UNDERSTANDING THE SYMPTOMS
`
`DIABETIC RETINOPATHY
`
`DME
`
`WET AMD
`
`MEfRVO
`
`FINANCIAL SUPPORT
`
`HELPFUL RESOURCES
`
`Official EYLEA® (aflibercept) Injection Website
`
`Search
`Important: Help to manage your eye health during the COVID-19
`pandemic. Learn more >
`
`Your eyes have more
`they want to see.
`
`Discover how EYLEA may be able to help you fight back against certain retinal diseases.
`
`EYLEA is the #1 prescribed treatment in its class FDA-approved for Wet AMD, DME, and
`MEfRVO.*
`
`*
`
`IBM Truven MarketScan data: Number of injections administered, from Q4 2018 through Q3
`2019; Data on File.
`
`Learn about the common symptoms
`
`Prescribing Information
`For Healthcare Professionals
`
`IMPORTANT SAFETY INFORMATION
`
`®
`EYLEA (aflibercept) Injection is a prescription medicine administered by injection into the eye. You
`should not use EYLEA if you have an infection in or around the eye, eye pain or redness, or known
`allergies to any of the ingredients in EYLEA, including aflibercept.
`
`Find an Eye Doctor
`
`Diabetic Retinopathy (DR)
`
`Diabetic Retinopathy happens when too much blood sugar (glucose) damages the blood vessels in the retina.
`
`See an overview of DR
`
`https://eylea.us
`
`1/5
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`Mylan v. Regeneron, IPR2021-00881
`Page 1
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`

`Official EYLEA® (aflibercept) Injection Website
`
`Search
`
`UNDERSTANDING THE SYMPTOMS
`
`DIABETIC RETINOPATHY
`
`DME
`
`WET AMD
`
`MEfRVO
`
`FINANCIAL SUPPORT
`
`HELPFUL RESOURCES
`
`DME
`
`Diabetic Macular Edema is a complication of DR. In DME, the macula swells with fluid leaked from damaged blood
`vessels in the retina.
`
`See an overview of DME
`
`Prescribing Information
`For Healthcare Professionals
`
`Find an Eye Doctor
`
`Wet AMD
`
`IMPORTANT SAFETY INFORMATION
`
`Wet Age-related Macular Degeneration occurs when abnormal blood vessels grow under the macula while also
`leaking blood and fluid. This damages and scars the macula.
`®
`EYLEA (aflibercept) Injection is a prescription medicine administered by injection into the eye. You
`should not use EYLEA if you have an infection in or around the eye, eye pain or redness, or known
`allergies to any of the ingredients in EYLEA, including aflibercept.
`See an overview of Wet AMD
`
`https://eylea.us
`
`2/5
`
`MEfRVO
`
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`Mylan v. Regeneron, IPR2021-00881
`Page 2
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`

`

`Official EYLEA® (aflibercept) Injection Website
`Macular Edema following Retinal Vein Occlusion (MEfRVO) occurs when a blood vessel in the retina becomes blocked
`Search
`by a blood clot and leaks fluid into the macula. Vision loss or blurring happens as the macula swells with the fluid.
`
`See an overview of MEfRVO
`
`UNDERSTANDING THE SYMPTOMS
`
`DIABETIC RETINOPATHY
`
`DME
`
`WET AMD
`
`MEfRVO
`
`FINANCIAL SUPPORT
`
`HELPFUL RESOURCES
`
`No more waiting.
`Help your eyes fight back.
`
`Discussing what you’re going through is an important step to take with your eye care specialist.
`Whether you’ve been diagnosed or are experiencing these symptoms for the first time,
`download the appropriate discussion guide to see a list of helpful questions you can ask.
`
`Doctor Discussion Guide – First Visit
`105 KB
`
`Doctor Discussion Guide – Follow up Visits
`153 KB
`
`Find an Eye Doctor
`
`Find an eye doctor
`
`Prescribing Information
`For Healthcare Professionals
`
`IMPORTANT SAFETY INFORMATION
`
`®
`EYLEA (aflibercept) Injection is a prescription medicine administered by injection into the eye. You
`should not use EYLEA if you have an infection in or around the eye, eye pain or redness, or known
`allergies to any of the ingredients in EYLEA, including aflibercept.
`
`GET SUPPORT WITH EYLEA.
`
`Whether you're experiencing symptoms for the first time, or are already an EYLEA
`patient, we have support and resources here for you.
`
`https://eylea.us
`
`3/5
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`Mylan v. Regeneron, IPR2021-00881
`Page 3
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`Official EYLEA® (aflibercept) Injection Website
`Check out our helpful low vision tips, our resources for caregivers, and our
`Search
`comprehensive support program available to help eligible patients with the cost of
`EYLEA.
`
`See our helpful resources
`
`UNDERSTANDING THE SYMPTOMS
`
`DIABETIC RETINOPATHY
`
`DME
`
`WET AMD
`
`MEfRVO
`
`FINANCIAL SUPPORT
`
`HELPFUL RESOURCES
`
`SIGN UP FOR MORE INFORMATION
`
`Get the latest materials and communications about EYLEA—and a
`complimentary pocket magnifier, too.
`
`Sign up
`
`FINANCIAL SUPPORT FROM EYLEA4U®
`
`Find an Eye Doctor
`
`Prescribing Information
`For Healthcare Professionals
`
`IMPORTANT SAFETY INFORMATION
`
`EYLEA4U is a comprehensive support program with several resources
`®
`EYLEA (aflibercept) Injection is a prescription medicine administered by injection into the eye. You
`available to help eligible patients with the cost of EYLEA.
`should not use EYLEA if you have an infection in or around the eye, eye pain or redness, or known
`allergies to any of the ingredients in EYLEA, including aflibercept.
`
`Find out more
`
`IMPORTANT SAFETY INFORMATION
`
`EYLEA® (aflibercept) Injection is a prescription medicine administered by injection into
`the eye. You should not use EYLEA if you have an infection in or around the eye, eye pain
`or redness, or known allergies to any of the ingredients in EYLEA, including aflibercept.
`
`Injections into the eye with EYLEA can result in an infection in the eye and retinal
`detachment (separation of retina from back of the eye) can occur. Inflammation in the
`eye has been reported with the use of EYLEA.
`
`In some patients, injections with EYLEA may cause a temporary increase in eye pressure
`within 1 hour of the injection. Sustained increases in eye pressure have been reported
`with repeated injections, and your doctor may monitor this after each injection.
`
`https://eylea.us
`
`4/5
`
`Mylan Exhibit 1171
`Mylan v. Regeneron, IPR2021-00881
`Page 4
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`

`

`UNDERSTANDING THE SYMPTOMS
`
`DIABETIC RETINOPATHY
`
`DME
`
`WET AMD
`
`MEfRVO
`
`FINANCIAL SUPPORT
`
`HELPFUL RESOURCES
`
`Official EYLEA® (aflibercept) Injection Website
`There is a potential but rare risk of serious and sometimes fatal side effects, related to
`Search
`blood clots, leading to heart attack or stroke in patients receiving EYLEA.
`
`The most common side effects reported in patients receiving EYLEA were increased
`redness in the eye, eye pain, cataract, vitreous (gel-like substance) detachment, vitreous
`floaters, moving spots in the field of vision, and increased pressure in the eye.
`
`You may experience temporary visual changes after an EYLEA injection and associated
`eye exams; do not drive or use machinery until your vision recovers sufficiently.
`
`Contact your doctor right away if you think you might be experiencing any side effects,
`including eye pain or redness, light sensitivity, or blurring of vision, after an injection.
`
`For additional safety information, please talk to your doctor and see the full Prescribing
`Information for EYLEA.
`
`You are encouraged to report negative side effects of prescription drugs to the FDA.
`Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
`
`INDICATIONS
`
`EYLEA® (aflibercept) Injection 2 mg (0.05mL) is a prescription medicine approved for the
`treatment of patients with Wet Age-related Macular Degeneration (AMD), Macular Edema
`following Retinal Vein Occlusion (RVO), Diabetic Macular Edema (DME), and Diabetic
`Retinopathy (DR).
`
`Please see the full Prescribing Information for EYLEA.
`
`The information contained herein is provided for general educational purposes. If you have any questions, talk
`to your doctor.
`
`For U.S. Residents Only
`
`EYLEA AND EYLEA4U are registered trademarks of Regeneron Pharmaceuticals, Inc.
`
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`
`Prescribing Information
`For Healthcare Professionals
`
`© 2021, Regeneron Pharmaceuticals, Inc. All rights reserved.
`777 Old Saw Mill River Road, Tarrytown, NY 10591
`
`Find an Eye Doctor
`
`IMPORTANT SAFETY INFORMATION
`
`01/2021
`EYL.20.10.0070
`
`®
`EYLEA (aflibercept) Injection is a prescription medicine administered by injection into the eye. You
`should not use EYLEA if you have an infection in or around the eye, eye pain or redness, or known
`allergies to any of the ingredients in EYLEA, including aflibercept.
`
`https://eylea.us
`
`5/5
`
`Mylan Exhibit 1171
`Mylan v. Regeneron, IPR2021-00881
`Page 5
`
`