(12) United States Patent
`US 9,861,286 B1
`Islarn
`(45) Date of Patent:
`*Jan. 9, 2018
`
`(10) Patent No.:
`
`US009861286B1
`
`SHORT-WAVE INFRARED
`SUPER-CONTINUUM LASERS FOR EARLY
`DETECTION OF DENTAL CARIES
`
`(56)
`
`References Cited
`U.S. PATENT DOCUMENTS
`
`(54)
`
`(71)
`
`(72)
`
`(73)
`
`Applicant: OMNI MEDSCI, INC., Ann Arbor, MI
`(US)
`
`Inventor: Mohammed N. Islam, Ann Arbor, MI
`(US)
`
`Assignee: Omni Medsci, Inc., Ann Arbor, MI
`(US)
`
`(*)
`
`Notice:
`
`Subject to any disclaimer, the term of this
`patent is extended or adjusted under 35
`U.S.C. 154(b) by 0 days.
`
`This patent is subject to a terminal dis-
`claimer.
`
`(21)
`
`Appl. No.: 15/686,198
`
`(22)
`
`Filed:
`
`Aug. 25, 2017
`
`4,063,106 A
`4,158,750 A
`
`12/1977 Ashkin et a1.
`6/1979 Sakoe et a1.
`(Continued)
`
`FOREIGN PATENT DOCUMENTS
`
`DE
`EP
`
`102010012987 A1
`1148666
`
`10/2010
`10/2001
`
`(Continued)
`
`OTHER PUBLICATIONS
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`Istepanian, Robert H., “The Comparative Performance of Mobile
`Telemedical Systems based on the IS-54 and GSM Cellular Tele-
`phone Standards”; Journal of Telemedicine and Telecare 1999; pp.
`97-104.
`
`(Continued)
`
`Primary Examiner 7 Tarifur Chowdhury
`Assistant Examiner 7 Md M Rahman
`
`(74) Attorney, Agent, or Firm 7 Brooks Kushman PC.
`
`Related US. Application Data
`
`(57)
`
`ABSTRACT
`
`(63)
`
`Continuation of application No. 15/357,136, filed on
`Nov. 21, 2016, now Pat. No. 9,757,040, which is a
`(Continued)
`
`Int. Cl.
`
`(51)
`
`G01] 3/00
`A613 5/00
`
`US. Cl.
`
`(52)
`
`(2006.01)
`(2006.01)
`(Continued)
`
`CPC .......... A613 5/0088 (2013.01); A613 5/0013
`(2013.01); A613 5/0022 (2013.01);
`(Continued)
`Field of Classification Search
`CPC ...... G01] 3/02; G01] 3/28; G01] 3/42; G01N
`21/31; G01N 21/552
`
`(58)
`
`A wearable device for use with a smart phone or tablet
`includes LEDs for measuring physiological parameters by
`modulating the LEDs and generating a near-infrared multi-
`wavelength optical beam. At least one LED emits at a first
`wavelength having a first penetration depth and at least
`another LED emits at a second wavelength having a second
`penetration depth into tissue. The device includes lenses that
`deliver the optical beam to the tissue, which reflects the first
`and second wavelengths. A receiver is configured to capture
`light while the LEDs are 011 and while at least one of the
`LEDs is on and to difference corresponding signals to
`improve a signal-to-noise ratio of the optical beam reflected
`from the tissue. The signal-to-noise ratio is further increased
`by increasing light intensity of at least one of the LEDs. The
`device generates an output signal representing a non-inva-
`sive measurement on blood within the tissue.
`
`(Continued)
`
`20 Claims, 18 Drawing Sheets
`
`
`
`CHOPPER
`..
`
`/1273
`
`
`
`4;
`
`U
`
`INPUT SUT
`
`
`OUTPUT SLET
`AONOCHROMATOR
`LOCK-IN
`1‘sz DETECTOR é
`
`AMPLFFTER
`FREE-AMP
`
`Page 1
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`OMNI 2002 - |PR20-00209
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`Page 1
`
`OMNI 2002 - IPR20-00209
`
`

`

`US 9,861,286 B1
`
`Page 2
`
`Related US. Application Data
`.
`.
`.
`.
`cont1nuat1on of appl1cat1on No. 14/651,367, filed as
`application No. PCT/US2013/075736 on Dec. 17,
`2013, now Pat. No. 9,500,635.
`.
`.
`.
`.
`Prov1s1onal appl1cat1on No. 61/747,477, filed on Dec.
`31, 2012.
`
`(60)
`
`4,958,910 A
`4,989,253 A
`5,078,140 A
`5,084,880 A
`a
`a
`2118:3293) :
`5,142,930 A
`5,180,378 A
`5,191,628 A
`5,218,655 A
`,
`,
`253128331 2‘
`5,267,152 A
`5,267,256 A
`5,267,323 A
`5,300,097 A
`gflgggi‘g :
`a
`a
`5,313,306 A
`5,323,404 A
`5,345,538 A
`5,400,165 A
`5,408,409 A
`5,458,122 A
`5,544,654 A
`5,572,999 A
`5,617,871 A
`2,23%ng: 2
`a
`a
`5,695,493 A
`5,696,778 A
`5,704,351 A
`5,718,234 A
`282382 2
`5:792:204 A
`5,812,978 A
`5,855,550 A
`5,862,803 A
`25mg 2
`5:944:659 A
`5,950,629 A
`5,957,854 A
`5,970,457 A
`8558,1353? 2
`6:115:673 A
`6,185,535 B1
`6,200,309 B1
`222212301 3}
`,
`,
`6,246,896 B1
`6,273,858 B1
`6,278,975 B1
`gaggéag; 31
`a
`a
`6,289,238 B1
`6,301,271 B1
`6,301,273 B1
`2,33%,323 3i
`a
`a
`6,340,806 B1
`6,350,261 B1
`6,364,834 B1
`6,374,006 B1
`6,381,391 B1
`6,402,691 B1
`6,407,853 B1
`6,436,107 B1
`
`6’441’747 B1
`6,442,430 B1
`6 443 890 B1
`’
`’
`6,450,172 B1
`6,453,201 Bl
`6,454,705 B1
`6,458,120 B1
`6,462,500 B1
`6,463,361 B1
`
`'
`
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`u er
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`t
`1.
`1/1993 Km: :1 :1.
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`ar e e a.
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`11/1993 Yang et a1.
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`2888} $113“? 61131
`1n e a .
`6/2001 Dumoulin
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`$3881 Is{nllm
`1 coyne
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`.
`”002 K113” et 31:
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`'
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`
`(51)
`
`(200601)
`(200601)
`(2006.01)
`(2006.01)
`(2006.01)
`(201401)
`(201401)
`(2006.01)
`(2006.01)
`(38828?
`(
`'
`)
`(200601)
`(2006.01)
`(2006.01)
`(38828?
`(
`‘
`)
`(200601)
`
`1‘“- C"
`G01N 33/49
`G01N 33/44
`G01N33/15
`G01N 33/02
`G01N 21/88
`G01N 21/3563
`G01N 21/359
`G01] 3/453
`A613 5/145
`288133521355
`G01N 21/39
`G01M3/38
`G01] 3/28
`33% :22
`G01J3/14
`(52) US. Cl.
`CPC .......... A613 5/0075 (2013.01), A613 5/0086
`(2013.01); A613 5/1455 (2013.01); A613
`5/14532 (2013.01); A613 5/14546 (2013.01);
`A613 5/4547 (2013.01); G01] 3/108
`(201301), G0113/28 (2013.01), G0113/2823
`(201301), G0113/453 (2013.01), G01N
`21/359 (2013.01); G01N 21/3563 (2013.01);
`G01N21/39 (2013.01), G01N21/88
`(2013.01); G01N 33/02 (2013.01); G01N
`33/15 (2013.01), G01N33/442 (2013.01),
`G01N 33/49 (2013.01), A613 2562/0233
`(2013.01), A613 2562/0238 (2013.01), A613
`2562/146 (2013.01); A613 2576/02 (2013.01);
`G01] 3/14 (2013.01); G01] 3/1838 (2013.01);
`G011 2003/104 (2013.01), G01] 2003/2826
`.
`.
`(2013.01), G01M 3/38 (2013.01), G01N
`2021/399 (2013.01); G01N 2201/061
`(2013.01); G01N 2201/062 (2013.01); G01N
`2201/08 (2013.01); G01N 2201/12 (2013.01);
`_
`_
`H015 3/302 (2013.01)
`_
`(58) Fleld 0f ClaSSIficatlon Search
`USPC .......................................................... 356/300
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`.
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`
`OMNI 2002 - |PR20-00209
`
`Page 2
`
`OMNI 2002 - IPR20-00209
`
`

`

`US 9,861,286 B1
`
`Page 3
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`

`

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