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Eye Therapies Exhibit 2150, 1 of 5
`Slayback v. Eye Therapies - IPR2022-00142
`
`

`

`8/16/22, 12:14 PM
`
`Answer
`
`Lumify Vs. Visine: What Is The Difference?
`
`Lumify and Visine eye drops are both available over the counter to relieve red
`eyes. While Visine has been on the market for years, Lumify was just recently
`approved by the FDA in December of 2017. However, the active ingredient in
`Lumify, brimonidine, has been available in prescription products such
`Alphagan-P eye drops for some time. Below, we discuss the similarities and
`differences between Lumify and Visine.
`
`Active Ingredients
`
`The active ingredient in Visine is tetrahydrozoline.
`The active ingredient in Lumify is brimonidine.
`
`
`
`Both tetrahydrozoline and brimonidine are classified as α adrenergic
`2
`agonists. They work to reduce eye redness mainly by causing vasoconstriction
`of the blood vessels in the eye. This creates temporary relief from tissue
`congestion, which is why Visine and Lumify are sometimes classified as ocular
`decongestants. They may also work by lowering the production of
`norepinephrine, which decreases blood flow.
`
`Between tetrahydrozoline (Visine) and brimonidine (Lumify), brimonidine is
`considered a "second generation α adrenergic agonist" and is more selective
`2
`for adrenergic receptors. The clinical significance of this is not well known
`but, brimonidine (Lumify) is thought to have fewer side effects
`than tetrahydrozoline including a lower risk of rebound redness or tolerance,
`also known as tachyphylaxis, a common problem with eye decongestants.
`
`Dosing
`
`The dosing for Visine and Lumify are similar. Both are labeled to be used up
`to four times daily. However, brimonidine (Lumify) is thought to last longer
`per dose than tetrahydrozoline (Visine). Each dose of Lumify should last
`between 6 to 8 hours while each dose of Visine should last between 4 and 6
`
`https://walrus.com/questions/lumify-vs-visine-what-is-the-difference
`
`2/5
`
`Eye Therapies Exhibit 2150, 2 of 5
`Slayback v. Eye Therapies - IPR2022-00142
`
`

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`Eye Therapies Exhibit 2150, 3 of 5
`Slayback v. Eye Therapies - IPR2022-00142
`
`

`

`Eye Therapies Exhibit 2150, 4 of 5
`Slayback v. Eye Therapies - IPR2022-00142
`
`

`

`8/16/22, 12:14 PM
`© 2022 Walus Health
`
`Lumify Vs. Visine: What Is The Difference?
`
`https://walrus.com/questions/lumify-vs-visine-what-is-the-difference
`
`5/5
`
`Eye Therapies Exhibit 2150, 5 of 5
`Slayback v. Eye Therapies - IPR2022-00142
`
`

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