`EXHIBITS
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`DECEMBER 8, 2021
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`ORAL ARGUMENT
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`EDWARDS LIFESCIENCES CORP. AND EDWARDS LIFESCIENCES LLC
`
`V.
`
`COLIBRI HEART VALVE LLC
`
`U.S. PATENT NO. 9,125,739
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`CASE NO. IPR2020-01649
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`SARAH E. SPIRES, COUNSEL FOR PATENT OWNER
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`THE ’739 INSTITUTED CLAIMS
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`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
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`2
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`The ’739 Instituted Claims
`Claim 1
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`Claim 1 recites:
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`An assembly to treat a native heart valve in a patient, the assembly for use
`in combination with a guidewire, the assembly comprising:
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`a prosthetic heart valve including:
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`a stent member having an inner channel, the stent member collapsible,
`expandable and configured for transluminal percutaneous delivery, wherein
`the stent member includes a tubular structure away from a central portion
`that flares at both ends in a trumpet-like configuration; and
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`a valve means including two to four individual leaflets made of fixed
`pericardial tissue, wherein the valve means resides entirely within the inner
`channel of the stent member, and wherein no reinforcing members reside
`within the inner channel of the stent member;
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`. . .
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`Ex. 1001 at 14:2-16.
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`3
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`The ’739 Instituted Claims
`Claim 1, cont’d
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`Claim 1 recites:
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`An assembly to treat a native heart valve in a patient, the assembly for use
`in combination with a guidewire, the assembly comprising:
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`a prosthetic heart valve including:
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`. . .
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`a delivery system including a pusher member and a moveable sheath, the
`pusher member including a guidewire lumen of the moveable sheath,
`wherein the prosthetic heart valve is collapsed onto the pusher member to
`reside in a collapsed configuration on the pusher member and is restrained
`in the collapsed configuration by the moveable sheath, wherein a distal end
`of the prosthetic heart valve is located at a distal end of the moveable
`sheath, and wherein the valve means resides entirely within the inner
`channel of the stent member in said collapsed configuration and is
`configured to reside entirely within the inner channel of the stent member
`upon deployment in the patient.
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`Ex. 1001 at 14:2-29.
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`4
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`The ’739 Instituted Claims
`Claim 2
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`Claim 2 recites:
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`The assembly of claim 1, wherein the stent member is self-
`expanding.
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`Ex. 1001 at 14:30-31.
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`5
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`The ’739 Instituted Claims
`Claim 3
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`Claim 3 recites:
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`The assembly of claim 2, wherein the stent member comprises
`nitinol.
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`Ex. 1001 at 14:32-33..
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`6
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`The ’739 Instituted Claims
`Claim 4
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`Claim 4 recites:
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`The assembly of claim 1, wherein the stent member includes two
`circles of barbs on an outer surface of the stent member.
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`Ex. 1001 at 14:34-36.
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`The ’739 Instituted Claims
`Claim 5
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`Claim 5 recites:
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`The assembly of claim 1, wherein the pusher member includes a
`controlled release mechanism that can be activated.
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`Ex. 1001 at 14:37-38.
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`8
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` PANIAGUA IS NOT PRIOR ART
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`PANIAGUA IS NOT PRIOR ART
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`S | .)
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`9
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`’739 Patent: Discloses valve means with leaflets
`constructed from multiple pieces of tissue
`material
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`Ex. 1001 at 3:41-44, 55-58, 4:51-59; POR at 19-21; Sur-Reply at 1.
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`’739 Patent: Not limited to specific
`embodiments
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`Ex. 1001 at 13:30-38; Sur-Reply at 1.
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` NO CONTROLLED RELEASE IN
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`NO CONTROLLED RELEASE IN
`BESSLER/KLINT
`BESSLER/KLINT
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`S|D
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`Bessler: Controlled release through
`threads/sutures
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`Ex. 1006 at 7:38-57; Petition at 66; POR at 65-66; Sur-Reply at 4.
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`Petition: No description of controlled
`release in Bessler/Klint
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`Petition at 69; POR at 65-66; Sur-Reply at 4.
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`14
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`Reply: Cannot import combination from different
`embodiment Klint (not cited in Petition)
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`Reply at 16; Sur-Reply at 10.
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`15
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`COLLAPSED ONTO THE PUSHER
`MEMBER ≠ IN CONTACT WITH THE
`PUSHER MEMBER
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`’739 Patent: Pusher Member
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`Ex. 1001 at 11:40-55; Sur-Reply at 12-14.
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`’739 Patent Prosecution History: Collapsed onto
`pusher member ≠ in contact with pusher member
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`Ex. 1002 at 238, 319; POR at 15-17; Sur-Reply at 14-15.
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`’739 Patent Prosecution History: Collapsed onto
`pusher member ≠ in contact with pusher member,
`cont’d
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`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`Ex. 1002 at 423-24; POR at 15-17; Sur-Reply at 14-15.
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`19
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`VALVE COLLAPSED ONTO THE
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`KLINT DOES NOT DISCLOSE A HEART
`KLINT DOES NOT DISCLOSE A HEART
`VALVE COLLAPSED ONTO THE
`PUSHER MEMBER
`PUSHER MEMBER
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`S|D
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`Klint: No disclosure of heart valve
`collapsed onto the pusher member
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`Ex. 1019 at ¶¶ 90-94; POR at 40-45; Sur-Reply at 19-22.
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` NO COMBINATION OF KLINT WITH
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`NO COMBINATION OF KLINT WITH
`BESSLER
`BESSLER
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`S|D
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`22
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`POSA would not have combined
`Klint with Bessler
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`Ex. 1019 at ¶ 94; Ex. 1006 at Fig. 5; POR at 47-48; Sur-Reply at 22-24.
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`HEART VALVE COLLAPSED ONTO
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`LEONHARDT DOES NOT DISCLOSE A
`LEONHARDT DOES NOT DISCLOSE A
`HEART VALVE COLLAPSED ONTO
`ieeden ade
`THE PUSHER MEMBER
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`S|D
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`Leonhardt: Inner catheter ≠ pusher member
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`Ex. 1012 at 7:22-42, 8:23-27; Ex. 1001 at 11:48-55, Claim 5; POR at 34-39; Sur-Reply at 24-25.
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`Leonhardt: No heart valve collapsed onto a
`pusher member
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`Petition at 61-62; POR at 37-39; Sur-Reply at 24-25.
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