12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet) a...
`
`
`
`
`
`
`
`
`
`
`
`,ed Cre NEWS DTa4 Pott Parlg PET3 Pred Oey) fT. NAATeLt Try it free
`
`
`
`yahoo/finance
`
`sins)
`
`fg Mau
`
`°
`f
`
`¥
`
`ar879
`14.33(0.30%)
`
`/
`
`CISION
`
`
`
`36,398.08
`90.55(-0.25%) ering
`
`‘s7m56 | er
`24.65(-0.16%)
`“OAS(-0.02%) LMR,
`
`sed
`
`
`a Tatiana MW.
`
`Eee
`Seehit22 point
`GEREVNN
`— increase
`Tkmergyeg
`
`TAKE AN
`%
`Extra 30” Off
`SALE STYLES WITH CODE: EXTRA
`SHOP NOW
`
`
`hoo/
`bay|a
`ieeewe
`
`Beovu® (brolucizumab injection) now publicly
`reimbursed in Ontario and New Brunswickfor the
`treatmentof neovascular (wet) age-related macular
`degeneration
`
`December 17, 2021-7 min read W reo, Dx
`
`reo
`
`
`
`
`start on a three-month dosing interval immediately after the loading
`
`° Beovu"is an anti-VEGF that offers the option for eligible patients to
`
`phase with no compromise in efficacy.’
`
`While wet age-related macular degeneration (AMD) represents 10 to
`es
`20 per cent of all AMD cases, it is the most severe form of AMD and
`
`Find family
`getaways nearby
`
`is responsible for 90 per centof vision loss associated with this
`disease?
`
`DORVAL, QC,Dec. 17, 2021 /CNW/- Novartis Pharmaceuticals Canada
`Inc. (Novartis) is pleased to announcethat "Beovu® (brolucizumab
`injection) is now listed on the Ontario Drug Benefit Formulary and the
`New Brunswick Drug Plan for the treatment of neovascular (wet) age-
`related macular degeneration (AMD)for eligible patients.
`
`Ub NOVARTIS
`
`Novartis Logo (CNWGroup/Novartis Pharmaceuticals Canada Inc.)
`
`"We would like to thank the Governments of Ontario and New
`
`Brunswickfor their leadership in making Beovu® accessible foreligible
`
`patients and remain committed to working collaboratively with the
`
`remaining provinces to ensure patients across the country can benefit
`
`from this therapy. Access to this next generation wet AMD treatment
`
`will make a difference to the vision health of Canadians and represents
`
`TRENDING
`gg,
`Aan MeySet LC From Cine Stocka aly
`“in U.S. Markets Wrap
`
`2 UPDATE1-Putin told Biden new sanctions
`could rupture U.S.-Russia ties - Kremlin
`
`w
`
`Germany's Scholz wants G7 to be pioneer
`for climate-friendly growth
`
`>
`
`Libor Banks Subject to U.S. Conspiracy
`Jurisdiction, Court Says
`
`yi
`
`Bidentold Putin U.S.will respond
`decisively if further invasion of Ukraine -
`White House
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htm!
`
`1/8
`
`U.S. Pat. 9,254,338, Exhibit 2270
`
`Mylan v. Regeneron, IPR2021-00881
`
`Exhibit 2270
`Page 01 of 08
`
`

`

`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`
`ed Cre
`
`NEWS
`
`aDa
`
`Pty rag LIFE
`
`Pela
`
`beruyy
`
`ae
`
`NAATeLt Sie aidis)
`
`yahoo/finance
`
`Search for news, symbols
`
`or
`
`companies
`
`Ga me
`
`f
`
`Affecting more than 2.5 million Canadians, AMDis a chronic disease of
`
`the retina that causes progressive loss of central vision and is the
`leading causeofvision loss in people over the age of 50.45 There are
`two types of AMD - dry and wet.‘ In wet AMD,new blood vessels grow
`under the macula and leak fluid into the eye causing scarring of the
`macula.’ Left untreated, wet AMD canlead to profound, rapid, and
`permanentlossof sight.*89 Vision loss has a significant impact on
`people's quality of life and mental health - their autonomyis lost, they
`
`can't drive, read or see the faces of their loved ones, often leading
`
`COLE HAAN
`THE WINTER SALE
`TAKE AN0,
`Extra 30” Off
`SALE STYLES WITH CODE: EXTRA
`SHOP NOW
`
`them to experience feelings of social isolation and depression.?"'
`
`"Given wet AMDcan be aggressivein its progression and has nocure,it
`
`can have a devastating impact on patients and their vision if patients
`
`don't adhereto the regular treatment that is required," said Dr. Peter
`
`Kertes, MD, ophthalmologist and retinal specialist, Sunnybrook
`
`Hospital, Toronto. "As someone who knows how important extended
`
`treatmentintervals can be for patients, | welcome the newsthat
`Beovu® is now publicly funded in these provinces, providing a new
`
`treatment option for wet AMD."
`
`Anti-vascular endothelial growth factor (anti-VEGF) therapyis widely
`regardedas the standard of care for patients with wet AMD."
`Approved by Health Canada in March 2020, Beovu’is an anti-VEGF
`
`that offers the option for eligible patients to start on a three-month
`
`dosing interval immediately after the first three doses (loading
`phase)."2
`
`"Regular treatmentis key to preserving sight and maintaining the
`
`independenceof people living with wet AMD," said Doug Earle,
`
`president and CEO, Fighting Blindness Canada. "It may be challenging
`
`to keep up with frequent appointments, especially for those living in
`
`remote or isolated communities, or requiring mobility assistance.
`
`These issues have further been exacerbated by COVID-19. The
`Governmentsof Ontario and New Brunswick's decision to add Beovu®
`
`to their provincial formularies offers the opportunity to reduce the
`
`burdenof frequent injections and will be meaningful to provide
`
`treatment options for people living with wet AMDand their loved
`ones."
`
`About Beovu® (brolucizumabinjection)
`Beovu® (brolucizumabinjection) is a humanized vascular endothelial
`
`growth factor (VEGF)inhibitor that binds to VEGF-A isoforms, thereby
`
`preventing binding of VEGF-A to its receptors VEGFR-1 and VEGFR-2.
`By inhibiting VEGF-A binding, Beovu® suppresses endothelial cell
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
`
`2/8
`
`Exhibit 2270
`
`Page 02 of 08
`
`Exhibit 2270
`Page 02 of 08
`
`

`

`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`
`a aed
`
`Pre
`
`bed
`
`FINANCE
`
`be
`
`Papeterlag
`
`paid Bd YAHOO PLUS
`
`Ptete
`
`yahoo/finance
`
`Search for news, symbols
`
`or
`
`companies
`
`ATT iee
`
`Sw
`
`COLE HAAN
`THE WINTER SALE
`TAKE AN
`
`SHOP NOW
`
`Extra 30” Off
`SALE STYLES WITH CODE: EXTRA
`
`°
`
`f
`v
`
`=
`
`treatment of neovascular (wet) age-related macular degeneration
`(AMD)basedonfindings from the pivotal HAWK and HARRIER Phase
`lll studies.
`
`Thefull prescribing information for Beovu® can be found at:
`www.novartis.ca.
`
`About Novartis in Ophthalmology
`
`At Novartis, our mission is to discover new ways to improve and
`
`extend people'slives. In ophthalmology, we develop and deliverlife-
`
`changing medicines and therapies for diseases and conditions from
`
`front to back of the eye, enabled by data and transformative
`
`technologies. Our ophthalmic solutions reach more than 150 million
`
`people per year, from premature infants to the elderly.
`
`About Novartis Pharmaceuticals CanadaInc.
`
`Novartis Pharmaceuticals CanadaInc., a leader in the healthcare field,
`
`is committed to the discovery, development and marketing of
`
`innovative products to improve the well-being of all Canadians.In
`
`2020, the company invested $45 million in research and development
`
`in Canada. Located in Dorval, Quebec, Novartis Pharmaceuticals
`
`Canada Inc. employs approximately 1,000 people in Canada and is an
`
`affiliate of Novartis AG, which provides innovative healthcare solutions
`
`that address the evolving needs of patients and societies. The
`
`companypridesitself on its commitmentto diversity and to nurturing
`
`an inclusive and inspiring environment. Novartis is recognized as a
`Great Place to Work®, ranked among the Top 50 Best Workplaces™ in
`the country and is proudly named on the 2021 Best Workplaces™ for
`
`Womenin Canada and Best Workplace™ for Mental Wellnesslists. For
`
`further information, please consult www.novartis.ca.
`
`About Novartis
`
`Novartis is reimagining medicine to improve and extend people'slives.
`
`Asa leading global medicines company, we use innovative science and
`
`digital technologies to create transformative treatments in areas of
`
`great medical need. In our quest to find new medicines, we
`
`consistently rank among the world's top companies investing in
`
`research and development. Novartis products reach more than 800
`
`million people globally and weare finding innovative ways to expand
`
`access to ourlatest treatments. About 110,000 people of more than
`140 nationalities work at Novartis around the world. Find out more at
`
`www.novartis.com.
`
`Beovuis a registered trademark.
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
`
`3/8
`
`Exhibit 2270
`
`Page 03 of 08
`
`Exhibit 2270
`Page 03 of 08
`
`

`

`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet) a...
`
`,a
`Pre
`Pay
`aL3
`Bey
`Paessg LIFE Bod BET MORE...
`y/finanl Try it free
`
`Cam
`yahoo/finance symbolsorcompaearch for news,
`
`
`
`
`
`
`
`
`
`COLE HAAN
`THE WINTER SALE
`TAKE AN
`
`SHOP NOW
`
`Extra 30” Off
`SALE STYLES WITH CODE: EXTRA
`
`M
`
`DoubleMasked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.
`Available at: https://www.aaojournal.org/article/SO161-6420(18)33018-5/fulltext. Accessed on
`December2, 2021.
`3 Institut national d'excellence en santé et en services sociaux.Efficacité et innocuité de la
`monothérapie antiangiogénique dans le traitement de la dégénérescence maculaire liée a l'age.
`Available at:
`https://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/DMLA/Note_informative_DMLA.pdf.
`Accessed on December2, 2021.
`4 Medscape. Age-Related Macular Degeneration. Available at:
`https://www.medscape.com/viewarticle/848348_print. Accessed on December2, 2021.
`5 Fighting Blindness Canada. AMD Survey. Available at:
`https://www.fightingblindness.ca/amdsurvey/. Accessed on December 2, 2021.
`6 Canadian Council of the Blind. The Cost of Vision Loss and Blindness in Canada. Available at:
`https://www.fightingblindness.ca/wp-content/upl oads/2021/05/Deloitte-Final-Acc-of-V L-and-
`Blindness-in-Canada-May-2021.pdf. Accessed on December2, 2021.
`7 American Academy of Ophthalmology. What is Macular Degeneration? Available at:
`https://www.aaoorg/eye-health/diseases/amd-macular-degeneration. Accessed on December2,
`2021.
`
`8 Fighting Blindness Canada. Age Related Macular Degeneration. Availableat:
`https://www.fightingblindness.ca/eyeheal th/eye-diseases/age-related-macular-degeneration/.
`Accessed on December2, 2021.
`° Wykoff CC et al. Optimizing Anti-VEGF Treatment Outcomesfor Patients with Neovascular Age-
`Related Macular Degeneration. J Manag Care Spec Pharm. 2018 Feb.Available at:
`https://pubmed.ncbi.nim.nih.gov/29383980/. Accessed on December2, 2021.
`10 American Macular Degeneration Foundation. Depression in Age-related Macular Degeneration.
`Available at: https://www.macularorg/depression-amd-arnold-wyse-md. Accessed on December2,
`2021.
`
`" CADTH Therapeutic Report. Anti-Vascular Endothelial Growth Factor Drugs for the Treatment of
`Retinal Conditions Recommendations Report. 2016.Available at:
`https://www.cadth.ca/sites/default/files/pdf/TROOO9_Anti-VEGFs_Recs_Report.pdf. Accessed on
`December2, 2021.
`
`SOURCENovartis Pharmaceuticals Canada Inc.
`
`Cision
`
`View original content to download multimedia:
`
`http://www.newswire.ca/en/releases/archive/December2021/17/c0757.h
`tml
`
`+22 point >WAKO pb1
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htm!
`
`4/8
`
`Exhibit 2270
`
`Page 04 of 08
`
`Exhibit 2270
`Page 04 of 08
`
`

`

`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`
`ed Cre
`
`NEWS
`
`aDa
`
`Pty rg nt
`
`Peal
`
`berry
`
`an
`
`NAATeLt Sie aidis)
`
`yahoo/finance
`
`Search for news, symbolsor
`
`companies
`
`—
`
`Popular in the Community
`QO
`
`f
`
`¥
`
`=m
`
`Invest in
`a career
`where the
`demandis
`growi ng
`Train to be
`
`}
`
`|
`
`a paralegal!
`
`COLE HAAN
`THE WINTER SALE
`ww
`Extra 30” Off
`SALE STYLES WITH CODE: EXTRA
`SHOP Now
`
`AdChoices [>
`
`Sponsored
`
`
`
`____ RECOMMENDEDSTORIES
`
`MarketWatch
`
`SHOP NOW
`
`Daily average of COVID-19 cases surges past 300,000,but more
`data emerge suggesting omicronis less dangerous
`There are a lot more people sick with COVID-19 today than ever before, but
`evidenceis piling up to suggest the surging omicronvariant is less severe
`than the previously dominantdelta variant.
`6h ago
`
`TipRanks
`These 2 “Strong Buy” Penny Stocks Are Poised to Take Off, Says
`Raymond James
`Let's talk about penny stocks. These are equities that trade for less than $5
`per share, the very bottom of the price range. While they are priced that
`low for a reason - and the reasons mayvary - low price in itself doesn't...
`1d ago
`
`Ad + Chaikin Analytics
`7
`.
`ove
`Wall Street legend warns “A strange day is coming”
`A massive and surprising new transition could soon impact the wealth of
`thousands, while leaving everyone else worse off than before.
`
`
`
`COLE HAAN
`THE WINTER SALE
`TAKE AN
`
`0
`9%
`Extra 30 Off
`SALE STYLES WITH CODE: EXTRA
`
`Yahoo Finance
`
`Why Wall Street set new records on the same day COVID-19 cases did
`Anotherday, another shattered record of COVID-19 infections in the United States — and yet another set of new
`milestones in the Dow and S&P 500,as Santa Claus continues to bestow gifts on Wall Street.
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
`
`5/8
`
`Exhibit 2270
`
`Page 05 of 08
`
`Exhibit 2270
`Page 05 of 08
`
`

`

`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`
`ed Cre
`
`NEWS
`
`aDa
`
`Pty rag LIFE
`
`Pela
`
`Perot
`
`ae
`
`NAATeLt Sie aidis)
`
`yahoo/finance
`
`Search for news, symbols
`
`or companies
`
`Ga Mail
`
`Not even the governmentis
`
`sure whetheryou'll end up paying moreor payingless.
`
`American City Business Journals
`Cancer research company,insurance agencylease at SkySong
`Office leasing activity continues in the Scottsdale area despite the
`continuing pandemic. One of the new tenants at SkySong is NeoGenomics
`Inc., a publicly-traded cancer research firm.
`1d ago
`
`Ad + Stansberry Research
`Renowned Stock-picker Names Best Stock of 2022
`After discovering FORTY 1,000% winners, he just announcedhis favorite
`stock of the year. Get the nameandticker.
`
`o
`
`1d ago
`
`COLE HAAN
`
`THE WINTER SALE
`TAKE AN
`0
`Off
`”
`Extra 30 O
`male amteenirniCopEtnrna
`SHOP NOW
`
`©
`
`f
`
`’
`
`= =
`
`Barrons.com
`
`Johnson & Johnson Booster Dose Cuts Omicron Hospitalizations:
`Study
`A booster dose of Johnson & Johnson's Covid-19 vaccine was up to 85%
`effective at preventing hospitalizations caused by the Omicronvariantin
`South Africa, according to a study.
`10h ago
`
`LA Times
`
`Whatshould| do if | test positive for the coronavirus?
`The winter spread of coronavirus casesis worsening. Here's the latest
`advice on protecting yourself and those around you.
`
`1d ago
`
`Washington Post
`
`They wereso careful, for so long. They got covid anyway.
`WASHINGTON- Fareha Ahmed had been cautioussince the beginning of
`the pandemic. She had eatenin restaurants only three times. She and her
`husband were vaccinated and boosted, and their 7-year-old got vaccinate...
`
`1d ago
`
`Ad + The Penny Hoarder
`If You Have $1,000 in the Bank, Make These 4 Moves
`If you've got more than $1,000 in your checking account, you need to make
`these moves as fast as possible.
`
`ooo
`
`HuffPost Life
`The Best N95 And KN95Face Masks To Wear For COVID Variants
`It might be time to step up from clothif you're in an area with high
`transmission.
`
`12h ago
`
`Eat This, Not That!
`
`I'ma Virus Expert and Here's How to Avoid Omicron
`Omicron is quickly spreading across the U.S. and while doctorsarestill
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
`
`6/8
`
`Exhibit 2270
`
`Page 06 of 08
`
`Exhibit 2270
`Page 06 of 08
`
`

`

`12/30/21, 6:31 PM
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`
`ed Cre
`
`NEWS
`
`aDa
`
`Pty rag LIFE
`
`Pela
`
`beruyy
`
`ae
`
`NAATeLt Sie aidis)
`
`yahoo/finance
`
`Search for news, symbols
`
`or
`
`companies
`
`Ga me
`
`COLE HAAN
`THE WINTER SALE
`TAKE AN
`
`SHOP NOW
`
`0
`Extra 30” Off
`SALE STYLES WITH CODE: EXTRA
`
`OQ
`
`f
`
`v
`na
`<=
`
`How totellif it's COVID, a
`cold, or theflu
`Pima County Health
`Departmentsaystesting is
`available for everyone.
`2d ago
`
`Ad + The Motley Fool
`This Stock Might Set You Upfor Life*
`Could This Be the Smartest Stock Pickin Silicon Valley Right Now?
`
`_
`
`Yahoo Entertainment
`
`Why Chris Hayes claims Omicronis ‘one of the weirdest’
`moments of the pandemic
`On Wednesday, the MSNBC host explained why he believes Omicron's
`contagiousnessis changing the pandemic normal.
`
`17h ago
`
`Yahoo Finance
`
`Omicron:U.S.testing failures are ‘morally scandalous,’ doctor
`says
`Testing has becomea core focus as the US. tries to contain the spread of
`the omicron variant, which now accounts for 58.6% of all COVID casesin
`the country.
`10h ago
`
`Washington Post
`
`A respiratory therapist fought on covid's front lines. The last
`wave broke him.
`ROANOKE, Va. - Respiratory therapist Alva Daniels fought in covid hot
`spots throughout the pandemic, but it was only in recent monthsthat the
`strain began to show.Hestarted calling his wife from the hospital...
`1d ago
`
`Ad + CompareCredit™
`New Card Hits The Market With 0% APRFor 21 Months
`Get nearly 2 years to pay down your holiday debt and up to $600 ofcell
`phoneprotectionall with no annualfee!
`
`eee
`
`Miami Herald
`
`Company recalls a diabetes drug because it might have too much
`of a carcinogen
`Recall alert: Check your diabetes medication
`
`1d ago
`
`Best Life
`
`Walmart Just Made a Major COVID Announcement for
`Customers
`From public mask mandates to employee vaccine requirements,retailersall
`across the U.S. have had to adapt to work during the coronavirus
`pandemic. Andthefightis far from over. Just this month alone, Walmart...
`2h ago
`
`Austin American-Statesman
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htmI
`
`7/8
`
`Exhibit 2270
`
`Page 07 of 08
`
`Exhibit 2270
`Page 07 of 08
`
`

`

`12/30/21, 6:31 PM
`
`a Cre
`
`NEWS
`
`Beovu® (brolucizumabinjection) now publicly reimbursed in Ontario and New Brunswickfor the treatment of neovascular (wet)a...
`MORE...
`aL3
`Bey
`Paessg LIFE Bod BET
`
`NATLae
`
`yahoo/finance
`
`Sear
`
`yr
`
`News,
`
`symbols
`
`or
`
`companies
`
`Sw
`
`COLE HAAN
`THE WINTER SALE
`TAKE AN
`
`SHOP NOW
`
`Extra 30” Off
`SALE STYLES WITH CODE: EXTRA
`
`M
`
`Ad + BleacherBreaker
`
`aad
`
`Closing Time:All The
`Restaurant Chains Closing
`If your favorite restaurantis on
`this list, we've got some bad
`newsfor you...
`
`MarketWatch
`
`California first state to top 5 million COVID cases amid omicron
`surge
`Thefirst coronaviruscasein California was confirmed Jan. 25, 2020.It took
`292 days to get to1 million infections on Nov.11 of that year, and 44 days
`from then to top 2 million.
`2d ago
`
`Motley Fool
`My2 Favorite Healthcare Stocks for 2022
`The pandemic may have brought these companies to prominence, but
`there's much moreto thestory.
`
`1d ago
`
`CountryLiving
`
`Ree Drummond,52, Says "Small" Lifestyle Changes Helped Her
`Lose Nearly 60 Pounds
`Ree Drummondsaid she lost nearly 60 poundsbyloading up on protein,
`adding weightlifting to her routine, and reframing her thinking about
`weightloss.
`7h ago
`
`https://inance.yahoo.com/news/beovu-brolucizumab-injection-now-publicly-120000109.htm!
`
`8/8
`
`Exhibit 2270
`
`Page 08 of 08
`
`Exhibit 2270
`Page 08 of 08
`
`