throbber
PATENT OWNER ORAL PRESENTATION
`PATENT OWNER ORAL PRESENTATION
`
`UNITED STATES PATENT AND TRADEMARKOFFICE
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`
`RIMFROSTAS.
`
`Petitioner,
`
`V.
`
`AKER BIOMARINE ANTARCTICAS.
`Patent Owner.
`
`IPR2020-01532 (Patent 9.644.169 B2)
`IPR2020-01533 (Patent 9.816.046 B2)
`
`AKER EXHIBIT 2026 SLIDE 0001
`
`AKER EXHIBIT 2026 SLIDE 0001
`
`

`

`INSTITUTED GROUNDS
`
`US PAT NO 9,644,169 (‘169 Patent)
`
`US PAT NO 9,816,046 (‘046 Patent)
`
`All Grounds reply on Breivik II
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0002
`
`

`

`CLAIMS – ‘169 Patent
`
`1. A method of production of krill oil comprising:
`
`a) providing krill;
`
`b) treating said krill to denature lipases and phospholipases in said krill to provide a denatured krill product;
`
`c) storing said denatured krill product for a storage period of from 1 to 24 months;
`
`d) after said storage period, extracting oil from said denatured krill product with a polar solvent to provide a krill
`
`oil with from about 3% to about 15% ether phospholipids w/w of said krill oil astaxanthin esters in amount of greater than
`
`about 100 mg/kg of said krill oil.
`
`4. The method of claim 1, wherein said denatured krill product is a krill meal.
`
`12. A method of production of krill oil comprising:
`
`a) obtaining a denatured krill product produced by treating freshly harvested krill to denature lipases and
`
`phospholipases in said krill and that has been stored from 1 to 24 months; and
`
`b) extracting oil from said denatured krill product that has been stored from 1 to 24 months with a polar
`
`solvent to provide a krill oil with from about 3% to about 15% ether phospholipids w/w of said krill oil astaxanthin esters in
`
`amount of greater than about 100 mg/kg of said krill oil.
`
`14. The method of claim 12, wherein said denatured krill product is a krill meal.
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0003
`
`

`

`CLAIMS – ‘046 Patent
`
`1. A method of production of krill oil comprising:
`
`obtaining a krill meal produced by a process comprising treating krill to destroy the activity of lipases and
`
`phospholipases naturally present in krill and wherein said krill meal has been stored for period of from 1 to 36 months;
`
`and
`
`extracting krill oil from said krill meal that has been stored from 1 to 36 months with a polar solvent to
`
`provide a krill oil with greater than 30% phosphatidylcholine w/w of said krill oil and astaxanthin esters.
`
`13. A method of production of Euphausia superba krill oil comprising:
`
`a) obtaining a Euphausia superba krill meal produced by a process comprising treating Euphausia superba to
`
`destroy the activity of lipases and phospholipases naturally present in Euphausia superba and wherein said Euphausia
`
`superba krill meal has been stored from 1 to 36 months; and
`
`b) extracting Euphausia superba oil from said krill meal that has been stored from 1 to 36 months with a
`
`polar solvent to provide a Euphausia superba krill oil comprising greater than 30% phosphatidylcholine w/w of
`
`said Euphausia superba krill oil, less than 3% free fatty acids w/w of said Euphausia superba krill oil, and at least 100
`
`mg/kg astaxanthin esters.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0004
`
`

`

`CLAIMS – Key Features
`
`• Starting material: Denatured krill product (which can be krill meal) or krill meal made by
`process which destroys activity of lipases and phospholipases.
`
`• Storing the denatured krill product/krill meal for from 1 to 24 months or 1 to 36 months.
`
`• Extracting krill oil containing phospholipids from the stored krill product/krill meal with a
`polar solvent.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0005
`
`

`

`BREIVIK II IS NOT PRIOR ART
`
`• All of the Grounds rely on Breivik II. If Breivik II is removed, the Grounds fail.
`• The critical date of Breivik II is Nov. 16, 2006 (Ex. 1037 at 0001).
`• Breivik II discloses extraction of a krill oil containing phospholipids from fresh krill that has been
`heat treated immediately prior to extraction. See Ex. 1037, Examples 6 and 7 (p. 0009) and the
`Summary at pp. 0003-4:
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0006
`
`

`

`BREIVIK II IS NOT PRIOR ART – TILSETH DECLARATION
`
`It cannot be disputed that the Dr. Tilseth’s testimony on conception and reduction to practice is corroborated:
`
`• Krill meal was made on board the Atlantic Navigator and stored for 13 months. Ex. 2001 ¶¶ 7-8 (citing Exs.
`2003, 2004, 1001 and 1005).1
`
`• After the storage period, the krill meal was extracted with ethanol. Ex. 2001, ¶¶9-14 (citing Exs. 2005-2014). 1
`
`• The resulting krill oil contained phospholipids including phosphatidylcholine and astaxanthin. Ex. 2001, ¶14
`(citing Exs. 2013, 1001 and 1005). 1
`
`• This method of extraction was developed at least as early as September 14, 2006. Ex. 2001, ¶15. 1
`
`• This evidence demonstrates conception and reduction to practice of at least as much of the invention as the
`reference happens to show.2
`
`• Alternatively, the evidence is sufficient to antedate if the differences are obvious.3
`
`1.
`2.
`3.
`
`PO ‘169/’046 Responses at 20-23, PO ‘169/’046 Sur-Replies at 9-10
`PO ‘169/’046 Responses at 24, citing In re Stempel, In re Wakefield.
`PO ‘169/’046 Responses at 24-25, citing In re Spiller, In re Stryker
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0007
`
`

`

`BREIVIK II IS NOT PRIOR ART – TILSETH DECLARATION
`Exs. 2013 and 2014
`
`PO ‘169/’046 Responses at 22-23.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0008
`
`

`

`BREIVIK II IS NOT PRIOR ART – RULE OF REASON
`
`•
`
`“Sufficiency of corroboration is determined by using a ‘rule of reason’ analysis, under which all pertinent
`evidence is examined when determining the credibility of an inventor’s testimony.” Medichem, S.A. v.
`Rolabo, S.L., 437 F.3d 1157, 1170 (2006).1
`
`• The “rule of reason” was developed to ease the requirement of corroboration. Coleman v. Dines, 754
`F.2d 353, 360 (Fed. Cir. 1985). 1
`
`•
`
`•
`
`“Despite the importance of the independence requirement, however, [t]he law does not impose an
`impossible standard of ‘independence’ on corroborative evidence by requiring that every point of a
`reduction to practice be corroborated by evidence having a source totally independent of the
`inventor....” Medichem, 437 F.3d at 1171. 1
`
`“Credibility concerns undergird the corroboration requirement, the purpose of which is to prevent
`fraud.” Id. Thus, the corroboration requirement provides “a safeguard against courts being deceived by
`inventors who may be tempted to mischaracterize the events of the past through their testimony.” Id. 1
`
`1. PO ‘169/‘046 Sur-Replies at 8-9.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0009
`
`

`

`BREIVIK II IS NOT PRIOR ART – PETITIONER FAILS TO
`APPLY THE RULE OF REASON
`• Petitioner has failed to present any analysis under the “rule of reason.”1
`
`• Instead, Petitioner presents an analysis that focuses on alleged failure to corroborate each claim element
`as written, arguing: “Dr. Tilseth’s post-hoc interpretation of two sections from this 15-year old document
`cannot be used to backfill the gaps in what is not found within the four corners of Sections 6.1-6.2.” 2
`
`• This “four corners” analysis is inconsistent with the “rule of reason.” It is the antithesis of the rule of
`reason to require evidence on every aspect of conception and reduction to practice. E.I. du Pont De
`Nemours & Co., 921 F.3d 1060, 1077 (Fed. Cir. 2019).3
`
`• As a result, Petitioner has failed to present any evidence that undermines the credibility of Dr. Tilseth’s
`testimony.
`
`1.
`2.
`3.
`4.
`
`PO ‘169/’046 Sur-Replies at 15.
`PO ‘169/’046 Sur-Replies at 15-16, (quoting Petitioner’s Reply at 10).
`PO ‘169/-046 Sur-Replies at 16.
`PO ‘169/’046 Sur-Replies at 12.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0010
`
`

`

`BREIVIK II IS NOT PRIOR ART – CREDIBILITY OF DR. TILSETH
`
`• “Credibility concerns undergird the corroboration requirement, the purpose of which is to prevent fraud.”
`Medichem, 437 F.3d at 1171. Thus, the corroboration requirement provides “a safeguard against courts
`being deceived by inventors who may be tempted to mischaracterize the events of the past through their
`testimony.” Id.1
`
`• Has Petitioner done anything to undermine Dr. Tilseth’s credibility? NO!
`
`• First, Petitioner did not depose Dr. Tilseth.2
`
`• Second, Petitioner’s only argument is that that Sections 6.1 and 6.2 of Ex. 2003 does not specifically
`mention that the krill meal was made a standard process involving a cooking stage that denatured krill
`lipases and phospholipases.3
`
`• This argument ignores corroborating evidence presented by Dr. Tilseth and admissions by it’s expert, Dr.
`Tallon.4
`
`1.
`2.
`3.
`4.
`
`PO ‘169/‘046 Sur-Replies at 8.
`PO ‘169/‘046 Sur-Replies at 11. See Paper 14 filed in both IPRs.
`PO ‘169/‘046 Sur-Replies at 12; Petitioner ‘169 /‘046 Replies at 9-10.
`PO ‘169/‘046 Sur-Replies at 12-14
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0011
`
`

`

`BREIVIK II IS NOT PRIOR ART – CREDIBILITY OF DR. TILSETH
`
`• Petitioner focused solely on Sections 6.1 and 6.2 of Ex. 2003 and failed to consider other evidence cited by
`Dr. Tilseth.1
`
`• Dr. Tilseth also testified that the krill meal described in Table 13 of Ex. 2003 is the same meal described in
`Example 1, Table 1 of Ex. 1005 (the priority document). Ex. 2001, ¶8. The data provided in Table 13 of Ex.
`2003 (p. 0023) is repeated in Table 1 of Ex. 1005 (p. 0023).2
`
`• As described in Ex. 1005, the krill meal was made by standard methods (Example 1 at 0023). 3
`
`1.
`2.
`3.
`
`PO ‘169/’046 Sur-Replies at 12.
`PO ‘169/’046 Sur-Replies at 12-14.
`PO ‘169/’046 Sur-Replies at 13.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0012
`
`

`

`BREIVIK II IS NOT PRIOR ART – CREDIBILITY OF DR. TILSETH
`
`• When viewed as a whole, as required by the “rule of reason,” the corroborating evidence supports Dr.
`Tilseth’s testimony that the krill meal was made by a standard process involving cooking, pressing and
`decanting which denatured lipases and phospholipase. Ex. 2001, ¶8.1
`
`• Dr. Tallon acknowledged that the standard process involves cooking sufficient to denature lipases and
`phospholipases.2
`
`• Dr. Tallon, referencing Budziński (Ex. 1008), acknowledged that the “traditional method of krill-meal
`production is by cooking and pressing or centrifuging and drying . . . and the resulting denatured krill meal
`is stable . . . .” Ex. 1006 ¶168.2
`
`• Dr. Tallon confirmed this conclusion in his Reply Declaration: “The cooking that occurs during preparation
`of the krill meal was a well-known process in the prior art for preventing this enzymatic degradation
`allowing for stable storage of a krill meal.” Ex. 1086 ¶46.2
`
`• There is no reasonable basis to believe that Dr. Tilseth somehow manufactured his testimony in a post-hoc
`fashion as alleged by Petitioner.3
`
`1.
`2.
`3.
`
`PO ‘169/’046 Sur-Replies at 15-16.
`PO ‘169/’046 Sur-Replies at 17-18.
`PO ‘169/’046 Sur-Replies at 19.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0013
`
`

`

`BREIVIK II IS NOT PRIOR ART – CORROBORATION WITH
`METADATA
`
`• Petitioner further alleges that Dr. Tilseth has “self-corroborated” Sections 6.1 and 6.2 of Ex. 2003 and that
`Dr. Tilseth’s notes cannot corroborate his reduction to practice story.1
`
`• Metadata has been provided for each of Exs. 2003, 2005, 2008, 2010, and 2013 which provides time
`stamps for the dates on which the documents were created and last modified.2
`
`• The combination of testimony and metadata independently corroborates and authenticates the
`documents. See, e.g., Motorola Mobility LLC. v. Intellectual Ventures II LLC, IPR2014-00504, Paper 84, at
`17-19 (PTAB March 13, 2020)(citing Sonos, Inc. v. Implicit, LLC, 2019 WL 4419356 (PTAB Sept. 16, 2019) and
`ATI Tech. ULC v. Iancu, 920 F.3d 1362, 1370–71 (Fed. Cir. 2019)).2
`
`1.
`2.
`
`Petitioner’s ‘169/’046 Replies 10-11, 14.
`PO ‘169/’046 Sur-Replies at 10, 19-20.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0014
`
`

`

`THE CLAIMS ARE NOT OBVIOUS
`
`• Even if Breivik II is prior art, the claims are not obvious.1
`
`• The claims all require the element of extraction from a denatured krill product or krill meal that has been
`stored for from 1 to 24 or 1 to 36 months.
`
`• The combined references do not teach extraction from any krill material that has been stored for from 1 to
`24 or 1 to 36 months.2
`
`• Alternatively, there is no motivation to combine the references to arrive at a method where krill oil is
`extracted from a denatured krill product or krill meal that has been stored for from 1 to 24 or 1 to 36
`months.3
`
`1.
`2.
`3.
`
`PO ‘169 Response at 36, ‘046 Response at 38.
`PO ‘169 Response at 36-40, ‘046 Response at 44-45.
`PO ‘169 Response at 40-53, ‘046 Response at 45-53.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0015
`
`

`

`THE COMBINED REFERENCES DO NOT TEACH THE ELEMENT
`OF EXTRACTION FROM A STORED MATERIAL
`• Breivik II does not teach extraction from a stored material, and instead teaches extraction from fresh krill.1
`
`• As admitted by Petitioner “Breivik II describes a process in which fresh krill is heated to 80oC, washed with
`ethanol and then subjected to supercritical fluid extraction with CO2 and 10% ethanol to obtain an extract
`“rich in phospholipids” and astaxanthin.” ‘169 Petition at 46, ‘046 Petition at 45.2
`
`• Examples 6 and 7 both describe use of fresh krill that is heated for either five minutes or a few minutes
`immediately before extraction. Ex. 1037 (Breivik II) at 0009.3
`
`• The summary also describes heating immediately before extraction. Ex. 1037 (Breivik II) at 0003-4.4
`
`1.
`2.
`3.
`4.
`
`PO ‘169 Response at 37, ‘046 Response at 42-44. PO ‘169/’046 Sur-Replies at 23-25.
`PO ‘169 Response at 37, ‘046 Response at 42.
`PO ‘169 Sur-Reply at 23, ‘046 Sur-Reply at 26-27.
`PO ‘169 Sur-Reply at 24, ‘046 Sur-Reply at 27.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0016
`
`

`

`THE COMBINED REFERENCES DO NOT TEACH THE ELEMENT
`OF EXTRACTION FROM A STORED MATERIAL
`
`• Budzinski teaches krill meal that is stable for 13 months, but does not teach extraction from that material.1
`• The paragraph at p. 0030 of Budzinski relied on by Petitioner does not disclose extraction from krill meal.1
`• Likewise, the section in Budzinski referring to krill meal does not teach extraction from that meal. Ex. 1008
`at 0027-28.1
`• Dr. Tallon admitted that Budzinski “doesn’t describe much of the detail of how that organic solvent
`extraction might be done.” Ex. 2019 at 0036.1
`
`Budzinski at 0030
`
`Budzinski at 0027-28
`
`1.
`
`PO ‘169 Response at 38-39, ‘046 Response at 39-40
`PO ‘169 Sur-Reply at 27-28, ‘046 Sur-Reply at 22-23.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0017
`
`

`

`THE COMBINED REFERENCES DO NOT TEACH THE ELEMENT
`OF EXTRACTION FROM A STORED MATERIAL
`
`• Neither Fricke 1984 (Ex. 1008) or Fricke 1986 (Ex. 1160) teach extraction from a denatured material that has been
`stored.1
`• Fricke 1984 mentions that samples that were “cooked on board immediately after hauling” had a low free fatty
`acid content.1
`• Fricke 1986, which was belatedly introduced by Petitioner in its Reply, provides no information on storage time
`for cooked krill.1
`
`Fricke 1984 at 0002-3.
`
`1.
`
`PO ‘169 Response at 38, ‘046 Response at 41
`PO ‘169 Sur-Reply at 25-27, ‘046 Sur-Reply at 23-25.
`
`Fricke 1986 at 0001.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0018
`
`

`

`NO MOTIVATION TO COMBINE
`
`• The claims require the step of extracting krill oil from a denatured krill product or krill meal that has been
`stored for from 1 to 24 or 1 to 36 months.
`
`• The lead reference cited in each ground, Breivik II, teaches that fresh krill should be utilized and that its
`methods are suitable for use on-board the fishing vessel at 0003-4.1
`
`1.
`
`PO ‘169 Response at 41, ‘046 Response at 46.
`PO ‘169 Sur-Reply at 29-30, ‘046 Sur-Reply at 26-27.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0019
`
`

`

`NO MOTIVATION TO COMBINE
`
`• Breivik II further specifically notes problems associated with oxidation and polymerization of lipids in
`“traditional krill meal”. Ex. 1037 at 0002, 6, 10, 12.1
`
`Breivik II at 0002.
`
`Breivik II at 0010.
`
`1.
`
`PO ‘169 Response at 41, ‘046 Response at 46.
`PO ‘169/’046 Sur-Replies at 29-30.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0020
`
`

`

`NO MOTIVATION TO COMBINE
`
`• The question becomes whether there is any motivation to substitute a stored krill meal for the fresh krill utilized
`in Breivik II.1
`
`• This motivation does not come from any of the other cited references, none of which teach or suggest extraction
`from a denatured krill product or krill meal that has been stored.2
`
`•
`
`In the absence of any motivation in the references themselves, Petitioner relies on the unsupported testimony of
`Dr. Tallon, arguing: “Among the reasons for extracting krill oil on land as opposed to at sea, include the expense
`of installing and operating extraction processes on a ship, and the hazards associated with using flammable polar
`solvents at sea. Because of the practicality and desirability of preforming land-based solvent extraction, a POSITA
`would have understood that denatured krill needed to be stored prior to extraction because of, inter alia, the
`temporal and geographic restrictions on krill harvesting, the distance between the krill fishing grounds and
`commercial solvent extraction facilities, and the need to intermittently schedule oil extraction to satisfy
`customer demand for freshly extracted krill oil.” ‘169/’046 Petitions at 59-60.3
`
`• No evidence is provided to back up these speculative conclusions other than Dr. Tallon’s unsupported testimony
`which should be given little or no weight.4
`PO ‘169/’046 Sur-Replies at 28-29.
`PO ‘169 Response 41-44, ‘046 Response at 45-49; PO ‘169/’046 Sur-Replies at 28.
`PO ‘169 Response at 41, ‘046 Response at 45-46; PO ‘169/’046 Sur-Replies at 30-31.
`PO ‘169 Response at 45, ‘046 Response at 50; PO ‘169/’046 Sur-Replies at 30-31.
`
`1.
`2.
`3.
`4.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0021
`
`

`

`NO MOTIVATION TO COMBINE
`
`• Dr. Tallon’s deposition testimony undermines the unsupported rationale in his Declaration.1
`
`• When deposed, Dr. Tallon admitted that the flammability of ethanol “did not preclude it from being used
`on a ship” and that “flammable solvents can be managed.” Ex. 2019 at 0049, l. 18 – 25.2
`
`• When deposed, Dr. Tallon further admitted that factories in ships looked just like land-based factories and
`that “conceptually, many of the processes that we have been involved with could equally be installed on a
`ship as they could on land.”3
`
`• There is no basis to conclude that extraction would preferably be done on land on stored material due to
`safety concerns when: a) Breivik II teaches that extraction of fresh krill is preferable and that its processes
`can be performed on the fishing vessel; and b) Dr. Tallon admitted that solvents can be managed on-board
`a ship.4
`
`• Finally, no supporting evidence is provided to support Dr. Tallon’s speculation on economic advantages of
`extracting on land. Ex. 1006 at ¶173.5
`
`1.
`2.
`3.
`4.
`5.
`
`PO ‘169 Response at 42-45, ‘046 Response at 47-51.
`PO ‘169 Response at 42, ‘046 Response at 47.
`PO ‘169 Response at 45, ‘046 Response at 50-51.
`PO ‘169 Response at 43, ‘046 Response at 48.
`PO ‘169 Response at 45 , ‘046 Response at 50.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0022
`
`

`

`CONCLUSION
`
`• Breivik II is not prior art. Dr. Tilseth’s corroborated testimony establishes conception and reduction to
`practice prior to the November 16, 2006 critical date of Breivik II.
`
`• Since all of the Grounds in both IPR’s rely on Breivik II, removal of Breivik II as a prior art reference defeats
`every asserted Ground.
`
`• Even if Breivik II is admitted as prior art, the combined references do not teach the claim element of
`extraction from a denatured krill product or krill meal that has been stored from 1 to 24 or 1 to 36 months.
`
`• Grounds 1 and 2 of IPR2020-01532 should be denied.
`
`• Grounds 1, 2 and 3 of IPR2020-01533 should be denied.
`
`DEMONSTRATIVE EXHIBIT - NOT EVIDENCE
`
`AKER EXHIBIT 2026 SLIDE 0023
`
`

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