I 1111111111111111 1111111111 lllll lllll lllll 111111111111111 111111111111111111
`US010517484B2
`
`c12) United States Patent
`Islam
`
`(IO) Patent No.: US 10,517,484 B2
`(45) Date of Patent:
`*Dec. 31, 2019
`
`(54) SEMICONDUCTOR DIODES-BASED
`PHYSIOLOGICAL MEASUREMENT DEVICE
`WITH IMPROVED SIGNAL-TO-NOISE
`RATIO
`
`(71) Applicant: Omni Medsci, Inc., Ann Arbor, MI
`(US)
`
`(72)
`
`Inventor: Mohammed N. Islam, Ann Arbor, MI
`(US)
`
`(73) Assignee: Omni Medsci, Inc., Ann Arbor, MI
`(US)
`
`(56)
`
`References Cited
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`4,063,106 A
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`12/1977 Ashkin et al.
`6/ 1979 Sakoe et al.
`(Continued)
`
`FOREIGN PATENT DOCUMENTS
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`CA
`CN
`
`5/2012
`2 458 123
`7/2013
`101849821 B
`(Continued)
`
`( *) Notice:
`
`Subject to any disclaimer, the term ofthis
`patent is extended or adjusted under 35
`U.S.C. 154(b) by 0 days.
`This patent is subject to a terminal dis(cid:173)
`claimer.
`
`OTHER PUBLICATIONS
`
`U.S. Appl. No. 61/350,673; titled: Opticoustic Sensor; Inventor:
`Massi Joe E. Kiani; filed Jun. 2, 2010.
`(Continued)
`
`(21) Appl. No.: 16/506,885
`
`(22) Filed:
`
`Jul. 9, 2019
`
`(65)
`
`Prior Publication Data
`US 2019/0328235 Al
`Oct. 31, 2019
`Related U.S. Application Data
`
`(60) Continuation of application No. 16/272,069, filed on
`Feb. 11, 2019, which is a continuation of application
`(Continued)
`
`(51)
`
`Int. Cl.
`G0JJ 5102
`A61B 5100
`
`(2006.01)
`(2006.01)
`(Continued)
`
`(52) U.S. Cl.
`CPC .......... A61B 510088 (2013.01); A61B 510013
`(2013.01); A61B 510022 (2013.01);
`(Continued)
`( 58) Field of Classification Search
`CPC ........... GOIN 21/3581; GOIN 21/3563; GOIN
`21/35; GOIN 21/4738; GOIN 21/55;
`(Continued)
`
`Primary Examiner - Md M Rahman
`(74) Attorney, Agent, or Firm - Brooks Kushman P.C.
`
`(57)
`
`ABSTRACT
`
`A wearable device includes a measurement device to mea(cid:173)
`sure a physiological parameter adapted to be placed on a
`wrist or an ear of a user. A plurality of semiconductor light
`sources such as light emitting diodes generate corresponding
`output light having an initial light intensity. A receiver
`includes spatially separated detectors receiving reflected
`light from the output lights and coupled to analog to digital
`converters. The receiver is configured to synchronize to the
`semiconductor source(s). The measurement device improves
`signal-to-noise ratio of the output signal by increasing light
`intensity relative to the initial light intensity and by increas(cid:173)
`ing a pulse rate. Further improvement in signal-to-noise
`ratio is achieved by using change detection, where the
`receiver compares the signals with light on and with light
`off.
`
`23 Claims, 34 Drawing Sheets
`
`21:JO
`i
`
`2105
`/
`
`D··········\ 211l4 T '6
`
`2101
`
`PRE-AMP
`
`{
`2:02
`
`POWER-AMP
`l
`2100
`
`Petitioner Apple Inc. – Ex. 1001, p. 1
`
`

`

`US 10,517,484 B2
`Page 2
`
`Related U.S. Application Data
`
`No. 16/029,611, filed on Jul. 8, 2018, now Pat. No.
`10,201,283, which is a continuation of application
`No. 15/888,052, filed on Feb. 4, 2018, now Pat. No.
`10,136,819, which is a continuation of application
`No. 15/212,549, filed on Jul. 18, 2016, now Pat. No.
`9,885,698, which is a continuation of application No.
`14/650,897, filed as application No. PCT/US2013/
`075700 on Dec. 17, 2013, now Pat. No. 9,494,567,
`application No. 16/506,885, which is a continuation
`of application No. 16/004,359, filed on Jun. 9, 2018,
`which is a continuation of application No. 14/109,
`007, filed on Dec. 17, 2013, now Pat. No. 9,993,159,
`application No. 16/506,885, which is a continuation
`of application No. 16/188,194, filed on Nov. 12, 2018,
`now Pat. No. 10,386,230, which is a continuation of
`application No. 16/004,154, filed on Jun. 8, 2018,
`now Pat. No. 10,126,283, which is a continuation of
`application No. 15/855,201, filed on Dec. 27, 2017,
`now Pat. No. 9,995,722, which is a continuation of
`application No. 15/711,907, filed on Sep. 21, 2017,
`now Pat. No. 9,897,584, which is a division of
`application No. 15/357,225, filed on Nov. 21, 2016,
`now Pat. No. 9,797,876, which is a continuation of
`application No. 14/650,981, filed as application No.
`PCT/US2013/075767 on Dec. 17, 2013, now Pat. No.
`9,500,634, application No. 16/506,885, which is a
`continuation of application No. 16/241,628, filed on
`Jan. 7, 2019, now Pat. No. 10,441,176, which is a
`continuation of application No. 16/015,737, filed on
`Jun. 22, 2018, now Pat. No. 10,172,523, which is a
`continuation of application No. 15/594,053, filed on
`May 12, 2017, now Pat. No. 10,188,299, which is a
`continuation of application No. 14/875,709, filed on
`Oct. 6, 2015, now Pat. No. 9,651,533, which is a
`continuation of application No. 14/108,986, filed on
`Dec. 17, 2013, now Pat. No. 9,164,032, application
`No. 16/506,885, which is a continuation of applica(cid:173)
`tion No. 16/284,514, filed on Feb. 15, 2019, which is
`a continuation of application No. 16/016,649, filed on
`Jun. 24, 2018, now Pat. No. 10,213,113, which is a
`continuation of application No. 15/860,065, filed on
`Jan. 2, 2018, now Pat. No. 10,098,546, which is a
`continuation of application No. 15/686,198, filed on
`Aug. 25, 2017, now Pat. No. 9,861,286, which is a
`continuation of application No. 15/357,136, filed on
`Nov. 21, 2016, now Pat. No. 9,757,040, which is a
`continuation of application No. 14/651,367, filed as
`application No. PCT/US2013/075736 on Dec. 17,
`2013, now Pat. No. 9,500,635.
`
`(60) Provisional application No. 61/747,472, filed on Dec.
`31, 2012, provisional application No. 61/747,553,
`filed on Dec. 31, 2012, provisional application No.
`61/747,485, filed on Dec. 31, 2012, provisional
`application No. 61/747,487, filed on Dec. 31, 2012,
`provisional application No. 61/747,477, filed on Dec.
`31, 2012, provisional application No. 61/754,698,
`filed on Jan. 21, 2013.
`
`(51)
`
`Int. Cl.
`GOIN 2113563
`GOIN 33102
`GOIN 33115
`GOIN 33/44
`
`(2014.01)
`(2006.01)
`(2006.01)
`(2006.01)
`
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2014.01)
`(2014.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`
`GOIN 33/49
`A61B 51145
`A61B 511455
`GOJJ 3102
`GOJJ 3/10
`GOJJ 3/14
`GOJJ 3/28
`GOJJ 3/42
`GOJJ 3/453
`GOIN 21135
`GOIN 211359
`GOIN 21139
`GOIN 21188
`GOIN 21/85
`HOJS 3/067
`GOIN 21/95
`HOJS 3/30
`GOJJ 3/12
`GOJM 3/38
`GOJJ 3/18
`HOJS 3/00
`(52) U.S. Cl.
`CPC .......... A61B 510075 (2013.01); A61B 510086
`(2013.01); A61B 511455 (2013.01); A61B
`5114532 (2013.01); A61B 5114546 (2013.01);
`A61B 514547 (2013.01); A61B 516801
`(2013.01); A61B 517257 (2013.01); A61B
`51742 (2013.01); A61B 517405 (2013.01);
`GOJJ 310218 (2013.01); GOJJ 3/108
`(2013.01); GOJJ 3/14 (2013.01); GOJJ 3/28
`(2013.01); GOJJ 3/2823 (2013.01); GOJJ 3/42
`(2013.01); GOJJ 3/453 (2013.01); GOIN 21135
`(2013.01); GOIN 211359 (2013.01); GOIN
`2113563 (2013.01); GOIN 21139 (2013.01);
`GOIN 21188 (2013.01); GOIN 33102
`(2013.01); GOIN 331025 (2013.01); GOIN
`33115 (2013.01); GOIN 33/442 (2013.01);
`GOIN 33/49 (2013.01); A61B 2562/0233
`(2013.01); A61B 2562/0238 (2013.01); A61B
`2562/146 (2013.01); A61B 2576/02 (2013.01);
`GOJJ 3/1838 (2013.01); GOJJ 2003/104
`(2013.01); GOJJ 2003/1208 (2013.01); GOJJ
`2003/2826 (2013.01); GOJM 3/38 (2013.01);
`GOIN 21/85 (2013.01); GOIN 21/9508
`(2013.01); GOIN 2021/3595 (2013.01); GOIN
`2021/399 (2013.01); GOIN 2201/061
`(2013.01); GOIN 2201/062 (2013.01); GOIN
`2201/06113 (2013.01); GOIN 2201/08
`(2013.01); GOIN 2201/12 (2013.01); GOIN
`2201/129 (2013.01); HOJS 3/0092 (2013.01);
`HOJS 3/06758 (2013.01); HOJS 3/302
`(2013.01)
`
`(58) Field of Classification Search
`CPC ......... GOIN 21/31; GOIN 21/552; G0lJ 3/02;
`G0lJ 3/28; G0lJ 3/42
`USPC .......................................................... 356/300
`See application file for complete search history.
`
`(56)
`
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`Petitioner Apple Inc. – Ex. 1001, p. 2
`
`

`

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`
`Petitioner Apple Inc. – Ex. 1001, p. 3
`
`

`

`US 10,517,484 B2
`Page 4
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`2009130464 Al
`2012135952 Al
`2013012938
`W02013012938 Al
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`10/2010
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`Petitioner Apple Inc. – Ex. 1001, p. 4
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