... •
`
`rn:11w 1-;vpm, of dls.,p(,l'~t•<l 1.1111>11t onern, 1111d iK r111 1:lfodivo HI nhil iw r fon(cid:173)
`oil, in ,wol\H' u11,11lniot1t,.
`'l"htm.111•.n1lic:11lly, ii. i,, 1,1111,:<I ,1,, 1,1 /111/11 lt1,rnt.i111• i11 1.lw tn,11111111111 ol'
`cl,m,,i,, 11fJ/1~1.i1;vt.ivn , 'J'11k1,11 wi s.11 J or 21{1,11)t1(1,1f11l of'wn1~ir, It. l'm•111:•
`11,:olluidnl ,. .. 1111.iou in t.lw 1111111,r nlh111,11t111·y 1.1•11111; t.hi<i iu1h1tirm l,.,,c:•
`w11l.,ir in ~hi! c.olo11, fonnin1,1,q;,:11.h111. inr:n,11111!11 t.11<1 hu ll, "'"l 11ofl11e!J~
`'l'hr. f!Ol i1, h lnnil, d1,11111lconl 1111d 11,111irr'ilnl.in1: In t,h,)
`11f 1.lw «tool.
`f(t1r11.1·11i11H:r<(,i1111I lrncl.. Om:11 11 non,1111 11(0,1! d«1•<:lop11.
`th<! dn•t>
`~hcmhl hn r111luc:11fl 1.,1 t1 l,1v,1I 11,k<pllll.1! J',w 11111i111m1r111c1i ,11' fi(1orl
`l\1llcl.io11. All.h••ll1(l1 ii-(.,1lw, 1111 w11t.1:r r,•<11111.h,: y.11,1t.1\1i11l<mlhtnl U·uc!I.
`1111it.1: ri,i1dil_v, 11wt,h)lk11ll11lnk11 lnh lu1K l1r.1v,• ,;01.11mcl f,,,:111 im111wt i1111
`,rnd i,1t,c,i,l,i11nl ,1ha1.1·1wl.io11 wla,11 1-nltNI wi l,h ,1 limil.(,d 11111(111111. of
`w11tur. l l :1lsn is 11110<1 n11 11 t.<1pkal 1Jph1,h11l111 i-, p,·nl"t:l.11111., in I-Im fnrm
`of O.li t.o 1% r1oh1t.i1111 r.o1·vi111: 11K 11rt.ifki11 I h•un, or 11 1·•111hwl• k,1H,
`(«1l\l\in 11 npplii!d lo tlu.• mnj11nd.iv11, 1l.O!, In(), I mL JI!. 11 l.im(:, ;I or •I
`1.i111r8 11 dra~• nn t\<>l)tlc,I.
`n11• 0 .. , ... IJ~11a/, /1N luxnl,ivv, I IA> I .II r,, with wn1.nr, ;I, l{I •t 1.i111cm n clny.
`'l'11lil<>I":
`1101) m11; l)p hthn lmi,: 8nl111.inn: 0,!i
`Do,mt(u 1"tn·nm
`111,d l't..,; .'~yl'\ti,; !i.ll l 1:/:tll ml..
`
`Octoxynol O
`
`r(ly~ol 111011111;1•·( I, 1,a,:•l•Wl,r1m1r.th)•lh11t.yl)ph,myl)
`l'olyulh~•hme
`1:1.lwr l!l002- !l:l -l]: 11111111hyd1·1\II~ li(luid mi~l-lll't> of lll<m•>·J)"(J, 1,:1,:1-
`I.N,1·(1111<!lhylh11 l.~l)1•ho11yl ol-h,m, of p,1l_vc.U1yl,!1ll> 1ilyMlri iu whii:.h 11
`vmiou from /i ' " I(",, 111111 which h,1. mi ,1vm·11g1? mol~c:1,l11r wo•IJ/111 or
`(H'l, Ml'l'"Kl'llluli11,: to 1.h,, J',mm1l11C,~J-l,;:,011,
`l',·11111u·ul,iilll .. ,. By r1!11c\i t11( 11-( I ,I ,!I,:,, l•)U·m1111\,hyllml-~•1)11lurnol
`wit.h ~t.h,1•l,m11 ,1~ itltf nt. u1<,v1\tod u,mporata.irn 111"\ur 1n'cil11111r,) i,1 1.h,,
`1>ro•"ncc: of N,1()1-1.
`J)~,;crh>tlou-.... CJ,•nr, pnt,, ~•(,UO\\•'. vh\,~fH1r; li,1uid. h,,,,iun n f11lnf odor
`rnltl II hill lll' 111~1,:; ~1 •1:11ifi1'. 1:ri1\'il,y ,1lmul l ,()fi,\; \Ill (I in 100 11•111,1<>11"
`,1,1lu1io11l 11h1111I-'I.
`Sol11hlliiy ...... Mi,1:il>lv with watltr, nlcrJhol or 111:.,111111!; 1,11l11hlt• 111 b1111•
`Y.1.'0C\ or toltu:)W~ in~dh1hlf• in t,;olvtmt. lwxnnc,
`
`I IHc<11•-··A n<111ionk d1!(r1ry,cm1., <:m11l,1irior ,mcl 11i11p!!r11ln11 n1c1,11t. II
`i~an in1!l'tH1itml in Nitr,,[11N1,-,1,1<' S11/111im1. He<: /"£,/y1!/l1ylcmr! 01,v·
`('.11/ ,WO (pHrio 1:11:I).
`
`Olt1yl Alcohol
`
`11-<'l1•11u.lcc1m· I •111, (½)., Ald,11 ttr. t.'ih,m,xl
`
`•~:; ·• .. (:11: lr H;-1>,)I•
`
`1•l:····Clty'(.11, l,,':h,
`
`(Y,) -O·Ot;tncl(H:Ull·l•OI ('!4!1,?.lJ .. ~l CrnH:,iJ) (~(;l;\.rl8); 11 mixllll'i) or
`1.1111H1l.1.m1t.otl 1111<) 1•01,111·11tr.cl hi1:h-mol(lcul111•--wnii;ht fuU_v nkohol~
`,xmKiK~illj( chit!n)• or ol!!,yl 111,,ohol.
`1' f llll411'fl llon ...... ()no mlll-h,1d t'Olld\l ¢1.hy) <'11¢111/1 with ,1h11ulul11
`llt,h,11101 n111I nlolulllc:nodium (Ot 1t .'iy11 C<11/ Ill: 1'1'/;\1 l!IM}.
`U1w,,1·IJ)tl1111 ... Clr,nr. 1:ul,11'h•1111 hi ll1:h1. y,,11,M, 11i)~• lit11.1i<I; foin l, ,,h,1M,:-
`1m·iH1,i<, 111l01· 1111<I hlr111d 11111(1!; i11!1111~ v11hlll hc11.wi:1:11 i;IJj nod fJO; hy1lr11x:,I
`w,h,e h,11w,!r,n ~,or, 111111?, Iii.
`1ir,h1billty .. :j,1h1hl,1 in ,1lt:ol1t>I, <>1111,r, l•oJ,t<>P)ti !ll(:.,hol m· liuh L 111i11••
`<,1·nl oil: in1>•>h1bl,, ill wc,101·.
`Un,:11 .. A 1>l111r11uw1mt.i11 uitl (mmtl11i(v i111: 111,<ont or ()n\<>llion t.) .
`
`Polyvlnyl Alcohol
`
`l•:1.111: tml, h11llhlJ.lllly111,,1•
`"[':l'lf,~""(jfl .. J-
`
`(.t;J
`
`,.
`
`Vi1wl 11l,:,ihol 1mlyt1H•1· [H00:~ .. 1;1t1-f1[ (C,~H10),,.
`1•1•u1,111·1,ti<H1 •.•.l\lb•vi11,vl nt'.ti\111,, i1• ,1p111·oximn\11l;v 1111% h~•1h·o(cid:173)
`lyi~•d in II m11l.l11111ol,11wlhyl "wf.nl<l 11,,!11tio11 tmin1: i,11.11<,r miiw1·ul
`11drl m· nllrnll 1111 rl \'.f1t11l.1•,.11.,
`l>OKIJl'h11luu .... ,\Vl,i(t! t,, ,,.,,,,llll ' l!ol11l'l!tl p,,w,li,r or' 1c1·,.,1111h•~: 1><l,1fl(i,1)1.
`
`J>l·IAllMAGl:tJTICAI. Nl;C(iS(ll'fllrn
`
`1io1
`
`l'.lvh1bl111y ... -F1·,•l'.ly 1111l11ht,, in w11H•r; Hol11(i,m 1,t'fo.-lNI 1t1<m, rnpidly 11(.
`;11 rnwwhnl. dl1v11 I ud Ct~mp,,rut.\Jl'tlth
`
`llN,!H·····A .~11~p1! tl(li1111 cr11,•11/. ,tnd i,m11/$iffr,r, "i\,hc\l' wlt.h i,r wit-h.-.ut
`l.hci 11irl ofu Hllrl'1wl 11nt. II commonly i11 mupl(lycd Iii! 11 h1hri,:irn11111cl
`prnl.<•tltmt l11 vu1·i,11111 opht.h11lmi1\ 1,ro11111•n1,i,•,i111, ~11d1 flij 1(1!con1111K•
`11111(.K, " "~ifi<.:1<11 fo1A1·1• 1111d <,m11111it.-h11w 1)1·c,du,,1,, <•c1, 1>111\11 IMl:I).
`
`Povldono
`
`· ,;.11c1•,.:
`,
`~ •·" N~,. ~;J) ;
`
`i ·
`
`1 L,.J
`i ..
`I• Vi1iy),:/,, py1'f'Olidh1011t 1)111.Vllllil' [(IOO:J .. :.lfH:ll iC,Jl,,NO).,; 11 11yn (cid:173)
`th,•t.it: 1111ly111<:r i'.011HiHtin1: of' li1w11r l -vinyl- ~-pyrrn li1li11111l1'. 1ir<1111111,
`Uu, d1!1p·~•• ofp11l,1•111v1·i½11l.i1111 of which rnN1illK in \lO l,vmo1·11 ,.if vnrio111.,
`m11lm,ul11r w11i1:htK. I I. i~ p 1·r1r.lt1(~1\l ,,omrn<:J·c:h1lly 1111111101·i1,11 of p1·,HI •
`11da h11vi1,1.( 1111:1111 Jll•>l,>t11lllt' w,1i1(hl" 1·,rnf(i11i; fr,1m 111),1111. 10,0UO lo
`'l'lw vill('.ONiLy or NCll11l.io1111 c,·,n1.11i11illl) I.0'Yr, i)t' h•~~ i,
`:1h(1\ll, 701),0()0,
`o~-.1111i11lly I.ho lllllllP lltl lhnl or \V1)to1·: aoh1l.icu l• 111111'(, ~llll\'.\?111,l'llt.('!I
`1.11ml llVY., b<1comc, muro vi11(,ll\l,, ch,pt:L1di111.: llf)Oll (.h(! ~onco11t.r11t.i1111
`011<1 I.ht• rn,11t11iul1u· wd1cht.,;ftlw pob•11,c,,• 1rnml.
`ll. 1'.m1t41i11~ I?. I•> 1:.1%
`Ill' 11i\r(ll!l<ll,
`f>r.ci1,,'1r11 tio11 .... , 1,,1 .. l'\11t.nnmllol l:1 clt:h,11dro1(<\Hill.e1l 1.h1i1•111r1lly wi1.h
`1.lw 11id <>f Mlll'>cr lo 'J' ••h11ty,, 1lu,,1.rn10, whid1 iii 1.h1,11 n•11dt•d ,vil h
`Ollllllllllin t.o fnrn1 :>.-)lyt·r,)licli11011,i.
`/\drlit,ion of ll1t1 l.1UO!r 111111:c•l.y•
`l(,IW y iddH ,•in)·l11,v1·1~11itli11011(i (monoilrnr) whi i:h l• pvl)lrn11riic1I
`1l1<!1·11111ll~· lu I.Ill' pre•1, 1u:c, of hydro,,,11, p(,roxidu utHI 111111111>11i11,
`l>t.,mi•••s,Ut1n ···•\Vhih~ lu 1~r.,,11uy whih•. tHi<nit~~li ;u•wtlor, h.\'1\tn1;c:,,p)t?;
`pM (I in :m 1.11,11,1 i,:11·,J :11.11 '/.
`S11h1l)III I)'· -S,,lnhln in wnrnr. 11 kuhol "r "hli11·nfon11; i11sul11hlc, in
`, 11ht\r ,
`
`liHIIH • .... I\ clix1,,,r~i111t ,rnd ~u~p,mdi,11: 111w,,1. i11 ph,11·m(11'.(,11tk,1 I
`11tvt>nrnt.iu11:;,
`
`Prn1,ylono Glycol Mo11osloarnlo
`
`(kt,1d(:t~«11\t•i1: ,1dd. monfW!"1,~r with I .!~,pt,,J,,uw1liul
`.1 ,2-P1·11p1.11u,tl1•1I 1,ion, ,111.,:/lrtll(> I l,;l;!:}.:)O,.:IJ; ,, mietur,) ,.,f t he 1)1'<) .
`pyl,111(, t(lycol 1110110 .. ,111•! ,·li1\11l<1rri ,11' x1.m1ric ond pnl111i1.i,, add:,. It
`1)()111.(linti 11 0(. luKH Uum !JO% of 1llol1111M1•rx M xn1.ura1.t!d f'n\l.y ni:1<111,
`r.hi«fly p 1'01WIM111 1:lyc:ol 11\01lo~1.cm1·111.<, 11:'.111 I 1'.1lh) 1111<1 propyl.,11,,
`11lyt'.<~I mmuipnhui tuu, (C111M:'"O"l.
`l'ro1111r11l.ion ..... H~• 1•,111r.1.i1111 1>r,111ylmm 1;ly(·ol wilh HI 1.mt·oyl d1 lo(cid:173)
`l'i1fo in r, H11it.11hl<! duhyclrndclnrinal.i1111 ••ll\'i1·,111m(,11t.
`l>11H111·i11ll1111-.... Whi< (:, w1,~•1ikt• 1.<,li<I or whit1>, wnx, lil11• 111:,11111 11r
`llnkt•K; 11li1cl11., 111ern1>nhlc, frtU,)' odor 111111 t,111h•: 1:m11;1:nl% 1101 lowc:r 1111111
`•If,•' ; 1idd v1.1ll1(, 1101 111111·1, 1.lm11 :!; unponiikutiva "llln,• I t,r, hl Ji\!.: hy1lr1.1xyl
`vn)u(• 1:)0 l.1\ J?O: jc,din•~ \'Ith" ~ 11uf mrn•1., 1h1m :t
`8ol11hilll.y . J)iHHlllv1;n i11 011,:1111k :;olv1111I• m td, ,,. ,1l,:11h1\I, mithlr<1I ur
`l'i~1\1I 11ik1, h(:IIY,Qll,:, ,,th,,r 111· c1(•.1,lc,11i,; inKulubt,, in w11ii•r hm 11111y lw
`rliKl>r!rkc,d in h,H wulvr with llw uid 11(' 11 111111111 ,1111011111 of 1111c111 or 1i1l1<"'
`t1hi1~·,t ,i(~ !)Ul'fm'n, ndiv,: Hf,(t'UI..
`
`ll i~ 11111•\.iculnrl)• 111ml'ul ,,~ u dis1wr11i1111
`UfftUl·· · ... A ~111'(,11:1.,1111..
`1\/(r.tll. for p<1rf\1mi, oilo or 1)il-Mnluhlc, 11il11111irn, in w111t1r, 1111tl in m:,,
`111c,tic 111·u1111n1l,i011ij.
`
`Slllcon Dlo>Clde, Colloldal••"'pa(,Je 1326.
`
`Sodium La,u-yl Sulfoto
`
`S11lf11ri1'. m:id m,m,ulocl~,:~·l ,1Hlr;r 1w.11l h111111111!.; li'ium; Doprmvl C
`(/)111x111/.); <'.11rdil1nl WA (l>n,ct,11· ,\,\ {h,111/1/,:J
`$odium mm1ork,<lu1:_yl n,1lftl1.<, [1 51-?.l •:l); 11 mM.m(, ol' ~odi11m
`1111<,vl m1lf1111:s tonRi11t.lnl( 1:hi<10,v of1111dh11n lmny) 11\Mnlu.
`'J'h(, c(>lll·
`hi11<>II ccmtc111t. of 11odilm1 (:hlr1rid1.• mlrl Hmlium N11lful.11 i» 11,;L 11111r1:
`l.lu111ll%.
`l'1·e1uu·11ii1>n .. , .. 'l'h111'1\U,y nr.irlij 11fC(ICl)llHl,,>il, c,111HiMt11111 chiciflyof
`lnuric 11dd, 1\1'1) 1:nh1l_v~iwlly hydro11111111t1•(I 1.o fortll tlw wri·o~pond,
`'l'hc: l11Uor 11r<• l-h1111 OHU,rll'fod with m1l!\irie 11d d <•111-
`in1111l~ohol~.
`roi,,d) 1111,I tho 1·c~11ltin(! mix(-11r11 11f 11lkyl hiH1111\1l~~ (nlk.1•l~t11f111·i•:
`ucich,) i~ ,,011v111·tA1d i11tu n mixtun'. of Kmlim11 ,11111.,., 1/y rc11,'.lilll: wi1-l1
`11H1o!i \11\dCJI' r.onlrollc>il ci11111fitio11(1 tlf pH.
`
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`FRESENIUS EXHIBIT 1013
`Page 241 of 408
`
`

`

`1300
`
`CMAPl'lm 00
`
`l)uNt•rh1tlu.11••·•:'.lt11111l, whlw or lhcht. yr.ll11w ,~ryHh1l11 h11vi111t 11 ~li~hl ,
`d111r,wh~rikli(0 ,utor.
`8olul1llltY•··· I Kin JU ml. w uhH\ l,1nui111t 1111 (>p11l1•~<:lllll. 1111h11lu11.
`l11r.<111111ulli>llil.io••····H•:11d11 wleh ,,111i1mfr .v11r/m•1:,m•(itw ''II"'''" 1,it.h
`hh\~ of l\(~uv•ty. tivc,n )n l!iilU:onl r11Uoth~ lfH) 1dW to {~U\rnt• ,>n•ci1>it0Uuu,
`lJnlik,1• ~•m1111, It in ,:,1mp11l.i11l11 wi1.h dil,1(1., 11,:Mn, 111ul 1!t1ld11m Alli m111:111••
`HHlm ll)lm,
`
`llN11H-···•t\n emul•i(vint:, ,1«,u:1·1cont.1111d w1:u.in1: 11111.111l i11 ointment,-,
`IAl•i~h powdot,1 nnd Mht,r 1►ht1rt11A1:011t.ic11I prnp11rul.i1.►1lK, 111111 in UH,
`nwl1\l, p111,l,r m1d 11i11u11mt. i11d11Hl.rili11, 8 1.:t C l1111>1.,r,i I fl ,111d /j'/,
`
`Sorbltan Eelorn
`
`S11rhit1111 ttaf,<11·~ (r,w1wlow·M.1! IJ:J311,,1H,il; mm1110/cml1: 11a:l~-4:l•
`ill; 111011111111/mitnte li(i206,67-0I; rtwm,Nlm,mu, I l3:l~-41 -6J; ti•iri•
`lr.o/.11 1~11206-58·0); ll'iN!v(//'(llt• l?-tl(lf,~-li),!i]).
`l'rcip1m1tlo11••···$<,rbil~•l h• d ¢hy,:lro~d lo form n l1«xit1111 whir.h ie
`Lho11 ll~lurifltd wit.h 1J,~ <hl~ltad fnt.ty 11<\Jd. $(10 Pol_yH11rb11l.!!A, pn110
`J.:JH, whfoh 11r(1 p1)ly1,1.hyhJ11(1 r,Jy,:111 1JlhorH of nnrbilnn fnt.t,y 11ci<I
`<'AL<trff.
`Dt,#erh1Uon••··• Mm111/1111m/,•: Amlu1t, oily ll1111id; mny lil'l~""" h111.y ur
`l'orm 11 ,)f(,r.i}1it.11t.c,; vinrnxil.y nh<mf.4,.li1l 1:1►(•; 1-11.H 110 ll.11;1,<'ill no '/,0 mux;
`enponifi(•11 tfo1i 111, {Ml u, 1'10: hydroxyl 1111 a:m lo :IMI. A11,m111/,•c11.1•;
`Amh~r liquid; ,,;,..-.,it.y "t,oul HlOO q,11; IU,li 1111 ,1.:l; 11..-id .,,, 3,0 nu1x;
`n1rp1111ifi1•1>1io11110 Hf1 lo I()(); hyl1ruK:,,I IHt Hl:I (o ?.IC\, M111wp11lmitr11,;:
`' I'm ,, «r11r,nl11r w,tN>" Holill; HI.II 1111 II.'/; n.:id 110 4 lo 'T.f,: H111>111\ilk111i1111 no
`140 lo l!1(); 1,y<lrt>X)'I n,; ?.'Iii to aor,. Mr1111>$l<•1u·11fo: Cre,11111 ht 111n h~ncls;
`BI ,ll 110 4.'/; meld 1111 r, to ICl; •••111111ifi,:ntio11110 l •l'I 1.v lri'I; hyclr11~yl 1111 2:1!1
`10 :!f«I. Trie,/1•r1111: A111l111r, oll:,, li,iulel; vi11t,11,i1y uh•nll ?.00 ~pn; l'I l,H no
`I.II: 1,,~ld nu lli m11~: KA1>011iri1>1.1lillll ,,., I'/() 11, l!lU: hy1lrnxyl 1111 M> c,1 '/11,
`'l't'i~l1•111'<1I~: '1'1111, WA~Y h~otlH; Ml ,ll no 'l..J; r•dd 110 I 2 1<1 H,: ,11111.-,11ifi,,n,
`lion 110 l'/t; 10 HUI; h)•elrnxyl 110 11r, to l\CI,
`Soh1hlllty•,.,.•Mo110/tmf(el"; $(1\11111<> 111 111<1tht1nl)I ,>f nkohnl: ,li11tmrs•
`ihl1, In di11tilfo<I wnw· 1111<1 hnrcl wute,· OIOO 1111ml; i11;111h1bl~ in hem1 w11ter
`(?,(l,OO<I IIJlill), Mo11,1,:,/~11t1•: Solubfo 11111111~1. 111i1wr1el or v~J(olnbl<' 1)1111;
`1<1i~hlly s11l11hl 1> in .,1(1,,r; di~ll<ll'l11hl,, in w11tor; i111ml11bl(, 111 1,,:01.1>111,. Mv11 •
`[)i•1>orwll>lt• (r,c1•) in di~1.ille,tl w11111r or hurd 1v11t.oe· (200
`111>11lmilc,/1t:
`ppm); k11luhl(I in ,,1.h:,,I ,u:~l11Jt1; i11~•1h1hle In wl,I <1io1illNI wnl"r vr hurd
`!:>vluhh, (11hov11 m~l1.i1111 point.) In
`wnl~r (?,{),()1)0 1>1>m). Mm111~(1?11r111<':
`vo~l•lulth, ult~ ,,r mltwrul oil; i11Hnl11hlL• i,i w11tur, 11li:11h,1l 1.111,I pmpylt11w
`'l'ri'ol,u,t<•: S1,h11ll<: In miuornl nil, v1•Jtul11blu oll•, nl c,ih,,I ,1r
`nly1,11I.
`,,u~(hfllUJI: humluhil' in wut(\t.
`1/'l'tt.·tt!UIV(((•: Hn111hh, 111 h1cn,rnprl 11t,ir),
`h11I: il,,µ,lublc, iii w11t,!i-.
`ll11<•H•··,Nonionic R"1'fnt.'/.c111/ .. r tlrl\ld 1111 ,1mr1/.~ifyi111/ 1111e11/.~ i11 i.h(l
`111•i,1111r11lion of W(1(er •i11-oil omul~ion~.
`
`St<rnrlc .Acid- page 13 12.
`
`Stearyl Alcohol
`
`l•(k\,u\11r.1111ol ll li!,(l;!.:.11 C1~l·l:1i) (?,'/0,C,O); <amh,111~ 11(>11(,>< Ll11111 !lU'JI,
`ol' ~10111·yl nl1:oh1•I, 1110 r1111rni111for ,1.,11~ir1tin11 r.hiefly of tMYl 11k(1he1I
`1c,.1~,,,o 0 ~42.441.
`l 1rormr1\thm·•-'l'hrou~h tho 1·ocllwh11111ctfon oflit.hium 11h1111h11m1
`l1ydri<le) 011 uthyl O((IRrt!\(1.
`llok~H or 1cr111111loP h1ivh1u ,1 roinl,
`l>~ff~~l111l1111 ... ,.WJiito. 11111:t,uo11t1
`d111rud11r!nt.ic 1><lllf n111l 111)1(11\d ({lk\h; 111(Jllri Mi '" Ii()".
`l:loh1bllli:t1•···••l11,1,1luhle In Wlllol'; •nh1lM in 11\cohol. chloroform, <)1hnr
`11r VOf(lll nhl11 ,,ii~.
`uijj}Q••····" uurfll('.Ct •ll~livo lltJOllt 11110d I\) ,1(1/ii/ii,1 rwllllRitlllR und
`h1crot111<1 tlwir nhility t~, rotnin l111·11u <1111111~ll.lcnofw11t.11r. SouNydr'I)•
`1,hilid)i111,1w11 (pago I :fl 2). Jl)•tlrnf)l1ilic f'1!fm/11t(111r (1111KII I :ill),
`ond Ch,,11ui1\1 HI 1111d f.17.
`
`8teroull11 Oum•··-POOG 700.
`
`Traoaonnlh
`(:,,11, 1t•nmncmn l,; Mn,c c;un,: {:w1t'11 Thorn
`. 'l'he clrlod H111111.ny_vx11d11~i,)I) from A~/.rugt</11~ ll""1111ifre1• l,nhill,11'•
`d ,e~(!, ()t 01.111,t 1\11,nhc Hll?.<'.I~~ of A~li'(I/IIIIIIN (!•'nm. l'.11,-11ml111W1<,!),
`( ,oll•tlt11011IN·····;~O hJ 101,. ,h11~~0,iu 1111d ;10 111 •11)% ,,,,luhh1 i:11m
`) he b1lHHm·111 ,1wc,HH i11 l•h<• 1m,11(!t1cc of wot()1' to
`(1.ron111:11/ll/1111).
`forn1. 11 l{OI OIICl l.rn,i111:11nt.hin f.ot11111 ,1 "olloidnl 1101111.imt B,l~l!<)rin,
`()l)lll\l•t.11111 of ,:omJ)IOJ\ llHll:hoxrlllled 11<:id,1, tl?H<tmhlt!ll l)<ldin. 'l're, ,
`110f.AIJ1,hh1 yrnldH gh1cu1•1n11,, 0,11111111d nrc1binu•11 wh~n hy<lrol;vii11l.
`D'.>11tlrl11tlt(H····· l•'l111:h<t\(\CL llmu,lldh•d. f1rn1muilly ,attl'tlll frAfllllClll• ,ir
`~ln11Mhl.11r 1111,tr•.ll:,, l,w1•tr.d lmmlr ple,:(111 O.f, ,., :U, mm 111 t hit.kur:••: whih•
`1o w~tnk~yoUow m colo~; tr,11H1luc:unt; h,_,,o~· h, tt~)I.C,OJ't!: mlotJu,,,4~ h\tilpid,
`\\ hem 1iow1lored, 11, i, whih} 1,1 wllowiuh whltt\,
`m11nh1,i11w11K l11Hfll,
`• h~t.1·,whu:,,i,l l1l(o 11'1.1l«r.1.rnr111r.11nt.h ,,l)lr(ti'hK" 1:torl11in 11roporci,111 ,,r 1l111i
`1111111<1, 111,·1•1!• vi•ry 111\ll:!1, ttlld fu)'lm\ n, ij1)1'(. udh1111iw p,,.1,,, t.111. ,1(,(,i:, 11,>t
`1lihH1llv11. It '!U1t11t.,,d 1~1!11 11\l l•~i:11••1111 w,1hn, lhiH 11111111, form~ 11 uolfonn
`mlwt.11.rn; hnt rn 1.t .. , ,,m11·11,1 .ot I o.r :I. <lny,, 1h11 ttt1•n(m· pnr1 "''f'ill'IIIOK, mid i)I
`dc1x11S11.,,,1, .1i11w1~1~ n 11'.1H1,11~ tl1a.,1lv~d m th(, ,;11p11rnn1,mL nuict. TJw
`fi11u11C. """"'''"'' '- nl►(n11l1!d lrom u?'' Wlh)li,,K \1111 llr /(11/,,• form. :;;,,v111·,1I
`1!11y• 11houlcl ho 1,llull'{1d lor oht,-(111111111 u111r.n•m 1111wilnic1i 11f 11,., •►•tixl•
`m11m 1101 ntr1m111h. A ccm1111m1 nch,lt,ir,mt. i• 1(111',cl'tl (! 11111
`,,ml 11,,.
`1.181'/NI" hu•.11111,1•ud111:1:tl tm,f,o t,; rlN~('.( ils 1"'';~1111<~1,. '
`'
`·
`8ul11bllll~' ··'•l11011h1hltr ill nlwh,11,
`
`lJK111S•··••II ~11N/)1!11di11J1111/"111 ,n lot.ion•, mix1.111·e,i 1111,I 1•x1<1t11JH•<n-
`11111111~ l)l'(lj)\ll'll(.innH 1111cl t>l'l'HCl0ipt i011K, It'" IIKNI wit h tlll\11h1i(\'in1:
`r, j,.
`11111ml" l11r,wly to 1,11:1'"''"" <'.•ill1•1~1m1cy 1111d rctord <:1·.,~ml111<,
`1,omc~imo unml m, 11 1/c.,11111/1:1111/ 111 Morn thro11t., ,md tlm jl,11:,t,lik"
`11rnch1d. r11rn11:d wlu,11 1.11,11i11m i~ ,1ll11wt1d 1,111wcll i11 wnh,r 111.,r,•1,~ 11~ 11
`bMi~ f1.w oh,1rmocou1.i1:nl j1!llioH, 0111 /o.'tJlwdri,w Slli/u1,, .J,,1/y,
`11.
`nlHo IH 1111<,el in v11rim111 1:onl'11f.1.ioncry p1·mh11:tk. In \h11 fot1n ,,r u
`1tlyc1,rit1,, ll h~fi hr.<m UijNI nH 11 ,.,ill 1.•xd1>i1,11t,
`, '1'rn"l1(,u11th M1wil111i,1 ••••.f'Nt/>llmti;,,1: Mix 1:h'~1Jri11 t l ~,:) wieh p111'i•
`(uni wnt\11' ('/f, ml,) i,111 lurticl v1,-11(1I. h,;n(. the, mi~c.un, lo hoil i1111. ,li~r:nn •
`111111a II« n1>11lic:111lon ut' llltnl, ur.l\'.I I.J'J11l>•l:1111th (Ci,:> ,11111 h(1111.,,1t: ru:i/1 (0.?.
`I() 111111111,11:Nt,t•, 1hr. miKC11rn ch11·l11r. :14 hr, 111irfin11111;1'r\1;lnn11lly.
`·1•1,~.,
`,,,M 11111hli;h 1111rilitld w11cm· h i 11ml11; lh,, ml~hm• wc•itch 10011, ~cir 11,·1 h·,,ly
`1111\.il or 1111iform c1111nl•h111,:Y, 1111<111lroi11 r,,,.dhly throu~h mu,,Hn.
`/!,,•~:
`A fllU~pc,ndlnsc m;<mt for inn••luhlc: .. ~il)nh, ,h~1·;t\ ii~ inturnnJ n,ixtur,m, I( i~
`(111'() ,, f)l'bl ('("/ ;,1,.• OJ~•~nc.
`
`l(,,lir.,I Ui~lt•<>l
`
`f', hi11h•mvloc1il11r•wd11ht. poly111rnd1aritl1· r,1m1 p,•ml11,,i1d hy 11
`pm1•-ct1IL11r11 forme111!J1Uun of 11 corhohyd1·111,, wic.h Xn11tlwn1011t1~
`,:omp,•~tri~, 1.h1111 p11ril'ic,cl hy roc:m·11Q' with im,11(of1~I ,1k1•h11I, dric1I
`1111d 111illocl; c:ont11i1111 l).1(101;11~11 111111 1>-1111111110111l l)M c.h1! 1lomi11,111t
`lwx,Ku, 1111ll~. 111111111 wit,h 1 ► ·1;J11cur1111 ic lll!icl, 111111 in 1m,pr11·td ,,~ ~11111·
`um, polnMKinm or m1lcii11m 11111!,; yitll,h, ,l ,?, 1,1 ft% of 1:11rho11 dioxld1,.
`J>.-ol)ll\'11tloi. •··•Sr,1J 11hov111\iltl US Pull; :1,4:1:l,'/Oll 1111d a,:111•1,011;,
`Uc,1,irl))ll11u•••·Whih i llr ,,rNllll··COlorNI, 1111•h>l1•1111 ))IIIV<I~, wiU1 (1 !tlird11.
`OJ'(tnni,~ od,,ri ,,nw,,tJr 11ud )\uhHl,)H" 1\lrlhlc, nc 2H" ,,a· l,!~tt; dtH~K not oxhlhU
`1wl:,.•n1<,rphi1,m; 1u1uco,h~ nuhtt ioJ)n m'(' u,!utr,11 lo litrn\lK.
`~,1luhlllty• .... I 1: i11 ul,11111.:, ml. ,,f nle'<lhol; Mol11ltl11111 h11t ur ,,,,hi wnw,.
`Ut111N•····A h:vdrnt>hilic mlloicl t,1 1hi1:k1m, ,111111>mul, 1111111l~ify 11ntl
`11111bill~1! "'nl.or• h,u1cd ~ye11mn,.
`'
`
`()l.hr.r l•:mulNl!'yluU 1111<1 8 11H1111111fin1C t\l(,:11t.11
`C J1undru11 IJri~h Mm,~: Ci1rM~111!111111l •·· 'l'ho 1lri11d 111111.IJl\,r111h,,d t>lmll
`111' (.'})e,1t<lr1<s f"i·•/m,v (J.h111M St111:~h1r11. 1, (t,'1101 IN,i111·1 i1w1·,·111•),
`I /~1•,:
`l'rindp11ll,v, ."~ 110 u111ul11if>·i1111 n111•1H 1,,,. li•111id pr.11·0111111111 111111 l'or n 11I
`I Iver 011.
`IC, 1t1 ,,l,11, 11 111·,11~,:t1ve.
`Moh ••··-'I'hu p11rli11lly 11111·mh11111,d ;1rnin of ,,,1~ vi 1n111'l' ,•111·i<11ir.~ u(
`Jlortlc 1Hm 0111,:m·•· l1innt; n•·J,m <ir1tmrn•~'h') outl ('.oulniu,, mn,•lol\'t,ic l,d-•
`\/.yintrn, Yullnwh•h e,r un,bt:l'·•c..•olnrml 1ctulrm. hn\·int: 11 d1m·Hd~idwik 1Hl,,.1·
`nntl n »wt~1,1. trat11t,.
`'l1h,, evuJ)urnJr,,I ~Htll\l•Hb~ (~~l.t'nd ('.1)ih1tiluuo1 mull
`1,x1.rn,:1.
`Mnll 1,:~, rnot•,.··'l'lw pr1)th,1r1. ohloin~<I h:, e:xt1'11d.iil111111111, th~ p,1rt.it1I•
`ly ,11ul ,irllCll'lolly l\(ll'i\liH(ll,NI f(rllill 11r 11111! or 11\01~• vnriC1li1>~ of ll,w,lt-11111
`/\11 infr,,c1ucn1tly " "''"' ,~nni111'·
`1:1,IJl,it••; tJim~(t ( l1'J\01 liNm,fo,fth!}.
`l ltJl'H:
`l'yh11111111•nl.
`.
`
`FRESENIUS EXHIBIT 1013
`Page 242 of 408
`
`

`

`I I I I I' r· I . :r:1111
`
`. I I
`
`...... TH ii" T "
`
`. ·;I .
`
`l'I IAl~MA(,l.;lffrCAI. NECf:SSIY!liS
`
`1900
`
`Ointment Bases
`O i11t.111e1111J1 ,11·ti /.lt!ll1Ulolfrl prrpn1·11Li011H f'ur c11t.ur1111I ,ippli,
`which pci:.~uH,:t~ r,ll l,h<:~c: chm·acLcl'bLit:~. mnt i,111,id 1'\ltll1t1'd1
`in !.hi r. lfold h11i. 1·0111 111,c,d in l.lw d<!VC:lopmcmt of' nu1111•rn1 1H
`<=nl,ion l.o tlw ll<)cly. 'J'lw,v llhould bt! of:urd1 t">lllJlnxir.hrn i.haL
`l,li(iy 1<1.11'(.(,11, 1ml. not lltl<;c~~urily mtiH., wh(!n npp]i c,rl \,o 1.h,,
`11uw h11>1011. J ndncd, oint,l\l1llll. hM<lll h(W<• bu<:onw ~1.1 1rnmc,1•,.
`'l'h1!rnpm1lfo11lly, oil\1.111.:,n1.~ f'um:l.icJn n11 IJJ'o l.1:div<i:1
`111.m ml I.O l'(lljl,>ir(~ IJl}.iRisifient.ion. Alt.l1ou1-ih ni11 tn11in1. bMll~
`s kin .
`011 11 omollimrw for t,hQ xld11, h11l ,iro 11t1~d primurlly 11:1 vchi (cid:173)
`moy ),c, 1:mupocl in :;1:11<'1'11! wn:v~. ii. i"- l(mlcu'ally 111(rMtl I.hut
`t.lwy c:1111 hi!
`d c11 or h11:icis for U1c: t.opi1·11I npplic,1li1111 of' 11\IJ<lidnol ::uh•
`,:l111111ilfod l)(ls\ n(:(:<Jrd i111i t.n c:olllpoail ion.
`1-lc:nc.e, l.lrn followit1H fou1· dn~~n11111·,t 1·c?c:og11i~.nd lwrc? i11: olc,-
`l!l.:111e:ol\. Oi11(,11uJ11t.11 1.11110 muy h (i appli11d t.11 1.Jw cyci or t:yu •
`lidt1.
`111: h\ous , u1m1h;ifi11hlo, 111n11lsio11 111111111., 1111d Wfltc:,• .. sol11hl1.' ,
`ldc,:rlly, 1111 ni11l.11Hm1. h1t11(, Hhl/~lld bo 1;01np11t,ihl.11 wit.h l,hc
`· F'or t:rn11plc~t!IIO>!i,, s 11b~l1HH'.n11 lll'U in1:hu lotl I.hat, all.h ou1d1
`1ik i11, fif.nhle, 1,uri111,11c11i, llmool.h um.I pli11l,lc, 11()nirrit,nit1ft,
`not ,mud 11101111 "" <1i11Lmo11t h11:-1is1 <~in Lribu101Jomu ph a1·ma
`,~1)\ll.ic:111 prnp<!rl.y IA> on e or moni of 1hc v:1rio11~ hn~t•/1,
`11111111N111if.l~i11g, iH(l1't 1111d rc11<1ily 11hlt- l o rtlft:111w il11 i1worJ)(l•
`rul.<id 111c:dic,11,in11. Si11c<1 them i:, no 11111,.rh! o i11t.11rn111. b1111<!
`
`Olt:6'glnous Ointment B11st1s and Components
`
`''l'ho ,,IM1~ino1w oint.nHml. h1Hm11 il1dudo rixed oihi of v1~1:<1••
`l~thlo 111·i1(in, f'nl~ ohl~1iuc-:d frmn 11nini11lx 1111<1 81!11\limlid hy•
`drocnrl,111111 obt.nhwd from IH'Lrol1m 1n. T he, v1~(C!l41hlc: Pil:,
`aru \lij(1d ch iBt1.v in oint.nwnlh Lo low~r U1c• 11wlf.in1< poi 111, or lo
`sol't.un l>H>l(nl,
`' 1')1111;0 o il:1 <.111 11 lw lmud 1\H II hmw in tlwrn~dv,.,:~
`whM i.1 high l)(H'crmtr1nc! of powdo,• ii; lt11:M1·ior111.1~d .
`'l'lw 11qt<:toble nib irncl thr. 1111imnl r,1t11 h,w1, l.\v<1 m11rk1~cl
`th11ir wnt,cr ,,11;.~orhiii(! Cfl •
`<liR111lv11nt11i:ox 1111 ui11tmc:11t h11.sti~:
`p,u:ity i~ low ml<I t ht\Y hnw 11 1-tmrlcmr.y to b11,:c,mr. rnn('icl.
`I n:mfor w, ''t!l{(1tc1h lo oilr1111·1, c:t111i:c1·,wtl, WH: :11:cmHI di~adv;(l1 •
`t.11110 cno bo ,wmw,nw hy hyd1·011011nt.ion, !l pl'Pl!Ottll which
`mnvnrt.11 ,u,rny fixc,d oil~ inl.o whi to, 111mli8oli<l fhl.~ 111· i111.o
`hnrd, nl mnx~ ht'iLUn, w11xe11.
`Thu hydroc:nrbon hHt1<Ji; tiomprisc 11 f?l'O\lf' c,I' 1111h,;t1111<:l':1
`wll.l1 u widt! r11111t,ll M l\\(1lti11 1~ point·~ NO 1.1ml. 1111y d1111fr1Jd
`cmH;iijltHH:y 1111<1 mc:ll.11111 point. m11.v be: l)l'l'.p111•cd wit,h r<'r1r(I ..
`11<1nt11I iv11N n l' (.hi~ ~ mup.
`·1·1wy ,u-11 i1l11hln, liland, 1:ho111k11lly
`inert. und IVill mix wil,h virt111jllv onv c h(l111i(:1}f :;11hi.tnnc,1.
`Olcn11inow1 h11111m :u·e: t)X(:(i ))(H) \, C)l;ltlllionti;.
`
`White Olntmonl
`
`Oiu:.,11,,111 I J~I' XI; S l11111lc Oi111.1111•111
`
`IJO If
`Whitn WII): , , • •• •• , •• , , • , , , , •.. . , . • , , , , , • • , , . , .•. ,
`Whh \11'~irol11 111111 ,,,,, . . . .. .. .... . . . .. ....... , . .. Q50g
`'l'o n,11ko , , • , . , ... , , • , , • , , , . , , . , . . , , , , , , .• , .. . , .. l 000 i_:
`
`M:ilt. thu whtl11 w11x In 11 ,1Hit<11Jh, ,.(i11h ull 11 11•11\1!1· h11Jh, 111lol l,h., wh ih\
`~•<•tr11IM11111, w11r111 •111iil li,111,1fi,,1l, 1h~1\ di:•r1111(,i1lt1f: ih(, l1t,(11,in11. 11111l 11(ir
`1J11• ouixlor., unt il ii h1~:i1111 lo L~IIIN••lol.
`It ii, 1i11nl\f,iij jl,l1• tn V(lry 111<1
`ll•~l))(ll'li.)11,1(wnx 1,1 oh111i11 ii 11ui(11l1I\· ~'(111••~11·111:y 11( Iii,• oinlll\\111~ 1111, IM
`diffi,n,,,1 i:limiil k ,1,m11ili111111.
`
`YDIIOW Olnlrnont
`
`Yullow W,,x .... •. .... ... . ... . , •. .• . , .. . .. . . •.•. . .
`t1(1g
`1'11t1·ol111mn •. ,, .. , . • , . ... . . .. .•.. .
`. • , , . . . . , . . , , , • !J.~11 JC
`'l',1111111:c , •• , , , .••.. , , , • • , , , , . , •• , .... , , , • •• .• ... I 000 r:
`
`M<,11, J,h◊ y1;ll1,w w11x in 11 »11l111hlo lllah 1111 11 "\tmm lmt.h, nd<I th1,
`111·1roh,111111, wnrm 11111.II H'lur,fi~d, 1.hu•l ,li,,·,111lil1111) 1h11 lw1nin11, and 111 i1·
`1hr 111l•111r~ Oll(il ii IH•Jtin ~ lo ""•1:1,r.l.
`II Ii, t•·•111ii,,ibl11 l o vur),' lho•
`ll'Vlll•rl hlll 111' w,1x to) ,,l)tnin n ~uit11hlt1 ,·11n.-in111111·i· or ~h. ui11lmu,1l \llld N
`cllfh,-,.,;nt d imn(.ic: c,11111li1.f,·m,,.
`
`Cotyl F.ston. W.ix
`
`/I 111ix1.11ru c:,11,.•i~lillK winrnrily of c::swr.• or ~tt~orolr.d fnfl.v nlrn
`I(. h,1,.1 ,1
`h11h, (C.:1.1 Lu G1Ml 111111 1,nl.11rnlt•d fnl.t.,Y 11d1ii, (C 1 ◄ It\ C1x),
`~npooifi.,111,i1n1 v11lwt ol' I(!!) f<, I :m nnd 1111 11d1I rnl1111 nf 1101. nw1•c, 1.111111
`l•.
`l>u1;c:<i1J \lo11 Whil,, 1<1 ul( whil.u. 1,v111(•Whal c rn11,lu1, •nl (1 11k,•• : ,·r\'~·
`u1lh 111• w~m~l11ru 11ml Jl('llrll' hhll <'r wlwn, 11hod; ,.,in1 ,ulor nn,I 11 1,1,,;~1.
`mild 1,u, h•: .. ,.,,,, l'r,,111 r111wi,IH 11: ,;pm;1(i,: ,cril\'i\\' 0.111.0 lo 1>J-U() Il l, t,(l'';
`i11rli110vn'. 1111 1101111m'f., t.h,m I: ,'1whu •t: l 1.1, 4?''. •
`$11l11 hlll1y----•ln~ol11hl1• in "'"'"t; 11r11c:llrn1ll.v ;,,,.,.lt,h!., i,1 ,:oihl nh-,,111,I;
`m1lnhh• in h11ill111; 11loa1hu!, c,t.hllr, d1loro(11rm m· lh ,·d MI\I eolr11 ilu 11i16:
`:;fir.hfl.1• !111lo1hl1• iu 1"~11 nulv,,,11 hvXttllt'.
`I.I,,,,,,.·· -/I ''"i> 111,~c• 111011 t l'<lr :1p1,m101·.<,l,i ur.<,d Io 1<i ,·o 1.i1111i,11.1•11,:~· am'.
`1.<,~c.,u•<1 l,i,11.1l11 l,ntN11~, 1111, (.'u/rl C:1•1•111111111,l J(,),,,_, W111111· Oi11/t1r, •11I.
`
`Olelc Aolcl
`
`Olr.lc 11!:icl (t ll-!•!Jll-ll 11t11ni11c•tl from 1111Jow ~1111 ,11hc!r fnl,. . n11<J
`""""i,1l k d 1iutly of (½Hl -1idmln<:<-1111i1· 1wi1I (:!l.\?..-1./l, Olt'it: 11t:i1I 11~1•.'.
`in prn1,111•111.i1111,, ru,· inl.on111l ,1<1,11in it.i.r(1t ion i~ <1,11·i1•1,1I r,·11111 l\dihl~
`><Oll((.ch,
`h 11~011lly 1·1111tai11, ' 'lll'i11hlo ,11111111111~ of the 111,111•1' 1',111y 111,i,J~
`pror,1;111-in 1.i1IJ1J\Y ~th:h IIH li1K1l11ui1• nnd ulonrir 11r,1l11.
`Pro1>11r,1Liun-.. ,OhL111i11<cl II!; n hy-11rml 11ef. in tlw 111111ncrm:1u1·1: ur
`th•! MJlid 111.1,nri c· nnd fJ11'.mi1-k ncid:, llll\\d in Lho 11u1l\llf11ct.111·1• 111'
`'l'hl< ,,.·,11lc ulc: ic nc-i1'. i,,
`1:11111ll1!H, H\Cnl'ltl,(:$ nntl (11,lwr prn1h11•l11,
`lcn()wn 11~ "n:1t 11il," I he, Klc:nril!<111d 11ohni(.i,· m:i11t1 lmi u11 :11,pnr,H~cl Ii~•
`m1olir111,
`
`DoH111·h1l.i11 1l ··· •ColMlcH1, l\i 1n1 lt, yoll,1w, 11ily li,11.1id: lnrd -lilw mlur 11111(
`111111.,:,; •t,c,dlk 1mwil,y ll.llflil ,,, IJ,8!111: .,,1wu1li 11\ 11 t1:1111i1ir1,i,.1r1, 1>0t,nhi1l'i!
`I 11°; '""'' ru:1,1 11,1'.i1lif'it•~ 111, ,1•: oil ~1.11111,11l11irfo 1m•Hm11·1• ii. 1!t:1111111111•~~:•
`whon h,v,1"'1 nlflll lu HNI'':"" (IXJ\l):o\ll't• , .. 11ir ii 1:nulv1,ll.1• 11111. ,rh,1 oxr1:1•11,
`du r.h 11, nlltl clrv,•lopi, ,, rn1ll'id nolor,
`l'1•11r.1.imllv i111111lo1h11• in w,11,,,: 111i11dl1l11 wi1 h 111l'11h11I,
`S olubilhy
`1:,lol11nifm m, 1!1,h11r, h1111'l.tHi1• •1r t'iK1,d ,uui v.1)01il1• oilH,
`l1!1\1lll"U)111\1Jllhitl~ -" n"tt(II II wilh 11/11111/,.•11 h i form HO>ll)h,
`/frrw,1· /twl ·
`rtlN ,uirl m1li.','10H 1,11 /tt. form in1toluhlu olc:rtlPN, /wl,',u, 1wl11limi,; ,1r1~ dtwc)I,
`ori~ccl h.1' (orm111i1111 of llu- ov1ll111• c,ilil it •111 ,,,mpu11111I o( th" ,,..;,t, II i~
`\)X.itfi~A·d to vw•i1')\lft cl•~rl,1111 h•,u1 lay ,,,'tr/t 111'1•,1, f>h1t,.i11ll,n, /Jf'Jm<m1m1wl ,•
`1ol1l uH1u1• nw.1m,,.
`UH!\/l····CluHMir.iCd nK 1111 c,11111l~ii•11 11dj111w1., which 1·<•1u:t11 with 11'. lc,, ,
`li11 t,, fortn 11111111,1 l h11l f\tnclfon M; 1111111J:lif~•in1111nunl~; it. i• 11•1:d for
`\h~ p urp•nn' In K\ICh prc,p11rnl ion K BK lu:111yl IJ1•111111.1/1> ,~11lc111 nn,1
`1.,•r~1,,1 S,Nlf). h "'~" is 11111)11 lo l>l'(IJIU I'(' oh:nl C MIi ~ or l)IIKII•,
`
`lJij(l~ •J\11 C!lllt11'.i<1nl. M1cl voh idn for olh1:1· ,1i 11l m(111t,,. lloth whilu
`urn I yt1ll11w ui1111no11~ nro knm,•n 1111 "11,111p1t, •~Ill lll¢l1l." Whit<, o illl·
`11Hlll l 11hnnld IK, ll~l•d lo pt111»11·11 whii,,, ni11 t11im1l11 and )'(1fl11w oint(cid:173)
`mcn\ 11 ~hould hco 11~1id 10 IH'o1111rn c:ol11r11tl pi nl nwnf.:• wlwn 11impl c
`oi11l-u1t!ll l, i, llrflK1'<r1l1<1,I,
`
`Olivo OIi
`f;"~·••f 011
`'l'h<: fiJC<11I 11il ohtoinod l'i-11m 1J1<, rll)\1 lh 1h ,,r Oh•11 r 11rt1/JC1t•11 I ,i11no'•
`I 1•'11111 Olm11:1:111:).
`
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`FRESENIUS EXHIBIT 1013
`Page 243 of 408
`
`

`

`1310
`
`CM/11'1'1:H (10
`
`Pro1111r11ilo11, .... Hy ,,rn,,hinK mrnmtly Gollodoil ripll ollv<•• In II mill
`without bn\,1kinr; I.hr. putnlll(!ll, llw1111H>d(:rntoty J)>'CH~inl{ th<l 1>1.1lpy
`'J'hi~ J)f\'l<IUCCK th<• hi11h(t8I, tirmhl oil, know11 11~ vil'llill r)i./,
`01111110.
`"•11 hli1111,oil'' nr " firHl,mcproHHml nil." Th11 mu~n in 1110 lll'l?HH t.Jum iK
`mi~~<l with w111.\n' und u1c11h1 <•x11r1,K~(,d with grea (,(! r l)l'()fi~u fo, 1111 oil
`of ll<l('und <1n11li1 .• v r,,~11ltin11, Any ,,ii r11n111i,tin1; in tho J>l'C>k~ mlw it,
`finully (IMt,r(u!tml with cmhon d iH11lficln, or 1.h1• 1111111• i~ l,hMwn into
`1111·1:~- .;hi!.or11K, mbtti<I with wnu,r 1111d U1r. oil 11llowod (o 11011r1r11tc.
`'l'hiK iK HOlllCl.hll(I~ ,:nll(!<l "l'yrcnn oil," ''bngnHK<l oil" or"h11il1\ <1'1111 ..
`l'cr." Wlwn l,111,11:ht. in hulh or from tml11h1,J~d <:11nt11lncri;, coU,(m•
`1•\\(>d (>ii, cillz11 oil, g1•11pOk(:c,d oi l, :<Cr1n11w oil or 1lthor hl1111d oilH Mu llilt
`uncommonl:v f,1u11<l u11 ~,duh1,i•4111l.ij. I ,Hl'f{(\ <tl•nnt.it.i11~ of thiR oll 111·11
`hnportcd lrom ltAIY onll oUioi· r.01111U•i1•» h(11'd1>ring the, Ml\ditorrn•
`11(:tlll, nn<l if. iH 11rnd11<:ml l,o II limil,od oxu,111. in 1.1111 $011U11H·11 U:.,,
`chieny i11 C~llfoml(1.
`l).,~1:rl11t11111-- •-l'nh~ yellow or li1;h1. r.r1!1miPh yr.11,i,v, 111ly ll1111i◄I; Hli~hl.,
`uhnrn<:ll'riHlfo 11dnr 1111d c,1,1tt1, with ,1 foiu cl,v nr.ri!I 11ft..rt11HI<•; •Jll'"llk
`1,1•11vlty OillO LO O.!Hli.
`8ol11hilit~•• .. ·•Sli11IH,Jy ,1r1t11lllc1 in okolwt; miHr.ihlP. wi1.h 1:~rh,111 dio11l(cid:173)
`fi11<!, d1lornt'orn1 or l\lhrr.
`
`II.
`lJses-----ln mnkinl( c1m1t-11~, oinl-mo11l;i, li11i1llm\lu, 111111 p ln•l-1•1~,.
`i• 11 blnnll oil, w11II-H11it.f?tl for 1m1o//i,;;11. p111·1111ijc11 1\lld fm food .
`If.
`(Ilk<> i• lt•<>d (IB ,m oll\◄)llfonl h1xotJv(\; 1;ufficiolll- n111nf. h~ 1tivo11 HO thnt
`m1m11;h 1mcujl1m ,liJ{l:nf,i<)tl t.c.111111'1,,,n Liu> Hl,ool.
`Ooijo ... ,.'l'hc U('.UI\I dOij¢ iK 30 ml,.
`
`PnrAllln
`
`P,wnffi11 Wnx, linnl l't11'11W11
`A 11utifiud mixt.Ltrc or 1101id hydro~11rh111111 ohlninocl fr11m P"'tt'"·
`
`1011111 .
`l>~Hctl'i111lo11 C11lorl1•~~ 1,1· whito, morn 11r l1:11• l r11n,,h11:<11lt m11,.,, with ,1
`t:r.WlOllitHI 1)tr11r.tm11: kli1,htly ~ri:11~:,- lo t,llf• t.<111<:h; ,,(11,ri,,,, rmd IMl;:lrAn;
`,:,m;i,,olK >17 1,, tJ()".
`8ol11hlllty-, .. f•'rc111ly Kohthlc in d1lur11Cvt11, , dh~r. 1•,,l,1tilt1 oiln ,1,· tn•mf
`w11r111 fixl\(l l)fl,.,;,.,lir,htl)• ,ot111Jlu i11 dohydmt1:1l ,1lc\lll(II; in,nluhle in wntm·
`,11· ,,11:11)1111.
`
`Pot,olotum
`
`Ycll,,w Soft. 1'11rnffi11; 1\111111,r l'111,rnl11tum; YP.lluw Pnl-n•lnl,111•1:
`l'P.1,rnli,11111,)olty; IIA1·,1t'fh1 ,l<!lly
`/\ 11urifiod miKll trll ,,f ~(t1;1inolid hyd1·uc1ll'ho11~ obt"in<•d fr111ll [)~·
`Jr.11111,v 1~<mti1in (I ~11il.11hl<> 11l11hillr.(u'.
`trol~utt\.
`Prill►i1~,,1i,m, ... 'J'ho "t•N1ld11um,,:• 11111.hr.y 111·0 (crnwd t.cclmlcolly,
`whid11,r~ nl,h1i1111d by Uw 1liKl,ilh1tinn of fJ1•!lro)1111111, lll'O ))lll'ifiP.Ci by
`molting, u~unlly tronth111 wit.h >11111\n•lc n<:!d nnd \.hon pel';;nlntln,i
`tlm>1111h t'(!(:(u1Uy b1n'1111d Imm, hl11,:k 01• rotlKm·pl.iv~ d11.v•: this rr.•
`move~ l,h~ <11\or 11ml modlflc11 t,ho color. Soltwliw Kr1lv<1111>1 or<• 111110
`11;_111wLimuK umployl!d t•> ,,x1.r,1d i11)J)l1rillc1K.
`II, hl\t bc(ln fo111id 1,h11\. lh<1 11xuu11. ot' purlfic<,l,io11 rnquircd t.o
`prnd,,,,., r•,,uo/11111111 und l.i///l.l Mi11m·c1/ Oil or officinl qttnlit.y r<•·
`m (,.,~K n11fi<>xl<l11ntu f,hlll 11r(1 ni,~urully prt!Malll-, ml1I 1.lu, 1111rifinll
`1>1·od11ci subsoqulln~ty ho• 11 to11ch111cy to oxidii.c mid d!?v<)IOI> ,m
`offo1111iv1) o,lor. ThiK iij prnv1mt1,d hy 1.h,, 111ltlitiu11 nf 11 111in11(.o
`<1111111WN tJf <•·•·locophorol, or othor 1mit11hle untioxid1111r., ,1~ (ij now
`pi,rrniH11ihl<1.
`DOH(U'it1i,i1m, -lhwt,,1111J~ 111tl~$ ,1r y1,lfowiRh 10 li11hf, 11mb111' 1:o)nl'; w,c.
`111m·11 th11n n uli11h1. f11101·011r.1111r:c, nJ'u,·r bc,l111t 11w1u,d; 1.rm1~pnrt1111. in thlu
`l11yol'II: fl't•<• ,,1· m,11rly fre,, f>·<.>m ,,.1(., 1111<1 timte; .,,.,cit'iti 1c>•nvlty O.Hrn to
`O.MsO nl (l(I• ; moll11 ho1.w11011:.n1 1111<160°.
`Solubllity .... l11~,il11hl1, in w,11.t1r; ulmo•t i1111olul>lo in <:ol([ (11• hot. ~kohol
`of hi ;1<1ltl dohytl rnf,lld 111t:,1h1ll: fr1);,I:,, Hl)l11hl11 h1 ho111,t11111, ,,11tl)(m lli11111fidc,
`dilomform <II' tun11111fi1i,1 ull; x1)1\11)lc in uthct, •s•1lv<111(. h1,~1111" ,,1• ill 11111•1-
`flxod 111111 volnt,lh• oil11, f,hu 1l11Mrn<• nf'•olul,ilit,y in tllo~r: 1J()lv,mt.: v11ryi111t
`will, (.1\1) ClllllllOKitiorl of lh(! Jl~l.1·11!11t11m.
`
`It. i11 ili11hly 11cduijiw om! tlwrnfor<'
`ll1HIN••··--t\ bMc for vintmolllN.
`i1111md (lmolli~nt. hul H. n