`A23L0001-29 [I
`,A]; BOLFOO
`
`A23L0001-326 [
`I,A]; BO1DO
`A23D0007-005 [
`I,A]; A23D0
`A23L0001-29 [I,A]; A23L00
`
`BO1D0021-30 [I,A]; BO1F00
`
`
`
`THIS PATE
`CAS INDEXING IS AVAILABLE FOR
`
`IPCR
`
`
` Natural astaxan
`
`ANSWER 18 OF 27
`2006:254989
`
`
`
`
`
`
`
`15-06 [I,A]; A23L0001-33 [I,A];
`021-30 [I,A]
`007-02 [I,A]; A23D0007-04 [I,A];
`01-326 [I,A]; A23L0001-33 [I1,A];
`15-06 [I,A]
`NT.
`
`
`
`(10)
`
`PCT 371 date
`(60)
`
`USPATFULL on STN
`USPATFULL
`thin extract redu ces dna oxidation
`
`
`
`ED STATES
`WA, UNIT
`Chew, Boon P., Pullman,
`
`
`Park, Jean Soon
`, Pullman,
`WA, UNITED STATES
`Al
`US 20060217445
`20060928
`Al
`US 2004-565717
`20040726
`WO 2004-US24314
`20040726
`20060123
`20030725
`
`L4
`AN
`TI
`IN
`
`PI
`Al
`
`PRAI
`DT
`FS
`LN.CNT
`INCL
`
`NCL
`
`IPC
`
`US 2003-490121P
`
`
`
`
`
`
`
`Utility
`APPLICATION
`1366
`000
`INCLM: 514/690.
`INCLS: 514/763.
`000;
`000
`NCLM:
`514/690.
`514/763.000
`NCLS:
`514/560.
`000;
`IPCI
`A61K0031-12 [1I,A]; A61K00
`A61K0031-12 [1I,A]; A61K00
`IPCR
`
`
`THIS PATE
`BLE FOR
`CAS INDEXING IS AVAILA
`
`514/560.000
`
`31-015 [I,A]
`31-015 [I,A]
`NT.
`
`
`ANSWER 19 OF 27
`2006:227598
`
`USPATFULL on STN
`USPATFULL
`
`
`
`L4
`AN
`TI
`IN
`
`PA
`
`PI
`Al
`
`PRAI
`DT
`FS
`LN.CNT
`INCL
`NCL
`IPC
`
`Preventive or remedy for arthritis
`JAPAN
`Ibaraki,
`Kamiya, Toshikazu,
`
`NC, UNITED STATES
`Nakagiri, Ryusuke,
`Chapel Hill,
`Ltd., Tok
`yo,
`JAPAN, 100-8185 (non-U.S.
`Kyowa Hakko Kogyo Co.,
`corporation)
`US 20060193962
`US 2004-552526
`WO 2004-JP5115
`
`Al
`Al
`
`20060831
`20040409
`20040409
`20051011
`20030411
`
`JP 2003-107405
`
`
`
`
`
`(10)
`
`PCT 371 date
`
`001-14 [I,A]; A23K0001-16 [I,A];
`31-7008 [I,A]; A61K0031-726 [I1,A];
`36-185 [1I,A]; A61P0019-02 [I,A]
`NT.
`
`Utility
`APPLICATION
`1047
`INCLM: 426/615.000
`NCLM:
`426/615.000
`IPCI
`A23L0001-212 [I,A]
`IPCR
`A23L0001-212 [1I,A]; A23K0
`A23L0001-30 [I,A]; A61K00
`A61K0036-00 [I,A]; A61K00
`
`
`
`THIS PATE
`BLE FOR
`CAS INDEXING IS AVAILA
`
`
`
`
`
` Yokoo, Yoshiharu,
`
`L4
`AN
`TI
`IN
`
`PI
`
`Al
`
`PRAI
`DT
`
`r,
`ANSWER 20 OF 27
`2004:209092
`
`USPATFULL on STN
`USPATFULL
`
`Process for producing a plant extract containing plant powder
`AN
`Sakai, Yasushi,
`Tsukuba-shi,
`JAP
`Sagamihara-shi,
`Al
`20040819
`
`B2
`20090421
`Al
`20031219
`20020621
`20010621
`
`JAPAN
`
`(10)
`
`US 20040161524
`US 7521079
`US 2003-481519
`WO 2002-JP6226
`JP 2001-188480
`
`Utility
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0901
`
`page 0901
`
`

`

`IPC
`
`L4
`AN
`TI
`
`IN
`
`PI
`AI
`
`PRAI
`
`APPLICATION
`FS
`LN.CNI 1479
`INCL
`INCLM: 426/655.000
`NCL
`NCLM:
`426/655.000
`NCLS:
`426/433.000; 426/594.000; 426/597.000
`[7]
`A23L0001-28
`IPCI
`IPCI-2 A23L0001-28
`IPCR
`A23L0001-28
`A23L0001-30
`
`
`
`
`
`
`
`Al; A23K0001-14 [I,A]; A23K0001-16 [I1,A];
`
`A]; A61K0036-185 [I,A]
`
`
`
`
`ANSWER 21 OF 27 USPATFULL on STN
`2004:209046
`USPATFULL
`Preventives or remedies for arthritis
`
`JAPAN
`Nakagiri, Rysuke, Tokyo,
`Kamiya, Toshikazu, Tsuchiura-shi,
`Suda, Toshio, Sunto-gun,
`JAPAN
`Miki,
`Ichiro, Mishima-shi,
`JAPAN
`US 20040161478
`Al
`20040819
`US 2003-480044
`Al
`20031209 (10)
`WO 2002-JP5790
`20020611
`JP 2001-181947
`20010615
`JP 2002-70702
`20020314
`
`JAPAN
`
`
`
`Utility
`DT
`APPLICATION
`FS
`LN.CNT 1301
`INCL
`INCLM: 424/725.000
`NCL
`NCLM:
`424/725.000
`IPC
`[7]
`IPCI
`IPCR
`
`A61K0035-78 [I
`A21D0002-36 [I, Al; A21D0013-08 [I,A]; A23K0001-14 [I,A];
`A23K0001-16 [I,A]; A23L0001-30 [I,A]; A61K0036-185 [I1,A];
`A61P0019-02 [I,A]; A61P0029-00 [I,A]
`
`ANSWER 22 OF 27 USPATFULL on STN
`2004:159281
`USPATFULL
`
`
`
`
`
`Liver funcion protecting or ameliorating agent
`Sakai, Yasushi, Tsukuba-shi,
`JAPAN
`Kayahashi, Shun, Tsukuba-shi,
`JAPAN
`
`Hashizume, Erika, Tsukuba-shi,
`JAPAN
`Nakagiri, Ryusuke, Tokyo,
`JAPAN
`US 20040122085
`Al
`20040624
`
`B2
`US 7332522
`20080219
`US 2003-473867
`Al
`20031003 (10)
`WO 2002-JP3098
`20020328
`
`L4
`AN
`
`TI
`IN
`
`PI
`
`AI
`
`IPC
`
`L4
`AN
`
`TI
`
`Utility
`DT
`APPLICATION
`FS
`LN.CNT 1146
`INCL
`INCLM: 514/470.000
`NCL
`NCLM:
`514/457.000; 514/470.000
`NCLS:
`514/470.000; 549/283.000
`[7]
`A61K0031-365 [ICM,7]
`IPCI
`IPCI-2 A61K0031-34 [I,A]; A61K0031-343 [I,A]
`IPCR
`A61K0031-34 [1,A]; A23L0001-30 [I,A]; A61K0031-343 [I1,A];
`A61K0031-365 [1,A]; A61K0031-366 [I,A]; A61P0001-16 [I1,A];
`CQ7D0307-88 [I,A]; CO7D0311-76 [I,A]
`
`
`
`
`CAS INDEXING IS AVAILABLE FOR THIS PATENT.
`
`
`
`
`
`
`USPATFULL on STN
`ANSWER 23 OF 27
`2003:64375 USPATFULL
`
`
`
`Processes for extracting carotenoids and for preparing feed materials
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0902
`
`page 0902
`
`

`

`
`
`ISRAEL
`Kagan, Michael, Jerusalem,
`ISRAEL
`Braun, Sergei, Zur Hadassa,
`Al
`20030306
`
`B2
`20041116
`US 6818239
`Al
`20020617 (10)
`US 2002-172747
`Continuation of Ser. No. WO 2000-IL846, filed on 18 Dec 2000, UNKNOWN
`GB 1999-30194
`19991221
`
`
`
` US 20030044495
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`USPATFULL on STN
`ANSWER 24 OF 27
`2002:205917 USPATFULL
`
`IN
`
`PI
`
`Al
`RLI
`PRAI
`DT
`FS
`LN.CNT
`INCL
`NCL
`
`IPC
`
`L4
`AN
`TI
`IN
`
`PI
`Al
`PRAI
`DT
`FS
`LN.CNT
`INCL
`NCL
`IPC
`
`Utility
`APPLICATION
`526
`INCLM: 426/250.000
`NCLM:
`426/429.000; 426/250.000
`NCLS:
`426/250.000; 426/253.000; 426/431.000; 426/478.000; 426/540.000
`[7]
`[ICM,7]
`A23L0001-27
`IPCI
`[ICM,7]; A23L0001-27 [ICS,7]
`IPCI-2 A23L0001-28
`[I,A]; A23L0001-275 [I,A]; CO7C0403-00 [I1,A];
`IPCR
`A23L0001-27
`[I,A]; CO9B0061-00 [I,A]
`C07C0403-24
`
`
`
`CAS INDEXING IS AVAILABLE FOR THIS PATENT.
`
`Liver function protecting or improving agent
`Nakagiri, Ryusuke, Tsukuba-shi,
`JAPAN
`Kamiya, Toshikazu, Tsukuba-shi,
`JAPAN
`Hashizume, Erika, Tsukuba-shi,
`JAPAN
`Sakai, Yasushi,
`Inashiki-gun,
`JAPAN
`Kayahashi, Shun, Tsukuba-shi,
`JAPAN
`US 20020110605
`Al
`20020815
`US 2001-10154
`Al
`20011210 (10)
`JP 2000-375510
`20001211
`
`
`
`Utility
`APPLICATION
`1786
`INCLM: 424/725.000
`NCLM:
`424/725.000
`[7]
`IPCI
`IPCR
`
`A61K0035-78 [ICM, 7]
`A21D0002-36 [1I,A]; A21D0013-08 [I,A]; A23K0001-14 [I,A];
`A23K0001-16 [1I,A]; A23L0001-212 [I,A]; A23L0001-30 [I,A];
`A61K0036-185 [1,A]; A61P0001-16 [I,A]
`
`
`
`
`CAS INDEXING IS AVAILABLE FOR THIS PATENT.
`
`
`
`USPAT2 on STN
`USPAT2
`
`L4
`AN
`TI
`IN
`
`PA
`PI
`
`Al
`
`PRAI
`DT
`FS
`LN.CNT
`INCL
`
`NCL
`
`ANSWER 25 OF 27
`2004:209092
`
`
`
`Process for producing an extract of Hydrangea containing plant powder
`Sakai, Yasushi, Tsukuba,
`JAPAN
`JAPAN
`Yokoo, Yoshiharu, Sagamihara,
`Kyowa Hakko Kogyo Co., Ltd., Tokyo,
`
`US 7521079
`B2
`20090421
`WO 2003000074
`20030301
`US 2002-481519
`20020621 (10)
`WO 2002-JP6226
`20020621
`20031219
`20010621
`
`JAPAN (non-U.S. corporation)
`
`JP 2001-188480
`
`PCT 371 date
`
`
`
`Utility
`GRANTED
`1371
`INCLM: 426/655.000
`INCLS: 426/594.000; 426/597.000; 426/433.000
`NCLM:
`426/655.000
`NCLS:
`426/433.000; 426/594.000; 426/597.000
`
`
`
`
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0903
`
`page 0903
`
`

`

`IPC
`
`EXF
`
` L4
`
`AN
`
`TI
`IN
`
`PA
`PI
`
`AI
`
`PRAI
`
`A23L0001-28 [ICM,7]
`IPCI
`IPCI-2 A23L0001-28 [I,A]
`IPCR
`A23L0001-28 [1I,A]; A23K0001-14 [I,A]; A23K0001-16 [I1,A];
`A23L0001-30 [I,A]; A61K0036-185 [I,A]
`426/597; 426/433; 426/594
`
`
`
`ANSWER 26 OF 27 USPAT2 on STN
`2004:159281
`USPAT2
`
`
`
`
`
`Liver function protecting or ameliorating agent
`Sakai, Yasushi, Tsukuba,
`JAPAN
`Kayahashi, Shun, Tsukuba,
`JAPAN
`
`Hashizume, Erika, Tsukuba,
`JAPAN
`Nakagiri, Ryusuke, Tokyo,
`JAPAN
`Kyowa Hakko Kogyo Co., Ltd., Tokyo,
`
`B2
`US 7332522
`20080219
`wo 2002080904
`20021017
`US 2002-473867
`20020328 (10)
`WO 2002-JP3098
`20020328
`20031003
`20010405
`
`JAPAN (non-U.S. corporation)
`
`JP 2001-106600
`
`PCT 371 date
`
`Utility
`
`GRANTED
`
`
`
`NCL
`
`IPC
`
`
`
`DT
`FS
`LN.CNTI 1099
`INCL
`INCLM: 514/457.000
`INCLS: 514/470.000; 549/283.000
`NCLM:
`514/457.000; 514/470.000
`NCLS:
`514/470.000; 549/283.000
`IPCI
`A61K0031-365 [ICM,7]
`IPCI-2 A61K0031-34 [I,A]; A61K0031-343 [I,A]
`IPCR
`A61K0031-34 [1I,A]; A23L0001-30 [I,A]; A61K0031-343 [I1,A];
`A61K0031-365 [1,A]; A61K0031-366 [I,A]; A61P0001-16 [I1,A];
`CQ7D0307-88 [I,A]; CO7D0311-76 [I,A]
`549/283; 549/290; 549/307; 549/289; 514/457; 514/470
`EXF
`
`
`
`
`CAS INDEXING IS AVAILABLE FOR THIS PATENT.
`
`
`USPAT2 on STN
`ANSWER 27 OF 27
`2003:64375 USPAT2
`
`
`
`
`
`L4
`AN
`
`TI
`IN
`
`PA
`PI
`AI
`RLI
`PRAI
`
`Processes for extracting carotenoids and for preparing feed materials
`
`
`ISRAEL
`Kagan, Michael, Jerusalem,
`
`ISRAEL
`Braun, Sergei, Zur Hadassa,
`Fermentron Ltd., Jerusalem,
`ISRAEL (non-U.S. corporation)
`
`B2
`US 6818239
`20041116
`US 2002-172747
`20020617 (10)
`Continuation of Ser. No. WO 2000-IL846, filed on 18 Dec 2000
`GB 1999-30194
`19991221
`
`
`
`
`
`
`
`
`
`Utility
`DT
`GRANTED
`FS
`LN.CNT 501
`INCL
`INCLM: 426/429.000
`INCLS: 426/431.000; 426/478.000; 426/250.000; 426/253.000; 426/540.000
`NCLM:
`426/429.000; 426/250.000
`NCLS:
`426/250.000; 426/253.000; 426/431.000; 426/478.000; 426/540.000
`[7]
`A23L0001-27 [ICM,7]
`IPCI
`IPCI-2 A23L0001-28 [ICM,7]; A23L0001-27 [ICS,7]
`IPCR
`A23L0001-27 [I,A]; A23L0001-275 [I,A]; CO7C0403-00 [I1,A];
`C07C0403-24 [I,A]; CO9B0061-00 [I,A]
`426/807; 426/250; 426/253; 426/635; 426/425; 426/429; 426/430; 426/431;
`426/478; 426/540; 424/439; 424/451
`
`
`
`
`
`CAS INDEXING IS AVAILABLE FOR THIS PATENT.
`
`
`
`
`
`NCL
`
`IPC
`
`
`EXF
`
`
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0904
`
`page 0904
`
`

`

`=> d hist
`
`
`
`
`
`
`(FILE 'HOME' ENTERED AT 15:15:33 ON 03 JAN 2012)
`
`
`
`
`
`
`
`
`
`FILE ADISNEWS
`
`FILE ANTE
`
`FILE AQUALINE
`
`FILE BIOENG
`
`
`FILE BIOTECHABS
`
`FILE BIOTECHDS
`FILE BIOTECHNO
`
`
`FILE CEABA-VTB
`
`FILE CIN
`FILE FOMAD
`FILE FROSTI
`
`
`FILE FSTA
`
`FILE IFIPAT
`
`
`FILE KOSMET
`
`FILE NTIS
`
`
`FILE PASCAL
`
`FILE USPATFULL
`
`
`FILE USPAT2
`
`FILE WATER
`FILE WPIDS
`
`FILE WPINDEX
`
`QUE KRILL AND OIL AND
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`INDEX 'ADISCTI, ADISINSIGHT, ADISNEWS, AGRICOLA, ANABSTR, ANTE, AQUALINE,
`
`
`AQUASCI, BIOENG, BIOSIS, BIOTECHABS, BIOTECHDS, BIOTECHNO, CABA, CAPLUS,
`
`
`
`
`CEABA-VTB, CIN, CONFSCI, CROPB, CROPU, DDFB, DDFU, DGENE, DISSABS, DRUGB,
`
`
`
`DRUGU, EMBAL, EMBASE, ESBIOBASE,
`...' ENTERED AT 15:15:47 ON 03 JAN 2012
`
`MEAL AND SUPERCRITICAL (P)EXTRACT? AND SOL
`SEA KRILL AND OIL AND
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`O*
`O*
`0*
`0O*
`O*
`O*
`O*
`0*
`O*
`O*
`O*
`O*
`1
`O*
`O*
`O*
`28
`4
`O*
`1
`1
`
`
`
`
`
`
`
`
`MEAL AND SUPERCRITICAL (P) EXTRACT? AND SOL
`
`
`
`
`FILE 'IFIPAT, USPATFULL, USPAT2' ENTERED AT 15:19:01 ON 03 JAN 2012
`33 S$ Ll
`
`
`(1 DUPLICATE REMOVED)
`32 DUP REM L2
`27 S L3 AND DIOXIDE
`
`L1
`
`L2
`L3
`L4
`
`
`=> logoff
`
`
`
`
`
`
`ALL L# QUERIES AND ANSWER SETS ARE DELETED AT LOGOFE
`LOGOFF?
`(¥)/N/HOLD:y
`COST IN U.S. DOLLARS
`
`
`FULL ESTIMATED COST
`
`
`SIN INTERNATIONAL LOGOFF AT 15:21:58 ON 03 JAN 2012
`
`
`
`
`
`SINCE FILE
`
`ENTRY
`43.57
`
`TOTAL
`
`SESSION
`47.51
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0905
`
`page 0905
`
`

`

`WESTSearchHistory for Application 12057775
`
`Creation Date: 2012010315:00
`
`Prior Art Searches
`
`Thes.
`
`Date
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`01-03-2012
`
`Ss
`
`Ss
`
`Ss
`
`m=
`
`m=
`
`m=
`
`aeesln
`
`aeesln
`
`m=
`
`ES
`
`YES
`
`01-03-2012
`
`YES
`
`01-03-2012
`
`ES
`
`01-03-2012
`
`Se
`
`aeesln 01-03-2012
`
`"krill oil”
`
`(‘krill oil" ) and ''krill meal"
`
`C'krill oil" and "krill meal" ) and
`“supercritical fluid"
`
`extract? and krill and oil and meal and
`supercritical
`
`2004241249
`
`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`082s eee
`
`(20040241249 ) and "supercritical"
`
`(20040241249 ) and "solvent extraction"
`
`(20040041249) and “extract”
`
`(20040241249 and "extract" ) and "oil"
`
`(20040241249 and "extract" and "oil" )
`and 'meal"
`
`PGPB
`
`supercritical and extraction and krill
`
`(supercritical and extraction and krill )
`and co-solvent
`
`(supercritical and extraction andkrill
`and co-solvent ) and oil
`
`supercritical and extraction and alcohol
`
`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`WESTSearch History for Application 12057775
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0906
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`1
`page 0906
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`

`

`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`PGPB, USPT, USOC,
`EPAB, JPAB, DWPI,
`TDBD
`
`01-03-2012
`
`EPAB, JPAB, DWPI,
`
`ae
`
`(supercritical and extraction and alcohol
`) and monohydric
`
`(supercritical and extraction and alcohol
`and monohydric ) and krill and meal
`
`PGPB, USPT, USOC,
`
`YES
`
`01-03-2012
`
`TDBD
`
`Prior Art Searches
`
`RIMFROST EXHIBIT 1024
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`RIMFROST EXHIBIT 1024 page 0907
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`2
`page 0907
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`

`

`12057775 - GAlbidBO)
`Receiptdate: 03/08/2011
`Approvedfor use through 07/31/2012. OMB 0651-0031
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`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
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`
`Application Number
`12057775
`
`
`Filing Date
`2008-03-28
`
`
`INFORMATION DISCLOSURE
`First Named Inventor|Inge Bruheim, etal.
`
`STATEMENT BY APPLICANT
`( Not for submission under 37 CFR 1.99)
`
`Art Unit
`
`| 1651
`
`Examiner Name
`
`Susan Marie Hanley
`
`Attorney Docket Number
`
`| NATNUT-14409/US-5/ORD
`
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`Examiner] Cite|Foreign Document Kind|Publication Applicant of citedCountry where Relevant Ts
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`
`
`Initial* No|Number? Code2 j Code4| Date PP Passages or Relevant
`
`Document
`.
`Figures Appear
`
`
`NIPPON SUISAN
`[|
`KAISHA, LTD.
`2000-05-11
`WO
`2000/25608
`1
`
`
`2|2000/38708 2000-07-06|ARSON MEDICALWo Ol
`
`
`
`
`
`
`
`
`
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`
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`3
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`2002/102394
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`WO
`
`2002-12-27
`
`NEPTUNE
`TECHNOLOGIES &
`BIORESS
`
`[|
`
`EFS Web 2.1.17
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`ALL REFERENCES CONSIDERED EXOUMFROSE REHIRAD024 RMase P9080. W_/
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`
`Receipt date: 03/08/2011
`
`12057775 12057775 - GAU: 1651
`Application Number
`2008-03-28
`Filing Date
`First Named Inventor
`Inge Bruhein, et al.
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`( Not for submission under 37 CFR 1.99)
`
`Art Unit
`
`| 1651
`
`Examiner Name
`
` Susan Marie Hanley Attorney Docket Number
`BIORESSOURCES INC.
`|lpm
`pew
`
`+lpene
`pfpr
`
`fev
`+fewer
`
`
`
`
`
`
`
`
`| NATNUT-14409/US-5/ORD
`
`2003-02-13
`
`NEPTUNE
`TECHNOLOGIES &
`
`2005-01-13
`
`KONIN-KLIJKE PHILIPS
`ELECTRONICSNLV.
`
`2005-04-28
`
`ENZYMOTEC LTD.
`
`2005-04-28
`
`ENZYMOTECINC.
`
`2007-07-19
`
`KRILL A/S
`
`2007-07-19
`
`AKER BIOMARINE ASA
`
`2007/108702
`
`2007-09-27
`
`AKER SEAFOODS
`HOLDING AS
`
`2008/006607
`
`2008-01-17
`
`NATTOPHARMA ASA
`
`2008/117062
`
`2008-10-02
`
`AKER BIOMARINE ASA
`
`2009/027692
`
`2009-03-05
`
`AKER BIOMARINE ASA
`
`2001/028526
`
`2001-04-26
`
`TRUFFINI & REGGE
`FARMACEUTICI
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`Receipt date: 03/08/2011
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`
`
`12057775 12057775 - GAU: 1651
`Application Number
`
`2008-03-28
`Filing Date
`
`
`First Named Inventor Inge Bruhein, et al.
`| 1651
`
`Art Unit
`
`Examiner Name
`
`| NATNUT-14409/US-5/ORD
`
`INFORMATION DISCLOSURE
`STATEMENT BY APPLICANT
`( Not for submission under 37 CFR 1.99)
`
`2004/047554
`
`2004-06-10
`
`PHARES PHARM RES
`NV
`
`
`
`1.B.R ISRAELI
`
`
`RESEARCH LTD.
`
`16|0973532 EP 2005-09-07 BIOTECHNOLOGY
`
` Susan Marie Hanley Attorney Docket Number
`
`
`
`
`
`
`
`
`
`UNIVERSITE DE
`
`SHERBROOKE
`
`17=|1123368 EP 2008-04-09
`
`
`
`
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`18=|1292294 EP 2009-03-18
`
`
`ACCERA, INC.
`
`
`
`2001/082928
`
`2001-11-08
`
`2003/013497
`
`2003-02-20
`
`21
`
`1419768
`
`EP
`
`2009-01-07
`
`HENDERSON
`
`SUNTORYLIMITED
`
`NEPTUNE
`TECHNOLOGIES &
`BIORESSOURCES, INC.
`
`22|1385506 EP 2010-07-28 DEVELOPMENT CO.
`
`YEDA RESEARCH AND
`
`
`LTD
`
`
`
`
`
`2002/083122
`
`2002-10-24
`
`2004-03-03
`
`2002/092540
`
`2002-11-21
`
`YEDA RESEARCH AND
`DEVELOPMENT CO.
`LTD
`
`MARTEK BIOSCIENCES
`BOULDER
`CORPORATION
`
`MARTEK BIOSCIENCES
`BOULDER
`CORPORATION
`
`EFS Web 2.1.17
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`

`

`
`
`
`Receipt date: 03/08/2011
`Application Number
`12057775
`12057775 - GAU: 1651
`
`
`Filing Date
`2008-03-28
`
`INFORMATION DISCLOSURE
`
`First Named Inventor|Inge Bruheim, etal.
`STATEMENT BY APPLICANT
`( Not for submission under 37 CFR 1.99)
`
`Art Unit
`
`Examiner Name
`
`| 1651
`
`Susan Marie Hanley
`
`Attorney Docket Number
`
`| NATNUT-14409/US-5/ORD
`
`
`
`NEPTUNE
`26 2009-01-07|TECHNOLOGIES &1406641
`BIORESSOURCES, INC.
`
`
`
`
`
`2005/070411 2005-08-04|BRUZ7ESE
`
`Identical to
`
`2005-06-22.|SUNTORY LIMITED WO2004023529
`
`
`
`2004/028529 2004-04-08|SUNTORY LIMITED
`
`
`
`EP
`
`EP
`
`30
`
`1743531
`
`31
`
`1631286
`
`2004/100943
`
`2005/018632
`
`2007-01-17
`
`NIPPON SUISAN
`KAISHA, LTD
`
`2008-03-08
`
`BTG INTERNATIONAL
`LIMITED
`
`2004-11-25
`
`2006-05-31
`
`2005-03-03
`
`BTG INTERNATIONAL
`LIMITED
`
`BTG INTERNATIONAL
`LIMITED
`
`BTG INTERNATIONAL
`LIMITED
`
`
`
`2006/030552 2006-03-23|SUNTORY LIMITED
`
`
`
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`
`
`
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`
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`36 2006-08-16|ENZYMOTEC LTD.1689413 EP
`
`EFS Web 2.1.17
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`ALL REFERENCES CONSIDERED EXOUMFROSE REHIRAD024 R@ase PPLID.W./
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`RIMFROST EXHIBIT 1024 page 0911
`
`
`
`

`

`
`
`Receipt date: 03/08/2011
`
`Application Number
`12057775
`12057775 - GAU: 1651
`
`
`Filing Date
`2008-03-28
`
`
`
`
`. — ed— —_
`
`
`
`
`
`
`
`INFORMATION DISCLOSURE
`
`First Named Inventor|Inge Bruheim, etal.
`STATEMENT BY APPLICANT
`( Not for submission under 37 CFR 1.99)
`
`Art Unit
`
`| 1651
`
`Examiner Name
`
`Susan Marie Hanley
`
`Attorney Docket Number
`
`| NATNUT-14409/US-5/ORD
`
`If you wish to add additional Foreign Patent Documentcitation information please click the Add button
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`NON-PATENT LITERATURE DOCUMENTS
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`
`Include nameof the author (in CAPITAL LETTERS},title of the article (when appropriate), title of the item
`Examiner] Cite
`TS
`(book, magazine, journal, serial, symposium, catalog, etc}, date, pages(s), volume-issue number(s),
`Initials*|No
`
`publisher, city and/or country where published.
`
`TAKAICHI et al., 2003, “Fatty Acids of astaxanthin estersin krill determined by mild mass spectrometry’, Comparative
`[|
`Biochemistry and Physiology Part B, Biochemistry and Molecular Biology, Elsevier, Oxford, Vol. 136, 1 January 2003,
`1
`p. 317-322;
`
`
`Ol
`TANAKA et al., 2004, “Extraction of Phospholipids from Salmon Roe with Supercritical Carbon Dioxide and an
`2
`Entrainer’, J. Oleo Sci, 53(9): 417-424
`
`
`Ol
`TANAKA et al., 2005, “Extraction of Phospholipids from Unused Natrual Resources with Supercritical Carbon Dioxide
`3
`and an Entrainer’, Journal of Oleo Science, Vol. 54(11}: 569-576
`
`
`Ol
`TODORICet al., 2006, “Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by
`4
`n-3 polyunsaturated fatty acids”, Diabetologia, 49(9): 2109-2119
`
`
`TOU et al., 2007, “Krill for human consumption: nutritional value and potential health benefits.”, Nutrition Rev 65
`[|
`5
`(2):63-77
`
`
`Ol
`TRAYHURNet al., 2004, “Adipokines: inflammation and the pleiotropic role of white adipose tissue”, Br. J. Nutrition,
`6
`92(3): 347-355
`
`
`TREBBLE etal., 2003, “Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclearcells
`[|
`following dietary fish-oil supplementation in healthy men and responseto antioxidant co-supplementation”, Br. J.
`7
`Nutrition, $0{2): 405-412
`
`
`UKKOLAet al., 2002, “Adiponectin: a link between excess adiposity and associated comorbidities?”, J. Mol. Med., 80
`(11): 696-702
`
`Ol
`
`EFS Web 2.1.17
`
`ALL REFERENCES CONSIDERED EXOUMFROSE REHIRAD024 R@ase 09120. W./
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`RIMFROST EXHIBIT 1024 page 0912
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`

`

`
`
`
`
`Receipt date: 03/08/2011
`
`Application Number
`12057775
`12057775 - GAU: 1651
`
`
`Filing Date
`2008-03-28
`
`
`
`
`
`
`INFORMATION DISCLOSURE
`
`First Named Inventor|Inge Bruheim, etal.
`STATEMENT BY APPLICANT
`( Not for submission under 37 CFR 1.99)
`
`Art Unit
`
`| 1651
`
`Examiner Name
`
`Susan Marie Hanley
`
`Attorney Docket Number
`
`| NATNUT-14409/US-5/ORD
`
`VAN DER VEEN et al., 1971 “The Lipids of Krill (Euphausia Species) and Red Crab (Pleuroncodes Planipes)”, Lipids,
`6(7): 481-485
`
`VIRTUE, et al. 1996, Reproductive trade-off in male Antarctic krill, Euphausia superba”, Marine Biology, Volume 126,
`Number3, Pages 521-527
`
`YAMAGUCHI et al., 1983, “The Composition of Carotenoid Pigments in the Antarctic Krill Euphausia superba”, Bulletin
`of the Japanese Society of Scientific Fisheries, 49(9): 1411-1415
`
`YAMAGUCHI et al., 1986, “Supercritical Carbon Dioxide Extraction Of Oils From Antarctic Krill,” Journal Of Agricultural
`And Food Chemistry, vol. 34, pp. 904-907
`
`YANASE M; 1974, “Modification of a Russian method for separation of heat-coagulated protein from Antarctic krill’,
`Database FSTA (online); International Food Information Service (IFIS} FRANKFURT-MAIN, DE
`
`YEN etal., 1994, “Effect of dietary omega-3 and omega-6 fatty acid sources on PUVA-induced cutaneous toxicity and
`tumorogenesis in the hairless mouse”, Arch. Dermatol. Res., 286(6): 331-6
`
`DATABASE WPI Week 200682, Thomson Scientific, London, GB, 2006
`
`ENGLISH ABSTRACT; JP 2003-531857; See abstract from corresponding WO 2001/082928 filed herewith
`
`ENGLISH ABSTRACT; JP 2004-525180; See abstract from corresponding WO 2002/0831 22 filed herewith
`
`ENGLISH ABSTRACT; JP 2006-528233; See abstract from corresponding WO 2004/100943filed herewith
`
`ENGLISH ABSTRACT; JP 2007-502805; See abstract from corresponding WO 2005/0186372filed herewith
`
`EFS Web 2.1.17
`
`ALL REFERENCES CONSIDERED EXOUMFROSE REHIRED024 R@ase PP130.W./
`
`RIMFROST EXHIBIT 1024 page 0913
`
`

`

`
`Receipt date: 03/08/2011
`Application Number
`12057775
`12057775 - GAU: 1651
`
`Filing Date
`2008-03-28
`
`
`INFORMATION DISCLOSURE
`First Named Inventor|Inge Bruheim, etal.
`
`STATEMENT BY APPLICANT
`( Not for submission under 37 CFR 1.99)
`
`Art Unit
`
`Examiner Name
`
`| 1651
`
`
`
`
`
`Susan Marie Hanley Attorney Docket Number
`
`
`
`| NATNUT-14409/US-5/ORD
`
`ENGLISH ABSTRACT; JP 2007-509131; See abstract from corresponding WO 2005/037848filed herewith
`
`ENGLISH ABSTRACT; JP 2007-518764; See abstract from corresponding WO 2005/070411 filed herewith
`
`ENGLISH ABSTRACT; JP 2004-536059; See abstract from corresponding WO 2002/09254 filed herewith
`
`ENGLISH ABSTRACT; JP 2006-502196; See abstract from corresponding WO 2004/028529filed herewith
`
`If you wish to add additional non-patentliterature documentcitation information please click the Add button
`
`Examiner Signature
`
`
`Deborah Ware/
`Date Considered
`
`L2/30/11
`
`*EXAMINER:Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through a
`citation if not in conformance and not considered.
`Include copy of this form with next communication to applicant.
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`Standard ST.3). * For Japanese patent documents,the indication of the year of the reign of the Emperor must precede the serial number of the patent document.
`4 Kind of document by the appropriate symbols as indicated on the document under WIPO Standard ST.16 if possible.
`° Applicant is to place a check mark here if]
`English language translation is attached.
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`EFS Web 2.1.17
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`RIMFROST EXHIBIT 1024 page 0914
`
`

`

`
`Application/Control No.
`Applicant(s)/Patent Under
`Reexamination
`BRUHEIM ET AL.
`
`Search Notes
`
`12057775
`
`Examiner
`
`DEBBIE K WARE
`
`Art Unit
`
`1651
`
`SEARCHED
`
`SEARCH NOTES
`
`Search Notes|Date||Examiner_|
`WEST, NPL and INV: see searchhistory print out
`
`
`
`
`
`12/2011-1/2012
`
`
`U.S. Patent and Trademark Office
`RIMFROST EXHIBES O24 no. page20915
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`RIMFROST EXHIBIT 1024 page 0915
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`

`

`Application/Control No.
`
`Index of Claims
`
`12057775
`
`Applicant(s)/Patent Under
`Reexamination
`BRUHEIM ET AL.
`
`Examiner
`
`DEBBIE K WARE
`
`
`
`Rejected = Cancelled
`2 Allowed +|Restricted
`
`
`
`(1 ‘Claims renumberedin the sameorder as presented by applicant
`
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`
`O T.D.
`
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`
`Part of Paper No.
`
`: 20111230
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0916
`
`page 0916
`
`

`

`Application/Control No.
`
`Index of Claims
`
`12057775
`
`Applicant(s)/Patent Under
`Reexamination
`BRUHEIM ET AL.
`
`Examiner
`
`DEBBIE K WARE
`
`Rejected
`
`2 Allowed
`
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`Part of Paper No.
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`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0917
`
`page 0917
`
`

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`Application/Control No.
`
`Index of Claims
`
`12057775
`
`Applicant(s)/Patent Under
`Reexamination
`BRUHEIM ET AL.
`
`Examiner
`
`DEBBIE K WARE
`
`Rejected
`
`2 Allowed
`
`CLAIM
`
`Zz
`
`U.S. Patent and Trademark Office
`
`Part of Paper No.
`
`: 20111230
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0918
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`page 0918
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`

`

`PATENT
`Attorney Docket No.: NATNUT-14409/US-5/ORD
`
`IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
`
`Art Unit: 1651
`In re Application of: Bruheim etal.
`Examiner: Ware
`Serial No.:
`12/057,775
`Confirmation: 1945
`Filed:
`March 28, 2008
`Entitled:
`BIOEFFECTIVE KRIL OIL COMPOSITIONS
`
`RESPONSE TO RESTRICTION REQUIREMENT
`MAILED SEPTEMBER8,2011
`
`EFS WEB FILED
`Commissionerfor Patents
`P.O. Box 1450
`Alexandria, Virginia 22313-1450
`
`Examiner Ware:
`
`This communication is responsive to the Office Action mailed September 8, 2011. The
`
`Commissioneris hereby authorized to charge any fees during the entire pendencyofthis
`
`application, including fees due under 37 C.F.R. §§ 1.16 and 1.17 that may be required, including
`
`any required extension of time fees, or credit any overpayment to Deposit Account 50-4302,
`
`referencing Attorney Docket No. NATNUT-14409/US-5/ORD. This paragraphis intended to
`
`be a CONSTRUCTIVE PETITION FOR EXTENSION OF TIMEin accordance with 37 C.F.R.
`
`§ 1.136(a)(3).
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0919
`
`page 0919
`
`

`

`PATENT
`Attorney Docket No.: NATNUT-14409/US-5/ORD
`
`IN THE CLAIMS
`
`1.
`
`(Withdrawn) A composition comprising:
`
`from about 3% to 10% ether phospholipids on a w/w basis;
`
`from about 35% to 50% non-ether phospholipids on w/w basis, so that the total amount of
`
`ether phospholipids and non-ether phospholipids in the composition is from about 48% to 60%
`
`on a w/w basis;
`
`from about 20% to 45% triglycerides on a w/w basis;
`
`and from about 400 to about 2500 mg/kg astaxanthin.
`
`2.
`
`(Withdrawn) The composition of Claim 1, wherein said ether phospholipids are selected
`
`from the group consisting of alkylacylphosphatidylcholine, lyso-alkylacylphosphatidylcholine,
`
`alkylacylphosphatidylethanolamine, and combinationsthereof.
`
`3.
`
`(Withdrawn) The composition of Claim 1, wherein said etherlipids are greater than 90%
`
`alkylacylphosphatidylcholine.
`
`4.
`
`(Withdrawn) The composition of Claim 1, wherein said non-ether phospholipids are
`
`selected from the group consisting of phosphatidylcholine, phosphatidylserine,
`
`phosphatidylethanolamine and combinationsthereof.
`
`5.
`
`(Withdrawn) The composition of Claim 1, wherein said composition comprises a blend
`
`oflipid fractions obtained from Euphausia superba.
`
`6.
`
`(Withdrawn) The composition of Claim 1, wherein said composition comprises from
`
`about 25% to 30% omega-3 fatty acids as a percentage of total fatty acids and wherein from
`
`about 80% to 90% of said omega-3 fatty acids are attached to said phospholipids.
`
`7.
`
`(Withdrawn) A capsule containing the composition of Claim 1.
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0920
`
`page 0920
`
`

`

`PATENT
`Attorney Docket No.: NATNUT-14409/US-5/ORD
`
`8.
`
`(Withdrawn) A composition comprising:
`
`from about 3% to 10% ether phospholipids on a w/w basis; and
`
`from about 400 to about 2500 mg/kg astaxanthin.
`
`9.
`
`(Withdrawn) The composition of Claim 8, further comprising from about 35% to 50%
`
`non-ether phospholipids on w/w basis, so that the total amount of ether phospholipids and non-
`
`ether phospholipids in the composition is from about 38% to 60% on a w/w basis.
`
`10.
`
`(Withdrawn) The composition of Claim 8, further comprising from about 20% to 45%
`
`triglycerides on a w/w basis.
`
`11.
`
`(Withdrawn) The composition of Claim 8, wherein said ether phospholipids are selected
`
`from the group consisting of alkylacylphosphatidylcholine, lyso-alkylacylphosphatidylcholine,
`
`alkylacylphosphatidylethanolamine, and combinationsthereof.
`
`12.
`
`(Withdrawn) The composition of Claim 11, wherein said ether lipids are greater than
`
`90% alkylacylphosphatidylcholine.
`
`13.
`
`(Withdrawn) The composition of Claim 8, wherein said non-ether phospholipids are
`
`selected from the group consisting of phosphatidylcholine, phosphatidylserine,
`
`phosphatidylethanolamine and combinationsthereof.
`
`14.
`
`(Withdrawn) The composition of Claim 8, wherein said composition comprises a blend
`
`oflipid fractions obtained from Euphausia superba.
`
`15.
`
`(Withdrawn) The composition of Claim 10, wherein said composition comprises from
`
`about 25% to 30% omega-3 fatty acids as a percentage of total fatty acids and wherein from
`
`about 80% to 90% of said omega-3 fatty acids are attached to said phospholipids.
`
`16.
`
`(Withdrawn) A capsule containing the composition of Claim 8.
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0921
`
`page 0921
`
`

`

`PATENT
`Attorney Docket No.: NATNUT-14409/US-5/ORD
`
`17.
`
`(Withdrawn) A blended krill oil composition comprising:
`
`from about 45% to 55% w/w phospholipids;
`
`from about 20% to 45% w/w triglycerides;
`
`and from about 400 to about 2500 mg/kg astaxanthin.
`
`18.
`
`(Withdrawn) The composition of Claim 17, wherein said blended krill oil product
`
`comprises a blendoflipid fractions obtained from Euphausia superba.
`
`19.
`
`(Withdrawn) The composition of Claim 17, wherein said composition comprises from
`
`about 25% to 30% omega-3 fatty acids as a percentage of total fatty acids and wherein from
`
`about 80% to 90% of said omega-3 fatty acids are attached to said phospholipids.
`
`20.
`
`(Withdrawn) A Euphausia superba krill oil composition comprising:
`
`from about 3% to about 10% w/w ether phospholipids;
`
`from about 27% to 50% w/w non-ether phospholipids so that the amount of total
`
`phospholipids in the composition is from about 30% to 60% w/w;
`
`from about 20% to 50% w/w triglycerides;
`
`from about 400 to about 2500 mg/kg astaxanthin; and
`
`from about 20% to 35% omega-3 fatty acids as a percentage oftotal fatty acids in said
`
`composition, wherein from about 70% to 95% of said omega-3 fatty acids are attached to said
`
`phospholipids.
`
`21.
`
`(Withdrawn) A dietary supplement comprising encapsulated Euphausia superba krill oil
`
`comprising from about 3% to about 10% w/w ether phospholipids; from about 27% to 50% w/w
`
`non-ether phospholipids so that the amount of total phospholipids in the composition is from
`
`about 30% to 60% w/w; from about 20% to 50% w/w triglycerides; from about 400 to about
`
`2500 mg/kg astaxanthin; and from about 20% to 35% omega-3 fatty acids as a percentage of
`
`total fatty acids in said composition, wherein from about 70% to 95% of said omega-3 fatty acids
`
`are attached to said phospholipids.
`
`RIMFROST EXHIBIT 1024
`
`RIMFROST EXHIBIT 1024 page 0922
`
`page 0922
`
`

`

`PATENT
`Attorney Docket No.: NATNUT-14409/US-5/ORD
`
`22.
`
`(Withdrawn) A method of making a Euphausia superba krill oil composition comprising:
`
`contacting Euphausia superba with a polar solvent to provide a polar extract comprising
`
`phospholipids;
`
`contacting Euphasia superba with a neutral solvent
`
`to provide a neutral extract
`
`comprising triglycerides and astaxanthin;
`
`combining said polar extract and said neutral extract to provide Euphausia superba krill
`
`oil from about 3% to about 10% w/w ether phospholipids; from about 27% to 50% w/w non-
`
`ether phospholipids so that the amountof total phospholipids in the composition is from about
`
`30% to 60% w/w; from about 20% to 50% w/w triglycerides; from about 400 to about 2500
`
`mg/kg astaxanthin; and from about 20% to 35% omega-3 fatty acids as a percentage oftotal fatty
`
`acids in said composition, wherein from about 70% to 95% of said omega-3 fatty acids are
`
`attached to said phospholipids.
`
`23.
`
`(Withdrawn) The method of Claim 22, further comprising the step of encapsulating the
`
`Euphausia superba krill oil.
`
`24.
`
`(Withdrawn) A Euphausia super