Filed on behalf of: Sarepta Therapeutics, Inc.
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`Filed: June 21, 2021
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`UNITED STATES PATENT AND TRADEMARK OFFICE
`______________________
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`______________________
`
`SAREPTA THERAPEUTICS, INC.
`Petitioner
`v.
`NIPPON SHINYAKU CO., LTD.
`&
`NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY
`Patent Owners
`______________________
`
`Case No. IPR2021-01134
`Patent No. 9,708,361
`______________________
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`I, Kelley M. Hayes Greenhill, being of full age and duly sworn, state as
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`
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`follows:
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`
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`I have prepared this Declaration in connection with the Petition of
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`Sarepta Therapeutics, Inc. (“Sarepta”), for inter partes review of U.S. Patent No.
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`9,708,361 (“the ’361 patent”), which I understand will be filed concurrently with
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`this Declaration.
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`I am currently a Manager, Research and Information Services at
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`Finnegan, Henderson, Farabow, Garrett & Dunner, LLP, 901 New York Ave, NW,
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`Washington, DC 20001-4413.
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`
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`I am over eighteen years of age and am competent to make this
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`Declaration. I make this Declaration based on my own personal knowledge and
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`based on my knowledge of library science practices.
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`
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`I earned a Master of Science in Library Science from the Catholic
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`University of America in 1995, and a Bachelor of Arts in Political Science from
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`Duquesne University in 1989. I have worked as a librarian for over twenty-five
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`years. I have been employed in the Research & Information Services Department at
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`Finnegan Henderson since 2019. Before that, from 1995-2015, I was employed in
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`the Library Department of Sterne Kessler Goldstein & Fox. And from 2015-2019, I
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`was employed in the Knowledge and Research Service Group (formerly,
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`Information Research Service) at Northrop Grumman Corporation.
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`2
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`I am currently a member of the American Association of Law Libraries.
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`Summary of Opinions
`In view of the foregoing, it is my opinion that the publications described
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`below were publicly available on or about the corresponding date listed in the
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`following table:
`
`Exhibit
`1021
`
`1022
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`
`
`Publication
`Popplewell et al., “Comparative
`Analysis of Antisense
`Oligonucleotide Sequences
`Targeting Exon 53 of the Human
`DMD Gene: Implications for Future
`Clinical Trials,” Neuromuscul.
`Disord. (2010) 20:102-110
`Sazani et al., “Safety Pharmacology
`and Genotoxicity Evaluation of
`AVI-4658,” Int. J. Toxicol. (2010)
`29(2):143-156
`
`Publicly Available on
`or About
`February 1, 2010
`
`March 1, 2010
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`
`
`Standard Library Practices
`I have knowledge of and experience with standard library practices
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`regarding receipt, cataloging, and shelving of materials. For example, I have
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`knowledge of and experience with the Machine-Readable Cataloging (“MARC”)
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`system that libraries use to catalog materials.
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`Based on standard library practice, when a library receives an item, it
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`stamps the item with the library name and often with a date that is within a few days
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`or weeks of receipt. The library will catalog the item within a matter of a few days
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`or weeks of receiving it.
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`
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`By the mid-1970s, standard library practice involved cataloguing items
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`using the MARC system. The MARC system was developed in the 1960s to
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`standardize bibliographic records so they could be read by computers and shared
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`among libraries. By the mid-1970s, MARC had become the international standard
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`for bibliographic data, and it is still used today.
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` After an item is cataloged, standard library practice is to then shelve the
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`item within a matter of a few days or weeks of cataloging it.
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` Taking into account the few days or weeks between receiving an item
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`and cataloging it, and the few days or weeks between cataloging an item and shelving
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`it, the total time between receiving an item and shelving it ranges from a couple of
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`weeks to a few months. The public can access an item after it is cataloged by
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`searching the catalog and requesting the item from the library.
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` MARC Records
` Many libraries provide public access to their MARC records via the
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`Internet and/or their electronic cataloguing system at the library. In a MARC record,
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`each field provides information about the cataloged item. MARC uses a simple
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`three-digit numeric code (from 001-999) to identify each field in the record. For
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`example, field 245 lists the title of the work and field 260 lists publisher information.
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`Field 060 represents the National Library of Medicine Call Number. Field 060
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`includes two indicators and several subfield codes. The first indicator provides
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`information on whether the item at issue exists in the National Library of Medicine
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`collection (blank = no information provided; 0 = item in the Library; 1 = item not in
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`the Library). A subfield code starting with “$b” identifies a specific item number
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`unique to the item (“Call” number).
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` Libraries can create MARC records for various types of publications,
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`including serial publications such as scientific journals. Serial publications are
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`publications that have the same collective title but are published in a succession of
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`discrete parts (e.g., volumes and issues), typically at regular intervals. MARC
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`records for serial publications represent the entire run of the title. If a publication is
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`a periodical, then its publication frequency is recorded in Field 310, and the
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`publication dates (e.g., the first and last publication) are recorded in Field 362. With
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`knowledge of the first issue or volume published, future issues or volumes can be
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`predicted based on the information provided in the MARC record. Field 510
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`identifies databases in which the publication has been indexed (e.g., PubMed).
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` Attached as Exhibit A are explanations from the Library of Congress
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`of the MARC records and fields.
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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` Exhibit 1021 (“Popplewell”)
` Exhibit 1021, submitted with Sarepta’s petition for inter partes review,
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`is a true and correct copy of an article contained in the February 2010 issue of
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`Neuromuscular Disorders (Volume 20, Issue 2). Exhibit 1021 includes an article
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`entitled “Comparative analysis of antisense oligonucleotide sequences targeting
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`exon 53 of the human DMD gene: Implications for future clinical trials” by Linda J.
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`Popplewell, Cal Adkin, Virginia Arechavala-Gomeza, Annemieke Aartsma-Rus,
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`Christa L. de Winter, Steve D. Wilton, Jennifer E. Morgan, Francesco Muntoni, Ian
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`R. Graham, and George Dickson (“Popplewell”), which appears on pages 102–110
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`of the issue. I obtained a copy of Exhibit 1021 from the National Library of
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`Medicine in a condition that creates no suspicion about its authenticity. The text of
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`Popplewell appears to be complete: no pages are missing, the text on each page
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`appears to flow from one page to the next, and there are no visible alterations to the
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`document.
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` As shown on the first page of Exhibit 1021, the front page of the
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`February 2010 issue of Neuromuscular Disorders has two stamps, indicating that
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`this issue was collected as part of the “General Collection” of the National Library
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`of Medicine:
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`I also reviewed MARC records, which corroborate that the National
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`Library of Medicine received the February 2010 issue of Neuromuscular Disorders
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`that contains Exhibit 1021. Attached as Exhibit B to this Declaration is a copy of
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`the MARC records for Neuromuscular Disorders at the National Library of
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`Medicine. According to field 060 of the MARC records attached as Exhibit B, the
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`Call number designated for the February 2010 issue is “NE337GB,” the same Call
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`number shown in one of the stamps on the first page of Exhibit 1021. Field 060
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`further indicates that the item continues to be available in the Library. See field 060
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`entry in Exhibit B (first indicator being 0). In addition, according to the field 362 of
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`the MARC records attached as Exhibit B, the National Library of Medicine has
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`received Neuromuscular Disorders since its very first issue (“Vol. 1, no. 1-”) and
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`continues to receive issues of the publication.
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` Field 510 of the MARC records in Exhibit B further indicates that
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`Neuromuscular Disorders was included in several well-known indices, including
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`MEDLINE, PubMed, and Index Medicus. See field 510 entries in Exhibit B. I also
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`located the PubMed record for Ex. 1021, which further confirms that Ex. 1021 was
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`included in the PubMed index before August 31, 2011. See Exhibit C; see also
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`Exhibit D (PubMed Data Element (Field) Descriptions). Field “EDAT” (Entrez
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`Date), which refers to the date the citation was added to PubMed, indicates that the
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`citation of Ex. 1021 was added to PubMed on January 19, 2010. See field EDAT
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`entry in Exhibit C. Field “SO” (Source), which provides additional dates such as an
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`electronic publication date (“Epub”), indicates that Ex. 1021 was electronically
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`published on January 15, 2010. See field SO entry in Exhibit C. Consistent with the
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`information in the MARC/PubMed records of Ex. 1021, the publisher’s website
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`indicates that the print issue containing Popplewell was published on February 1,
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`20101.
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` Based on the fact that a print copy of Exhibit 1021 can be found in the
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`National Library of Medicine, supported by the corresponding MARC/PubMed
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`records attached as Exhibits B and C, it is my opinion that Popplewell’s serial title
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`had been received, cataloged, and indexed at the National Library of Medicine and
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`made part of its online catalog database on or shortly after February 1, 2010, and
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`became available to the public on or shortly after that date. On or shortly after
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`February 1, 2010, any member of the public could have located Popplewell by
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`1 https://www.nmd-journal.com/article/S0960-8966(09)00666-X/fulltext#%20 (last
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`visited June 15, 2021).
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`searching through the National Library of Medicine’s catalog by subject matter,
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`author, or title. Similarly, interested researchers in the field would have been able
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`to locate Popplewell on or shortly after February 1, 2010 via several well-known
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`indices such as MEDLINE, PubMed, and Index Medicus by searching subject
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`matter, author, or title. As such, Popplewell would have been available to the public
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`before August 31, 2011.
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` Not only was Popplewell accessible and available to researchers in the
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`field as of August 2011, researchers did access and rely on this article in their works,
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`further confirming its availability and accessibility. For example, Google Scholar,
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`which is included as Exhibit E to this Declaration, indicates that Popplewell had
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`been cited 96 times as of June 11, 2021, including being cited prior to August 31,
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`2011. One such example is an article entitled “Gene therapy for muscle disease,” in
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`the journal Experimental Cell Research, authored by Yuko Miyagoe-Suzuki and
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`Shin’ichi Takeda, a copy of which is attached as Exhibit F to this Declaration. I
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`understand that Shin’ichi Takeda is one of the named authors of the ’361 patent. As
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`shown in Exhibit F, Popplewell is cited as Ref. #34 in this article. See Exhibit F,
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`3091. According to the website for the journal Experimental Cell Research, Exhibit
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`F became available online in May 2010.2 The fact that an article published before
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`August 31, 2011 cited Popplewell further supports that Popplewell was available to
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`the public before August 31, 2011.
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` Exhibit 1022 (“Sazani”)
` Exhibit 1022, submitted with Sarepta’s petition for inter partes review,
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`is a true and correct copy of an article contained in the March/April 2010 issue of
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`International Journal of Toxicology (Volume 29, Number 2). Exhibit 1022 includes
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`an article entitled “Safety Pharmacology and Genotoxicity Evaluation of AVI-4658”
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`by Peter Sazani, Doreen L. Weller, and Stephen B. Shrewsbury (“Sazani”), which
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`appears on pages 143–156 of the issue. I obtained a copy of Exhibit 1022 from the
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`National Library of Medicine in a condition that creates no suspicion about its
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`authenticity. The text of Sazani appears to be complete: no pages are missing, the
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`text on each page appears to flow from one page to the next, and there are no visible
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`alterations to the document.
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` As shown on the first page of Exhibit 1022, the front page of the
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`March/April 2010 issue of Neuromuscular Disorders has a stamp indicating that this
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`2 https://www.sciencedirect.com/science/article/abs/pii/S0014482710002855 (last
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`visited June 15, 2021).
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`issue was collected as part of the “General Collection” of the National Library of
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`U.S. Patent No. 9,708,361
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`Medicine:
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`I also reviewed MARC records which corroborate that the National
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`Library of Medicine received the March/April 2010 issue of International Journal
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`of Toxicology that contains Exhibit 1022. Attached as Exhibit G to this Declaration
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`is a copy of the MARC records for International Journal of Toxicology at the
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`National Library of Medicine. According to field 060 of the MARC records attached
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`as Exhibit G, the Call number designated for the March/April 2010 issue is
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`“JO908V,” the same Call number shown in one of the stamps on the first page of
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`Exhibit 1022. Field 060 further indicates that the item continues to be available in
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`the Library. See field 060 entry in Exhibit G (first indicator being 0). In addition,
`
`according to the field 362 of the MARC records attached as Exhibit G, the National
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`Library of Medicine has received International Journal of Toxicology since the
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`January/February 1997 issue (“Vol. 16, no. 1 (Jan.-Feb. 1997)”) and continues to
`
`receive the publication.
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` Field 510 of the MARC records in Exhibit G further indicates that the
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`International Journal of Toxicology was included in several well-known indices,
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`including MEDLINE, PubMed, and Index Medicus. See field 510 entries in Exhibit
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`G. I also located the PubMed record for Ex. 1022, which further confirms that Ex.
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`1022 was included in the PubMed index before August 31, 2011. See Exhibit H; see
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`also Exhibit D (PubMed Data Element (Field) Descriptions). Field “EDAT” (Entrez
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`Date), which refers to the date the citation was added to PubMed, indicates that the
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`citation of Ex. 1022 was added to PubMed on January 30, 2010. See field EDAT
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`entry in Exhibit C. Field “SO” (Source), which provides additional dates such as an
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`electronic publication date (“Epub”), indicates that Ex. 1022 was electronically
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`published on January 28, 2010. See field SO entry in Exhibit C. Consistent with the
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`information in the MARC/PubMed records of Ex. 1022, the publisher’s website
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`indicates that Sazani was first published online on January 28, 2010 and the print
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`issue containing Sazani was published on March 1, 20103.
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` Based on the fact that a print copy of Exhibit 1022 can be found in the
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`National Library of Medicine, supported by the corresponding MARC/PubMed
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`records attached as Exhibits G and H, it is my opinion that Sazani’s serial title had
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`been received, cataloged, and indexed at the National Library of Medicine and made
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`part of its online catalog database on or shortly after March 1, 2010, and became
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`3 https://journals.sagepub.com/doi/10.1177/1091581809359206 (last visited June
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`15, 2021).
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`available to the public on or shortly after that date. On or shortly after March 1,
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`
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`2010, any member of the public could have located Sazani by searching through the
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`National Library of Medicine’s catalog by subject matter, author, or title. Similarly,
`
`interested researchers in the field would have been able to locate Sazani on or shortly
`
`after March 1, 2010 via several well-known indices such as MEDLINE, PubMed,
`
`and Index Medicus by searching subject matter, author, or title. As such, Sazani
`
`would have been available to the public before August 31, 2011.
`
` Not only was Sazani accessible and available to researchers in the field
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`as of August 2011, researchers did access and rely on this article in their works,
`
`further confirming its availability and accessibility. For example, Google Scholar,
`
`which is included as Exhibit I to this Declaration, indicates that Sazani had been
`
`cited 48 times as of June 11, 2021, including being cited prior to August 31, 2011.
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`One such example is an article entitled “Restoring Dystrophin Expression in
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`Duchenne Muscular Dystrophy Muscle: Progress in Exon Skipping and Stop Codon
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`Read Through,” in the journal American Journal of Pathology, authored by Eric P.
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`Hoffman, Abby Bronson, Arthur A. Levin, Shin’ichi Takeda, Toshifumi Yokota,
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`Andreas R. Baudy, and Edward M. Connor, a copy of which is attached as Exhibit
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`H to this Declaration. As noted earlier, I understand that Shin’ichi Takeda is one of
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`the named authors of the ’361 patent. As shown in Exhibit J, Sazani is cited as Ref.
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`#38 in this article. See Exhibit J, 21. According to the website for the journal
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`13
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`Case No. IPR2021-01134
`U.S. Patent No. 9,708,361
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`American Journal of Pathology, Exhibit J became available online in May 2011.4
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`The fact that an article published before August 31, 2011 cited Sazani further
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`supports that Sazani was available to the public before August 31 , 2011.
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`VI. Conclusion
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`27.
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`I declare that all statements made herein of my knowledge are true, and
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`that all statements made on information and belief are believed to be true. I further
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`declare that all statements made herein were made with the knowledge that willful
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`false statements and the like are punishable by fine or imprisonment or both, under
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`Section 1001 of Title 18 of the United States Code.
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`28.
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`In signing this declaration, I understand that the declaration will be filed
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`as evidence in a contested case before the Patent Trial and Appeal Board of the
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`United States Patent and Trademark Office. I acknowledge that I may be subject to
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`cross examination in the case and that cross examination will take place within the
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`United States. If cross examination is required of me, I will appear for cross
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`examination within the United States during the time allotted for cross examination.
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`Date: June 17, 2021
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`By: ~ - - - - - - - - - - - -
`
`Kelley M. Hayes Greenhill
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`4 https://ajp.amjpathol.org/article/S0002-9440( 11)0037 5-0/fulltext (last visited
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`June 15, 2021).
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`EXHIBIT A
`EXHIBIT A
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`Sarepta Exhibit 1089, Page 15 of 190
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`MARC 21 Format for Bibliographic Data: Table of Contents (Network Development and MARC Standards Office, Library of Congress)
`Library of Congress >> MARC >> Bibliographic Field List
`
`MARC 21 Format for Bibliographic Data
`Field List
`
`1999 Edition
`Update No. 1 (October 2000) through Update No. 30 (May 2020)
`
`This document lists all valid and obsolete data elements that may appear in MARC 21
`bibliographic records. It is intended to meet the need for a simple data element list to support
`MARC system development and online validation of MARC data elements. This listing does
`not include any descriptions or examples of MARC data elements. Descriptions and
`examples can be found in the MARC 21 Format for Bibliographic Data.
`
`--Leader and Directory--
` LEADER
` Character Positions
` 00-04 - Logical record length
` 05 - Record status
` a - Increase in encoding level
` c - Corrected or revised
` d - Deleted
` n - New
` p - Increase in encoding level from prepublication
` 06 - Type of record
` a - Language material
` b - Archival and manuscripts control [OBSOLETE]
` c - Notated music
` d - Manuscript notated music
` e - Cartographic material
` f - Manuscript cartographic material
` g - Projected medium
` h - Microform publications [OBSOLETE]
` i - Nonmusical sound recording
` j - Musical sound recording
` k - Two-dimensional nonprojectable graphic
` m - Computer file
` n - Special instructional material [OBSOLETE]
` o - Kit
` p - Mixed material
` r - Three-dimensional artifact or naturally occurring object
` t - Manuscript language material
` 07 - Bibliographic level
` a - Monographic component part
` b - Serial component part
` c - Collection
` d - Subunit
` i - Integrating resource
` m - Monograph/item
` s - Serial
` 08 - Type of control
` # - No specific type
` a - Archival
` 09 - Character coding scheme
` # - MARC-8
` a - UCS/Unicode
` 10 - Indicator count
` 11 - Subfield code count
` 12-16 - Base address of data
` 17 - Encoding level
`
`https://www.loc.gov/marc/bibliographic/ecbdlist.html
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`MARC 21 Format for Bibliographic Data: Table of Contents (Network Development and MARC Standards Office, Library of Congress)
` # - Full level
` 1 - Full level, material not examined
` 2 - Less-than-full level, material not examined
` 3 - Abbreviated level
` 4 - Core level
` 5 - Partial (preliminary) level
` 7 - Minimal level
` 8 - Prepublication level
` u - Unknown
` z - Not applicable
` 18 - Descriptive cataloging form
` # - Non-ISBD
` a - AACR 2
` c - ISBD punctuation omitted
` i - ISBD punctuation included
` n - Non-ISBD punctuation omitted
` p - Partial ISBD (BK) [OBSOLETE]
` r - Provisional (VM MP MU) [OBSOLETE]
` u - Unknown
` 19 - Multipart resource record level
` # - Not specified or not applicable
` a - Set
` b - Part with independent title
` c - Part with dependent title
` 20-23 - Entry map
` 20 - Length of the length-of-field portion
` 21 - Length of the starting-character-position portion
` 22 - Length of the implementation-defined portion
` 23 - Undefined Entry map character position
`
` DIRECTORY
` Character Positions
` 00-02 - Tag
` 03-06 - Field length
` 07-11 - Starting character position
`
`
`--Control Fields (001-006)--
`001 - CONTROL NUMBER (NR)
`
`003 - CONTROL NUMBER IDENTIFIER (NR)
`
`005 - DATE AND TIME OF LATEST TRANSACTION (NR)
`
`006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION (R)
` 006--BOOKS
` Character Positions
` 00 - Form of material
` a - Language material
` t - Manuscript language material
` 01-04 - Illustrations
` 05 - Target audience
` 06 - Form of item
` 07-10 - Nature of contents
` 11 - Government publication
` 12 - Conference publication
` 13 - Festschrift
` 14 - Index
` 15 - Undefined
` 16 - Literary form
` 17 - Biography
` 006--COMPUTER FILES/ELECTRONIC RESOURCES
` Character Positions
` 00 - Form of material
` m - Computer file/Electronic resource
` 01-04 - Undefined
` 05 - Target audience
`https://www.loc.gov/marc/bibliographic/ecbdlist.html
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`MARC 21 Format for Bibliographic Data: Table of Contents (Network Development and MARC Standards Office, Library of Congress)
` 06 - Form of item
` 07-08 - Undefined
` 09 - Type of computer file
` 10 - Undefined
` 11 - Government publication
` 12-17 - Undefined
` 006--MAPS
` Character Positions
` 00 - Form of material
` e - Cartographic material
` f - Manuscript cartographic material
` 01-04 - Relief
` 05-06 - Projection
` 07 - Undefined
` 07 - Prime meridian [OBSOLETE]
` 08 - Type of cartographic material
` 09-10 - Undefined
` 11 - Government publication
` 12 - Form of item
` 12 - Undefined [OBSOLETE]
` 13 - Undefined
` 14 - Index
` 15 - Undefined
` 16-17 - Special format characteristics
` 006--MIXED MATERIALS
` Character Positions
` 00 - Form of material
` p - Mixed material
` 01-05 - Undefined
` 06 - Form of item
` 07-17 - Undefined
` 006--MUSIC
` Character Positions
` 00 - Form of material
` c - Notated music
` d - Manuscript notated music
` i - Nonmusical sound recording
` j - Musical sound recording
` 01-02 - Form of composition
` 03 - Format of music
` 04 - Music parts
` 05 - Target audience
` 06 - Form of item
` 07-12 - Accompanying matter
` 13-14 - Literary text for sound recordings
` 15 - Undefined
` 16 - Transposition and arrangement
` 17 - Undefined
` 006--CONTINUING RESOURCES
` Character Positions
` 00 - Form of material
` s - Serial/Integrating resource
` 01 - Frequency
` 02 - Regularity
` 03 - ISSN Center [OBSOLETE]
` 04 - Type of continuing resource
` 05 - Form of original item
` 06 - Form of item
` 07 - Nature of entire work
` 08-10 - Nature of contents
` 11 - Government publication
` 12 - Conference publication
` 13-15 - Undefined
` 16 - Original alphabet or script of title
` 17 - Entry convention
` 006--VISUAL MATERIALS
` Character Positions
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`MARC 21 Format for Bibliographic Data: Table of Contents (Network Development and MARC Standards Office, Library of Congress)
` 00 - Form of material
` g - Projected medium
` k - Two-dimensional nonprojectable graphic
` o - Kit
` r - Three-dimensional artifact or naturally occurring object
` 01-03 - Running time
` 04 - Undefined
` 05 - Target audience
` 06-10 - Undefined
` 06-10 - Accompanying matter [OBSOLETE]
` 11 - Government publication
` 12 - Form of item
` 12 - Undefined [OBSOLETE]
` 13-15 - Undefined
` 16 - Type of visual material
` 17 - Technique
`
`
`--Control Field 007--
`007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION (R)
` 007--MAP
` Character Positions
` 00 - Category of material
` a - Map
` 01 - Specific material designation
` d - Atlas
` g - Diagram
` j - Map
` k - Profile
` q - Model
` r - Remote-sensing image
` s - Section
` u - Unspecified
` y - View
` z - Other
` | - No attempt to code
` 02 - Undefined
` 03 - Color
` a - One color
` c - Multicolored
` | - No attempt to code
` 04 - Physical medium
` a - Paper
` b - Wood
` c - Stone
` d - Metal
` e - Synthetic
` f - Skin
` g - Textile
` i - Plastic
` j - Glass
` l - Vinyl
` n - Vellum
` p - Plaster
` q - Flexible base photographic, positive
` r - Flexible base photographic, negative
` s - Non-flexible base photographic, positive
` t - Non-flexible base photographic, negative
` u - Unknown
` v - Leather
` w - Parchment
` x - Not applicable
` y - Other photographic medium
` z - Other
` | - No attempt to code
` 05 - Type of reproduction
` f - Facsimile
` n - Not applicable
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` u - Unknown
` z - Other
` | - No attempt to code
` 06 - Production/reproduction details
` a - Photocopy, blueline print
` b - Photocopy
` c - Photographic pre-production
` d - Film
` u - Unknown
` z - Other
` | - No attempt to code
` 07 - Positive/negative aspect
` a - Positive
` b - Negative
` m - Mixed polarity
` n - Not applicable
` | - No attempt to code
` 007--ELECTRONIC RESOURCE
` Character Positions
` 00 - Category of material
` c - Computer file
` 01 - Specific material designation
` a - Tape cartridge
` b - Chip cartridge
` c - Computer optical disc cartridge
` d - Computer disc, type unspecified
` e - Computer disc cartridge, type unspecified
` f - Tape cassette
` h - Tape reel
` j - Magnetic disk
` k - Computer card
` m - Magneto-optical disc
` o - Optical disc
` r - Remote
` s - Standalone device
` u - Unspecified
` z - Other
` | - No attempt to code
` 02 - Undefined
` 03 - Color
` a - One color
` b - Black-and-white
` c - Multicolored
` g - Gray scale
` m - Mixed
` n - Not applicable
` u - Unknown
` z - Other
` | - No attempt to code
` 04 - Dimensions
` a - 3 1/2 in.
` e - 12 in.
` g - 4 3/4 in. or 12 cm.
` i - 1 1/8 x 2 3/8 in.
` j - 3 7/8 x 2 1/2 in.
` n - Not applicable
` o - 5 1/4 in.
` u - Unknown
` v - 8 in.
` z - Other
` | - No attempt to code
` 05 - Sound
` # - No sound (silent)
` a - Sound on medium
` u - Unknown
` | - No attempt to code
` 06-08 - Image bit depth
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`MARC 21 Format for Bibliographic Data: Table of Contents (Network Development and MARC Standards Office, Library of Congress)
` 001-999 - Exact bit depth
` mmm - Multiple
` nnn - Not applicable
` --- - Unknown
` ||| - No attempt to code
` 09 - File formats
` a - One
` m - Multiple
` u - Unknown
` | - No attempt to code
` 10 - Quality assurance target(s)
` a - Absent
` n - Not applicable
` p - Present
` u - Unknown
` | - No attempt to code
` 11 - Antecedent/source
` a - File reproduced from original
` b - File reproduced from microform
` c - File reproduced from an electronic resource
` d - File reproduced from an intermediate (not microform)
` m - Mixed
` n - Not applicable
` u - Unknown
` | - No attempt to code
` 12 - Level of compression
` a - Uncompressed
` b - Lossless
` d - Lossy
` m - Mixed
` u - Unknown
` | - No attempt to code
` 13 - Reformatting quality
` a - Access
` n - Not applicable
` p - Preservation
` r - Replacement
` u - Unknown
` | - No attempt to code
` 007--GLOBE
` Character Positions
` 00 - Category of material
` d - Globe
` 01 - Specific material designation
` a - Celestial globe
` b - Planetary or lunar globe
` c - Terrestrial globe
` e - Earth moon globe
` u - Unspecified
` z - Other
` | - No attempt to code
` 02 - Undefined
` 03 - Color
` a - One color
` c - Multicolored
` | - No attempt to code
` 04 - Physical medium
` a - Paper
` b - Wood
` c - Stone
` d - Metal
` e - Synthetic
` f - Skin
` g - Textile
` i - Plastic
` l - Vinyl
` n - Vellum
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` p - Plaster
` u - Unknown
` v - Leather
` w - Parchment
` z - Other
` | - No attempt to code
` 05 - Type of reproduction
` f - Facsimile
` n - Not applicable
` u - Unknown
` z - Other
` | - No attempt to code
` 007--TACTILE MATERIAL
` Chara