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`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet) a...
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`Beovu® (brolucizumab injection) now publicly
`reimbursed in Ontario and New Brunswickfor the
`treatmentof neovascular (wet) age-related macular
`degeneration
`
`December 17, 2021-7 min read W reo, Dx
`
`reo
`
`
`
`
`start on a three-month dosing interval immediately after the loading
`
`° Beovu"is an anti-VEGF that offers the option for eligible patients to
`
`phase with no compromise in efficacy.’
`
`While wet age-related macular degeneration (AMD) represents 10 to
`es
`20 per cent of all AMD cases, it is the most severe form of AMD and
`
`Find family
`getaways nearby
`
`is responsible for 90 per centof vision loss associated with this
`disease?
`
`DORVAL, QC,Dec. 17, 2021 /CNW/- Novartis Pharmaceuticals Canada
`Inc. (Novartis) is pleased to announcethat "Beovu® (brolucizumab
`injection) is now listed on the Ontario Drug Benefit Formulary and the
`New Brunswick Drug Plan for the treatment of neovascular (wet) age-
`related macular degeneration (AMD)for eligible patients.
`
`Ub NOVARTIS
`
`Novartis Logo (CNWGroup/Novartis Pharmaceuticals Canada Inc.)
`
`"We would like to thank the Governments of Ontario and New
`
`Brunswickfor their leadership in making Beovu® accessible foreligible
`
`patients and remain committed to working collaboratively with the
`
`remaining provinces to ensure patients across the country can benefit
`
`from this therapy. Access to this next generation wet AMD treatment
`
`will make a difference to the vision health of Canadians and represents
`
`TRENDING
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`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htm!
`
`1/8
`
`U.S. Pat. 9,254,338, Exhibit 2270
`
`Mylan v. Regeneron, IPR2021-00881
`
`Exhibit 2270
`Page 01 of 08
`
`
`
`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`
`ed Cre
`
`NEWS
`
`aDa
`
`Pty rag LIFE
`
`Pela
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`NAATeLt Sie aidis)
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`yahoo/finance
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`Search for news, symbols
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`or
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`companies
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`Ga me
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`Affecting more than 2.5 million Canadians, AMDis a chronic disease of
`
`the retina that causes progressive loss of central vision and is the
`leading causeofvision loss in people over the age of 50.45 There are
`two types of AMD - dry and wet.‘ In wet AMD,new blood vessels grow
`under the macula and leak fluid into the eye causing scarring of the
`macula.’ Left untreated, wet AMD canlead to profound, rapid, and
`permanentlossof sight.*89 Vision loss has a significant impact on
`people's quality of life and mental health - their autonomyis lost, they
`
`can't drive, read or see the faces of their loved ones, often leading
`
`COLE HAAN
`THE WINTER SALE
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`them to experience feelings of social isolation and depression.?"'
`
`"Given wet AMDcan be aggressivein its progression and has nocure,it
`
`can have a devastating impact on patients and their vision if patients
`
`don't adhereto the regular treatment that is required," said Dr. Peter
`
`Kertes, MD, ophthalmologist and retinal specialist, Sunnybrook
`
`Hospital, Toronto. "As someone who knows how important extended
`
`treatmentintervals can be for patients, | welcome the newsthat
`Beovu® is now publicly funded in these provinces, providing a new
`
`treatment option for wet AMD."
`
`Anti-vascular endothelial growth factor (anti-VEGF) therapyis widely
`regardedas the standard of care for patients with wet AMD."
`Approved by Health Canada in March 2020, Beovu’is an anti-VEGF
`
`that offers the option for eligible patients to start on a three-month
`
`dosing interval immediately after the first three doses (loading
`phase)."2
`
`"Regular treatmentis key to preserving sight and maintaining the
`
`independenceof people living with wet AMD," said Doug Earle,
`
`president and CEO, Fighting Blindness Canada. "It may be challenging
`
`to keep up with frequent appointments, especially for those living in
`
`remote or isolated communities, or requiring mobility assistance.
`
`These issues have further been exacerbated by COVID-19. The
`Governmentsof Ontario and New Brunswick's decision to add Beovu®
`
`to their provincial formularies offers the opportunity to reduce the
`
`burdenof frequent injections and will be meaningful to provide
`
`treatment options for people living with wet AMDand their loved
`ones."
`
`About Beovu® (brolucizumabinjection)
`Beovu® (brolucizumabinjection) is a humanized vascular endothelial
`
`growth factor (VEGF)inhibitor that binds to VEGF-A isoforms, thereby
`
`preventing binding of VEGF-A to its receptors VEGFR-1 and VEGFR-2.
`By inhibiting VEGF-A binding, Beovu® suppresses endothelial cell
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
`
`2/8
`
`Exhibit 2270
`
`Page 02 of 08
`
`Exhibit 2270
`Page 02 of 08
`
`
`
`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`
`a aed
`
`Pre
`
`bed
`
`FINANCE
`
`be
`
`Papeterlag
`
`paid Bd YAHOO PLUS
`
`Ptete
`
`yahoo/finance
`
`Search for news, symbols
`
`or
`
`companies
`
`ATT iee
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`COLE HAAN
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`°
`
`f
`v
`
`=
`
`treatment of neovascular (wet) age-related macular degeneration
`(AMD)basedonfindings from the pivotal HAWK and HARRIER Phase
`lll studies.
`
`Thefull prescribing information for Beovu® can be found at:
`www.novartis.ca.
`
`About Novartis in Ophthalmology
`
`At Novartis, our mission is to discover new ways to improve and
`
`extend people'slives. In ophthalmology, we develop and deliverlife-
`
`changing medicines and therapies for diseases and conditions from
`
`front to back of the eye, enabled by data and transformative
`
`technologies. Our ophthalmic solutions reach more than 150 million
`
`people per year, from premature infants to the elderly.
`
`About Novartis Pharmaceuticals CanadaInc.
`
`Novartis Pharmaceuticals CanadaInc., a leader in the healthcare field,
`
`is committed to the discovery, development and marketing of
`
`innovative products to improve the well-being of all Canadians.In
`
`2020, the company invested $45 million in research and development
`
`in Canada. Located in Dorval, Quebec, Novartis Pharmaceuticals
`
`Canada Inc. employs approximately 1,000 people in Canada and is an
`
`affiliate of Novartis AG, which provides innovative healthcare solutions
`
`that address the evolving needs of patients and societies. The
`
`companypridesitself on its commitmentto diversity and to nurturing
`
`an inclusive and inspiring environment. Novartis is recognized as a
`Great Place to Work®, ranked among the Top 50 Best Workplaces™ in
`the country and is proudly named on the 2021 Best Workplaces™ for
`
`Womenin Canada and Best Workplace™ for Mental Wellnesslists. For
`
`further information, please consult www.novartis.ca.
`
`About Novartis
`
`Novartis is reimagining medicine to improve and extend people'slives.
`
`Asa leading global medicines company, we use innovative science and
`
`digital technologies to create transformative treatments in areas of
`
`great medical need. In our quest to find new medicines, we
`
`consistently rank among the world's top companies investing in
`
`research and development. Novartis products reach more than 800
`
`million people globally and weare finding innovative ways to expand
`
`access to ourlatest treatments. About 110,000 people of more than
`140 nationalities work at Novartis around the world. Find out more at
`
`www.novartis.com.
`
`Beovuis a registered trademark.
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
`
`3/8
`
`Exhibit 2270
`
`Page 03 of 08
`
`Exhibit 2270
`Page 03 of 08
`
`
`
`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet) a...
`
`,a
`Pre
`Pay
`aL3
`Bey
`Paessg LIFE Bod BET MORE...
`y/finanl Try it free
`
`Cam
`yahoo/finance symbolsorcompaearch for news,
`
`
`
`
`
`
`
`
`
`COLE HAAN
`THE WINTER SALE
`TAKE AN
`
`SHOP NOW
`
`Extra 30” Off
`SALE STYLES WITH CODE: EXTRA
`
`M
`
`DoubleMasked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.
`Available at: https://www.aaojournal.org/article/SO161-6420(18)33018-5/fulltext. Accessed on
`December2, 2021.
`3 Institut national d'excellence en santé et en services sociaux.Efficacité et innocuité de la
`monothérapie antiangiogénique dans le traitement de la dégénérescence maculaire liée a l'age.
`Available at:
`https://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/DMLA/Note_informative_DMLA.pdf.
`Accessed on December2, 2021.
`4 Medscape. Age-Related Macular Degeneration. Available at:
`https://www.medscape.com/viewarticle/848348_print. Accessed on December2, 2021.
`5 Fighting Blindness Canada. AMD Survey. Available at:
`https://www.fightingblindness.ca/amdsurvey/. Accessed on December 2, 2021.
`6 Canadian Council of the Blind. The Cost of Vision Loss and Blindness in Canada. Available at:
`https://www.fightingblindness.ca/wp-content/upl oads/2021/05/Deloitte-Final-Acc-of-V L-and-
`Blindness-in-Canada-May-2021.pdf. Accessed on December2, 2021.
`7 American Academy of Ophthalmology. What is Macular Degeneration? Available at:
`https://www.aaoorg/eye-health/diseases/amd-macular-degeneration. Accessed on December2,
`2021.
`
`8 Fighting Blindness Canada. Age Related Macular Degeneration. Availableat:
`https://www.fightingblindness.ca/eyeheal th/eye-diseases/age-related-macular-degeneration/.
`Accessed on December2, 2021.
`° Wykoff CC et al. Optimizing Anti-VEGF Treatment Outcomesfor Patients with Neovascular Age-
`Related Macular Degeneration. J Manag Care Spec Pharm. 2018 Feb.Available at:
`https://pubmed.ncbi.nim.nih.gov/29383980/. Accessed on December2, 2021.
`10 American Macular Degeneration Foundation. Depression in Age-related Macular Degeneration.
`Available at: https://www.macularorg/depression-amd-arnold-wyse-md. Accessed on December2,
`2021.
`
`" CADTH Therapeutic Report. Anti-Vascular Endothelial Growth Factor Drugs for the Treatment of
`Retinal Conditions Recommendations Report. 2016.Available at:
`https://www.cadth.ca/sites/default/files/pdf/TROOO9_Anti-VEGFs_Recs_Report.pdf. Accessed on
`December2, 2021.
`
`SOURCENovartis Pharmaceuticals Canada Inc.
`
`Cision
`
`View original content to download multimedia:
`
`http://www.newswire.ca/en/releases/archive/December2021/17/c0757.h
`tml
`
`+22 point >WAKO pb1
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htm!
`
`4/8
`
`Exhibit 2270
`
`Page 04 of 08
`
`Exhibit 2270
`Page 04 of 08
`
`
`
`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`
`ed Cre
`
`NEWS
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`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
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`5/8
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`Exhibit 2270
`
`Page 05 of 08
`
`Exhibit 2270
`Page 05 of 08
`
`
`
`12/30/21, 6:31 PM
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`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
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`Exhibit 2270
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`Page 06 of 08
`
`Exhibit 2270
`Page 06 of 08
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`
`
`12/30/21, 6:31 PM
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`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
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`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
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`Exhibit 2270
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`
`Exhibit 2270
`Page 07 of 08
`
`
`
`12/30/21, 6:31 PM
`
`a Cre
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`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
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`8/8
`
`Exhibit 2270
`
`Page 08 of 08
`
`Exhibit 2270
`Page 08 of 08
`
`