Curriculum Vitae
`
`Prepared 10/2021
`
`Edward A. Fisher, M.D., M.P.H., Ph.D.
`
`Office Address:
`New York University School of Medicine
`NSB-7
`435 E. 30th St.
`New York, NY 10016
`Phone: 212-263-6636; Fax: 212-263-9115; e-mail: edward.fisher@nyumc.org
`
`Place of birth: New York City
`
`EDUCATION
`
` 1967
` 1971
` 1975
` 1978
` 1982
`
`2010
`
`POSTDOCTORAL TRAINING
`
` 1975 - 1977
`
` 1978 - 1981
`
` 1978 - 1981
`
` 1981 - 1984
`
`1994
`
`Bronx High School of Science
`B.A. Harpur College, State Univ. of N.Y.
`M.D. New York University School of Medicine
`M.P.H. University of North Carolina
`Ph.D. Massachusetts Institute of Technology
`Thesis Area: Apolipoprotein E Metabolism
`Advisors: Drs. Jan L. Breslow, Nevin Scrimshaw
`M.A. University of Oxford
`
`Pediatric Resident, Duke Hospital, Durham, NC;
`07/01/75-06/30/77
`
`Fellowship, Division of Metabolism and Division of
`Gastroenterology
`and Nutrition, Children's
`Hospital, Boston, MA (affiliate of Harvard Medical
`School); 09/01/78-06/30/81
`
`Fellowship, Clinical Research Center, MIT
`Cambridge, MA; 09/01/78-06/30/81
`
`Medical Staff Fellow in Human Genetics, National
`Institutes of Health, Bethesda, MD - molecular
`biology research training in laboratory of Dr. Gary
`Felsenfeld; 07/01/81-08/31/84
`
`leave, Laboratory of Cell Biology
`Sabbatical
`(Rockefeller Univ.) with Dr. Günter Blobel;
`01/02/94-06/30/94
`
`1
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`

`

`
`2019
`
`
`1981
`1996-
`
`
`CERTIFICATION/LICENSURE
`
`
`
`
`ACADEMIC APPOINTMENTS
`
`Present:
`
`
`
`
`
`
`
`Bioinformatics training course and visiting scholar,
`Cambridge University; 1/2019-3/2019
`
`American Board of Pediatrics certification
`New York State medical license
`
`The Leon H. Charney Professor of Cardiovascular
`Medicine; Professor of Medicine (Cardiology),
`Pediatrics, and Cell Biology; Director, Marc and
`Ruti Bell Vascular Biology and Disease Program;
`Founding Director and current Director of
`Translational Research, Center for the Prevention of
`Cardiovascular Disease; Adjunct Faculty, and
`Rockefeller University, N.Y.; Visiting Professor,
`Department of Cardiovascular Medicine, University
`of Oxford
`
`
`Eastman Professor, University of Oxford and
`Fellow, Balliol College.
`
`Professor of Medicine, Director, Section of
`Lipoprotein Research, Cardiovascular
`Institute;
`Professor,
`Depts.
`of
`Pediatrics
`and
`Biochemistry/Molecular Biology, The Mount Sinai
`School of Medicine, N.Y.; Adjunct Faculty,
`Rockefeller University, N.Y.
`
`Past:
`
`2010-2011
`
`
`1999-2003
`
`
`1998-1999
`
`
`
`
`
`
`
`
`
`1996-1998
`
`
`
`
`
`
`
`
`1994-1995
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Director of Lipoprotein Research, Cardiovascular
`Institute, and Associate Professor of Medicine,
`Pediatrics, Physiology/Biophysics, and Cell
`Biology/Anatomy, The Mount Sinai School of
`Medicine; Adjunct Faculty, Rockefeller University
`
`Director of Lipoprotein Research, Cardiovascular
`Institute, and Associate Professor of Medicine &
`Pediatrics, The Mount Sinai School of Medicine,
`NY, NY Adjunct Faculty, Rockefeller University
`
`Associate Professor of Biochemistry, Pathology and
`Pediatrics, Medical College of Pennsylvania;
`Adjunct Associate Professor
`of Pediatrics,
`University of Pennsylvania; Adjunct
`faculty,
`Laboratory of Cell Biology, The Rockefeller
`University, NY, NY
`
`
`
`
`
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`

`1993-1994
`
`
`1992 - 1993
`
`
`1991 - 1992
`
`
`1988 - 1991
`
`
`
`1987 - 1992
`
`
`
`
`
`1987 - 1988
`
`
`
`
`
`1984 - 1987
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1991 - 1995
`
`
`1992 - 1995
`
`
`1997- 2003
`
`
`2003-2006
`
`
`
`
`
`HOSPITAL AND ADMINISTRATIVE APPOINTMENTS
`
`1984 - 1987
`
`Associate Professor of Biochemistry, Pathology and
`Pediatrics, Medical College of Pennsylvania;
`Adjunct Associate Professor
`of Pediatrics,
`University of Pennsylvania
`
`Associate Professor of Biochemistry and Pediatrics,
`Medical College of Pennsylvania, PA; Adjunct
`Associate Professor of Pediatrics, University of
`Pennsylvania
`
`Associate Professor of Biochemistry and Pediatrics,
`The Medical College of Pennsylvania
`
`
`Assistant Professor of Biochemistry and Medicine
`The Medical College of Pennsylvania
`
`Adjunct Assistant Professor of Pediatrics
`University of Pennsylvania School of Medicine
`Philadelphia, PA
`
`Assistant Professor of Biochemistry
`The Medical College of Pennsylvania
`Philadelphia, PA
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Assistant Professor of Pediatrics
`Division)
`University of Pennsylvania School of Medicine
`Philadelphia, PA
`
`(Genetics
`
`
`
`Attending physician, Department of Medicine,
`Nutrition Support Service, Children’s Hospital of
`Philadelphia
`
`Medical Staff, Medical College of PA Hospital and
`Co-director, Cardiovascular Risk Reduction Clinic,
`Department of Pediatrics, The Medical College of
`Pennsylvania
`
`Co-director, Molecular Diagnostic Laboratory,
`Department of Pathology, The Medical College of
`Pennsylvania
`
`Attending physician, Departments of Medicine and
`Pediatrics (Lipid Reduction Clinic), Mount Sinai
`Medical Center
`
`Attending Physician, Departments of Medicine and
`Pediatrics, Bellevue and Tisch Hospitals (NYU
`Medical Center)
`
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`

`
`2003-
`
`
`2003-2019
`
`
`2006-
`
`
`2008-2010
`
`2019-
`
`
`
`2007-2012
`
`
`
`OTHER PROFESSIONAL POSITIONS
`
`
`
`Director, Marc and Ruti Bell Vascular Biology and
`Disease Program
`
`the Prevention of
`Director, NYU Center for
`Cardiovascular Disease (prior to 2006, called NYU
`Lipid Treatment and Research Center)
`
`Attending Physician, Departments of Medicine and
`Pediatrics, Tisch Hospital (NYU Medical Center);
`
`Co-Director, Translational Research, NYU CTSI
`
`Director of Translational Research, NYU Center
`for the Prevention of Cardiovascular Disease
`
`
`
`
`AWARDS AND HONORS
`
`
`
`1967 - 1975
`
`
`
`
`1968
`
`
`1969 - 1970
`
`1971
`
`
`
`1991
`
`1992, 1998
`
`
`1992
`
`
`1995-1996
`
`
`
`
`
`Editor-in-Chief,
`then
`Editor,
`Associate
`Arteriosclerosis, Thrombosis, & Vascular Biology
`(ATVB), an American Heart Association journal
`
`
`
`
`
`Varsity Letters in Track
`New York State Regents Scholarships and Scholar
`Incentive Awards (in college and medical school)
`
`Company
`Rubber
`Chemical
`Undergraduate Chemistry
`
`Award
`
`in
`
`Honors Program in Spanish Literature
`
`"Distinguished Independent Work in the Division of
`Science and Mathematics" (Advisor: Dr. Charles
`Houghton)
`
`Merck Young Investigator Award
`
`Visiting Professor, Department of Pathology and
`Laboratory Medicine, University of Rochester
`
`Visiting Professor, Department of Biochemistry,
`University of Rennes (France)
`
`President, New York Lipid Research Club
`
`4
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`

`

`
`2000
`
`2001
`
`2003-
`
`2004
`
`2005
`
`Dean’s Lecturer, Mount Sinai
`
`Session Chair, Gordon Research Conference on
`Lipoprotein Metabolism
`
`in
`The Leon H. Charney Professorship
`Cardiovascular Medicine, NYU School of Medicine
`
`Invited Professor, University of Nancy, France
`
`Faculty inductee, AOA (medical school honor
`society) chapter of NYU School of Medicine
`
`2005
`
`
`
`
`
`Elected to the Interurban Clinical Club
`
`2005
`
`
`2007
`
`
`2007
`
`
`2007-2011
`
`
`2008
`
`
`2009
`
`2010-2011
`
`2011
`
`2012
`
`2012
`
`2012
`
`
`2013
`
`Lecture-
`Ruth Gray Memorial
`Hospital/Northwestern Healthcare
`
`Evanston
`
`Solomon A. Berson Award for Basic Science
`Achievement (highest academic award
`to an
`alumnus of the NYU School of Medicine)
`
`Pfizer/ACC Visiting Professor
`Cardiology, University of Virginia
`
`in Preventive
`
`Editor-in-Chief,
`then
`Editor,
`Associate
`Arteriosclerosis, Thrombosis, Vascular Biology
`
`Special Recognition Award in Arteriosclerosis,
`American Heart Association/Arteriosclerosis,
`Thrombosis, Vascular Biology Council
`
`Elected to the American Association of Physicians
`
`George Eastman Professor, Oxford University
`
`Chair, Gordon Research Conference
`Atherosclerosis
`
`on
`
`Chair, Keystone Symposium on Atherosclerosis
`
`
`
`
`
`
`
`Dean’s Lecture, NYU School of Medicine
`
`to
`Elected
`Cardiologists
`
`the Association of University
`
`The George Lyman Duff Lecture (delivered at the
`Annual Scientific Sessions of the American Heart
`Association), American Heart Association/ATVB
`Council
`
`5
`
`
`
`
`
`
`
`
`
`
`
`
`
`
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`Hikma Pharmaceuticals
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`IPR2022-00215
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`Ex. 1047, p. 5 of 48
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`

`

`
`2014
`
`
`2014
`
`
`2016
`
`
`2016
`
`
`2017
`
`
`2018
`
`
`2018
`
`
`2019
`
`
`2021
`
`
`2021
`
`
`
`
`24th Annual Daniel Memorial Lecture, Baylor
`College of Medicine/Texas Heart Institute, Houston
`
`The Frank Tyler Honorary Endowed Lecture,
`University of Utah School of Medicine, Salt Lake
`City
`
`
`Lifetime Achievement Award for “remarkable
`accomplishments
`in
`the field of
`lipidology”,
`National Lipid Association
`
`Lipid
`Southeast
`Lecture,
`Brown
`Virgil
`Club/University of Kentucky Cardiovascular Day
`
`Hugh Sinclair Memorial Lecture, Cambridge
`University
`
`David Rubenstein Lecture, Canadian Lipoprotein
`Annual Conference, Toronto
`
`Distinguished Achievement Award, American
`Heart Association/ATVB Council (Highest honor of
`Council)
`
`Distinguished Visiting Scholar, University of
`Birmingham (UK)
`
`Pioneer in Cardiology Award for Unsurpassed
`Contributions to Cardiovascular Science, Medical
`University of Graz (Austria)
`
`Willard J. and Priscilla F. Visek Lecture, University
`of Illinois (Nutrition Dept.)
`
`
`
`MAJOR COMMITTEE ASSIGNMENTS
`
`
`Medical Scientist Training Program (MD/PhD Program) Admissions Committee
`Department of Pediatrics Chair Search Committee 2004-05, 2007
`Department of Microbiology/Immunology Chair Search Committee, 2015
`Department of Medicine Finance Sub-Committee 2005
`Co-chair, Cardiovascular Biology Research Program recruitment committee
`2004-
`Mentoring and thesis committees, Department of Medicine and Sackler Graduate
`School of NYU
`Co-chair, Faculty Research Bridge Funding Committee
`
`6
`
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`

`
`MEMBERSHIPS, OFFICES, AND COMMITTEE ASSIGNMENTS IN
`PROFESSIONAL SOCIETIES
`
`
`1993 -2000
`
`Member, Committee on Atherosclerosis and Hypertension in
`Children, American Heart Association
`
`Member, Nutrition Committee, American Heart Assoc. and the
`Executive Committee, Council on Cardiovascular Disease in the
`Young, American Heart Assoc.
`
`
`
`President, NY Lipid Research Club
`
`
`1993-2000
`
`
`1995-1996
`
`2000-
`
`Member, American Heart Association National Spokespersons
`Panel
`
`Fellow of the American Heart Association (FAHA)
`
`Board of Directors, Northeast section, National Lipid Association
`
`Elected to the American Association of Physicians
`
`Elected to the Association of University Cardiologists
`
`Lifetime member, National Lipid Association
`
`External Advisory Board, Dept. of Nutrition, Univ. Of Illinois
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`2002
`
`2007-2009
`
`2009
`
`2012
`
`2016-
`
`2021-
`
`EDITORIAL BOARDS AND OTHER REVIEW ACTIVITIES
`
`
`
`Member, Lipid and Lipoprotein Metabolism Peer Review Committee, American
`Heart Association (National Office), Dallas, TX, 1991 –1994; 1999-2000; 2005
`
`Member - Research Council, American Heart Association, New York City
`Affiliate, 1987 - 1989
`
`Reviewer, Program Committee for the Scientific Sessions, American Heart Assoc.
`(1995-)
`
`Manuscripts - ad hoc: Am. J. Pathology, J. Experimental Medicine, J. Am. Coll.
`Cardiology, Diabetes, PNAS, Biochemistry, Cell Metabolism, Nature, Nature
`Medicine.
`
`Grants and site visits for USDA, NIH (sites visits and frequent ad hoc member of
`Study Sections)
`
`Editorial Board - Proceedings of the Soc. for Experimental Biology and Medicine,
`1992-1998
`
`
`7
`
`
`
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`

`Editorial Board- Journal of Lipid Research, 1998-2007; 2018-
`
`Editorial Board- Journal of the American College of Nutrition, 2000-2003
`
`Editorial Board, Journal of Biological Chemistry, 2002-2007
`
`Editorial Board, Journal of Clinical Investigation, 2005-
`
`Guest Editor, Circulation and Circulation Research, 2007- 2015, 2019-
`
`Associate editor, Arteriosclerosis, Thrombosis, & Vascular Biology (a journal of
`the American Heart Association); editor for manuscripts in the area of
`atherosclerosis/lipoprotein metabolism, 2007-2011
`
`Editor in Chief, Arteriosclerosis, Thrombosis & Vascular Biology, 2011-2012,
`then member of editorial board 2012-
`
`Member, Integrated Nutrition and Metabolic Processes (INMP) NIH Study
`Section, 2009-2015
`
`Editorial Board, Annual Review of Nutrition, 2009-2015
`
`Editorial Board, Journal of Clinical Lipidology, 2017-
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`ADVISORY BOARDS
`
`
`Member, External Advisory Board, NIH Program Project Grant directed by Dr.
`Jan Breslow (Rockefeller University), 2000-2005
`
`Member, External Advisory Board, NIH Program Project Grant directed by Dr.
`Ira Tabas and Dr. Alan Tall (Columbia P&S), 2006-2010
`
`Member, Advisory Board, Cardiovascular Research Institute, University of
`Rochester Medical Center, 2009-
`
`Member, External Advisory Board, NIH Program Project Grant directed by Dr.
`Stephen Young (UCLA), 2010-2012
`
`Takeda Advisory Board on Diabetes, 2007-2010
`
`Merck Global Advisory Board in Atherosclerosis, 2010-2014
`
`External Advisory Board, Dept. of Nutrition, Univ. of Illinois, 2021-
`
`
`
`
`8
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`

`

`MAJOR RESEARCH AND CLINCIAL INTERESTS
`
`
`Lipoprotein metabolism, overnutrition/cardiometabolic diseases, vascular biology,
`atherosclerosis, imaging, preventive cardiology
`
`
`
`PRINCIPAL CLINICAL AND HOSPITAL SERVICE RESPONSIBILITIES
`
`1984-1987 Attending physician, Children’s Hospital of Philadelphia; co-director,
`nutrition support service; attending, general medical service
`
`
`1989-1995 Attending physician, pediatrics, Medical College of Pennsylvania
`Hospital; attending and co-director of cardiovascular risk reduction clinic
`(Dept. of Pediatrics)
`
`
`1992-1995
`
`Co-director, Molecular Diagnostic Laboratory, Dept. of Pathology,
`Medical College of Pennsylvania
`
`
`1997-2003 Attending physician, medicine and pediatrics, Mount Sinai Hospital;
`attending, lipid management clinic (Cardiology Division/Dept. of
`Medicine)
`
`
`2003-
`
`Attending Physician, Departments of Medicine and Pediatrics, Tisch
`Hospital (NYU Medical Center); Director, NYU Lipid Treatment and
`Research Center (renamed the Center for the Prevention of Cardiovascular
`Disease in 2006)
`
`
`MAJOR ADMINSTRATIVE RESPONSIBILITIES
`
`Director, Marc and Ruti Bell Vascular Biology and Disease Program (a basic science
`program; NYU School of Medicine)
`
`Director of Translational Research, Center for the Prevention of Cardiovascular Disease
`(a clinical treatment and research program; NYU School of Medicine)
`
`
`TEACHING ACTIVITIES (INCLUDING TRAINING RECORD)
`
`
`Courses:
`Preceptor, Research Journal Club, Dept. of Medicine Residency Program 2005-
`Lecturer, Core Curriculum, Cardiology Fellowship 2004-
`Lecturer, Cell Biology Course, NYU School of Medicine 2006-
`Lecturer, Cardiovascular Pathophysiology Course, NYU School of Medicine
`2006-
`Lecturer, Biochemistry Course, NYU School of Medicine 2008-
`Lecturer, Pathobiology training program, NYU School of Medicine 2014-
`
`
`Graduate Students:
`Robert Hepler 1987 - 1990 (MS; technician at Merck)
`Joseph Bass 1988 - 1990 (MD/PhD; Endowed Professor and chief of
`Endocrinology, Northwestern University)
`
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`

`Emma Kummrow 1992 - 1996 (PhD; consultant in Philadelphia)
`Robin Choudhury 1999-2001 (for Doctor of Medicine thesis, Oxford University;
`currently Professor, Dept. of Cardiovascular Medicine, Oxford)
`Eugene Trogan 2000-2004 (PhD; Bristol Myers/Squibb executive)
`Jonathan Feig 2004-2009 (MD/PhD program; cardiology practice, NY)
`Karishma Rahman 2013-2017(MD/PhD student; internal medicine resident,
`Mount Sinai, NY)
`Tatjana Josefs 2014-2019 (post-doctoral fellow, Amsterdam Medical Center)
`Hussam Alkaissi 2018-2019 (internal medicine resident, Downstate Medical
`Center, NY)
`Maria Laskou 2020-
`
`Postdoctoral fellows:
`Dr. Reza Zolfaghari 1988 - 1991 (research associate professor of nutrition, Penn
`State)
`Dr. Hongxing Wang 1990 - 1993 (senior research scientist, Astra-Zeneca
`Pharmaceuticals)
`Dr. Xiaoli Chen 1990 - 1993 (Professor of pathology, Medical College of
`Pennsylvania)
`Dr. Kelly Morlock 1991 - 1992 (senior staff scientist, Neose Pharmaceuticals)
`Dr. Hyun Sook Lee 1992 - 1993 (associate professor, Women's Univ., Korea)
`Dr. Ranaan Shamir 1993 -1995 (Director of Gastroenterology/Nutrition Institute,
`Schneider Children’s Hospital, Professor of Pediatrics, Sackler School of
`Medicine, Israel)
`Dr. Mohamed Zaiou 1993-1995 (research scientist, University of Nancy, France)
`Dr. Ling Li 1995-1996 (Endowed Professor, Univ. of Minnesota)
`Dr. Raji Pariyarath 1997-2000 (Pharmaceutical industry, Italy)
`Dr. Jun Kusunoki 1998-2000 (senior research scientist, Banyu Pharmaceutical
`Co.[Japanese division of Merck])
`Dr. Newsha Ghodsi 1999-2000 (cardiology attending, Mount Sinai)
`Dr. Victoria Gusarova 1999-2006 (staff scientist, Regeneron)
`Dr. James Rong 1999-2004 (senior scientist, Eli Lilly)
`Dr. Meihui Pan 2000-2004 (senior research scientist, Novartis)
`Dr. Tonia Kim 2001-2003 (assistant professor of medicine, Mount Sinai)
`Dr. Hilke Wientgen 2001-2002 (endocrinologist, Germany)
`Dr. Nicola Kreglinger 2002-2005 (Endocrinologist, NY)
`Dr. Sandra Soler 2003-2004 (Attending cardiologist, Bronx VA Hospital)
`Dr. Yanqing Ma 2004-2007 (résident in médicine, Staten Island University
`Hospital)
`Dr. Stephanie Mick 2005-2007 (Attending cardiac surgeon, Cleveland Clinic)
`Dr. Jeonmin Seo 2005-2007 (teaching position, Korea)
`Dr. Vatsala Maitin 2004-2007 (assistant professor, Texas State College, San
`Marcos)
`Dr. Linda Shang 2007-2008 (post-doctoral fellow, Albert Einstein, NY)
`Dr. Alessandra Barazza 2007-2009 (staff scientist, Bristol Myers/Squibb)
`Dr. Doru Chirieac 2007-2009 (Research Associate, UMDNJ)
`Dr. Chuyun Yuan 2007-2010 (Psychiatry resident, Winthrop University Hospital)
`Dr. Steven Meex, 2008-2009 (clinical chemistry faculty, Maastrict University,
`Netherlands)
`Dr. Noemi Rotllan 2010-2011 (post-doctoral fellow, Yale School of Medicine)
`Dr. Saj Parathath 2005-2011 (staff scientist, Merck)
`
`10
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`

`

`(Medical Associate, Health Science
`
`Dr. Ursula Andreo 2007-2011 (research associate, Rockefeller University)
`Dr. Marie Sanson 2008-2011 (medical writer, France)
`Dr. Maria Darvari 2009-2011 (post-doctoral fellow, Medical University of
`Vienna)
`Dr. Stewart Russell 2009-2012 (instructor, City College of NY)
`Dr. Bernd Hewing, 2010-2012 (cardiology fellow, Free University of Berlin)
`Dr. Tadateru Hamada 2011-2012 (staff scientist, Shionogi and Co., Japan)
`Dr. Ana Tuyama, 2011-2012 (GI practice, Westchester NY)
`Dr. Pui Butkinaree 2011-2012 (Lecturer, Chulabhorn Graduate Institute,
`Bangkok, Thailand)
`Dr. Yuliya Vengrenyuk 2009-2013 (Assistant Prof., Cardiology, Mount Sinai
`School of Medicine)
`Dr. Charles Guo 2009-2014 (staff scientist, CV Pathology Institute)
`Dr. Emilie Distel 2010-2014 (staff scientist, Université Paris Descartes, France)
`Dr. Orli Even-Or 2011-2014 (staff scientist, biotechnology company in Israel)
`Dr. Yuan Yang 2011-2012 (staff scientist, Peking University)
`Dr. Hitoo Nishi 2012-2016 (Associate Prof. of Medicine/Cardiology, Kyoto
`Univ. ; Deceased 8/18)
`Dr. Arjun Menon 2012-2015 (Associate, Healthcare Consultancy Group, NY)
`Dr. Michael Peled 2013-2014 (post-doctoral fellow, NYU School of Medicine)
`Dr. Maria Coimbra 2013-2014 (staff scientist, biotechnology company,
`Netherlands)
`Dr. Prashanthi Menon 2013-2015
`Communications, NY)
`Dr. JaimeAmengual-Terrasa 2013-2016 (Assist. Prof., U. Illinois)
`Dr. Sean Heffron 2014-2016 (Assist. Prof., Dept. Med./Cardiology, NYU)
`Dr. Tessa Barrett 2012-2016 (Assist. Prof., NYU School of Medicine)
`Dr. Sonia Bergaya 2016-2018 (lost contact with)
`Dr. Haizhen Wang 2015-2018 (Laboratory director, China)
`Dr. Beyza Vurusaner-Atkas 2017-2019
`Dr. Shruti Rawal 2017-2019 (post-doctoral fellow, Harvard Medical School)
`Dr. Ozlem Tufanli-Kireccibasi 2017-
`Dr. Ada Weinstock 2015-
`Dr. Prashanth Thevkar Nagesh 2017-2020 (post-doctoral fellow, Harvard Medical
`School)
`Dr. Elona Dautaj 2018-2020
`
`Dr. Chao Xue 2018-2019 (visiting scholar from China)
`Dr. Bianca Scolaro 2019-
`Dr. Carmen Hannemann 2020-
`Dr. Maria Nacher 2021-
`Dr. Franziska Krautter 2021-
`
`GRANT SUPPORT
`
`P01HL131481 (E. Fisher, PI)
`05/01/2017 – 04/30/22
`
`
`
`
`
`NIH/NHLBI
`
`
`
`Macrophage dysfunction in obesity, diabetes and atherosclerosis
`
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`IPR2022-00215
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`Ex. 1047, p. 11 of 48
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`P01HL131478 (E. Fisher, co-I)
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`03/17/2017 – 02/28/2022
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`NIH/NHLBI
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`Stress and atherosclerosis plaque macrophages
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`R01HL153712 (E. Fisher, co-I)
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`08/20/2020 – 07/31/2025
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`NIH/NHLBI
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`Dissecting the role of CD8+ T cells in atherosclerosis
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`20SFRN35210936 (E. Fisher, PI)
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`01/01/2020 – 12/31/2023
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`AHA SFRN Center Program 20SFRN35210245
`Mechanisms that retard atherosclerosis regression in insulin resistant and obese mice
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`R01HL084312 (E. Fisher, PI)
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`04/01/2021 – 03/31/2025
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`NIH/NHLBI
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`Molecular regulation of atherosclerosis regression
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`P01HL151328 (E. Fisher, co-I)
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`08/15/2020 – 07/31/2025
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`NIH/NHLBI
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`Triglycerides, Diabetes and Cardiovascular Disease
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`PUBLICATIONS
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`A. Peer-reviewed original investigations:
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`1.
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`Smith, A.B. and Fisher, E. Statistical assessment of chemical effects on human
`reproduction. New Zealand Statistician 15: 12-16, 1980.
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`Fisher, E. and Gahl, W. Cysteamine in treatment of type III hyperlipidemia.
`Lancet II 8308: 1131-1132, 1982.
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`Fisher, E., Blum, C., Zannis, V. and Breslow, J. Independent effects of dietary
`saturated fat and cholesterol on plasma lipids, lipoproteins, and apolipoprotein E.
`J. Lipid Res. 24: 1039-1048, 1983.
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`Gahl, W.A., Gregg, R.E., Hoeg, J.M. and Fisher, E. In vivo alteration of a mutant
`human protein using the free thiol cysteamine. Am. J. Med. Genet. 20: 409-417,
`1985.
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`Fisher, E. and Felsenfeld, G. Comparison of the folding of ß-globin and
`ovalbumin gene containing chromatin isolated from chicken oviduct and
`erythrocytes. Biochemistry 25: 8010-8016, 1986.
`
`Fisher, E., Carroll, R., Cortner, J., and Surrey, S. Transcriptional activity of the
`genes for apoproteins A-I and E in the neonatal rat liver. Atherosclerosis 68:
`249-253, 1987.
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`12
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`3.
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`6.
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`Hikma Pharmaceuticals
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`IPR2022-00215
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`Ex. 1047, p. 12 of 48
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`Fisher, E., Jung, A., and Cortner, J. Artifacts in RFLP analyses of human DNA
`samples co-precipitated with t-RNA. Clinical Chemistry 33: 2304-2305, 1987.
`
`Fisher, E., Anbari, A., Klurfeld, D., and Kritchevsky, D. Independent Effects of
`Diet and Nutritional Status on Apoprotein B Gene Expression in Rabbit.
`Arteriosclerosis 8, 797-803, 1988.
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`Kritchevsky, D., Tepper, S.A., Davidson, L.M., Fisher, E., and Klurfeld, D.M.
`Experimental atherosclerosis: interaction of animal and vegetable protein with
`saturated or unsaturated fat. Atherosclerosis 75: 123-127, 1989.
`
`Fisher, E. Change in chromatin organization of the 3'-flanking region of the rat
`apoprotein E gene in neonatal rats after an increase in transcriptional activity.
`Atherosclerosis 76: 29-33, 1989.
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` Comparative effects of
`12. Wong, S.H., Fisher, E.A., and Marsh, J.B.
`eicosapentaenoic and docosahexaenoic acids on apoB messenger RNA and
`secretion of newly synthesized VLDL in HepG2 cells. Arteriosclerosis 9: 836-
`841, 1989.
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`7.
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`8.
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`9.
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`10.
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`13.
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`Zolfaghari, R., Harrison, E.H., Ross, A.C., and Fisher, E.A. Expression in
`Xenopus oocytes of rat liver mRNA coding for bile salt-dependent cholesteryl
`ester hydrolase. Proc. Natl. Acad. Sci. USA 86: 6913-6916, 1989.
`
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`14. Williams, K.J., Brocia, R.W., and Fisher, E.A. The unstirred water layer as a site
`of control of apolipoprotein B secretion. J. Biol. Chem. 265: 16741-16744, 1990.
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`15.
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`16.
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`17.
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`18.
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`19.
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`Bass, J., Fisher, E.A., Prack, M.M., Williams, D.L., and Marsh, J.B.
`Macrophages from nephrotic rats regulate apolipoprotein E biosynthesis and
`cholesterol content independently. J. Clin. Invest. 87: 470-475, 1991.
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`Sparks, J.D., Zolfaghari, R., Sparks, C.E., Smith, H., and Fisher, E.A. Impaired
`hepatic apolipoprotein B and E translation in streptozotocin diabetic rats. J. Clin.
`Invest. 89: 1418-1430, 1992.
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`Zolfaghari, R., Harrison, E.H., Han, J.H., Rutter, W.J., and Fisher, E.A. Tissue
`and species differences in bile salt-dependent cholesteryl esterase activity and
`gene expression. Arteriosclerosis and Thrombosis 12: 295-301, 1992.
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`Aalto-Setala, K., Fisher, E.A., Chen, X., Chajek-Shaul, T., Hayek, T., Zechner,
`R., Walsh, A., Ramakrishnan, R., Ginsberg, H.N., and Breslow, J.L. Mechanism
`of hypertriglyceridemia in human apolipoprotein(apo)CIII transgenic mice:
`Diminished VLDL fractional catabolic rate associated with increased apo CIII and
`reduced apo E on the particles. J. Clin. Invest. 90: 11889-11900, 1992.
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`Furth, E., Sprecher, H., Fisher, E.A., Fleishman, H.D., and Laposata, M. An in
`vitro model for essential fatty acid deficiency: HepG2 cells permanently
`maintained in lipid-free medium. J. Lipid Res. 33: 1719-1726, 1992.
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`20. Wang, H., Chen, X., and Fisher, E.A. N-3 fatty acids stimulate intracellular
`degradation of apoprotein B in rat hepatocytes. J. Clin. Invest. 91: 1380-1389,
`1993.
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`Zolfaghari, R., Glick, J.M., and Fisher, E.A. The effects of varying the
`expression of a neutral cholesteryl ester hydrolase on the turnover of cholesteryl
`ester in rat hepatoma cells. J. Biol. Chem. 268: 13532-13538, 1993.
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`Zolfaghari, R., Chen, X., and Fisher, E.A. Simple method for extracting RNA
`from cultured cells and tissue with guanidine salts. Clin. Chem. 39: 1408-1411,
`1993.
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`Chen, X., Sparks, J.D., Yao, Z., and Fisher, E.A. Hepatic polysomes that contain
`apoprotein B mRNA have unusual physical properties. J. Biol. Chem. 268:
`21007-21013, 1993.
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`Reisher, S., Fisher, E.A., and Feinstein, S.I. Rabbit and rat liver nuclei both
`contain proteins which bind to the regions controlling apolipoprotein A-I gene
`expression. Eur. J. Biochem. 216: 247-253, 1993.
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`25. Wang, H., Yao, Z., and Fisher, E.A. The effects of n-3 fatty acids on the
`secretion of carboxy-truncated forms of human apoprotein B. J. Biol. Chem.
`269: 18514-18520, 1994.
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`21.
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`22.
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`23.
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`24.
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`26.
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`Heinemann, T., Metzger, S., Fisher, E.A., Breslow, J.L., and Huang, L.
`Alternative polyadenylation of apolipoprotein B RNA is a major cause of B-48
`protein formation in rat hepatoma cell lines transfected with human apoB-100
`minigenes. J. Lipid Res. 35:2200-2211, 1994.
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`27. Morlock-Fitzpatrick, K.R., and Fisher, E.A. The effects of O- and N-linked
`glycosylation on the secretion and bile salt-stimulation of pancreatic carboxy ester
`lipase activity. Proc. Soc. Exp. Biol. Med. (P.S.E.M.) 208:186-190, 1995.
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`28.
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`29.
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`30.
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`31.
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`Shamir, R., Johnson, W.J., Zolfaghari, R., Lee, H.S., and Fisher, E.A. Role of
`bile salt-dependent cholesteryl ester hydrolase in the uptake of micellar
`cholesterol by intestinal cells. Biochemistry 34:6351-6358,1995.
`
`Burkey, B.F., France, D., Wang, H., Ma, X., Nottage, B., Kowal, C., Diffenderfer,
`M., Marsh, J.B., Paterniti, J.R., and Fisher, E.A. Overexpression of human
`apolipoprotein A-I in transgenic rats and the hyperlipoproteinemia associated with
`experimental nephrosis. J. Lipid Res.36:1463-1473, 1995.
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`Azrolan, N., Odaka, H., Breslow, J.L., and Fisher, E.A. Dietary fat elevates
`hepatic apoA-I production by increasing the fraction of apolipoprotein A-1
`mRNA in the translating pool. J. Biol. Chem. 270:19833-19838, 1995.
`
`Shamir, R., Johnson, W.J., Morlock-Fitzpatrick, K., Zolfaghari, R., Li, L., Mas,
`E., Lombardo, D., Morel, D.W., and Fisher, E.A. Pancreatic carboxyl ester
`lipase: A circulating enzyme that modifies normal and oxidized lipoproteins in
`vitro. J.Clin.Invest. 97:1696-1704, 1996.
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`32. Marsh, J.B., Diffenderfer, M.R., Fisher, E.A., Sowden, M., Dong, M., Paterniti,
`J.R., and Burkey, B. F. Effect of experimental nephrosis on hepatic lipoprotein
`secretion and urinary lipoprotein excretion in rats expressing the human
`apolipoprotein A-I gene. J. Lipid Res. 37:1113-1124, 1996.
`
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`33. Werth, V.P., Williams, K.J., Fisher, E.A., Bashir, M., Rosenbloom, J., and Shi, X.
`UVB irradiation alters cellular responses to cytokines: role in extracellular matrix
`gene expression. J. Invest. Derm. 108:290-294, 1997.
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`Chen, X., Harrison, E.H., and Fisher, E.A., Molecular cloning of the cDNA for rat
`hepatic, bile salt-dependent cholesteryl ester hydrolase demonstrates identity with
`pancreatic carboxylester lipase. Proc. Soc. Exp. Biol. Med. (P.S.E.M.) 215:186-
`191, 1997.
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`Fisher, E.A., Zhou, M., Mitchell, D.M., Wu, X., Omura, S., Wang, H., Goldberg
`A.L., and Ginsberg, H.N. The degradation of apolipoprotein B100 is mediated by
`the ubiquitin-proteasome pathway and involves heat shock protein 70. J. Biol.
`Chem. 272:20427-20434, 1997.
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`Zolfaghari, R., Shamir, R., Fisher, E.A. Properties of pancreatic carboxyl ester
`lipase in mRNA-injected Xenopus oocytes and transfected mammalian hepatic
`and intestinal cells. Methods in Enzymology 286:80-101, 1997.
`
`Fuki, I., Kuhn, K.M., Lomazov, I.R., Rothman, V.L., Tuszynski, G.P., Iozzo,
`R.V., Swenson, T.L., Fisher, E.A., and Williams, K.J The Syndecan Family of
`Proteoglycans: Novel Receptors Mediating Internalization of Atherogenic
`Lipoproteins In Vitro. J. Clin. Invest. 100:1611-1622, 1997.
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`Bruneau, N., Nganga, A., Fisher, E.A., and Lombardo, D. O-glycosylation of C-
`terminal tandem-repeated sequences regulates the secretion of rat pancreatic bile-
`salt dependent lipase. J. Biol. Chem. 272:27353-27361, 1997.
`
`Zaiou, M., Azrolan, N., Hayek, T., Wang, H., Wu, L., Haghpassand, M., Cizman,
`B., Madaio, M.P., Milbrandt, J., Marsh, J., Breslow, J.L., and Fisher, E.A. The
`full induction of human apoprotein A-I gene expression by the experimental
`nephrotic syndrome in transgenic mice depends on cis-acting elements in the
`proximal 256 base-pair promoter region and the trans-acting factor early growth
`response factor 1. J. Clin. Invest. 101:1699-1707, 1998.
`
`Fayad, Z.A., Fallon, J.T., Wehrli, S., Dansky, H., Poon, M., Badimon, J.,
`Charlton, S., Fisher, E.A., Breslow, J.L., and Fuster, V. Noninvasive in vivo
`high-resolution imaging of atherosclerotic lesions in genetically engineered mice.
`Circulation 98:1541-1547, 1998.
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`34.
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`35.
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`36.
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`37.
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`38.
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`39.
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`40.
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`41.
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`Zhou, M., Fisher E.A., and Ginsberg, H.N. Regulated co-translational
`ubiquitination of apolipoprotein B100. J. Biol. Chem. 273:24649-24653, 1998.
`
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`42. Mitchell, D.M., Zhou, M., Pariyarath, R., Wang, H., Aitchison, J., Ginsberg,
`H.N., and Fisher, E.A. Apoprotein B100 has a prolonged interaction with the
`translocon during which its lipidation and translocation change from dependence
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`on the microsomal triglyceride transfer protein to independence. Proc. Natl. Acad.
`Sci. USA 95:14733-14738, 1998.
`
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`43. Weng, W., Li, L., van Bennekum, A.M., Potter, S.H., Harrison, E.H., Blaner,
`W.S., Breslow, J.L., and Fisher, E.A. Intestinal absorption of dietary cholesteryl
`ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase
`knockout mice. Biochemistry 38:4143-4149,1999.
`
`Van Bennekum, A.M., Li, L., Piantedosi, R., Shamir, R., Vogel, S., Fisher, E.A.,
`Blaner, W.S., and Harrison, E.H. Carboxyl ester lipase overexpression in rat
`hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or
`metabolism of chylomicron-retinyl ester. Biochemistry 38:4150-4156, 1999.
`
`Van Bennekum, A.M., Fisher, E.A., Blaner, W.S., and Harrison, E.H. Hydrolysis
`of retinyl esters by pancreatic triglyceride lipase. Biochemistry 39:4900-4906,
`2000.
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`Pan, M., Liang, J., Fisher, E.A., and Ginsberg, H.N. Inhibition of translocation of
`nascent