`
`\ . National Eye Institute
`
`Ila"./ Research Today ... Vislon Tomorrow
`Treatments for Wet AMD
`(Advanced Neovascular
`AMD)
`
`On this page: Anti-VEGF injections Photody:namic theraP-.Y-
`
`Age-related macular degeneration (AMD) is an eye disease that can blur the center of your
`vision. Wet AMD (also called advanced neovascular AMD) is a serious type of late AMD. It
`happens when a protein called vascular endothelial growth factor (VEGF) makes abnormal
`blood vessels grow in the wrong place in the back of your eye.
`
`The good news is that there are effective treatments for wet AMD.
`
`Learn more aboutAMD
`
`(https://nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/age-related(cid:173)
`macular-degeneration)
`There are 2 treatment options that can slow down or stop vision loss from wet AMD:
`
`• Anti-VEGF injections
`
`• Photodynamic therapy (PDT)
`
`If you have vision loss from wet AM D, ask your eye doctor if either of these treatments
`could help you.
`
`Ask your doctor about supplements for AMD
`If you have intermediate AMD in 1 or both eyes, special dietary supplements
`(vitamins and minerals) can help stop it from turning into late AMD.
`
`Learn about supplements for AMP
`(https://nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/age-
`https:11www.nei.nih.gov11eam-about-eye-hea1thteye-conditions-and-<1iseases1age-re1ated-macu1ar-<1egeneration1treatments-wet-amd-advanced-neovascu1ar-amd
`
`Novartis Exhibit 2277.001
`Regeneron v. Novartis, IPR2021-00816
`
`
`
`related-macular-degeneration/nutritional-supplements-age-related-macular(cid:173)
`degeneration)
`What are anti-VEGF injections?
`
`The most common treatment doctors use to slow vision loss from wet AMD is called anti(cid:173)
`VEGF injections. These medicines help stop bleeding and leaking from blood vessels in the
`back of your eye. Most people with wet AMD will get anti-VEGF injections as their only
`treatment.
`
`When you get this treatment, your doctor will:
`
`• Put numbing medicine in your eye
`
`• Clean your eye to keep it from getting infected
`
`• Put the anti-VEGF medicine into your eye with a very small needle
`
`Anti-VEGF injections usually only work for a short time, so most people need to get
`them many times. At first, most people need injections once a month. After that, your
`doctor will tell you how often you need injections to help stop vision loss from AMD.
`
`What is photodynamic therapy (PDT)?
`
`Photodynamic therapy (PDT) is a much less common treatment for wet AMD that doctors
`sometimes use along with anti-VEGF injections.
`
`PDT works by using a light-sensitive medicine called verteporfin that "turns on" when hit
`by a specific type of laser (sometimes called a cold laser). Your doctor will shine the laser
`on a very small area in the back of your eye, causing the verteporfin to break down the
`blood vessels that are causing your vision loss.
`
`When you get this treatment, your doctor will:
`
`• Give a shot of verteporfin in your arm
`
`• Put numbing medicine in your eye
`
`• Place a special contact lens on your eye to help guide the laser
`
`• Shine the laser onto the extra blood vessels in the back of your eye
`
`Some people will need to get PDT more than once. Talk to your doctor to find out if
`you will need more treatments to help stop vision loss from AMD.
`
`
`https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/age-related-macular-degeneration/treatments-wet-amd-advanced-neovascular-amd
`
`Novartis Exhibit 2277.002
`Regeneron v. Novartis, IPR2021-00816
`
`
`
`Last updated: June 22, 2021
`
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`Contact Us(https://nei.nih.gov/contact-us/)
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`
`For NEI Employees
`
`https://www.nei.nih.gov/leam-about-eye-health/eye-conditions-and-diseases/age-related-macular-degeneration/treatments-wet-amd-advanced-neovascular-amd
`
`Novartis Exhibit 2277.003
`Regeneron v. Novartis, IPR2021-00816
`
`
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