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`IMMANUEL FREEDMAN, Ph. D, SMIEEE, MInstP, CPhys
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`SUMMARY OF EXPERIENCE
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`Systems, Signals and Algorithms Consultant with over 30 years experience of video,
`imaging, modeling, simulation, and systems analysis, design, development and testing. He has
`served as expert consultant providing technical analysis related to patent infringement, patent
`validity, and the research tax credit.
`
`EDUCATION
`Ph. D., Physics, University of Durham, England, 1986
`B.Sc. (Honors), Physics, University of Durham, England, 1979
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`LICENSES
`Registered Patent Agent #51,704
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`EXPERIENCE
`State University of New York at Buffalo Buffalo, NY June ’17-present
`Research Scholar (Volunteer)
`
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`Freedman Patent
`Sole Proprietor
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`He provides expert consultant and expert witness services to industry and the legal
`profession.
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`Dr. Immanuel Freedman, Inc.
`President
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`He provided technical consultant services to industry.
`
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`GlaxoSmithKline, Inc.
`Manager, Clinical Pharmacology
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`Dr. Freedman provided mathematical modeling of systems, signals and images and,
`participated in technical due diligence activities on demand.
`
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`Merck & Co., Inc.,
`Senior Research Fellow
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`Dr. Freedman provided mathematical models on demand.
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`Upper Merion, PA
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`Aug ‘02-present
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`Mar ‘96-Jan’ 16
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`Aug ‘07-Jun ‘16
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`Nov ’04-Jul ‘05
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`Harleysville, PA
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`Harleysville, PA
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`West Point, PA
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`Page 2.
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`Apr ’03-Mar ‘04
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`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`Amgen, Inc.
`Thousand Oaks, CA
`Contractor
`
`Dr. Freedman developed algorithms and software in MATLAB and FORTRAN for
`simulation and data modeling.
`
`Cyra Technologies, Inc.
`Senior Hardware Engineer
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`Dr. Freedman designed, developed, and tested algorithms and software for calibrating a
`three-dimensional laser scanner. He calculated the statistical distribution of outcomes for an
`engineering tolerance stack by modeling and simulating the scanner response using a Jacobian
`sensitivity matrix to compare alternative placements of scanner calibration targets based on a D-
`matrix of scanner response.
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`Media Logic Systems Ltd.
`Chief Systems Engineer
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`Dr. Freedman designed and developed a novel live interactive television systems
`(iSeeTV) in which customers communicate with human sales agents in video-enabled call
`centers via television and telephone, deployed to 50,000 subscribers of Telewest, UK.
`
`He researched and developed tools and encoder systems to optimize image quality at
`prescribed latency and bit rate for distributing live video and audio streams encoded via low
`latency methods including MPEG-2 Simple Profile at Main Level (CATV), MPEG-4 Visual
`Profile with background sprite coding, and H.263+ (now known as H.264).
`
`Dr. Freedman investigated the feasibility of wavelet–based software encoding schemes
`with motion compensation and perceptual quantization described by the MPEG Standards
`Committee Interframe Wavelet Ad Hoc Group. He interfaced video streams via ATM transport
`to Telewest, UK regional CATV head-ends switched via Harmonic Narrowcast Gateways for
`distribution via Video On Demand or Near Video On Demand systems to customer's homes.
`
`Replay Networks, Inc.
`Contractor
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`Dr. Freedman researched and developed a method of porting an application developed for
`a Digital Video Recorder in the embedded C software language to standard set top box (STB)
`middleware to eliminate high development and maintenance costs associated with developing
`custom STBs. He optimized bit rate and encoder chip parameters to yield high-quality time-
`shifted MPEG-2 streams controlled by VCR-like consumer controls.
`
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`Sun Microsystems, Inc.
`Software Engineer (Contractor)
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`Dr. Freedman researched and developed a Distributed Component Object Model
`(DCOM) software interface between a TV Control Graphical User Interface and the Microsoft
`Broadcast Application Programming Interface (API) to improve the visual quality of interactive
`TV displays derived from UDP/IP datagrams synchronized with MPEG-2 audio/video packet
`data. The software interface additionally resolved discontinuities in Presentation Timestamp
`according to a Normal Play Time defined by a Digital Storage Media –Command and Control
`standard.
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`San Ramon, CA
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` Nov ’02-Apr ‘03
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`Fleet, England UK
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`Jan ’00-Oct ‘02
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`Mountain View, CA
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`Dec’99-Jan ‘00
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`Cupertino, CA
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`Mar ’99-Nov ‘99
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`Mitek Exhibit 1004, Page 002
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`Page 3.
`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`He designed and implemented an API written in the pJava and Visual C++ software
`languages under the Windows CE operating system for the Motorola DCT 5000+ DTV Set Top
`Box based on the Advanced Television Systems Committee digital television standard.
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`
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`Rockwell Collins, Inc.
`Lead Systems Engineer (Contractor)
`
`As Lead Systems Engineer with a two-engineer span of control, Dr. Freedman timely
`delivered harmonized requirements for an MPEG-2 in-flight entertainment system similar to a
`cable television system based on an advanced intranet implemented on an aircraft.
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`He trained his team to use a Rational Unified software development process based on a
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`Spiral Development Model implemented in the Universal Modeling Language using the
`Rational/Rose 98i Computer Aided Software Engineering tool.
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`Stratagene, Inc.
`Engineer (Contractor to Permanent)
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`Dr. Freedman evaluated frame grabber hardware for resolution and quality of time-
`integrated imagery, and specified algorithms including cluster analysis and trending for a digital
`image processing system supporting gene-cloning science.
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`United Advanced Technologies, Inc.
`Firmware Engineer (Contractor)
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`Dr. Freedman analyzed and developed a nine-camera remote surveillance system with a
`Graphical User Interface developed in the Visual C++ software language under a Microsoft
`Windows operating system host and firmware developed in the embedded C software language
`implemented on Analog Devices' ADV601 wavelet video hardware.
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`He researched and developed Video for Windows parameters and on-chip settings for
`video quality control to deliver full-frame video over Plain Old Telephone Service telephone
`lines at quality acceptable to retail store security services.
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`KeyInfo Services, Inc.
`Database Consultant
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`Dr. Freedman administered a database for providing web-based information developed in
`the Sybase SQL software language.
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`Mitek Systems, Inc.
`Engineer (Contractor)
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`Dr. Freedman researched and developed an Intelligent Character Recognition digital
`image processing system based on neural nets implemented in the C software language to read
`handwritten checks and paper forms with about 80% accuracy on a real-time system deployed
`throughout the banking industry.
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`He researched and developed algorithms based on mathematical morphology
`implemented via neural nets to verify handwritten signatures on printed checks.
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`Spring Valley, CA
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`La Jolla, CA
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`Long Beach, CA
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`San Diego, CA
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`Pomona, CA
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`Oct ‘98-Mar ‘99
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`Aug ’98-Oct ‘98
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`Feb ’98-Aug ‘98
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`Mar ’98-May ‘98
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`Aug ’97-Jan ‘98
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`Mitek Exhibit 1004, Page 003
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`Yorba Linda, CA
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`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`Symbionics Ltd.
`Cambridge, England UK Aug ‘97
`Principal Engineer (Temporary)
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`Dr. Freedman analyzed manpower estimates for design, development and testing of an
`MPEG-2 interactive television set-top box based on an OpenTV interactive television standard
`implemented for the "Open…." television commerce system deployed Spring 1999 in the United
`Kingdom.
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`VideoActive/HCR, Inc.
`Contractor
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`Dr. Freedman reviewed, analyzed and developed proprietary disk layout software coded
`in the Visual C++ software language for a Near Video on Demand system delivering movies
`over telephone systems such as Asymmetric Digital Subscriber Lines (ADSL).
`
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`Anugraha
`Sole Proprietor
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`Dr. Freedman researched and developed algorithms and processes to compress fine art
`photography at image quality acceptable to artists based on the JPEG imaging standard
`implemented with image pre-processing and adaptive quantization.
`
`Armor Safe Technologies, Inc.
`Firmware Engineer (Contractor)
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`Dr. Freedman developed an ARINC RS422/RS485 serial link communications software
`component written in the embedded C software language for a major confidential client
`specialized in retail store security. His timely software delivery enabled the client to capture a
`firm order with additional future potential.
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`
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`Comstream, Inc.
`Firmware Engineer (Contractor)
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`Dr. Freedman integrated a MPEG-2 set top box with OpenTV interactive television
`middleware programmed in the Microtec C language ported to a Motorola 68340 processor
`under the pSOS operating system.
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`General Instrument, Inc.
`Senior Staff Engineer
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`Dr. Freedman reviewed and evaluated methodologies, design and development and
`performance models for the DigiCipher 2 cable television conditional access system. He
`migrated a subscriber authorization system written in the C++ language from a DEC Alpha
`computing platform under the OpenVMS operating system to a Sun SPARCstation computing
`platform under the Solaris operating system.
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`Optivision, Inc.
`Consultant
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`Dr. Freedman researched and developed rate control algorithms and software based on
`MPEG -2 Test Model 5 for the OPTIVideo MPEG-2 video encoder written in the Visual C++
`and C software languages.
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`Page 4.
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`Jan ’97-Dec ‘97
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`Jan ’96-Jan ‘97
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`Sep ’95-Mar ‘96
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`Jul ’96-Aug ‘96
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`Dec ’95-May ’96
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`Mar ’95-Sep ‘95
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`La Jolla, CA
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`Vista, CA
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`San Diego, CA
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`San Diego, CA
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`Davis, CA
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`Mitek Exhibit 1004, Page 004
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`

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`Jul ’94-Jan’95
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`Sep ’88-Jun ‘94
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`Page 5.
`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`He researched and developed adaptive quantization algorithms based on a JPEG-3 draft
`standard for possible inclusion in the draft National Imagery Transmission Format imaging
`standard.
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`He researched and developed algorithms to improve the quality of gray scale image
`compression for the medical imaging DICOM Standard by providing a lossless hybrid algorithm
`encoding image residuals with a diagonal Golomb code based on an Enhanced Universal Trellis
`Coded Quantization algorithm.
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`Federal National Mortgage Association Washington, DC
`Software Engineer (Contractor)
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`Dr. Freedman designed and developed a Graphical User Interface to monitor and validate
`loan servicer input for the Loss Mitigation Project. He developed the software in the C software
`language for a Sun SPARCstation 2 platform under a UNIX operating system.
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`Hughes STX Corporation
`Senior Systems Engineer
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`As Spacecraft and Attitude Analyst for a mission to map the relict radiation from the Big
`Bang at near infrared, far infrared and microwave wavelengths, Dr. Freedman developed,
`simulated and calibrated the Cosmic Background Explorer (COBE) Attitude Determination
`System to yield a stable solution for the spacecraft orientation at a quality factor of 2 above
`customer’s expectation. This solution included a quaternion estimator implemented via an
`Extended Kalman Filter.
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`He developed, calibrated and simulated the COBE spacecraft subsystem and provided
`graphical and statistical analysis of the spacecraft telemetry-word database. When a gyroscope
`failed during the Launch and Early orbit mission phase, he responded rapidly by plotting graphs
`of the thermal subsystem telemetry until he found a possible cause of failure.
`
`Dr. Freedman developed a spatially referenced database based on a quad-tree data
`structure, which stored scientific data for comparison of sky maps from COBE with sky maps
`from other missions.
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`For the COBE mission, he led the systems engineering and end-to-end development of a
`novel system for compressing data that combined scientific modeling with statistical data
`compression. He proposed the system concept and prepared the system level specification,
`design and project schedule. With a team of two engineers, Dr. Freedman tuned the compression
`system performance to yield a throughput greater than uncompressed data processing with a
`compression factor of 22-90%. He further designed and developed evaluation tools to ensure the
`user- transparent system-wide compression of a 380GB dynamic data base at image quality
`acceptable to scientists.
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`University of Maryland
`Research Associate
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`Dr. Freedman researched and developed digital image methods to process terrain models,
`developed in the C software language for a super computer under a UNIX operating system.
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`He designed low-complexity algorithms for filtering, segmenting, clustering, and path
`planning based on digital images organized by quad-tree data structures.
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`College Park, MD
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`Greenbelt, MD
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`Jun ’87-Sep ‘88
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`Page 6.
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`Sep ’86-Jun ‘87
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`Nuneaton, England UK
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`Nov ’82-Sep ‘84
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`Cambridge, England UK Sep ’85-Sep ‘86
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`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
`
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`University College London
`London, England UK
`Research Assistant
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`Dr. Freedman developed digital image processing algorithms to improve image and
`stereo-matching quality for a digital terrain modeling system based on satellite data. As part of a
`UK Government Fifth Generation computing project (Alvey MMI-237) in collaboration with
`Thorn EMI, Royal Signals and Radar Establishment, and Laser Scan Ltd., he developed software
`and algorithms for affine transformation, edge filtering, kriging interpolation and image stereo
`matching with sub-pixel acuity.
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`Laser-Scan Ltd.
`Software Engineer
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`Dr. Freedman researched and developed algorithms based on the mathematics of
`tessellation for efficient manipulation of spatially referenced data on serial computers and
`transputer arrays for a UK Government Fifth Generation computing project (Alvey MMI-237) in
`collaboration with Thorn EMI, Royal Signals and Radar Establishment, and Laser Scan Ltd.
`
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`National Coal Board
`Scientist (Management Grade 7)
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`For a Health and Safety project, Dr. Freedman developed and validated a microcomputer
`system to detect coalmine fires and heatings. Based on stochastic and temporal analysis of
`infrared data obtained via a tube bundle system, and telemetry data from underground
`thermocouples, the system detected growing trends of Carbon Monoxide concentration in the
`presence of noise from underground events such as blasting, diesel engine fumes, ventilation
`changes, and seismic activity.
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`PUBLICATIONS
`Wilkins, J. et al. (2019), ISoP Position Statement on “Guidance Document: Population
`Pharmacokinetics: July 2019”, Docket No. FDA 2019-D-2398
`
`Freedman, I. (2019), "Chaos Synchronization: Identifying & Predicting Noisy Complex
`Systems," in AAPS Forum to Connect Predictive Modelers, May 6-7, 2019 Boston MA
`
`Pillai, N. et al. (2019), “Estimating parameters of nonlinear dynamic systems in
`pharmacology using chaos synchronization and grid search,” Journal of Pharmacokinetics and
`Pharmacodynamics, 46(2), 193-210
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`van Oordt, C. W. M. H et al. (2019), "ImmunoPET imaging to assess target engagement:
`Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors" , J Nucl
`Med jnumed.118.214726 published ahead of print February 7, 2019
`
`Norris, D. et al. (2018), “Expansion Cohorts: Use in First-In-Human Clinical Trials To Expedite
`Development of Oncology,” submitted to FDA, FDA-2018-D-2777-0001, DOI
`10.17605/OSF.IO/NMGH8
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`Freedman, I. (2018), “IEEE Digital Health Standards,” at FIS Global , November 27, 2018,
`Collegeville:PA
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`Mitek Exhibit 1004, Page 006
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`Page 7.
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`
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`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`Freedman, I. (2018), “Chaos Synchronization: Estimating Parameters of Noisy Complex
`Systems,” in IEEE Section Night, October 20, 2018, Philadelphia:PA
`
`Schieke, M. & Freedman, I. (2018), “3D Topological Mapping of Macroanatomy and
`Microanatomy for Use in Big Data and Augmented Intelligence Systems,” in IEEE-Standard
`Association Workshop on Digital Health Standards, September 11, 2018, Atlanta:GA
`
`Freedman, I.(2018), "The Intellectual Heritage of Babylonian Astronomy: Music of the
`Spheres," in Rencontre Assyriologique Internationale 64, July 14-20, 2018, Innsbruck Austria
`
`Pillai, N. et al. (2018), "Chaos synchronization and Nelder-Mead search for parameter
`estimation in nonlinear pharmacological systems: estimating tumor antigenicity in a model of
`immunotherapy," PBMB Special Issue Volume 139, November 2018, Pages 23-30
`
`Pillai, N. et al. (2018), "Estimating parameters of chaotic systems: chaos synchronization
`combined with Nelder-Mead search, " in PAGE 2018: May 31, 2018, Montreux CH
`
`O'Connor, M. A. et al. (2017), "Elucidating Exposure-Response (Safety and Efficacy) of
`Adct-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Containing Antibody
`Drug Conjugate, for Recommended Phase 2 Dose Determination in Patients with Relapsed or
`Refractory Non-Hodgkin Lymphoma," in American Society of Hematology 59th Annual
`Meeting & Exposition, Atlanta GA Dec 9-12, 2017
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`Freedman, I., Bies, R. R., Pillai, N., Schwartz, S., Ho, T. (2017), "Estimating parameters of
`chaotic systems in pharmacology", invited talk in American Conference on Pharmacometrics 8,
`Oct 14-19, 2017, Ft. Lauderdale:FL
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`Nguyen, T-H-H et al. (2016), Model evaluation of continuous data pharmacometric models:
`metrics and graphics, CPT Pharmacometrics Syst Pharmacol. 2017 Feb; 6(2): 87–109
`
`Freedman, I., Bies, R. R., Pillai, N. (2016), “Estimating parameters of chaotic systems,” in
`American Association of Pharmaceutical Scientists Annual Meeting and Expositions, November
`13-17, 2016, Denver CO
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`Freedman, I.(2016), "Babylonian astronomers predicted lunar and planetary positions using
`iterated maps, forerunners of deterministic chaos," in Rencontre Assyriologique
`Internationale 62, July 11-15, 2016, Philadelphia PA
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`Cataloluk, O. & Freedman, I. (2016), "The meaning of armannu," in Rencontre
`Assyriologique Internationale 62, July 11-15, 2016, Philadelphia PA
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`Freedman, I., Bies, R. R., Ho, T. (2015),“Estimating parameters for chaotic systems,” in
`GlaxoSmithKline Biostatistics Annual Conference, November 13, 2015, Upper Providence PA
`
`Freedman, I. (2015), “A QSP model for cancer incorporating HER-3,” in GlaxoSmithKline
`Quantitative Systems Pharmacology Day, October 29, 2015, Upper Merion PA
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`Mitek Exhibit 1004, Page 007
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`Page 8.
`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`Freedman, I. (2015), “Imaging & Microdialysis: Complementary Modalities?” invited panelist,
`in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, October
`24-29, 2015, Orlando:FL
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`Freedman, I. (2015), “On MA.NA EN.NUN in mul APIN,” NABU 2015-2 Nr. 50
`
`Freedman, I. (2015), “The Marduk Star Nēbiru,” Cuneiform Digital Library Bulletin 2015:3,
`retrieved from http://cdli.ucla.edu/files/publications/cdlb2015_003.pdf
`
`Freedman, I. (2015), “Short Note: On an Assyriological Interpretation of the Book of Daniel
`5:1–28,” Journal of Translation 11(1), 74
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`Bies, R. R., Ho, T. & Freedman, I. (2015), “Nonlinear dynamic physiological systems: Chaos
`Synchronization as an approach to parameter estimation” in Kinetic and Dynamic Complexity in
`Drug Transit-Response in the Human Body, satellite meeting to Population Approach Group
`Europe 2015, June 2, 2015, Hersonissos:GR
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`Freedman, I. (2015), “On an Assyriological interpretation of Constantine’s labarum” retrieved
`from http://www.researchgate.edu
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`Freedman, I. (2015), “Model Evaluation and Selection,” invited talk to American Association of
`Pharmaceutical Sciences Pharmacometrics Focus Group, March 26, 2015
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`Freedman, I., Moyer, B.R & Cheruvu, N.P.S. (2014), “Pharmaco-Imaging”, in American
`Association of Pharmaceutical Sciences Translational Sciences 101 e-learning course, retrieved
`from http://www.aaps.org/TS101/
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`Freedman, I. (2014), “Role of Pharmacology in Anti-Cancer Antibody Development,” invited
`talk, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Nov
`2-6, San Diego:CA
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`Willis, S. et al. (2014), “Martha Meets Shakespeare,” musical performance, retrieved from
`http://www.youtube.com/
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`Austin, D., Freedman, I., Grove, R, Tolson, J. & Vanmeter, S. (2014), "The Relationship
`Between Peripheral B-Cell Levels and MRI Disease Activity in Relapsing-Remitting Multiple
`Sclerosis (RRMS)", dual presentation in American Academy of Neurology 66th Annual
`Meeting, Philadelphia:PA
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`Freedman, I. (2014), “On horses and bitumen in mulAPIN,” NABU 2014-1 Nr. 33
`
`Freedman, I. (2014), "Pharmaco-Imaging in Translational Science and Research," in Pharmaco-
`Imaging in Drug and Biologics Development (Moyer, B.R., Cheruvu, N.P.S. & Hu, T. C.-C.,
`eds.), Springer, Inc.
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`Mitek Exhibit 1004, Page 008
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`Page 9.
`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`Freedman, I. & Bies, R. (2013),"Chaos Synchronization," invited talk, in 3rd Annual Indiana
`Clinical and Translational Sciences Institute Symposium on Disease and Therapeutic Response
`Modeling, Nov 5-6, 2013, Indianapolis, IN
`
`Freedman, I. (2013), “Translational pharmacometric models of anti-cancer antibodies,” invited
`talk, in 2nd International Conference on Translational & Personalized Medicine, Aug 5-7, 2013,
`Chicago IL
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`Freedman, I. (2013), “Writing on the Wall–Conspiracy in Babylon?” retrieved from
`http://www.researchgate.edu
`
`Willis, S. et al. (2013), “Amy’s Suite,” musical performance, retrieved from
`http://www.youtube.com/
`
`Freedman, I. (2012), “Translational Imaging and Pharmacometrics for CNS,” invited talk, in
`GCTbio 3rd Pharmacokinetics/Pharmacodynamics Conference, Oct 24-26, 2012, Philadelphia:PA
`
`Freedman, I. (2012), “Translational Imaging and Pharmacometrics for CNS,” invited talk, in
`American Association of Pharmaceutical Scientists Fall Meeting and Exposition, Oct 14-18,
`2012, Chicago:IL
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`Freedman, I. (2012), “Case Studies in the Use of Imaging Agents in Proof-of-Concept and Early
`Proof-of-Efficacy Trials,” invited talk, in National Biotechnology Conference, May 21-24, 2012,
`San Diego:CA
`
`Freedman, I. (2012), “Regulatory Opportunities and Hurdles with Imaging Agents in the Era of
`Personalized Medicine,” invited panelist, in National Biotechnology Conference, May 21-24,
`2012, San Diego:CA
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`Freedman, I. (2012), “Translating Clinical and Pre-Clinical Information into Success,” invited
`talk, in Hanson Wade 3rd World PK/PD Summit, March 27-29, 2012, Boston:MA
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`Freedman, I. (2012), “Improving Integration of PK/PD Modeling into the Drug Development
`Process,” invited panelist, in Hanson Wade 3rd World PK/PD Summit, March 27-29, 2012,
`Boston:MA
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`Derosier, F.J. et al. (2012), “Novel Uses,” WIPO Publication WO2012096924 A1, priority date
`Jan 10, 2011
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`Freedman, I. (2011), “The Impact of 3D Tissue Models on Drug Development and Predictive
`Safety,” invited panelist, in Predictive Functional Tissue Models, November 17-18, 2011,
`Boston:MA
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`Freedman, I. (2011), “System for forecasting outcomes of clinical trials,” United States Patent
`Application Publication 20110238317A1, priority date Aug 9, 2007.
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`Mitek Exhibit 1004, Page 009
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`Page 10.
`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`
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`Freedman, I. (2011), “Case Study–Optimizing Design of a Phase 2 Clinical Trial in Relapsing-
`Remitting Multiple Sclerosis,” invited talk in Joint Statistical Meetings 2011, Miami FL July 30-
`August 4, 2011
`
`Freedman, I. (2011), “Case Study–Bridging from Western to East Asian Population in
`Accordance with ICH E5,” in American Conference on Pharmacometrics 2011, San Diego CA
`April 3-6, 2011
`
`Larkin, J. et al. (2010), “Osteoarthritis Disease Modification Potential of GSK2394002” in
`GlaxoSmithKline Clinical Pharmacology Symposium, Philadelphia PA June 15, 2010
`
`Larkin, J. et al. (2010), “ADAMTS-5 Neutralizing Monoclonal Antibody: Translational
`Pharmacology Approach Provides Reason to Believe,” in GlaxoSmithKline Clinical
`Pharmacology Symposium, Philadelphia PA June 15, 2010
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`Freedman, I et al. (2009), “Bayesian Parametric Schild Analysis from a Whole Blood
`Stimulation Assay,” in American Conference on Pharmacometrics 2009, Mystic CT October 4-7,
`2009
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`Freedman, I. (2009), “Feasibility of Immunogenicity Assessment based on Models of Polyclonal
`Anti-Drug Antibody Immunodynamics,” in American Conference on Pharmacometrics 2009,
`Mystic CT October 4-7, 2009
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`Austin, D. J., et al. (2008), “Translational Pharmacology from a Domain Antibody First Time in
`Human Study,” in SciNovations Symposium, Verona IT, September 26, 2008
`
`Freedman, I. (2007), "Video Compression," in The Handbook of Computer Networks (Hossein
`Bidgoli, ed.), John Wiley & Sons, Inc.
`
`Freedman, I. (2006), “Examination on Challenge: A Proposal for Improving the Patent System”,
`Disclosure, Jan 2006 retrieved from http://www.napp.org
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`Freedman, I. (2005), “Erythropoetin Modeling & Simulation,” retrieved from
`http://www.freedmanpatent.com
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`Freedman, I. (2004), “Working with a Patent Agent,” in PatentCafé Magazine, May 11, 2004
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`Freedman, I. (2004), “Video,” in Encyclopedia of Human-Computer Interaction (William Sims
`Bainbridge, ed.), Berkshire Publishing Group LLC
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`Freedman, I. (2003), "Video Compression," in The Internet Encyclopedia (Hossein Bidgoli, ed.),
`John Wiley & Sons, Inc.
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`Freedman, I. (2002), "Comparison of algorithms for efficient approximation of heterogeneous
`multidimensional scientific data," Astronomical Data Analysis II. (Starck, J-L; Murtagh, F D,
`ed.) in Proc. SPIE, Volume 4847, pp. 313-321
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`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`Freedman, I. (1999), "Proposal for Preliminary Evaluation of an Approximate Data Compression
`Algorithm for the FITS Standard," BAAS, 194
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`Freedman, I. and Farrelle, P. M. (1996), "Systems Aspects of COBE Science Data
`Compression," ASP Conf. Ser. 101: Astronomical Data Analysis Software and Systems V
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`Sodroski T. et al. (1995), "The Ratio of H2 Column Density to 12CO Intensity in the Vicinity of
`the Galactic Center," Ap. J. 450
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`Freedman, I., Boggess, E. & Seiler, E. (1992), "COBE Science Data Compression," BAAS, 24
`
`Freedman, I., Skard, J. A.J. & Kelsall, T. (1992), "COBE/DIRBE Sky Map Trending," in ASP
`Conf. Ser. 25: Astronomical Data Analysis Software and Systems I
`
`Freedman, I., Raugh, A. C. & Cheng, E. S. (1992), "COBE Astronomical Databases," in ASP
`Conf. Ser. 25: Astronomical Data Analysis Software and Systems I
`
`Freedman, I. et al. (1991), "COBE ground segment gyro calibration," in NASA Flight
`Mechanics/Estimation Theory Symposium
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`Kumar, V.K. et al. (1991), "COBE ground segment attitude determination," in NASA Flight
`Mechanics/Estimation Theory Symposium
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`Wright, E.L. et al. (1991), "COBE attitude refinement," in AIP Conf. Proc. 222: After the first
`three minutes
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`Wright, E. L. et al. (1989), "The COBE Attitude Determination System," BAAS 21
`
`Jackson M. J. et al. (1986), “Efficiency of tesseral arithmetic for 2.5D image manipulation on
`serial computers and transputer arrays,” in S.B.M. Bell and B.M. Diaz (eds.) Spatial Data
`Processing using Tesseral Methods, pp. 353-364.
`
`Dogiel V. et al. (1983), "Can Cosmic Rays be Accelerated in Collapsing Molecular Clouds?"
`Proc. 18th International Cosmic Ray Conference, 2
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`Giler, M. et al. (1980), "A limit to the velocity of convection of cosmic rays out of the Galaxy,"
`Proc. 16th International Cosmic Ray Conference, 2
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`Freedman, I. et al. (1980), "Derivation of the age distributions of cosmic rays in a Galaxy with a
`convective halo," AAP, 82
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`PROFESSIONAL AWARDS
`GlaxoSmithKline R&D Recognition Award (2012, 2013, 2016)
`NASA Group Achievement Award (1990, 1992)
`Hughes STX Achievement Award (1990)
`Funaro Award (2015, 2018)
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`Immanuel Freedman, Ph. D., SMIEEE, MInstP, CPhys
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`PROFESSIONAL AFFILIATIONS
`Institute of Electrical and Electronic Engineers (Senior Member; Chair, Communications &
`Information Theory Section, Philadelphia Chapter; 2019 Vice-Chair, P2673 and current member,
`P2795 Standards Working Group)
`Institute of Physics (Chartered Physicist)
`American Association of Pharmaceutical Scientists (2019/2020 Chair, Pharmaco-Imaging
`Community; 2017 Member, Predictive Modeling Task Force)
`International Society of Pharmacometrics (Standards and Best Practices Committee; Member–
`Model Evaluation Group, Data Standards Group)
`Regulatory Affairs Professionals Society
`Drug Industry Information Association, Adaptive Designs Scientific Working Group (Member)
`International Association for Assyriology
`National Coalition of Independent Scholars
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`January 15, 2020 TLR
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`Mitek Exhibit 1004, Page 012
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