`IPR Petition - USP 10,435,742
`
`
`
`“:gn‘h
`$237",
`
`'"ny‘
`‘1
`
`',',n.
`
`.
`
`_“
`1
`
`'
`
`,1 2-,,
`_'
`
`.
`
`1
`, — H: }")~:_r;fir:/%J11;5;,” fly;
`.
`.3
`33-“{76Wm,«amfld‘é r
`’
`K
`
`
`
`©1974,1975,1976, 1977, 1978, 1979, 1980, 1981,1982, 1983,1984,1985, 1986,1987, 1988, 1989, 1990,1991 by CRC Press, Inc.
`
`©1964, 1965, 1966, 1967, 1968, 1969, 1970, 1971, 1972, 1973 by THE CHEMICAL RUBBER CO.
`Copyright 1918, 1920 by The Chemical Rubber Company (Copyright renewed 1946, 1948 by The Chemical Rubber Publishing Company)
`
`Copyright 1922 (Copyright renewed 1950), 1925 (Copyright renewed 1953), 1926 (Copyright renewed 1954), 1927 (Copyright renewed 1955), 1929
`(Copyright renewed 1957),1936,1937 (Copyright renewed 1965 by The Chemical Rubber Co. ), 1939, 1940 (Copyright renewed 1968 by the Chemical
`Rubber Co.), 1941 (Copyright renewed 1969 by The Chemical Rubber Co.), 1942 (Copynghtrenewed 1970 by The Chemical Rubber Co), 1943
`(Copyright renewed 1971 by The Chemical Rubber Co), 1944 (Copyright renewed 1972 by The Chemical Rubber Co.), 1945 (Copyright renewed
`1973 by The Chemical Rubber Co.), 1947, 1949, 1950, 1951, 1952 (Copyrrght renewed 1980 by CRC Press, Inc.), 1953 (Copyright renewed 1981a
`'by CRC Press, Inc.), 1954 (Copyright renewed 1982 by CRC Press, Inc.), 1955 (Copyright renewed 1983 by CRC Press Inc.), 1956 by Chemical
`Rubber Publishing Company
`.
`.,
`.
`.
`
`4 ©1957, 1958, 1959, 1960, 1962 by Chemical Rubber Publishing Company
`
`All Rights Reserved
`Library of Congress Card No. 13—1 1056
`PRINTED IN U.S.A.
`
`
`
`.
`
`.-
`
`.
`
`, ¢ .
`
`l .L .4 .. we. —»
`
`,. ». .'-1':.*l ,.L1_’\;.-'l>' , 5'".
`
`41: new «mi ‘.’ I ~41!th Hyatt Na?" 14’» ”11+“, 3.21.
`
`ri.’
`
`QED-41'1“?
`
`11:! “17' {91111-713133
`
`
`
`
`
`Ste”
`
`RULE No.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`i
`
`
`
`
`
`
`
`
`
`e
`i
`
`
`
`
`
`
`
`:1
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`lllll H A-Zl
`Rm
`telpene..........
`. ..... A-71
`A 7: NO.
`..............
`unbmnched
`ULEN
`'
`or hete
`4A_31
`R l
`ame
`....... A-21
`I
`DersyStemf
`n
`12
`RadlCOfunCtionaln
`5A36A41
`....... A-ll
`0.
`moychccom
`subsgiundS‘I
`'
`'
`Gr 4
`Repagementname
`.
`i
`‘
`.
`i
`.
`.
`.
`A_
`3.
`H ’
`' H
`.....
`..... I
`A?)
`u
`unsattlrated
`' A- .
`.
`i
`.
`‘
`I
`I
`.
`I
`I
`‘
`~
`1
`.
`.........H
`OS
`.1n
`.
`.
`.
`. A-51
`lHr
`umvename
`lllllllll B4
`Subt
`G1 SEW.
`g ystemsE
`»
`.
`------.
`A—41,A—42
`S motivename
`I‘‘‘‘‘‘I
`— 1(a).r
`i
`I
`I
`ossary
`assemblies.“7
`.
`.
`.
`A
`yStematicn
`I
`i
`I
`i...... Glossar
`bridged
`............
`A-
`.
`.
`~71
`ame
`......
`y
`"""" 5
`.
`.
`A2].6
`Terpen
`...... Glossary
`t‘fused” .
`-------
`A31toA—54
`)OIIS..
`.
`A
`Tet k lllliIIIII
`Glossar
`Splro..
`_
`V
`.......... A ltoA35
`H
`I
`'
`.
`I
`-
`'
`I
`es.
`‘
`i
`V
`.......I
`‘
`llllI....... "
`1p0und'
`-23 .
`V
`T mls,useOf.
`I
`.
`h
`.‘‘‘‘‘A-“t
`y
`.
`,r;-----3.....A-41 A.I
`‘21toA38I
`S
`B—l
`ricydocompou d...........
`OA75
`Sldechains
`U
`; 42,B-lO Bill
`.
`.
`.
`.
`A—22
`griS)useOf
`nSIIIIIIIIIIIIII
`11:25
`aliphaticsei'iesuH
`I
`i
`A22
`rivalentradi
`.llllllll
`32
`eyelicSyste
`lllllll
`'
`.
`A24
`TrivialnamesGals. llllllllllllllA A25
`Spiro
`ms
`lllllllllllllll
`A—2
`,
`.......
`A—2.6
`hydrocarbons
`' A-61'0'fheterocyciié.'
`i..........
`4B513
`.
`.
`heterocyclics............. A-
`Ofpelydyclichggmpoundslllllll Glossary:
`.
`B4
`.
`.
`YStems......Biii?)A42
`Unsaturtd
`yrocarbons
`...... B2
`.
`—
`_
`.....
`B 1
`I......l;
`.A;
`l
`I
`ae h
`'
`I
`‘HI
`IGlossary
`.
`N
`11”
`vonBae
`Yd100arbons...A-3 A1
`21‘
`....... A_31
`aInes0fRadicals
`yerSyStem '
`y
`_ 1’Ahgl‘g
`V
`Che'
`IH A34
`CHICON
`andSide-Chains
`'
`lllllllllll A313
`I
`I
`IH
`.
`314.1(1))
`CCtyI
`CH,C(==11];
`,.
`.Glossary BIOSSaly
`EHJCOCI-LCO— '
`“n"amyl(3-pi1:nklmcarbonyn
`ONCE)”—
`’G'l
`.
`CHJCOCH,
`c”‘namovl
`yzupmpenyn
`CHICO—I
`L
`A
`......
`ossary
`CHCOC
`—
`Ch]
`IIIIIII G
`‘
`J
`I, HCONH~
`oroformyl
`h
`' Giossary'
`.
`-
`'
`(3220:8014:
`c"“‘firnylidene
`O‘HSCHECHCHr
`J.
`I Bossary‘
`I
`'
`CH:=CQC
`:Iesyuhydroxymethyiphenl
`E‘ESCH=CHCO_
`.
`_
`1
`‘
`41(a)
`’—0C(CI_I0—
`Gmm
`H40SCH=CHCH=
`H
`IIIII Glossary
`CHCH,j‘coé
`rotyl(2bulényi)
`c (CHJ)CiH._
`........
`.
`~HN’
`(NHleQ;
`cyanamidokyénoam
`HJCH=CHCO_
`........
`H (CHmCO—
`cyanato
`.
`in?)
`CHJCH=CHCH
`.....
`.cfiNfngCO— ~
`”a”
`’7
`”cm" i
`K
`'lt
`:- HCH
`H
`NC0_
`’
`1.1‘
`CH1=CHCHL
`d
`‘
`NC“
`.22,A—ZA A25
`HINCFNH_
`decanedioyl
`H ‘
`...... A-31 ,
`ainfhenylamino)
`C]; C
`dim
`”Gammo—
`7‘
`’
`'
`V
`.
`.
`HN_
`)
`ecanoly
`,
`,
`inls"""' A-11
`.
`4
`c.§(N‘fiz)1_,
`dimamino
`CHKCHJHCOW
`v
`,
`...... A-22
`CH21c—
`man“
`N2:
`" '
`‘
`........ A324
`CHBCJLNH— '
`dmhmnfiyi9'r
`—NHN=N_
`IIIIIII
`13-15
`..
`2—};NéH‘CO—'
`disuifinyl
`H:SiSiH,—
`‘
`V
`.
`-.A-22 A24
`ASH:_ «Hico— -
`dithio
`H§(S(i)OSiH,o—.
`
`V
`’
`-
`:
`“I3':
`_
`l
`_'
`)S(O—
`m.1.2325,A531
`No_C(CH,),cO_
`enanthyl
`—sS_
`)
`.....
`-22,11-2.4
`—N=N-
`etienywnyl)
`CgJCHahco—l
`_ _
`m'
`.
`'
`'A'51toA—54
`4m:
`epoxy
`'7
`_N(Q)N_
`aha):
`CH:=CH—
`..........
`“
`I.
`HCEC—
`CH
`—
`I.
`.
`ethyl
`do“)
`lps.I
`’
`.
`.
`I
`..
`..
`C,“,EH— 7
`ethylthio
`CszO—r
`.
`,
`“
`nzoxy(b e"zylimli‘l0)
`.........
`i
`(a:AONH— '7‘
`CHJCHF
`-21-3,A—23 B-
`nzoyloxy)
`C56Hs)zCH
`formamido(form
`Gil-Ls—
`‘
`......
`(i
`,CsH,coo—
`f“
`y
`HCON
`,
`yiamino)
`”:5“NH)-
`form1
`.
`{ EH5“).—
`fmaroyufromfumaricacld
`HCO H—
`.7
`A.
`I
`t
`I
`*OC_
`I CGHCH1
`{urfurylI(2~furanylmethyi)")
`23.1,B“ I
`V“
`O
`CH=CHCO—
`GEO“:
`urfuryiidene(2-furanl
`'
`OC‘H’CHI—
`ChHJC:
`fury]“many”
`‘ymethylene)
`.
`.
`.
`.
`0C1HJCH=
`mmH .
`,5
`..
`
`
`.
`a:l
`iH
`5
`Y
`I”
`2r
`'
`..A-ZIA
`ih
`I—C‘HCi;_
`glutamyl(fromglutami
`C‘HJ—
`'
`
`
`-
`23.1 B—11’
`4’
`CiHof...
`gluzarylmomglutar' Cindy
`I
`
`
`
`
`, —1.2
`’
`i
`C
`glycmyuox.
`_
`'0C(CH:)CH
`1cacid):
`V
`A—25
`.........
`(EECWCH)O'_-'
`siyeinamidrimnymethyl)
`HOC(CH’)ZCO(NH1)CO_VJ
`
`
`
`
`
`
`A21.4,13—42
`10meth
`CHsEéH
`gly°°1yl(hydroxya¢el1
`CH]CHCHIT:
`-
`
`
`
`
`l1
`Ylpropyl)
`(CH
`‘)1
`glycyHaminoaceti Y)
`f”
`“INCHICONHH
`
`
`
`
`dimethmth I
`&
`MC11,),
`gIYnyI1
`Y)
`Y
`HOCHco-
`
`
`A
`W
`I
`I
`'
`h
`.
`~
`I
`CZHSCHCHD—
`8uanid'y(oxoacetyl)
`HzNCI-iCO
`:
`
`
`'
`,_
`_
`.
`.
`.
`(CH 0—
`1
`‘“°
`b:
`...... Al.
`”(from
`‘
`CJH’EOH
`HCOCo-
`Suanyi
`
`
`
`
`......... A-
`tomc:aprolcacid)
`7
`EINCFNHWH—
`
`
`Dticacid
`in
`......
`heta
`NC=
`—
`
`
`(fromcamuczudf‘.
`HH ilk-.255A“
`qH9ch;)4co_—
`Mimi???“
`s:
`_
`(,N,_H>
`
`
`’A
`I
`I
`CH:(CH1)HCO_‘
`h
`’1o
`12';CH
`_
`~
`.
`(-2
`
`
`I
`I
`CH >
`cptanedioyi
`J<CH2>HCOV
`114
`:(cmco—
`Wan“
`CHJCH)C
`,aminocab
`,A-ll.5
`.
`H1NCONH_
`h
`y
`_OC
`1”ON}!—
`
`
`
`
`1(hydraz.ronyll)
`..... A4’.
`Hcho_
`exadeca‘myl
`C
`(anaco—
`
`
`
`Inocmbonyi)
`-,
`~
`.
`.
`.
`HzNCQ‘
`hexamethy‘ene
`HACHILCOH
`......... A
`I
`HzNNHC
`“Fm“edbyl
`CHJCH‘LCOHL
`
`I
`Cszo(3.0—
`h1PDUryl(N.ben10ylgl
`:(CHm—
`
`
`CsHC;! >
`OC(CH1)4CO_
`hydantoyl
`hydrazine
`CGHSCONHCHICO—
`_C._.‘O__101C“ 5
`:
`i
`hymn
`SINCONHCPLCO—i
`
`
`hydrocinnamo l
`INNH—
`~HNNH— ‘
`i
`(
`y
`
`
`HOOC—
`C5H5(CH2);CO—
`‘
`
`
`V
`
`.1
`
`
`
`i
`
`i
`:
`
`
`
`i
`
`V
`
`-
`
`-
`
`
`
`’-
`
`
`
`
`
`
`L
`.
`
`‘
`
`i
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`—
`
`
`
`
`7.
`
`;.
`
`*
`
`'
`
`
`
`,
`_,
`
`1
`
`
`
`ycyl)
`
`