US009651533B2
`
`(12) United States Patent
`US 9,651,533 B2
`Islarn
`(45) Date of Patent:
`*May 16, 2017
`
`(10) Patent No.:
`
`(54)
`
`(71)
`
`(72)
`
`SHORT-WAVE INFRARED
`SUPER-CONTINUUM LASERS FOR
`DETECTING COUNTERFEIT OR ILLICIT
`DRUGS AND PHARMACEUTICAL PROCESS
`CONTROL
`
`Applicant: OMNI MEDSCI, INC., Ann Arbor, MI
`(US)
`
`Inventor:
`
`Mohammed N. Islam, Ann Arbor, MI
`(US)
`
`(58) Field of Classification Search
`CPC ....... G01N 33/15; G01N 21/359; G01N 33/49
`(Continued)
`
`(56)
`
`References Cited
`U. S. PATENT DOCUMENTS
`
`4,063,106 A
`4,158,750 A
`
`12/1977 Ashkin et a1.
`6/1979 Sakoe et a1.
`(Continued)
`
`FOREIGN PATENT DOCUMENTS
`
`(73)
`
`Assignee:
`
`Omni Medsci, Inc., Ann Arbor, MI
`(US)
`
`CN
`DE
`
`101849821 B
`102010012987 A1
`
`7/2013
`10/2010
`
`(*)
`
`Notice:
`
`Subject to any disclaimer, the term of this
`patent is extended or adjusted under 35
`U.S.C. 154(b) by 0 days.
`
`This patent is subject to a terminal dis-
`claimer.
`
`(21)
`
`Appl. No.: 14/875,709
`
`(22)
`
`Filed:
`
`Oct. 6, 2015
`
`(65)
`
`Prior Publication Data
`
`US 2016/0047787 A1
`
`Feb. 18, 2016
`
`Related US. Application Data
`
`(63)
`
`Continuation of application No. 14/108,986, filed on
`Dec. 17, 2013, now Pat. No. 9,164,032.
`(Continued)
`
`Int. Cl.
`
`(51)
`
`G01] 5/20
`G01N 33/15
`
`US. Cl.
`
`(52)
`
`(2006.01)
`(2006.01)
`(Continued)
`
`(Continued)
`
`OTHER PUBLICATIONS
`
`Istepanian, Robert H., “The Comparative Performance of Mobile
`Telemedical Systems based on the IS-54 and GSM Cellular Tele-
`phone Standards”; Journal of Telemedicine and Telecare 1999; pp.
`97-104.
`
`(Continued)
`
`Primary Examiner 7 David Porta
`Assistant Examiner 7 Abra Fein
`
`(74) Attorney, Agent, or Firm 7 Brooks Kushman RC.
`
`(57)
`
`ABSTRACT
`
`A measurement system includes a wearable measurement
`device for measuring one or more physiological parameters,
`including a light source comprising a plurality of light
`emitting diodes (LEDs) configured to generate an output
`optical beam with a near-infrared wavelength between 700
`nanometers and 2500 nanometers. The light source is con-
`figured to increase signal-to-noise ratio by increasing a light
`intensity and pulse rate of the LEDs. The system includes a
`plurality of lenses configured to receive the output optical
`beam and to deliver an analysis output beam to a sample.
`The wearable measurement device includes a receiver con-
`
`CPC ........... G01N 33/15 (2013.01); A6IB 5/0013
`(2013.01); A6IB 5/0022 (2013.01);
`(Continued)
`
`figured to process the analysis output beam reflected or
`transmitted from the sample and to generate an output signal
`(Continued)
`
`1 800
`/
`
`1802
`1804
`CaF
`/
`1801
`\
`
`
`BS
`
`$08
`1806
`
`
`/
`CHOPPER
`$03
`POL
`
`
`7 SAMPLE DETECTOR +
`K1805
`
`SCSOURCE + MONOCHROMATOR <
`
`
`SAMPLE
`:0> PRE—AMP (MCT)
`
`
`
`
`1 807
`
`REFERENCE DETECTOR
`+ PRE—AMP (MOT)
`:1 REFERENCE
`1809
`‘— LOCK-IN AMP #1
`
`2
`
`
`
`
`
`COMPUTER
`
`
`
`/1811
`
`<— LOCK-1N AMP #2
`
`
`
`
`
`:0>
`
`/
`
`
`
`
`
`Page 1
`
`1810
`
`OMNI 2104
`
`IPR 2020-00175
`
`Page 1
`
`OMNI 2104
`IPR 2020-00175
`
`

`

`US 9,651,533 B2
`
`Page 2
`
`that may be transmitted to a remote device configured to
`process the received output status to generate processed data
`and to store the processed data.
`
`18 Claims, 26 Drawing Sheets
`
`Related US. Application Data
`
`(60) Provisional application No. 61/747,487, filed on Dec.
`31, 2012.
`
`(51)
`
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2014.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`(2006.01)
`
`Int. Cl.
`A613 5/1455
`A613 5/00
`G011 3/10
`G011 3/28
`G011 3/453
`G01N 21/359
`A613 5/145
`G01N 33/49
`HOIS 3/30
`G011 3/14
`G011 3/18
`(52) us. Cl.
`CPC .......... A613 5/0075 (2013.01); A613 5/0086
`(2013.01); A613 5/0088 (2013.01); A613
`5/1455 (2013.01); A613 5/14532 (2013.01);
`A613 5/14546 (2013.01); A613 5/4547
`(2013.01); G011 3/108 (2013.01); G011 3/28
`(2013.01); G0113/453 (2013.01); G01N
`21/359 (2013.01); G01N 33/49 (2013.01);
`A613 2562/0233 (2013.01); A613 2562/0238
`(2013.01); A613 2562/146 (2013.01); A613
`2576/02 (2013.01); G0113/14 (2013.01);
`G011 3/1838 (2013.01); G011 2003/104
`(2013.01); G011 2003/2826 (2013.01); G01N
`2201/061 (2013.01); G01N 2201/062
`(2013.01); G01N 2201/12 (2013.01); HOIS
`3/302 (2013.01)
`
`(58) Field of Classification Search
`USPC ....................................................... 250/338.4
`
`See application file for complete search history.
`
`(56)
`
`References Cited
`
`US. PATENT DOCUMENTS
`
`4,221,997
`4,275,266
`4,374,618
`4,403,605
`4,462,080
`4,516,207
`4,523,884
`4,605,080
`4,641,292
`4,704,696
`4,728,974
`4,762,455
`4,776,016
`4,958,910
`4,989,253
`5,078,140
`5,084,880
`5,086,401
`5,134,620
`5,142,930
`5,180,378
`
`>>>>>>>>>>>>>>>>>>>>>
`
`9/1980
`6/1981
`2/1983
`9/1983
`7/1984
`5/1985
`6/1985
`8/1986
`2/1987
`11/1987
`3/1988
`8/1988
`10/1988
`9/1990
`1/1991
`1/1992
`1/1992
`2/1992
`7/1992
`9/1992
`1/1993
`
`Flemming
`Lasar
`Howard
`Tanikawa
`Johnstone et a1.
`Moriyama et a1.
`Clement et a1.
`Lemelson
`Tunnell et a1.
`Reimer et a1.
`Nio et a1.
`Coughlan et a1.
`Hansen
`Taylor et a1.
`Liang et a1.
`Kwoh
`Esterowitz et a1.
`Glassman et a1.
`Huber
`Allen et a1.
`Kung et a1.
`
`5,191,628
`5,218,655
`5,230,023
`5,246,004
`5,267,152
`5,267,256
`5,267,323
`5,300,097
`5,303,148
`5,305,427
`5,313,306
`5,323,404
`5,345,538
`5,400,165
`5,408,409
`5,458,122
`5,544,654
`5,572,999
`5,617,871
`5,631,758
`5,687,734
`5,695,493
`5,696,778
`5,704,351
`5,718,234
`5,747,806
`5,748,103
`5,792,204
`5,812,978
`5,855,550
`5,862,803
`5,867,305
`5,912,749
`5,944,659
`5,950,629
`5,957,854
`5,970,457
`6,014,249
`6,043,927
`6,115,673
`6,181,414
`6,185,535
`6,200,309
`6,212,310
`6,224,542
`6,246,707
`6,246,896
`6,273,858
`6,278,975
`6,281,471
`6,285,897
`6,289,238
`6,301,271
`6,301,273
`6,333,803
`6,337,462
`6,340,806
`6,350,261
`6,364,834
`6,374,006
`6,381,391
`6,402,691
`6,407,853
`6,436,107
`6,441,747
`6,442,430
`6,443,890
`6,450,172
`6,453,201
`6,454,705
`6,458,120
`6,462,500
`6,463,361
`6,480,656
`6,512,936
`6,543,012
`6,549,702
`6,567,431
`6,587,702
`
`>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
`
`B1
`
`3/1993
`6/1993
`7/1993
`9/1993
`11/1993
`11/1993
`11/1993
`4/1994
`4/1994
`4/1994
`5/1994
`6/1994
`9/1994
`3/1995
`4/1995
`10/1995
`8/1996
`11/1996
`4/1997
`5/1997
`11/1997
`12/1997
`12/1997
`1/1998
`2/1998
`5/1998
`5/1998
`8/1998
`9/1998
`1/1999
`1/1999
`2/1999
`6/1999
`8/1999
`9/1999
`9/1999
`10/1999
`1/2000
`3/2000
`9/2000
`1/2001
`2/2001
`3/2001
`4/2001
`5/2001
`6/2001
`6/2001
`8/2001
`8/2001
`8/2001
`9/2001
`9/2001
`10/2001
`10/2001
`12/2001
`1/2002
`1/2002
`2/2002
`4/2002
`4/2002
`4/2002
`6/2002
`6/2002
`8/2002
`8/2002
`8/2002
`9/2002
`9/2002
`9/2002
`9/2002
`10/2002
`10/2002
`10/2002
`11/2002
`1/2003
`4/2003
`4/2003
`5/2003
`7/2003
`
`Byron
`Mizrahi
`Nakano
`Clarke et a1.
`Yang et a1.
`Saruwatari et a1.
`Kimura
`Lerner et a1.
`Mattson et a1.
`Nagata
`Kuban et a1.
`Grubb
`Narayannan et a1.
`Gnauck et a1.
`Glassman et a1.
`Hethuin
`Murphy et a1.
`Funda et a1.
`Burrows
`Knox et a1.
`Dempsey et a1.
`Nakajima et a1.
`MacPherson
`Mortara et a1.
`Warden et a1.
`Khalil
`Flach et a1.
`Snell
`Nolan
`Lai et a1.
`Besson et a1.
`Waarts et a1.
`Harstead et a1.
`Flach et a1.
`Taylor et a1.
`Besson et a1.
`Brant et a1.
`Fermann et a1.
`Islam
`Malin
`Raz et a1.
`Hedin et a1.
`Rice et a1.
`Waarts et a1.
`Chang et a1.
`Yin et a1.
`Dumoulin
`Fox et a1.
`Brant et a1.
`Smart
`Kilcoyne
`Besson et a1.
`Sanders et a1.
`Sanders et a1.
`Kurotori et a1.
`Smart
`Smart et a1.
`Domankevitz et a1.
`Reuss et a1.
`Islam et a1.
`Islam et a1.
`Peddjcord et a1.
`Samson et a1.
`Wang et a1.
`Khajr et a1.
`Ferek-Petric
`Schulze et a1.
`Hartlaub et a1.
`Daum et a1.
`Cosentino et a1.
`Shen et a1.
`L’Hegarat et a1.
`Wang et a1.
`Islam et a1.
`Monfre
`Viswanathan
`Islam et a1.
`Tabirian et a1.
`Ruchti
`
`Page 2
`
`OMNI 2104
`
`IPR 2020-00175
`
`Page 2
`
`OMNI 2104
`IPR 2020-00175
`
`

`

`US 9,651,533 B2
`
`Page 3
`
`(56)
`
`References Cited
`
`us. pATENT DOCUMENTS
`
`2006/0198397 A1
`2006/0223032 A1
`2006/0245461 A1
`2006/0268393 A1
`
`9/2006 K0r01eV et al.
`10/2006 Fried
`11/2006 Islam
`11/2006 Islam
`
`6,603,910 132
`6,605,080 B1
`6,611,643 B2
`6,619,835 132
`6,625,180 B2
`6,631,025 B2
`6,640,117 32
`6,659,947 B1
`6,659,999 B1
`6,738,652 B2
`6,760,148 B2
`6,773,922 132
`6,788,965 132
`6,802,811 131
`6,816,241 B2
`6,847,336 B1
`6,864,978 131
`6,885,498 132
`6,885,683 B1
`6,943,936 132
`6,990,364 B2
`7,010,336 B2
`7,027,467 B2
`7,060,061 B2
`7,105,823 B2
`7,133,710 B2
`7,167,300 B2
`7,209,657 B1
`7,233,816 B2
`7,259,906 B1
`7,263,288 B1
`7,294,105 B1
`7,299,080 BZ
`7,317,938 B2
`7.356364 B1
`7,395,158 B2
`7,433,116 Bl
`7,519,253 B2
`7519406 132
`7520574 132
`7597966 132
`7771320 32
`7,787,503 132
`7,787,924 B2
`3::383333 33
`7,848,605 B2
`7,890,158 B2
`8,000,574 B2
`8,145,286 B2
`8,157,730 B2
`8,158,493 B2
`8,180,422 B2
`8,213,007 B2
`8,430,310 B1
`8,472,108 B2
`8,509,882 B2
`8,788,002 B2
`8,948,832 B2
`9,326,712 B1
`2002/0013518 A1
`
`8/2003 Islam et 31.
`8/2003 Altshuler et 31.
`8/2003 Birk
`9/2003 Kita
`9/2003 Bufetov et a1.
`10/2003 Islam et a1.
`10/2003 MakareWicz
`12/2003 Carter et a1.
`12/2003 Anderson et 31.
`5/2004 Mattu
`7/2004 Islam
`8/2004 Jeng
`9/2004 Ruchti
`10/2004 Slepian
`11/2004 Grubisic
`1/2005 Lemelson
`3/2005 Hazen
`4/2005 151m
`4/2005 Fermann et 31,
`9/2005 Islam et a1,
`1/2006 Ruchti
`3/2006 Lorenz
`4/2006 BaeV et a1.
`6/2006 Altshuleretal.
`9/2006 Abrahamsson etal.
`11/2006 Acosta
`1/2007 Fermann etal.
`4/2007 Islam
`6/2007 Blank
`8/2007 Islam
`8/2007 Islam
`11/2007 Islam
`11/2007 Acosta
`1/2008 Lorenz
`4/2008 Bullock et al.
`7/2008 Monfre
`10/2008 Islam
`4/2009 Islam
`4/2009 Blank
`“/2009 Ruchtl
`4/2010 Monfre
`WOW Riley etal
`”010 Wadsworth
`8/2010 Acosta
`13/3818 35:33:“
`12/2010 Ridderet a1.
`2/2011 Rowe et a1.
`8/2011 Buchter
`3,2012 Ami
`4/2012 LeBoeuf etal.
`4/2012 Shah et a1.
`5/2012 Rebec
`7/2012 Wang et a1.
`4/2013 H0 et a1.
`6/2013 Islam
`8/2013 Albert et a1.
`7/2014 LeBoeuf etal.
`”015 Hong et 31.
`5,2016 Kim
`1/2002 West et a1.
`
`12/2006 P011i et a1.
`2006/0283931 A1
`1/2007 Mandelis et a1.
`2007/0021670 A1
`4/2007 Holman
`2007/0078348 A1
`4/2008 Gilley et a1.
`2008/0086318 A1
`5/2008 Kondo
`2008/0105665 A1
`“2009 Islam
`2009/0028193 A1
`4/2009 Abreu
`2009/0105605 A1
`8/2009 Islam
`2009/0204110 A1
`2009/0244288 A1* 10/2009 Fujimoto ............. H04N 5/2256
`348/164
`
`11/2009 D0r0gusker et a1.
`2009/0287067 A1
`2/2010 Fermann et a1.
`2010/0046067 A1
`6/2010 Banet et 31.
`2010/0160794 A1
`8/2010 LeBoeuf et a1.
`2010/0217102 A1
`12/2010 Pan
`2010/0322490 A1
`12/2010 Ting
`2010/0331637 A1
`2/2011 Welch et a1.
`2011/0040197 A1
`6/2011 Kim
`2011/0143364 A1
`8/2011 Welch et a1.
`2011/0208015 A1
`2011/0267688 A1* 11/2011 Kleppe .............. G02B21/0036
`359/385
`
`2014/0078510 A1*
`
`3/2014
`
`11/2011 Ridder et al.
`2011/0282167 A1
`12/2011 Kukushkin et a1.
`2011/0292376 A1
`1/2012 Wong
`2012/0013722 A1
`9/2012 Islam
`2012/0239013 A1
`12/2012 Li etal.
`2012/0310062 A1
`12/2012 Rahman etal.
`2012/0316455 A1
`10/2013 Islam
`2013/0274569 A1
`10/2013 Varadan
`2013/0281795 A1
`2013/0327966 A1* 12/2013 Fidler
`.................... G02B 26/04
`250/578.1
`Rubi0
`Guivernau ......... G01B 9/02091
`356/479
`
`2014/0081100 A1
`2014/0236021 A1
`2014/0249427 A1*
`
`3/2014 Muhsin et a1.
`8/2014 Islam
`9/2014 Liu .................... A61B1/00167
`600/477
`
`2014/0275852 A1
`2014/0275854 A1
`2015/0011851 A1
`2016/0045118 A1
`2016/0327476 A1
`
`9/2014 H0ng et al.
`9/2014 Venkatraman et al.
`1/2015 Mehta et al.
`2/2016 Kiani
`11/2016 Islam
`
`FOREIGN PATENT DOCUMENTS
`
`EP
`W0
`WO
`W0
`W0
`W0
`W0
`$8
`WO
`W0
`W0
`WO
`
`1148666
`W09715240
`W09749340
`W00150959
`0189362
`0227640
`0228123
`388383343 :3
`2009130464 A1
`2012135952 A1
`W02013012938 A1
`W02015084376 A1
`
`10/2001
`5/1997
`12/1997
`7/2001
`11/2001
`4/2002
`40002
`$88;
`10/2009
`10/2012
`1/2013
`6/2015
`
`2002/0019584 A1
`2002/0032468 A1
`
`2/2002 Sohulze et a1.
`3/2002 H111 et a1.
`
`OTHER PUBLICATIONS
`
`2002/0082612 A1
`2002/0109621 A1
`2002/0115914 A1
`2002/0128846 A1
`2002/0178003 A1
`2003/0022126 A1
`2004/0174914 A1
`2004/0240037 A1
`2005/0111500 A1
`2005/0133691 A1*
`
`6/2002 M011 et 31’
`8/2002 Khair et a1.
`8/2002 Russ
`9/2002 Miller
`1 1/2002 Gehrke et 31.
`1/2003 Buchalla
`9/2004 Fukatsu
`12/2004 Halter
`5/2005 Halter et a1.
`6/2005 D0ppke ............. H04B 10/6933
`250/214 A
`
`2006/0058683 A1
`
`3/2006 Chance
`
`Page 3
`
`Aris, Ishak Bin, “An Internet-Based Blood Pressure Monitoring
`System for Patients ; Journal of Telemedicme and Telecare 2001;
`W 51:53;
`_
`_
`_
`“Application Brief AB-070: The role of Infrared microprobe analy-
`sis in forensic drug analysis,” WWW.smithsdetecti0n.com, Jun. 27,
`2005.
`Jasco Application Note No. 200DR0188-E, “Rapid Identification of
`illegal drug using NIR (identification of MDMA tablet)”, Sep. 4,
`2008.
`Pa10u, A. J. Cruz, M. Blanco, J. Tomas, J. De Los Rios, M. Alcala,
`“Determination of drug, excipients and coating distribution in
`OMNI 2104
`
`IPR 2020-00175
`
`Page 3
`
`OMNI 2104
`IPR 2020-00175
`
`

`

`US 9,651,533 B2
`Page 4
`
`(56)
`
`References Cited
`OTHER PUBLICATIONS
`
`pharmaceutical tablets using NIR-CI,” Journal of Pharmaceutical
`Analysis, vol. 2, No. 2, pp. 90-97 (2012).
`Arnold, T., M. De Biasio, R. Leitner, “Near-Infrared Imaging
`Spectroscopy for Counterfeit Drug Detection,” Next Generation
`Spectroscopic Technologies IV, edited by M. A. Druy, R.A.
`Crocombe, Proceedings of SPIE, vol. 8032, 80320Y—1 to 7, (2011).
`Wedding, B.B., C. Wright, S. Grauf, R.D. White, “The application
`of near infrared spectroscopy for the assessment of avocado quality
`attributes,” Infrared SpectroscopyiLife and Biomedical Sciences,
`pp. 211-230 (2011).
`Michaels, C.A., T. Masiello, PM. Chu, “Fourier transform spec-
`trometry with a near infrared supercontinuum source,” Optical
`Society of America, CLEO/IQEC Conference, paper CMDD6
`(2009).
`Michaels, C.A., T. Masiello, PM. Chu, “Fourier transform spec-
`trometry with a near-infrared supercontinuum source,” Applied
`Spectroscopy, vol. 63, No. 5, pp. 538-543 (2009).
`Moros,J.,
`J. Kuligowski, G. Quintas, S. Garrigues, M. DeLa
`Guardia, “New cut-off criterion for uninformative variable elimi-
`nation in multivariate calibration of near-infrared spectra for the
`determination of heroin in illicit street drugs,” Analytica Chimica
`Acta, vol. 630, pp. 150-160 (2008).
`Moros,
`J. N. Gallpienso, R. Vilches, S. Garrigues, M. DeLa
`Guardia, “Nondestructive direct determination of heroin in seized
`illicit street drugs by diffuse reflectance near-infrared spectroscopy,”
`Analytical Chemistry, vol. 80, No. 19, pp. 7257-7265 (Oct. 1, 2008).
`Roggo, Y. P. Chalus, L. Maurer, C. Lema-Martinez, A. Edmond, N.
`Jent, “A review of near infrared spectroscopy and chemometrics in
`pharmaceutical technologies,” Journal of Pharmaceutical and Bio-
`medical Analysis, vol. 44, pp. 683-700 (2007).
`Pojic, M. J. Mastilovic, N. Majcen, “The application of near infrared
`spectroscopy in wheat quality control,” Infrared Spectroscopyi
`Life and Biomedical Sciences, pp. 167-184 (2012).
`Reich, G. “Near-infrared spectroscopy and imaging: basic prin-
`ciples and pharmaceutical applications,” Advanced Drug Delivery
`Reviews, vol. 57, pp. 1109-1143 (2005).
`Rodionova, O.Y., L.P. Houmoller, A.L. Pomerantsev, P. Geladi, J.
`Burger, V.L. Dorofeyev, A.P. Arzamastsev, “NIR spectrometry for
`counterfeit drug detection: a feasibility study,” Analytica Chimica
`Acta, vol. 549, pp. 151-158 (2005).
`Schneider, R.C., K.A. Kovar, “Analysis of ecstasy tablets: compari-
`son of reflectance and transmittance near infrared spectroscopy,”
`Forensic Science International, vol. 134, pp. 187-195 (2003).
`Olsen, B.A., M.W. Borer, F.M. Perry, R.A. Forbes, “Screening for
`counterfeit drugs using near-infrared spectroscopy,” Pharmaceutical
`Technology, pp. 62-71 (Jun. 2002).
`Scafi, S.H.F., C. Pasquini, “Identification of counterfeit drugs using
`near-infrared spectroscopy,” Analyst, vol. 126, pp. 2218-2224
`(2001).
`Sondermann, N., K.A. Kovar, “Identification of ecstasy in complex
`matrices using near-infrared spectroscopy,” Forensic Science Inter-
`national, vol. 102, pp. 133-147 (1999).
`Rambla, F.J., S. Garrigues, M. DeLa Guardia, “PLS-NIR determi-
`nation of total sugar, glucose, fructose and sucrose in aqueous
`solutions of fruit juices,” Analytica Chimica Acta, vol. 344, pp.
`41-53 (1997).
`Hori, Takashi, et al., “Flatly broadened, wideband and low noise
`supercontinuum generation in highly nonlinear hybrid fiber”, Optics
`Express, vol. 12, No. 2, Jan. 26, 2004, pp. 317-324.
`Wadsworth, W. J., et al., “Supercontinuum and four-wave mixing
`with Q-switched pulses in endlessly single-mode photonic crystal
`fibres”, Optics Express, vol. 12, No. 2, Jan. 26, 2004, pp. 299-309.
`Hilligsoe, Karen Marie, et al., “Supercontinuum generation in a
`photonic crystal
`fiber with two zero dispersion wavelengths”,
`Optics Express, vol. 12, No. 6, Mar. 22, 2004, pp. 1045-1054.
`Venugopalan, V., “Optical Society of America BIOMED Topical
`Meeting Tutorial on Tissue Optics”, Apr. 27, 2004, pp. 1-32.
`Page 4
`
`Slusher, Richart E., et al., “Large Raman gain and nonlinear phase
`shifts in high-purity As2So3 chalcogenide fibers”, J. Opt. Soc. Am.
`B, vol. 21, No. 6, Jun. 2004, pp. 1146-1155.
`Leon-Saval, S. G., et al., “Supercontinuum generation in submicron
`fibre waveguides”, Optics Express, vol. 12, No. 13, Jun. 28, 2004,
`pp. 2864-2869.
`Nicholson, J. W., et al., “High power, single mode, all-fiber source
`of femtosecond pulses at 1550 nm and its use in supercontinuum
`generation”, Optics Express, vol. 12, No. 13, Jun. 28, 2004, pp.
`3025-3034.
`Genty, G., et al., “Enhanced bandwidth of supercontinuum gener-
`ated m microstructured fibers”, Optics Express, vol. 12, No. 15, Jul.
`26, 2004, pp. 3471-3480.
`Champert, Pierre-Alain, et al., “White-light supercontinuum gen-
`eration in normally dispersive optical fiber using original multi-
`wavelength pumping system”, Optics Express, vol. 12, No. 19, Sep.
`20, 2004, pp. 4366-4371.
`Nicholson, J. W., “Supercontinuum generation in ultraviolet-irradi-
`ated fibers”, Optics Letters, vol. 29, No. 20, Oct. 15, 2004, pp.
`2363-2365.
`Hori, Takashi, et al., “Experimental and numerical analysis of
`widely broadened supercontinuum generation in highly nonlinear
`dispersion-shifted fiber with a femtosecond pulse”, J. Opt. Soc. Am.
`B, vol. 21, No. 11, Nov. 2004, pp. 1969-1980.
`Demircan, Ayhan, et al., “Supercontinuum generation by the modu-
`lation instability”, Optics Communications 244, 2005, pp. 181-185.
`Papernyi, S.B., et al., “Sixth-Order Cascaded Raman Amplifica-
`tion”, OFC/NFOEC, 2005, 3 pages.
`Tanaka, Keiji, “Optical nonlinearity in photonic glasses”, Journal of
`Materials Science: Materials in Electronics 16, 2005, pp. 633-643.
`Westbrook, Paul 8.,
`“Improved Supercontinuum Generation
`Through UV Processing of Highly Nonlinear Fibers”, Journal of
`Lightwave Technology, vol. 23, No. 1, Jan. 2005, pp. 13-18.
`Abeeluck, Akheelesh K., et al., “Continuous-wave pumping in the
`anomalous- and normal dispersion regimes of nonlinear fibers for
`supercontinuum generatfon”, Optics Letters, vol. 30, No. 1, Jan. 1,
`2005, pp. 61-63.
`Kutz,
`J. Nathan, et al., Enhanced Supercontinuum Generation
`through Dispersion-Management, Optics Express, vol. 13, No. 11,
`May 30, 2005, pp. 3989-3998.
`Lee, Ju Han, et al., “Experimental performance comparison for
`various continuous-wave supercontinuum schemes: ring cavity and
`single pass structures”, Optics Express, vol. 13, No. 13, Jun. 27,
`2005, pp. 4848-4853.
`Saliminia, A., et al., “Ultra-broad and coherent white light genera-
`tion in silica glass by focused femtosecond pulses at 1.5pm”, Optics
`Express, vol. 13, No. 15, Jul. 25, 2005, pp. 5731-5738.
`Takushima, Yuichi, High average power, depolarized super-con-
`tinuum generation using a 1.55-um ASE noise source, Optics
`Express, vol. 13, No. 15, Jul. 25, 2005, pp. 5871.-5877.
`Travers, J. C., et al., “Extended continuous-wave supercontinuum
`generation in a low-water-loss holey fiber”, Optics Letters, vol. 30,
`No. 15, Aug. 1, 2005, pp. 1938-1940.
`Kobtsev,
`Serguei M.,
`et
`al.,
`“Modelling of high-power
`supercontinuum generation in highly nonlinear, dispersion shifted
`fibers at CW pump”, Optics Express, vol. 13, No. 18, Sep. 5, 2005,
`pp. 6912-6918.
`Falk, Peter, et al., “Supercontinuum generation in a photonic crystal
`fiber with two zero-dispersion wavelengths tapered to normal
`dispersion at all wavelengths”, Optics Express, vol. 13, No. 19, Sep.
`19, 2005, pp. 7535-7540.
`Tombelaine, Vincent, et al., “Ultra wide band supercontinuum
`generation in air-silica holey fibers by SHG-induced modulation
`instabilities”, Optics Express, vol. 13, No. 19, Sep. 19, 2005, pp.
`7399-7404.
`Lee, Ju Han, et al., “Continuous-wave supercontinuum laser based
`on an erbium-doped fiber ring cavity incorporating a highly non-
`linear optical fiber”, Optics Letters, vol. 30, No. 19, Oct. 1, 2005,
`pp. 2599-2601.
`Genty, G., et al., “Supercontinuum generation in large mode-area
`microstructured fibers”, Optics Express, vol. 13, No. 21, Oct. 17,
`2005, pp. 8625-8633.
`
`OMNI 2104
`
`IPR 2020-00175
`
`Page 4
`
`OMNI 2104
`IPR 2020-00175
`
`

`

`US 9,651,533 B2
`Page 5
`
`(56)
`
`References Cited
`OTHER PUBLICATIONS
`
`Schreiber, T., et al., “Supercontinuum generation by femtosecond
`single and dual wavelength pumping in photonic crystal fibers with
`zero dispersion wavelengths”, Optics Express, vol. 13, No. 23, Nov.
`14, 2005, pp. 9556-9569.
`Travers, J. C., et al., “Extended blue supercontinuum generation in
`cascaded holey fibers”, Optics Letters, vol. 30, No. 23, Dec. 1, 2005,
`pp. 3132-3134.
`Hagen, C. L., et al., “Generation of a Continuum Extending to the
`Midinfrared by Pumping ZBLAN Fiber With an Ultrafast 1550-nm
`Source”, IEEE Photonics Technology Letters, vol. 18, No. 1, Jan. 1,
`2006, pp. 91-93.
`octave-spanning
`of
`“Generation
`al.,
`et
`Moon,
`Sucbei,
`supercontinuum with 1550-nm amplified diode-laser pulses and a
`dispersion-shifted fiber”, Optics Express, vol. 14, No. 1, Jan. 9,
`2006, pp. 270-278.
`Fedotova, 0., et al., “Supercontinuum generation in planar rib
`waveguides enabled by anomalous dispersion”, Optics Express, vol.
`14, No. 4, Feb. 20, 2006, pp. 1512-1517.
`Harrington, James A., “Infrared Fiber Optics”, OSA Handbook, vol.
`III, white paper, to be published by McGraw Hill, Undated, 13
`pages.
`Aaviksoo, J., et al., “Observation of optical precursors at pulse
`propagation in GaAs”, Physical Review A, vol. 44, No. 9, Nov. 1,
`1991, pp. R5353-R5356.
`Boppart, Stephen A., et al., “Imaging developing neural morphol-
`ogy using optical coherence tomography”, Journal of Neuroscience
`Methods 70, 1996, pp. 65-72.
`Boppart, Stephen A., et al., “Noninvasive assessment of the devel-
`oping Xenopus cardiovascular system using optical coherence
`tomography”, Prec. Natl. Acad. Sci. USA, vol. 94, Apr. 1997, pp.
`4256-4261.
`Tearney, Guillermo J., et al., “In vivo Endoscopic Optical Biopsy
`with Optical Coherence Tomography”, Science, New Series, vol.
`276, Jun. 27, 1997, pp. 2037-2039.
`de Boer, Johannes F., et al., “Imaging thermally damaged tissue by
`polarization sensitive optical coherence tomography”, Optics
`Express 212, vol. 3, No. 6, Sep. 14, 1998, pp. 212-218.
`Roggan, Andre, et al., “Optical Properties of Circulating Human
`Blood in the Wavelength Range 400-2500 NM”, Journal of Bio-
`medical Optics, vol. 4, No. 1, Jan. 1999, pp. 36-46.
`de Boer, Johannes F., et al., “Determination of the depth-resolved
`Stokes parameters of light backscattered from turbid media by use
`of polarization-sensitive optical coherence tomography”, Optics
`Letters, vol. 24, No. 5; Mar. 1, 1999, pp. 300-302.
`Rollins, Andrew M., et al., “Real-time in vivo imaging of human
`gastrointestinal ultrastructure by use of endoscopic optical coher-
`ence tomography with a novel efficient
`interferometer design”,
`Optics Letters, vol. 24, No. 19, Oct. 1, 1999, pp. 1358-1360.
`D’Amico, Anthony V., et al., “Optical Coherence Tomography As a
`Method for Identifying Benign and Malignant Microscopic Struc-
`tures in the Prostate Gland”, Basic Science, Urology 55 (5), 2000,
`pp. 783-787.
`Li, Xingde, et al., “Imaging needle for optical coherence tomogra-
`phy”, Optics Letters, vol. 25, No. 20, Oct. 15, 2000, pp. 1520-1522.
`Oughstun, Kurt E., “Influence of precursor fields on ultrashort pulse
`autocorrelation measurements and pulse width evolution”, Optics
`Express, vol. 8, No. 8, Apr. 9, 2001, pp. 481-491.
`Kowalevicz, Andrew M., et al., “Ultrahigh resolution optical coher-
`ence tomography using a superluminescent light source” Optics
`Express 349, vol. 10, No. 7, Apr. 8, 2002, pp. 349-353.
`Povazay, B., et al., “Submicrometer axial resolution optical coher-
`ence tomography”, Optics Letters, vol. 27, No. 20, Oct. 15, 2002,
`pp. 1800-1802.
`Xie, T.-Q., et al., “Detection of tumorigenesis in urinary bladder
`with optical coherence tomography: optical characterization of
`morphological changes”, Optics Express, vol. 10, No. 24, Dec. 2,
`2002, 2003, pp. 1431-1443.
`
`Seefeldt, Michael, et al., “Compact white-light source with an
`average output power of 2.4 Wand 900 nm spectral bandwidth”,
`Optics Communications 216, pp. 199-202.
`Wang, Yimin, et al., “Ultrahigh-resolution optical coherence tomog-
`raphy by broadband continuum generation from a photonic crystal
`fiber”, Optics Letters, vol. 28, No. 3, Feb. 1, 2003, pp. 182-184.
`Bizheva, K, et al., “Compact, broad-bandwidth fiberlaserforsub-2-
`pm axial resolution optical coherence tomography in the 1300-nm
`wavelength region,” Optics Letters, vol. 28, No. 9, May 1, 2003, pp.
`707-709.
`Hazen, K.H., M.A. Arnold, G.W. Small, “Measurement of glucose
`and other analytes in undiluted human serum with near-infrared
`transmission spectroscopy,” Analytica Chimica Acta, vol. 371, pp.
`255-267 (1998).
`Malin, S.F., T.L. Ruchti, T.B. Blank, S.N. Thennadil, S.L. Monfre,
`“Noninvasive prediction of glucose by near-infrared diffuse reflec-
`tance spectroscopy,” Clinical Chemistry, vol. 45, No. 9, pp. 1651-
`1658 (1999).
`Thennadil, S.N., J.L. Rennert, B.J. Wenzel, K.H. Hazen, T.L.
`Ruchti, M.B. Block, “Comparison of glucose concentration in
`interstitial
`fluid, and capillary and venous blood during rapid
`changes in blood glucose levels,” Diabetes Technology & Thera-
`peutics, vol. 3, No. 3, pp. 357-365 (2001).
`Troy, T.L., S.N. Thennadil, “Optical properties of human skin in the
`near infrared wavelength range of 1000 to 2200nm,” Journal of
`Biomedical Optics, vol. 6, No. 2, pp. 167-176, (2001).
`Blank, T.B., T.L. Ruchti, A.D. Lorenz, S.L. Monfre, M.R.
`Makarewicz, M. Mattu, K.H. Hazen, “Clinical results from a
`non-invasive blood glucose monitor,” Optical Diagnostics and
`Sensing of Biological Fluids and Glucose and Cholesterol Moni-
`toring II, A.V. Priezzhev and G.L. Cote, Editors, Proceedings of
`SPIE, vol. 4624, pp. 1019 (2002).
`Yeh, S-J, C.F. Hanna, O.S. Khalil, “Monitoring blood glucose
`changes in cutaneous tissue by temperature-modulated localized
`reflectance measurements,” Clinical Chemistry, vol. 49, No. 6, pp.
`924-934 (2003).
`Marbach, R., T. Koschinsky, E.A. Gries, H.M. Heise, “Noninvasive
`blood glucose assay by near-infrared diffuse reflectance spectros-
`copy of the human inner lip,” Applied Spectroscopy, vol. 47, No. 7,
`pp. 875-881 (1993).
`Enejder, A.M.K., T.G. Scecina, J. Oh, M. Hunter, W.C. Shih, S.
`Sasic, G.L. Horowitz, M.S. Feld, “Raman spectroscopy for nonin-
`vasive glucose measurements,” Journal of Biomedical Optics, vol.
`10, No. 3, 031114 (2005).
`Olesberg, J.T., L. Liu, V.V. Zee, M.A. Arnold, “In vivo near-infrared
`spectroscopy of rat skin tissue with varying blood glucose levels,”
`Analytic Chemistry, vol. 78, No. 1, pp. 215-223 (2006).
`Olesberg, J.T., M.A. Arnold, C. Mermelstein, J. Schmitz, J. Wagner,
`“Tunable laser diode system for noninvasive blood glucose mea-
`surements,” Applied Spectroscopy, vol. 59, No. 12, pp. 1480-1484
`(2005).
`Harman-Boehm, I. A. Gal, A.M. Raykhman, J.D. Zahn, E. Naidis,
`Y. Mayzel, “Noninvasive glucose monitoring: a novel approach,”
`Journal of Diabetes Science and Technology, vol. 3, No. 2 pp.
`253-260 (2009).
`Kim-K.D. G.S. Son, S.S. Lim, S.S. Lee, “Measurement of glucose
`level exploiting a relative optical absorption at discrete probe
`wavelengths,” Japanese Journal oprplied Physics, vol. 48, 077001
`(2009).
`Smith, J.L., “The Pursuit of Noninvasive Glucose: Hunting the
`Deceitful Turkey,” 2nd Edition, pp. 1-141 (2011).
`Pezzaniti, J.L., T.W. Jeng, L. McDowell, G.M. Costa, “Preliminary
`investigation of near-infrared spectroscopic measurements of urea,
`creatinine, glucose, protein and ketone in urine,” Clinical Biochem-
`istry, vol. 34, pp. 239-246 (2001).
`Lussi, A., R. Hibst, R. Paulus, “Diagnodent: An optical method for
`caries detection,” Journal of Dental Research, vol. 83, special issue
`C, pp. C80-C83 (2004).
`“Photoelectric
`Reese,
`E.L,
`E.E.
`Fisher, D.A. Horowitz,
`densitometry of the circulation of the human dental pulp,” The
`Journal of the Baltimore College of Dental Surgery, vol. 26, No. 1,
`pp. 6-18 (1971).
`
`Page 5
`
`OMNI 2104
`
`IPR 2020-00175
`
`Page 5
`
`OMNI 2104
`IPR 2020-00175
`
`

`

`US 9,651,533 B2
`Page 6
`
`(56)
`
`References Cited
`OTHER PUBLICATIONS
`
`I. Pretty, R. Ellwood, “Near-infrared hyperspectral
`Zakian, C.,
`imaging of teeth for dental caries detection,” Journal of Biomedical
`Optics, vol. 16, No. 6, 064047 (2009).
`Belikov, A.V., A.V. Skripnik, K.V. Shatilova, “Study of the dynam-
`ics of the absorption spectra of human tooth enamel and dentine
`under heating and ablation by submillisecond pulse radiation of an
`erbium laser with a generation wavelength of 2.79 um,” Optics and
`Spectroscopy, vol. 109, No. 2, pp. 211-216 (2010).
`Karlsson, L. “Caries detection methods based on changes in optical
`properties between healthy and carious tissue,” International Jour-
`nal of Dentistry, vol. 2010, Article ID 270729, 9 pages (2010).
`Fried, D. M. Staninec, C.L. Darling, “Near-infrared imaging of
`dental decay at 1310nm,” Journal of Laser Dentistry, vol. 18, No. 1,
`pp. 8-16 (2010).
`Burmen, M. P. Usenik, A. Fidler, F. Pernus, B. Likar, “A construc-
`tion of standardized near infrared hyper-spectral teeth databaseia
`first step in the development of reliable diagnostic tool for quanti-
`fication and early detection of caries,” Lasers in Dentistry XVII,
`edited by P. Rechmann, D. Fried, Proceedings of SPIE, vol. 7884,
`Paper 78840E (2011).
`Maia, A., L. Karlsson, W. Margulis, A. Gomes, “Evaluation of two
`imaging techniques: near-infrared transillumination and dental
`radiographs for the detection of early approximal enamel caries,”
`Dentomaxillofacial Radiology, vol. 40, pp. 429-433 (2011).
`Chung, S., D. Fried, M. Staninec, C.L. Darling, “Multispectral
`near-IR reflectance and transillumination imaging of teeth,” Bio-
`medical Optics Express, vol. 2, No. 10, pp. 2804-2814 (2011).
`Chung, S., D. Fried, M. Staninec, C.L. Darling, “Near infrared
`imaging of teeth at wavelengths between 1200 and 1600nm,”
`Proceedings of the Society of Photo Optical Instrument Engineer-
`ing, paper 7884 (2011).
`Staninec, M., S.M. Douglas, C.L. Darling, K. Chan, H. Kang, R. C.
`Lee, D. Fried, “Nondestructive clinical assessment of occlusal
`caries lesions using near-IR imaging methods,” Lasers in Surgery
`and Medicine, vol. 43, No. 10, pp. 951-959 (2011).
`Nishizawa, N.,
`“Generation and application of high-quality
`supercontinuum sources,” Optical Fiber Technology, vol. 18, pp.
`394-402 (2012).
`Sun, Y., C.F. Booker, S. Kumari, R.N. Day, M. Davidson, A.
`Periasamy, “Characterization of an orange acceptor fluorescent
`protein for sensitized spectral fluorescence resonant energy transfer
`microscopy using a white-light
`laser,” Journal of Biomedical
`Optics, vol. 14, No. 5, paper 054009 (2009).
`Borlinghaus, R., “Colours Count: how the challenge of fluorescence
`was solved in confocal microscopy,” in Modern Research and
`Educational Topics in Microscopy, A. Mendez-Vilas and J. Diaz,
`eds, pp. 890-899, Formatex (2007).
`Borlinghaus, R., “The White Confocal: Continuous Spectral Tuning
`in Excitation and Emission,” in Optical Fluorescence Microscopy,
`A. Diaspro (Ed), Chapter 2, pp. 37-54, ISBN 978-3-642-15174-3,
`Springer-Verlag, Berlin (2011).
`Borlinghaus, R.T., L. Kuschel, “White Light Laser: The Ultimate
`Source for Confocal Microscopy,” http://www.leica-microsystems.
`com/science-lab/white-light-laser (Jun. 27, 2012).
`Ziegler, U., A.G. Bittermann, M. Hoechli, “Introduction to Confocal
`Laser Scanning Microscopy (LEICA),” www.zmb.unizh.ch, May
`29, 2013.
`Pan, Yingtian, et al., “Hand-held arthroscopic optical coherence
`tomography for in vivo high-resolution imaging of articular carti-
`lage”, Journal of Biomedical Optics 8(4), Oct. 2003, pp. 648-654.
`Xie, Tuqiang, et al., “Endoscopic optical coherence tomography
`with a modified microelectromechanical systems mirror for detec-
`tion of bladder cancers”, Applied Optics, vol. 42, No. 31, Nov. 1,
`2003, pp. 6422-6426.
`Dubois, A., et al., “Three-dimensional cellular-level imaging using
`full-field optical coherence tomography”, Physics in Medicine and
`Biology, Phys. Med. Biol. 49, 2004, pp. 1227-1234.
`Page 6
`
`Park, Jesung, et al., “Analysis of birefringent image in the retinal
`nerve fiber layer by polarization sensitive optical coherence tomog-
`raphy”, Ophthalmic Technologies XIV, Proceedings of SPIE, vol.
`5314, 2004, pp. 188-194.
`Unterhuber, A., et al., “Advances in broad bandwidth light sources
`for ultrahigh resolution optical coherence tomography”, Physics in
`Medicine and Biology, Phys. Med. Biol. 49, 2004, pp. 1235-1246.
`Drexler, Wolfgang, “Ultrahigh-resolution optical coherence tomog-
`raphy”, Journal of Biomedical Optics, vol. 9, No. 1, Jan/Feb. 2004,
`pp. 47-74.
`Schmitt, Joseph, et al., “Intravascular Optical Coherence Tomog-
`raphy Opens a Window Onto Coronary Artery Disease”, Optics &
`Photonics News, Feb. 2004, pp. 20-25.
`Nassif, N.A., et al., “In vivo high-resolution video-rate spectral-
`domain optica