`
`Applicant(s)/Patent Under
`Reexamination
`
`Search Notes
`
`11 II 111 Ill 11 111
`
`13750352
`
`Examiner
`
`AARTI B BERDICHEVSKY
`
`SIGG ET AL.
`
`Art Unit
`
`3763
`
`Symbol
`A61 K9/0048OR A61 F9/008 OR A61M5178 OR A61M5/31
`
`I
`I
`
`Date
`5/8/2014
`
`I Examiner
`I
`ABB
`
`CPC-SEARCHED
`
`CPC COMBINATION SETS - SEARCHED
`
`Svmbol
`
`Date
`
`I
`I
`
`I Examiner
`I
`
`US CLASSIFICATION SEARCHED
`
`Class
`604
`
`I
`I 218,294
`
`Subclass
`
`I
`I
`
`Date
`5/8/2014
`
`I Examiner
`I ABB
`
`SEARCH NOTES
`
`Search Notes
`
`Date
`5/8/2014
`5/8/2014
`
`Examiner
`ABB
`ABB
`
`INTERFERENCE SEARCH
`
`US Subclass/ CPC Group
`
`Date
`
`Examiner
`
`EAST search
`Inventor search
`
`US Class/
`CPC Symbol
`
`U.S. Patent and Trademark Office
`
`Part of Paper No. : 20140507
`
`Novartis Exhibit 2051.001
`Regeneron v. Novartis, IPR2020-01317
`
`
`
`EAST Search History
`
`EAST Search History
`
`---
`
`..
`
`..
`
`..
`
`..
`
`...
`
`..
`
`....
`
`..
`
`..
`
`..
`
`..
`
`12014105/0B!
`.
`1 09.18
`i
`i
`i
`, PGPUB,
`1
`1
`I
`I
`I USPAT-
`I
`I
`I
`I
`'
`i
`i
`i
`I
`'
`I
`I
`I
`I
`!
`!
`!
`iUSOCR;
`I
`I
`I
`i
`!
`I DERWENT !
`I
`, ......... .l .............. , ................................................................................................ , ......................... · ......................... · .................... , .......................... ·
`
`I
`I
`I
`I
`I
`
`_ _
`
`USOCR;
`
`VEGF antagon;st ophlhWm$ sydnge
`silicone oil solution
`
`il""D ID 2014/05/08
`
`I
`
`11 :13
`
`______ __
`
`file:1//CI/U sers/abhatial/Documents/e-Red%20Folder/137 50352/EASTSearchHistory .13750352_Accessible Version.htm[ 5/8/2014 1 :34:51 PM]
`
`EAST Search History (Prior Art)
`................. ---i~e-;---------- IIDef;uit "ti~;~·i;!~.;;~ .... ----
`l~ef ![Hits
`![Search Query
`1 # .. .J _______ _I _
`.. _ .. _j St~mp ....
`_ __j
`..
`...
`..
`]l!)P_~r~tor _ _j
`r;N
`rND
`I ,;gg-j,ecgen$Jn.
`I U&
`12014/05/0B!
`I
`,
`i
`i
`1PGPUB;
`109:18
`i
`1
`I USPAT;
`I
`:
`I
`I
`I
`:
`:
`I
`!
`I
`I
`I
`iUSOCR;
`I
`I
`I
`I DERWENT I
`I
`I
`I
`I
`I
`r;N
`> ......... J ............. l ............................................................................................. , ..................... • ........................ • ................... , .......................... •
`rND
`I U&
`
`r 1□3
`r 10• i coyer-ch,;s$.;n.
`I[ 1 0 3 lbcyant-andcew$Jn.
`Ir 12014105/0B!
`I U&
`rND
`r 101 b,el1gen-h~ndch$Jn.
`I
`:
`I
`... . .. J Q~iT I __ .. __ .. _ ___] , .. _ .. __ I ... - ... I
`I J .. ,_.. I ..
`rN
`rND
`I U&
`r 101pkci-made$Jn.
`12014105/0Bi
`I
`,
`109:18
`I
`1PGPUB;
`I
`I USPAT;
`I
`:
`I
`I
`I
`I
`I
`I
`I
`l~~iT1
`. rD
`I
`' nn,,,,,J ,,,nn,,,,n· j nu,,,,,nn,,,n,n,,,nn,,,,n,n,,n,n,,,,nn,,,nu,,,,n,n,,,nu,,,,nn,,,,n,n,,, ! n,,,n,n,,,nn,,,,n, : ,nn,,,,n,n,,,nn,,, : ,n,,,n,n,,,nn· j n,n,,n,n,,,,n,n,,n,:
`I U&
`r 10, ("20060293270" I ·20100010309" I
`lCN
`I
`12014/05/0B!
`I
`I 09.18
`I PGPUB,
`I
`I
`I
`I
`I
`I
`I
`I USPAT;
`I
`!
`!
`I
`•USOCR
`!
`i
`i
`I
`'
`i
`I
`I
`I DERWENT !
`i
`I
`!
`!
`1 ......... J .............. J ............................................................................................. ...l ......................... i ........................ : ................. J .......................... i
`r i□I •13750352•
`l""D
`lCN
`I U&
`12014105/0Bi
`I
`i
`!
`l"20110257601"1"3012918"1"2078224"IIPGPUB;
`109:19
`!
`I
`I
`I
`I USPAT;
`I "6172944").PN.
`i
`!
`!
`!
`,ro
`I
`i
`!
`!USOCR
`!
`!
`'
`I
`1 ........ 1 .............. ! ............ _ .. , .. - .... - .................................... _ .. , .. - .... -
`..... _, ....................... 1 ....................... 1 ·-------· 2
`....................... 1
`r r442 IVEGFophlhaJm$
`,,CN
`I U&
`I
`12014105/0B!
`I
`I PGPUB·
`I
`I 09·52
`I
`'
`! USR'AT:
`!
`.
`!
`!
`i
`l
`' I '
`:
`I
`I
`I
`I
`IUSOCR;
`I
`I
`! DERWENT !
`!
`!
`!
`.. ,
`.,
`...
`..
`.... .l
`;Do !□!2014/05/08!
`I U&
`I
`IPGPLJB·
`I
`I
`!11•12
`I
`I
`I
`I
`I
`I
`I USPAT:
`I
`.
`!
`:
`:
`:
`,
`Dr642 I VEGF antagon;st ophlhaJm$
`I
`~
`~
`•USOCR
`i
`i
`I
`I
`I DERWENT :
`:
`I
`I
`'
`i
`I
`:
`. .............. , ................................................................................................................................................................................................. -
`I U& 'DD□ 2014/05/08
`I
`j USPAT;
`I
`I PGPUB;
`11 :13
`I
`I
`~J
`_ _ QERWENT j
`I
`I U&
`□D14
`, PGPUB;
`!
`I
`USPAT;
`I
`USOCR;
`DERWENT I
`
`...
`
`...
`
`...
`
`...
`
`..
`
`...
`
`..
`
`...
`
`109·18
`.
`~
`!
`
`I
`:
`I
`
`iPGPLJB·
`!
`'
`I USPAT;
`
`I
`:
`
`I
`:
`I
`
`I
`:
`
`...
`
`...
`
`..
`
`...
`
`..
`
`..
`
`...
`
`...
`
`..
`
`...
`
`.. _
`
`.... _
`
`.. _ , _ _ .. , _ ..
`
`'...
`
`..
`
`....
`
`..:
`
`:
`
`:
`
`:
`
`I
`~
`I
`
`I
`:
`I
`
`,
`'
`I
`
`I
`
`I
`
`:
`
`I
`I
`I
`I
`.. - .. ··-' ..
`
`t
`
`!
`
`~
`
`I
`I
`I
`I
`1 .. -
`
`I
`I
`t
`I
`.........
`!
`
`Novartis Exhibit 2051.002
`Regeneron v. Novartis, IPR2020-01317
`
`
`
`!
`
`'
`
`I
`
`I
`
`'
`
`I
`
`I
`
`I
`
`I
`
`'
`
`.... ....
`
`.... ....
`
`.... .... .....
`
`.... .....
`
`I
`.... I .... -
`
`I
`
`I
`I
`
`'DD ic! 2014/05/08!
`
`EAST Search History r 1 r21 I (A611<9/0048 OR A61 F9/000B OR
`, U&
`I
`I
`I
`i
`111:16
`IA61M5/1780RA61M5/31).CR::.
`I
`IPGPUB;
`i
`i
`i
`i
`i
`I USPAT·
`I
`I
`I
`I
`I
`I usocR'·
`rT53 IF6=04=/=2=18=,2=9=4=.cc=l=s.========"i, U&
`I
`I
`I
`I
`:
`'
`'
`.
`'
`!
`:
`:
`~
`I
`'
`I .... _.' _ .... _. J .. ....
`i, DE'""AIENT i,
`i,
`i,
`I
`i,
`i 2014/05/DBi
`nvv
`l""D
`lON
`I 12:06
`I
`I
`I
`I
`I
`I PGPUB;
`j
`I USPAT-
`I
`I
`I
`I
`I
`I
`lusocR:
`I
`!
`1□13 ;D41: VEGF·;~t·~ .. ~~i~t.~phth;1~$ sy~i-;;-g; .. g·I~· l ~~~ENT 1DD 1□: 2·0·1 .. 4/05/.08~
`r • r5 I VBlF antagoolst optrthalm$ sydoge glass I U&
`I
`I
`I 12:08
`I
`I
`I PGPUB;
`I silicone oil solution
`I
`I
`I
`I
`I
`I
`I
`I USPAT;
`i
`I
`I
`I
`i
`I
`i
`iUSOCR;
`I
`I
`i
`I
`I
`I DE~ENT I
`I
`I
`'DD 'ION
`1 ........ ' .............. ! ................................................................................................ , ........................ : ........................ : ................... , ......................... :
`r !Do I (1/BlF near2 antagoolst) ophthWm$
`I 2014/05/0BI
`I
`I 12:08
`I
`\
`I silicone oil solution volume
`I PGPUB;
`I
`I
`I
`I I
`I
`i
`i
`i
`'
`'
`' USPAT-
`'
`'
`!
`'
`'
`lusocR;
`lrD
`'
`I
`i
`I
`I
`I
`I DERWENT I
`1 ......... , .............. , ......................................................................................................................... · ......................... • .................... , .......................... ·
`r 6 !DI ( (glass w'th sydnge) ,,olume ·smoooe
`lON
`I U&
`I
`I
`I syringe glass silicone oil solution volume I PGPUB;
`I
`I
`I 12:09
`I
`12014/05/0B!
`'
`I
`' USPAT-
`I
`,
`I
`lusocR:
`!
`I
`I
`I
`!rD
`I ....
`'
`I
`' DERWENT I
`I
`'
`i .. _ .... __ i .... .....
`.... ....
`~ ..
`. I _ .... - ..... -
`'ION
`.... - ... i ....... ....
`....
`I 2014/05/ DBI
`I U&
`I
`I PGPUB;
`I 12:14
`I
`I
`I oil").clm.
`I
`I
`I USPAT;
`I
`I
`I
`I
`I
`I
`i
`i
`'USOCR-
`I
`I
`I
`I
`I
`I
`...
`.... .... .. .......................... .1 ~§3~~ .. 1. i ....... - ............. i .................. 1 ......
`I ....... l ......... _. l ....... .............................
`..... .... i
`'lst7 rB I (glass »rith sydnge) volume ·smoone o'I'' I U&
`l""D
`lON
`12014/05/DBI
`I
`I
`i
`!12:18
`I
`I
`I
`iPGPUB;
`'
`I
`i
`i
`i
`i
`i
`i USPAT-
`I
`I
`:
`lusocR·
`I
`I
`I
`I
`l .......... 1 ............... 1 .............................................................................................. 1 DERWENT.i ........................ i .................. 1 .......................... i
`IDD i□N
`12014/05/081
`iUS-
`r'D1"20130012918"
`i
`i
`I
`I
`I
`!12·28
`I
`IPGPUB·
`i
`'
`i
`.
`i
`I
`I
`I
`I
`I
`' USPAT-
`'
`I
`'
`I
`I USOCR·
`I
`I
`I
`I
`'
`I
`I
`I
`I
`i
`I ....... ...I ............. ...I ................................................................................................ l g§3~~:r..1 ........................ ! ................ ...1 .......................... 1
`I U&
`!ION
`_ rD
`12014/05/08:
`,12.28
`,PGPUB,
`1
`1
`1
`I
`I
`I USPAT;
`I
`I
`I
`I USOCR·
`i
`i
`i
`i
`i
`I
`i DERWEN' T I
`:
`l
`:
`:
`~
`••••n•n••••nn••n••n•••' •••n••n••••nn,,n,n' n~••••~n••n~••• • n••n••n••••nn,• ••n••••nn,,n,n•••nn'
`
`r 1□1"20120078224"
`ro 1D1"200601729-44"
`
`••••n•n••••nn••n••n••••nn••n•n•••n
`
`••••
`
`I US-
`,PGPUB,
`1
`I
`I USPAT;
`I
`IUSOCR;
`I DERWENT I
`
`1
`I
`i
`!
`
`112.29
`i
`I
`I
`
`1
`I
`I
`I
`
`I
`'
`I
`I
`
`,
`1
`I
`I
`i
`i
`I
`I
`:
`~
`~
`~ nn,,n· ~ °'''nn,,n,,· {" ••••
`
`I
`,
`1
`I
`I
`i
`I
`I
`I
`........ ..l ............. ..J
`
`_ r r 12014/05/08:
`n n "2006047325" ____________________________ , ~JD□ ~~:;;;05/08
`,0N
`i J 12:30
`lrD
`
`□□ "20070190058"
`
`..
`
`J~.
`
`.
`
`.
`
`.
`
`.
`
`.
`
`, US-
`PGPUB;
`I
`USPAT;
`I
`USOCR;
`DERW~Tj .
`
`.
`
`.
`
`.
`
`2014/05/08
`
`file:1//CI/U sers/abhatial/Documents/e-Red%20Folder/137 50352/EASTSearchHistory .13750352_Accessible Version.htm[ 5/8/2014 1 :34:51 PM]
`
`Novartis Exhibit 2051.003
`Regeneron v. Novartis, IPR2020-01317
`
`
`
`EAST Search History
`
`i "2007149334"
`i
`
`1,,,,,,. AND
`
`1,,,,,,. ON
`
`I
`
`i
`
`I PGPUB·
`
`I
`
`I
`
`!
`!
`
`----
`
`--
`
`--
`
`·--
`
`----
`
`----
`
`·----
`
`----
`
`r· !□! "2007084765"
`r IOI "20070238654"
`r7 l□I "2007035621"
`
`! 2014/05/081
`I U&
`I S23 I 2
`i
`I PGPUB;
`i 12:30
`I
`I
`I
`1.
`I
`1 USPAT;
`1
`I,
`I
`'
`:
`'
`'
`IUSCCR;
`'
`I
`I
`I
`I DERWENT I
`I
`I
`I
`I ........................... , ......................................................................................................................... , ....................... ~ .............................................. ,
`I
`I U&
`rND
`rN
`I 2014105/08,
`I
`I 12·31
`I
`I USPAT!
`I .
`I
`I
`I
`I
`i
`I
`I
`I
`I
`I
`i
`iUSCCR;
`i
`I
`I
`I DERWENT I
`I
`I
`I
`rND
`r5 i□i "20070128654"
`r;N
`I U&
`I
`i2014/05/08i
`I 12:32
`I
`I
`I
`I
`I PGPUB;
`I
`I
`I
`I
`I
`I
`I USPAT;
`I
`i
`I
`I
`I
`I
`!
`i
`iUSCCR;
`I
`I
`I
`I
`I
`I DERWENT I
`!
`lON
`lAND
`I
`i ......... , .............. , ......................................................................................................................... • ......................... • ............................................... •
`I U&
`1201410510a:
`'
`, PGPUB·
`i
`,
`' 12·32
`1
`1
`1
`'
`I
`i
`I
`'
`i
`.
`I
`I
`!
`,
`,
`'
`'
`' USPAT
`'
`·
`'
`I
`I
`I
`I
`I
`I
`I
`iusccR;
`I
`I
`I
`I DERWENT I
`I
`I
`I .... _ .. , ......... _ .... , ...... ............. .... ............. ............. ............. .. ........... ~ .. ............. ..., ....... - ............. ~ ............ _..... ...... .... .. ....... ,
`I
`l□D
`I
`I U&
`loN !2014/05/081
`I
`I
`!
`i
`i
`IPGPUB·
`i12·33
`•
`i
`I
`I
`,
`I
`·
`,
`'
`,
`I
`I
`I USPAT;
`I
`I
`I
`I
`I
`I
`'
`I
`I
`I
`I
`!USCCR;
`!
`I
`'
`i
`i DERWENT I
`i
`i
`I
`--
`--
`I ....... ' _ .... _. ' .....
`' ·--
`----
`----
`-- ' ----·---------- '------------··' ----
`'
`.. .. ----
`·----
`r•1□i"11992110"
`l□D
`I
`IU&
`!ON !2014/05/081
`I
`I
`!
`I
`IPGPUB·
`112·34
`I
`I
`'
`I
`'
`I
`I
`.
`I
`I
`I
`.
`'
`I
`I USPAT
`I
`I
`'
`I
`I
`I
`I
`lum· I
`I
`I
`I
`I .......... 1 ............... 1 .............................................................................................. I ~.~~~:r.1 ........................ 1 .................. 1 .......................... 1
`r9l□l"2006128564"
`l□D
`I
`IU&
`loN !2014/05/081
`I
`I
`!
`i
`IPGPUB·
`I
`i12·34
`I
`'
`i
`,
`i
`.
`I
`I
`I
`I
`'
`I
`' USPAT
`I
`I
`I
`I
`I
`'
`I
`I USCCR·
`I
`I
`I
`I
`i
`1 .......... 1 ................ 1 ............................................................................................. ...l ~!?.3~~:r..I ........................ I ................... 1 .......................... I
`I U&
`IIAND
`!ION
`I
`12014/05108!
`I
`I
`I
`I
`I
`IPGPUB;
`112:35
`'
`I
`I
`I
`I
`!
`I USPAT;
`i
`I
`I
`I
`I
`I
`I
`IUSCCR;
`i
`I
`I
`I
`I DERWENT I
`I
`I
`I
`
`,,,,,
`
`,,,,
`
`,,,,,,
`
`,,,,
`
`,,,,,n,,,,,,n,,,,,nn,,,, ' ,,,,
`
`,,,,,
`
`,,,,
`
`, ' ,,~,,,,~,,,,,,~,,, • ,,,,,nn,,,,,n,,• j>
`
`,,,,,
`
`,,,,
`
`,,,,,n,'
`
`ro 1D1"20080312607"
`r 1□1 "2006047325"
`
`~ n,,,,,,. } ,,,n,,,,,n,• j
`
`,
`
`,,,,
`
`,,,,,
`
`,,,,,
`
`,,,,
`
`l□D 10N
`I U&
`12014/05/081
`I
`i12·35
`IPGPUB·
`i
`I
`I
`I
`I
`I
`'
`.
`'
`'
`'
`I
`'
`'
`I
`'
`' USPAT
`i
`I
`I
`I
`!
`I
`I
`I USCCR·
`I
`I
`I
`I
`I
`i
`I ... J ·-----J "" ""
`·-- "" J QE[:!y\/~T j ------------ j _______ . ___ I ___ . "" "" I
`·-- "" "" "" "" "" ""
`l□ND
`r2 !□1"201578690"
`I
`loN !2014/05/081
`I
`I
`I
`I
`!
`i12·36
`I USPAT!
`I
`i
`I .
`I
`I
`I
`i
`I
`' ........ J ............. ...1 ............................................................................................. ...1 DERWENTJ ....................... J .................. 1 ......................... 1
`'I(US-20140012227-$orU&20110257601-IU&
`!AND
`I
`. PGPUB;
`$ or U&20060293270-$ or U&
`I
`20100310309-$ or U&20070253985-$ or USPAT;
`I
`U&20130338606-$ or U&20130012918-$ USCCR;
`DERWENT I
`or U&20120078224-$ or U&
`I
`20060172944-$ or U&20070190058-$ or I
`U&20070238654-$ or U&20080312607-$'
`I
`I
`or U&20130197451-$ or U&
`I
`20120171386-$ or U&20120123345-$ or
`I
`I U&20110276005-$ or U&20020038111-
`
`I
`
`I
`
`333 44
`
`IU&
`IPGPUB·
`
`I USCCR·
`
`I
`
`!
`
`i
`
`I
`
`ON
`
`2014/05/08
`13:06
`
`file:1//CI/U sers/abhatial/Documents/e-Red%20Folder/137 50352/EASTSearchHistory .13750352_Accessible Version.htm[ 5/8/2014 1 :34:51 PM]
`
`,
`
`Novartis Exhibit 2051.004
`Regeneron v. Novartis, IPR2020-01317
`
`
`
`EAST Search History
`
`I
`
`!
`
`r lo• i "60900•1•
`
`~
`
`~
`
`l
`
`I $) .did. or ( U&6172944-$ or U&3012918- I
`I
`I$ or U&2078224-$ or U&8668972-$ or
`I
`i U&8603638-$ or U& 7303748-$ or U&
`I
`I 8168584-$ or U&6689118-$ or U&
`I 6569143-$ or U&6494865-$ or U&
`I
`I 6189195-$).did. or (U&3012918-$ or U& I
`I 2078224-$) .did. or (GB-2500092-$ or
`I
`i W0-2006047325-$ or U&20070293432-$ I
`I or W0-03047244-$ or W0-2007084765-$ I
`i
`I or W0-2007035621-$ or WO-
`I 2006128564-$ or 0\1-201578690-$ or AU-I
`·
`I
`12013100360-$ or AU-2013100145-$ or
`I
`I AU-2013100146-$ or AU-2013100147-$
`I
`I or AU-2013100071-$ or AU-2013100070- I
`,
`I,
`'$) d'd
`'
`:DON i 2014/05/081
`I u&
`in41D4 :IS3~ '.;,d S8 ml
`I
`,
`,,AND
`I PGPUB·
`!
`!
`!
`!
`i 13-19
`I
`i
`i
`i
`.
`I
`I
`I
`! USPAT:
`!
`I
`I
`I
`I
`I
`lusocR:
`r..
`1
`I ....... J ............. j .............................................................................................. 1 12.§.~~:!:.1 ........................ 1 .................. j ......................... I
`I U&
`ND
`12014105/0BI
`i
`,
`,
`• PGPUB·
`! 13·30
`i
`i
`i
`!
`I
`~
`' USPAT-
`!
`!
`,
`I
`!
`!
`!
`i
`lusocR·
`I
`I
`I
`I
`I
`!
`I
`'
`I DERWENT I
`:
`I
`I
`' ........ .J .............. , ................................................................................................ , ......................... · ......................... · ................... , ......................... ·
`EAST Search History (Interference)
`
`I,',,,.
`
`I,
`I,.
`
`I,,,.
`
`I,.
`
`I,,,,
`
`!,,
`I
`
`!
`i
`;
`
`1,,,
`
`I,',,,.
`
`I,
`I,.
`i
`!,',,.
`I,,,,
`
`!,,
`
`!
`
`I
`I,
`1,.
`i
`!,',,,,,,.
`
`I,
`!,,
`I
`
`:
`
`•
`
`:
`
`1 1A
`
`:
`
`I
`
`< This search history is empty>
`
`5/8/2014 1 :34 :46 PM
`C:\ Users\ abhatia1\ Documents\ EAST\ Workspaces\ 13750352.wsp
`
`file:1//CI/U sers/abhatial/Documents/e-Red%20Folder/137 50352/EASTSearchHistory .13750352_Accessible Version.htm[ 5/8/2014 1 :34:51 PM]
`
`Novartis Exhibit 2051.005
`Regeneron v. Novartis, IPR2020-01317
`
`