PATENT
`
`20-‘2833P/fl/ fl
`
`
`
`WU
`
`NITED STATES PATENT AND TRADEMARK OFFICE
`
`Applicants :
`
`Serial No.
`
`Filed
`For
`
`:
`
`:
`:
`
`I. Saji et al.
`
`07/726,172
`
`:35 figj/
`
`£9*0
`Examiner: R. Bondfi,
`July 5, 1991
`IMIDE DERIVATIVES, AND THEIR PRODUCTION AND USE E3
`
`'
`
`Group:
`
`1202
`
`PHIE IflEEN
`
`March 1, 1993
`
`Commissioner of Patents
`and Trademarks
`
`.Washington, D. C.
`
`2023].
`
`Sir:
`
`In response to the Office Action dated November 27, 1992, the
`
`following amendments and remarks are respectfully submitted in f.
`
`connection with the above application.
`In The Claims:
`
`'
`
`1/"
`
`/ / /
`claims
`1-10
`and
`
`substitute therefor
`
`the
`
`Please
`
`cancel
`
`
` following newr cla ims .
`——/II/rI_:"-An imide compound of the fa ula:
`
`— -
`Z D N'
`
`- r
`G A
`
`LJ
`
`wherein Z is a group of the formul
`
`
`
`
`040 TD 03/léf93 O??25172
`040 TD 03516f93 07?26172
`‘
`040 TB 03516f93 G?7261?2
`
`
`102
`1 104
`
`BSaOO BK
`74.00 CR
`230.00 CE
`
`
`
`
`04% TD 03/16/93 07 tool ,
`
`$40 TD O3f15/93 0??261?2
`CéO TD 03fI6/?3 0"?'
`
`Page 1 of 11
`SLAYBACK EXHIBIT 1027
`
`Page 1 of 11
`
`SLAYBACK EXHIBIT 1027
`
`
`
`20-‘2833P/fl/ fl
`
`
`
`WU
`
`NITED STATES PATENT AND TRADEMARK OFFICE
`
`Applicants :
`
`Serial No.
`
`Filed
`For
`
`:
`
`:
`:
`
`I. Saji et al.
`
`07/726,172
`
`:35 figj/
`
`£9*0
`Examiner: R. Bondfi,
`July 5, 1991
`IMIDE DERIVATIVES, AND THEIR PRODUCTION AND USE E3
`
`'
`
`Group:
`
`1202
`
`PHIE IflEEN
`
`March 1, 1993
`
`Commissioner of Patents
`and Trademarks
`
`.Washington, D. C.
`
`2023].
`
`Sir:
`
`In response to the Office Action dated November 27, 1992, the
`
`following amendments and remarks are respectfully submitted in f.
`
`connection with the above application.
`In The Claims:
`
`'
`
`1/"
`
`/ / /
`claims
`1-10
`and
`
`substitute therefor
`
`the
`
`Please
`
`cancel
`
`
` following newr cla ims .
`——/II/rI_:"-An imide compound of the fa ula:
`
`— -
`Z D N'
`
`- r
`G A
`
`LJ
`
`wherein Z is a group of the formul
`
`
`
`
`040 TD 03/léf93 O??25172
`040 TD 03516f93 07?26172
`‘
`040 TB 03516f93 G?7261?2
`
`
`102
`1 104
`
`BSaOO BK
`74.00 CR
`230.00 CE
`
`
`
`
`04% TD 03/16/93 07 tool ,
`
`$40 TD O3f15/93 0??261?2
`CéO TD 03fI6/?3 0"?'
`
`Page 1 of 11
`SLAYBACK EXHIBIT 1027
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`Page 1 of 11
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`SLAYBACK EXHIBIT 1027
`
`
`
`Serial No. 07/726,172
`
`in which B is a carbonyl group 0
`
`a sulfonyl group, R '
`
`, R 2
`
`,
`
`R 3 and R ‘ are each a hydrogen
`
`tom or an alkyl group having 1—
`
`4 carbon atoms with a proviso ' at R ' and R 2 or R ' and R 3
`
`
`
`are combined together to make
`
`non—aromatic hydrocarbon ring
`
`having at most 7 carbon ato s and being un-substituted or
`
`{
`
`substituted with at least on
`
`alkyl group having 1,4 carbon
`
`{
`
`atoms, and n is an integer of
`
`or 1:
`
`afiii,
`
`D is a group of the form la:
`
` in which A is a non—aromatjc hydrocarbon ring having at most 7
`
`~(CH2}p— ~(CH2)q-
`
`carbon atoms and being unisubstituted or substituted with at
`
`least one alkyl group hav'ng 1-4 carbon atoms, and p and q are
`
`each an interger of 0, l
`
`r 2;
`
`Ar is a monocyclic eterocyclic aromatic group having at
`
`Page 2 of 11
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`SLAYBACK EXHIBIT 1027
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`Page 2 of 11
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`SLAYBACK EXHIBIT 1027
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`
`
`
`
`most
`
`6 carbon atoms and at mos
`
`
`
`Serial No. 07/726,172
`
`4 hetero atoms chosen from
`
`nitrogen, oxygen and sulfur, or
`
`bicyclic heterocyclic aromatic
`
`group having at most 10 carbon
`
`chosen from nitrogen, oxygen an
`
`sulfur, both of the above groups
`
`
`
`
`
`toms and at most 5 hetero atoms
`
`
`5//: Ar being unsubstituted or subst'tuted with at least one of an alkyl
`
`
`group having 1-4 carbon atoms
`atoms and a halogen atom: an G is ,,N—: or an acid addition salt
`
`
`
`an alkoxy group having 1-4 carbon
`
`thereof.
`
`
`
`rV-lzf' The imide compound accordi g to claimIlaj wherein Ar is
`
`the bicyclic heterocyclic aro
`
`
`ic group, of which one ring is a
`
`benzene un-substituted or sub;/it ted with at least one of an alkyl
`group having 1-4 carbon atoms,
`alkoxy group having 1-4 carbon
`
`acid addition salt thereof.
`atoms and a halogen atom; or
`f
`gig% The imide compound according to claim All"
`
`said non—aromatic hydrocarbon ring in Z is further bridged with an
`
`, wherein
`
`alkylene group having 1-3 carbon atoms and being un—substituted or
`
`substituted with at least one alkyl group having 1—4 carbon atoms,
`
`or an 0 gen atom: or an acid addition salt thereof.
`
`.2:
`
`‘flér#3
`
`The imide compound according to claim,£r1esefier‘wherein
`
`said non—aromatic hydrocarbon ring in D is further bridged with an
`
`alkylene group having 1-3 carbon atoms and being unsubstituted or
`
`substituted with at least one alkyl group having 1-4 carbon atoms,
`
`;'
`
`or an 0
`,2":
`
`95fjfl
`
`gen atom: or an acid addition salt thereof.
`x K
`
`The imide compound according to claim,ldfbrfii21’wherein
`
`.
`
`said non-aromatic hydrocarbon rings in z and D are further bridged
`
`3
`
`[
`
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`SLAYBACK EXHIBIT 1027
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`Page 3 of 11
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`SLAYBACK EXHIBIT 1027
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`
`
`Serial NO. 07/726,172
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`; n
`
`ith an alkylene group having 1-3 carbon atoms and being un-
`
`substituted or substituted with at least one alkyl group having 1-4
`
`carbongatoms, or an oxygen atom: or an acid addition salt thereof.
`._
`I'
`_
`.
`._,267’ The imide compound according to c1aim.i{f wherein Z is
`
`one of the following formulas:
`
`“‘— (2—1)
`
`45‘0/1
`
`L
`
`E
`
`NH
`
`I
`
`wherein L is —CH2—CH2— or —CH=CH-, E is an alkylene group having
`not more
`than 3
`carbon atoms
`and being un-substituted or
`
`M substituted with an alkyl group having not more than 4 carbon atoms
`
`or an oxygen atom, R5 is a hydrogen atom or an alkyl group having
`
`—
`
`not more than 4 carbon atoms and B is a carbonyl group or a
`
`sulfonyl group;
`
`(3—2)
`
`mm
`
`wherein L, E, R5 and B are each as defined above;
`
`Page 4 of 11
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`SLAYBACK EXHIBIT 1027'
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`Page 4 of 11
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`SLAYBACK EXHIBIT 1027
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`
`
`(2—3)
`
`Serial No. 07/726,172
`
`
`
`wherein R6, R7, R3, R9, R10, R11, R12, R13, R14 and R15 are each a
`
`hydrogen atom or an alkyl group having not more than 4 carbon
`
`atoms, or two of those present at the neighboring positions each
`
`other may be combined together to make a bond and B is as defined
`
`above: and (3-4)
`
`R16
`R17
`
`0
`
`N-
`
`6
`8/
`
`R4
`
`wherein R4 is a hydrogen atom or an alkyl group having not more
`
`than 4 carbon atoms, R16 and R17 are combined together to make a
`
`2;
`
`saturated hydrocarbon ring not more than 7 carbon atoms, and B is
`
`L/
`
`as defined above; or an acid addition salt thereof.
`
`5 9
`
`.7,
`
`Page 5 of 11
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`SLAYBACK E1XH|B|T 1027'
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`Page 5 of 11
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`SLAYBACK EXHIBIT 1027
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`Serial No. 07/726,172
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`'/
`
`'-! An imide compound of the to ula:
`
`Z-D-Nr—fiE-Ar
`L_J
`
`wherein
`
`Z is a group of the formula:
`
`0
`
`
`1&1
`ijif§::;;é;:in Lis -CH2-CH2- or-CH H-, E isanalkylenegrouphaving
`
`
`
`
`not more than 3 carbon atoms:
`
`
`
`
`D is a group of the form 1a:
`
`-(CH2)p-A-(CH2)q-
`
`
`
`wherein A is a cycloalkane ring having not more than 7 carbon
`
`atoms, p and q are each an i teger of O,
`
`1 or 2:
`
`Ar is a bicyclic heter cyclic aromatic group having not more
`
`than 10 carbon atoms and no more than 5 hetero atoms chosen from
`
`
`
`nitrogen, oxygen and sulfu : and
`.
`\\
`
`G is /,N—
`or an acid addition salt t ereof.
`
`_(HHf ‘Qrif The imide compound according to claim , wherein said
`
`cycloalkane ring in D is further bridged with an alkylene group
`
`having 1-3 carbon atoms; or an acid addition salt thereof.
`
`6
`
`Page 6 of 11
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`SLAYBACK EXHIBIT 1027
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`.'.
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`,
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`Serial No. 07/726,172
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`a" 1129f The imide compound according to claim 14/or J37 wherein
`
`I"
`
`'-.._——-_.
`
`HZ is a group of the formula:
`'
`
`7W? 1
`
`‘
`
`E
`
`\N-
`
`M
`r——/
`3 wherein‘E is a methylene group or an ethylene group; or an addition
`¢IfJW
`’I
`3’
`.3&:/ The imide compound according to claimIl3’0r J81 wherein
`
`salt thereof.
`
`D is a group of the formula:
`
`wherein A is as defined above; or an acid addition salt thereof.
`
`f
`
`M
`('D» I. “n.-
`,2e7’ The imide compound according to c1aim,267‘wherein A is a
`
`cyclohexane ring: or an acid addition salt thereof.
`’7
`8’
`' 05%. The imide compound acco ding to claim if or 181' wherein
`
`'
`
`Ar
`
`is
`
`a benzisothiazolyl
`
`a
`
`'enzisoxazolyl group,
`
`benzofuryl group,
`
`a quinoly
`
`
`
`oup,
`
`an isoquinolyl group,
`
`an
`
`
`
`
`
`
`
`
`indolyl group, an indazolyl gr p, a benzimidazolyl group or a
`
`benzoxazolyl group; or an acid addition salt thereof.
`
`I 1:52 The imide compound a cording to claim &'wherein Ar is
`a henzisothiazolyl group: or
`:1 acid addition salt thereof.
`
`"f 4;}; The imide compound of the formula:
`
`Z-D-N
`
`G-Ar
`
`\_J
`
`w erein
`
`Page 7 of 11
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`SLAYBACK EXHIBIT 1027
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`Page 7 of 11
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`SLAYBACK EXHIBIT 1027
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`
`
`
`
`herein E: is a methylene gr
`
`p or an ethylene group:
`
`D is a group of the £0 ula:
`
`'-CH2-A-CH2-
`
`
`
`
`Serial No. 07/726,172
`
`Z is a group of the formul
`
`
`
`
`wherein A is a cyclcalkan
`
`
`atoms:
`
`ring having not more than 7 carbon
`
`
`
`Ar is a henzisothiaz lyl group: and G is
`
`
`N-; or an acid
`
`I?
`[fix The imide compound according to claim 24’, wherein E is a
`
`methylene group: or an acid addition salt thereof.
`
`#9,??? The imide compound according to claimjffior Jg-“f'wherein
`
`A is a 1,2-cyclohexane—diy1 group; or an acid addition salt
`
`thereof.
`
`(#326 The imide compound of the formula:
`
`‘
`
`//¢ @074
` .2
`
`3
`
`.
`
`H
`
`H
`
`“a
`
`’
`
`‘N
`
`\_/
`
`131]
`
`\s
`
`or an acid addition salt thereof.
`
`
`8
`
`Page 8 of 11
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`SLAYBACK EXHIBIT 1027
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`Page 8 of 11
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`SLAYBACK EXHIBIT 1027
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`
`
`Serial NO. 07/726, 172
`
`Emerita
`
`Claims 1-4 and 7-10 have been rejected under 35 U.S.c. 112,
`
`first and second. paragraphs.
`
`Although the applicants do not
`
`concede the propriety of this rejection, all of the claims in the
`
`application have been cancelled and replaced with.new claims 11-27.
`
`It is believed that these new claims have been drafted in a manner
`
`to obviate each and every one of the Examiner's objections.
`
`In
`
`particular,
`
`the specific terms objected to by
`
`the Examiner have
`
`been redrafted in the new claims.
`
`Accordingly, reconsideration and withdrawal of the rejections
`
`and early allowance of all the claims are earnestly solicited.
`
`Please charge any fees or credit any overpayment pursuant to
`
`37 CFR 1.16 or 1.17 to Deposit Account No. 02-2448.
`
`Respectfully submitted,
`
`BIRCH, STEWART, KOLASCH E BIRCH
`
`(QM.$17499
`
`
`nard R. Svensson
`
`Reg. No. 30,330
`301 North Washington Street
`P.O. Box 747
`Falls Church, VA 22046-0747
`
`LES/PW
`(703) 241-1300
`
`Page 9 of 11
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`SLAYBACK EXHIBIT 1027
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`Page 9 of 11
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`SLAYBACK EXHIBIT 1027
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`
`
`
`
`O
`
`‘ i
`
`PATENT
`
`IN THE U.S. PATENT AND TRADEMARK OFFICE
`
`Applicants:
`Serial No.:
`Filed:
`For:
`
`.
`I. Saji et a1.
`§‘
`Group: 1202
`07/726,172
`i:
`Examiner: R. Bond
`July 5, 1991
`IMIDE DERIVATIVES, AND THEIR PRODUCTION AND USE;
`n?
`
`Date:M5,.
`
`Docket NO.:
`
`20-2833P
`
`LABEE_EHIIEX_IBAH§MIEEAL_EQBE
`
`Honorable Commissioner of Patents
`and Trademarks
`
`Washington, D.C.
`
`20231
`
`Sir:
`
`Transmitted herewith is an amendment
`
`in the above-identified
`
`application.
`
`The enclosed document is being transmitted via the Certificate
`of Mailing provisions of 37 C.F.R. 1.8.
`
`The fee has been calculated as shown below:
`
`CLAIMS
`REMAINING
`AFTER
`AMENDMENT
`
`HIGHEST NO.
`PREVIOUSLY
`PAID FOR
`
`TOTAL $392.00
`
`X
`
`FIRST PRESENTATION OF
`
`UTIPLE CLAIM
`
`Page 10 of 11
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`SLAYBACK EXHIBIT 1027
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`Page 10 of 11
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`SLAYBACK EXHIBIT 1027
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`
`
`for extension for
`$
`37 CFR 1.17 and 1.136(a).
`
`month(s) pursuant to
`
`No fee is required.
`
`A check in the amount of $ 392.00
`
`is enclosed.
`
`Please charge Deposit Account No. 02-2448 in the amount of
`$—. A triplicate copy of this sheet is
`attached.
`
`X
`
`If necessary, the Commissioner is hereby authorized to charge
`payment
`of
`the
`following
`fees
`associated with
`this
`communication or credit any overpayment to Deposit Account No.
`02-2448.
`
`L Any additional filing fees required under 37 CFR
`1.16.
`
`1';
`
`Any patent application processing fees under 37 CFR
`1.17.
`
`Respectfully submitted,
`
`BIRCH, STEWART, KOLASCH 8: BIRCH
`
`By
`
`
`#22]sz
`,
`
`r R. Svensson
`
`Re . No. 30,330
`
`'
`
`301 North Washington Street
`P. O. Box 747
`
`Falls Church, VA
`(703) 241-1300
`
`22040-0747
`
`LRS/pw
`
`(Rev. 10/02/92)
`
`Page11of11
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`Page 11 of 11
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`SLAYBACK EXHIBIT 1027
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