throbber
7/16/22, 9:15 PM
`
`Symptoms and causes - Mayo Clinic
`
`
`
`
`
`
`Glaucoma
`
`Overview
`
`Glaucoma is a group of eye conditions that damage the optic nerve, the health of which is vital for
`good vision. This damage is often caused by an abnormally high pressure in your eye.
`
`Glaucoma is one of the leading causes of blindness for people over the age of 60. It can occur at any
`age but is more common in older adults.
`
`Many forms of glaucoma have no warning signs. The effect is so gradual that you may not notice a
`change in vision until the condition is at an advanced stage.
`
`Because vision loss due to glaucoma can't be recovered, it's important to have regular eye exams that
`include measurements of your eye pressure so a diagnosis can be made in its early stages and
`treated appropriately. If glaucoma is recognized early, vision loss can be slowed or prevented. If you
`have the condition, you'll generally need treatment for the rest of your life.
`Symptoms
`
`The signs and symptoms of glaucoma vary depending on the type and stage of your condition. For
`example
`Open-angle glaucoma
`
`Patchy blind spots in your side (peripheral) or central vision, frequently in both eyes
`
`Tunnel vision in the advanced stages
`
`Acute angle-closure glaucoma
`
`Severe headache
`Eye pain
`Nausea and vomiting
`Blurred vision
`Halos around lights
`Eye redness
`
`
`
`
`
`
`
`
`https://www.mayoclinic.org/diseases-conditions/glaucoma/symptoms-causes/syc-20372839?p=1
`
`Feedback
`
`1/4
`
`Eye Therapies Exhibit 2173, 1 of 4
`Slayback v. Eye Therapies - IPR2022-00142
`
`

`

`Symptoms and causes - Mayo Clinic
`7/16/22, 9:15 PM
`If left untreated, glaucoma will eventually cause blindness. Even with treatment, about 15 percent of
`people with glaucoma become blind in at least one eye within 20 years.
`When to see a doctor
`
`Promptly go to an emergency room or an eye doctor's (ophthalmologist's) office if you experience
`some of the symptoms of acute angle-closure glaucoma, such as severe headache, eye pain and
`blurred vision
`Causes
`
`Glaucoma is the result of damage to the optic nerve. As this nerve gradually deteriorates, blind spots
`develop in your visual field. For reasons that doctors don't fully understand, this nerve damage is
`usually related to increased pressure in the eye.
`
`Elevated eye pressure is due to a buildup of a fluid (aqueous humor) that flows throughout the inside of
`your eye. This internal fluid normally drains out through a tissue called the trabecular meshwork at the
`angle where the iris and cornea meet. When fluid is overproduced or the drainage system doesn't
`work properly, the fluid can't flow out at its normal rate and eye pressure increases.
`
`Glaucoma tends to run in families. In some people, scientists have identified genes related to high eye
`pressure and optic nerve damage.
`
`Types of glaucoma include:
`Open-angle glaucoma
`
`Open-angle glaucoma is the most common form of the disease. The drainage angle formed by the
`cornea and iris remains open, but the trabecular meshwork is partially blocked This causes pressure
`in the eye to gradually increase. This pressure damages the optic nerve. It happens so slowly that you
`may lose vision before you're even aware of a problem
`Angle-closure glaucoma
`
`Angle closure glaucoma, also called closed angle glaucoma, occurs when the iris bulges forward to
`narrow or block the drainage angle formed by the cornea and iris. As a result, fluid can't circulate
`through the eye and pressure increases Some people have narrow drainage angles, putting them at
`increased risk of angle-closure glaucoma.
`
`Angle closure glaucoma may occur suddenly (acute angle closure glaucoma) or gradually (chronic
`angle-closure glaucoma). Acute angle-closure glaucoma is a medical emergency.
`Normal-tension glaucoma
`
`In normal-tension glaucoma, your optic nerve becomes damaged even though your eye pressure is
`within the normal range. No one knows the exact reason for this. You may have a sensitive optic nerve,
`or you may have less blood being supplied to your optic nerve. This limited blood flow could be
`
`Feedback
`
`https://www.mayoclinic.org/diseases-conditions/glaucoma/symptoms-causes/syc-20372839?p=1
`
`2/4
`
`Eye Therapies Exhibit 2173, 2 of 4
`Slayback v. Eye Therapies - IPR2022-00142
`
`

`

`Symptoms and causes - Mayo Clinic
`7/16/22, 9:15 PM
`caused by atherosclerosis — the buildup of fatty deposits (plaque) in the arteries — or other
`conditions that impair circulation.
`Glaucoma in children
`
`It's possible for infants and children to have glaucoma It may be present from birth or develop in the
`first few years of life. The optic nerve damage may be caused by drainage blockages or an underlying
`medical condition
`Pigmentary glaucoma
`
`In pigmentary glaucoma, pigment granules from your iris build up in the drainage channels, slowing or
`blocking fluid exiting your eye. Activities such as jogging sometimes stir up the pigment granules,
`depositing them on the trabecular meshwork and causing intermittent pressure elevations
`Risk factors
`
`Because chronic forms of glaucoma can destroy vision before any signs or symptoms are apparent,
`be aware of these risk factors:
`
`
`
`
`
`
`
`Having high internal eye pressure (intraocular pressure)
`Being over age 60
`Being black, Asian or Hispanic
`Having a family history of glaucoma
`Having certain medical conditions, such as diabetes, heart disease, high blood pressure and
`sickle cell anemia
`Having corneas that are thin in the center
`
`Being extremely nearsighted or farsighted
`
`Having had an eye injury or certain types of eye surgery
`
`Taking corticosteroid medications, especially eyedrops, for a long time
`
`Prevention
`
`
`
`These self-care steps can help you detect glaucoma in its early stages, which is important in
`preventing vision loss or slowing its progress.
`Get regular dilated eye examinations. Regular comprehensive eye exams can help detect
`glaucoma in its early stages, before significant damage occurs. As a general rule, the American
`Academy of Ophthalmology recommends having a comprehensive eye exam every five to 10
`years if you're under 40 years old; every two to four years if you're 40 to 54 years old; every one to
`three years if you're 55 to 64 years old; and every one to two years if you're older than 65 If you're
`at risk of glaucoma, you'll need more frequent screening. Ask your doctor to recommend the right
`screening schedule for you
`
`Feedback
`
`https://www.mayoclinic.org/diseases-conditions/glaucoma/symptoms-causes/syc-20372839?p=1
`
`3/4
`
`Eye Therapies Exhibit 2173, 3 of 4
`Slayback v. Eye Therapies - IPR2022-00142
`
`

`

`7/16/22, 9:15 PM
`Symptoms and causes - Mayo Clinic
`Know your family's eye health history. Glaucoma tends to run in families. If you're at increased
`
`risk, you may need more frequent screening.
`Exercise safely. Regular, moderate exercise may help prevent glaucoma by reducing eye
`pressure. Talk with your doctor about an appropriate exercise program.
`Take prescribed eyedrops regularly. Glaucoma eyedrops can significantly reduce the risk that
`high eye pressure will progress to glaucoma. To be effective, eyedrops prescribed by your doctor
`need to be used regularly even if you have no symptoms.
`Wear eye protection. Serious eye injuries can lead to glaucoma. Wear eye protection when
`using power tools or playing high-speed racket sports in enclosed courts.
`
`
`
`
`
`
`
`By Mayo Clinic Staff
`
`Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
`
`Terms and Conditions
`Privacy Policy
`Notice of Privacy Practices
`Notice of Nondiscrimination
`
`Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does
`not endorse any of the third party products and services advertised.
`
`Advertising and sponsorship policy
`-
`Advertising and sponsorship opportunities
`
`A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic,"
`"MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation
`for Medical Education and Research.
`
`© 1998-2022 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved.
`
`https://www.mayoclinic.org/diseases-conditions/glaucoma/symptoms-causes/syc-20372839?p=1
`
`Feedback
`
`4/4
`
`Eye Therapies Exhibit 2173, 4 of 4
`Slayback v. Eye Therapies - IPR2022-00142
`
`

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket