`
`Fusion Protein
`The tools of biotechnology can be used to engineer molecules that incorporate genes or portions of genes for two proteins. The resulting
`fusion protein can offer a combination of attributes that enhance its ability to treat disease.
`
`For example, several fusion proteins have been constructed by combining the binding domain of a cell surface
`receptor with the tail (Fc) por ion of an antibody. The receptor portion functions as a decoy binding site to attract
`and capture molecules that would otherwise contribute to disease. The antibody por ion enables the fusion
`protein to remain in the body much longer than a circulating receptor would last on its own.
`
`A fusion protein combines the attributes of more than one protein in a way that enhances its ability to treat disease.
`
`The Shape of Drugs to Come
`
`Select a modality to explore
`
`Antibody Drug Conjugate
`(/stories/2018/08/the-shape-of-
`drugs-to-come/antibody-drug-
`conjugate)
`
`Bispecific Antibody
`(/stories/2018/08/the-shape-of-
`drugs-to-come/bispecific-
`antibody)
`
`BiTE Molecule
`®
`(/stories/2018/08/the-shape-of-
`drugs-to-come/bite-molecule)
`
`Car T Cell
`(/stories/2018/08/the-shape-of-
`drugs-to-come/car-t-cell)
`
`Exhibit 2153
`Page 01 of 02
`
`
`
`Fusion Protein
`(/stories/2018/08/the-shape-of-
`drugs-to-come/fusion-protein)
`
`Monoclonal Antibody
`(/stories/2018/08/the-shape-of-
`drugs-to-come/monoclonal-
`antibody)
`
`Oncolytic Immunotherapy Virus
`(/stories/2018/08/the-shape-of-
`drugs-to-come/oncolytic-
`immunotherapy-virus)
`
`Peptibody
`(/stories/2018/08/the-shape-of-
`drugs-to-come/peptibody)
`
`Peptide
`(/stories/2018/08/the-shape-of-
`drugs to come/peptide)
`
`RNA Interference
`(/stories/2018/08/the-shape-of-
`drugs to come/rna interference)
`
`Small Molecule
`(/stories/2018/08/the-shape-of-
`drugs to come/small molecule)
`
`Therapeutic Protein
`(/stories/2018/08/the-shape-of-
`drugs to come/therapeutic
`protein)
`
` (/)
`
`© 1996-2021 Amgen Inc. All Rights Reserved.
`
`Exhibit 2153
`Page 02 of 02
`
`
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