throbber
LMNOMPQRÿTPNNUVWX0:>E2034
`
`
`
ÿÿ  ÿÿ

`   
`'()*+,-.ÿ01ÿ23ÿ454670378ÿ6290:;<ÿ4=>;=037ÿ10?@2?0>3A
`B4?ÿ?C4ÿ;2?41?ÿ9@D;0EÿC42;?Cÿ03F>652?0>3ÿF6>5ÿ'+'GÿC??91GHHIIIAE>6>32=06@1A7>=A
`B4?ÿ?C4ÿ;2?41?ÿ641426ECÿF6>5ÿJ*KGÿC??91GHHIIIA30CA7>=HE>6>32=06@1A
`YZ[\]^_ÿ\ab
`cded
`fghZigZh^
`j03:ÿk050;26ÿk?6@E?@641
`¦+
`«+
`'6<1?2;
`\]^_limnÿfmo^gp
`X2D>62?>6<ÿ'C450E2;ÿk2F4?<ÿk@5526<ÿqX'kkrÿ+2?21C44?
`*660?23?
`stn^iZnmhÿuth_Znm
`'KJ(
`xyz{|}y~
`-¬¦¦¦
`€ce‚ƒd
`„y…~{|}y~
`fpvtvp_w
`†‡x{|}y~
`ˆ‰RyŠ‹‡x}Œy~{Q‰ˆŽdzyŒŠ‹‡x‹~‡x}|Š}Œyz
`>64AAA
`stn^iZnmhÿ‘^l’]g
`ˆc“”c“ÿ…•Œ{x
`N{zy–‡ˆ—ˆ—€€€‚L˜}Šˆ——‚—cˆ‚
`bmg^w
`„yz{|}y~ÿy™ÿ}ÿ™‡~Š‹Šy|ÿ}Œy~{Š‹‡x}ŒyzÿšyŠ‹ÿx{|}xÿ}~™Š‹Šy|ÿ}~zÿ}~Šy}˜˜‹‡Š‹Œy|ÿ˜{˜Šy™”ÿ„yz{|}y~ÿ™Š}›yxyœ™ÿŠ‹ÿ~˜{~}xÿŒŒ›˜}~ÿ›‡ÿ›y~zy~…ÿŠ{ÿ}~zÿy~‹y›yŠy~…
`ž{xŠ}……}Šzÿ1>:0@5ÿ|‹}~~x™ŽÿŠ‹˜›‡ÿy~‹y›yŠy~…ÿŠ‹ÿy{~y|ÿ–xŸ™ÿ˜ y˜zÿ–{˜ÿŠ‹ÿy~yŠy}Šy{~ÿ}~zÿ|{~z|Šy{~ÿ{–ÿyŒx™™ÿ}~zÿ––|Šy~…ÿx{|}xÿ}~™Š‹™y}”
`J'*ÿ¡C412@6@1ÿqJ'*?r
`¢‹ÿ}Œyzÿx{|}xÿ}~™Š‹Šy|™ÿy~|xzy~…ÿxyz{|}y~ŽÿD@90=2E2034ÿ}~zÿ6>90=2E2034ÿ}˜ÿ|{ŒŒ{~x‡ÿ™zÿ–{˜ÿ}y~ÿ|{~Š˜{xÿz˜y~…ÿŒy~{˜ÿ™˜…˜‡ÿ{˜ÿy~ž}™yžÿ˜{|z˜™ÿ™|‹ÿ}™
`›y{™y™Žÿ™Œ}xxÿŸ|y™y{~™ÿ{˜ÿz~Š}xÿš{˜£”ÿ¢‹™ÿx{|}xÿ}~™Š‹Šy|™ÿ‹}žÿ~{Šÿ›~ÿxy~£zÿŠ{ÿ™˜Œÿ~œ‡Œÿxž}Šy{~™Žÿ›Šÿš‹~ÿ…yž~ÿ}™ÿ|{~™Š}~Šÿy~–™y{~™ÿ{˜ÿ˜}Šz
`y~¤|Šy{~™ÿ‹}žÿ›~ÿ{||}™y{~}xx‡ÿŒ~Šy{~zÿ}™ÿ{™™y›xÿ|}™™ÿ{–ÿ|xy~y|}xx‡ÿ}}˜~Šÿxyž˜ÿy~¤˜‡”
`X0=46¡>¥
`„yz{|}y~ÿy™ÿŠ‹ÿŒ{~{|}˜›{Ÿ‡xy|ÿ}|yzÿ}Œyzÿ˜™xŠy~…ÿ–˜{ŒÿŠ‹ÿ–{˜Œ}xÿ|{~z~™}Šy{~ÿ{–ÿJ8J,:04?C<;7;<E034ÿšyŠ‹ÿ¦8§,:054?C<;230;034”ÿ¨Šÿ‹}™ÿ}ÿ˜{xÿ}™ÿ}ÿx{|}xÿ}~}™Š‹Šy|Žÿ}~
`}~Šy}˜˜‹‡Š‹Œy}ÿz˜…Žÿ}~ÿ~žy˜{~Œ~Š}xÿ|{~Š}Œy~}~ŠŽÿ}ÿŸ~{›y{Šy|ÿ}~zÿ}ÿz˜…ÿ}xx˜…~”ÿ¨Šÿy™ÿ}ÿŒ{~{|}˜›{Ÿ‡xy|ÿ}|yzÿ}ŒyzŽÿ}ÿŠ˜Šy}˜‡ÿ2503>ÿ|{Œ{~zÿ}~zÿ}ÿŒŒ›˜ÿ{–
`›~œ~™”ÿ¨Šÿz˜yž™ÿ–˜{Œÿ}ÿ7;<E03250:4”
`'C©ª*
`  
    !   
`
"
 #$%
`
`ALL 2200 FFF
`PROLLENIUM V. ALLERGAN
`IPR2019-01505, et al.
`
` &
`
`

`

`11/19/2020
`
`1 Structures
`
`1.1 2D Structure
`
`Lidocaine I C14H22N20 - PubChem
`
`
`
ÿÿ  ÿÿ

`
`Chemical Structure
`Depiction
`
`H"Hfü
`
`'()*+,)+*-.
`   
`'/'01ÿ()*+,)+*-
`DbKI_TQRÿSPLHTPHLK
`EK^_TP_`a
`'/081ÿ59:;9*7-*
`3+456-7
`caPKLQTP_dKÿDbKI_TQR
`SPLHTPHLKÿe`fKR
`g=>>ÿ=:hÿ()@,]
`()@,].i@*-jk*=7-
`(\=,-jk@>>@:A
`(69?ÿl<h*9A-:.
`m:@7=)-
`'/85*<.)=>ÿ()*+,)+*-.
`3+456-7
`(69?@:Aÿ'ÿ9;ÿ0B@-?ÿC9*-
`DDEDÿGHIJKL
`M8MM88
`DLNOPQRÿSPLHTPHLKÿEQPQ
`1UVW'X/YY'Z[,,\,A]'
`DLNOPQRÿSPLHTPHLKÿEK^_TP_`a
`  
    !   
`
"
 #$%
`
`I PubChem
`
`1.2 3D Conformer
`
`Interactive Chemical
`Structure Model
`
`OBall and Stick
`
`OSticks
`
`OWire-Frame
`
`OSpace -Filling
`
`QShow Hydrogens
`
`ElAnimate
`
`I PubChem
`
`1.3 Crystal Structures
`Showing 1 of 2 View More U
`
`CCDC Number
`
`636633
`
`Crystal Structure Data
`
`DOI:10.5517 /ccpcgkl
`
`Crystal Structure Depiction
`
`https : / /pubchem.ncbi.nlm.nih.gov/ compound /Lidocaine#section = Solubility
`
`e El
`O G
`
`,L
`
`+
`
`O r
`,
`
`L a
`
`+
`
`O r
`
`2/74
`
` &
`
`

`

`11/19/2020
`
`Associated Article
`
`DO|:10.1107/51600536807001523
`
`Lidocaine | C14H22N20 - PubChem
`
`
`
ÿÿ  ÿÿ

`
`   
`456789:889;<=8>99?@>A9;998?B@
`())*+,-./0ÿ(2.,+3/
`CDEÿGHIJKLMNEÿ=OKPQOPKHRÿ4HOHJHSE
`
`) The Cambridge Structural Database
`
`https://pubchem.ncbi.nlm.nih.gov/compound/Lidocaine#section=Solubility
`
`  
    !   
`
"
 #$%
`
`3/74
`
`& '
`
`

`

`'()*+,ÿ)./ÿ0/+.1232+4,
`
`
ÿÿ  ÿÿ

`   
`'5678*9:1+/ÿ;+,<429184,
`'56560=>?7ÿ()*+
`@ABCDEFGHIJKDLMNAOAB@PQACDKEFGHIRGELHINJSEFJKDCE
`TUVWXYZ[ÿ]^ÿ_Z`aTbZVÿcdedeÿfgX]TbZVÿhZiZjkZÿclmndledmop
`>:q7r+*
`'565'0.7r0
`sLtGsuvwxtvyz@@{@|xSvA}AvQBQA@Nv~AvBv€Nv}AvyAvvBNA€A‚Av@BvyNyxG€A‚zP}AQPv~z@PvAyzPBzPv}Pv€N
`TUVWXYZ[ÿ]^ÿƒ„Tbƒÿmdld…ÿfgX]TbZVÿhZiZjkZÿclmndledmop
`>:q7r+*
`'565†0.7r0ÿ‡+ˆ
`{{‰Šs‹ŠŒŽ‘A’z“““”|•w”A{
`TUVWXYZ[ÿ]^ÿƒ„Tbƒÿmdld…ÿfgX]TbZVÿhZiZjkZÿclmndledmop
`>:q7r+*
`'565–7).8.2<)—ÿ˜™0š›˜
`tt{BttNttBu|N{tvutBtuttutvtNt
`TUVWXYZ[ÿ]^ÿœTbZVÿcdmd…ÿfgX]TbZVÿhZiZjkZÿclmndledmop
`'5'™8—+<:—)4ÿž84*:—)
`>:q7r+*
`tvyz@@{@|
`TUVWXYZ[ÿ]^ÿgX]TbZVÿcdmÿfgX]TbZVÿhZiZjkZÿclmndledmop
`'5†Ÿ1r+4ÿ0/+.1232+4,
`>:q7r+*
`'5†567?˜
`v€A}AQ7r+*0;9—:, ÿ;4:¡¢).£ ÿ;¤>¥(70 ÿ›>?ÿ7r+*2<)—,ÿ:./+4ÿ1r+ÿ¤˜7? ÿ›>?ÿ;˜˜¤8¦ ÿ›:489+).ÿ7r+*2<)—,ÿ?¡+.<ˆÿ§›7¨?© ÿ¨)ª)4/8:,ÿ˜:q,1).<+,ÿ;)1)ÿ¢).£ÿ§¨˜;¢© ÿ¨:*).ÿ™+1)q8—8*+ÿ;)1)q),+ÿ§¨™;¢©
`'5†5'«+—)1+/ÿ7?˜
`¬6­®¯­°¯­ÿBKMLMAGHC²MSGIM²DCEPÿKMLMAGHC²JFEN
`³†¯³®¯´ÿBKMLMAGHC²MSGIM²DCEN
`7r+*0;9—:,
`'5†5†;+94+<)1+/ÿ7?˜
`~}‚Ay@A}Pÿ~}‚AQQAPÿ‚vyyA€vA
`7r+*0;9—:,
`'5†5–›:489+).ÿ78**:.21ˆÿ§›7©ÿ(:*q+4
`'­°¯†­'¯®›:489+).ÿ7r+*2<)—,ÿ?¡+.<ˆÿ§›7¨?©
`'5†5°(˜7ÿ(:*q+4
`  
    !   
`
"
 #$%
`
` &
`
`

`

`
`
ÿÿ  ÿÿ

`
`   
`())*)+,-./01
`23*345/11
`6789:;;67<=+>.?-@ÿ1BCDEFBGÿ+HIH
`23*3J+??,KEÿ?LMNIHBODÿ1+
`+,P?1+Q)(RQ44
`S->ÿ+??,KE
`23*3TUFVFWDCFH
`@FCKOHFBDUFVFWDCFH
`23(?XBKBXYN:]^_`abcdefg`hij]k]^:lm]_`gabcdencahdejopabfg`qa
`23(3QZD?[ÿSBI\Xÿ,D\YN
`
`:]:rbk]:sa8copk
`_fepf`ha
`t`qipf`ha
`t`qipf`haÿvfwxihfba
`t`qipf`haÿvfwxihfbaÿ^:yzj
`t`qipf`haÿ{dqwipfwxihfba
`t`qipf`haÿ{dqwipceiw`qa
`t`qipf`haÿsihifpabfba
`t`qipf`haÿsihicdqwipceiw`qa
`t`qipf`haÿsihicdqwipceiw`qalÿsihicdqwfba
`t`qipf`haÿ|}e~fbaÿ^zyzj
`t`hipf`ha
`ZD?[
`23(32+DWKNFIK\ƒ?LWW„FDCÿ?XBKBXYN
`‰\HŠKOHFB
`„FCKOHFBD
`PF„FBHPXOHFBDPX„KIKE0FIKÿKWIHC\DB
`1NFOHFBH@ƒ0HFBD@DKNIDNFB
`Q*JƒRTƒ4
`@FGBKOHFBD
`PX„KOHFBD
`2ƒ†+FDI…X„HYFBK‡ƒ/ƒ†2ˆ4ƒCFYDI…X„W…DBX„‡HODIHYFCD
`ZH\FOHFBD
`@FCHƒZHBI„D
`PX„KOHFB
`@FCKCD\Y
`+H„OHFBD
`PX„KOFIFB
`2ƒ†+FDI…X„HYFBK‡ƒ2Œˆ4ŒƒHODIKEX„FCFCD
`>BDNIHOKB
`SN\HOHFBD
`?K„OHFB1NFOHFBDPX„DNIDNFB
`PX„KBDL\H„ÿ†\DDÿMHND‡
`0LFŠHNF„
`+LBOHFBD
`>„W…HOHFBD
`+DBIFWHIO…
`0HWWFOHFBD
`‹LOHFBH
`ŽDIKOHFBD
`-LM0…DY
`  
    !   
`
"
 #$%
`
`€pbipf`ha
`dea‚bca‚`h
`deipf`ha
`deip`b`h
`deiha}wfe
`@FGBKOHFBLY
`OIKOHFBD
`‹DYFOHFBD
`PF„KOHFBH
`P„„FBH2ƒ+FDI…X„HYFBKƒ/ƒ†2ˆ4ƒCFYDI…X„W…DBX„‡HODIHYFCD
`>ODIHYFCDˆÿ2ƒ†CFDI…X„HYFBK‡ƒ/ƒ†2ˆ4ƒCFYDI…X„W…DBX„‡ƒ
`@FCKOHFBDÿ†>/‡
`+FDI…X„HYFBKHODIKƒ2ˆ4ƒEX„FCFCD
`S@>ƒZHE
`PF„KOHFBHÿ‘1IH„FHB’
`
`H„W…Hƒ+FDI…X„HYFBKƒ2ˆ4ƒCFYD
`@FCKOHFBLYÿ‘1//ƒ@HIFB’
`@FCKOHFBHÿ‘1//ƒ?WHBFN…’
`SZ“@SP
`2Œˆ4Œƒ>ODIKEX„FCFCDˆÿ2ƒ†CFDI…X
`@FCKOHIKB
`H„Hƒ+FDIF„HYFBKƒ2ˆ4ƒCFYDIF„H
`0[S“1”4(R4
`[?+“ÿ**R)
`5/11ƒ•T-12))•TJ
`PX„KOHFBDÿ†,/‡
`
`& '
`
`

`

`()*+,-./0ÿ/23ÿ4*56-./0ÿ4789+7:-+6
`
`
ÿÿ  ÿÿ

`   
`(;<)8,9=:+3ÿ4789+7:-+6
`LBMB?BNOB
`>?@AB?CDÿFGHB
`>?@AB?CDÿIGJKB
`dQceU]SfÿghÿiUgd\Scÿ^ajÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`PQRSTURVWÿYSZ[\]
`^_`a_`ÿ[bcQR
`dQceU]SfÿghÿrsQ[i_ÿ_amÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`rsQ[i_
`^a_
`dQceU]SfÿghÿdVT]xlÿ_a`aoajjÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`thfWQ[SuÿvQufÿwQuQWÿdQUu]
`j
`dQceU]SfÿghÿdVT]xlÿ_a`aoajjÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`thfWQ[SuÿvQufÿyTTSe]QWÿdQUu]
`^
`dQceU]SfÿghÿdVT]xlÿ_a`aoajjÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`zQ]V]VgRSÿvQufÿdQUu]
`{
`dQceU]SfÿghÿiUgd\Scÿ^ajÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`|}VT]ÿPVll
`^_`aj~_^j_ÿ[bcQR
`dQceU]SfÿghÿiUgd\Scÿ^ajÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`PQuQZlQ]QeZTÿPVll
`^_`aj~_^j_ÿ[bcQR
`dQceU]SfÿghÿdVT]xlÿ_a`aoajjÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`QeQRQ[ZTVRÿiQRVWÿ€UWVTSÿyWSV
`_^a_ÿ‚ƒ
`dQceU]SfÿghÿiUgd\Sc
`tSVxhÿy]QcÿdQUu]
`j~
`dQceU]SfÿghÿiUgd\Sc
`„QWcVRÿd\VW[S
`m
`dQceU]SfÿghÿdVT]xlÿ_a`aoajjÿkiUgd\ScÿWSRSVlSÿ^mjnamoajpq
`dQceRS}Z]h
`^^p
`dQceU]SfÿghÿiUgd\Sc
`…lQ]QeSÿy]QcÿdQUu]
`m
`dQceU]SfÿghÿiUgd\Sc
`wSZuSfÿy]Qcÿ€]SWSQTSu]SWÿdQUu]
`m
`dQceU]SfÿghÿiUgd\Sc
`†ufSZuSfÿy]Qcÿ€]SWSQTSu]SWÿdQUu]
`m
`dQceU]SfÿghÿiUgd\Sc
`wSZuSfÿvQufÿ€]SWSQTSu]SWÿdQUu]
`m
`dQceU]SfÿghÿiUgd\Sc
`†ufSZuSfÿvQufÿ€]SWSQTSu]SWÿdQUu]
`m
`dQceU]SfÿghÿiUgd\Sc
`dQxVRSu]Rh‡vQufSfÿ†uZ]ÿdQUu]
`j
`dQceU]SfÿghÿiUgd\ScÿkWSRSVlSÿ^mjnamjam`q
`dQceQUufÿ…lÿdVuQuZTVRZˆSf
`‰Sl
`(;‹Œ9+7-,+2:/0ÿ4789+7:-+6
`4=Š)*+,
`(;‹;<4*56-./0ÿŽ+6.7-9:-82
`€QRZf=,/2ÿ+:/Š808,+ÿŽ/:/Š/6+ÿ‘Ž’“
`(;‹;‹)8087”•87,
`–SSfRSlÿWQcÿŠ+2—+2+ÿQWÿVRTQ\QR
`˜™š›œÿŸ ¡ ÿ¢£ ÿ¤™¥¦ÿ¢§¨©œÿª§«¬™£­®œÿ¯£­°™£±›™œÿ­²ÿ³«¥®œ±£›§´ÿµ§±™£›§´œ ÿ¶¶±·ÿ¸¥›±›­« ÿ¹›´™º»³«±™£œ¼›™«¼™ÿ¹›´™ºÿ½ÿ¢­«œÿ³«¼ ÿ¾­¿­À™«ÿÁ¡ ÿÂÃÃÄ ÿ° ÿ¶ÂÅÆ
`/—/738=6ÿÇ=Š6:/2.+6ÿŽ/:/ÿ’/2Èÿ‘ÇŽ’“
`‰SRRQÉÿuSSfRSlÿWQcÿÉV]SW
`¾§º«™œÿ¹ µ ÿ¤™¥ ¦ ÿʟÊÿ¾§«¥¿­­Àÿ­²ÿÊ·™Ë›œ±£ºÿ§«¥ÿ¯·ºœ›¼œ ÿÆı·ÿ¸¥›±›­« ÿʟÊÿ¯£™œœÿ˜˜ÊÿÌ­¼§ÿŸ§±­«ÍÿΘÿÂöŻÂöĝÿ° ÿÅ»¶ÏÂ
`/—/738=6ÿÇ=Š6:/2.+6ÿŽ/:/ÿ’/2Èÿ‘ÇŽ’“
`Y\Z]SÿQWÿlRZ[\]RhÿhSRRQÉÐÿTWhl]VRRZuSÿeQÉfSW
`˜™š›œÿŸ ¡ ÿ¢£ Ñÿ¾§š´™º©œÿÊ­«¥™«œ™¥ÿÊ·™Ë›¼§´ÿª›¼±›­«§£ºÿ¶Ò±·ÿ¸¥›±›­« ÿ¡­·«ÿ¹›´™ºÿ½ÿ¢­«œÿ³«¼ ÿÁ™šÿÓ­£ÀÿÁÓÿÂÃÃÏ ÿ° ÿÏÒÄ
`/—/738=6ÿÇ=Š6:/2.+6ÿŽ/:/ÿ’/2Èÿ‘ÇŽ’“
`(;‹;(Ô387
`d\VWVT]SWZl]ZTÿQfQW
`˜™š›œÿŸ ¡ ÿ¢£ Ñÿ¾§š´™º©œÿÊ­«¥™«œ™¥ÿÊ·™Ë›¼§´ÿª›¼±›­«§£ºÿ¶Ò±·ÿ¸¥›±›­« ÿ¡­·«ÿ¹›´™ºÿ½ÿ¢­«œÿ³«¼ ÿÁ™šÿÓ­£ÀÿÁÓÿÂÃÃÏ ÿ° ÿÏÒÄ
`/—/738=6ÿÇ=Š6:/2.+6ÿŽ/:/ÿ’/2Èÿ‘ÇŽ’“
`(;‹;Ւ8-0-2Öÿ48-2:
`j{n‡jomÿ×dÿV]ÿ^amm|Ømmÿccÿt[
`¯·ºœ¯£­°Ž7=֒/2È
`  
    !   
`
"
 #$%
`
`& '
`
`

`

`
`
ÿÿ  ÿÿ

`   
`'(')*+,-./ÿ123.4565-2ÿ7.3.4.82ÿ9+17:;
`<=>=?1263@/AÿB5@/3
`C(DEÿ)*GHIJGKLM7N,A:./O
`C(DEÿ)*PBQÿ7RRS5T
`C(ÿ)*UVIWXJYÿ[\]\ÿ^X_\`\ÿabaÿUVW_cLLdÿLeÿaHXfgJhKIÿVW_ÿGHIJgiJ\ÿjkhHÿl_ghgLW\ÿabaÿGKXJJÿmmaYÿnLiVÿbVhLWoÿpmÿqrstuqrskYÿM\ÿtusvq
`+.w.Nx5,8ÿR,483./y28ÿ7.3.ÿ:./Oÿ9+R7:;
`C(DE)*+,-./ÿ123.4565-2ÿ7.3.4.82ÿ9+17:;
`<=>=zR56,4@6@3{
`|}~ÿ€‚ƒ„„…†ÿ€‡ÿˆÿ‚ƒ…ˆ‰Š~ÿ„ÿ…}~ÿˆ‹€‚‰…ÿ€‡ÿ…}ˆ…ÿ‚ƒ…ˆ‰Š~ÿ…}ˆ…ÿŒ„ÿ„€Ž~ÿ„‰ÿˆÿ„Ž~‰ÿˆ‹€‚‰…ÿ€‡ÿ€Ž~‰…Dÿ|}~ÿ~‡ˆ‚…ÿ€Ž~‰…ÿ„ÿŒˆ…~‘ÿ„‡ÿ‰€…ÿ„‰„Šˆ…~D
`’'““ÿ‹”•ÿ–ˆ…ÿ—“ÿ)*˜
`™šm›œ[›™YUÿžÿŸš  l plmlbYb]ÿ^sjjq`
`7N,A:./O
`¡¢£¤¥¦§ÿ7N,A:./O
`©¦¥¢¤ªÿ«¬­¦§ÿ•„€Šˆ„‰~
`®©¯§ÿ°33±²³³´´´=xN,A4./O=y.³xN,A8³7:µµ>¶·
`¸¦¹¥¤º»¼º¢½§ÿ|}~ÿ¾‚¿ˆ‰Àÿˆ…ˆƒˆ~ÿ„ÿˆÿ‚‰„Á‚~ÿƒ„€„‰‡€‹ˆ…„Šÿˆ‰ÿŠ}~‹„‰‡€‹ˆ…„Šÿ~€‚Š~ÿ…}ˆ…ÿŠ€‹ƒ„‰~ÿ~…ˆ„~ÿ‚ÿ–„D~DÿŠ}~‹„Šˆ‘ÿÂ}ˆ‹ˆŠ€€„Šˆÿˆ‰ÿÂ}ˆ‹ˆŠ~‚…„Šˆ˜ÿˆ…ˆÿŒ„…}
`Š€‹Â~}~‰„Ž~ÿ‚ÿ…ˆ~…ÿ–„D~Dÿ~Á‚~‰Š~‘ÿ…‚Š…‚~‘ÿˆ‰ÿˆ…}Œˆ†˜ÿ„‰‡€‹ˆ…„€‰D
`¯º¥¦½¹¦ÿ«¢¼¦§ÿ*~ˆ…„Ž~ÿ*€‹‹€‰Ãÿą…„ƒ‚…„€‰Åƀ‰*€‹‹~Š„ˆÿ’D“ÿlj…~‰ˆ…„€‰ˆÿ•„Š~‰~ÿ–}……ÂȔ”Š~ˆ…„Ž~Š€‹‹€‰D€”„Š~‰~”ƒ†Å‰Š”’D“”~ˆŠ€~˜
`¯º¥¦½¹¦ÿ®©¯§ÿ°33±8²³³´´´=xN,A4./O=y.³62A.6³32N-8É5ÊÉ,82
`“D“Ëÿ̙šm›œ[›™YUÿžÿŸš  l plmlbYb]ÿ^sjjq`
`PBQÿ7RRS5T
`¡¢£¤¥¦§ÿPBQÿ7RRS5T
`©¦¥¢¤ªÿ«¬­¦§ÿ•„€Šˆ„‰~
`®©¯§ÿ°33±8²³³y5-±35T=2±.=A5ͳx.8°45.Nx³7SÎRÏ7·µÐ?·zz
`¸¦¹¥¤º»¼º¢½§ÿ¾ÑÑ|€Òÿ€Ž„~ÿˆÿ}„}ÿÁ‚ˆ„…†ÿ‚ƒ„ŠÿŠ}~‹„…†ÿ~€‚Š~ÿ‡€ÿ‚€…„‰ÿ„‹Â€Ž~ÿ~„Š…„Ž~ÿ…€Ò„Š€€†D
`¯º¥¦½¹¦ÿ®©¯§ÿ°33±8²³³´´´=2±.=A5ͳ±N@Í.y{³±N@Í.y{Ó.y3Ó6.´8Ó±56@y@28Ó./xÓN285,Ny28
`ljÿ´.32N‘ÿ’'“ÿ‹”•ÿˆ…ÿ—“ÿ)*
`™VÔdLÕJdIYÿ\U\YÿUXYÿ™VWYÿÖVgWYÿG\ÿUVW_cLLdÿLeÿš×ØXLØJÿLÔØcgÔghIÿŸVhVÿXiLW_ÿl_ghgLW\ÿabaÿGKXJJYÿnLiVÿbVhLWYÿpmÿqrsrYÿM\ÿsrtr
`+.w.Nx5,8ÿR,483./y28ÿ7.3.ÿ:./Oÿ9+R7:;
`¡¢£¤¥¦§ÿ+.w.Nx5,8ÿR,483./y28ÿ7.3.ÿ:./Oÿ9+R7:;
`©¦¥¢¤ªÿ«¬­¦§ÿ•Ç¾Ù*ÄÇÆÚ
`®©¯§ÿ°33±8²³³±,4y°2-=/y4@=/6-=/@°=A5ͳ85,Ny2³°8x4³<<?µ
`¸¦¹¥¤º»¼º¢½§ÿ|}~ÿۈ܈€‚ÿтƒ…ˆ‰Š~ÿ¾ˆ…ˆÿ¿ˆ‰Àÿ–ÛѾ¿˜ÿ„ÿˆÿ…€Ò„Š€€†ÿˆ…ˆƒˆ~ÿ…}ˆ…ÿ‡€Š‚~ÿ€‰ÿ…}~ÿ…€Ò„Š€€†ÿ€‡ÿ€…~‰…„ˆ†ÿ}ˆÜˆ€‚ÿŠ}~‹„ŠˆDÿDžÿ€Ž„~ÿ„‰‡€‹ˆ…„€‰ÿ€‰ÿ}‚‹ˆ‰ÿ~Ò€‚~‘
`„‰‚…„ˆÿ}†„~‰~‘ÿ~‹~~‰Š†ÿ}ˆ‰„‰ÿ€Š~‚~‘ÿ~‰Ž„€‰‹~‰…ˆÿ‡ˆ…~‘ÿ~‚ˆ…€†ÿ~Á‚„~‹~‰…‘ÿ‰ˆ‰€‹ˆ…~„ˆ‘ÿˆ‰ÿ~ˆ…~ÿˆ~ˆDÿ|}~ÿ„‰‡€‹ˆ…„€‰ÿ„‰ÿÛѾ¿ÿ}ˆÿƒ~~‰ÿˆ~~ÿƒ†ÿˆÿъ„~‰…„‡„Š
`Ý~Ž„~Œÿވ‰~D
`ß~†ÿ€‚ƒ~ÿ„‰ÿˆŠ€}€‘ÿy°65N5Ê5N-àÿ‡~~†ÿ€‚ƒ~ÿ„‰ÿ~…}~‘ÿ42/w2/2Dÿ¾„€Ž~ÿ„‰ÿ€„
`œá XgÔYÿ]\Ö\ÿ^X_\`\ÿâHXÿ]XKidÿãW_XäÿuÿšWÿlWiIiÔLMX_gVÿLeÿaHXfgiVÔJYÿŸKØåJYÿVW_ÿngLÔLågiVÔJ\ÿaVfcKg_åXYÿæ›oÿbLIVÔÿLigXhIÿLeÿaHXfgJhKIYÿqrst\YÿM\ÿsrsj
`+.w.Nx5,8ÿR,483./y28ÿ7.3.ÿ:./Oÿ9+R7:;
`¡¢£¤¥¦§ÿ+.w.Nx5,8ÿR,483./y28ÿ7.3.ÿ:./Oÿ9+R7:;
`©¦¥¢¤ªÿ«¬­¦§ÿ•Ç¾Ù*ÄÇÆÚ
`®©¯§ÿ°33±8²³³±,4y°2-=/y4@=/6-=/@°=A5ͳ85,Ny2³°8x4³<<?µ
`¸¦¹¥¤º»¼º¢½§ÿ|}~ÿۈ܈€‚ÿтƒ…ˆ‰Š~ÿ¾ˆ…ˆÿ¿ˆ‰Àÿ–ÛѾ¿˜ÿ„ÿˆÿ…€Ò„Š€€†ÿˆ…ˆƒˆ~ÿ…}ˆ…ÿ‡€Š‚~ÿ€‰ÿ…}~ÿ…€Ò„Š€€†ÿ€‡ÿ€…~‰…„ˆ†ÿ}ˆÜˆ€‚ÿŠ}~‹„ŠˆDÿDžÿ€Ž„~ÿ„‰‡€‹ˆ…„€‰ÿ€‰ÿ}‚‹ˆ‰ÿ~Ò€‚~‘
`„‰‚…„ˆÿ}†„~‰~‘ÿ~‹~~‰Š†ÿ}ˆ‰„‰ÿ€Š~‚~‘ÿ~‰Ž„€‰‹~‰…ˆÿ‡ˆ…~‘ÿ~‚ˆ…€†ÿ~Á‚„~‹~‰…‘ÿ‰ˆ‰€‹ˆ…~„ˆ‘ÿˆ‰ÿ~ˆ…~ÿˆ~ˆDÿ|}~ÿ„‰‡€‹ˆ…„€‰ÿ„‰ÿÛѾ¿ÿ}ˆÿƒ~~‰ÿˆ~~ÿƒ†ÿˆÿъ„~‰…„‡„Š
`Ý~Ž„~Œÿވ‰~D
`р‚ƒ~ÿ„‰ÿˆŠ€}€‘ÿ~…}~‘ÿ€ÿy°65N5Ê5N-
`mXÕgJYÿb\Ö\ÿK\çÿUVÕÔXIáJÿaLW_XWJX_ÿaHXfgiVÔÿŸgihgLWVKIÿsèhHÿl_ghgLW\ÿÖLHWÿ[gÔXIÿžÿLWJYÿãWi\ÿ XÕÿ™LKdYÿ ™ÿqrrv\YÿM\ÿvèk
`  
    !   
`
"
 #$%
`
`& &
`
`

`

`
`
ÿÿ  ÿÿ

`   
`()*)+,-./ÿ1.2/3)456/ÿ7)3)ÿ8)49ÿ:(178;
`<=>?@ABÿ()*)+,-./ÿ1.2/3)456/ÿ7)3)ÿ8)49ÿ:(178;
`DA@=?EÿFGHABÿIJKLMNJOP
`QDRBÿS33T/UVVT.25S6WX452YX4ZWX4YSX[-\V/-.+56VS/,2V]]^_
``Aa@?bcdb=eBÿfghÿjklkmnopqÿrpsqtkuvhqÿKktkÿwkuxÿyjrKwzÿ{qÿkÿto|{vo}o~ÿnktkskqhÿtgktÿ€ovpqhqÿouÿtghÿto|{vo}o~ÿo€ÿothut{k}}ÿgklkmnopqÿvgh‚{vk}qƒÿJtÿmo„{nhqÿ{u€om‚kt{ouÿouÿgp‚kuÿh|oqpmh…
`{unpqtm{k}ÿg~{huh…ÿh‚hm~huvÿgkun}{u~ÿmovhnpmhq…ÿhu„{mou‚hutk}ÿ€kth…ÿmh~p}ktomÿmh†p{mh‚hutq…ÿukuo‚kthm{k}q…ÿkunÿmh}kthnÿkmhkqƒÿfghÿ{u€om‚kt{ouÿ{uÿjrKwÿgkqÿshhuÿkqqhqqhnÿsÿkÿrv{hut{€{v
`‡h„{hˆÿ‰kuh}ƒ
`Šhmÿqo}ps}hÿ{uÿ264*646…ÿ63S‹Zÿ63S6+…ÿ63S)4-Z…ÿkunÿ5SZ-+-Œ-+W
`Ž‘’“ÿ•–—–ÿ˜‘™–š–ÿ›œ›ÿŽ™žžŸÿž ÿ›¡‘¢£’¤¥ÿŽ™ÿ¦¡’£§’–ÿ¨©¤¡ÿª™£¤£ž–ÿ›œ›ÿ¦¥‘’’ÿ««›“ÿ¬ž§ŽÿœŽ¤ž­ÿ®«ÿ¯°±²³¯°±©“ÿ´–ÿ²³±µ¯
`()*)+,-./ÿ1.2/3)456/ÿ7)3)ÿ8)49ÿ:(178;
`<=>?@ABÿ()*)+,-./ÿ1.2/3)456/ÿ7)3)ÿ8)49ÿ:(178;
`DA@=?EÿFGHABÿIJKLMNJOP
`QDRBÿS33T/UVVT.25S6WX452YX4ZWX4YSX[-\V/-.+56VS/,2V]]^_
``Aa@?bcdb=eBÿfghÿjklkmnopqÿrpsqtkuvhqÿKktkÿwkuxÿyjrKwzÿ{qÿkÿto|{vo}o~ÿnktkskqhÿtgktÿ€ovpqhqÿouÿtghÿto|{vo}o~ÿo€ÿothut{k}}ÿgklkmnopqÿvgh‚{vk}qƒÿJtÿmo„{nhqÿ{u€om‚kt{ouÿouÿgp‚kuÿh|oqpmh…
`{unpqtm{k}ÿg~{huh…ÿh‚hm~huvÿgkun}{u~ÿmovhnpmhq…ÿhu„{mou‚hutk}ÿ€kth…ÿmh~p}ktomÿmh†p{mh‚hutq…ÿukuo‚kthm{k}q…ÿkunÿmh}kthnÿkmhkqƒÿfghÿ{u€om‚kt{ouÿ{uÿjrKwÿgkqÿshhuÿkqqhqqhnÿsÿkÿrv{hut{€{v
`‡h„{hˆÿ‰kuh}ƒ
`¶ƒ·¸h¹º»ÿ~¼I(.W)4ÿ½63)2-Z-W6ÿ7)3)2)/6ÿ:(½78;
`<=>?@ABÿ(.W)4ÿ½63)2-Z-W6ÿ7)3)2)/6ÿ:(½78;
`DA@=?EÿFGHABÿI{novk{uh
`QDRBÿS33TUVV¾¾¾XSW,2X5)VW63)2-ZY36/V(½78__¿ÀÀÁÂ
``Aa@?bcdb=eBÿfghÿjp‚kuÿÃhtkso}o‚hÿKktkskqhÿyjÃKwzÿ{qÿkÿ€mhh}ÿk„k{}ks}hÿh}hvtmou{vÿnktkskqhÿvoutk{u{u~ÿnhtk{}hnÿ{u€om‚kt{ouÿksoptÿq‚k}}ÿ‚o}hvp}hÿ‚htkso}{thqÿ€opunÿ{uÿtghÿgp‚kuÿsonƒ
`Rb@AeaAÿF=dABÿjÃKwÿ{qÿo€€hmhnÿtoÿtghÿps}{vÿkqÿkÿ€mhh}ÿk„k{}ks}hÿmhqopmvhƒÿÄqhÿkunÿmh¹n{qtm{spt{ouÿo€ÿtghÿnktk…ÿ{uÿˆgo}hÿomÿ{uÿkmt…ÿ€omÿvo‚‚hmv{k}ÿpmoqhqÿmh†p{mhqÿh|}{v{tÿhm‚{qq{ouÿo€ÿtgh
`kptgomqÿkunÿh|}{v{tÿkvxuoˆ}hn~‚hutÿo€ÿtghÿqopmvhÿ‚kthm{k}ÿyjÃKwzÿkunÿtghÿom{~{uk}ÿps}{vkt{ouÿyqhhÿtghÿjÃKwÿv{t{u~ÿk~hzƒÿÅhÿkqxÿtgktÿpqhmqÿˆgoÿnoˆu}oknÿq{~u{€{vkutÿomt{ouqÿo€ÿtghÿnktkskqh
`v{thÿtghÿjÃKwÿkhmÿ{uÿkuÿmhqp}t{u~ÿps}{vkt{ouqƒ
`Rb@AeaAÿQDRBÿS33TUVV¾¾¾XSW,2X5)V5Y3Y4[
`Ƹ¶ƒÇÿÈp~¼‚IÉ
`1)4Œ-+,Ê8.+4S)WÿË6436+ÿŒ-+ÿËS6WY5)ZÿÌ64-WY5/
`<=>?@ABÿ1)4Œ-+,Ê8.+4S)WÿË6436+ÿŒ-+ÿËS6WY5)ZÿÌ64-WY5/
`DA@=?EÿFGHABÿrJKͶ¶ÎÍÇ
`QDRBÿS33T/UVVT.25S6WX452YX4ZWX4YSX[-\V2Y-)//)‹V¿ÏÏÂÐ/653Y-4Ñ7)3)ÊÒ)2Z6
``Aa@?bcdb=eBÿN†phopqÿqo}ps{}{tÿ{uÿsp€€hmÿktÿjÿӃÔ
`]XÁXÕÖ)T-+ÿ×+6//.+6
`΃ÓÎØ»º¹Îÿ‚‚ÿj~ÿktÿǶÿÙMÿyhqtz
`ÚÛÿª¦ÜÝÿª’¤£¢Ž¤£žÿ¦¥žÞ¥Ž¢ÿߐ¤‘¥ Ž§‘ÿ˜ª¦ßšÿÛࣤ‘–ÿᑥ–ÿ©–±±–ÿâžã“ÿ¯°±¯–ÿÜ㎣䎝ä‘ÿ ¥ž¢“ÿŽ’ÿž ÿÜàÞÿ¯å“ÿ¯°±©­ÿæççèéêêëëëìíèîìïðñêðèèçêíòèðóôõíêèôöóêíè÷óô÷çíøùìæçú
`()*)+,-./ÿ1.2/3)456/ÿ7)3)ÿ8)49ÿ:(178;
`]XÁXûü-[×
`ǃÔÔÜáýªª®“Üÿ˜±¨¨µš
`7+.[8)49
`ǃÔÔÿyIo~‰z
`Üáýªª®“Üÿ˜±¨¨µš
`þ×ÿÿ711Ò-
`}o~ÿ oˆÿÿǃÇÎÿktÿjÿӃÔ
`Ž’§¡“ÿ›–“ÿ«‘ž“ÿܖ“ÿý–ÿž‘Ÿ¢Ž–ÿª ´äž¥£ÞÿÛܜÿ³ÿ™¥ž´¡ž£§“ÿªä‘§¤¥ž£§“ÿŽ™ÿÛ¤‘¥£§ÿ›ž’¤Ž¤’–ÿ•Ž’¡£Þ¤ž“ÿý›­ÿÜ¢‘¥£§Žÿ›¡‘¢£§Žäÿ۞§£‘¤–“ÿ±¨¨å–“ÿ´–ÿ±¯
`()*)+,-./ÿ1.2/3)456/ÿ7)3)ÿ8)49ÿ:(178;
`ǃ»(.W)4ÿ½63)2-Z-W6ÿ7)3)2)/6ÿ:(½78;
`]XÁXÏü-[1
`¹»ƒÓÎÜý—ªÿœ‘’‘Ž¥§¡“ÿÚۛý
`7+.[8)49
`  
    !   
`
"
 #$%
`
`& '
`
`

`

`
`
ÿÿ  ÿÿ

`   
`'()(*+,-./010-23,4516ÿ8065
`9:;;<=>?@AABÿ@D@?A@EA<ÿF:AGH?:IFÿ:Jÿ10KLM.0N5ÿ42KOLM41LO0K5ÿ?IÿPQÿK5R-OLS5ÿGFG@AABÿ@=<ÿFH@EA<ÿJ:=ÿTUÿ;:IHVFÿ@JH<=ÿHV<ÿW@H<ÿ:Jÿ;@IGJ@>HG=<Xÿ9:;;<=>?@AABÿ@D@?A@EA<ÿF:AGH?:IFÿ:J
`10KLM.0N5ÿ42KOLM41LO0K5ÿ?IÿPQÿK5R-OLS5ÿ;@BÿE<ÿY=:D?W<Wÿ?IÿYA@FH?>ÿ>:IH@?I<=FX
`Z[\]^_`aÿcd_^\efÿdgÿh\`iejkcfle\[ÿmj`][`_^lelÿnopqrÿs]tuÿvagd][`e^daÿnopqwÿx\ej\ly`zÿ{swÿnopqzÿ|wÿp}~
`€..OKL‚Sÿ,‚/S-.NM5Sÿƒ.-.ÿ„.N…ÿ†€,ƒ„‡
`ˆH@EA<ÿGIW<=ÿ=<>:;;<IW<WÿFH:=@‰<ÿ>:IW?H?:IFX
`c^u[`kZiy]^_jrÿ{`e\]^`iÿc`g\efÿs`e`ÿcj\\eÿgd]ÿŠ^yd_`^a\wÿm]dyt_eÿ‹t[Œ\]ÿŠpon}zÿŽ\]l^daÿwnÿ‘\’^l^daÿs`e\ÿo}“n“nopq”wÿZ’`^i`Œi\ÿg]d[zÿ`lÿdgÿ•_edŒ\]ÿzÿnopqÿ–——˜™šš›››œžŸ ¡¡¢£¤ž¥–œ¥¦ š¡§¨—©ª
`¥¨«—¨¤œ–— ¢€..OKL‚Sÿ,‚/S-.NM5Sÿƒ.-.ÿ„.N…ÿ†€,ƒ„‡
`'()(**ƒ5ML¬­LS0-0LN
`®V<IÿV<@H<WÿH:ÿW<>:;Y:F?H?:Iÿ?Hÿ<;?HFÿH:¯?>ÿJG;<Fÿ:Jÿ°I?H=:‰<Iÿ:¯?W<F°X
`Š\±^lzÿ‘w²wÿc]wÿ\y”ÿc`³´lÿs`au\]dtlÿm]d|\]e^\lÿdgÿvaytle]^`iÿ{`e\]^`ilwÿppejÿµy^e^dawÿ¶^i\fkvae\]l_^\a_\zÿ¶^i\fÿ·ÿcdalzÿva_wÿhdŒd¸\azÿ‹²wÿnooqwzÿ|wÿpn¹~
`€..OKL‚Sÿ,‚/S-.NM5Sÿƒ.-.ÿ„.N…ÿ†€,ƒ„‡
`'()(*)º.ML)ÿ»5O¬5./010-2
`¼½X¾TZs{µÿ‘\l\`]_jzÿ¿cÀs
`ƒO‚Á„.N…
`'()(*'­Â.
`UXÃTcZ‹Äcŵ‘ÿp~~q”
`ƒO‚Á„.N…
`'()(*ƃ0SSLM0.-0LNÿºLNS-.N-S
`YÇ@ÿÈÿÉXUÊ
`•ldizÿZwÿ\yw”wÿ‘\[^aueda´lÿmj`][`_\te^_`iÿc_^\a_\lwÿp}ejÿ\ywÿµ`ledazÿm\aalfi’`a^`ÿ{`_¸ÿmtŒi^lj^auÿÀdwzÿp~owzÿ|wÿ~~q
`€..OKL‚Sÿ,‚/S-.NM5Sÿƒ.-.ÿ„.N…ÿ†€,ƒ„‡
`'()(*˺L110S0LNÿºOLSSÿ,5M-0LN
`TPÉXÉÿÌÍÿÎÏÐÑÒÿÎ99ˆÿÓBY<ÔÿÓ®ÕÿÏ<HV:WÔÿÏ@Ö:=ÿÏ?¯ÿ×ψ°Ó:Jÿ9@A?E=@H?:IÿÇ?HÿØ®@H<=FÙÒ
`ÐÐ
`–——˜™šš›››œ¥ž¨«¥¨£ž¤¨¥—œ¥¦ š¥ž¨«¥¨š¡¤—ž¥¢¨š˜žžšÚÛÛÜÝÞßàáÝâáÛÝâÞã
`ºº,/.S5
`TPUXä¾ÿÌÍÿÎÏÐÑÒ
`c}pÿåÿ¿²vÀÀcŠvxÿåÿÀdii^l^daÿÀ]dllÿc\_e^daÿÀÀc”ÿŠ^Œ]`]fÿg]d[ÿ¿²vÿåÿæçè™ÝۜéÜâݚꨫ¦£¦œáéãÞãàß
`ëìíîïëÿ,‚S­5M-ÿ80S-ÿðRM4.NÁ5
`'()(*ñÂLò.-Sÿí5-5N-0LNÿóNK5R
`TUÉÃÕÿTUUTÕÿTUU½ÕÿTUÿUÕÿTUPÉÕÿTUÊPÕÿTUÉPÕÿTUÉPÕÿTUÉPÕÿTUÉPÕÿTUÉPÕÿTUUÃÕÿTUUÃÕÿTUUÃÕÿTUUÃÕÿTUUÃÕÿTUUÃÕÿTUUÃÕÿTUUTÕÿTUU¾ÕÿTUU¾ÕÿTUU¾ÕÿTUU¾ÕÿTUU¾ÕÿTUUPÕÿTUUPÕÿTUUPÕ
`TUUPÕÿTUUPÕÿTUUPÕÿTUUPÕÿTUUPÕÿTUäÃÕÿTUäÃÕÿTUäÃÕÿTUäÃÕÿTUäÃÕÿTUä¾ÕÿTUäÿÕÿTUäPÕÿTUäPÕÿTUäPÕÿTUP½ÕÿTUP¾ÕÿTU½UÕÿTUP½ÕÿTUÊÃÕÿTUÊÿÕÿTU½¾ÕÿTUÊPÕÿTUÉPÕÿTUÉPÕÿTUU¾ÕÿTUÉPÕ
`ôõö÷øöùøÿ÷û÷üýûþöù
`TUPÃÕÿTäÃÃÕÿTUÊäÕÿTUPäÕÿTUÊÊÕÿTUÊÃÕÿTUUPÕÿTUÉPÕÿTUÉÊXäÕÿTU½TÕÿTU½¾ÕÿTUÉÃÕÿTUPÊÕÿTU½½ÕÿTU½¾ÕÿTUP¾ÕÿTUP½ÕÿTUPÊÕÿTUPÉÕÿTUPÉÕÿTUPUÕÿTUPUÕÿTUÊÃÕÿTUÊÃÕÿTUÉÃÕÿTUÊPÕÿTUÊP
`ô ü õö÷øöùøÿ÷û÷üýûþöù
`Tä¾½ÕÿTä¾½ÕÿTUUPXäÕÿTUÉPX¾ÕÿTUɾXÉÕÿTUUTXTÕÿTU½¾ÕÿTUÉTXÿ
`ëó,ÿî.SSÿ,­5M-OL¬5-O2ÿƒ.-.ÿº5N-5O
`'()(*ì-45OÿðR­5O0¬5N-.1ÿ»OL­5O-05S
`ÔÿTUüTU¾ÿ9ÿ@Hÿ½ÿ;;ÿщ ÿTPä¼TÊÃÿ9ÿ@Hÿ¾ÿ;;ÿщ
`•´‹\^izÿ{w²wÿ\yw”wÿÅj\ÿ{\]_¸ÿvay\³ÿkÿZaÿµa_f_id|\y^`ÿdgÿÀj\[^_`ilzÿs]tulzÿ`ayÿx^didu^_`ilwÿÀ`[Œ]^yu\zÿ¿
`ÿ‘df`iÿcd_^\efÿdgÿÀj\[^le]fzÿnop¹wzÿ|wÿpop~
`€..OKL‚Sÿ,‚/S-.NM5Sÿƒ.-.ÿ„.N…ÿ†€,ƒ„‡
`
`
ˆˆ ÿˆ×ÑÓÿ×ÓÓ ÿÓˆÓÿ°8óƒìºïóëðÿ€ƒí캀8ìíóƒð°
`  
    !   
`
"
 #$%
`
` &
`
`

`

`   
`
`
ÿÿ  ÿÿ

`'()*+ÿ-.ÿ/01.2.ÿ3045678)69(ÿ:;<=4<>0?85><*ÿ@>506>0(.ÿAB8;ÿ01.ÿC<(8)6+ÿ:066(D*E<65<FÿG<>Hÿ:?I*5(;567ÿJ).+ÿAKLM.+ÿN.ÿKKO
`PQRQSTUVWÿYVZW[Q\]^Wÿ_Q[Qÿ`Q\aÿbPY_`c
`defgÿijkÿlmÿnkopÿijkÿlmÿqPrstsustvpÿlmijkÿlmÿewxefpÿyxlweÿofgiwnkklmeÿzjy{efÿ|r}_sq~}€ÿP_tsqPrst}_€|
`'()*+ÿ-.ÿ/01.2.ÿ3045678)69(ÿ:;<=4<>0?85><*ÿ@>506>0(.ÿAB8;ÿ01.ÿC<(8)6+ÿ:066(D*E<65<FÿG<>Hÿ:?I*5(;567ÿJ).+ÿAKLM.+ÿN.ÿKK‚
`PQRQSTUVWÿYVZW[Q\]^Wÿ_Q[Qÿ`Q\aÿbPY_`c
`yƒ„…†ÿ‡ˆ‰Š…‹ŒŠÿŽÿ‘’“‘”ÿ•opÿŽ–—–ƒ‰˜ˆ‹…†ÿŽÿ’’“’™ÿ•ošÿd†ˆ‰ÿŠ–Œ›œŒ†ÿ„—ÿQ[^Sÿ‹Œ‡–ƒ–ŒpÿŠ–Œ›œŒ†ÿ„—ÿ]žŸUSU US¡šÿl—Š–Œ›œŒ†ÿ„—ÿ†…ƒ†ˆšÿ|r¢TU]Q¢\^ÿž£TSU]žŸUS¢T^|
`'9¤05*+ÿG.¥.ÿ/01.2.ÿ¦;0ÿG0=>Hÿ§610¨ÿ©ÿ-6ÿC6>D>*)N015<ÿ)ªÿJ;045><*(+ÿ«=?7(+ÿ<61ÿ¬5)*)75><*(.ÿJ<4I=5170+ÿ­®Fÿ3)D<*ÿ@)>508Dÿ)ªÿJ;045(8=D+ÿ¯MA°.+ÿN.ÿAMAK
`PQRQSTUVWÿYVZW[Q\]^Wÿ_Q[Qÿ`Q\aÿbPY_`c
`x†—ˆ‰±Šÿk‹²ÿ‡–—Š…‹—…ÿ³ÿš´µ¶“¶ÿ‹…Ž“‡›ÿŽ|Ž–Œÿ‹…ÿ‘·ÿ•oÿ¸†Š…¹
`­@ÿC:-ºÿC(854<85)6ÿ:=)7=<4ÿ§680=ª<>0ÿ/C:§2ÿ@?580.ÿ»0=.ÿO.AA.ÿ¤)E+ÿ¯MA¯.ÿ-E<5*<I*0ÿª=)4+ÿ<(ÿ)ªÿ-?7ÿ¯‚+ÿ¯MAOFÿ¼½½¾¿ÀÀÁÁÁÂþÄÂÅÆÇÀƾ¾½ÀÃȾÆÉÊËÃÀ¾ÊÌÉÀþÍÉÊͽÃÎϼ½Ð
`PQRQSTUVWÿYVZW[Q\]^Wÿ_Q[Qÿ`Q\aÿbPY_`c
`x‰˜ˆ–щŒÿˆ‹˜„‡‹Œÿˆ†‹‡…„–—ÿˆ‹…†ÿ‡–—Š…‹—…ÿ³ÿš¶”µ¶“¶ÿ‡›ÿ‡Ž|Ž–Œ†‡“Š†‡ÿ‹…ÿ‘·ÿ•oÿ¸†Š…¹
`­@ÿC:-ºÿC(854<85)6ÿ:=)7=<4ÿ§680=ª<>0ÿ/C:§2ÿ@?580.ÿ»0=.ÿO.AA.ÿ¤)E+ÿ¯MA¯.ÿ-E<5*<I*0ÿª=)4+ÿ<(ÿ)ªÿ-?7ÿ¯‚+ÿ¯MAOFÿ¼½½¾¿ÀÀÁÁÁÂþÄÂÅÆÇÀƾ¾½ÀÃȾÆÉÊËÃÀ¾ÊÌÉÀþÍÉÊͽÃÎϼ½Ð
`ÒÓÒYÔS¢\Õ^SvQ[^S¢QŸWÿÖSUÔ^S[¢^W
`PQRQSTUVWÿYVZW[Q\]^Wÿ_Q[Qÿ`Q\aÿbPY_`c
`V]Ÿ^QSÿ×VQTSVÔUŸ^ÿS^WU\Q\]^ÿWÔ^][SUW]UÔ£
`ØVQTSVÔUŸ^ÿ]UVԟ¢\Õ
`YÔS¢\Õ^SvQ[^S¢QŸW
`
`  
    !   
`
"
 #$%
`
` &
`
`

`

`O O
`
` CT
`
`O U
`
`O U
`
`O r
`
`11/74
`
` &
`
`11/19/2020
`
`Lidocaine C14H22N20 - PubChem
`
`4 Spectral Information
`
`4.1 1D NMR Spectra
`
`1D NMR Spectra
`
`1D NMR Spectrum 2235 - Lidocaine (HMDB0014426)
`
`1D NMR Spectrum 2930 - Lidocaine (HMDB0014426)
`
`Human Metabolome Database (HMDB)
`
`4.1.1 1H NMR Spectra
`
`Instrument Name
`
`Varian A -60D
`
`Copyright
`
`Copyright © 2009 -2018 Bio -Rad Laboratories, Inc. All Rights Reserved.
`
`Thumbnail
`
`Preview: Most Downfield Peak 120x zoom)
`
`9.2
`
`8.8
`ppm
`Copr. © 2009 -2018 Bio -Rod. All Rights Reserved.
`
`8.6
`
`8.4
`
`I SpectraBase
`
`4.1.2 13C NMR Spectra
`
`Source of Sample
`
`Aldrich Chemical Company, Inc., Milwaukee, Wisconsin
`
`Copyright
`
`Copyright © 1980, 1981 -2018 Bio -Rad Laboratories, Inc. All Rights Reserved.
`
`Thumbnail
`
`BiO'RAD
`Preview: Tallest 'eak Ox zoom)
`
`'()*+,-./ÿ1234-5.,642
`   
`
`
ÿÿ  ÿÿ

`'7889ÿ:;<ÿ()*+,-.
`89ÿ:;<ÿ()*+,-J5ÿKKLMÿNÿO6P4+.62*ÿQR;9STT8''KUV
`=>ÿ@ABÿCDEFGHI
`89ÿ:;<ÿ()*+,-J5ÿKWLTÿNÿO6P4+.62*ÿQR;9STT8''KUV
`RJ5.2ÿ;*,.X4/45*ÿ9.,.X.Y*ÿQR;9SV
`'78788Rÿ:;<ÿ()*+,-.
`Z[\GH]^E[Gÿ@I^E
`_`ab`cÿefghi
`jkDlHmnoG
`pqrsabtuvÿwÿxhhyfxhz{ÿ|bqf}`~ÿ`€qa`vqab‚ƒÿ„c…†ÿe‡‡ÿ}btuv‚ÿ}‚aˆ~†
`‰o]^Š[Im‹
`()*+,-.S.Y*
`'787K8LŒÿ:;<ÿ()*+,-.
`Ck]HFEÿkÿCI^D‹E
`e‡~ab…uÿpuŽb…`‡ÿpqŽr`csƒÿ„c…†ƒÿb‡`‘’ƒÿ“b‚…qc‚bc
`jkDlHmnoG
`pqrsabtuvÿwÿzy{hƒÿzy{zfxhz{ÿ|bqf}`~ÿ`€qa`vqab‚ƒÿ„c…†ÿe‡‡ÿ}btuv‚ÿ}‚aˆ~†
`‰o]^Š[Im‹
`'7K;.YYÿ()*+,-45*,-”
`()*+,-.S.Y*
`(•4–62—ÿKÿ43ÿL˜6*–ÿ;4-*
`Ck]HFEÿkÿCDEFGH]^
``‚‚ÿ™r…vaqŽvasÿpqŽŽbvvÿqšÿvuÿ›qœb…q‡qtsÿ™…vbqcÿqšÿvuÿeŽab…`cÿe…`~Žsÿqšÿqac‚b…ÿ™…bc…‚
`jkDlHmnoG
`pqrsabtuvÿwÿxhzxfxhz{ÿ|bqf}`~ÿ`€qa`vqab‚ƒÿ„c…†ÿžqavbqc‚ÿraqˆb~~ÿ€sÿee™ƒÿ›qœb…q‡qtsÿ™…vbqc†ÿe‡‡ÿ}btuv‚ÿ}‚aˆ~†
`‰o]^Š[Im‹
`  
    !   
`
"
 #$%
`
`14
`
`12
`
`10
`
`18
`ppm
`Copr. © 1980, 1981 -2018 Bio -Rod. All Rights Reserved.
`
`16
`
`14
`
`Spectra Base
`
`4.2 Mass Spectrometry
`
`Showing 2 of 3 View More U
`
`Source of Spectrum
`
`Mass Spectrometry Committee of the Toxicology Section of the American Academy of Forensic Sciences
`
`Copyright
`
`Thumbnail
`
`Copyright © 2012 -2018 Bio -Rad Laboratories, Inc. Portions provided by AAFS, Toxicology Section. All Rights Reserved.
`
`https : / /pubchem.ncbi.nlm.nih.gov/ compound /Lidocaine#section = Solubility
`
`

`

`O U
`
`12/74
`
` &
`
`   
`'()*+,-.-/)
`012345ÿ17ÿ0854932:
`T18U3VWX9
`hX2:ijkVl
`'()*+,-.-/)
`mnonpqrst'
`'uvwxyzÿoÿv|ÿ}~x)wÿtv,)
`€0hÿ2:i53
`ƒVi3k3U
`h19klÿ„5k…†
`:ˆ‰ÿh18ÿ„5k…
`:ˆ‰ÿŠj‹ÿŒVWX5†9
`:ˆ‰ÿ3‹ÿŒVWX5†9
`hX2:ijkVl
`'‘ÿt-//ÿ'()*+,v’)+,“ÿ”-+-ÿr)y+),
`€0hÿ2:i53
`Z‡[‚[
`ƒVi3k3U
``A@NIB<CAÿNIbD<DG
`  
    !   
`
"
 #$%
`h19kl„5k…†
`\Z\
`
`Mass Spectrometry Committee of the Toxicology Section of the American Academy of Forensic Sciences
`
`Copyright ® 2012 -2018 Bio -Rad Laboratories, Inc. Portions provided by AAFS, Toxicology Section. All Rights Reserved.
`
`BIO ,RAD
`Preview: Tallest 'eak (20x zoom)
`
`8 m
`
`84
`
`8
`
`fz
`Copr. S12012 -2018 Bis -Rad. Portions provided by AAFS. All Rights Reserved.
`
`408610
`
`Main library
`
`[^‚\[
`;<IPÿNIbD<DG
`^‡
`^‚
`‡^
`^Ž
`
`85
`
`86
`
`58
`
`87
`
`100
`
`80
`
`60
`
`40
`
`20
`
`0.0
`
`55
`
`60
`
`Lidocalne
`EI mass spectrum, top peaks displayed
`
`65
`
`70
`
`75
`
`80
`
`85
`
`90
`
`mlz
`® 2014 by the U S Secretary of Commerce.
`
`NIST Mass Spectrometry Data Center
`
`NIST Number
`
`Library
`
`250604
`
`Replicate library
`
`https : / /pubchem.ncbi.nlm.nih.gov/ compound /Lidocaine#section = Solubility
`
`Lidocaine C14H22N2O - PubChem
`
`BfID .RAD
`Preview Tallest
`eak (20x zoom)
`
`
`
ÿÿ  ÿÿ

`;<==ÿ?@ABCDEFACDGÿHEFFICCAAÿEJÿCKAÿLEMIBENEOGÿ?ABCIEPÿEJÿCKAÿQFADIB<PÿQB<RAFGÿEJÿSEDAP=IBÿ?BIAPBA=
`HE@GDIOKCÿYÿZ[\Z]Z[\^ÿ_IE]`<Rÿa<bED<CEDIA=cÿdPBeÿfEDCIEP=ÿ@DEgIRARÿbGÿQQS?cÿLEMIBENEOGÿ?ABCIEPeÿQNNÿ`IOKC=ÿ`A=ADgARe
`
`11/19/2020
`
`1 SpectraBase
`
`Source of Spectrum
`
`Copyright
`
`Thumbnail
`
`SpectraBase
`
`4.2.1 GC-MS
`
`Showing 2 of 6 View More
`
`NIST Number
`
`Library
`
`Total Peaks
`
`m/z Top Peak
`
`m/z 2nd Highest
`
`m/z 3rd Highest
`
`Thumbnail
`
`

`

`232
`89
`A8
`DE
`
`58
`
`30
`
`Lidocaine C14H22N2O - PubChem
`
`
`
ÿÿ  ÿÿ

`
`Lidocaine
`EI mass spectrum, top peaks displayed
`
`30
`
`40
`
`50
`
`60
`
`70
`
`80
`
`90
`
`100
`
`80
`
`60
`
`40
`
`20
`
`0.0
`
`20
`
`mlz
`® 2014 by the U S Secretary of Commerce.
`
`MS -MS Spectrum 442501 - Lidocaine (HMDB0014426)
`
`MJ^MJÿJPQRSTiVÿ[[]dkjÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[]dk]ÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[]dklÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[]dk[ÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[[vrlÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[[vr[ÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`
`MS -MS Spectrum 442502 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442503 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442504 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 444863 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 444864 - Lidocaine (HMDB0014426)
`
`O
`
`13/74
`
`& '
`
`NIST Mass Spectrometry Data Center
`
`4.2.2 MS-MS
`
`Showing 2 of 5 View More Z
`
`MS-MS
`
`MS -MS Spectrum 441033 - Lidocaine (HMDB0014426)
`
`MS -MS Spectrum 441034 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 441035 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442491 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442492 - Lidocaine (HMDB0014426)
`
`MS -MS Spectrum 442493 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442494 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442495 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442496 - Lidocaine (HMDB0014426)
`
`MS -MS Spectrum 442497 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442498 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442499 - Lidocaine (HMDB0014426)
`MS -MS Spectrum 442500 - Lidocaine (HMDB0014426)
`
`Human Metabolome Database (HMDB)
`
`1000329
`
`IT /ion trap
`
`0 M
`
`S2
`
`[M +H]+
`
`235.1805
`
`2 8
`
`6
`
`235
`
`0
`
`NIST Number
`
`Instrument Type
`
`Collision Energy
`
`Spectrum Type
`
`Precursor Type
`
`Precursor m/z
`
`Total Peaks
`
`m/z Top Peak
`
`m/z 2nd Highest
`
`m/z 3rd Highest
`
`Thumbnail
`
`https : / /pubchem.ncbi.nlm.nih.gov/ compound /Lidocaine#section = Solubility
`
`ILI
`
`86
`
`11/19/2020
`117-GAI rani.
`
`m/z Top Peak
`
`m/z 2nd Highest
`
`m/z 3rd Highest
`
`Thumbnail
`
`   
`()*+,ÿ./+01
`456ÿ()7ÿ./+0
`456ÿ:;<ÿ=>?@/1*
`456ÿBC<ÿ=>?@/1*
`(@F4G;+>,
`HIJKÿMNOOÿJPQRSTUVQSTWÿXNSNÿYQZSQT
`[\]\]MJ^MJ
`J_U`aZbÿ]ÿUcÿdeaQ`ÿMUTQ
`MJ^MJÿJPQRSTiVÿ[[jkllÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[jkl[ÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[jkldÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[][tjÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[][t]ÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[][tlÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[][t[ÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`fghfg
`MJ^MJÿJPQRSTiVÿ[[][tdÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[][trÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[][tuÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[][tvÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[][ttÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`MJ^MJÿJPQRSTiVÿ[[]dkkÿ^ÿmanURNaZQÿopMXqkkj[[]rs
`piVNZÿMQSNwUxUVQÿXNSNwNOQÿopMXqs
`yzg(ÿyF4G/C
`2EEED3{
`z;1*CF4/;*ÿ(|7/
`}~€‚ÿ„…†‡
`ˆ),,>1>);ÿ‰;/C?|
`E
`g7/Š*CF4ÿ(|7/
`‹Œ3
`.C/ŠFC1)Cÿ(|7/
`‹ŽŽ
`.C/ŠFC1)Cÿ456
`3DA‘28EA
`()*+,ÿ./+01
`3
`456ÿ()7ÿ./+0
`89
`456ÿ:;<ÿ=>?@/1*
`3DA
`456ÿBC<ÿ=>?@/1*
`E
`(@F4G;+>,
`  
    !   
`
"
 #$%
`
`

`

`11/19/2020
`
`NIST Mass Spectrometry Data Center
`
`4.2.3 LC -MS
`
`Showing 2 of 5 View More
`
`MoNA ID
`
`MS Category
`
`MS Type
`
`MS Level
`
`Precursor Type
`
`precursor m/z
`
`Instrument
`
`Instrument Type
`
`Ionization Mode
`
`Collision Energy
`
`FiehnHILIC000481
`
`Experimental
`
`LC -MS
`
`MS2
`
`[M +H]+
`
`235.1801
`
`Thermo Q Exactive HF
`
`LC- ESI -QFT
`
`positive
`
`HCD (NCE 20- 30 -40 %)
`
`Splash
`
`splashl0 -000i- 9030000000- 18fa4f9fdd5d0e32ca2e
`
`Thumbnail
`
`050
`
`Submitter
`
`Megan Showalter, University of California, Davis
`
`MassBank of North America (MONA)
`
`MoNA ID
`
`MS Category
`
`MS Type
`
`MS Level
`
`Precursor Type
`
`precursor m/z
`
`Instrument
`
`Instrument Type
`
`Ionization Mode
`
`Collision Energy
`
`Splash
`
`Thumbnail
`
`FiehnHILIC002053
`
`Experimental
`
`LC -MS
`
`MS2
`
`[M +H]+
`
`235.1828
`
`SCIEX TripleTOF 6600
`
`LC- ESI -QTOF
`
`positive
`
`35 eV
`
`splashl0 -000i- 9000000000- 5014490f0be4e78dd24f
`
`   
`'()*ÿ,-..ÿ)/0123450236ÿ7-2-ÿ809203
`:;<;=>8?,)
`)@4AB9Cÿ<ÿ4DÿEFB0Aÿ,430
`GHIJÿLM
`NB0@9O(>(8PPP:QR
`GSÿTUVWXHYZ
`[\]^_`a^bcde
`GSÿfZgW
`hijkl
`GSÿmWnWo
`klp
`qYWrsYtHYÿfZgW
`ukvwxv
`gYWrsYtHYÿyz{
`p|}~€
`L‚tVYsyW‚V
`ƒ„^_a…ÿ‡ÿ[\dˆc`‰^ÿwŠ
`L‚tVYsyW‚VÿfZgW
`hij[l‹j‡Šƒ
`LH‚Œ{UVŒH‚ÿGHW
`]…Ž`c`‰^
`THooŒtŒH‚ÿ‚WYXZ
`wiÿ‘’i[ÿpj|j“”•
`SgoUt–
`./—-.@RP?PPPB?˜P=PPPPPPP?RQD-:D˜D™™E™P0=<1-<0
`f–syš‚UŒo
`k^›dbÿl„…œdec^_ÿžb`‰^_Ž`cŸÿ… ÿide` …_b`dÿd‰`Ž
`SsšyŒVVWY
`,-..¡-9¢ÿ4Dÿ'432@ÿ£503B1-ÿ¤,4'£¥
`GHIJÿLM
`NB0@9O(>(8PP<PE=
`GSÿTUVWXHYZ
`[\]^_`a^bcde
`GSÿfZgW
`hijkl
`GSÿmWnWo
`klp
`qYWrsYtHYÿfZgW
`ukvwxv
`gYWrsYtHYÿyz{
`p|}~€p€
`L‚tVYsyW‚V
`li‹[¦ÿƒ_`]e^ƒ§Šÿ¨¨
`L‚tVYsyW‚VÿfZgW
`hij[l‹j‡ƒ§Š
`LH‚Œ{UVŒH‚ÿGHW
`]…Ž`c`‰^
`THooŒtŒH‚ÿ‚WYXZ
`|}ÿ^©
`SgoUt–
`./—-.@RP?PPPB?˜PPPPPPPPP?EPR::˜PDPª0:0«Q™™<:D
`f–syš‚UŒo
`  
    !   
`
"
 #$%
`
`https : / /pubchem.ncbi.nlm.nih.gov/ compound /Lidocaine#section = Solubility
`
`Lidocaine C14H22N20 - PubChem
`
`
`
ÿÿ  ÿÿ

`
`Lignocaine
`nncrnnc fr..mnr.hr-
`
`MONA FiehnHILIC000481
`
`los
`
`200
`
`O U
`
`14/74
`
` &
`
`

`

`11/19/2020
`
`Lidocaine C14H22N20 - PubChem
`
`MANA FiehnHILIC002053
`
`Submitter
`
`Megan Showalter, University of California,'Ctavis
`
`MassBank of North America (MoNA)
`
`4.2.4 EI-MS
`
`LEI-MS
`
`El -MS Spectrum 197 - Lidocaine (HMDB0014426)
`
`Human Metabolome Database (HMDB)
`
`4.2.5 Other MS
`
`Other MS
`
`MASS: 35696 (NITS /EPA/MSDC Mass Spectral database, 1990 version)
`
`Hazardous Substances Data Bank (HSDB)
`
`4.3 IR Spectra
`
`4.3.1 FTIR Spectra
`
`Technique
`
`KBr WAFER
`
`Source of Sample
`
`Astra Pharmaceutical Products, Inc., Worcester, Massachusetts
`
`Copyright
`
`Copyright m 1980, 1981 -2018 Bio -Rad Laboratories, Inc. All Rights Reserved.
`
`Thumbnail
`
`Preview: T lest Peak (20x zoo
`
`I
`
`1450
`
`   
`
`
ÿÿ  ÿÿ

`GŠ¥“ˆXXZ[
`]qŸn~ÿ_–}¬nusqtxÿ­~|{qto|sžÿ}®ÿnu|®}t~|nxÿ¨n{|o
`()**+),-ÿ/0ÿ1/234ÿ567289)ÿ:(/15;
`<=>=<?@A(B
`CDEFG
`?@A(BÿBH7932I6ÿJKLÿAÿM8N/9)8,7ÿ:O(P+QQJ<<>R;
`OI6),ÿ(73)S/T/67ÿP)3)S)*7ÿ:O(P+;
`<=>=UV3472ÿ(B
`WXYZ[ÿFG
`]^__`ÿbcdedÿfghi_jkl^j(BPmÿ]nooÿ_pqrstnuÿvnsnwnoqxÿyeezÿ{qto|}~
`<=@‚ÿBH7932)
`O)€)2N/I*ÿBIS*3),97*ÿP)3)ÿ+),-ÿ:OBP+;
`<==Jƒ„@‚ÿBH7932)
`…Z†Y‡ˆ‰ŠZ
`‹Œtÿ^Žk
`GŠ[†Zÿ‘ÿG’“”•Z
`^ostnÿl–nt—nrq˜s|rnuÿlt}v˜rsoxÿh~r™xÿ}trqosqtxÿ]noonr–˜oqsso
`š”›[ˆœYX
`}pžt|Ÿ–sÿ ÿye¡zxÿye¡y¢£zy¡ÿŒ|}¢nvÿ¤nw}tns}t|qoxÿh~r™ÿ^uuÿ|Ÿ–soÿqoqt{qv™
`…YŠ“¥‡’ˆ•
`BH7932)+)*7
`<==>5„‚A@‚ÿBH7932)
`Œ|}¢nvÿŽi_
`D‡¦X[Š“Z‡Xÿ§’“Z
`…Z†Y‡ˆ‰ŠZ
`^i¢gqnsÿf¨˜tn_n—puhÿhh
`GŠ[†Zÿ‘ÿG”Z†X[Š“
`Ž}tq~o|rÿ_pqrstnuÿqoqntr–
`GŠ[†Zÿ‘ÿG’“”•Z
`^uusqr–ÿ^oo}r|nsqoxÿh~r™xÿ©tnrqÿ¨n{|o}~ÿ¨|or}{qtžÿ_r|q~rqo
`š’X’•œÿ§Š“¥Z[
`zy¡ª£
`«Xÿ§Š“¥Z[
`yb£
`š”›[ˆœYX
`}pžt|Ÿ–sÿ ÿ£zze¢£zy¡ÿŒ|}¢nvÿ¤nw}tns}t|qoxÿh~r™ÿ^uuÿ|Ÿ–soÿqoqt{qv™
`…YŠ“¥‡’ˆ•
`  
    !   
`
"
 #$%
`
`1550
`
`1500
`CM-1
`Copr. O 1980, 1981 -2018 Bio -Rad. All Rights Reserved.
`
`Spectra Base
`
`4.3.2 ATR -IR Spectra
`
`Instrument Name
`
`Bio -Rad FTS
`
`Technique
`
`ATR -Neat (DuraSampllR II)
`
`Source of Spectrum
`
`Forensic Spectral Research
`
`Source of Sample
`
`Catalog Number
`
`Lot Number
`
`Copyright
`
`Thumbnail
`
`Alltech Associates, Inc., Grace Davison Discovery Sciences
`
`01842
`
`132
`
`Copyright m 2009 -2018 Bio -Rad Laboratories, Inc. All Rights Reserved.
`
`https : / /pubchem.ncbi.nlm.nih.gov/ compound /Lidocaine#section = Solubility
`
`O G
`
`O U
`
`O U
`O El
`
`O r
`
`15/74
`
`& '
`
`

`

`
`
ÿÿ  ÿÿ

`?@ABCDCE
`?NOPEQRSÿUVPSWOCXÿBPQPCOSY
`\XXWPSYÿ\QQNSRCWPQ]ÿ^ES_]ÿ`OCSPÿaCbRQNEÿaRQSNbPOcÿUSRPESPQ
`hijkl
`inl
`pNVcORqYWÿrÿlhilAlhijÿsRNABCtÿuCvNOCWNORPQ]ÿ^ES_ÿ\XXÿBRqYWQÿBPQPObPt_
`
`   
`1213.4.5ÿ()*+,-.
`()*+,-./.0*
`789:;<=>8
`FG>H98ÿGJÿFK89LH>M
`FG>H98ÿGJÿFZMK[8
`dZLZ[Geÿf>Mg8H
`mGLÿf>Mg8H
`dGKoH<e:L
`7:>Mg;Z<[
`12wx,y*-ÿ()*+,-.ª.«.-¬­®0ÿ(®¯0,.5+*0ÿ°.,.ÿ/.5±ÿ²ª(°/³
`()*+,-./.0*
`^EWPEQPÿDCQQÿQVPSWOCXÿVPCzQ{ÿ|jÿD}~]ÿlÿD}~]ÿj€ÿD}~]ÿlnkÿD}~
`‚ƒ„…„†‡ÿ‰Š‡ÿ‹ŠÿŒŽ†„†ÿÿ‘Šÿ’„“„†ŠÿŒ””ÿ•–„—˜†ƒÿÿ™šÿ›˜ÿœ‚ÿ›†Ž…”‡ÿœ”œ”ÿÿ˜ž„†ÿŒ„˜“œƒ˜„”Šÿ†˜”ÿŸÿÿŸŸŠÿŒ””ÿ•–„—˜†ÿŸ„ „”Šÿ’„ž„¡‡ÿ¢„„†ƒÿ£„–Ž“ƒ—ÿœ‚ÿ™„†¡¤Šÿ¥¦§¨Š‡ÿ–Šÿ©§¥
`
`
`  
    !   
`
"
 #$%
`
`& '
`
`

`

`5067089-ÿ5i
`UG[DIV[BPÿ DK¡¢JQÿ¡£CG[
`vwwxy
`v‹Œx‹y
`v~‹xy
`v‹‹x~‘
`vy~x‹Œ
`
`'()*+,)-ÿ()/01-2
`   
`
`
ÿÿ  ÿÿ

`'34()*+,)-ÿ5067089-2ÿ:;,<ÿ=990,+,;09
``_^'`ÿ;,)62f;):ÿg01)ÿ(0:2ÿhÿi),+;*2
`—˜™šÿjœ
`AJPVIJVPD
`FGCXGVHYÿFžŸ
`ZBCD
`UG[DIV[BPÿ]GPCV[B
`@TbT
`jklmnopomqr
`5stu
`4¤@¤@
``N@T
`zv{|v}~{m€r‚ƒ„oqm„mq…†{v{…‡…r‚ƒ„ˆ{‰mr‚ƒ„oŠoqmk€
`5stu
`4T@`@¥
`5stu
`v{z|v}~{m€r‚ƒ„l‚rqƒ„†o€mq…ˆ{}}{Žmr‚ƒ„{v{…‡…r‚oqo€mqmk€
``N@'
`4^@b@¥
``N'c
`…€kmqr
`5s5*tu
`N4^`@
`Tc^@
`’rlmnopomqr
`5stu
`4'@@@
`“”•xxx–•“ZDSJ
`'3@()*+,)-ÿ5067089-2
`>8?5<)6
`ABCDÿFGHHDIJKLKJM
`Nÿ()/01-2
`ABCDÿOBPDHJQÿFGHHDIJKLKJM
`'@ÿ()/01-2
`ABCDÿOBPDHJQÿRSBIJ
`T@ÿ()/01-2
`UKSJVPDWQÿFGCXGHDHJWQÿBHY
`@^@ÿ()/01-2
`ZDVJPB[K\DYÿ]GPCW
`AKCK[BPÿFGCXGVHYW
`4_`TNÿ()/01-2
`AKCK[BPÿFGHaGPCDPW
`@_Tbcÿ()/01-2
`'3`d8?2,+9/)2
`>8?5<)6
`'3`34()*+,)-ÿd8?2,+9/)2
`e[[
`4_c44ÿ()/01-2
`ABCD
`@bcÿ()/01-2
`UKSJVPD
`bT4ÿ()/01-2
`>8?5<)6
`  
    !   
`
"
 #$%
`
`& &
`
`

`

`
`
ÿÿ  ÿÿ

`
`   
`()*)+,-./01234/ÿ.6ÿ710489:6
`fÿ710489:B4/?qr12N4NÿsB4t
`7<4=B31Aÿs42N9:/ÿlfam
`7-:10B92ÿ?uu9:0/ÿl+Km
`v9w4:2=4201Aÿp:812B@10B92/ÿl>_m
`x9-:21Aÿ;-.AB/<4:/ÿl(m
`noiÿo2B0B10Bw4/ÿl*Lm
`M4/41:3<ÿb2Nÿj4w4A9r=420ÿla>m
`,-./3:Br0B92ÿ,4:wB34/ÿl>m
`c48136ÿj4r9/B09:/ÿl*hm
`()>?20:4@ÿ7:9//AB2C/
`;-.7<4=
`DEFGHI
`+J(KLÿM439:N/
`DOPQHRSÿUQOEVQEOHW
`+ÿM439:N/
`XYZPSP[\
`>ÿM439:N/
`]G^G
`_>ÿM439:N/
``HSH
`aKÿM439:N/
`()(b//93B104Nÿ7<4=B31A/
`;-.7<4=
`cBN931B24ÿ<6N:93<A9:BN4dÿf*gfhga
`()Ln7koÿcB2Cp-0
`i1@1:N9-/ÿ,-./01234/ÿj101ÿk12Cÿli,jkm
`n7ko
`  
    !   
`
"
 #$%
`
`& '
`
`

`

`'()*+,-./ÿ1*23456
`   
`
`
ÿÿ  ÿÿ

`7)48,29ÿ:ÿ7;<6=.2-*ÿ>*5ÿ1*23451,*8ÿ?//
`@Aÿ7-,*2=,B,-ÿCD;).2Eÿ(45>
`FGHIJKLÿNOPQÿ@RS:STUVV
`FG

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket