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`UNITED STATES PATENT AND TRADEMARK OFFICE
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`------------------------------------X
`ILLUMINA, INC.,
` Petitioner,
` vs.
`THE TRUSTEES OF COLUMBIA UNIVERSITY
`IN THE CITY OF NEW YORK,
` Patent Owner.
`------------------------------------x
` IPR2018-00291 IPR2018-00318
` IPR2018-00322 IPR2018-00385
` IPR2018-00797
`
` VIDEOTAPE DEPOSITION
` STEVEN M. MENCHEN, PH.D.
` New York, New York
` January 14, 2019
` 9:21 a.m.
`
`Reported by:
`ERICA L. RUGGIERI, RPR
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`800-642-1099
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`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`Illumina Ex. 1048
`IPR Petition - USP 10,435,742
`
`

`

`Page 2
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` January 14, 2019
` 9:21 a.m.
`
` Videotape Deposition of
`STEVEN M. MENCHEN, PH.D., held at
`the offices of Venable Fitzpatrick,
`1290 Avenue of the Americas, New
`York, New York, pursuant to Notice,
`before Erica L. Ruggieri, Registered
`Professional Reporter and Notary
`Public of the State of New York.
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`David Feldman Worldwide
`A Veritext Company
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`www.veritext.com
`
`

`

`Page 3
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`A P P E A R A N C E S:
`ATTORNEYS FOR PETITIONER:
` KNOBBE MARTENS
` 12790 El Camino Real
` San Diego, California 92130-2008
` By: NATHANIEL R. LUMAN Ph.D., ESQ.
` nate.luman@knobbe.com
`-and-
` WEIL, GOTSHAL & MANGES, LLP
` 201 Redwood Shores Parkway
` Redwood Shores, California 94065-1175
` BY: EDWARD R. REINES, ESQ.
` edward.reines@weil.com
`ATTORNEYS FOR PATENT OWNER:
` VENABLE FITZPATRICK
` 1290 Avenue of the Americas
` New York, NEW YORK 10104
` By: ROBERT S. SCHWARTZ,Ph.D., ESQ.
` rschwartz@Venable.com
` JOHN D. MURNANE, ESQ.
` jmurnane@venable.com
` ZACHARY L. GARRETT, ESQ.
` zgarrett@venable.com
`
`ALSO PRESENT:
` JOHN WHITE, Cooper & Dunham
` JEFFREY L. KESTLER, Columbia
` MARCUS BIRCH, Illumina
` KARYN Y. HUI, Columbia University
` TERESA CHEN, Columbia University
` FLOYD ROMESBERG, Scripts Research
` Institute
` DEVERELL WHITE, Videographer
`
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`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

`Page 4
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` THE VIDEOGRAPHER: We are
` going on the record at 9:21 a.m. on
` January 14, 2019. Please note that
` the microphones are sensitive and
` may pick up whispering and private
` conversations.
` Please place all cellphones
` away from the microphones as they
` can interfere with deposition
` audio.
` Audio and video recording will
` continue to take place unless all
` parties agree to go off the record.
` This is media unit one of the
` video recorded deposition of
` Dr. Steven Menchen taken by counsel
` for the petitioner in the matter of
` Illumina, Incorporated versus The
` Trustees of Columbia University in
` the City of New York, IPR
` 2018-00291, 318, 322, 385, 797.
` This is filed in the U.S. Patent
` and Trademark Office.
` We are at the offices of
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`A Veritext Company
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`www.veritext.com
`
`

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`Page 5
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` Venable Fitzpatrick located at 1290
` Avenue of the Americas, New York,
` New York.
` My name is Deverell White
` representing Veritext Legal
` Solutions.
` At this time will counsel
` please state their appearances.
` MR. REINES: Edward Reines on
` behalf of the petitioner.
` MR. LUMAN: Nate Luman on
` behalf of petitioner.
` MR. BIRCH: Marcus Birch,
` Illumina.
` MR. ROMESBERG: Floyd
`Romesberg, Scripts Research
`Institute.
` MR. SCHWARTZ: And Robert
` Schwartz from Venable Fitzpatrick
` for Columbia University and the
` witness. And with me is John
` Murnane and Zachary Garrett from
` Venable Fitzpatrick. Also John
` White from Cooper & Dunham and Jeff
`
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`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

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` DR. STEVEN MENCHEN, Ph.D.
` Kestler, Karyn Hui and Teresa Chen
` from Columbia University.
`S T E V E N M. M E N C H E N,
`called as a witness, having been
`duly sworn by a Notary Public, was
`examined and testified as follows:
`EXAMINATION BY
`MR. REINES:
` Q. Please state your name and
`address for the record.
` A. Steve Menchen.
` Q. What's your address,
`please?
` A. 768 Vanda Way, Freemont,
`California.
` MR. REINES: We have -- I have
` entered into an agreement with
` opposing counsel that, at least for
` present purposes, we will keep your
` current employer confidential, but
` I just wanted to put on the record
` that we have an agreement that
` counsel for petitioners will be
` informed of that under -- under the
`
`800-642-1099
`
`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

`Page 103
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` DR. STEVEN MENCHEN, Ph.D.
` MR. SCHWARTZ: Objection to
` scope.
` A. So MOM stands for methoxy
`methyl. So that would be a
`single -- that would be like naming
`the compound.
` Q. And then you see the
`reference to allyl groups right next
`to it?
` A. I see it.
` Q. And is allyl groups
`referring to a single chemical
`structure or genus, according to
`you?
` MR. SCHWARTZ: Asked and
` answered.
` A. Refers to a genus.
` Q. And here Ju refers to the
`Kamal paper, correct?
` MR. SCHWARTZ: Objection,
` form.
` Q. This should be an easy one.
` A. It is known -- yes, he does
`refer to the Kamal paper.
`
`800-642-1099
`
`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

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` DR. STEVEN MENCHEN, Ph.D.
` Q. The Ireland publication
`supports the disclosure of MOM as a
`capping group and the Kamal paper
`supports the disclosure of allyl as
`a capping group; is that correct?
` A. So it is known that MOM and
`allyl groups can be used to cap an
`OH group. So -- and high yield. So
`could you repeat the question. I
`just want to make sure that I get
`this right.
` Q. The Ireland publication
`supports the disclosure of MOM as a
`high-yield capping group?
` A. That's right.
` Q. And Kamal supports the
`disclosure of allyl as a high-yield
`capping group?
` MR. SCHWARTZ: Objection,
` form.
` A. It supports propenyl, yes,
`Kamal does.
` Q. When you say propenyl, I'm
`referring to the sentence, I'm not
`
`800-642-1099
`
`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

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` DR. STEVEN MENCHEN, Ph.D.
`referring to other made up lexicons.
` A. I -- I'd have to look at
`Kamal.
` Q. I'm not asking what Kamal
`actually does, but in terms of how
`this disclosure discloses things,
`Ireland supports the disclosure of
`MOM as a high-yield capping group
`and Kamal teaches the disclosure of
`allyl as the capping group; is that
`correct?
` A. So that's --
` MR. SCHWARTZ: Objection,
` form.
` Let me get my objections in
` before you answer, please.
` THE WITNESS: I'm sorry.
` Q. That's correct, right?
` A. That's how they segregate,
`yeah.
` Q. Now, in terms of the
`teaching in column 3 of Ju, this is
`describing the state of the art
`before the invention, correct?
`
`800-642-1099
`
`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

`Page 106
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` DR. STEVEN MENCHEN, Ph.D.
` MR. SCHWARTZ: Objection,
` form.
` A. So Ju uses the present
`tense, it is known. So that's --
`you are going to have to give me a
`context for that.
` Q. Do you see in column 4
`there's a reference to the summary
`of the invention?
` A. Yeah. I do see that.
` Q. Okay. And you see in
`column 1 it refers to the background
`of the invention?
` A. Yeah, I see that.
` Q. And from your hundred
`patents you are familiar with that
`structure of patent application, of
`a description of the background of
`the invention?
` A. That's right.
` Q. And then the summary of the
`invention?
` A. That's right.
` Q. And the material in column
`
`800-642-1099
`
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`
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` DR. STEVEN MENCHEN, Ph.D.
`3 between line 20 and -- or 18 and
`54, is that describing the state of
`the art, correct, and not the
`invention of Ju?
` MR. SCHWARTZ: Objection,
` form.
` A. So you are talking 41 to 44
`is describing the state of the art.
`So it's describing the state of the
`art for an NOH group that a
`synthetic chemist would do, not
`necessarily a nucleotide. So it's
`basically -- so it describes NOH
`group that is disclosed in Kamal.
` Q. Let me just ask the
`question again. The paragraph
`starting in column 3 at line 17
`through line 54, do you have that --
`do you see that paragraph?
` A. Yeah, I see it.
` Q. Okay. This paragraph is
`describing a state of the art before
`Ju's work not Ju's invention,
`correct?
`
`800-642-1099
`
`David Feldman Worldwide
`A Veritext Company
`
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`

`

`Page 108
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` DR. STEVEN MENCHEN, Ph.D.
` MR. SCHWARTZ: Asked and
` answered.
` A. I would say it describes
`more than just the state of the art.
` Q. In this background of the
`invention section in this paragraph?
` A. Let me -- I -- I have to
`read the whole paragraph. Is that
`okay?
` Q. Yeah. No, please do. I
`didn't mean to interrupt you.
` A. So this is -- I would say
`this is Ju's view of the state of
`the art.
` Q. Okay. He's not attempting
`in column 3, lines 18 through 54, to
`describe his invention there, right,
`that comes later?
` A. I think he is attempting to
`describe his invention.
` Q. In this background of the
`invention section?
` A. Yeah.
` Q. Okay. And where do you see
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` DR. STEVEN MENCHEN, Ph.D.
`that?
` A. The approach disclosed in
`the present application is to
`incorporate nucleotide analogs,
`which are labeled with cleavable,
`unique labels such at fluorescent
`dyes or mass tags and where the
`3'-OH is capped with a chemically
`cleavable moiety such as either MOM,
`CH2OCH3 and allyl specifically, CH2CH
`CH2 into the growing chain strand of
`DNA as terminators.
` Q. You acknowledge the prior
`sentence starting "It is known
`that," that is describing the state
`of the prior art and not his
`invention?
` A. Let me go back.
` That's the state of the art.
` Q. And when he states what he
`thinks the invention is and --
`excuse me. When he states it says
`the approach disclosed in the
`present application, do you see that
`
`800-642-1099
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`

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` DR. STEVEN MENCHEN, Ph.D.
`sentence?
` A. I see that.
` Q. When he refers to using a
`chemical moiety such as an allyl
`group, do you see that?
` A. Yeah, I see that.
` Q. Okay. Is that referring to
`allyl the genus or a specific -- or
`just the specific chemical formula
`that's disclosed there?
` A. Yeah. He's -- he's
`defining it as propenyl.
` Q. In terms of Ju's disclosure
`of the invention, other than the MOM
`group or the propenyl, is there
`anything else that he discloses as
`usable for the 3' modification to a
`person of ordinary skill in the art?
` A. Yeah, I don't see anything
`else.
` MR. SCHWARTZ: Objection,
` scope.
` Q. Would a person of ordinary
`skill in the art reading the Ju
`
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` DR. STEVEN MENCHEN, Ph.D.
`patent and seeing the disclosure of
`the MOM group and the allyl
`disclosure understand that there's
`any commonality between those two
`chemical structures?
` MR. SCHWARTZ: Objection,
` form.
` A. The commonality that Ju
`describes is that they -- that they
`can be used to cap the OH group.
` Q. Anything else?
` A. And that they can be
`cleaved chemically in high yield as
`disclosed in the Kamal reference.
` Q. Anything else?
` A. That's what he says.
` Q. Can you identify anything
`else?
` A. No.
` Q. Okay.
` A. Actually, I can identify
`something else.
` Q. What else?
` A. They both have three atoms
`
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` DR. STEVEN MENCHEN, Ph.D.
`without the hydrogens.
` Q. Without what?
` A. Without the hydrogens.
`They both have three atoms.
` Q. Anything else?
` A. No.
` Q. Referencing column 26,
`please.
` And the paragraph at line 12
`through 30. 29, 12 through 29, do
`you have that in front of you?
` A. I see that.
` Q. And this is describing how
`one would synthesize the analogs; is
`that correct?
` A. We are on column 26?
` Q. Yeah.
` A. And line 12?
` Q. Actually, let me -- yes.
`Of Exhibit 1075.
` A. So this is written in the
`present tense so it is Ju's
`statement on how to make these.
` Q. In column 26 at line 12
`
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`

`Page 300
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`------------- I N D E X -----------
`WITNESS PAGE
`STEVEN M. MENCHEN, PH.D.
` By: Mr. Reines 6
`
`-------------- EXHIBITS ------------
`ILLUMINA FOR I.D.
` Exhibit 1091, U.S. Patent 58
` No. 6,111,116
` Exhibit 1092, '884 patent 152
`
` *** EXHIBITS ATTACHED ***
`
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`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

`[& - 2006-2007]
`
`&
`& 3:8,19 5:25
`1
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`143:22 144:9,13
`145:13 146:4,20
`147:6,14 148:12
`148:20 149:6,19
`150:11,14,15,18
`150:22 172:18
`173:2,4,19,23,25
`174:25 175:7
`176:10,17 180:18
`183:23 184:14
`195:3,12,13,14
`196:15 197:13,15
`198:7 199:6,20
`202:17,19 222:7
`223:17 224:19
`248:20 249:22
`250:23 251:7
`1,009 16:3
`10 155:16,20 163:2
`163:6,17 210:2
`100 124:7 125:16
`125:18,19,21,24
`126:5 228:4 230:8
`1001 150:9
`10076 242:24
`10104 3:13
`1016 190:21
`219:24
`102 184:17
`1021 33:6
`1023 271:18
`1037 124:25
`1075 46:13 100:6
`112:21 232:13
`1076 242:25,25
`263:14
`
`1091 58:10 300:9
`1092 152:14,17
`300:11
`10:04 43:3
`10:21 43:9
`11 156:15
`116 64:10 65:14
`68:6,17,21 69:11
`71:25 72:9 76:2,8
`78:19 83:7,15
`84:14 87:15 96:4
`96:21 97:6,18
`98:3 99:23 153:14
`153:25 154:18,25
`11:00 183:19
`11:11 94:20
`11:28 95:2
`12 112:10,11,19,25
`196:5,11 215:11
`232:18 233:4
`120 33:6
`12790 3:5
`1290 2:8 3:13 5:2
`12:17 135:13,16
`12:59 136:3,8
`13 139:22 196:5,12
`215:11
`14 1:19 2:2 4:4
`126:10,20 127:2,6
`129:17 130:15,20
`196:5,12 206:4,5
`206:11,21 210:13
`210:14,14 211:9
`215:11 234:16,18
`235:2
`15 131:21 263:18
`263:20,25 264:4,6
`264:14,21
`152 300:11
`16 155:20
`
`16th 299:21
`17 107:18 195:2,4
`195:9,19 245:13
`245:15
`18 107:2 108:17
`200:17 206:21
`245:14
`1985 31:7
`1989 40:3
`1990s 156:22
`218:24 219:3,6,10
`226:5,6 270:21
`271:14
`1994 35:8,15,24
`37:13 38:2,7,14
`39:10 116:14,20
`116:21,24 156:18
`164:25 166:24
`167:5 188:15,22
`190:22 191:10
`195:15 197:24
`211:5 219:23
`290:12
`1997-1998 60:17
`1998 65:15,15
`66:25 72:2,8 76:8
`78:20 83:12,16
`84:15 85:4 90:18
`97:8 98:18 99:14
`210:7 211:19
`212:15
`1998-1999 90:8
`91:10 92:7
`1999 90:18 115:5
`156:5 157:21
`160:16
`1:54 181:20
`2
`2 40:6 46:5 60:9
`66:9 81:15,17,18
`85:24 86:7,9
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`216:2 220:3,16
`230:15 231:17
`272:6 279:24
`2.5 223:18
`20 9:10 107:2
`113:16,17 114:7,8
`114:16 115:13,24
`115:24 131:18,19
`136:13 168:5
`193:12 222:12
`227:10 228:3,5,5
`228:14,16,22
`243:25
`2000 42:20 48:19
`117:10 118:6,22
`120:13 132:25
`134:9,17 137:14
`138:25 142:25
`145:20 147:18
`148:19 151:3
`168:21 188:21
`190:11 217:3
`236:6 237:4,18
`239:19 240:19
`279:14 285:5
`287:9,24 288:8,19
`289:6,22 295:11
`295:19,21 296:17
`296:19
`2006 20:16 23:11
`23:12 24:14
`146:14 148:13
`239:17
`2006-2007 24:25
`37:17 218:23
`
`800-642-1099
`
`David Feldman Worldwide
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`
`www.veritext.com
`
`

`

`[201 - 800]
`
`201 3:9 302:23
`2015 30:25
`2018 8:23 9:4
`2018-00291 4:22
`2019 1:19 2:2 4:4
`298:22 299:22
`2084 187:13
`21 136:12 139:21
`141:7 255:13,15
`255:20 256:3,11
`257:5,9
`2108 13:25 40:9,17
`40:19 41:6
`2114 8:14 9:24
`85:20 182:6 287:4
`2115 183:8
`22 130:12 267:17
`267:18 268:5
`24 121:14 156:17
`25 50:18,19,20,24
`59:3 100:9,12
`156:17 202:18
`203:2
`250 203:13 216:13
`216:19 217:3,9,25
`217:25 218:6
`222:11,12,22
`228:23 229:6
`230:18 231:3
`25th 8:23 9:4
`26 112:8,17,25
`114:14 115:14,24
`130:11 131:9
`232:14
`29 112:11,11 113:2
`121:15 186:10,12
`232:18 233:4
`2:12 182:2
`2:58 219:14
`
`3
`3 60:9,24 61:9
`63:19 64:12 65:3
`65:25 67:24 68:9
`69:19,24 70:15
`71:8 72:4,11
`74:23 76:11 78:22
`79:9 80:25 81:17
`81:18 82:5,16
`83:6,19 84:17
`85:4 87:4,13
`90:10,20 91:9
`92:9 93:18 95:5
`96:24 97:5 99:13
`99:22 102:2,8
`105:23 107:2,18
`108:17 109:9
`110:18 115:6
`116:7,16 117:2,12
`118:5,20,24
`119:20,24 120:18
`131:22,24 133:20
`144:15 145:12
`155:24 156:8
`162:9,20 163:16
`164:3,20 165:14
`166:3,19 167:7
`189:7,17 191:17
`191:25 196:4,6
`201:23 202:4,7
`233:21 234:6
`245:24 258:19
`259:19 265:4
`269:18 272:2,12
`273:5,14 274:16
`274:25 275:14,25
`276:20 277:17
`278:24 279:17
`292:20
`3'o 229:3
`
`3.7 265:6 266:16
`3.78 266:19
`30 112:11 226:9
`263:16,17 301:19
`31 263:17 264:2
`318 4:22
`322 4:22
`33 126:6
`34 150:16
`35 171:16
`385 4:22
`3:21 219:20
`3b 196:4,7,11
`198:25 204:15,16
`204:18,25 205:14
`205:21 215:10,13
`4
`4 106:8 201:12
`221:23 222:4,22
`223:10 226:11
`256:24
`40 59:10
`41 102:10 107:8
`4263 190:23
`43 155:25 163:5,22
`44 107:8 156:2
`163:22 266:9
`4:15 263:2
`4:32 263:8
`4a 223:19 224:4,16
`224:23
`4b 201:24 203:16
`204:5,8 212:18
`224:3,4 228:8
`4c 227:8
`5
`5 58:18,20 87:14
`87:20,25 95:15
`97:18 202:17,21
`222:9,14 223:18
`
`Page 2
`
`223:20 225:20
`256:24
`50/50 202:23
`500 170:12 226:12
`227:3,12,19 228:4
`228:9,23 229:9
`231:23 232:5
`5025 299:24
`51 95:17 186:13,16
`187:13
`54 107:3,19 108:17
`55 59:14,19 60:2
`58 87:24,25 264:11
`268:23 269:18
`300:9
`59 264:11 268:23
`269:18 271:21
`272:20,21
`5:00 297:5
`5:13 297:15,21
`6
`6 40:5 256:24
`300:5
`6,111,116 58:9,11
`300:10
`6.1 183:15,16
`65 141:7
`7
`7 41:20 50:18 51:8
`100:9 201:25
`202:2,19 227:8
`228:15
`76 182:7
`768 6:15
`797 4:22
`8
`8 202:15,21 203:16
`203:20 228:15
`800 228:17
`
`800-642-1099
`
`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

`[852 - allyloxy]
`
`852 150:10,18,22
`884 152:15,17
`154:18,24 155:6
`163:25 300:11
`9
`9 202:2,2 203:22
`203:23 204:4
`227:8 228:15
`234:2
`92130-2008 3:5
`93 122:8,21 123:11
`123:17 124:11,19
`94065-1175 3:9
`98 140:14,15
`985 46:14 100:4
`114:11 136:13
`143:22 146:7
`147:14 148:12,20
`149:6,18 171:11
`172:19 173:11
`174:25 175:8
`176:10,18 239:22
`240:14 248:20
`249:23 250:23
`251:7 252:25
`254:23
`99 126:4
`9:21 1:20 2:3 4:3
`a
`a.m. 1:20 2:3 4:3
`43:3,9 94:20 95:2
`aa 259:8
`abi 17:25
`ability 58:3 79:3
`able 130:24
`250:22 265:23
`284:23 285:7,12
`292:18
`absence 160:23
`
`absolutely 74:9
`ac 259:8
`accept 244:22
`accommodate
`265:4
`accomplished
`79:21
`accord 15:17
`accurate 12:5
`301:23
`accurately 139:8
`224:15
`acetylenes 185:22
`acid 61:21
`acknowledge 87:9
`109:14
`acknowledgment
`121:11
`acquisition 21:20
`acting 174:3
`active 202:20
`265:3 266:18
`activities 141:17
`actual 126:15
`127:18 195:15
`296:3
`actualities 296:4
`296:10
`add 33:2 223:5
`adding 98:24
`address 6:11,13
`162:16 250:15
`admit 54:20 63:8
`231:2
`advantage 66:14
`66:17
`affect 11:8
`afternoon 209:12
`ag 259:8
`ago 8:11
`
`agree 4:14 69:15
`69:22 115:4,17
`117:9,21 157:21
`187:25 222:20
`274:22 279:2
`280:23
`agreed 69:16
`158:4
`agreement 6:18,23
`agreements 26:5
`agrees 135:9
`ahead 189:25
`226:24 231:18
`alcohols 130:24
`alkamino 89:14,17
`alkoxy 63:23,25
`88:15
`alloc 246:4,5 248:4
`248:6
`allow 15:15
`259:20
`allows 169:21
`allyl 44:7,11 45:4
`46:7,17,21 47:3,10
`47:14,17 48:8,20
`49:15 50:2,8,14
`51:12,15,17,19,23
`51:24 52:4,5,14,17
`52:21 53:17 54:9
`55:3,6 90:7
`100:14,19,23
`101:2 103:9,12
`104:5,8,18 105:11
`109:11 110:5,9
`111:3 113:11
`114:22 115:5
`116:6,15 117:2,11
`118:4 119:23
`120:16 121:4,20
`122:7,19 123:9
`124:9,17 127:11
`
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`Page 3
`
`127:19 128:7,23
`129:8,25 131:10
`132:6,14 133:3,19
`134:8,21 141:13
`141:22 142:13
`143:15 144:14,16
`176:16 182:13
`188:7,16,24 189:2
`189:6,12,16 190:5
`190:13 191:11,24
`193:20 194:8,13
`194:20 220:5,9
`221:13,15,19
`232:20 233:6
`234:4 235:16,22
`236:25 239:7
`245:18,20,23
`246:22 247:13
`248:17 249:21
`250:21 251:5,19
`252:2,17,23
`253:16 254:14,25
`260:20 261:23
`262:9 272:4
`274:18 280:8
`281:20,22 282:13
`282:17,19 283:3
`283:16,21,24
`284:8,23 285:8,22
`287:24 290:7,14
`292:22 293:3,23
`294:13 295:8,25
`296:11,23
`allyloxy 43:12
`44:4,6,12,16 45:5
`45:19,23 46:4,8,18
`47:4,5,11,16,19,22
`48:9,11,16,21 49:6
`50:4,5,9 53:18
`54:10,23 55:4,7,9
`55:19,22 60:14
`
`www.veritext.com
`
`

`

`[allyloxy - art]
`
`63:19,24 64:2,5,11
`66:3 67:11,23
`68:8 69:4,17,23
`70:13 72:3,12
`74:11,22 76:5,10
`78:21 79:7 82:4
`82:15 83:5,17
`84:16 85:3 87:3
`90:4,11,21 92:8
`93:3,17 155:25
`156:6 162:19
`163:14 164:2,18
`165:3,8,13 166:2
`166:18 167:6
`allyloxycarbonyl
`247:25
`allyloxys 55:14,16
`60:19,23 61:8
`91:8 162:8
`allyls 246:3
`americas 2:8 3:13
`5:3
`amino 89:14,17
`amount 197:4,15
`197:21 198:2,3,5
`199:8,22 216:21
`216:24 217:4
`218:2,7,8 222:19
`222:21
`amplitaq 201:25
`202:16 226:23,23
`227:7,7,12
`amv 196:19,20
`analog 68:19 70:8
`79:23 80:6 97:20
`97:22 117:5,7
`177:13 272:3,13
`273:6,15 274:17
`275:2,15 276:2,21
`277:18 278:25
`
`analogs 55:13 59:6
`59:7,13,13,16,23
`60:3,6 62:20,20
`63:6,13 77:19,25
`97:17,23,24 98:15
`109:5 112:15
`113:4,8,25 117:6
`131:23 132:2,14
`133:3,19 155:17
`155:19 233:17,22
`258:16,24 259:8
`270:20 271:11
`analysis 159:15
`212:14 264:13
`265:8 268:22
`269:7,16,17
`270:15 277:2,5
`290:20 291:8,14
`292:3 294:10
`295:19
`analyze 281:22
`analyzed 151:22
`angstroms 265:6
`266:17
`anneal 260:11
`ans 294:25
`answer 15:16 22:2
`29:14 46:25 48:8
`53:14,22,23 67:19
`83:24 100:2
`105:17 123:2,5
`139:7 144:25
`151:16,23 153:5,7
`153:10 154:9
`159:12 166:6,16
`171:4,7,9,10 172:9
`224:14 244:19
`257:16 260:14
`266:10 278:14
`282:5,8 294:24,25
`
`answered 103:17
`108:3 149:9 181:5
`214:16 216:8
`225:18 240:2
`249:25 257:24
`287:13
`answering 54:4
`answers 151:8
`anybody 23:5
`anyway 54:20
`apologize 278:15
`appeal 1:3
`appearances 5:9
`application 57:15
`66:20 99:15
`106:18 109:4,25
`119:23 156:5
`160:2 223:16
`applications 62:3
`127:12 160:6
`applied 7:18 17:19
`18:13 19:4,13
`21:21 29:25 30:19
`31:5,8,24 36:22
`38:16 238:3
`241:14 242:7
`291:15
`apply 292:12
`appreciate 15:19
`approach 109:3
`109:24 136:16
`appropriate 11:17
`226:4 301:7
`approximately
`9:13,14 265:6
`aqueous 137:19
`138:14 260:6
`area 28:13 77:19
`77:25 96:23
`200:11 271:3,9
`
`800-642-1099
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`David Feldman Worldwide
`A Veritext Company
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`Page 4
`
`argument 55:10
`192:11 269:23,23
`art 29:7 30:18
`34:7,12,13,14 36:8
`42:20 48:18 63:11
`65:14 68:6,16
`70:2,7,19 71:25
`72:8 74:12 76:2,7
`78:19 83:15 84:14
`84:25 85:8 86:5
`86:13,23 90:15
`92:6 93:16 94:10
`97:7,13,20 98:18
`99:4,8,16,25
`102:22 105:24
`107:4,9,11,23
`108:5,15 109:17
`109:20 110:19,25
`114:23 118:12
`120:13,15 121:2
`122:4 126:16
`127:7,8 131:7
`132:4,25 133:16
`134:20 138:25
`139:10,16,18
`142:11,22 149:23
`157:4,22 158:18
`160:19 168:19
`175:7,14,24
`176:15 188:14,21
`190:11 217:3
`220:8 229:16
`232:4,17 233:3,12
`235:15,20 236:6
`240:12 251:16,21
`254:21 257:22
`258:11 259:16,17
`260:4,13,19
`261:13 262:7
`265:23 266:16
`284:21 285:6,16
`
`www.veritext.com
`
`

`

`[art - behalf]
`
`286:7,17 287:8,23
`288:8,18,23 289:4
`289:12,15 293:16
`294:17,22
`article 35:8,15,15
`35:25 38:14 39:2
`39:7,10 156:18,22
`162:11,18 164:11
`164:15 166:24
`167:6 190:22
`232:8 266:25
`articles 27:12 33:7
`aside 147:20
`194:18 249:15
`asked 25:17 29:19
`47:10 59:24
`103:16 108:2
`119:9,13,17 120:7
`127:13 132:18,19
`133:9,21 141:16
`149:9 173:9 179:3
`179:16,17,20
`180:22 181:5
`194:7 214:16
`216:8 225:17
`229:23 240:2
`249:25 254:10
`257:24 261:20
`281:24 283:9,11
`286:13
`asking 11:21 24:3
`30:12 31:19 51:5
`51:22 59:20 75:18
`105:5 119:15
`145:21 147:5
`148:9 163:12
`173:22 192:11
`221:11 224:9
`237:12 244:16
`247:5 250:9 251:3
`254:2 255:21
`
`800-642-1099
`
`277:8 295:6,7
`aspect 11:23
`assay 203:12
`214:6 216:12
`assigned 241:8
`242:15
`assignment 8:5
`122:18 143:20
`144:12 244:7,11
`assume 11:3,25
`25:5 72:2,11 76:3
`76:9 84:15 138:8
`207:6 229:20,23
`245:23,25 277:10
`281:6
`asterisk 213:19,24
`214:14 215:14
`216:2
`atlantic 183:5
`atmosphere
`184:22,24 185:2
`atom 43:20
`atoms 111:25
`112:5 231:12
`attached 298:13
`300:15 301:14
`attempt 58:4
`288:9 289:16
`attempted 68:21
`attempting 96:22
`108:16,20
`attention 18:23
`20:5 182:5 247:24
`attorney 301:18
`attorneys 3:4,12
`153:9 244:17
`282:7
`audio 4:11,12
`availability
`258:15
`
`available 265:2,14
`266:18,20,21
`avenue 2:8 3:13
`5:3
`aware 17:11,17,21
`17:24 19:19,25
`20:2,7 22:19
`26:19,21 33:14,18
`35:2,4,7 127:24
`128:5 149:14
`206:19 239:5
`252:6,9 270:17
`awareness 25:18
`29:6,23
`azidomethyl 272:5
`274:19 280:9
`289:5
`
`b
`b 123:23 196:8
`227:18
`back 23:10 33:4
`43:7 68:19 76:5
`94:24 95:7 100:4
`100:8 109:19
`126:19 130:10
`136:6 145:7 162:8
`181:24 182:5
`193:22,22 219:18
`228:25 229:3
`230:19 232:11
`234:10 235:12
`263:6 271:20
`278:9
`background 9:25
`10:7 106:13,19
`108:6,22 142:4
`backup 113:21,22
`bad 201:13 207:17
`216:11,17 297:12
`band 202:13,14
`203:5,7 210:16,17
`
`Page 5
`
`210:21,25 211:3,9
`211:11 212:23
`bands 196:25
`197:10,11 227:14
`base 16:15 59:23
`197:2 201:3
`241:17 268:7
`based 26:2 49:21
`51:25 53:4 59:8
`72:12 74:24 75:12
`76:12 78:23 79:2
`91:6,17 92:6
`117:23 127:16,22
`133:6,6,7,16
`141:23 143:10
`178:2 179:4 201:5
`206:23 208:18
`216:24 248:13
`249:17 252:5
`269:8,15 282:11
`282:25 286:4
`293:13,17
`basic 11:4 133:7
`133:17
`basically 107:14
`185:19 196:2
`207:3 210:8
`basing 74:13
`217:13 295:22
`basis 37:23 101:20
`151:17 152:9
`242:10 247:6,9,10
`249:5 250:4,8
`267:5 273:16
`277:11,11 281:6
`beckman 7:9
`began 36:16
`beginning 42:14
`238:13
`behalf 5:11,13
`
`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

`[belief - cartoon]
`
`belief 100:22
`206:25
`believe 35:11
`37:23 38:4,9,23
`52:3 65:10 71:17
`75:24 76:6 82:14
`83:3 99:12,21
`118:2 120:3
`158:21 187:3
`190:4 191:9 248:9
`271:15,17 280:14
`284:19 286:4
`296:12
`believed 70:13
`79:6 159:25
`benefit 289:25
`benson 58:14 75:2
`154:14 158:22
`best 8:7 9:8 12:5
`15:15 24:23 41:14
`46:25 58:3 86:16
`91:14,16 92:8,14
`92:16,18 93:10,13
`93:22 94:3 172:17
`172:25
`beta 267:8 268:6,9
`268:14
`beyond 7:4 79:16
`101:19 194:17
`208:15 218:14
`245:5
`bio 7:13
`biosystems 7:18
`17:19 18:14 19:5
`19:13 21:21 30:2
`30:19 31:5,9,24
`36:23 38:16 238:3
`birch 3:20 5:14,14
`bit 170:14 197:8
`262:19 278:19
`
`blocking 289:17
`290:14
`blood 299:16
`board 1:3 118:2
`bolded 187:20,22
`bond 66:8
`bonds 66:10,15
`95:6,13,20,21,24
`book 183:10,12,13
`bottom 51:2
`100:15 136:14
`226:11 245:15
`bound 30:11,13
`brackets 101:8
`break 42:24 94:18
`181:18 219:12
`258:12 262:22
`bring 25:16
`broadly 190:11
`191:10
`bunch 191:2,4
`butene 91:23
`butenyl 93:6
`butoxy 64:4 88:25
`89:6 91:20
`c
`c 3:2 6:4 131:12
`136:4 226:20,21
`243:23 245:6
`246:6,12 248:7
`264:20 275:18
`280:4
`calculated 274:21
`calculations 275:8
`275:22
`california 3:5,9
`6:16
`call 43:23 44:7
`48:15 51:24 89:21
`123:19,23,25
`203:4,6 211:2,10
`
`261:3
`called 6:5 19:9
`66:3 95:13 212:20
`calling 49:15,19
`87:24 212:22
`220:21
`calls 51:18,23
`189:10,12
`camino 3:5
`candidate 64:17
`64:20 67:11,24
`69:18,24 70:14
`71:5 72:4,10,24
`73:7,15,25 74:14
`74:22 75:10 76:10
`78:21 79:7 83:5
`83:18 87:3,13
`95:4 99:12,21
`156:7 162:20
`163:15 164:3,19
`165:14 166:2
`191:25
`candidates 65:7,9
`65:17 66:4 70:22
`71:14 76:4 90:10
`90:20 91:9,13,14
`91:16 92:9,14
`93:11,13 95:24
`97:4 155:23 162:9
`192:7 240:6
`277:16 278:2
`cap 102:13 104:8
`111:11 117:2,12
`118:20 119:24
`132:6 134:4 234:5
`234:6 258:18
`capable 160:12
`240:23
`capped 109:9
`131:22,25 191:2
`196:13,14,17
`
`Page 6
`
`197:9 218:18
`233:21 265:5
`capping 60:24
`104:4,6,15,19
`105:9,11 115:6
`116:7,16 118:4
`119:19 138:2,15
`139:12 142:24
`144:14 145:11
`146:2,19 147:12
`147:24 148:10,17
`149:6,18 150:21
`162:21 166:19
`167:7 193:25
`194:3 240:14
`245:18 246:23
`247:14 248:18
`251:8 254:14
`258:18 259:18
`260:20 261:4,24
`262:10 272:2,12
`273:5,14 274:16
`274:25 275:14,25
`276:20 277:17
`278:24 279:18
`281:23 282:13,17
`282:19 283:3,16
`284:23 285:8,22
`286:18 287:9,25
`288:16 289:5
`293:4,24 294:14
`295:10 296:2,12
`296:24
`caps 233:16 239:7
`capture 99:3
`carbon 43:20
`careful 29:20
`carefully 200:13
`301:5
`cartoon 195:17,18
`195:24,25 200:17
`
`800-642-1099
`
`David Feldman Worldwide
`A Veritext Company
`
`www.veritext.com
`
`

`

`[cartoon - comes]
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`206:4,12,21 210:3
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`case 7:9,13 16:20
`52:3 53:5 144:8
`179:5 248:14
`249:18 253:14
`255:23 256:7
`286:5 292:13
`catalyst 184:19
`186:2
`caution 67:15
`cellphones 4:8
`certain 207:17
`certainly 32:5
`129:19 274:4
`certify 298:9
`299:9,15
`ch2 109:12
`ch2ch 109:11
`ch2och3 109:11
`chain 109:12
`235:7
`challenge 249:6
`250:9
`chance 270:9
`change 205:16
`227:17 302:9,11
`302:13,15,17
`changes 301:13
`302:5
`channel 206:20
`characterization
`122:12,22 127:6
`characterizing
`23:22 49:2 124:20
`158:17
`checked 141:4
`chemical 16:14
`73:7 87:18 88:7,8
`88:11,13,16 89:12
`100:19 101:9
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`800-642-1099
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`102:24 103:13
`110:5,10 111:6
`118:14 121:4,19
`147:22 171:19
`240:23 258:17
`chemically 109:9
`111:14 120:17
`130:13 171:18
`173:25 234:15
`236:24 240:23
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`107:12 130:23
`chemistries 65:25
`75:11
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`43:19 65:5 66:3
`72:25 73:15 74:2
`74:24 79:10,23
`80:7 81:12 93:23
`97:20 118:22
`123:22 134:8,20
`155:3 156:9
`185:20 191:12
`chen 3:21 6:2
`chloride 182:14,16
`circumvent
`186:19,22,25
`187:6,9 192:22
`citation 10:13
`citations 130:19
`cite 161:25 211:22
`cited 10:10 13:8
`13:10 157:8,17
`277:3
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`citing 156:25
`160:18
`city 1:9 4:21
`claim 143:22
`144:9,13 145:13
`146:4,20 147:6,14
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`148:12,20 149:6
`149:19 150:11,14
`150:15,18,22
`172:18 173:2,4,19
`173:23,25 174:9
`174:25 175:7
`176:10,17 180:11
`180:18 181:2,13
`248:20 249:22
`250:23 251:7
`claimed 235:23
`239:8,21 240:15
`247:16 252:24
`254:8 277:5 283:5
`288:2 296:24
`claims 151:24
`173:14 177:2,3,21
`178:13,24 179:11
`179:12,15 180:12
`181:3,14 240:25
`clarification 13:21
`clarify 73:4
`cleaner 278:20
`clear 35:13 52:22
`152:20 263:24
`clearly 293:15
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`109:6,10 171:19
`174:2
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`122:6,19 123:9
`124:9,16 132:20
`139:11 149:23
`236:3,8 254:19,22
`260:10 284:5
`293:17
`cleave 235:16
`261:10 292:18,18
`cleaved 111:14
`125:11 283:22,25
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`David Feldman Worldwide
`A Veritext Company
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`Page 7
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`cleaving 236:25
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`clr 299:25
`coach 274:5
`coaching 23:25
`49:3 273:23 274:7
`colleagues 61:24
`columbia 1:8 3:20
`3:21,21 4:20 5:21
`6:3 8:13 13:24
`columbia's 246:21
`column 50:24 51:6
`58:17,20 87:14,20
`87:25 95:15 97:18
`102:2,8 105:23
`106:8,13,25
`107:18 108:17
`112:8,17,25
`114:14 115:14,23
`115:24 130:11
`131:8 136:12,13
`139:21 141:6
`150:16 155:16,20
`156:14 163:2,6,17
`171:16 210:13,14
`232:13 255:12,14
`255:20 256:2,11
`257:5,9
`combine 290:19
`290:25 291:2,7
`293:19
`come 14:4 64:21
`65:25 86:17 90:3
`95:23 189:5
`191:23 192:11
`211:22 285:25
`comes 108:19
`245:22 294:21
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`www.veritext.com
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`[comfortable - conversation]
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`comfortable 49:14
`49:19 69:7,10
`209:17,23
`coming 67:8 93:8
`198:22 249:19
`comment 142:17
`143:5 149:10
`159:3 165:10
`176:13,22 225:2
`231:25 270:5
`commercially
`266:21
`commission
`302:25
`common 231:11
`259:12,14,15
`commonality
`111:5,9
`communicating
`295:15
`company 25:2
`183:6
`compared 66:9,15
`177:15 222:20
`compatible 236:4
`236:9 261:11
`competency 94:9
`133:7,17
`competing 169:14
`complete 15:15
`202:12 228:18,24
`229:6 230:17
`completely 80:17
`compound 79:4
`96:11 103:7
`116:19 123:22,23
`125:4,6 147:22,23
`149:4,16 172:12
`188:12 199:3
`220:3,10,17 229:5
`280:5
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`800-642-1099
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`compounds 45:5,6
`45:8,15 146:14
`163:7 165:2,22
`168:4 198:11
`199:16,18 277:25
`concentration
`201:22 202:8
`204:10,19,25
`205:7,22,23 207:2
`207:17 208:14
`216:14 217:12
`225:6 226:3 227:4
`228:9,20 230:24
`concentrations
`205:17 225:3,21
`229:18 230:3
`232:6
`concept 159:7
`concerned 21:3,6
`conclude 22:9
`78:20 235:20,24
`concludes 297:16
`concluding 242:10
`conclusion 20:25
`26:10,14 27:17
`82:20 83:9,22
`84:22 144:23
`146:24 147:8
`148:24 149:12
`150:25 159:11,19
`161:16 174:20
`213:15 241:6
`248:25 250:3
`251:2 253:6,20
`279:23 290:22
`conclusions 18:14
`18:17 29:2 38:14
`38:25 39:19
`conditions 235:8
`235:17 236:3,8,17
`236:21,22,24
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`237:2,7 239:6
`254:20,22 260:6
`293:17
`confidence 146:18
`148:16
`confident 48:13
`confidential 6:21
`25:14,15 27:16,19
`27:21 28:5,16
`30:5 35:12,17
`37:21,23
`confidentiality
`26:5 30:11,14,23
`38:10 237:21
`confirm 8:21
`101:5 264:18
`confused 224:18
`connection 22:6
`22:20 23:14 24:14
`25:22
`connects 16:15
`241:16
`consider 14:11
`15:3 21:18 29:9
`30:13 31:9 35:16
`40:15 41:5 72:23
`73:5,10,14,24 77:4
`77:11 93:9 159:18
`174:16 199:21
`222:14 243:22
`253:15 255:23
`256:8,12 267:14
`268:17 269:9,24
`considered 14:2,5
`14:20,20 15:8
`30:3 33:5 40:8
`83:11 153:13,24
`221:6 254:2 255:9
`256:13,