https://www.youtube.com/watch?v=ukQwAceNzPc
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`Page 1
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`IPR2020-001343
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`Medtronic Ex-1824
`Medtronic v. Teleflex
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`

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`Page 1
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` VIDEO/AUDIO FILE TRANSCRIPTION
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` GuideLiner V3 Catheter: The Engineering Story
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`www.veritext.com
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`888-391-3376
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`Veritext Legal Solutions
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`IPR2020-01343
`
`Medtronic Ex-1824
`Medtronic v. Teleflex
`
`

`

`Page 2
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`1 The story of Guideliner is kind of the
`2 story of innovation.
`3 So back in 2009, the GuideLiner was the
`4 first guide extension catheter introduced into the
`5 market.
`6 The unmet clinical need was for a guide
`7 catheter extension that provided backup where it was
`8 needed most. We recognized that there was a need for a
`9 product that really allowed physicians to deliver more
`10 gear into more complex lesions through tighter vessels or
`11 tortuosity and further distal into the anatomy.
`12 One of the things that the GuideLiner was
`13 designed to do was to provide stability and support for
`14 the guide catheter to provide additional backup and allow
`15 you a solid basis of operations from which to conduct
`16 your procedure.
`17 With the invention of the GuideLiner, it
`18 gave us the ability to place a guide catheter distal
`19 shaft into the coronary vasculature which alleviated
`20 delivery issues. Once physicians got their hands on it
`21 and started to see what the clinical utility was and how
`22 many applications they could use this catheter for, it
`23 started to become the go-to catheter.
`24 Because it gives you that confidence and
`25 that stability as a basis of operation, you can continue
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`Page 4
`1 find a coating that allowed the catheter to deliver into
`2 that distal anatomy, but then also provided the backup
`3 support. The silicone coating provides enough lubricity
`4 for movement, but it also allows the device to stay put
`5 in the guide when you want it to stay put.
`6 Our bench tests show an 18 to 46 percent
`7 increase in GuideLiner V3 catheter backup support,
`8 compared to competitive guide catheters with fully
`9 hydrophilic coated guide extensions.
`10 If you look at metal support options for
`11 catheters, you're kind of left with two viable options,
`12 and that's realistically a coil-reinforced design or a
`13 braid reinforced design.
`14 We decided for the GuideLiner that the
`15 choice was obvious to go with a coil. We came to the
`16 conclusion right away that a braided design does not hold
`17 its shape very well. In our bench testing, around a 7
`18 and a half millimeter bend, a braided guide extension
`19 catheter construction will give up 10 percent of its
`20 diameter versus the coiled guide extension catheter does
`21 not give up any of its diameter.
`22 Our testing also found that the stiffer
`23 distal shaft of a competitive coiled guide extension
`24 catheter will give up 7 percent of its diameter versus
`25 the GuideLiner V3 catheter's coiled distal shaft, which
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`Page 3
`1 to focus on delivering your devices where they need to
`2 go.
`3 And that really pushed us to continue to
`4 innovate that design. So it went from a simple metal
`5 collar design to a simple polymer collar design to what
`6 is now our current GuideLiner V3 that features a
`7 half-pipe that really does help with device delivery
`8 interactions. It really helps align those devices and
`9 get those delivered easier into the GuideLiner V3 and
`10 into that distal anatomy.
`11 The half-pipe design on the GuideLiner V3
`12 catheter represents our commitment to continuous
`13 improvement and continuous engineering and innovation on
`14 our products.
`15 The engineering process is almost always
`16 the art of compromise. How feature rich do we make the
`17 device versus how simple and how small, how low profile.
`18 And that kind of gets back to the flexibility,
`19 deliverability, pushability of the GuideLiner catheter.
`20 You can put an extremely lubricious
`21 hydrophilic coating on a GuideLiner catheter, and it
`22 delivers amazingly. But the problem is you have no
`23 backup support. And it really comes down to laws of
`24 motion and physics.
`25 And so we really had to compromise and
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`Page 5
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`1 does not give up any of its diameter.
`2 In the coronary anatomy, you are
`3 delivering the collar up and over the aortic arch. And
`4 so we realized that if we could move that collar back to
`5 a straighter section of the aorta, that you're going to
`6 have better luck delivering that device.
`7 What that does is reduces the wire wrap of
`8 the wire within the guide catheter into the guide
`9 extension. It reduces the interactions of interventional
`10 devices with the collar of the guide extension.
`11 The GuideLiner V3 catheter features a
`12 17-centimeter polymer bond between the extension and the
`13 push wire to minimize device separation. And we've sold
`14 over a half a million GuideLiner V3 catheters, and we've
`15 yet to have a collar separation in coronary PCI.
`16 When we talk about effective ID, what
`17 we've really talking about is what's the smallest point
`18 from the hemostasis valve all the way to the distal tip
`19 of the guide catheter. And in most guide extension
`20 catheters, the smallest area is in the guide catheter
`21 with the pushrod.
`22 So when we were looking at the GuideLiner
`23 catheter, we decided we wanted to use a
`24 rectangular-shaped ribbon wire. What that gets us is
`25 additional space within the guide catheter to deliver
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`www.veritext.com
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`Veritext Legal Solutions
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`2 (Pages 2 - 5)
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`888-391-3376
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`Page 3
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`IPR2020-01343
`
`Medtronic Ex-1824
`Medtronic v. Teleflex
`
`

`

`Page 6
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`Page 8
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`1 REPORTER'S CERTIFICATE
`2 STATE OF MINNESOTA )
` ) ss.
`3 COUNTY OF HENNEPIN )
`4 I, Dawn Workman Bounds, hereby certify that I
`reported the above audio transcription to the best of my
`5 ability on the 17th day of December, 2020, in
`Minneapolis, Minnesota.
`
`6
`
` That the cost of the original has been charged
`7 to the party who noticed the transcription, and that all
`parties who ordered copies have been charged at the same
`8 rate for such copies;
`9 That I am not a relative or employee or
`attorney or counsel of any of the parties, or a relative
`10 or employee of such attorney or counsel;
`11 That I am not financially interested in the
`action and have no contract with the parties, attorneys,
`12 or persons with an interest in the action that affects or
`has a substantial tendency to affect my impartiality;
`
`13
`
` I further assert that the transcript may
`14 contain unintelligible or inaudible portions that were
`indecipherable to me and beyond my control.
`
`15
`16 WITNESS MY HAND AND SEAL THIS 18th day of
`December, 2020.
`
`17
`18
`19
`20
`21 <%17934,Signature%>
` Dawn Workman Bounds
`22 Notary Public, Hennepin County, Minnesota
` My commission expires January 31, 2024
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`23
`24
`25
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`1 interventional devices. It allows you to deliver more
`2 gear, larger gear, through your guide catheter, through
`3 the guide extension, and to the target lesion.
`4 We're 56 thousandths from the moment you
`5 enter the guide catheter to the moment you exit the
`6 distal tip. When you look at some of our competitors,
`7 they chose to do a round pushrod. They're giving up, you
`8 know, 5 to 6 thousandths in that guide catheter. The
`9 design differences can seem small. In the end, that
`10 makes a huge difference on whether or not your case is
`11 successful. 5 or 6 thousandths in effective ID, that's a
`12 big number.
`13 When you're talking about backup support,
`14 18 to 46 percent more backup support with a GuideLiner is
`15 a huge number. In the last 10 years, across the
`16 generations of GuideLiner catheters, we've sold more than
`17 a million catheters worldwide, and we've solidified our
`18 place as a market leader in guide extension.
`19 And I think in the last 10 years, we've
`20 seen a tremendous shift in the complexity of cases that
`21 are able to be treated due to the technology of
`22 GuideLiner. Whether those are, you know, longer lesions,
`23 more tortuous lesions, more calcium, you know, the
`24 GuideLiner is really a necessary tool for those.
`25 It represents the commitment to solving
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`Page 7
`1 unmet clinical needs. That's really what we've done with
`2 the GuideLiner catheter is, is created a solution and
`3 created a market. We understand the clinical impacts and
`4 the procedural impacts of guide extension, and we've
`5 continued to improve our catheter to make sure that we
`6 address those issues.
`7 Physicians choose GuideLiner on a daily
`8 basis because they just know that when they pull a
`9 GuideLiner, it's going to work.
`10 (End of video/audio file.)
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`www.veritext.com
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`Veritext Legal Solutions
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`3 (Pages 6 - 8)
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`888-391-3376
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`Page 4
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`IPR2020-01343
`
`Medtronic Ex-1824
`Medtronic v. Teleflex
`
`

`

`[10 - engineering]
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`1
`10 4:19 6:15,19
`17 5:12
`17934 8:21
`17th 8:5
`18 4:6 6:14
`18th 8:16
`2
`2009 2:3
`2020 8:5,16
`2024 8:22
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`a
`ability 2:18 8:5
`able 6:21
`action 8:11,12
`additional 2:14
`5:25
`address 7:6
`affect 8:12
`align 3:8
`alleviated 2:19
`allow 2:14
`allowed 2:9 4:1
`allows 4:4 6:1
`amazingly 3:22
`anatomy 2:11 3:10
`4:2 5:2
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`www.veritext.com
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`aorta 5:5
`aortic 5:3
`applications 2:22
`arch 5:3
`area 5:20
`art 3:16
`assert 8:13
`attorney 8:9,10
`attorneys 8:11
`audio 1:14 7:10
`8:4
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`b
`back 2:3 3:18 5:4
`backup 2:7,14
`3:23 4:2,7 6:13,14
`basis 2:15,25 7:8
`bench 4:6,17
`bend 4:18
`best 8:4
`better 5:6
`beyond 8:14
`big 6:12
`bond 5:12
`bounds 8:4,21
`braid 4:13
`braided 4:16,18
`c
`calcium 6:23
`case 6:10
`cases 6:20
`catheter 1:15 2:4,7
`2:14,18,22,23 3:12
`3:19,21 4:1,7,19
`4:20,24 5:8,11,19
`5:20,23,25 6:2,5,8
`7:2,5
`catheter's 4:25
`catheters 4:8,11
`5:14,20 6:16,17
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`centimeter 5:12
`certificate 8:1
`certify 8:4
`charged 8:6,7
`choice 4:15
`choose 7:7
`chose 6:7
`clinical 2:6,21 7:1
`7:3
`coated 4:9
`coating 3:21 4:1,3
`coil 4:12,15
`coiled 4:20,23,25
`collar 3:5,5 5:3,4
`5:10,15
`comes 3:23
`commission 8:22
`commitment 3:12
`6:25
`compared 4:8
`competitive 4:8,23
`competitors 6:6
`complex 2:10
`complexity 6:20
`compromise 3:16
`3:25
`conclusion 4:16
`conduct 2:15
`confidence 2:24
`construction 4:19
`contain 8:14
`continue 2:25 3:3
`continued 7:5
`continuous 3:12
`3:13
`contract 8:11
`control 8:14
`copies 8:7,8
`coronary 2:19 5:2
`5:15
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`Veritext Legal Solutions
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`cost 8:6
`counsel 8:9,10
`county 8:3,22
`created 7:2,3
`current 3:6
`d
`daily 7:7
`dawn 8:4,21
`day 8:5,16
`december 8:5,16
`decided 4:14 5:23
`deliver 2:9 4:1
`5:25 6:1
`deliverability 3:19
`delivered 3:9
`delivering 3:1 5:3
`5:6
`delivers 3:22
`delivery 2:20 3:7
`design 3:4,5,5,11
`4:12,13,16 6:9
`designed 2:13
`device 3:7,17 4:4
`5:6,13
`devices 3:1,8 5:10
`6:1
`diameter 4:20,21
`4:24 5:1
`difference 6:10
`differences 6:9
`distal 2:11,18 3:10
`4:2,23,25 5:18 6:6
`due 6:21
`e
`easier 3:9
`effective 5:16 6:11
`employee 8:9,10
`engineering 1:15
`3:13,15
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`888-391-3376
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`Page 5
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`IPR2020-01343
`
`Medtronic Ex-1824
`Medtronic v. Teleflex
`
`

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`[enter - pushrod]
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`Page 2
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`enter 6:5
`exit 6:5
`expires 8:22
`extension 2:4,7
`4:18,20,23 5:9,10
`5:12,19 6:3,18 7:4
`extensions 4:9
`extremely 3:20
`f
`feature 3:16
`features 3:6 5:11
`file 1:14 7:10
`financially 8:11
`find 4:1
`first 2:4
`flexibility 3:18
`focus 3:1
`found 4:22
`fully 4:8
`further 2:11 8:13
`g
`gear 2:10 6:2,2
`generations 6:16
`give 4:19,21,24 5:1
`gives 2:24
`giving 6:7
`go 2:23 3:2 4:15
`going 5:5 7:9
`guide 2:4,6,14,18
`4:5,8,9,18,20,23
`5:8,8,10,19,19,20
`5:25 6:2,3,5,8,18
`7:4
`guideliner 1:15
`2:1,3,12,17 3:6,9
`3:11,19,21 4:7,14
`4:25 5:11,14,22
`6:14,16,22,24 7:2
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`h
`half 3:7,11 4:18
`5:14
`hand 8:16
`hands 2:20
`help 3:7
`helps 3:8
`hemostasis 5:18
`hennepin 8:3,22
`hold 4:16
`huge 6:10,15
`hydrophilic 3:21
`4:9
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`i
`impacts 7:3,4
`impartiality 8:12
`improve 7:5
`improvement 3:13
`inaudible 8:14
`increase 4:7
`indecipherable
`8:14
`innovate 3:4
`innovation 2:2
`3:13
`interactions 3:8
`5:9
`interest 8:12
`interested 8:11
`interventional 5:9
`6:1
`introduced 2:4
`invention 2:17
`issues 2:20 7:6
`j
`january 8:22
`k
`kind 2:1 3:18 4:11
`know 6:8,22,23
`7:8
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`l
`larger 6:2
`laws 3:23
`leader 6:18
`left 4:11
`lesion 6:3
`lesions 2:10 6:22
`6:23
`longer 6:22
`look 4:10 6:6
`looking 5:22
`low 3:17
`lubricious 3:20
`lubricity 4:3
`luck 5:6
`m
`market 2:5 6:18
`7:3
`metal 3:4 4:10
`millimeter 4:18
`million 5:14 6:17
`minimize 5:13
`minneapolis 8:5
`minnesota 8:2,5
`8:22
`moment 6:4,5
`motion 3:24
`move 5:4
`movement 4:4
`n
`necessary 6:24
`need 2:6,8 3:1
`needed 2:8
`needs 7:1
`notary 8:22
`noticed 8:7
`number 6:12,15
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`o
`obvious 4:15
`once 2:20
`operation 2:25
`operations 2:15
`options 4:10,11
`ordered 8:7
`original 8:6
`p
`parties 8:7,9,11
`party 8:7
`pci 5:15
`percent 4:6,19,24
`6:14
`persons 8:12
`physicians 2:9,20
`7:7
`physics 3:24
`pipe 3:7,11
`place 2:18 6:18
`point 5:17
`polymer 3:5 5:12
`portions 8:14
`problem 3:22
`procedural 7:4
`procedure 2:16
`process 3:15
`product 2:9
`products 3:14
`profile 3:17
`provide 2:13,14
`provided 2:7 4:2
`provides 4:3
`public 8:22
`pull 7:8
`push 5:13
`pushability 3:19
`pushed 3:3
`pushrod 5:21 6:7
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`Page 6
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`IPR2020-01343
`
`Medtronic Ex-1824
`Medtronic v. Teleflex
`
`

`

`[put - years]
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`u
`understand 7:3
`unintelligible 8:14
`unmet 2:6 7:1
`use 2:22 5:23
`utility 2:21
`v
`v3 1:15 3:6,9,11
`4:7,25 5:11,14
`valve 5:18
`vasculature 2:19
`versus 3:17 4:20
`4:24
`vessels 2:10
`viable 4:11
`video 1:14 7:10
`w
`want 4:5
`wanted 5:23
`way 5:18
`we've 5:13,14,17
`6:16,17,19 7:1,4
`went 3:4
`wire 5:7,8,13,24
`witness 8:16
`work 7:9
`workman 8:4,21
`worldwide 6:17
`wrap 5:7
`y
`years 6:15,19
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`put 3:20 4:4,5
`r
`
`rate 8:8
`realistically 4:12
`realized 5:4
`really 2:9 3:3,7,8
`3:23,25 5:17 6:24
`7:1
`recognized 2:8
`rectangular 5:24
`reduces 5:7,9
`reinforced 4:12,13
`relative 8:9,9
`reported 8:4
`reporter's 8:1
`represents 3:12
`6:25
`ribbon 5:24
`rich 3:16
`right 4:16
`round 6:7
`s
`seal 8:16
`section 5:5
`see 2:21
`seen 6:20
`separation 5:13,15
`shaft 2:19 4:23,25
`shape 4:17
`shaped 5:24
`shift 6:20
`show 4:6
`signature 8:21
`silicone 4:3
`simple 3:4,5,17
`small 3:17 6:9
`smallest 5:17,20
`sold 5:13 6:16
`solid 2:15
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`solidified 6:17
`solution 7:2
`solving 6:25
`space 5:25
`ss 8:2
`stability 2:13,25
`started 2:21,23
`state 8:2
`stay 4:4,5
`stiffer 4:22
`story 1:15 2:1,2
`straighter 5:5
`substantial 8:12
`successful 6:11
`support 2:13 3:23
`4:3,7,10 6:13,14
`sure 7:5
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`t
`talk 5:16
`talking 5:17 6:13
`target 6:3
`technology 6:21
`tendency 8:12
`testing 4:17,22
`tests 4:6
`things 2:12
`think 6:19
`thousandths 6:4,8
`6:11
`tighter 2:10
`tip 5:18 6:6
`tool 6:24
`tortuosity 2:11
`tortuous 6:23
`transcript 8:13
`transcription 1:14
`8:4,7
`treated 6:21
`tremendous 6:20
`two 4:11
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`Page 7
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`IPR2020-01343
`
`Medtronic Ex-1824
`Medtronic v. Teleflex
`
`