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`IPR2021-00406
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`United Therapeutics EX2008
`Page 1 of 18
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`IPR2021-00406
`United Therapeutics EX2008
`Page 1 of 18
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`United Therapeutics EX2008
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`United Therapeutics EX2008
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`United Therapeutics EX2008
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`United Therapeutics EX2008
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`United Therapeutics EX2008
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`United Therapeutics EX2008
`Page 7 of 18
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`treatment of PAH related to congenital heart
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`hypertension. These favorable effects of
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`
`and it is still considered the therapy of first
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`choice for patients in the New York Heart
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`Association class IV and the last resort
`
`when other therapies have failed.
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`Despite its demonstrated efficacy,
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`intravenous epoprostenol is far from an ideal
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`kept in a cold pack to avoid degradation at
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`
`several minute half-life of the drug. The cost
`
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`
`also substantial, amounting to $100,000 to
`
`$250,000 annually.
`
`IPR2021-00406
`
`United Therapeutics EX2008
`Page 8 of 18
`
`IPR2021-00406
`United Therapeutics EX2008
`Page 8 of 18
`
`

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`United Therapeutics EX2008
`Page 9 of 18
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`United Therapeutics EX2008
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`United Therapeutics EX2008
`Page 11 of 18
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`United Therapeutics EX2008
`Page 12 of 18
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`United Therapeutics EX2008
`Page 13 of 18
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`United Therapeutics EX2008
`Page 14 of 18
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`United Therapeutics EX2008
`Page 15 of 18
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`United Therapeutics EX2008
`Page 16 of 18
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`United Therapeutics EX2008
`Page 17 of 18
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`United Therapeutics EX2008
`Page 18 of 18
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`IPR2021-00406
`United Therapeutics EX2008
`Page 18 of 18
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`

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