`PAPERBACK REFERENCE
`
`ffi
`ffiffi
`
`THIRD EDITION
`
` PFIZER, INC. v. NOVO NORDISK A/S - IPR2020-01252, Ex. 1028, p. 1 of 4
`
`
`
`Orford Uuioetsitl Ptess, Walton Street, Otlord oxz 6ov
`OxJord New Yorh
`Athens Auchland Banghoh Bombay
`Calcuttq Cape Tozon Dat es Salaant Delhi
`Florence Hong Kong Istanbul Karachi
`Kt,ala Lurnpur Madras Madrid Melbowne
`Mexico City Nairobi Paris Singapore
`Taipei Tohyo Torcnto
`and associated cornpanies in
`Berlin lbadan
`
`O$otd is a trade math of OtJoul flnitersitl press
`
`@ Marhet House Boohs Ltd. 19t5, 1990,1996
`
`First published 19Ej as A Concise Dictionary of Chemistry
`Second edition 1990
`Thitd edition I 996
`
`All righ* reserved, No part of this publication nay be reptodtrced,
`storcd in a retrieilal y)sten, or trailsmitted, in any-Jorm ir by iiy'-"orr,
`without the ptiot permission in writing of Oxlori ilri""uitj
`iiirr.'--
`Wirhin the UK, exceptiont are allowid in reipect o1 ooy Joi, a"iiinp fo, tt "
`pkrpose.of /esearch or I,rivate study, or uiticism ui rcaiew, as Oenitied
`undet the Copytight, Designs and patents Act, I9gg, or itt thi ur" oi
`rcptogtaphic reprcduction in arcordance with the rerms oJ the liceicis
`'
`issued by the Copyright l.ircnsing Agency. Enquiries conierlii"
`teproduction outside these toDB and in other ciuntries should i)
`sent,to the-Rights Department, Otlord unioersiry press,
`at the address abote
`
`This booh is sold subject to the con(lition that ir shal! not, by way
`of.trcde or othetwise, be lent, re-sold, hired oil or otherzli{e ciliulated
`without the publisher's priot consent in any forn oJ binding o, ,orii-
`other thqn that inuhih it is published and withoit o siniiar riiaitio,
`including this condition beiug imposed on the subsequent putchaset
`British Libraty Cataloguing in ptblication Data
`Data aztailable
`
`Library oJ Cotgress Cataloging iil publication Data
`ISBN 0-19 280031_.0
`1098765432
`
`Printed in Great Britdin by
`Machays plc
`Chatham, Kett
`
` PFIZER, INC. v. NOVO NORDISK A/S - IPR2020-01252, Ex. 1028, p. 2 of 4
`
`
`
`buckyball
`
`80
`
`',t.:.
`
`. .lf
`
`Buckminsterfullerne
`to produce forms of carbon in which the atoms are linked in a cylindrical,
`rather than spherical, framework with a diameter of a few nanometres.
`They are known asbuckytubes (or nanotubes).
`buckyball See buckminsterfullerene.
`buckytube See buckminsterfullerene.
`buffer A solution that resists change in pH when an acid or alkali is
`added or when the solution is diluted. Acidic buffers consist of a weak acid
`with a salt of the acid. The salt provides the negative ion A-, which is the
`conjugate base of the acid HA. An example is carbonic acid and sodium
`hydrogencarbonate. Basic buffers have a weak base and a salt of the base
`(to provide the conjugate acid). An example is ammonia solution with
`ammonium chloride.
`In an acidic buffer, for example, molecules HA and ions A- are present.
`When acid is added most of the extra protons are removed by the base:
`A-+H*-+HA
`When base is added, most of the extra hydroxide ions are removed by
`reaction with undissociated acid:
`OH-+HA+A-+HzO
`Thus, the addition of acid or base changes the pH very little. The hydrogen-
`ion concentration in a buffer is given by the expression
`r(" = tH.l= [A-l/[HAl
`i.e. it depends on the ratio of conjugate base to acid. As this is not altered
`by dilution, the hydrogen-ion concentration for a buffer does not change
`much during dilution.
`In the laboratory, buffers are used to prepare solutions of known stable
`pH. Natural buffers occur in living organisms, where the biochemical
`reactions are very sensitive to change in pH. The main natural buffers are
`H2CO3/HCO3- and H2PO,-/HPO42-. Buffer solutions are also used in medicine
`
` PFIZER, INC. v. NOVO NORDISK A/S - IPR2020-01252, Ex. 1028, p. 3 of 4
`
`
`
`81
`
`butanoic acid
`
`(e.g. in intravenous injections), in agriculture, and in many industrial
`processes (e.g. dyeing, fermentation processes, and the food industry).
`bumping Violent boiling of a liquid caused by superheating so that
`bubbles form at a pressure above atmospheric pressure. It can be
`prevented by putting pieces of porous pot in the liquid to enable bubbles
`of vapour to form at the normal boiling point.
`Bunsen burner A laboratory gas burner having a vertical metal tube into
`which the gas is led, with a hole in the side of the base of the tube to
`admit air. The amount of air can be regulated by a sleeve on the tube.
`When no air is admitted the flame is luminous and smoky. With air, it has
`a faintly visible hot outer part (the oxidizing part) and an inner blue cone
`where combustion is incomplete (the cooler reducing part of the flame).
`The device is named after the German chemist Robert Bunsen (1811-99),
`who used a similar device (without a regulating sleeve) in 1855.
`Bunsen cell A *primary cell consisting of a zinc cathode immersed in
`dilute sulphuric acid and a carbon anode immersed in concentrated nitric
`acid. The electrolytes are separated by a porous pot. The cell gives an e.m.f.
`of about 1.9 volts.
`burette A graduated glass tube with a tap at one end leading to a fine
`outlet tube, used for delivering known volumes of a liquid (e.g. in
`titlation).
`buta-1,3-diene (butadiene) A colourless gaseous hydrocarbon,
`CH2:CHCH:CH2; m.p. -109"C; b.p. -4.5"C. It is made by catalytic
`dehydrogenation of butane (from petroleum or natural gas) and
`polymerized in the production of synthetic rubbers. The compound is a
`conjugated *diene in which the electrons in the pi orbitals are partially
`delocalized over the whole molecule. It can have trans and cis forms, the
`latter taking part in *Diels-Alder reactions.
`butanal (butyraldehyde) A colourless flammable liquid aldehyde, C3HTCHO;
`r.d. 0.8; m.p. -99oC; b.p. 75.7'C.
`butane A gaseous hydrocarbon, CoH16; d. 0.58 g cm-3; m.p. -138"C; b.p. 0'C.
`Butane is obtained from petrbleum (from refinery gas or by cracking
`highel hydrocarbons). f'he fourth member of the *alkane series, it has a
`straight chain of carbon atoms and is isomeric with z-methylpropane
`(CH3CH(CH3)CH3, formerly called isobutane). It can easily be liquefied under
`pressure and is supplied in cylinders for use as a fuel gas. It is also a raw
`material for making buta-1,3-diene (for synthetic rubber).
`butanedioic acld (succinic acid) A colourless crystalline fatty acid,
`(CH2)2(COOH)2; r.d. 1.6; m.p. 185"C; b.p. 235'C. A weak carboxylic acid, it is
`produced by fermentation of sugar or ammonium tartrate and used as a
`sequestrant and in making dyes. It occurs in living organisms as an
`intermediate in metabolism, especially in the *Krebs cycle.
`butanoic acid (butyric aeid) A colourless liquid water-soluble acid,
`
` PFIZER, INC. v. NOVO NORDISK A/S - IPR2020-01252, Ex. 1028, p. 4 of 4
`
`