`
`JOURNAL
`
`FEATURES
`
`source
`
`ORIGIN
`
`A79702
`Sequence 36 from Patent W09720049.
`A79702
`A79702.1
`
`GI:6092630
`
`336 bp
`
`DNA
`
`linear
`
`PAT 20-OCT-1999
`
`unidentified
`unidentified
`unclassified.
`1
`Porgsmann,W. and Kist,A.
`HUMAN PEPTIDE CIRCULATING IN THE BLOOD AND POSSESSING
`INSULINOTROPIC PROPERTIES
`Patent: WO 9720049-A 36 05-JUN-1997;
`FORSSMANN WOLF GEORG (DE); KIST ANDREAS (DE)
`
`(bases 1
`
`to 336)
`
`Location/Qualifiers
`1.
`/organism="unidentified"
`/mol_type="unassigned DNA"
`/db_xref="taxon:32644"
`
`.336
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Sim
`Best Local Similarity:
`Query Match:
`DB:
`
`ilarity:
`
`4.71le-06
`92.00
`100.00%
`93.75%
`96.84%
`6
`
`Length:
`Matches:
`Conservative:
`Mismatches:
`Indels:
`Gaps:
`
`336
`15
`1
`0
`0
`0
`
`-10-107-8
`
`14-20
`
`(1-16) x A79702 (1-336)
`
`1 AsnAspGluCysGluLeu RRR 16
`
`Db
`
`289 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC 336
`
`
`
`
`RESULT 3
`BC069301
`LOCUS
`DEFINITION
`
`ACCESSION
`VERSION
`KEYWORDS
`SOURCE
`
`ORGANISM
`
`REFERENCE
`AUTHORS
`
`BC069301
`Homo sapiens guanylate cyclase activator 2B {(uroguanylin), mRNA
`(cDNA clone MGC:97480 IMAGE:7262756), complete cds.
`BC069301
`BC069301.1
`MGC.
`Homo sapiens (human)
`Homo sapiens
`Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
`Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
`1
`Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
`Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
`Altschul ,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
`Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
`Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
`Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
`Scheetz, T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
`Carninci, P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
`Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
`McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
`Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
`villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
`Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
`Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
`
`GI:47481402
`
`(bases 1
`
`to 414)
`
`414 bp
`
`MRNA
`
`linear
`
`PRI 30-JUN-2004
`
`
`
`
`Qy
`
`Db
`
`Thu Sep
`
`1 11:25:17 2005
`
`us-10-107-814-20.p2n.rge
`
`Page 2
`
`TITLE
`
`JOURNAL
`PUBMED
`REFERENCE
`AUTHORS
`TITLE
`JOURNAL
`
`REMARK
`
`COMMENT
`
`FEATURES
`
`source
`
`gene
`
`CDS
`
`Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
`Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
`Butterfield,Y.S.,
`Schnerch,A., Schein, J.E., Jones, Ss. J. and Marra,M.A.
`Generation and initial analysis of more than 15,000 full-length
`human and mouse CDNA sequences
`Proc. Natl. Acad. Sci. U.S.A. 99
`12477932
`2
`Strausberg, R.
`Direct Submission
`Submitted (29-APR-2004) National Institutes of Health, Mammalian
`Gene Collection (MGC), Cancer Genomics Office, National Cancer
`Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
`USA
`NIH-MGC Project URL: http://mgc.nci.nih.gov
`Contact: MGC help desk
`Email: cgapbs-r@mail.nih.gov
`Tissue Procurement: Baylor Human Genome Sequencing Center
`cDNA Library Preparation: Baylor Human Genome Sequencing Center
`CDNA Library Arrayed by: The I.M.A.G.E. Consortium ({(LLNL)
`DNA Sequencing by: Baylor College of Medicine Human Genome
`Sequencing Center
`Center code: BCM-HGSC
`Web site: http://www.hgsc.bcm.tme.edu/cdna/
`Contact: amg@bcm.tmc.edu
`Gunaratne, P.H., Garcia, A.M.,
`Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
`A.N., Gibbs, R.A.
`
`Lu,
`
`X., Hulyk, S.W., Loulseged, H.,
`
`Clone distribution: MGC clone distribution information can be found
`through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
`Series: IRBR Plate: 7 Row:
`
`h Column: 6.
`
`Location/Qualifiers
`1.
`/organism="Homo sapiens"
`/mol_type="mRNA"
`/db_xref="taxon:9606"
`/clone="MGC:97480 IMAGE:7262756"
`/tissue_type="PCR rescued clones"
`/clone_ Tib="NIH_| MGC_244"
`/note="Vector: pPCR-Script Amp SK(+)}"
`1.
`/gene="GUCA2B"
`/note="synonyms: GCAP-II, UGN"
`/db_xref="LocusID:2981"
`/db_xref="MIM:601271"
`29.
`/gene="GUCA2B"
`/codon_start=1
`/product="guanylate cyclase activator 2B (uroguanylin}®
`/protein_id="AAH69301.1"
`/db_xref="GI:47481403"
`/db_xref="LocusID:2981"
`/db xref="MIM: 601271"
`/translation="MGCRAASGLLPGVAVVLLLLLQSTQSVYIQYQGFRVQLESMKKL
`SDLEAQWAPSPRLQAQSLLPAVCHHPALPQDLQPVCASQEASSIFKTLRTIANDDCEL
`CVNVACTGCL"
`
`.414
`
`.414
`
`.367
`
`Krzywinski,M.I.
`
`skalska, u., Smailus, D.E.,
`
`(bases 1
`
`to 414)
`
`(26), 16899-16903 (2002)
`
`ORIGIN
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity:
`Query Match:
`DB:
`
`5.77e-06
`92.00
`100.00%
`93.75%
`96.84%
`9
`
`Length:
`Matches:
`Conservative:
`Mismatches:
`Indels:
`Gaps:
`
`414
`15
`1
`0
`0
`0
`
`US-10-107-814-20 (1-16)
`
`x BC069301 (1-414)
`
`317 JUURNURAGANERT RNA IRAN RRT IVY IRERVRAIINPTIRAINELLY. 364
`
`nn
`
`PETTITT YE TTY
`nEnnnnn nn
`
`I
`
`
`
`
`Pg.234
`
`

`

`Thu Sep 1 11:25:17 2005
`
`us-10-107-814-20.p2n.rge
`
`Page 3
`
`RESULT 4
`A60251
`LOCUS
`DEFINITION Sequence 3 from Patent WO9706258.
`ACCESSION A60251
`VERSION
`KEYWORDS
`SOURCE
`
`A60251.1 GI:3715256
`
`unidentified
`ORGANISM unidentified
`
`A60251
`
`583 bp
`
`REFERENCE 1
`
`unclassified.
`
`AUTHORS
`
`TITLE
`
`Forssmann,W., Hill,O., Hess,R., Adermann,K., Raida,M., Maegert,H.,
`Meyer,M. and Schulz-Knappe,P.
`cDNA SEQUENCE, AMINO-ACID SEQUENCE, DERIVED FROM THE cDNA SEQUENCE,
`OF THE PRECURSOR PROTEIN OF HUMAN GCAP-II/UROGUANYLINE, AND
`AMINO-ACID SEQUENCE OF THE FRAGMENT CIRCULATING IN HUMAN BLOOD
`
`JOURNAL Patent: WO 9706258-A 3 20-FEB-1997;
`
`COMMENT
`FEATURES
`
`source
`
`ORIGIN
`
`FORSSMANN WOLF GEORG (DE)
`Other publication DE 19528544 970206.
`
`Location/Qualifiers
`1. .583
`/organism="unidentified"
`/mol type="unassigned DNA"
`/dbTcref="taxon:32644"
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity:
`Query Match:
`DB:
`
`8.07e-06
`92.00
`100.00%
`93.75%
`96.84%
`6
`
`Length:
`Matches:
`Conservative: 1
`0
`Mismatches:
`Indels:
`0
`Gaps:
`0
`
`583
`15
`
`US-10-107-814-20 '(1-16)
`
`x A60251 (1-583)
`
`Qy
`
`Db
`
`1 AsnAspGluCysGluLeuCysValAsnValAlaCysThrGlyCysLeu
`
`16
`
`310 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC
`
`I I I I I I ::: I I I I I I I I I I1 I I I I I I I I I I I I I II I I I I I I I I I I I I I
`
`357
`
`RESULT 5
`A79701
`LOCUS
`DEFINITION Sequence 35 from Patent W09720049.
`ACCESSION A79701
`VERSION
`KEYWORDS
`SOURCE
`
`A79701.1 GI:6092629
`
`unidentified
`ORGANISM unidentified
`
`A79701
`
`583 bp
`
`DNA
`
`linear PAT 20-OCT-1999
`
`REFERENCE 1 (bases 1 to 583)
`
`unclassified.
`
`AUTHORS Forssmann,W. and Kist,A.
`TITLE
`
`HUMAN PEPTIDE CIRCULATING IN THE BLOOD AND POSSESSING
`INSULINOTROPIC PROPERTIES
`
`JOURNAL Patent: WO 9720049-A 35 05-JUN-1997;
`
`FORSSMANN WOLF GEORG (DE); KIST ANDREAS (DE)
`
`FEATURES
`
`source
`
`ORIGIN
`
`Location/Qualifiers
`1. .583
`/organism="unidentified"
`/mol type="unassigned DNA"
`/dbRref="taxon:32644"
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity:
`Query Match:
`DB:
`
`8.07e-06
`92.00
`100.00%
`93.75%
`96.84%
`6
`
`Length:
`Matches:
`Conservative: 1
`0
`Mismatches:
`0
`Indels:
`0
`Gaps:
`
`583
`15
`
`US-10-107-814-20 (1-16)
`
`x A79701 (1-583)
`
`DNA
`
`linear PAT 06-MAR-1998
`
`Qy
`
`Db
`
`1 AsnAspGluCysGluLeuCysValAsnValAlaCysThrGlyCysLeu 16
`
`310 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC 357
`
`RESULT 6
`HSGCAPII
`LOCUS
`DEFINITION H.sapiens mRNA for GCAP-II/uroguanylin precursor.
`ACCESSION Z50753
`VERSION
`KEYWORDS
`SOURCE
`
`HSGCAPII
`
`583 bp
`
`mRNA
`
`linear PRI 09-SEP-2004
`
`250753.1 GI:974823
`GCAP-II; uroguanylin.
`Homo sapiens (human)
`
`ORGANISM Homo sapiens
`
`Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
`Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
`
`REFERENCE 1 (bases 1 to 583)
`
`AUTHORS Hill,O., Cetin,Y., Cieslak,A., Magert,H.J. and Forssmann,W.G.
`TITLE
`
`A new human guanylate cyclase-activating peptide (GCAP-II,
`uroguanylin): precursor cDNA and colonic expression
`
`JOURNAL Biochim. Biophys. Acta 1253 (2), 146-149 (1995)
`MEDLIN& 96106424
`
`PUBMED 8519795
`
`REFERENCE 2 (bases 1 to 583)
`
`AUTHORS Hill,O.
`TITLE
`JOURNAL Submitted (04-AUG-1995) Oliver Hill, Molecular Biology, Lower
`
`Direct Submission
`
`Saxony Institute for Peptide, Research, Feodor-Lynen-Strasse 31,
`Hannover, Lower Saxon, 30625, Germany
`
`FEATURES
`
`source
`
`5'UTR
`
`CDS
`
`3'UTR
`polyA_signal
`
`ORIGIN
`
`Location/Qualifiers
`1. .583
`/organism="Homo sapiens"
`/mol_type="mRNA"
`/db_xref="taxon:9606"
`/clone="pC515, pl6R106, pl8R106"
`/tissue_type="colon"
`/clone_lib="3'-RACE and 5'-RACE PCR products"
`/dev_stage="adult"
`1. .21
`/note="determined by consensus rules"
`22. .360
`/note="determined by sequence comparison"
`/codon_start=1
`/product="GCAP-II/uroguanylin precursor"
`/protein_id="CAA90629.1"
`/db_xref="GI:974824"
`/dbxref="GOA:Q16661"
`/dbxref="UniProt/Swiss-Prot:016661"
`/translation="MGCRAASGLLPGVAVVLLLLLOSTOSVYIQYQGFRVQLESMKKL
`SDLEAQWAPSPRLQAQSLLPAVCHHPALPODLOPVCASQEASSIFKTLRTIANDDCEL
`CVNVACTGCL"
`361. .583
`567. .572
`/note="determined by consensus rules"
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity: 93.75%
`96.84%
`Query Match:
`9
`DB:
`
`8.07e-06
`92.00
`100.00%
`
`Length:
`Matches:
`Conservative: 1
`0
`Mismatches:
`0
`Indels:
`0
`Gaps:
`
`583
`15
`
`US-10-107-814-20 (1-16) x HSGCAPII (1-583)
`
`Qy
`
`Db
`
`1 AsnAspGluCysGluLeuCysValAsnValAlaCysThrGlyCYsLeu 16
`
`310 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC 357
`
`I I I I I I ::: I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I I1I I I I
`
`RESULT 7
`HSU34279
`LOCUS
`
`HSU34279
`
`596 bp
`
`mRNA
`
`linear PRI 28-MAR-1996
`
`~
`
`*”
`
`Thu Sep
`
`1 11:25:17 2005
`
`RES
`A602
`LO
`DEF1
`ACCESSION
`VERSION
`KEYW!
`SOUR
`
`ULT 4
`
`51
`
`Cus
`
`NITION
`
`ORGANISM
`
`ORDS
`CE
`
`A60251
`Sequence 3 from Patent W09706258.
`A60251
`A60251.1
`
`GI:3715256
`
`583 bp
`
`REFE
`
`RENCE
`AUTHORS
`
`TITLE
`
`JOURNAL
`
`COMMENT
`FEATURES
`
`source
`
`ORIGIN
`
`Location/Qualifiers
`1.
`/organism="unidentified"
`/mol_type="unassigned DNA"
`/db_xref="taxon:32644"
`
`.583
`
`Ali
`Pred
`?
`Score:
`Perc
`Best
`Query
`D
`
`ent Similarity:
`
`Local Similarity:
`
`Match:
`
`B:
`
`gnment Scores:
`
`. No.:
`
`8.07e-06
`92.00
`100.00%
`93.75%
`96.84%
`6
`
`us
`
`10-107-814-20 (1-16) x A60251 (1-583)
`
`Qy
`
`D.
`
`[11H
`
`ELLER
`
`EEL
`
`R
`A7
`held
`DEFINITION
`ACCE
`VER
`KE
`SOUR CE
`
`soot 5
`
`701
`
`S
`
`SSION
`
`SION
`
`YWORDS
`
`ORGANISM
`
`REFE
`
`RENCE
`AUTHORS
`TITLE
`
`JOURNAL
`
`F
`
`EATURES
`
`source
`
`ORIGIN
`
`583
`
`bp
`
`GI:6092629
`
`(bases 1
`
`to 583)
`
`Location/Qualifiers
`1.
`/organism="unidentified"
`/mol_type="unassigned DNA"
`/db_: Xref="taxon:32644"
`
`.583
`
`Ali
`Pred
`Score
`Per
`Best
`Query
`DB:
`
`gnment Scores:
`
`. No.:
`
`cent Similarity:
`
`Local Similarity:
`
`Match:
`
`8.07e-06
`92.00
`100.00%
`93.75%
`96.84%
`6
`
`us-
`
`10-107-814-20 (1-16) x A79701 (1-583)
`
`us-10-107-814-20.p2n.rge
`
`Page 3
`
`DNA
`
`linear
`
`PAT 06-MAR-1998
`
`unidentified
`unidentified
`unclassified.
`1
`Forssmann,W., Hill,O0., Hess,R., Adermann,K., Raida,M., Maegert,H.,
`Meyer,M. and Schulz-Knappe,P.
`CDNA SEQUENCE, AMINO-ACID SEQUENCE, DERIVED FROM THE cDNA SEQUENCE,
`OF THE PRECURSOR PROTEIN OF HUMAN GCAP-II/UROGUANYLINE, AND
`AMINO-ACID SEQUENCE OF THE FRAGMENT CIRCULATING IN HUMAN BLOOD
`Patent: WO 9706258-A 3 20-FEB-1997;
`FORSSMANN WOLF GEORG (DE)
`Other publication DE 19528544 970206.
`
`Length:
`Matches:
`Conservative:
`Mismatches:
`Indels:
`Gaps:
`
`583
`15
`1
`0
`0
`0
`
`Qy
`
`Db
`
`RESULT 6
`HSGCAPII
`LOCUS
`DEFINITION
`ACCESSION
`VERSION
`KEYWORDS
`SOURCE
`
`ORGANISM
`
`REFERENCE
`AUTHORS
`TITLE
`
`JOURNAL
`MEDLINE
`PUBMED
`REFERENCE
`AUTHORS
`TITLE
`JOURNAL
`
`310 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC 357
`
`ELE EEE
`
`TE
`
`1 TN ART sValAsnvalAlal Rtn 16
`
`A79701
`Sequence 35 from Patent W09720049.
`A79701
`A79701.1
`.
`unidentified
`unidentified
`unclassified.
`1
`Forssmann,W. and Kist, A.
`HUMAN PEPTIDE CIRCULATING IN THE BLOOD AND POSSESSING
`INSULINOTROPIC PROPERTIES
`Patent: WO 9720049-A 35 05-JUN-1997;
`FORSSMANN WOLF GEORG (DE); KIST ANDREAS (DE)
`
`DNA
`
`linear
`
`PAT 20-OCT-1999
`
`Length:
`Matches:
`Conservative:
`Mismatches:
`Indels:
`Gaps:
`
`583
`15
`1
`0
`0
`0
`
`linear
`HSGCAPII
`H.sapiens mRNA for GCAP-II/uroguanylin precursor.
`250753
`250753.1
`GCAP-II; uroguanylin.
`Homo sapiens (human)
`Homo sapiens
`Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
`Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
`1
`Hill,0., Cetin,Y., Cieslak,A., Magert,H.J. and Forssmann,W.G.
`A new human guanylate cyclase-activating peptide (GCAP-II,
`uroguanylin): precursor cDNA and colonic expression
`Biochim. Biophys. Acta 1253
`96106424
`8519795
`2
`Hill, oO.
`Direct Submission
`Submitted (04-AUG-1995) Oliver Hill, Molecular Biology, Lower
`Saxony Institute for Peptide, Research, Feodor-Lynen-Strasse 31,
`Hannover, Lower Saxon, 30625, Germany
`
`583 bp
`
`mRNA
`
`PRI 09-SEP-2004
`
`GI:974823
`
`(bases 1
`
`to 583)
`
`(2), 146-149 (1995)
`
`(bases 1 to 583)
`
`
`
`
`FEATURES
`
`source
`
`S’UTR
`
`CDS
`
`3’UTR
`polyA_signal
`
`ORIGIN
`
`Location/Qualifiers
`1.
`/organism="Homo sapiens"
`/mol_type="mRNA"
`/db_xref="taxon:9606"
`/clone="pC515, pl6R106, plBR106"
`/tissue_type="colon"
`/clone_1ib="3’-RACE and 5'-RACE PCR products"
`/dev_stage="adult"
`1.
`/note="determined by consensus rules"
`22.
`/note="determined by sequence comparison"
`/codon_start=1
`/product="GCAP-I1/uroguanylin precursor"
`/protein_id="CAA90629.1"
`/db_: xref="GI:974824"
`/db_. xref="GOA:Q16661"
`/db_xref="UniProt/Swiss-Prot:Q16661"
`/translations"MGCRAASGLLPGVAVVLLLLLQSTQSVYIQYQGFRVQLESMKKL
`SDLEAQWAPSPRLQAQSLLPAVCHHPALPQDLQPVCASQEASSIFKTLRTIANDDCEL
`CVNVACTGCL"
`.583
`361.
`567. .572
`/note="determined by consensus rules"
`
`.21
`
`.360
`
`.583
`
`Alignment Scores:
`Pred. No.:
`Score:
`Percent Similarity:
`Best Local Similarity:
`Query Match:
`DB:
`
`\
`
`8.07e-06
`92.00
`100.00%
`93.75%
`96.84%
`9
`
`Length:
`Matches:
`Conservative:
`Mismatches:
`Indels:
`Gaps:
`
`583
`15
`1
`0
`0
`0
`
`US-10-107-814-20 (1-16)
`
`x HSGCAPII (1-583)
`
`Qy
`
`Db
`
`RESULT 7
`HSU34279
`LOCUS
`
`YT TT TT 16
`310 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC 357
`
`1 A
`ese
`
`POLED
`
`LOLLELELTEL LEELA EET dL
`
`HSU34279
`
`596 bp
`
`mRNA
`
`linear
`
`PRI 2B8-MAR-1996
`
`1 ST RNY TTT 16
`
`310 AACGACGACTGTGAGCTGTGTGTGAACGTTGCGTGTACCGGCTGCCTC 357
`
`FIVE
`
`i
`esa
`
`d ETE DT FILELLEEL
`
`Pg.235
`
`

`

`Thu Sep 1 11:25:17 2005
`
`DEFINITION Human uroguanylin mRNA, complete cds.
`ACCESSION U34279
`VERSION
`KEYWORDS
`SOURCE
`
`U34279.1 GI:1236798
`
`Homo sapiens (human)
`
`ORGANISM Homo sapiens
`
`Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
`Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
`
`REFERENCE 1 (bases 1 to 596)
`
`AUTHORS Miyazato,M., Nakazato,M., Yamaguchi,H., Date,Y., Kojima,M.,
`
`TITLE
`
`Kangawa,K., Matsuo,H. and Matsukura,S.
`Cloning and characterization of a cDNA encoding a precursor for
`human uroguanylin
`
`JOURNAL Biochem. Biophys. Res. Commun. 219 (2),
`MEDLINE 96193705
`
`644-648 (1996)
`
`PUBMED 8605041
`
`REFERENCE 2 (bases 1 to 596)
`
`AUTHORS Miyazato,M.
`TITLE
`JOURNAL Submitted (17-AUG-1995) Mikiya Miyazato, Biochemistry, National
`
`Direct Submission
`
`Cardiovascular Center Research Institute, Fujishirodai, Suita,
`Osaka 565, Japan
`
`FEATURES
`
`source
`
`CDS
`
`Location/Qualifiers
`1. .596
`/organism="Homo sapiens"
`/mol type="mRNA"
`/db_Rref="taxon:9606"
`30. .368
`/codon start=1
`/produa="uroguanylin"
`/protein_i