Health TechnologyAssessment 2000; Vol. 4: No. 23
`
`TABLE 44 included RCTs: stems vs PTCA ((3er 7 design. quality and execution
`
`Study acronym Multicentre? Method of randomisation
`or author
`
`Description of
`withdrawals and dropouts?
`
`jadad score
`
`GRAMI' "’
`
`FRESCO'”
`
`ESCOBARm
`
`”ismI25
`
`PAMl-Stentm
`
`PSAAMI'H
`
`STENTIM um
`
`Yes
`
`No
`
`No
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Not. stated
`
`Sealed envelope
`
`Closed envelope
`
`Not stated
`
`Not stated
`
`Not stated
`
`By computer
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`No
`
`No
`
`Yes
`
`2
`
`3
`
`3
`
`2
`
`I
`
`I
`
`3
`
`Page 125
`
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`Page 125
`
`Medtronic Exhibit 1014
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`

`

`Appendix 5
`
`«ma
`
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`
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`
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`
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`
`Medtronic Exhi
`
`it 1014
`
`II2
`
`Page 126
`
`Page 126
`
`Medtronic Exhibit 1014
`
`

`

`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
`
`TABLE 46 Incfuded RCTs: stems vs PTCA ((3er 7 short-term event rates and I'e-fntervenfian
`
`Study acronym Procedure
`or author
`
`Event rate
`
`Wk
`
`11
`
`%
`
`NR
`
`I'
`9*
`
`I .3
`IZB
`
`NR
`
`4
`9
`
`4‘
`Ia‘
`
`NR
`
`5.0
`I10
`
`0.9
`3.6
`
`CABG
`
`PTCA
`
`%
`
`I .9
`3.3
`
`0
`0
`
`0.9
`0
`
`n
`
`I
`2
`
`0
`{I
`
`I
`0
`
`NR
`
`NR
`
`NR
`
`95»
`
`o
`5.7
`
`I .3
`IZB
`
`o
`4.3
`
`n
`
`o
`3
`
`I”
`9"
`
`o
`5
`
`NR
`
`NR
`
`NR
`
`96
`
`3.3
`I 9.2
`
`5.0
`I 3.3
`
`n
`
`2‘
`I 0*
`
`NR
`
`NR
`
`4“
`I 3*
`
`NR
`
`NR
`
`GRAMI'”
`
`FRESCO'”
`
`ESCOBAR'Z“
`
`PASTAI25
`
`PAM 551mm
`
`PSIMIVII'27
`
`STENTIM II'“
`
`Stem:
`PTCA
`
`Stem:
`F’TCA
`
`Stem:
`PTCA
`
`Stem:
`PTCA
`
`Stem:
`PTCA
`
`Stent
`F’TCA
`
`Stem:
`PTCA
`
`*p < 0.05, stem compared with PTCA
`
`5
`5
`
`5.0
`5.5
`
`5
`6
`
`5.0
`5.4
`
`0
`{I
`
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`
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`6
`
`5.0
`5.4
`
`Page 127
`
`Medtronic Exhibit 1014
`
`II3
`
`Page 127
`
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`
`

`

`Appendix 5
`
`Mice—mun?—(UFL
`
`
`Enn-_.._“Hum...u.CWu.“
`
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`
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`
`II4
`
`Page 128
`
`a=
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`
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`
`Medtronic Exhi
`
`it 1014
`
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`
`Medtronic Exhibit 1014
`
`

`

`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
`
`xzx:mm2fl2fl=
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`
`Page 129
`
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`
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`

`

`Appendix 5
`
`TABLE 49 Included RCTs:stents vs PTCA forAMl — medium-term event rates and rte-intervention
`
`Study acronym Procedure
`or author
`
`Event rate
`
`I)
`
`96
`
`GRAMI'”
`
`FRESCO'23
`
`ESCOBAR'“
`
`PASTA '25
`
`PAMI-Stentm’
`
`PSAAMI'“
`
`STENTIM II'18
`
`Stem:
`PTCA
`
`Stenc
`PTCA
`
`Stent
`PTCA
`
`Stem:
`PTCA
`
`Stem:
`PTCA
`
`Stenc
`PTCA
`
`Stem:
`F’TCA
`
`NR
`
`I 0’
`24"
`
`6“
`23“
`
`I 4’
`32“
`
`NR
`
`—
`—
`
`I 9
`30
`
`I 3.3
`32.0
`
`5
`20
`
`20.9
`46.4
`
`25’
`6I’
`
`I 8.8
`21.3
`
`*p < 0.05, stem compared with PTCA
`
`TVR
`
`n
`
`96
`
`NR
`
`6.?
`5‘“
`I9“ 25.3
`
`4’
`I9‘
`
`36
`I65
`
`NR
`
`28
`62
`
`NR
`
`6.2
`I19
`
`CABG
`
`PT CA
`
`%
`
`0
`2.?
`
`n
`
`NR
`
`0
`2
`
`NR
`
`NR
`
`NR
`
`NR
`
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`
`NR
`
`NR
`
`NR
`
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`
`I?
`29
`
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`26.4
`
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`0
`
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`0
`
`I53
`I6“
`29“ 26.4
`
`II6
`
`Page 130
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`

`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
`
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`
`Page 131
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`

`Appendix 5
`
`TABLE SI
`
`Included RCTs:stents vs PTCA forAMI — long-term event rates and re-I'ntervenrion
`
`Study acronym Procedure
`or author
`
`Event rate
`
`TVR
`
`CA BG
`
`PT CA
`
`In
`
`9’
`I 8’
`
`I 5’
`34"
`
`20
`3|
`
`96
`
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`34.6
`
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`49.3
`
`I 9.8
`28.2
`
`GRAMI'”
`
`PASTA'”
`
`STENTIM II'”
`
`Stem:
`PTCA
`
`Stenc
`PTCA
`
`Stent
`PTCA
`
`‘p < 0.05, stem compared with PTCA
`
`96
`
`I15
`I92
`
`7
`ID
`
`NR
`
`%
`
`n
`
`NR
`
`NR
`
`NP.
`
`NR
`
`I8
`3|
`
`I18
`28.2
`
`I
`I
`
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`0.9
`
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`I?
`30 27.3
`
`Page 132
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`

`

`Health TechnologyAssessment 2000; Vol. 4: No. 23
`
`Appendix 6
`
`PTCA costs
`
`TABLE 52 PTCAxost of procedure oniy
`
`Reference
`
`Source
`
`Procedure Estimated cost Date
`range (£)
`
`Potential problems with source
`
`jackson er 01.
`Cost-
`effectiveness of
`coronaryr arteryr
`m
`SIEI'IIS
`
`Hospital in
`North West
`Region
`
`?E|ective
`
`H153
`
`l996—l997
`
`Initial procedure resource costs oniyr
`
`Palmer et ai'”
`
`Edinburgh
`
`?Elective
`
`i234 (so. [249)
`
`(publ. I998) Consecutive series oi PTCA in one
`centre, but includes stenting in 42% cases
`
`Wessex DEC
`Report No. 93.
`LMW helziarinsln
`
`Hospital in
`S. of England
`
`Emergency
`
`2955
`
`I998
`
`Figures for procedure (not HRG). Figures
`obtained in I998. but not clear to which
`financial year They relate. (Also not clear
`whether they include stent cost.)
`
`Elective
`
`I76?
`
`Figures out of date (I993—I994)
`
`RITA trial,
`non-London
`Hospital
`
`Elective
`
`2060
`
`I999
`
`I993—I994 figures compounded for
`inflation to |998—|999 using annual 96
`increases for hospital and community
`health services pay and prices index. This
`does not reflect experience since I994 as
`costs have not increased at the index rate
`
`New 1999
`NHS Reference
`Costsm
`
`From all
`249 NHS
`Trusts
`
`Elective
`
`2673
`680—4944
`
`I999
`
`Haywood et all“ Hospital in
`53W Region
`
`iElective
`
`2684
`
`(publ. I999) Current contract price at one centre.
`?From l993i'l999 financial year.What the
`price includes is not specified
`
`Cotton et ai.‘35
`
`E
`
`iElective
`
`4200
`
`(publ. I999} No definition of cost
`
`Page 133
`
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`

`

`Appendix 6
`
`TABLE 53 PTCA: hospital costs
`
`Reference Source
`
`Procedure
`
`Estimated cost Date
`range (£)
`
`Potential problems with source
`
`McKenna
`er aim
`
`4 cardiology
`centres in
`London. N
`Eng. and Scot.
`
`Elective initial
`including L05
`
`235?
`2 I 95—2566
`
`Elective repeat
`including LoS
`
`2929
`2527—3666
`
`l9951'l996 Micro-costing study using current costs
`(publ. I997)
`for l995ll99e. Includes all procedures.
`staff time. laboratory tests and
`medications. Includes comparison of
`micro-costing cost and ECR for the
`four cardiology centres
`
`McKenna
`er al'“
`
`l3 major UK
`cardiac centres
`
`2780
`EEIective
`(standardlsimple) 2024—3995
`
`|995l|996
`(publ. I997)
`
`Results of a survey for ECR prices in
`financial year I995—l996
`
`3 of the
`centres
`
`iElective
`(complex)
`
`403T
`3852—4260
`
`Gave separate prices for complex as
`|995l|996
`(publ. I997) opposed to simple PTCA. No definition
`of complex given
`
`Acute care
`|997l98
`
`Wessex
`DEC report
`No. 93. LMW
`heparinsI32
`
`Elective and
`emergency
`(including L05}
`
`4075
`2075—4325
`2075
`| ”5—4325
`
`|997l|993
`
`ESSENCE trial
`
`iEIective
`including LoS
`
`2523
`
`?Date
`
`Based on I996—I997 figure. Range is
`25—75131 centilesa Costs not wholly
`representative of hospitals diroughout
`The UK. Covers approx 60% of all acute
`hospital episodes from GB (not NI}
`
`Unclear whed'ler cost elective or
`includes LoS. Data taken from
`unpublished PhD thesis
`
`Elective PTCA
`without stent
`
`| I25—2907
`
`South and
`Wessex
`DEC report West Region
`No. 3?.
`Coronary
`artery
`stentsm
`
`West
`Midlands
`DEC report
`No. 9.
`Coronary
`artery
`stents'
`
`Wessex
`DEC report
`No. 93.
`LMW
`heparins'32
`
`Hospital in
`West Midlands
`
`Elective
`including LoS
`
`Emergency
`including L05
`
`Hospital in
`south of
`England
`
`Elective
`
`Emergency
`
`RITA trial,
`Non-
`London
`Hospital
`
`Elective
`including L05
`
`Elective
`including LoS
`
`2623
`
`2?60
`
`2486
`
`2673
`
`3024
`
`3526
`
`il996l|997 Costs from m hospitals‘ consultants
`(cardiologists). It was assumed that
`costs included hospital stay and anti-
`platelet treatment. lFrom |996l|997
`financial year. Do not correlate with
`hospital‘s finance departments
`
`I997
`
`I998
`
`DHA tariffs Figures obtained July I997
`then compounded for inflation using
`annual 95 increase in retail prices index
`for I998. Assumed to also include
`equipment costs
`
`Based on HRGs (EIS and E04} —
`unclear how derived, since mean LoS is
`2.3I42 daysl Figures obtained in I993
`but unclear whether for I997—l993 or
`|998—|999 financial year
`
`I993—I994
`
`Figures out of date
`
`l993—I999
`
`l993—l994 figures compounded for
`inflation to I998—I999 using annual 96
`increases for hospital and community
`health services pay and prices index.
`This does not reflect experience since
`I994 as costs have not increased at
`the index rate
`
`'20
`
`L05, length ofstay
`
`Page 134
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`

`Health TechnologyAssessment 2000; Vol. 4: No. 23
`
`TABLE 54 PTCA: wider costs
`
`Reference
`
`Source
`
`Procedure
`
`Estimated cost
`
`Date
`
`Potential problems with source
`
`range (£)
`
`2683
`
`I 99%| 997
`
`Elective and
`emergency
`
`Figures relate to two financial years
`covering the period li'9fl996 to
`3 ll?! I997: covers all events over initial
`procedure and follow up of 6 months
`
`Hospital in
`North West
`
`Jackson
`at al. Cost-
`effectiveness Region
`of coronary
`artery
`stents ”"
`
`Hospital in
`\Msst Midlands
`
`Elective
`including LoS
`
`3630
`
`I998
`(publ. I998}
`
`Includes costs for all events over initial
`procedure and follow-up of | year.
`Based on follow-up data from
`BENESTENT II trial
`
`West
`Midlands
`
`DEC report
`No. 9.
`Coronary
`artery
`stents'
`
`Page 135
`
`Medtronic Exhibit 1014
`
`I2|
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`

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`

`Health TechnologyAssessment 2000; Vol. 4: No. 23
`
`Appendix 7
`
`Stents costs
`
`TABLE 55 Stem: cost of procedure only
`
`Reference Source
`
`Procedure
`
`Estimated cost Date
`range (£)
`
`Potential problems with source
`
`Cotton
`et all“
`
`lEIective
`
`4200 + 500
`
`(publ. I999) No definition of cost Presumes cost of
`stenting is cost oi the stent itself plus
`cost of PTCA procedure
`
`TABLE 56 Scents: hospital costs
`
`Reference Source
`
`Procedure
`
`Estimated cost Date
`range (E)
`
`Potential problems with source
`
`McKenna
`et al.'3'
`
`Elective repeat
`4 cardiology
`PTCA with
`tantra in
`London, North stent including
`of England
`LoS
`and Scotland
`
`“44
`322 |—5 I23
`
`I995i|996 Micro-costing study using current costs
`(publ. I997)
`for |995i I 9%. Includes all procedures.
`staff time, laboratory tests and
`medications
`
`3 of l3 major
`cardiac centres
`in UK
`
`Elective
`
`3874—46l4 +
`cost of stent
`
`I995i|996
`(publ. I99?)
`
`Results of a survey for ECP. prices in
`financial year l995—l996
`
`Emergency
`
`3574
`
`Wessex
`DEC report
`No. 3?.
`Coronary
`arteryr
`stents'33
`
`West
`Midlands
`DEC report
`No. 9.
`Coronary
`artery
`stencs'
`
`South and
`\Mest Region
`
`Elective
`
`2664—4232
`
`I996I'l99i'r
`
`Costs from two hospimls' consultants
`(cardiologists). It was assumed that
`costs included hospital stay and anti-
`platelet treatment. ?From I996ll997
`financial year: Do not correlate with
`hospital‘s finance departments
`
`Hospital in
`\Msst Midlands
`
`Single. elective
`including LoS
`
`Single.
`emergency
`including L05
`
`4054
`
`4754
`
`I998
`(publ. I998}
`
`DHA tariffs. Figures obmined july I99?
`then compounded for inflation using
`annual % increase in retail prices index
`for I998. Assumed to also include
`equipment costs
`
`Hospital in
`West Midlands
`
`Double, elective 4803
`including LoS
`
`I998
`(publ. I998)
`
`5693‘r
`
`Double.
`emergency
`
`including LoS
`
`DHA tariffs. Figures obtained July I99?
`then compounded for inflation using
`annual 5‘5 increase in retail prices index
`for I998. Assumed to also include
`equipment costs
`
`I23
`
`Page 137
`
`Medtronic Exhibit 1014
`
`Page 137
`
`Medtronic Exhibit 1014
`
`

`

`Appendix 7
`
`TABLE 57 Stents: wider costs
`
`Reference Source
`
`Procedure
`
`Estimated cost Date
`range (£)
`
`Potential problems with source
`
`Elective and
`emergency
`
`36?5
`
`I996i9?
`
`Figures relate to two financial years
`covering the period |i9il996 to
`3|!7il997: covers all events over initial
`procedure and follow up of 6 months
`
`Initial procedure resource costs only
`
`Includes costs for all events over initial
`I998
`(publ. I993) procedure and follow-up of I year.
`Based on follow-up data from
`BENESTENT II trial
`
`Hospital in
`jackson
`et of. Cost- North West
`effectiveness Region
`of coronary
`artery
`ste no;I 3"
`
`West
`Midlands
`DEC report
`No. 9.
`Coronary
`artery
`stents'
`
`3E|ective
`
`2484
`
`4549
`
`Hospital in
`West Midlands
`
`Single, elective
`including LoS
`
`Double. elective 5290
`including LoS
`
`TABLE 58 Stem prices
`
`Company
`Biotronik
`
`Boston Scientific
`
`List price
`
`Not given
`
`NIR {limo—{I440 (median {I 200)
`Wallstent E l 200
`
`Jomed
`
`Not given
`
`Sorin Biomedica
`
`Carbostent £650 + VAT
`
`Selling priceiother information
`Data on file
`
`Data on file
`
`Data on file
`
`No information
`
`I24
`
`Page 138
`
`Medtronic Exhibit 1014
`
`Page 138
`
`Medtronic Exhibit 1014
`
`

`

`Health TechnologyAssessment 2000; Vol. 4: No. 23
`
`Appendix 8
`
`CABG costs
`
`TABLE 59 CABG: cost ofprocedure only
`
`Reference Source
`
`Procedure
`
`Hospital in
`south of
`England
`
`Emergency
`including LoS
`
`Wessex
`DEC report
`No. 93.
`LMW
`heparinsI 31
`
`Estimated cost Date
`range (£)
`
`594i
`
`I998
`
`RITA trial,
`non-London
`Hospital
`
`Elective
`
`Elective
`
`2|05
`
`2454
`
`I998
`
`Potential problems with source
`
`Figures for procedure (not HRG).
`Figures obtained in I998, but not clear
`which financial year they relate to.
`(Also not clear whether they include
`stem: cost.)
`
`I993—I994 figures compounded for
`inflation to I998—I999 using annual 93
`increases for hospital and community
`health services pay and prices index.
`This does not reflect experience since
`I994 as costs have not increased at
`the index mte
`
`From all
`249 N HS
`Truse;
`
`Hospital in
`South and
`VVESC Region
`
`New NHS
`Reference
`Costs
`H995"
`
`Haywood
`et at“
`
`Cotton
`et all“
`
`iEIective
`
`6|05
`2196—9 | 23
`
`I999
`
`Elective
`
`Emergency
`
`iEIective
`
`5905
`
`9000
`
`5500
`
`(publ. I999) Current contract price at one centre.
`From I993r|999 financial yeacWhat
`the price includes is not specified
`
`(publ. I999) No definition of cost
`
`Page 139
`
`Medtronic Exhibit 1014
`
`I25
`
`Page 139
`
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`
`

`

`Appendix 8
`
`TABLE 60 CABG: hospital costs
`
`Reference Source
`
`Procedure
`
`Estimated cost Date
`range (it)
`
`Potential problems with source
`
`McKenna
`et aLm
`
`1! cardiology
`centres in
`London.
`North of
`England and
`Scotland
`
`Elective
`including L05
`
`5539
`3298—7283
`
`5 I79
`Emergency
`following PTCA SARI—7083
`including LoS
`
`I995:r I996 Micro-costing study using current costs
`(publ. I997)
`for I995:r I996. Includes all procedures,
`staff time. hboratory tests and
`medications. Includes comparison of
`micro-costing cost and ECR for the four
`cardiology centres
`
`I3 major
`cardiac centres
`in UK
`
`Elective
`(standard!
`routine)
`
`6502
`4255—8250
`
`I995i‘l996
`(publ. I99?)
`
`Results of a survey for ECR prices in
`financial year I995—l996
`
`6 of the
`centres
`
`826B
`i'EIective
`(complexirepeati 6?55—|0.?1i’0
`emergency}
`
`Gave separate prices for complex as
`I995i‘l996
`{pubL I99?) opposed to simple PTCA. No definition
`of complex given
`
`Wessex
`DEC report
`No. 93.
`LMW
`heparinsI32
`
`West
`Midlands
`DEC report
`No. 9.
`Coronary
`artery
`stents'
`
`Wessex
`DEC report
`No. 93.
`LMW
`heparins'32
`
`Acute care
`I99i‘it I998
`
`Elective
`including LoS
`
`7650
`5875—8I50
`
`I996—I997
`
`ESSENCE trial
`
`Emergency
`including LoS
`iElective
`including LoS
`
`7650
`5600—8375
`4?05
`
`Hospital in
`West Midlands
`
`Elective
`including LoS
`
`Emergency
`including L05
`
`4825
`
`643[
`
`PDate
`
`I996
`(publ. I998)
`
`Elective
`including LoS
`
`3 '97
`
`I996
`
`Hospital in
`south of
`England
`
`RITA trial.
`non-London
`Hospital
`
`Elective
`including LoS
`
`Elective
`including L05
`
`5?22
`
`6672
`
`Based on I996—I997 figure. Range is
`25—75d1 centiles. Costs not wholly
`representative of hospitals throughout
`the UK. Covers approx 60% of all acute
`hospital episodes from GB (not NI)
`Unclear whether cost elective or
`includes LoS. Data taken from
`unpublished PhD thesis
`
`DHA tariffs. Figures obtained July I997
`then compounded for inflation using
`annual 36 increase in retail prices index
`for |998.Assumed to also include
`equipment costs
`
`Based on HRGs (EIS and E04) — unclear
`how derived. since mean LoS is 2.3 |—
`4.2 days. Figures obtained in I998 but
`unclear whether for I997—I993 or
`I998—l999 financial year
`
`Figures out of date (I993—I994)
`
`I998—I999
`
`I993—I994 figures compounded for
`inflation to I998—I999 using annual 95
`increases for hospital and community
`health services pay and prices index.
`This does not reflect experience since
`I994 as costs have not increased at
`the index rate
`
`TABLE 6! CABG: wider costs
`
`Reference Source
`
`Procedure
`
`Estimated cost Date
`range (a!)
`
`Potential problems with source
`
`West
`Midlands
`DEC report
`No 9.
`Coronary
`artery stents|
`
`I26
`
`Hospital in
`West Midlands
`
`Elective
`including LoS
`
`5065
`
`Includes costs for all events over initial
`I998
`(publ. I998) procedure and follow—up of I year.
`Based on follow-up data from meta-
`analyses of CABG vs PTCA
`
`Page 140
`
`Medtronic Exhibit 1014
`
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`
`Medtronic Exhibit 1014
`
`

`

`Health TechnologyAssessment 2000; Vol. 4: No. 23
`
`Appendix 9
`
`Study types of economic analyses
`
`TABLE 62 Summary ofstudy types in economic analyses
`
`Economic analysis
`
`Type of study
`
`RCT
`
`Observationa! study Model
`
`Cost-effectiveness analysis
`
`Cost—utility analysis
`
`BENESTENT ll27
`Serruys at at.
`(V5 CABG for MVD)m
`
`jackson et aim
`
`Costs and outcomes
`reported separately
`
`OPUS'”
`
`MVD, muttivessef coronary disease
`
`Peterson 61 all“
`Palmer et aim
`Farshid et all“
`Kurbaan et all“
`
`Van Hour at all“
`SHPIC at at.”
`Schwicker & Banzm'm
`
`Van Hout at aim“
`Cohen 8: Sukin, [997
`and [999”?2”?
`Wessex DEC'33
`West Midlands DEC'
`Guidantl‘s
`Boston Scientific'50
`
`Page 141
`
`Medtronic Exhibit 1014
`
`I27
`
`Page 141
`
`Medtronic Exhibit 1014
`
`

`

`Page 142
`
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`
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`
`

`

`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
`
`Appendix I 0
`
`Summary table of economic
`analyses (models)
`
`Page 143
`
`Medtronic Exhibit 1014
`
`I29
`
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`
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`
`

`

`Appendix [0
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`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
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`

`

`Appendix [0
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`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
`
`Appendix I
`
`I
`
`Summary of economic analyses
`(individual studies)
`
`Page 147
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`

`

`Appendix 1' I
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`
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`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
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`

`Appendix 1' I
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`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
`
`Appendix I 2
`
`Source of cost data for economic analyses
`
`TABLE 65 Sources of cast dam for economic anaiyses
`
`Source of cost data
`
`Study
`
`Bottom-Lip costing exercise in Europe
`
`BENESTENT || [CEAf’
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`Guidant (CU) "‘8
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`UK prices
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`
`Page 151
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`Page 152
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`Heahh TechnologyAssessment 2000; Vol. 4: No. 23
`
`Appendix I3
`
`Outcome measures reported by individual
`economic analyses
`
`TABLE 66 Outcome measures reported by individua! economic analyses
`
`Outcome measure
`
`EFS rate
`
`CosdEFS
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`Costr'outcome avoided
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`CosdQALY
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`BENESTENT II27
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`Page 153
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`Page 154
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`Heoith TechnoiogyAssessment 2000; Vol. 4: No. 23
`
`Appendix I 4
`
`Quality assessment of included
`economic studies
`
`TABLE 67 Quality assessment: design and methods
`
`Article
`
`West Midlands DEC'
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`Wessex [IiECI33
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`Boston Scientific'm
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`NiS
`
`NFC
`
`Yes
`
`No
`
`Yes
`
`4
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`5
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`6
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`No
`
`Yes
`
`Yes
`
`T
`
`No
`
`No
`
`No
`
`No
`
`No
`
`Yes
`
`Yes
`
`8
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`9
`
`Yes
`
`Yes
`
`NIA
`
`NIA
`
`NFC
`
`NiA
`
`NIA
`
`Schwicker 8r BanzmHfi
`
`Jackson et aim
`
`SHPIC'S
`
`OPUSIWeaver et aL' '6
`
`BENESTENT ll”
`
`Peterson et til.I52
`
`Palmer et aim
`
`Cohen et ai. (l‘i‘i‘i‘)"‘5
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`No
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`NiC
`
`No
`
`No
`
`Yes
`
`Yes
`
`No
`
`No
`
`Yes
`
`Yes
`
`Yes
`
`Ni‘C
`
`Yes
`
`Yes
`
`No
`
`Yes
`
`NiC
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Ni‘C
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`No
`
`No
`
`No
`
`No
`
`Yes
`
`No
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`Yes
`
`NiC
`
`NiA
`
`NiC
`
`Yes
`
`Yes
`
`Yes
`
`NiA
`
`’ i. Research question stated
`2. Economic importance of research question stated
`3. Viewpointfs) ofanaiysis cieariy stated and defined
`4. Rationale for c