12/2/21, 10:05 AM
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`Photodynamic Therapy for Age-Related Macular Degeneration | Johns Hopkins Medicine
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`ri | RecallonPhilips Respironitant Updates: COVID-19 inati fical devi y
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` ptocynamie Therapy for Age-Related
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`Macular Degeneration
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`@ Eyes (https: //www.hopkinsmedicine.org/health/eyes)
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`@ Eye Care (https://www.hopkinsmedicine.org/health/wellness-and-prevention/eye-care)
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`@ Aging and Vision (https://www.hopkinsmedicine.org/health/wellness-and-prevention/aging-and-vision)
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`@ Correcting and Improving Vision (https://www.hopkinsmedicine.org/health/wellness-and-prevention/correcting-and-improving-vision)
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`Whatis photodynamic therapy for age-related macular
`degeneration?
`
`Photodynamic therapyis a treatmentfor the eyes. It uses a laser and a special medicine that works when exposed to
`a certain typeoflight. It is done to treat age-related macular degeneration (AMD). AMD is a condition that can lead to
`loss of vision.
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`The retina is the layer of cells in the back of your eye that convertslight into electrical signals. Your retina then sends
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`these signals to your brain. AMD affects your macula. The macula is the sensitive, central part of your retina. This area is
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`responsible for your detailed, central vision. AMD damages your macula. The macula may becomethinneras a result.
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`Blood vessels may start growing beneath your retina. This can causefluid to leak beneath your macula. This excess fluid
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`can lead to vision loss.
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`Just before the procedure, an eye doctor injects a medicine into a vein in your arm. This medicineis sensitive to light. It
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`collects in the abnormal blood vessels under your macula. You are then given an anesthetic eye drop. Using a special
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`contact lens, the eye doctor then shinesa laser into your eye. The light from the laser activates the medicine. The
`medicine then creates blood clots in your abnormal bloodvessels. This seals off the vessels. This can help prevent more
`visionloss.
`Mylan v. Regeneron, IPR2021-00881
`U.S. Pat. 9,254,338, Exhibit 2204
`Why might I need photodynamic therapy for age-related macular
`degeneration? Pave 01 of0S
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`Exhibit 2204
`
`https:/Avww.hopkinsmedicine.org/health/treatment-tests-and-therapies/photodynamic-therapy-for-agerelated-macular-degeneration
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`1/5
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`Exhibit 2204
`Page 01 of 05
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`Exhibit 2204
`Page 02 of 05
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`Exhibit 2204
`Page 03 of 05
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`Page 04 of 05
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`Exhibit 2204
`Page 05 of 05
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