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`Medical therapeutics for pulmonaryarterial hypertension: from basic science
`and clinical trial design to evidence-based medicine.
`Sulica R, Poon M.
`
`Expert Rev Cardiovasc Ther. 2005 Mar:3(2):347-60. doi: 10.1586/14779072.3.2.347.
`PMID: 15853607
`Review.
`
`L 1
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`Left untreated, pulmonary arterial hypertension results in right-ventricular failure and death. There has
`
`been dramatic progress in the treatment of pulmonary arterial hypertension during recent years. A
`remarkable number of randomized-co...
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`Bosentan therapy for pulmonary arterial hypertension.
`Rubin LJ, Badesch DB, Barst RJ, Galie N. Black CM, Keogh A, Pulide T, Frost A, Roux 5, Leconte|,
`
`Cite
`
`Landzberg M, Simonneau G.
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`Share
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`N Engl J Med. 2002 Mar 21:346(12):896-903. dor: 10.1056/NEIMoa012212.
`PMID: 11907289
`Free article.
`Clinical Trial.
`
`Bosentan also improved the Borg dyspnea index and WHO functional class and increased the time to
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`clinical worsening. CONCLUSIONS: The endothelin-receptor antagonist bosentan is beneficial in patients
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`with pulmonary arterial hypertension and is well tol...
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`End points and clinical trial designs in pulmonary arterial hypertension:
`clinical and regulatory perspectives.
`[| Clinical Trial
`Cite
`Hoeper MM, Oudiz RJ, Peacock A, Tapson VF, Hawarth 5G, Frost AE, Torbicki A.
`J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):48S-55S.doi: 10.1016/jjacc.2004.02.010.—_Liquidia's Exhibit 1118
`[_] Meta-Analysis
`Share
`PMID: 15194178
`Free article.
`Review.
`Page 1
`ee ee er Pe egeaee eeae eeoe
`
`— Pandamived Cantrolled
`
`Liquidia's Exhibit 1118
`Page 1
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`

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`Page 1 of
`12
`
`113 results
`1 Medical therapeutics for pulmonary arterial hypertension: from basic science and clinical trial design to evidence-
`based medicine.
`Sulica R, Poon M.
`Expert Rev Cardiovasc Ther. 2005 Mar;3(2):347-60. doi: 10.1586/14779072.3.2.347.
`PMID: 15853607 Review.
`
`2 Bosentan therapy for pulmonary arterial hypertension.
`Rubin LJ, Badesch DB, Barst RJ, Galie N, Black CM, Keogh A, Pulido T, Frost A, Roux S, Leconte I, Landzberg M, Simonneau G.
`N Engl J Med. 2002 Mar 21;346(12):896-903. doi: 10.1056/NEJMoa012212.
`PMID: 11907289 Free article. Clinical Trial.
`
`3 End points and clinical trial designs in pulmonary arterial hypertension: clinical and regulatory perspectives.
`Hoeper MM, Oudiz RJ, Peacock A, Tapson VF, Haworth SG, Frost AE, Torbicki A.
`J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):48S-55S. doi: 10.1016/j.jacc.2004.02.010.
`PMID: 15194178 Free article. Review.
`
`4 Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial
`hypertension: a double-blind, randomized, placebo-controlled trial.
`Simonneau G, Barst RJ, Galie N, Naeije R, Rich S, Bourge RC, Keogh A, Oudiz R, Frost A, Blackburn SD, Crow JW, Rubin LJ; Treprostinil Study Group.
`Am J Respir Crit Care Med. 2002 Mar 15;165(6):800-4. doi: 10.1164/ajrccm.165.6.2106079.
`PMID: 11897647 Clinical Trial.
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`5 Prostanoids for pulmonary arterial hypertension.
`Galiè N, Manes A, Branzi A.
`Am J Respir Med. 2003;2(2):123-37. doi: 10.1007/BF03256644.
`PMID: 14720012 Review.
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`6 Chronic thromboembolic and pulmonary arterial hypertension share acute vasoreactivity properties.
`Ulrich S, Fischler M, Speich R, Popov V, Maggiorini M.
`Chest. 2006 Sep;130(3):841-6. doi: 10.1378/chest.130.3.841.
`PMID: 16963684 Clinical Trial.
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`7 Exercise testing in pulmonary arterial hypertension and in chronic heart failure.
`Deboeck G, Niset G, Lamotte M, Vachiéry JL, Naeije R.
`Eur Respir J. 2004 May;23(5):747-51. doi: 10.1183/09031936.04.00111904.
`PMID: 15176691 Free article. Clinical Trial.
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`8 Effects of lipo-prostaglandin E1 on pulmonary hemodynamics and clinical outcomes in patients with pulmonary arterial
`hypertension.
`Shen J, He B, Wang B.
`Chest. 2005 Aug;128(2):714-9. doi: 10.1378/chest.128.2.714.
`PMID: 16100159 Clinical Trial.
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`9 Beraprost: a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and
`pulmonary arterial hypertension.
`Melian EB, Goa KL.
`Drugs. 2002;62(1):107-33. doi: 10.2165/00003495-200262010-00005.
`PMID: 11790158 Review.
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`10 Acute and chronic effects of sildenafil in patients with pulmonary arterial hypertension.
`Preston IR, Klinger JR, Houtches J, Nelson D, Farber HW, Hill NS.
`Respir Med. 2005 Dec;99(12):1501-10. doi: 10.1016/j.rmed.2005.03.026.
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`Liquidia's Exhibit 1118
`Page 2
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`

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`PMID: 15890512 Free article. Clinical Trial.
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`Liquidia's Exhibit 1118
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`764632302
`
`1A
`
`mbrisentan therapy for pulmonary arterial hypertension.
`by Galie, Nazzareno; Badesch, David B.; Oudiz, Ronald J.; Simonneau, Gerald;
`McGoon, Michael; Keogh, Anne; Frost, Adaani; Zwicke, Diane; Naeije, Robert;
`Shapiro, Shelley; Olschewski, Horst; Rubin, Lewis
` Downloadable archival material
`Language: English
`Publisher: 2005-08
`
`764632335
`
`2T
`
`ransitioning from i.v. epoprostenol to subcutaneous treprostinil in
`pulmonary arterial hypertension.
`by Vachiery, Jean-Luc; Hill, Nicholas; Zwicke, Diane; Barst, Robyn J.; Blackburn,
`Shelmer D.; Naeije, Robert
` Downloadable archival material
`Language: English
`Publisher: 2002-05
`
`98208441
`
`3E
`
`nd points and clinical trial designs in pulmonary arterial hypertension -
`Clinical and regulatory perspectives
`by Marius M Hoeper; Ronald J Oudiz; Andrew Peacock; Victor F Tapson; Sheila
`G Haworth; Adaani E Frost; Adam Torbicki
` Article
`Language: English
`Publication: Journal of the American College of Cardiology. 43, no. 12, (2004): S48
`Publisher: [New York, N.Y.] : Elsevier Biomedical, [c1983-
`
`4932642183
`
`4E
`
`nd points and clinical trial designs in pulmonary arterial hypertension:
`Clinical and regulatory perspectives
`by Marius M Hoeper; Ronald J Oudiz; Andrew Peacock; Victor F Tapson; Sheila
`G Haworth; Adaani E Frost; Adam Torbicki
` Article
`Language: English
`Publication: Journal of the American College of Cardiology: Supplement, v43 n12 (2004-06-16):
`S48-S55
`
`111044573
`
`5E
`
`nd points and clinical trial designs in pulmonary arterial hypertension:
`clinical and regulatory perspectives.
`by MM Hoeper; RJ Oudiz; A Peacock; VF Tapson; SG Haworth; AE Frost; A
`Torbicki
` Article
`Language: English
`Publication: Journal of the American College of Cardiology, 2004 Jun 16; 43(12) Suppl S: 48S-
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`Liquidia's Exhibit 1118
`Page 5
`
`

`

`4643086970
`
`6E
`
`nd points and clinical trial designs in pulmonary arterial hypertension
`by Marius M Hoeper; Ronald J Oudiz; Andrew Peacock; Victor F Tapson; Sheila
`G Haworth; Adaani E Frost; Adam Torbicki
` Article
`Language: English
`Publication: Journal of the American College of Cardiology, v43 n12 (200406): S48-S55
`
`107544413
`
`7C
`
`ardiopulmonary exercise testing and six-minute walk correlations in
`pulmonary arterial hypertension.
`by RJ Oudiz; RJ Barst; JE Hansen; XG Sun; R Garofano; X Wu; K Wasserman
` Article
`Language: English
`Publication: The American journal of cardiology, 2006 Jan 01; 97(1): 123-6
`
`614767672
`
`8P
`
`ulmonary arterial hypertension
`by Azad Raiesdana; Joseph Loscalzo
` Article
`Language: EN
`Publication: Annals of Medicine, 38, no. 2 (2006): 95-110
`Publisher: Informa Healthcare
`
`7777361610
`
`9M
`
`edical therapeutics for pulmonary arterial hypertension: from basic
`science and clinical trial design to evidence-based medicine
`by Roxana Sulica; Michael Poon
` Article
`Language: English
`Publication: Expert Review of Cardiovascular Therapy, v3 n2 (20050301): 347-360
`
`56826816
`10
`Quiet! hospital zone.
`by Richard C Conti; American College of Cardiology.;
` Audiobook on Cassette : Cassette recording
`Language: English
`Publisher: Bethesda, MD : American College of Cardiology, 2004.
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